rheumatic heart disease
Information
- Disease name
- rheumatic heart disease
- Disease ID
- DOID:0050827
- Description
- "A heart valve disease that is characterized by repeated inflammation with fibrinous repair caused by an autoimmune reaction to Group A beta-hemolytic streptococci (GAS) that results in valvular damage. The cardinal anatomic changes of the valve include leaflet thickening, commissural fusion, and shortening and thickening of the tendinous cords." [url:http\://en.wikipedia.org/wiki/Rheumatic_heart_disease]
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
| Genes | Mutation | Description | Source | Links |
|---|
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT04575857 | Active, not recruiting | Role of Statins In Slowing Rheumatic Heart Disease (RHD) Progression | February 8, 2022 | February 2040 | |
| NCT05250154 | Active, not recruiting | Rheumatic Heart Disease Research and Screening in Nepal: A Feasibility Study | August 27, 2018 | May 1, 2040 | |
| NCT05211024 | Active, not recruiting | A Long-term Follow up Study for Patients Who Participated in the GOAL Trial (GOAL-Post) | January 28, 2022 | June 2024 | |
| NCT01178710 | Completed | N/A | Effect of Simvastatin on Cardiac Function | September 2010 | July 2012 |
| NCT01550068 | Completed | N/A | Rheumatic Heart Disease School Project | December 2012 | April 30, 2019 |
| NCT01794884 | Completed | Phase 2 | Validity Study of Glutamine to Improve Cardiac Function in Cardiac Surgery | January 2013 | March 2014 |
| NCT05668611 | Completed | N/A | Train the Trainer Curriculum to Scale up AI Supported Echo for RHD Screening in a Public Health System | January 3, 2023 | December 20, 2023 |
| NCT02124109 | Completed | The Genetic Basis of Acquired Heart Disease in Africa | April 3, 2014 | February 6, 2020 | |
| NCT02188862 | Completed | Genetic Susceptibility to Rheumatic Heart Disease in the Pacific Region | September 2012 | December 2013 | |
| NCT02353663 | Completed | Rheumatic Heart Disease in Peru: Prevalence and Cardiovascular Outcomes Among Schoolchildren | April 2014 | July 2015 | |
| NCT02474108 | Completed | N/A | Surgical Prevention of Atrial Fibrillation in Patients With Rheumatic Mitral Valve Lesion and Left Atrium Enlargement | March 2, 2015 | October 20, 2016 |
| NCT02661763 | Completed | Rheumatic Heart Disease Study in Lusaka | September 2015 | December 2015 | |
| NCT05502042 | Completed | N/A | Case Management and Peer Support Groups for Prophylaxis Adherence in Rheumatic Heart Disease | August 15, 2022 | September 1, 2023 |
| NCT02832544 | Completed | Phase 3 | INVestIgation of rheumatiC AF Treatment Using Vitamin K Antagonists, Rivaroxaban or Aspirin Studies, Non-Inferiority | August 22, 2016 | August 18, 2022 |
| NCT02881398 | Completed | Phase 2/Phase 3 | Mobile Health in Structural Heart Disease | August 2014 | January 2016 |
| NCT05276999 | Completed | N/A | Rheumatic Heart Disease Community Streptococcal Treatment Program "RESET" | January 31, 2022 | March 30, 2024 |
| NCT00482573 | Completed | Phase 1 | Dental Anesthesia in Pregnant Women With Rheumatic Heart Disease | April 2004 | January 2006 |
| NCT00264524 | Completed | N/A | DNA Typing of HLA-DR/DQ Alleles in Taiwan Chinese With Rheumatic Heart Disease | January 2004 | July 2005 |
| NCT06150274 | Not yet recruiting | N/A | Comparison of Wire Assisted Percutaneous Balloon Mitral Valvulotomy With Standard Inoue Balloon Valvulotomy | May 2024 | December 31, 2026 |
| NCT05618223 | Not yet recruiting | Phase 3 | Dapagliflozin Effect on Rheumatic Mitral Stenosis | December 1, 2022 | June 30, 2023 |
| NCT06002243 | Not yet recruiting | N/A | Non-Expert Acquisition & Remote Expert Review of Screening Echocardiography Images From Child Health & AnteNatal Clinics | April 2024 | December 2025 |
| NCT06097585 | Not yet recruiting | Gliflozins on HF in Regurgitant Rheumatic Heart | December 1, 2023 | April 1, 2025 | |
| NCT05693545 | Recruiting | Phase 2 | GOALIE: Intramuscular vs. Enteral Penicillin Prophylaxis to Prevent Progression of Latent RHD Trial | September 1, 2023 | September 30, 2027 |
| NCT04936815 | Recruiting | N/A | Echocardiographic Screening of Pregnant Women During Antenatal Care | December 1, 2021 | December 31, 2024 |
| NCT04556188 | Recruiting | The Clinical Influence of Developing a Sustainable Cardiac Surgery Service to Reduce the Burden of Rheumatic Heart Disease in Sub-Saharan Africa | March 1, 2016 | December 31, 2024 | |
| NCT03991910 | Recruiting | Phase 3 | The Effect of Ramipril in Suppressing ST2 Expression in Rheumatic Mitral Stenosis Patients | June 27, 2019 | August 8, 2024 |
| NCT05487469 | Recruiting | N/A | Thymosin α1 Use in Rheumatic Heart Disease Patients Undergoing Cardiac Surgery on Cardiopulmonary Bypass | July 1, 2022 | December 31, 2023 |
| NCT05991219 | Recruiting | Screening and Secondary Prevention Rheumatic Heart Disease Study | September 26, 2022 | December 31, 2028 | |
| NCT05504928 | Recruiting | N/A | Effectiveness of a School-centered Prevention Program on Prevalence of Latent Rheumatic Heart Disease | June 1, 2022 | December 1, 2026 |
| NCT05783375 | Recruiting | N/A | Accelerating Delivery of rheUmatic Heart Disease Preventive iNterventions in Northern Uganda | May 1, 2024 | January 31, 2028 |
| NCT02118818 | Recruiting | RhEumatiC Heart diseAse Genetics | February 2014 | July 2024 | |
| NCT03926156 | Terminated | Phase 3 | RIvoraxaban in Mitral Stenosis | May 22, 2019 | August 14, 2021 |
| NCT00779662 | Unknown status | The Prevalence of Rheumatic Heart Disease in School Children in Fiji | February 2008 | December 2008 | |
| NCT03156972 | Unknown status | N/A | Speckle Tracking for Timing of Surgical Operation in Severe Mitral Regurge | April 1, 2017 | August 1, 2018 |
| NCT03346525 | Unknown status | Phase 2 | Determining the Impact of Penicillin in Latent RHD: The GOAL Trial | June 26, 2018 | November 30, 2020 |
| NCT03549052 | Unknown status | Right Ventricular Echo Assessment in Mitral Valve Replacement | June 1, 2018 | January 2020 | |
| NCT02832531 | Withdrawn | Phase 3 | INVestIgation of rheumatiC AF Treatment Using Vitamin K Antagonists, Rivaroxaban or Aspirin Studies, Superiority | January 2022 | August 2022 |
- Disase is a (Disease Ontology)
- DOID:4079
- Cross Reference ID (Disease Ontology)
- MESH:D012214
- Exact Synonym (Disease Ontology)
- rheumatic carditis
- MedGen concept unique identifier (MedGen Concept name)
- C0035439
- MedGen unique identifier (MedGen Concept name)
- 20565
- MeSH unique ID (MeSH (Medical Subject Headings))
- D012214