Lambert-Eaton myasthenic syndrome
Information
- Disease name
- Lambert-Eaton myasthenic syndrome
- Disease ID
- DOID:0050214
- Description
- "A neuromuscular junction disease that is characterized by an abnormality of acetylcholine (ACh) release at the neuromuscular junction which results from an autoimmune attack against voltage-gated calcium channels (VGCC) on the presynaptic motor nerve terminal." [url:http\://en.wikipedia.org/wiki/Lambert%E2%80%93Eaton_myasthenic_syndrome]
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
| Genes | Mutation | Description | Source | Links |
|---|
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT00872950 | Approved for marketing | 3,4-Diaminopyridine Use in Lambert-Eaton Myasthenic Syndrome(LEMS) and Congenital Myasthenic Syndromes (CMS) | |||
| NCT00004832 | Completed | N/A | Randomized Study of 3,4-Diaminopyridine for Lambert-Eaton Myasthenic Syndrome | August 1994 | June 1998 |
| NCT01511978 | Completed | Phase 2 | Effectiveness of 3,4-Diaminopyridine in Lambert-Eaton Myasthenic Syndrome | January 2012 | July 2015 |
| NCT02970162 | Completed | Phase 3 | Phase 3 Study to Evaluate Efficacy of Amifampridine Phosphate in Lambert-Eaton Myasthenic Syndrome (LEMS) | November 2016 | October 2017 |
| NCT05408702 | Completed | Exercise in Autoimmune Myasthenia Gravis and Myasthenic Syndromes | November 12, 2021 | May 15, 2022 | |
| NCT02189720 | No longer available | Expanded Access Study Amifampridine Phosphate in Lambert-Eaton Myasthenic Syndrome (LEMS),Congenital Myasthenic Syndrome | |||
| NCT00994916 | No longer available | Treatment of Lambert-Eaton Syndrome With 3,4 Diaminopyridine | |||
| NCT01373333 | No longer available | Use Of 3,4-Diaminopyridine (3,4-DAP) In The Treatment Of Lambert Eaton Myasthenic Syndrome | September 1997 | ||
| NCT06441825 | Recruiting | Patient Observation With Environmental and Wearable Sensors in Myasthenia Gravis | May 2, 2024 | October 31, 2025 |
- Disase is a (Disease Ontology)
- DOID:439
- Cross Reference ID (Disease Ontology)
- ICD10CM:G70.80
- Cross Reference ID (Disease Ontology)
- ICD9CM:358.3
- Cross Reference ID (Disease Ontology)
- MESH:D015624
- Cross Reference ID (Disease Ontology)
- NCI:C3155
- Cross Reference ID (Disease Ontology)
- SNOMEDCT_US_2023_03_01:230688006
- Cross Reference ID (Disease Ontology)
- UMLS_CUI:C0022972
- Exact Synonym (Disease Ontology)
- Eaton-Lambert syndrome
- Exact Synonym (Disease Ontology)
- Lambert-Eaton syndrome
- Exact Synonym (Disease Ontology)
- LEMS
- OrphaNumber from OrphaNet (Orphanet)
- 43393
- MeSH unique ID (MeSH (Medical Subject Headings))
- D015624