chr7:22765503:> Detail (hg19)

Information

Genome

Assembly Position
hg19 chr7:22,765,503-22,771,621
hg38 chr7:22,725,884-22,732,002 

HGVS

Type Transcript Protein
Summary

MGeND

Clinical significance
Variant entry
GWAS entry
Disease area statistics Show details

Frequency

[No Data.]

Prediction

[No Data.]

ClinVar

Clinical Significance
Review star [No Data.]
Show details
Links
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
[No Data.]
CIViC
[No Data.]
DisGeNET
Score Disease name Description Source Pubmed Links
0.143 squamous cell carcinoma NA BeFree,CTD_human,GAD,LHGDN Detail
0.001 Carcinoma, Transitional Cell Furthermore, our results suggested that urinary IL-8, IL-6 and CK-18 may benefit... BeFree 25640370 Detail
<0.001 Cardiomyopathy, Dilated NA BeFree Detail
0.094 Cardiovascular Diseases Whereas, the IL-6 -572G/C polymorphism showed that the variant genotype (GC+CC) ... BeFree,GAD,LHGDN 25274950 Detail
0.094 Cardiovascular Diseases The parallel relationship with history of CVD and incident CV events of the -174... BeFree,GAD,LHGDN 25492254 Detail
0.011 Carotid Artery Diseases NA BeFree,GAD,LHGDN Detail
0.003 carotid stenosis NA BeFree,LHGDN Detail
0.011 celiac disease As in other matrix expansion disorders, IL-6 is upregulated and represents a log... BeFree,GAD,LHGDN 25198673 Detail
0.120 Neoplastic Cell Transformation NA CTD_human Detail
<0.001 CNS disorder NA BeFree Detail
0.008 intracranial aneurysm NA BeFree,GAD Detail
0.125 Intracranial Arteriovenous Malformation NA CTD_human,GAD Detail
0.002 cerebral infarction NA BeFree Detail
0.132 brain ischemia NA BeFree,CTD_human,GAD Detail
0.003 Transient ischemic attack NA BeFree,GAD Detail
0.016 cerebral palsy NA BeFree,GAD,LHGDN Detail
0.004 Malignant tumor of cervix Stratification analysis and case-control study of relationships between interleu... BeFree 25227842 Detail
0.005 Uterine Cervical Neoplasm NA BeFree,GAD Detail
<0.001 Chagas Cardiomyopathy NA BeFree Detail
<0.001 Charcot-Marie-Tooth disease NA BeFree Detail
<0.001 Chediak-Higashi syndrome At baseline, we found CD14, IL1R1 and TLR-1 were down-regulated significantly (≥... BeFree 25528552 Detail
0.005 Chlamydia Infections NA BeFree,GAD Detail
<0.001 Primary biliary cirrhosis NA BeFree Detail
<0.001 Cholangitis, Sclerosing NA BeFree Detail
<0.001 cholelithiasis NA BeFree Detail
<0.001 cholera NA BeFree Detail
0.120 cholestasis NA CTD_human Detail
<0.001 chondrosarcoma NA BeFree Detail
0.010 chorioamnionitis NA GAD,LHGDN Detail
<0.001 choriocarcinoma NA BeFree Detail
<0.001 Congenital chromosomal disease NA BeFree Detail
0.002 Bronchitis, Chronic NA GAD Detail
0.130 colitis In mice, IL-19 up-regulates TNFα and IL-6 expression and its deficiency increase... BeFree,CTD_human,LHGDN 24718601 Detail
0.130 colitis Using two murine models of bowel injury - wound by biopsy and bacterial triggere... BeFree,CTD_human,LHGDN 25478789 Detail
0.130 colitis Butein ameliorated colitis in IL-10(-/-) mice by regulating IL-6/STAT3 and MMP-9... BeFree,CTD_human,LHGDN 25593461 Detail
0.130 colitis 15-Lipoxygenase-1 suppression of colitis-associated colon cancer through inhibit... BeFree,CTD_human,LHGDN 25713055 Detail
<0.001 Colonic Diseases NA BeFree Detail
0.005 Colonic Neoplasms NA BeFree,GAD Detail
0.012 colorectal carcinoma The Th17 cell differentiation simulators IL-1β and IL-6 were also shown in an in... BeFree 24859972 Detail
0.012 colorectal carcinoma Bradykinin stimulates IL-6 production and cell invasion in colorectal cancer cel... BeFree 25109623 Detail
0.012 colorectal carcinoma Th17-type cytokines, IL-6 and TNF-α synergistically activate STAT3 and NF-kB to ... BeFree 25174402 Detail
0.012 colorectal carcinoma Upregulation of TLRs and IL-6 as a marker in human colorectal cancer. BeFree 25547486 Detail
0.012 colorectal carcinoma Interleukin-6 (IL-6) promotes cellular proliferation and drug resistance in colo... BeFree 25625841 Detail
0.012 colorectal carcinoma Identification of 15-LOX-1 suppression of PPAR-δ to inhibit IL-6/STAT3 signaling... BeFree 25713055 Detail
0.012 colorectal carcinoma Differential role of MACC1 expression and its regulation of the HGF/c‑Met pathwa... BeFree 25738887 Detail
0.012 colorectal carcinoma In this study, we demonstrate that fos-related antigen-1 (Fra-1) plays a critica... BeFree 25750173 Detail
0.022 Colorectal Neoplasms EMAST-positive colorectal tumors had significantly higher levels of IL6 than EMA... BeFree,GAD,LHGDN 25461668 Detail
<0.001 Comatose NA BeFree Detail
0.008 common cold NA BeFree,GAD Detail
0.003 common variable immunodeficiency NA BeFree,GAD Detail
<0.001 Condylomata Acuminata Relationship between the interleukin-6-174 gene and mannose-binding lectin codon... BeFree 24118442 Detail
0.002 Connective Tissue Diseases NA GAD Detail
0.009 Febrile Convulsions Association of IL6 single nucleotide polymorphisms with febrile seizures. BeFree,GAD,LHGDN 24834995 Detail
0.002 Corneal Diseases NA GAD Detail
<0.001 corneal ulcer NA BeFree Detail
0.014 Coronary Arteriosclerosis IL-6 gene promoter polymorphisms and risk of coronary artery disease in a Chines... BeFree 25299085 Detail
0.014 Coronary Arteriosclerosis Role of IL-6 polymorphism on the development of cardiovascular events and corona... BeFree 25867411 Detail
0.065 Coronary heart disease IL-6 gene promoter polymorphisms and risk of coronary artery disease in a Chines... BeFree,GAD,LHGDN 25299085 Detail
0.065 Coronary heart disease IL6R haplotype associations with C-reactive protein (CRP), fibrinogen, IL6, solu... BeFree,GAD,LHGDN 25781951 Detail
0.065 Coronary heart disease Role of IL-6 polymorphism on the development of cardiovascular events and corona... BeFree,GAD,LHGDN 25867411 Detail
0.002 coronary thrombosis NA GAD Detail
0.003 coronary artery vasospasm NA BeFree,GAD Detail
0.003 craniopharyngioma NA BeFree,LHGDN Detail
<0.001 craniosynostosis The levels of IL-6, soluble IL-6 receptor (sIL-6R), soluble gp130 (sgp130), and ... BeFree 26266960 Detail
0.140 Crohn Disease NA BeFree,CTD_human,GAD,LHGDN Detail
<0.001 Infection by Cryptococcus neoformans First, wild-type or IL-6(-/-) mice were injected with Cryptococcus neoformans (C... BeFree 25740137 Detail
0.003 Cushing syndrome NA LHGDN Detail
0.006 cystic fibrosis NA BeFree,GAD Detail
<0.001 Cyst NA BeFree Detail
0.001 Cytomegalovirus Infections NA BeFree Detail
0.001 Delirium NA BeFree Detail
0.003 Multi-infarct dementia NA BeFree,GAD Detail
0.002 Presenile dementia NA BeFree Detail
<0.001 Dementia, Vascular NA BeFree Detail
<0.001 Dengue Fever NA BeFree Detail
<0.001 dental caries NA BeFree Detail
0.007 Dental Plaque NA GAD Detail
0.006 Mental Depression However, IL6 genotype did not moderate the effects of non-interpersonal stress e... BeFree,GAD 25596176 Detail
0.006 Mental Depression STAT3 controls IL6-dependent regulation of serotonin transporter function and de... BeFree,GAD 25760924 Detail
0.204 depressive disorder However, IL6 genotype did not moderate the effects of non-interpersonal stress e... BeFree,CTD_human,RGD 25596176 Detail
0.204 depressive disorder STAT3 controls IL6-dependent regulation of serotonin transporter function and de... BeFree,CTD_human,RGD 25760924 Detail
0.001 dermatitis TLR2 activation in skin resident cells triggered interleukin-6 (IL-6), which ind... BeFree 25456159 Detail
0.129 Dermatitis, Atopic NA BeFree,CTD_human,GAD Detail
<0.001 dermatomyositis NA BeFree Detail
<0.001 scleroderma NA BeFree Detail
0.200 Diabetes Mellitus, Experimental NA CTD_human,RGD Detail
0.051 Diabetes Mellitus, Insulin-Dependent NA BeFree,GAD,LHGDN Detail
0.002 Diabetic Angiopathies NA GAD Detail
0.085 Diabetic Nephropathy NA BeFree,GAD,RGD Detail
0.005 diabetic retinopathy NA LHGDN Detail
<0.001 diarrhea NA BeFree Detail
0.003 Pathological Dilatation NA LHGDN Detail
<0.001 disseminated intravascular coagulation NA BeFree Detail
0.003 Down syndrome NA BeFree,LHGDN Detail
<0.001 Drug abuse NA BeFree Detail
<0.001 Drug habituation All genes increased in response to initial stress (IL-6: F=3.8; p=0.029; IL-1β: ... BeFree 25683696 Detail
0.006 Dry Eye Syndromes NA BeFree,GAD,LHGDN Detail
0.005 duodenal ulcer NA GAD Detail
<0.001 dysentery NA BeFree Detail
<0.001 Shigella Infections NA BeFree Detail
<0.001 Dyspnea NA BeFree Detail
0.003 eclampsia NA BeFree,GAD Detail
0.009 Eczema Genes in eczema related to epidermal barrier, reduced innate immunity, increased... BeFree,GAD 25009230 Detail
0.122 Edema NA CTD_human,GAD Detail
<0.001 elephantiasis NA BeFree Detail
0.004 encephalitis Association of interleukin-6-572C/G gene polymorphism and serum or cerebrospinal... BeFree,LHGDN 25081498 Detail
<0.001 Japanese encephalitis Cells with JEV infection showed impaired LCFA β-oxidation and increased interleu... BeFree 25816318 Detail
0.003 encephalomyelitis NA BeFree,GAD Detail
0.083 Experimental Autoimmune Encephalomyelitis In this research, an IL6-associated miRNA, miR26a, was identified, and its norma... BeFree,RGD 25362566 Detail
<0.001 Bacterial Endocarditis In this study, 14 single nucleotide variants (SNVs) in genes coding for interleu... BeFree 25299518 Detail
0.003 Endometrial Neoplasms NA BeFree,LHGDN Detail
0.032 endometriosis An increased level of IL-6 suppresses NK cell activity in peritoneal fluid of pa... BeFree,GAD,LHGDN 25035432 Detail
0.120 Entamoebiasis NA CTD_human Detail
<0.001 Eosinophilia By contrast, levels of the inflammatory cytokines IL-17A and IL-6 were significa... BeFree 25363529 Detail
<0.001 epidermodysplasia verruciformis NA BeFree Detail
<0.001 epidermolysis bullosa The present study supports that EB might be considered a systemic inflammatory d... BeFree 26496255 Detail
0.001 epilepsy Genomic analysis of the interleukin-1β-511 and interleukin-6-174 gene polymorphi... BeFree 25366750 Detail
0.002 Equine Infectious Anemia NA GAD Detail
0.002 erythema nodosum NA GAD Detail
0.013 Esophageal Neoplasms In a 4-NQO-induced esophageal tumor animal model, MDSC recruitment was associate... BeFree,GAD 25238263 Detail
0.003 esophagitis NA BeFree,LHGDN Detail
<0.001 peptic esophagitis NA BeFree Detail
<0.001 Failure to Thrive NA BeFree Detail
0.001 Fanconi anemia NA BeFree Detail
0.006 Fatigue Pro-inflammatory and antiviral cytokines (granulocyte macrophage colony stimulat... BeFree,GAD 25062274 Detail
0.006 Fatigue Genetic associations were established between fatigue and the G/G genotype of IL... BeFree,GAD 25458605 Detail
0.006 Fatigue For non-Hispanic whites, the IL1β -511 CC genotype was associated with a high ov... BeFree,GAD 25469832 Detail
0.002 chronic fatigue syndrome NA GAD Detail
0.086 Fatty Liver NA BeFree,GAD,RGD Detail
<0.001 Fatty Liver, Alcoholic NA BeFree Detail
0.005 Fetal Death NA GAD Detail
0.002 Fetal Diseases NA GAD Detail
0.003 Fetal Distress NA LHGDN Detail
0.002 Fetal Growth Retardation NA GAD Detail
0.002 Fetal Membranes, Premature Rupture NA GAD Detail
0.122 Fever NA CTD_human,GAD Detail
<0.001 breast fibrocystic disease NA BeFree Detail
0.003 fibrosarcoma NA BeFree,LHGDN Detail
0.008 Fibrosis NA LHGDN Detail
<0.001 Osteitis Fibrosa Disseminata NA BeFree Detail
<0.001 pathologic fistula NA BeFree Detail
0.002 Pathological fracture NA GAD Detail
<0.001 fragile X syndrome Children with FXS displayed similar innate immune response following challenge w... BeFree 24942544 Detail
<0.001 Gangrene NA BeFree Detail
0.008 gastritis NA BeFree,GAD Detail
0.002 Gastritis, Atrophic NA GAD Detail
0.002 gastroenteritis NA GAD Detail
0.002 Gastrointestinal Neoplasms NA GAD Detail
0.003 Gaucher disease NA BeFree,GAD Detail
<0.001 Female Genital Diseases NA BeFree Detail
<0.001 Giant Cell Tumors NA BeFree Detail
0.123 Angiolymphoid hyperplasia NA BeFree,CTD_human,LHGDN Detail
<0.001 giardiasis NA BeFree Detail
0.004 Gingival Diseases NA BeFree Detail
0.002 Gingival Hemorrhage NA GAD Detail
0.005 Gingival Hyperplasia NA GAD Detail
0.002 gingival recession NA GAD Detail
0.006 gingivitis NA BeFree,GAD Detail
0.008 glioblastoma The p38-MK2-HuR pathway potentiates EGFRvIII-IL-1β-driven IL-6 secretion in glio... BeFree 25088200 Detail
0.008 glioblastoma C/EBPβ promotes angiogenesis through secretion of IL-6, which is inhibited by ge... BeFree 25382637 Detail
0.008 glioblastoma The study focused on the role of Oncostatin-M (OSM), an IL-6 family cytokine in ... BeFree 25748242 Detail
0.015 Glioma Six genes independently correlated with either age (IL-6, TNFRSF-11B, IGFBP-3, S... BeFree,GAD,LHGDN 25220188 Detail
0.015 Glioma The effect of hBMVEC on C6 glioma sCp expression at the level of transcript and ... BeFree,GAD,LHGDN 25311416 Detail
0.126 glomerulonephritis NA BeFree,CTD_human,GAD,LHGDN Detail
0.014 IgA glomerulonephritis NA BeFree,GAD,LHGDN Detail
0.003 membranous glomerulonephritis NA BeFree,GAD Detail
0.003 Focal glomerulosclerosis NA BeFree,GAD Detail
0.003 Glossitis, Benign Migratory NA BeFree,GAD Detail
<0.001 gonorrhea NA BeFree Detail
0.002 gout NA GAD Detail
0.030 Graft-vs-Host Disease Risk model incorporating donor IL6 and IFNG genotype and gastrointestinal GVHD c... BeFree,GAD,LHGDN 25774595 Detail
0.007 Graves Disease Increased level of IL-37 in patients with GD are associated with TNF-α, IL-6, IL... BeFree,GAD 25226272 Detail
<0.001 hand, foot and mouth disease Association of interleukin-6-572C/G gene polymorphism and serum or cerebrospinal... BeFree 25081498 Detail
<0.001 Hay fever NA BeFree Detail
<0.001 Head and Neck Neoplasms NA BeFree Detail
0.121 Headache NA BeFree,CTD_human Detail
0.080 Noise-induced hearing loss NA RGD Detail
<0.001 Sensorineural Hearing Loss (disorder) NA BeFree Detail
<0.001 cardiac arrest These data indicate that IL-1β and IL-6 gene SNPs are associated with SCA compli... BeFree 25595815 Detail
0.008 Heart Diseases NA BeFree,GAD,LHGDN Detail
0.080 Cardiomegaly NA RGD Detail
0.205 Heart failure In age, sex- and race- adjusted models, sIL-2Rα was positively associated with c... BeFree,CTD_human,GAD,RGD 26293465 Detail
0.003 congestive heart failure In age, sex- and race- adjusted models, sIL-2Rα was positively associated with c... BeFree 26293465 Detail
<0.001 Heart Neoplasm NA BeFree Detail
0.002 heart valve disease NA GAD Detail
0.120 Heat Stroke NA CTD_human Detail
<0.001 Helminthiasis NA BeFree Detail
0.003 hemochromatosis NA BeFree,GAD Detail
0.120 hemolytic-uremic syndrome NA BeFree,CTD_human Detail
0.003 Hemorrhage NA LHGDN Detail
<0.001 Hemorrhagic Fever, Crimean NA BeFree Detail
0.005 Severe Dengue NA GAD,LHGDN Detail
<0.001 hepatic veno-occlusive disease NA BeFree Detail
0.004 hepatitis NA BeFree,LHGDN Detail
0.001 hepatitis A NA BeFree Detail
0.017 hepatitis B Consistently, mice injected with pAAV-HBV-B and pmIFN-α showed higher expression... BeFree,GAD,LHGDN 24618716 Detail
0.017 hepatitis B IL-6 promoter functional polymorphism -572C/G affects spontaneous clearance of h... BeFree,GAD,LHGDN 25648033 Detail
<0.001 Hepatitis, Chronic NA BeFree Detail
0.014 hepatitis C Combined impact of hepatitis C virus genotype 1 and interleukin-6 and tumor necr... BeFree,GAD 25193024 Detail
0.120 Hepatolenticular Degeneration NA BeFree,CTD_human Detail
0.120 Diaphragmatic hernia NA CTD_human Detail
0.002 Herpes Simplex Infections NA BeFree Detail
0.002 Herpesviridae Infections NA GAD Detail
<0.001 Hip Dislocation, Congenital Association of TGFB1 29C/T and IL6 -572G/C polymorphisms with developmental hip ... BeFree 25603974 Detail
0.028 HIV Infections NA BeFree,GAD Detail
0.021 Hodgkin Disease NA BeFree,GAD,LHGDN Detail
0.005 HTLV-I Infections NA BeFree,GAD Detail
<0.001 Huntington disease NA BeFree Detail
0.200 Hyperalgesia NA CTD_human,RGD Detail
0.121 hypercalcemia NA BeFree,CTD_human Detail
0.006 Hypercholesterolemia NA BeFree,GAD Detail
<0.001 Hypercholesterolemia, Familial NA BeFree Detail
<0.001 Hypergammaglobulinemia NA BeFree Detail
0.009 hyperglycemia The sEng, sFlt-1, and interleukin-6 were up-regulated, whereas the VEGF and PlGF... BeFree,GAD,LHGDN 24793974 Detail
0.004 hyperinsulinism NA BeFree,GAD Detail
0.005 Hyperlipidemia NA GAD Detail
0.120 Hyperoxaluria NA CTD_human Detail
<0.001 hyperparathyroidism NA BeFree Detail
0.120 Hyperparathyroidism, Secondary NA CTD_human Detail
0.125 Hypersensitivity NA CTD_human,GAD Detail
0.031 Hypertensive disease NA BeFree,GAD,LHGDN Detail
<0.001 Hypertension, Portal NA BeFree Detail
0.084 pulmonary hypertension A 10-fold reduction in IL-6 and a 5-fold decrease in hyaluronan, both linked to ... BeFree,GAD,RGD 25318478 Detail
0.080 renal hypertension NA RGD Detail
<0.001 hyperthyroidism NA BeFree Detail
0.003 hypoglycemia NA BeFree,LHGDN Detail
0.120 Hypotension NA CTD_human Detail
0.003 Hypothermia, natural NA LHGDN Detail
<0.001 Type II Mucolipidosis NA BeFree Detail
<0.001 Angioimmunoblastic Lymphadenopathy NA BeFree Detail
<0.001 Immunologic Deficiency Syndromes NA BeFree Detail
<0.001 Immune System Diseases NA BeFree Detail
0.003 inappropriate ADH syndrome NA LHGDN Detail
0.005 Infant, Premature, Diseases NA GAD Detail
0.003 infectious mononucleosis NA BeFree,GAD Detail
0.005 Female infertility NA GAD Detail
0.003 male infertility NA BeFree,GAD Detail
<0.001 Mammary Ductal Carcinoma NA BeFree Detail
0.219 Inflammation NA CTD_human,GAD,LHGDN Detail
0.132 Inflammatory Bowel Diseases In addition, the cytokines IL-1β, IL-6 and IFN-γ may be potential targets for tr... BeFree,CTD_human,GAD 24776844 Detail
0.006 influenza In area under curve analyses, post-LAIV IL-6 responses (P = 0.03) and influenza ... BeFree,GAD 24910991 Detail
0.106 Insulin resistance NA GAD,RGD Detail
<0.001 intermittent claudication Circulating inflammatory biomarkers, including tumor necrosis factor α (TNF-α), ... BeFree 25095746 Detail
<0.001 Intestinal Diseases NA BeFree Detail
<0.001 intestinal perforation Inhibition of this pathway has led to successful treatment of rheumatoid arthrit... BeFree 25478789 Detail
<0.001 intestinal pseudo-obstruction NA BeFree Detail
0.006 irritable bowel syndrome NA BeFree,GAD Detail
0.126 ischemia NA BeFree,CTD_human,GAD Detail
0.001 arthropathy NA BeFree Detail
<0.001 Kartagener syndrome NA BeFree Detail
0.001 Keloid NA BeFree Detail
<0.001 keratitis Expression of IL-8, IL-6 and IL-1β in tears as a main characteristic of the immu... BeFree 25741769 Detail
<0.001 keratoconus We analyzed the gene expression levels of the key proteins LOX, collagens (COL I... BeFree 25593510 Detail
<0.001 Kidney Calculi NA BeFree Detail
0.009 Kidney Diseases NA BeFree,GAD,LHGDN Detail
0.006 Kidney Failure, Acute NA BeFree,GAD Detail
0.153 Kidney Failure, Chronic NA BeFree,CTD_human,GAD,LHGDN Detail
0.129 Premature Obstetric Labor NA CTD_human,GAD Detail
<0.001 Pain in lower limb NA BeFree Detail
<0.001 Leg Ulcer IL-1β +3954C>T SNP was associated with increased risk of osteonecrosis, elevated... BeFree 25595815 Detail
<0.001 Legg-Calve-Perthes disease Association of gene variants in TLR4 and IL-6 genes with Perthes disease. BeFree 25233690 Detail
0.003 Fibroid Tumor NA LHGDN Detail
0.120 leishmaniasis NA CTD_human Detail
0.003 Leishmaniasis, Cutaneous NA BeFree,GAD Detail
<0.001 Infection by Leishmania braziliensis NA BeFree Detail
0.120 Leishmaniasis, Visceral NA BeFree,CTD_human Detail
0.003 leprosy NA BeFree,GAD Detail
0.002 leptospirosis NA GAD Detail
0.007 leukemia Microenvironmental interleukin-6 suppresses toll-like receptor signaling in huma... BeFree,LHGDN 26041742 Detail
0.127 chronic lymphocytic leukemia Chromatin immunoprecipitation (ChIP) and an electoromobility shift assay (EMSA) ... BeFree,CTD_human,GAD 24836891 Detail
0.127 chronic lymphocytic leukemia Our results provide evidence that the regulation of IL-6, IL-10, c-Jun, and STAT... BeFree,CTD_human,GAD 25477266 Detail
0.127 chronic lymphocytic leukemia These results suggest IL-6 can act as tumor suppressor in CLL by inhibiting TLR-... BeFree,CTD_human,GAD 26041742 Detail
<0.001 Acute Erythroblastic Leukemia Therefore, have investigated whether or not the expression levels, of selected g... BeFree 24961464 Detail
0.001 hairy cell leukemia NA BeFree Detail
0.003 lymphoid leukemia NA LHGDN Detail
0.002 Acute lymphocytic leukemia NA BeFree Detail
<0.001 Leukemia, Lymphocytic, Acute, L1 NA BeFree Detail
<0.001 Acute Megakaryocytic Leukemias NA BeFree Detail
0.017 Leukemia, Myelocytic, Acute NA BeFree,GAD,LHGDN Detail
0.001 myeloid leukemia NA BeFree Detail
0.002 Myeloid Leukemia, Chronic NA BeFree Detail
0.001 Leukemia, Plasma Cell NA BeFree Detail
0.001 acute promyelocytic leukemia NA BeFree Detail
<0.001 Leukemia, T-Cell NA BeFree Detail
0.001 Adult T-Cell Lymphoma/Leukemia NA BeFree Detail
0.010 Leukomalacia, Periventricular NA BeFree,GAD Detail
<0.001 lichen planus NA BeFree Detail
0.003 lipodystrophy NA BeFree,GAD Detail
<0.001 listeriosis NA BeFree Detail
<0.001 hyperhomocysteinemia All subjects were genotyped for 13 polymorphic variants in the genes of xenobiot... BeFree 23107763 Detail
0.126 liver cirrhosis We prospectively assessed the influence of 6 single nucleotide polymorphisms (SN... BeFree,CTD_human,GAD 24751829 Detail
0.123 Liver Cirrhosis, Alcoholic NA BeFree,CTD_human,GAD Detail
0.007 Liver diseases A significantly higher frequency of IL6 and TGF-β double-high patients was detec... BeFree,GAD,LHGDN 24905921 Detail
0.003 Alcoholic Liver Diseases NA BeFree,GAD Detail
0.034 Liver neoplasms These results indicate that PML modulates IL-6-induced STAT3 activation and hepa... BeFree,GAD,LHGDN 25892518 Detail
0.083 Lung diseases NA BeFree,GAD,RGD Detail
0.029 Chronic Obstructive Airway Disease Our findings suggest that IL6 and SOCS3 play important roles in COPD and have th... BeFree,GAD,LHGDN 25535123 Detail
0.139 Lung Neoplasms NA BeFree,CTD_human,GAD,LHGDN Detail
0.004 Lupus Vulgaris NA BeFree,GAD Detail
<0.001 Lupus Erythematosus, Cutaneous NA BeFree Detail
0.004 Lupus Erythematosus, Discoid NA BeFree,GAD Detail
0.150 Lupus Erythematosus, Systemic In addition, blocking the autocrine-loop of IL-6 in SLE B cells with an anti-IL-... BeFree,CTD_human,GAD,LHGDN 24117194 Detail
0.150 Lupus Erythematosus, Systemic Interleukin-6, interleukin-1 gene cluster and interleukin-1 receptor polymorphis... BeFree,CTD_human,GAD,LHGDN 25109676 Detail
0.150 Lupus Erythematosus, Systemic Increased tumor necrosis factor α (TNF-α) in SLE serum significantly inhibited t... BeFree,CTD_human,GAD,LHGDN 25762184 Detail
0.150 Lupus Erythematosus, Systemic The cytokines IL-6 and IL-10 are produced by cells of the adaptive and innate ar... BeFree,CTD_human,GAD,LHGDN 25794663 Detail
0.002 lupus nephritis NA BeFree Detail
0.003 Lyme disease NA LHGDN Detail
0.005 Lymphatic Metastasis NA GAD Detail
<0.001 lymphedema NA BeFree Detail
0.011 lymphoma NA BeFree,GAD,LHGDN Detail
0.005 Lymphoproliferative Disorders NA BeFree,GAD Detail
0.009 Waldenstrom Macroglobulinemia NA BeFree,GAD,LHGDN Detail
<0.001 Macular Edema, Cystoid NA BeFree Detail
<0.001 Homocysteinemia All subjects were genotyped for 13 polymorphic variants in the genes of xenobiot... BeFree 23107763 Detail
0.002 malaria Participants with genotype combinations GC/CC/GG/GG and GG/CT/GG/GG (DDX39B-22/D... BeFree 25038626 Detail
<0.001 Malaria, Cerebral NA BeFree Detail
<0.001 Malaria, Vivax DDX39B (BAT1), TNF and IL6 gene polymorphisms and association with clinical outc... BeFree 25038626 Detail
<0.001 Malignant hyperpyrexia due to anesthesia NA BeFree Detail
<0.001 Primary malignant neoplasm of liver NA BeFree Detail
0.013 Malignant neoplasm of stomach Clinical impact of the HGF/MET pathway activation in patients with advanced gast... BeFree,GAD 24663077 Detail
0.013 Malignant neoplasm of stomach Additionally, signal transducer and activator of transcription 3 (STAT3) was als... BeFree,GAD 25234193 Detail
0.013 Malignant neoplasm of stomach IL-33 promotes gastric cancer cell invasion and migration by stimulating the sec... BeFree,GAD 25655003 Detail
<0.001 mastocytosis NA BeFree Detail
0.003 measles NA BeFree,GAD Detail
<0.001 medulloblastoma NA BeFree Detail
0.020 melanoma These results suggest that SPINT2 is associated with tumor-suppressive functions... BeFree,GAD,LHGDN 25910030 Detail
<0.001 Melanosis NA BeFree Detail
0.001 meningioma NA BeFree Detail
<0.001 meningitis In this study we investigated the role of IL-6 in Cryptococcus meningitis. BeFree 25740137 Detail
0.120 aseptic meningitis NA CTD_human Detail
0.080 Meningitis, Pneumococcal NA RGD Detail
<0.001 Meningococcal Infections NA BeFree Detail
<0.001 Meningococcemia NA BeFree Detail
0.003 Mental Retardation NA BeFree,GAD Detail
0.001 Mesothelioma NA BeFree Detail
0.001 Metabolic Diseases Through this activation, proinflammatory cytokines, such as Interleukin-6 (IL-6)... BeFree 25993353 Detail
0.002 Metaplasia NA GAD Detail
<0.001 Mixed Salivary Gland Tumor The interleukin-6 (IL-6)/Janus kinase (JAK)/signal transducer and activator of t... BeFree 26061266 Detail
<0.001 Monoclonal Gammopathy of Undetermined Significance NA BeFree Detail
0.005 Mouth Neoplasms NA GAD Detail
0.003 Mucocutaneous Lymph Node Syndrome Kawasaki disease was associated with higher IL-17A and IL-6, a cytokine profile ... BeFree,GAD 25585854 Detail
0.226 multiple myeloma In this study, we examined changes in gene expression profile in human mesenchym... BeFree,CTD_human,GAD,LHGDN 24410591 Detail
0.226 multiple myeloma Down-regulation of interleukin 6 (IL6) by berberine might lead to inhibition of ... BeFree,CTD_human,GAD,LHGDN 25000828 Detail
0.226 multiple myeloma A HGF/cMET autocrine loop is operative in multiple myeloma bone marrow endotheli... BeFree,CTD_human,GAD,LHGDN 25212607 Detail
0.226 multiple myeloma Thalidomide (Thal) has been used to treat multiple myeloma due to its inhibitory... BeFree,CTD_human,GAD,LHGDN 25749497 Detail
0.226 multiple myeloma In this study, we demonstrated that Senp1 is overexpressed and induced by IL-6 i... BeFree,CTD_human,GAD,LHGDN 25791478 Detail
0.009 Multiple Organ Failure NA GAD Detail
0.037 multiple sclerosis Furthermore, the production of IL-17 and IL-6 by MS-derived T cells was directly... BeFree,GAD,LHGDN 24882215 Detail
0.037 multiple sclerosis Taken together, our data indicate an important role for miR26a in maintaining th... BeFree,GAD,LHGDN 25362566 Detail
0.037 multiple sclerosis Nonapoptotic and extracellular activity of granzyme B mediates resistance to reg... BeFree,GAD,LHGDN 25637022 Detail
0.037 multiple sclerosis Seeking balance: Potentiation and inhibition of multiple sclerosis autoimmune re... BeFree,GAD,LHGDN 25794663 Detail
0.003 mumps NA BeFree,GAD Detail
0.001 muscular atrophy NA BeFree Detail
<0.001 muscular dystrophy NA BeFree Detail
0.002 Musculoskeletal Diseases NA GAD Detail
0.004 myasthenia gravis B cells produce less IL-10, IL-6 and TNF-α in myasthenia gravis. BeFree,LHGDN 25518708 Detail
0.002 Mycobacterium avium-intracellulare Infection NA GAD Detail
<0.001 Mycobacterium Infections NA BeFree Detail
<0.001 Mycoplasma Infections NA BeFree Detail
0.002 Mycoses Gram-positive bacterial and fungal infections did not cause a marked increase in... BeFree 25526183 Detail
0.002 Mycoses The infected IL-6(-/-) mice had significantly larger brain fungal burdens than w... BeFree 25740137 Detail
0.003 Myelodysplasia NA BeFree,GAD Detail
<0.001 Myelomonocytic leukemia NA BeFree Detail
0.190 myocardial infarction IL6R haplotype associations with C-reactive protein (CRP), fibrinogen, IL6, solu... BeFree,CTD_human,GAD,LHGDN 25781951 Detail
0.190 myocardial infarction HGF/Met has beneficial effects against myocardial infarction and endothelial dys... BeFree,CTD_human,GAD,LHGDN 26561593 Detail
<0.001 myocarditis NA BeFree Detail
0.003 Myoclonus NA LHGDN Detail
0.003 myoepithelioma NA LHGDN Detail
<0.001 Myotonic dystrophy NA BeFree Detail
<0.001 Myxoma NA BeFree Detail
0.003 Nasal Polyps The levels of IL-6, soluble IL-6 receptor (sIL-6R), soluble gp130 (sgp130), and ... BeFree 26266960 Detail
0.120 Necrosis NA CTD_human Detail
0.122 Neoplasm Invasiveness NA CTD_human,GAD Detail
0.150 Neoplasm Metastasis In transformed cells, enforced expression of SOCS3 or interfering with IL6 pathw... BeFree,CTD_human,LHGDN 24531711 Detail
0.150 Neoplasm Metastasis The neutralizing assays suggested that interleukin-6 (IL-6) had an indispensable... BeFree,CTD_human,LHGDN 24704835 Detail
0.150 Neoplasm Metastasis Interleukin-6 (IL-6) is an important cytokine that activates the signal transduc... BeFree,CTD_human,LHGDN 25234193 Detail
0.150 Neoplasm Metastasis More intriguingly, by skewing macrophages polarization away from the M1- to a tu... BeFree,CTD_human,LHGDN 25313135 Detail
0.150 Neoplasm Metastasis NK1 induces all three HGF activities at modestly reduced potency, whereas NK2 st... BeFree,CTD_human,LHGDN 26231668 Detail
0.002 Neoplasm Recurrence, Local NA GAD Detail
<0.001 nephritis NA BeFree Detail
<0.001 nephroblastoma NA BeFree Detail
0.002 nephrotic syndrome NA GAD Detail
0.003 nervous system disorder NA BeFree,GAD Detail
0.008 neuroblastoma NA BeFree,GAD Detail
<0.001 acoustic neuroma The results of the current study demonstrated that pro-inflammatory cytokines, i... BeFree 25738867 Detail
<0.001 neuromyelitis optica NA BeFree Detail
0.003 neutropenia NA BeFree,GAD Detail
<0.001 Melanocytic nevus NA BeFree Detail
0.005 Obesity, Morbid NA BeFree,GAD Detail
<0.001 Odontogenic Tumors NA BeFree Detail
<0.001 optic neuritis NA BeFree Detail
<0.001 orbit (eye disorders) NA BeFree Detail
<0.001 Osteitis NA BeFree Detail
0.026 Degenerative polyarthritis A meta-analysis was conducted on the association between the IL-6 polymorphism a... BeFree,GAD,LHGDN 24985590 Detail
0.026 Degenerative polyarthritis Several genes, including IL-6 encoding pro-inflammatory cytokines, are involved ... BeFree,GAD,LHGDN 25022967 Detail
0.026 Degenerative polyarthritis Possible interactions of the TNFα SNPs with variants in the previously reported ... BeFree,GAD,LHGDN 25252624 Detail
0.026 Degenerative polyarthritis Using rabbit and human synovial fibroblast cell lines, we examined the effects o... BeFree,GAD,LHGDN 25496568 Detail
0.026 Degenerative polyarthritis These findings implicate miR-9-mediated suppression of MCPIP-1 in the pathogenes... BeFree,GAD,LHGDN 25917063 Detail
0.026 Degenerative polyarthritis These results support our hypothesis that miR-139-mediated downregulation of MCP... BeFree,GAD,LHGDN 26450708 Detail
0.006 Osteoarthritis of hip Transforming growth factor-β1 (TGF-beta1) and interleukin-6 (IL-6) are included ... BeFree,GAD 25603974 Detail
0.003 osteomyelitis NA BeFree,GAD Detail
0.002 Osteopenia NA GAD Detail
0.137 osteoporosis Association of interleukin-6 gene polymorphisms with hand osteoarthritis and han... BeFree,CTD_human,GAD 25022967 Detail
0.140 Osteoporosis, Postmenopausal NA BeFree,CTD_human,GAD Detail
0.004 osteosarcoma NA BeFree Detail
<0.001 Ear Inflammation NA BeFree Detail
0.090 otitis media NA BeFree,GAD,RGD Detail
0.009 ovarian carcinoma HGF/c-Met axis drives cancer aggressiveness in the neo-adjuvant setting of ovari... BeFree 24952592 Detail
0.009 ovarian carcinoma In addition, we found that the expression level of IL6 was correlated with activ... BeFree 25319391 Detail
0.009 ovarian carcinoma Ovarian cancer ascites were collected from patients, and we found that primary C... BeFree 25658637 Detail
0.009 ovarian carcinoma Adaptive Upregulation of EGFR Limits Attenuation of Tumor Growth by Neutralizing... BeFree 25670170 Detail
0.009 ovarian carcinoma HGF expression in four ovarian cancer cell lines was evaluated by using semi-qua... BeFree 26335595 Detail
0.003 Ovarian Cysts NA BeFree,GAD Detail
0.002 Ovarian Diseases NA BeFree Detail
0.001 Pain For other patients, the IL6 -174 GG genotype predicted moderate/severe pain (OR,... BeFree 25469832 Detail
0.001 Pain At the same location of pain assessment and fibroblast sampling, in situ immunoh... BeFree 25679469 Detail
0.002 Pain, Postoperative NA GAD Detail
<0.001 Pustulosis of Palms and Soles NA BeFree Detail
<0.001 Pancreatic Diseases NA BeFree Detail
0.021 Pancreatic Neoplasm NA GAD,LHGDN Detail
0.003 pancreatitis Administration of MSCs alone significantly reduced pancreatic injury and inflamm... BeFree,GAD 25120736 Detail
<0.001 pancytopenia NA BeFree Detail
<0.001 Parainfluenza NA BeFree Detail
<0.001 Paraneoplastic Syndromes Thus, IL-6 plays pivotal roles in both paraneoplastic syndrome and the oncogenes... BeFree 26165403 Detail
0.003 tropical spastic paraparesis NA BeFree,GAD Detail
<0.001 Paresis NA BeFree Detail
0.129 Parkinson disease NA CTD_human,GAD Detail
0.003 Pelvic Pain NA BeFree,GAD Detail
0.008 pemphigus NA BeFree,GAD,LHGDN Detail
0.003 pemphigus vulgaris NA BeFree,GAD Detail
0.005 Peptic Ulcer miR-155 and miR-146b negatively regulates IL6 in Helicobacter pylori (cagA+) inf... BeFree,GAD 25753878 Detail
0.003 familial Mediterranean fever NA BeFree,GAD Detail
0.029 Periodontal Diseases NA BeFree,GAD,LHGDN Detail
0.005 Periodontal Pocket NA GAD Detail
0.045 periodontitis Relationships between IL-6 gene polymorphism, low BMD and periodontitis in postm... BeFree,GAD,LHGDN 25576892 Detail
0.011 Periodontitis, Juvenile NA BeFree,GAD,LHGDN Detail
0.120 Peripheral neuropathy NA BeFree,CTD_human Detail
0.002 Peritoneal Neoplasms NA GAD Detail
0.001 peritonitis NA BeFree Detail
<0.001 Polymorphous light eruption NA BeFree Detail
0.002 Picornaviridae Infections NA GAD Detail
0.002 pituitary adenoma NA BeFree Detail
0.004 Pituitary Diseases NA BeFree Detail
<0.001 Pituitary Neoplasms NA BeFree Detail
0.009 plasmacytoma NA BeFree,GAD Detail
<0.001 Pleural effusion disorder NA BeFree Detail
0.120 pleurisy NA CTD_human Detail
<0.001 Pneumococcal Infections NA BeFree Detail
0.005 pneumoconiosis NA BeFree,GAD Detail
0.126 pneumonia Associations of three well-characterized polymorphisms in the IL-6 and IL-10 gen... BeFree,CTD_human,LHGDN 25708204 Detail
<0.001 Lobar Pneumonia NA BeFree Detail
0.013 polycystic ovary syndrome Association of TNF-alpha, IL-6 and IL-1beta gene polymorphisms with polycystic o... BeFree,GAD,LHGDN 25634659 Detail
0.013 polycystic ovary syndrome The results of the meta-analysis suggest positive associations between the TNF-α... BeFree,GAD,LHGDN 25690158 Detail
<0.001 polycythemia vera NA BeFree Detail
0.008 polymyalgia rheumatica NA BeFree,GAD Detail
0.003 polyps NA BeFree,LHGDN Detail
<0.001 Post-kala-azar dermal leishmaniasis NA BeFree Detail
0.019 Postoperative Complications NA GAD Detail
<0.001 Poxviridae Infections NA BeFree Detail
<0.001 Prader-Willi syndrome NA BeFree Detail
0.022 pre-eclampsia NA GAD,LHGDN Detail
0.003 Precancerous Conditions EGCG rapidly induced mitochondria-localized reactive oxygen species in human ora... BeFree,GAD 25329972 Detail
0.005 Pregnancy Complications NA BeFree,GAD Detail
0.120 Pregnancy Complications, Cardiovascular NA CTD_human Detail
0.002 Pregnancy Complications, Hematologic NA GAD Detail
0.002 Pregnancy Complications, Infectious NA GAD Detail
0.003 Preleukemia NA BeFree,GAD Detail
<0.001 prolactinoma NA BeFree Detail
0.156 Prostatic Neoplasms IL-6 can convert non-ALDH(high) cells to ALDH(high) cells in prostate cancer cel... BeFree,CTD_human,LHGDN 25261365 Detail
0.156 Prostatic Neoplasms Together with our previous observation that EGR3 is highly expressed in prostate... BeFree,CTD_human,LHGDN 25633035 Detail
0.003 prostatitis NA BeFree,GAD Detail
0.002 proteinuria NA GAD Detail
<0.001 Pseudorabies NA BeFree Detail
0.136 psoriasis IL6 -174G>C polymorphism is associated with an increased risk of psoriasis but n... BeFree,CTD_human,GAD,LHGDN 25357087 Detail
<0.001 Psychotic Disorders NA BeFree Detail
<0.001 pterygium NA BeFree Detail
0.002 Puerperal Disorders NA GAD Detail
<0.001 pulmonary alveolar proteinosis NA BeFree Detail
<0.001 pulmonary edema The protective effects of bLF against hyperoxia were further confirmed by signif... BeFree 24842100 Detail
0.003 pulmonary embolism NA BeFree,GAD Detail
0.001 pulmonary emphysema In vitro studies revealed that Thal decreased 1) the expression of IL-1β and IL-... BeFree 25749497 Detail
0.128 pulmonary fibrosis A 10-fold reduction in IL-6 and a 5-fold decrease in hyaluronan, both linked to ... BeFree,CTD_human,GAD 25318478 Detail
0.128 pulmonary fibrosis Furthermore, the DEGs of SOCS3, IL4, IL18R1, IL1R1, and IL6 were participated in... BeFree,CTD_human,GAD 25535123 Detail
<0.001 Henoch-Schoenlein purpura NA BeFree Detail
0.002 pyelonephritis NA GAD Detail
<0.001 pyruvate carboxylase deficiency disease IL-6 levels in plasma were significantly (p<0.001) decreased in hwt-APC and hS36... BeFree 25032959 Detail
0.005 Q fever NA GAD Detail
<0.001 Radicular Cyst NA BeFree Detail
<0.001 Rales NA BeFree Detail
0.005 Rectal Neoplasms NA GAD Detail
0.002 reflex sympathetic dystrophy NA GAD Detail
0.010 kidney failure NA BeFree,GAD Detail
<0.001 renal osteodystrophy NA BeFree Detail
0.202 Reperfusion Injury NA CTD_human,GAD,RGD Detail
0.001 Respiratory Distress Syndrome, Newborn NA BeFree Detail
0.007 Respiratory Distress Syndrome, Adult NA BeFree,GAD,LHGDN Detail
0.120 Respiratory Hypersensitivity NA CTD_human Detail
0.003 Respiratory Syncytial Virus Infections NA BeFree,GAD Detail
0.010 Respiratory Tract Infections NA BeFree,GAD,LHGDN Detail
0.005 retinal artery occlusion NA BeFree,GAD,LHGDN Detail
<0.001 retinal detachment NA BeFree Detail
<0.001 Retinal Diseases IL-1β +3954C>T SNP was associated with increased risk of osteonecrosis, elevated... BeFree 25595815 Detail
<0.001 Retinal Necrosis Syndrome, Acute NA BeFree Detail
0.085 retinal vein occlusion NA GAD,LHGDN,RGD Detail
<0.001 retinoblastoma NA BeFree Detail
<0.001 Retroviridae Infections NA BeFree Detail
0.002 Rhabdomyolysis NA GAD Detail
<0.001 rhabdomyosarcoma NA BeFree Detail
<0.001 Rheumatism NA BeFree Detail
0.003 rheumatic heart disease NA BeFree,GAD Detail
0.004 rubella Our analysis revealed evidence for multiple associations between genetic variant... BeFree,GAD 24945853 Detail
0.013 sarcoidosis NA BeFree,GAD,LHGDN Detail
0.130 Kaposi sarcoma NA BeFree,CTD_human,GAD,LHGDN Detail
0.127 schizophrenia We report significant increases in PPARγ, SREBP1, IL-6 and TNFα, and decreases i... BeFree,CTD_human,GAD 25433960 Detail
0.127 schizophrenia Family-based association study of interleukin 6 (IL6) and its receptor (IL6R) fu... BeFree,CTD_human,GAD 26198920 Detail
<0.001 paranoid schizophrenia NA BeFree Detail
0.006 Sciatica NA BeFree,GAD,LHGDN Detail
<0.001 localized scleroderma NA BeFree Detail
0.012 systemic scleroderma NA BeFree,GAD Detail
0.003 Scoliosis, unspecified NA BeFree,LHGDN Detail
<0.001 scrub typhus NA BeFree Detail
0.121 Seizures NA BeFree,CTD_human Detail
0.014 Septicemia Patients with postoperative sepsis were significantly (p = 0.002) more likely to... BeFree 24944154 Detail
0.014 Septicemia The protection of female hearts against the dysfunction associated with sepsis i... BeFree 24945834 Detail
0.014 Septicemia Plasma was analysed by ELISA for thrombin-antithrombin complex (TAT), D-dimer as... BeFree 25030319 Detail
0.014 Septicemia Analysis of 1163 miRNAs from PBMCs revealed that miR-182, miR-143, miR-145, miR-... BeFree 25265569 Detail
0.014 Septicemia In summary, this work provides the first in vivo evidence that administering BMM... BeFree 25337817 Detail
0.014 Septicemia Association between IL-6-174G/C polymorphism and the risk of sepsis and mortalit... BeFree 25734339 Detail
0.014 Septicemia The combination of markers (hs-CRP, PCT, and IL-6) is better than single markers... BeFree 25881528 Detail
0.005 Shock NA GAD,LHGDN Detail
0.200 Shock, Hemorrhagic NA CTD_human,RGD Detail
0.010 Septic Shock NA GAD,LHGDN Detail
0.124 Dermatologic disorders NA BeFree,CTD_human,GAD Detail
<0.001 Skin lesion Neutralization of tumor necrosis factor-α and IL-6 (both downstream of IL-17A) r... BeFree 25341795 Detail
0.005 Skin Neoplasms NA BeFree,GAD Detail
0.002 Skin Ulcer NA GAD Detail
<0.001 Sleep disturbances NA BeFree Detail
<0.001 Soft Tissue Neoplasms NA BeFree Detail
0.006 Spinal Cord Diseases NA BeFree,GAD,LHGDN Detail
0.002 Spinal Diseases NA GAD Detail
<0.001 spondylitis NA BeFree Detail
0.003 ankylosing spondylitis NA BeFree,GAD Detail
<0.001 Staphylococcal Skin Infections NA BeFree Detail
0.151 Stomach Neoplasms NA BeFree,CTD_human,GAD,LHGDN Detail
0.003 gastric ulcer NA BeFree,GAD Detail
0.013 aphthous stomatitis NA GAD,LHGDN Detail
0.005 Streptococcal Infections NA GAD Detail
0.003 post-traumatic stress disorder While the elderly group exhibited robust changes in immune activity such as incr... BeFree,LHGDN 24977331 Detail
<0.001 Stress, Psychological NA BeFree Detail
0.170 Cerebrovascular accident Our findings have implications for the use of cancer therapies that target VEGF ... BeFree,CTD_human,GAD,LHGDN 26081809 Detail
0.003 subacute sclerosing panencephalitis NA LHGDN Detail
0.003 Subarachnoid Hemorrhage NA BeFree,GAD Detail
0.009 sudden infant death syndrome NA BeFree,GAD,LHGDN Detail
<0.001 synovial sarcoma NA BeFree Detail
0.001 synovitis NA BeFree Detail
0.003 Tachycardia NA LHGDN Detail
0.012 Giant Cell Arteritis NA BeFree,GAD,LHGDN Detail
0.003 Temporomandibular Joint Disorders NA LHGDN Detail
<0.001 tetanus NA BeFree Detail
0.002 Thinness NA GAD Detail
0.002 Thoracic Neoplasms NA GAD Detail
<0.001 thromboangiitis obliterans NA BeFree Detail
<0.001 Thrombocythemia, Essential We investigated the role of activated B cells in thrombopoiesis through the prod... BeFree 24898769 Detail
<0.001 Thromboembolism Single nucleotide polymorphisms in interleukin-6 and their association with veno... BeFree 25625484 Detail
0.005 thrombosis NA GAD,LHGDN Detail
<0.001 Thyroid Diseases NA BeFree Detail
0.120 Thyroid Neoplasm NA CTD_human Detail
0.003 Thyroid Nodule NA LHGDN Detail
0.003 trachoma NA BeFree,GAD Detail
<0.001 Tremor When early stage and late stage CSF cytokines were compared, IL-10 and IL-6 were... BeFree 26090964 Detail
0.002 trypanosomiasis NA GAD Detail
<0.001 African Trypanosomiasis NA BeFree Detail
<0.001 Chagas disease NA BeFree Detail
<0.001 Tuberculosis, Miliary NA BeFree Detail
0.004 Tuberculosis, Pulmonary Independent and joint effects of the IL-6 and IL-10 gene polymorphisms in pulmon... BeFree,GAD 25299090 Detail
0.004 Tuberculosis, Pulmonary We also performed the analyses by sample types in IL-6 -174 C/G polymorphism, an... BeFree,GAD 26169021 Detail
0.002 Unipolar Depression NA BeFree Detail
<0.001 Erythema NA BeFree Detail
<0.001 Upper Respiratory Infections NA BeFree Detail
0.006 uremia To investigate microvessel density (MVD), vascular endothelial growth factor (VE... BeFree,LHGDN 25000894 Detail
0.004 urinary tract infection NA BeFree,GAD Detail
<0.001 urticaria pigmentosa NA BeFree Detail
0.002 Uterine Diseases NA GAD Detail
0.082 uveitis New cytokine inhibitors targeting IL-1 and IL-6 appear to be effective especiall... BeFree,RGD 26487500 Detail
0.002 anterior uveitis NA GAD Detail
0.009 Vascular Diseases NA BeFree,GAD,LHGDN Detail
0.002 Venous Thrombosis NA GAD Detail
0.003 Ventricular fibrillation NA BeFree,LHGDN Detail
0.008 Virus Diseases NA BeFree,GAD Detail
0.003 vitiligo NA BeFree,LHGDN Detail
<0.001 intestinal volvulus Isolated PBMCs from O. volvulus-infected individuals (164 MF(+) and 46 a-MF) and... BeFree 25889652 Detail
0.002 Weight Gain NA GAD Detail
<0.001 Wheezing NA BeFree Detail
<0.001 Wiskott-Aldrich syndrome NA BeFree Detail
<0.001 Yersinia infections NA BeFree Detail
<0.001 Zollinger-Ellison syndrome NA BeFree Detail
0.002 Blood Loss, Surgical NA GAD Detail
<0.001 epidermolysis bullosa acquisita NA BeFree Detail
<0.001 epidermolysis bullosa dystrophica We found a significant increase in interleukin (IL)-1β plasmatic levels of DEB (... BeFree 26496255 Detail
<0.001 epidermolysis bullosa simplex We found a significant increase in interleukin (IL)-1β plasmatic levels of DEB (... BeFree 26496255 Detail
0.019 Helicobacter Infections NA GAD Detail
0.005 B-Cell Lymphomas NA BeFree,LHGDN Detail
0.003 diffuse large B-cell lymphoma CD38 and interleukin 6 gene polymorphism in egyptians with diffuse large B-cell ... BeFree,GAD 25564959 Detail
<0.001 Lymphoma, Large-Cell, Follicular NA BeFree Detail
<0.001 T-Cell Lymphoma NA BeFree Detail
0.005 Lymphoma, T-Cell, Cutaneous NA BeFree,GAD,LHGDN Detail
<0.001 peripheral T-cell lymphoma NA BeFree Detail
<0.001 Pleural Effusion, Malignant Targeting VEGF and interleukin-6 for controlling malignant effusion of primary e... BeFree 25304617 Detail
<0.001 ovarian hyperstimulation syndrome NA BeFree Detail
0.015 Peripheral Vascular Diseases NA BeFree,GAD Detail
<0.001 Familial benign pemphigus NA BeFree Detail
0.002 severe combined immunodeficiency NA BeFree Detail
<0.001 Central Nervous System Neoplasms NA BeFree Detail
0.006 bacterial vaginosis The levels of interleukin-1α (IL-1α), IL-1β, IL-6, IL-12(p70), and IL-8 were ele... BeFree,GAD 25761460 Detail
<0.001 gestational diabetes NA BeFree Detail
<0.001 Diffuse cutaneous leishmaniasis NA BeFree Detail
<0.001 Toxoplasmosis, Cerebral NA BeFree Detail
<0.001 Neurofibrillary degeneration (morphologic abnormality) NA BeFree Detail
<0.001 POEMS syndrome NA BeFree Detail
<0.001 Polyendocrinopathies, Autoimmune The ability of PGA to induce TNF-α and IL-6 was retained in TLR4(-/-) but not TL... BeFree 26195551 Detail
<0.001 Gram-Negative Bacterial Infections Overall, 82.9% of children with Gram-negative bacterial infections were accompan... BeFree 25526183 Detail
<0.001 Meningitis, Fungal Lack of IL-6 increases blood-brain barrier permeability in fungal meningitis. BeFree 25740137 Detail
0.001 essential hypertension NA BeFree Detail
<0.001 Encephalopathies NA BeFree Detail
<0.001 Chills NA BeFree Detail
<0.001 Liver failure Interleukin-6 upregulates Th17 response via mTOR/STAT3 pathway in acute-on-chron... BeFree 24366287 Detail
<0.001 Synovial Cyst NA BeFree Detail
<0.001 Pyogenic granuloma NA BeFree Detail
0.120 polymyositis NA BeFree,CTD_human Detail
0.003 Plasmacytosis NA BeFree Detail
0.001 acute leukemia NA BeFree Detail
<0.001 Acute appendicitis NOS (disorder) NA BeFree Detail
<0.001 Chronic gastritis NA BeFree Detail
0.001 Depressive Symptoms Effects of chronic interpersonal stress exposure on depressive symptoms are mode... BeFree 25596176 Detail
<0.001 Secondary generalized epilepsy NA BeFree Detail
<0.001 cataract NA BeFree Detail
<0.001 benign neoplasm The interleukin-6 (IL-6)/Janus kinase (JAK)/signal transducer and activator of t... BeFree 26061266 Detail
<0.001 Chronic sinusitis Age-related increased prevalence of asthma and nasal polyps in chronic rhinosinu... BeFree 26266960 Detail
<0.001 Acute Cholecystitis NA BeFree Detail
0.011 Pancreatitis, Chronic NA BeFree,GAD,LHGDN Detail
0.003 Epstein-Barr Virus Infections The levels of inflammatory cytokines IL-6, IL-8, IL-1β and TNF-α in the HNE2 cel... BeFree,GAD 25891128 Detail
<0.001 Left Ventricular Hypertrophy NA BeFree Detail
<0.001 Deep Vein Thrombosis NA BeFree Detail
<0.001 Cholestatic hepatitis NA BeFree Detail
<0.001 Small cell carcinoma of lung NA BeFree Detail
0.003 Migraine Disorders NA BeFree,GAD Detail
0.080 sciatic neuropathy NA RGD Detail
0.161 Premature Birth NA CTD_human,GAD,LHGDN Detail
<0.001 Oral Cavity Carcinoma NA BeFree Detail
<0.001 renal fibrosis NA BeFree Detail
0.008 Intracranial Hemorrhages NA GAD,LHGDN Detail
0.126 Myocardial Ischemia NA BeFree,CTD_human,GAD Detail
<0.001 Bone marrow depression NA BeFree Detail
<0.001 Coronary Occlusion NA BeFree Detail
<0.001 Pleocytosis NA BeFree Detail
<0.001 Deep thrombophlebitis NA BeFree Detail
0.002 Adenocarcinoma of lung (disorder) NA BeFree Detail
0.002 esophageal carcinoma NA BeFree Detail
<0.001 Joint swelling NA BeFree Detail
0.001 Idiopathic pulmonary hypertension NA BeFree Detail
<0.001 Chronic glomerulonephritis NA BeFree Detail
<0.001 Toxoplasmosis chorioretinitis NA BeFree Detail
0.002 Malignant neoplasm of mouth In conclusion, IL-6 -DNMT3b axis could be used to predict the prognosis of oral ... BeFree 24625449 Detail
<0.001 Malignant neoplasm of nasopharynx NA BeFree Detail
0.012 systemic scleroderma We aimed to investigate whether the functional genetic variants rs8192284 and rs... BeFree 22742541 Detail
0.011 Diabetes IL6R genetic variations, especially SNP7 (rs8192284, Asp358Ala), were significan... BeFree 17898129 Detail
0.038 diabetes mellitus IL6R genetic variations, especially SNP7 (rs8192284, Asp358Ala), were significan... BeFree 17898129 Detail
0.001 Secondary malignant neoplasm of lung NA BeFree Detail
0.001 Secondary malignant neoplasm of bone HGF and TGFβ1 of bone-metastasis microenvironment acted co-ordinately, influenci... BeFree 26041563 Detail
0.002 migraine with aura NA GAD Detail
<0.001 proliferative diabetic retinopathy NA BeFree Detail
0.003 acute myocardial infarction NA BeFree Detail
<0.001 Old myocardial infarction NA BeFree Detail
<0.001 Streptococcal pneumonia NA BeFree Detail
<0.001 allergic asthma NA BeFree Detail
<0.001 Intervertebral disc disorder NA BeFree Detail
0.003 Intervertebral Disc Degeneration NA BeFree,GAD Detail
0.001 adrenoleukodystrophy NA BeFree Detail
0.003 Malnutrition Malnutrition is more frequently associated in children with IL-6 174 G allele ca... BeFree,GAD 25023587 Detail
0.002 AIDS-Related Opportunistic Infections NA GAD Detail
<0.001 Prion Diseases NA BeFree Detail
0.003 Immunoglobulin A deficiency (disorder) NA BeFree,GAD Detail
0.001 Liver Failure, Acute NA BeFree Detail
<0.001 porphyria cutanea tarda NA BeFree Detail
0.120 Mitochondrial Myopathies NA CTD_human Detail
<0.001 Cicatrix, Hypertrophic NA BeFree Detail
0.002 Dermatitis, Allergic Contact NA GAD Detail
0.120 Lichenoid Eruptions NA CTD_human Detail
0.002 Aneurysm, Ruptured NA GAD Detail
0.021 Aortic Aneurysm, Abdominal NA BeFree,GAD,LHGDN Detail
<0.001 Agenesis of corpus callosum Moreover, IL-6 expression decreased significantly in SMG ACCs compared with that... BeFree 24456477 Detail
<0.001 Autoimmune thyroid disease Polymorphisms in the TNFA and IL6 genes represent risk factors for autoimmune th... BeFree 25127106 Detail
0.010 Tumor Progression The microenvironment of glioblastoma (GBM) contains high levels of inflammatory ... BeFree 25088200 Detail
0.010 Tumor Progression Moreover, we evaluated the relationship between MDSC recruitment, IL-6 levels, a... BeFree 25238263 Detail
<0.001 follicular adenoma NA BeFree Detail
<0.001 Sarcoma, Spindle Cell NA BeFree Detail
<0.001 HIV Encephalopathy NA BeFree Detail
<0.001 Pneumonia, Interstitial NA BeFree Detail
0.002 Lung Diseases, Interstitial NA GAD Detail
0.006 hyperandrogenism NA BeFree,GAD,LHGDN Detail
<0.001 Neuroectodermal Tumors NA BeFree Detail
0.005 Periodontal Attachment Loss NA GAD Detail
0.008 Lichen Planus, Oral NA BeFree,GAD,LHGDN Detail
<0.001 Diabetic Foot Genetic association of IL-6, TNF-α and SDF-1 polymorphisms with serum cytokine l... BeFree 25839939 Detail
0.002 Cytomegalovirus retinitis NA GAD Detail
<0.001 Ki-1+ Anaplastic Large Cell Lymphoma NA BeFree Detail
<0.001 exfoliation syndrome Cultured human Tenon's capsule fibroblasts were exposed to transforming growth f... BeFree 25275906 Detail
0.080 Tympanic Membrane Perforation NA RGD Detail
0.003 hepatoblastoma NA BeFree Detail
<0.001 Liposarcoma, Myxoid NA BeFree Detail
<0.001 Giant Cell Tumor of Bone NA BeFree Detail
<0.001 embryonal carcinoma NA BeFree Detail
<0.001 Adenocarcinoma, Clear Cell NA BeFree Detail
<0.001 Follicular thyroid carcinoma NA BeFree Detail
0.003 Carcinoma, Endometrioid NA BeFree,GAD Detail
0.127 cholangiocarcinoma There are reports that interleukin 6 (IL-6) may play an important role in the pa... BeFree,CTD_human,LHGDN 25041016 Detail
0.127 cholangiocarcinoma Interleukin 6 (IL-6)-mediated signal transducers and activators of transcription... BeFree,CTD_human,LHGDN 25344679 Detail
0.002 Cystadenocarcinoma, Serous NA GAD Detail
0.003 Cervical Intraepithelial Neoplasia NA BeFree,GAD Detail
<0.001 gliosarcoma NA BeFree Detail
<0.001 Strawberry nevus of skin NA BeFree Detail
0.002 Alphavirus Infections NA GAD Detail
0.005 Neuroendocrine Tumors NA BeFree,GAD,LHGDN Detail
<0.001 Adult Hodgkin Lymphoma NA BeFree Detail
<0.001 pediatric acute myeloblastic leukemia NA BeFree Detail
0.002 Lip and oral cavity carcinoma In conclusion, IL-6 -DNMT3b axis could be used to predict the prognosis of oral ... BeFree 24625449 Detail
<0.001 Hyperparathyroidism, Primary NA BeFree Detail
0.001 X-linked agammaglobulinemia NA BeFree Detail
<0.001 Adult type dermatomyositis NA BeFree Detail
0.005 Lytic lesion NA GAD Detail
<0.001 mesangial proliferative glomerulonephritis NA BeFree Detail
<0.001 Xanthoma tendinosum NA BeFree Detail
<0.001 Relative erythrocytosis NA BeFree Detail
<0.001 Melanosis coli NA BeFree Detail
<0.001 Effects of heat NA BeFree Detail
<0.001 Lesion of brain NA BeFree Detail
0.002 alpha 1-antitrypsin deficiency NA GAD Detail
<0.001 Nose symptoms NA BeFree Detail
0.002 Fibrillation NA BeFree Detail
<0.001 Memory impairment NA BeFree Detail
<0.001 Inflammatory pain NA BeFree Detail
<0.001 Rest pain NA BeFree Detail
<0.001 Acute urticaria NA BeFree Detail
<0.001 Neurologic Symptoms NA BeFree Detail
<0.001 Steroid withdrawal syndrome NA BeFree Detail
<0.001 Paroxysmal atrial fibrillation NA BeFree Detail
<0.001 proliferative glomerulonephritis NA BeFree Detail
<0.001 Vitritis NA BeFree Detail
<0.001 Renal Cell Dysplasia NA BeFree Detail
<0.001 Zinc deficiency NA BeFree Detail
0.007 pancreatic carcinoma Apoptosis, caspase activity, and cytokine production (IL-6, IL-10, TNF-β, and IF... BeFree 25725585 Detail
0.007 pancreatic carcinoma REG3A accelerates pancreatic cancer cell growth under IL-6-associated inflammato... BeFree 25779676 Detail
<0.001 Renal interstitial fibrosis NA BeFree Detail
<0.001 Colitis, Collagenous NA BeFree Detail
<0.001 fallopian tube carcinoma NA BeFree Detail
<0.001 Cancer of Nasopharynx NA BeFree Detail
0.001 Hereditary pancreatitis NA BeFree Detail
<0.001 Anaplastic thyroid carcinoma NA BeFree Detail
0.003 Papillary thyroid carcinoma NA BeFree,GAD Detail
0.001 Fibrosis, Liver Mutant MMP-9 and HGF gene transfer enhance resolution of CCl4-induced liver fibr... BeFree 25380300 Detail
0.001 Fibrosis, Liver HGF-overexpressing ADSCs ameliorated radiation- induced liver fibrosis through d... BeFree 25501583 Detail
0.120 Hypoalbuminemia NA CTD_human Detail
<0.001 Acute aortic dissection Furthermore, disruption of IL-6 effectively suppressed dilatation and rupture of... BeFree 25563839 Detail
0.120 Hepatitis, Autoimmune NA CTD_human Detail
<0.001 Unable to balance NA BeFree Detail
0.008 coronary stenosis NA BeFree,GAD,LHGDN Detail
<0.001 McCune-Albright syndrome NA BeFree Detail
0.003 Dyslipidemias Furthermore, the homeostasis model assessment of insulin resistance (HOMA-IR) in... BeFree,LHGDN 26264374 Detail
0.080 Erectile dysfunction NA RGD Detail
0.006 age related macular degeneration They provide rationale for the implication of IL-6 in AMD and open avenues towar... BeFree,GAD 25604058 Detail
0.002 Acute Lung Injury NA GAD Detail
0.005 Disease Progression NA GAD,LHGDN Detail
0.120 Ventricular Dysfunction, Left NA CTD_human Detail
<0.001 Bone Demineralization, Pathologic NA BeFree Detail
0.080 Hyperoxia NA RGD Detail
<0.001 Parasitemia NA BeFree Detail
0.001 Proliferative vitreoretinopathy NA BeFree Detail
0.009 Systemic Inflammatory Response Syndrome NA BeFree,GAD,LHGDN Detail
<0.001 Hantavirus Infections NA BeFree Detail
0.148 Sepsis Patients with postoperative sepsis were significantly (p = 0.002) more likely to... BeFree,GAD,LHGDN,RGD 24944154 Detail
0.148 Sepsis The protection of female hearts against the dysfunction associated with sepsis i... BeFree,GAD,LHGDN,RGD 24945834 Detail
0.148 Sepsis Plasma was analysed by ELISA for thrombin-antithrombin complex (TAT), D-dimer as... BeFree,GAD,LHGDN,RGD 25030319 Detail
0.148 Sepsis Analysis of 1163 miRNAs from PBMCs revealed that miR-182, miR-143, miR-145, miR-... BeFree,GAD,LHGDN,RGD 25265569 Detail
0.148 Sepsis In summary, this work provides the first in vivo evidence that administering BMM... BeFree,GAD,LHGDN,RGD 25337817 Detail
0.148 Sepsis Association between IL-6-174G/C polymorphism and the risk of sepsis and mortalit... BeFree,GAD,LHGDN,RGD 25734339 Detail
0.148 Sepsis The combination of markers (hs-CRP, PCT, and IL-6) is better than single markers... BeFree,GAD,LHGDN,RGD 25881528 Detail
<0.001 Carcinoma, Lewis Lung More intriguingly, by skewing macrophages polarization away from the M1- to a tu... BeFree 25313135 Detail
<0.001 Cardiovascular Abnormalities NA BeFree Detail
<0.001 fibrous dysplasia The use of bisphosphonates and IL-6 inhibitors has been explored to be useful in... BeFree 25530967 Detail
0.002 Myxoma of the Endocardium NA BeFree Detail
<0.001 Psoriasiform eczema NA BeFree Detail
<0.001 pemphigus foliaceus NA BeFree Detail
<0.001 Pemphigus and fogo selvagem NA BeFree Detail
<0.001 Psoriasis vulgaris NA BeFree Detail
<0.001 Epithelial hyperplasia of skin NA BeFree Detail
<0.001 Osteoarthritis of the hand Association of interleukin-6 gene polymorphisms with hand osteoarthritis and han... BeFree 25022967 Detail
<0.001 Interphalangeal osteoarthritis NA BeFree Detail
<0.001 Acute upper respiratory infection NA BeFree Detail
<0.001 Acute respiratory failure NA BeFree Detail
<0.001 lymphoid interstitial pneumonia NA BeFree Detail
<0.001 Greig cephalopolysyndactyly syndrome NA BeFree Detail
0.028 Chronic Periodontitis The association of IL-6 and IL-6R gene polymorphisms with chronic periodontitis ... BeFree,GAD,LHGDN 23433353 Detail
<0.001 Vesicular Stomatitis NA BeFree Detail
<0.001 Acute hepatitis NA BeFree Detail
<0.001 Hemodialysis-associated amyloidosis NA BeFree Detail
<0.001 Myeloma kidney NA BeFree Detail
<0.001 Endometrioma NA BeFree Detail
0.003 macular retinal edema NA BeFree,GAD Detail
<0.001 Severe myopia NA BeFree Detail
<0.001 Acute otitis media NA BeFree Detail
<0.001 chronic purulent otitis media Furthermore, proinflammatory cytokines TNF-α, IL-1β, IFN-γ, IL-6 were up-regulat... BeFree 24882571 Detail
0.005 Impaired glucose tolerance NA BeFree,GAD Detail
0.120 Lung Injury NA CTD_human Detail
<0.001 Coinfection NA BeFree Detail
<0.001 Pneumonia due to Escherichia coli NA BeFree Detail
<0.001 Viral myocarditis NA BeFree Detail
<0.001 Cytomegaloviral pneumonia NA BeFree Detail
0.002 Disease due to Parvoviridae NA GAD Detail
0.002 Respiratory syncytial virus bronchiolitis NA GAD Detail
<0.001 AIDS with Kaposi's sarcoma NA BeFree Detail
<0.001 Invasive Pulmonary Aspergillosis NA BeFree Detail
<0.001 Stage II Colon Cancer NA BeFree Detail
<0.001 extramedullary plasmacytoma NA BeFree Detail
<0.001 Disseminated neuroblastoma NA BeFree Detail
0.001 gastric adenocarcinoma NA BeFree Detail
<0.001 Prostate cancer recurrent NA BeFree Detail
0.001 Metastatic melanoma NA BeFree Detail
0.002 Cancer of Head and Neck NA BeFree Detail
<0.001 Liver and Intrahepatic Biliary Tract Carcinoma NA BeFree Detail
0.002 Squamous cell carcinoma of esophagus Moreover, we suggest inhibition of IL-6 as a potential strategy for the treatmen... BeFree 25238263 Detail
0.002 Squamous cell carcinoma of esophagus The protein levels of STAT3, phosphorylated STAT3, VEGF, NF-κB p65, phosphorylat... BeFree 25405520 Detail
0.002 Squamous cell carcinoma of esophagus The role of HGF/MET and FGF/FGFR in fibroblast-derived growth stimulation and la... BeFree 25884729 Detail
<0.001 Adenocarcinoma Of Esophagus NA BeFree Detail
<0.001 cervical squamous cell carcinoma NA BeFree Detail
<0.001 Conventional (Clear Cell) Renal Cell Carcinoma NA BeFree Detail
0.002 Solid tumour NA BeFree Detail
<0.001 stage, ovarian epithelial cancer Taken together, our results offer a preclinical rationale to combine anti-IL6 an... BeFree 25670170 Detail
<0.001 stage, prostate cancer NA BeFree Detail
<0.001 Squamous cell carcinoma of tonsil NA BeFree Detail
<0.001 Adenocarcinoma of pancreas NA BeFree Detail
<0.001 intraocular lymphoma NA BeFree Detail
0.003 interstitial cystitis NA BeFree,LHGDN Detail
0.002 Very Low Birth Weight NA BeFree Detail
<0.001 Infant, Very Low Birth Weight NA BeFree Detail
<0.001 Disease caused by Shigella dysenteriae NA BeFree Detail
0.010 cervix carcinoma Stratification analysis and case-control study of relationships between interleu... BeFree,GAD 25227842 Detail
<0.001 Obesity, Abdominal NA BeFree Detail
<0.001 Dryness of eye NA BeFree Detail
0.003 Restenosis The aim of the present study was to establish the role of IL-6 and TGF-β1 gene p... BeFree,GAD 25449332 Detail
<0.001 Healing ulcer NA BeFree Detail
0.002 Senile Plaques NA BeFree Detail
<0.001 Tumor necrosis NA BeFree Detail
0.003 Infarction, Lacunar NA BeFree,GAD Detail
<0.001 inflammatory myofibroblastic tumor NA BeFree Detail
<0.001 Arteriovenous hemangioma NA BeFree Detail
<0.001 Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse NA BeFree Detail
<0.001 Adenocarcinoma of colon NA BeFree Detail
0.002 Common Migraine NA GAD Detail
0.002 Impaired cognition NA BeFree Detail
<0.001 Mixed anxiety and depressive disorder NA BeFree Detail
0.005 Thyroid associated opthalmopathies IEGs, IL-1B, and IL-6 were overexpressed in smokers with severe active GO compar... BeFree,GAD 25135760 Detail
0.005 Thyroid associated opthalmopathies We also examined mucosal expression of IL-6, which stimulates excess GAG synthes... BeFree,GAD 25198673 Detail
<0.001 Seasonal allergic conjunctivitis NA BeFree Detail
<0.001 Epiretinal Membrane NA BeFree Detail
<0.001 Simple pneumoconiosis NA BeFree Detail
<0.001 Complicated pneumoconiosis NA BeFree Detail
0.001 Stable angina NA BeFree Detail
<0.001 Q fever endocarditis NA BeFree Detail
<0.001 Dissection of aorta NA BeFree Detail
<0.001 Deep vein thrombosis of lower limb NA BeFree Detail
0.001 Chronic liver disease NA BeFree Detail
<0.001 endometriosis of uterus HGF may be involved in gland invagination deep into the myometrium by inducing E... BeFree 25505196 Detail
0.007 Complications of Diabetes Mellitus NA GAD Detail
<0.001 Idiopathic hirsutism Similarly, patients with IH exhibit significantly lower IL6 mRNA expression and ... BeFree 26194504 Detail
0.002 Malonic aciduria As a consequence, vIL-6 can activate many cell types that are unresponsive to ce... BeFree 25243371 Detail
<0.001 Erythema nodosum leprosum NA BeFree Detail
<0.001 African Burkitt's lymphoma NA BeFree Detail
0.120 HIV Wasting Syndrome NA CTD_human Detail
<0.001 Absence of pain sensation NA BeFree Detail
<0.001 Malignant neoplasm of liver NA BeFree Detail
<0.001 malignant mesothelioma NA BeFree Detail
0.003 Growth Hormone-Secreting Pituitary Adenoma NA LHGDN Detail
0.007 Malignant neoplasm of pancreas Apoptosis, caspase activity, and cytokine production (IL-6, IL-10, TNF-β, and IF... BeFree 25725585 Detail
0.007 Malignant neoplasm of pancreas REG3A accelerates pancreatic cancer cell growth under IL-6-associated inflammato... BeFree 25779676 Detail
<0.001 Nonorganic psychosis NA BeFree Detail
<0.001 Cervical intraepithelial neoplasia grade 2 NA BeFree Detail
<0.001 Early gastric cancer NA BeFree Detail
<0.001 Ischemic cardiomyopathy NA BeFree Detail
<0.001 prediabetes syndrome NA BeFree Detail
0.002 Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site miR-155 and miR-146b negatively regulates IL6 in Helicobacter pylori (cagA+) inf... BeFree 25753878 Detail
0.002 Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site Interestingly, release of IL-6 and IL-8 after RSV, but not HRV, infection was sy... BeFree 25411435 Detail
0.003 Malignant neoplasm of vulva NA BeFree,GAD Detail
0.051 Malignant neoplasm of prostate Regulation of SOD2 and β-arrestin1 by interleukin-6 contributes to the increase ... BeFree,GAD 24939178 Detail
0.051 Malignant neoplasm of prostate Prostate cancer is frequently associated with elevated levels of interleukin-6 (... BeFree,GAD 25243457 Detail
0.051 Malignant neoplasm of prostate IL-6 can convert non-ALDH(high) cells to ALDH(high) cells in prostate cancer cel... BeFree,GAD 25261365 Detail
0.051 Malignant neoplasm of prostate Analysis of inflammatory genes in the patient tissues revealed that IL-6 express... BeFree,GAD 25305352 Detail
0.051 Malignant neoplasm of prostate Early Growth Response 3 regulates genes of inflammation and directly activates I... BeFree,GAD 25633035 Detail
0.051 Malignant neoplasm of prostate Cellular Vaccines Modified with Hyper IL6 or Hyper IL11 Combined with Docetaxel ... BeFree,GAD 26026087 Detail
0.005 gingival overgrowth NA GAD Detail
0.005 Hematologic Neoplasms NA BeFree,GAD Detail
0.085 Endotoxemia NA GAD,RGD Detail
<0.001 Plasma cell inflammation NA BeFree Detail
<0.001 Hereditary hemochromatosis NA BeFree Detail
0.007 Atopy NA GAD Detail
0.002 multiple system atrophy NA GAD Detail
<0.001 thrombophilia NA BeFree Detail
0.006 Immune thrombocytopenic purpura NA BeFree,GAD,LHGDN Detail
0.001 Hereditary gingival fibromatosis NA BeFree Detail
0.002 Non-alcoholic Fatty Liver Disease In addition, decreased numbers of CD4+ and CD8+ T lymphocytes and increased leve... BeFree 25644696 Detail
0.001 Chronic Kidney Insufficiency NA BeFree Detail
<0.001 Chronic rejection of renal transplant NA BeFree Detail
<0.001 Infective vaginitis NA BeFree Detail
<0.001 Osteoarthritis of distal interphalangeal joint Association of interleukin-6 gene polymorphisms with hand osteoarthritis and han... BeFree 25022967 Detail
0.004 Osteoarthritis, Knee Association of interleukin-6 promoter polymorphism with knee osteoarthritis: a m... BeFree,GAD 24985590 Detail
0.004 lupus erythematosus NA BeFree,GAD Detail
0.001 Muscle damage NA BeFree Detail
<0.001 Congenital Myotonic Dystrophy NA BeFree Detail
0.001 Adolescent idiopathic scoliosis NA BeFree Detail
0.002 Fever symptoms (finding) NA GAD Detail
<0.001 Spastic Quadriplegia NA BeFree Detail
<0.001 Ichthyosis bullosa of Siemens NA BeFree Detail
<0.001 Fatigue - symptom NA BeFree Detail
<0.001 neuropathy NA BeFree Detail
<0.001 urolithiasis NA BeFree Detail
<0.001 Sepsis of the newborn NA BeFree Detail
<0.001 Plasma cell tumor, malignant NA BeFree Detail
0.001 endometrial carcinoma Overall, our results provide a preclinical rationale to target IL6 or its effect... BeFree 26130650 Detail
<0.001 Human anaplasmosis due to Anaplasma phagocytophilum NA BeFree Detail
0.001 Secondary malignant neoplasm of liver NA BeFree Detail
0.009 dementia NA BeFree,GAD Detail
0.004 Overweight We evaluated the plasma fatty acid (FA) response to a DHA-rich supplement in APO... BeFree 26085515 Detail
0.002 body mass NA GAD Detail
0.002 Necrotizing Enterocolitis NA BeFree Detail
<0.001 acute pyelonephritis NA BeFree Detail
0.015 Sleep Apnea, Obstructive NA BeFree,GAD,LHGDN Detail
0.001 Recurrent tumor The expression of pluripotency-related genes is associated with early tumor recu... BeFree 25564572 Detail
<0.001 Gallstone pancreatitis NA BeFree Detail
<0.001 Fibrosis of urinary bladder NA BeFree Detail
0.144 Metabolic syndrome X Association of IL-6 polymorphism -174G/C and metabolic syndrome in hypertensive ... BeFree,CTD_human,GAD,LHGDN 25815341 Detail
0.124 Neurodegenerative Disorders NA BeFree,CTD_human,LHGDN Detail
0.011 Hepatitis B, Chronic Interleukin-6 upregulates Th17 response via mTOR/STAT3 pathway in acute-on-chron... BeFree,GAD,LHGDN 24366287 Detail
0.016 Hepatitis C, Chronic Characterisation of the cytokine milieu associated with the up-regulation of IL-... BeFree,GAD,LHGDN 24461080 Detail
0.016 Hepatitis C, Chronic The aim of this study was to assess whether two-years treatment with Pirfenidone... BeFree,GAD,LHGDN 25064094 Detail
0.016 Hepatitis C, Chronic We investigated the association between hepatitis C virus (HCV) genotypes and ho... BeFree,GAD,LHGDN 25193024 Detail
<0.001 Schnitzler syndrome NA BeFree Detail
0.005 Mood Disorders NA BeFree,GAD Detail
<0.001 Mixed cryoglobulinemia NA BeFree Detail
0.013 Malignant neoplasm of esophagus NA BeFree,GAD Detail
<0.001 Subacromial bursitis NA BeFree Detail
<0.001 Thyroid carcinoma NA BeFree Detail
<0.001 Oropharyngeal disorders NA BeFree Detail
<0.001 Squamous cell carcinoma of skin NA BeFree Detail
0.002 Malignant glioma NA BeFree Detail
<0.001 IgG myeloma NA BeFree Detail
<0.001 primary sclerosing cholangitis NA BeFree Detail
0.003 Carotid Atherosclerosis NA BeFree,GAD Detail
<0.001 Chronic idiopathic urticaria Interleukin-6 and tumor necrosis factor-alpha gene polymorphisms in chronic idio... BeFree 24051251 Detail
<0.001 Chronic idiopathic urticaria Role of IFN-γ and IL-6 cytokines and their association in determining susceptibi... BeFree 25409241 Detail
<0.001 Minor oral aphthous ulceration NA BeFree Detail
0.003 Osteosarcoma of bone NA BeFree Detail
<0.001 Intraocular pressure disorder NA BeFree Detail
<0.001 Aqueous Humor Disorders NA BeFree Detail
0.022 Carcinogenesis Chronic inflammation is an established risk factor for the onset of cancer, and ... BeFree 24531714 Detail
0.022 Carcinogenesis Collectively, our data reveal that a key molecular mechanism by which NNK promot... BeFree 24727895 Detail
0.022 Carcinogenesis Overall, the present data suggested that ITGB1 upregulation was involved in the ... BeFree 24931361 Detail
0.022 Carcinogenesis Co-targeting c-Met and COX-2 leads to enhanced inhibition of lung tumorigenesis ... BeFree 25057941 Detail
0.022 Carcinogenesis Although IL-17RA signaling also controls the production of IL-6, this mechanism ... BeFree 25526314 Detail
0.022 Carcinogenesis IL-6 originated from breast cancer tissue-derived mesenchymal stromal cells may ... BeFree 25697898 Detail
0.022 Carcinogenesis PPAR-δ overexpression in colonic epithelial cells promoted CAC tumorigenesis in ... BeFree 25713055 Detail
0.022 Carcinogenesis The inhibition of p38 MAPK in PDXs results in downregulation of the IL-6/STAT3 s... BeFree 25890501 Detail
0.022 Carcinogenesis The interleukin-6 (IL-6)/Janus kinase (JAK)/signal transducer and activator of t... BeFree 26061266 Detail
0.022 Carcinogenesis Thus, IL-6 plays pivotal roles in both paraneoplastic syndrome and the oncogenes... BeFree 26165403 Detail
<0.001 hyperhomocysteinemia NA BeFree Detail
<0.001 Tumor Initiation Activation of the MET/HGF pathway is common in human cancer and is thought to pr... BeFree 25504634 Detail
<0.001 chronic interstitial cystitis NA BeFree Detail
0.030 prostate carcinoma Regulation of SOD2 and β-arrestin1 by interleukin-6 contributes to the increase ... BeFree 24939178 Detail
0.030 prostate carcinoma Prostate cancer is frequently associated with elevated levels of interleukin-6 (... BeFree 25243457 Detail
0.030 prostate carcinoma IL-6 can convert non-ALDH(high) cells to ALDH(high) cells in prostate cancer cel... BeFree 25261365 Detail
0.030 prostate carcinoma Analysis of inflammatory genes in the patient tissues revealed that IL-6 express... BeFree 25305352 Detail
0.030 prostate carcinoma Early Growth Response 3 regulates genes of inflammation and directly activates I... BeFree 25633035 Detail
0.030 prostate carcinoma Cellular Vaccines Modified with Hyper IL6 or Hyper IL11 Combined with Docetaxel ... BeFree 26026087 Detail
0.002 Choroidal Neovascularization NA GAD Detail
0.007 Hashimoto Disease The allele C in IL6-174 G/C is also associated with Hashimoto's thyroiditis, how... BeFree,GAD,LHGDN 25127106 Detail
<0.001 Gastro-esophageal reflux disease with esophagitis NA BeFree Detail
0.005 Epithelial ovarian cancer NA BeFree,GAD Detail
<0.001 Progressive Neoplastic Disease NA BeFree Detail
<0.001 Terminal illness NA BeFree Detail
<0.001 Tuberculosis, extrapulmonary We also performed the analyses by sample types in IL-6 -174 C/G polymorphism, an... BeFree 26169021 Detail
<0.001 inflammatory joint disease NA BeFree Detail
<0.001 Malignant neoplasm of gastrointestinal tract NA BeFree Detail
<0.001 CNS metastases New cytokine inhibitors targeting IL-1 and IL-6 appear to be effective especiall... BeFree 26487500 Detail
0.002 Secondary malignant neoplasm of lymph node NA BeFree Detail
<0.001 heavy drinking NA BeFree Detail
0.002 Pregnancy loss NA GAD Detail
0.002 Community acquired pneumonia The FAIM3:PLAC8 ratio outperformed plasma procalcitonin and IL-8 and IL-6 in dis... BeFree 26121490 Detail
<0.001 Infection of ear NA BeFree Detail
0.007 colon carcinoma Genomic instability causes HGF gene activation in colon cancer cells, promoting ... BeFree 25244939 Detail
0.007 colon carcinoma Furthermore, cycling hypoxia-specific inflammatory phenotype, characterized by a... BeFree 25622900 Detail
0.007 colon carcinoma The effectiveness of an anti-human IL-6 receptor monoclonal antibody combined wi... BeFree 25625841 Detail
0.007 colon carcinoma 15-LOX-1 down-regulation was associated with IL-6 up-regulation in human colon c... BeFree 25713055 Detail
0.007 colon carcinoma High interleukin-6 mRNA expression is a predictor of relapse in colon cancer. BeFree 25862884 Detail
0.007 colon carcinoma Interleukin-1 Receptor Type 2 Acts with c-Fos to Enhance the Expression of Inter... BeFree 26209639 Detail
0.012 stomach carcinoma Clinical impact of the HGF/MET pathway activation in patients with advanced gast... BeFree 24663077 Detail
0.012 stomach carcinoma Additionally, signal transducer and activator of transcription 3 (STAT3) was als... BeFree 25234193 Detail
0.012 stomach carcinoma IL-33 promotes gastric cancer cell invasion and migration by stimulating the sec... BeFree 25655003 Detail
0.005 Carcinoma of bladder Interleukin-12 and interleukin-6 gene polymorphisms and risk of bladder cancer i... BeFree 25292079 Detail
0.002 skin carcinoma NA GAD Detail
<0.001 airway disease IL-6 trans-signaling increases expression of airways disease genes in airway smo... BeFree 26001777 Detail
0.003 Central neuroblastoma NA BeFree Detail
<0.001 Dyssomnias NA BeFree Detail
<0.001 Acute anterior uveitis NA BeFree Detail
<0.001 Thalassemia trait NA BeFree Detail
<0.001 acne The interleukin-6 and interleukin-1A gene promoter polymorphism is associated wi... BeFree 25432444 Detail
<0.001 Dissecting aneurysm of the thoracic aorta NA BeFree Detail
<0.001 Microalbuminuria While IL6, CCL2 and CCR5-mRNA, and CD68 were overexpressed in the tubulointersti... BeFree 24786705 Detail
<0.001 Middle Cerebral Artery Occlusion In conclusion, the results suggest that CXCL10 and IL-6 have important roles in ... BeFree 25333814 Detail
0.120 Infarction, Middle Cerebral Artery NA CTD_human Detail
<0.001 hyperuricemia The synthesis of IL6 and IL8 proteins induced by PRP is decreased significantly ... BeFree 25276832 Detail
0.003 Malignant neoplasm of kidney Association between the interleukin-6 gene polymorphisms and renal cancer risk. BeFree,GAD 25766682 Detail
<0.001 carotid disease NA BeFree Detail
<0.001 Hypereosinophilia NA BeFree Detail
<0.001 infertility tubal factor NA BeFree Detail
<0.001 End Stage Liver Disease NA BeFree Detail
<0.001 Chronic lung disease NA BeFree Detail
<0.001 Otitis media recurrent NA BeFree Detail
<0.001 Scleroderma, Limited NA BeFree Detail
<0.001 biliary tract cancer NA BeFree Detail
<0.001 Cystic Periventricular Leukomalacia NA BeFree Detail
<0.001 Memory Loss NA BeFree Detail
<0.001 Central Core Myopathy (disorder) NA BeFree Detail
0.005 brain infarction NA BeFree,GAD,LHGDN Detail
<0.001 Acute Cerebrovascular Accidents NA BeFree Detail
<0.001 Multiple Sclerosis, Relapsing-Remitting Persistent production of IL-6, in turn, contributes to T cell expansion and the ... BeFree 25794663 Detail
<0.001 Myasthenia Gravis, Autoimmune, Experimental NA BeFree Detail
<0.001 Hypoxic-Ischemic Encephalopathy NA BeFree Detail
0.005 Hypoxia-Ischemia, Brain NA GAD,LHGDN Detail
<0.001 Lewy Body Disease NA BeFree Detail
<0.001 malignant pleural mesothelioma NA BeFree Detail
0.004 thrombocytosis NA BeFree,LHGDN Detail
<0.001 Myeloma, malignant NA BeFree Detail
<0.001 Uterine carcinoma NA BeFree Detail
<0.001 Subfertility, Male NA BeFree Detail
<0.001 neurological disability Furthermore, the production of IL-17 and IL-6 by MS-derived T cells was directly... BeFree 24882215 Detail
0.002 Helicobacter pylori infection NA BeFree Detail
0.002 Sleep Disorders NA GAD Detail
0.001 Oestrogen deficiency NA BeFree Detail
<0.001 Invasive breast carcinoma Mammospheres (MS) from node invasive breast carcinoma tissues express IL-6 mRNA ... BeFree 25881039 Detail
<0.001 Cognitive deterioration NA BeFree Detail
<0.001 Bacterial keratitis IL-8 > IL-6 in patients with bacterial keratitis; IL-8 > IL-6 > IL-1β and increa... BeFree 25741769 Detail
0.003 Neonatal infection PCT had greater diagnostic value than did hs-CRP and IL-6, while IL-6 was better... BeFree,GAD 25881528 Detail
<0.001 Fat redistribution NA BeFree Detail
0.002 Endothelial dysfunction Neutralization of tumor necrosis factor-α and IL-6 (both downstream of IL-17A) r... BeFree 25341795 Detail
0.002 Endothelial dysfunction HGF/Met has beneficial effects against myocardial infarction and endothelial dys... BeFree 26561593 Detail
0.002 Acute GVH disease Risk model incorporating donor IL6 and IFNG genotype and gastrointestinal GVHD c... BeFree 25774595 Detail
0.003 Thrombocytopenic purpura NA LHGDN Detail
0.122 Drug-Induced Liver Injury NA CTD_human,GAD Detail
<0.001 lupus erythematodes NA BeFree Detail
0.001 Chronic graft-versus-host disease NA BeFree Detail
<0.001 Psychotic symptom NA BeFree Detail
<0.001 social stress NA BeFree Detail
0.121 Cardiomyopathies NA BeFree,CTD_human Detail
<0.001 pathergy NA BeFree Detail
<0.001 Growth failure NA BeFree Detail
<0.001 Hereditary Papillary Renal Carcinoma NA BeFree Detail
0.001 Stromal Neoplasm These results suggest that SPINT2 is associated with tumor-suppressive functions... BeFree 25910030 Detail
0.002 Cerebral Ischemia NA BeFree Detail
0.129 ovarian neoplasm NA BeFree,CTD_human,GAD,LHGDN Detail
<0.001 Engraftment syndrome NA BeFree Detail
0.002 Microsatellite Instability NA GAD Detail
0.003 autoimmune thyroiditis NA BeFree,GAD Detail
0.002 Insulin Sensitivity NA GAD Detail
<0.001 Renal ischaemia NA BeFree Detail
0.002 Metastatic Prostate Carcinoma NA BeFree Detail
<0.001 cholecystolithiasis NA BeFree Detail
<0.001 Vascular inflammations NA BeFree Detail
0.003 Primary Graft Dysfunction NA LHGDN Detail
0.021 Acute coronary syndrome NA BeFree,GAD,LHGDN Detail
<0.001 Primary infection NOS NA BeFree Detail
<0.001 Carcinoma of peritoneum NA BeFree Detail
<0.001 Colorectal cancer metastatic NA BeFree Detail
<0.001 Spondylarthritis However, Dkk-1 levels showed an inverse correlation with IL-6 levels in both SpA... BeFree 25941031 Detail
0.002 Spondylarthropathies NA GAD Detail
0.002 Papillomavirus Infections NA GAD Detail
<0.001 Arthritis, Collagen-Induced NA BeFree Detail
0.121 Arthritis, Experimental NA BeFree,CTD_human Detail
<0.001 Drug Resistant Epilepsy NA BeFree Detail
<0.001 Macrophage Activation Syndrome While this therapy has caused toxicities, including cytokine release syndrome an... BeFree 25455270 Detail
<0.001 Macrophage Activation Syndrome Inhibition of natural killer cell cytotoxicity by interleukin-6: implications fo... BeFree 26251193 Detail
<0.001 Intrauterine infection NA BeFree Detail
<0.001 Gastrooesophageal cancer NA BeFree Detail
<0.001 Stage 4S neuroblastoma NA BeFree Detail
<0.001 Heart Failure, Diastolic NA BeFree Detail
0.005 HIV-Associated Lipodystrophy Syndrome NA GAD,LHGDN Detail
0.013 Malignant neoplasm of ovary HGF/c-Met axis drives cancer aggressiveness in the neo-adjuvant setting of ovari... BeFree,GAD 24952592 Detail
0.013 Malignant neoplasm of ovary In addition, we found that the expression level of IL6 was correlated with activ... BeFree,GAD 25319391 Detail
0.013 Malignant neoplasm of ovary Ovarian cancer ascites were collected from patients, and we found that primary C... BeFree,GAD 25658637 Detail
0.013 Malignant neoplasm of ovary Adaptive Upregulation of EGFR Limits Attenuation of Tumor Growth by Neutralizing... BeFree,GAD 25670170 Detail
0.013 Malignant neoplasm of ovary HGF expression in four ovarian cancer cell lines was evaluated by using semi-qua... BeFree,GAD 26335595 Detail
0.005 Squamous cell carcinoma of the head and neck Overall, the IL1α/IL1R/MYD88/IL6 pathway may be responsible for the reduced anti... BeFree 25712126 Detail
0.002 severe acute respiratory syndrome NA GAD Detail
<0.001 Child Malnutrition IL-6 572 C/G, 190 C/T, and 174 G/C gene polymorphisms in children's malnutrition... BeFree 25023587 Detail
<0.001 Myxoid cyst NA BeFree Detail
<0.001 Aortic valve disorder NA BeFree Detail
<0.001 Morphologically altered structure NA BeFree Detail
0.005 sarcoma NA BeFree Detail
<0.001 Lymphocytic infiltration Additionally, IL-6 polymorphism could influence lymphocytic infiltration of sali... BeFree 24393164 Detail
<0.001 Fungal keratitis IL-8 > IL-6 in patients with bacterial keratitis; IL-8 > IL-6 > IL-1β and increa... BeFree 25741769 Detail
0.002 attention deficit hyperactivity disorder NA GAD Detail
<0.001 Histiocytoma, Angiomatoid Fibrous Thus, IL-6 plays pivotal roles in both paraneoplastic syndrome and the oncogenes... BeFree 26165403 Detail
0.002 major depressive disorder NA BeFree Detail
0.002 Blood pressure finding NA GAD Detail
0.002 Systemic arterial pressure NA GAD Detail
<0.001 First myocardial infarction NA BeFree Detail
<0.001 Acral pseudolymphomatous angiokeratoma of children (APACHE) NA BeFree Detail
<0.001 TNF receptor-associated periodic fever syndrome (TRAPS) NA BeFree Detail
<0.001 Funisitis (disorder) NA BeFree Detail
<0.001 Left ventricular systolic dysfunction NA BeFree Detail
<0.001 Degenerative disorder NA BeFree Detail
0.002 Inflammatory disorder Following disease induction, daily systemic administration of human recombinant ... BeFree 25619792 Detail
0.002 Inflammatory disorder IL-6 is a major causative factor of inflammatory disease. BeFree 26026064 Detail
0.002 Inflammatory disorder Whole-Body In Vivo Monitoring of Inflammatory Diseases Exploiting Human Interleu... BeFree 26283726 Detail
0.002 Inflammatory disorder The present study supports that EB might be considered a systemic inflammatory d... BeFree 26496255 Detail
0.001 Chronic inflammatory disorder NA BeFree Detail
0.003 Primary Effusion Lymphoma Targeting VEGF and interleukin-6 for controlling malignant effusion of primary e... BeFree 25304617 Detail
<0.001 Precursor B-cell lymphoblastic leukemia NA BeFree Detail
<0.001 Pancreatic intraepithelial neoplasia NA BeFree Detail
<0.001 Cardiovascular morbidity NA BeFree Detail
<0.001 Eosinophilic disorder By contrast, levels of the inflammatory cytokines IL-17A and IL-6 were significa... BeFree 25363529 Detail
<0.001 Peripheral arterial occlusive disease NA BeFree Detail
0.002 Liver regeneration disorder In the in vitro experiments, LPS preconditioning of ASCs enhanced the mRNA expre... BeFree 25890074 Detail
<0.001 Squamous cell carcinoma of pharynx NA BeFree Detail
<0.001 Nephrogenic rest NA BeFree Detail
0.001 Hormone refractory prostate cancer Further preclinical study might reveal the potential use of zerumbone as a chemo... BeFree 25243457 Detail
<0.001 Adenocarcinoma of the gastroesophageal junction In particular, strong preclinical evidence for the aberrant activation of the HG... BeFree 26049023 Detail
<0.001 Classical Hodgkin's Lymphoma NA BeFree Detail
<0.001 Invasive Carcinoma NA BeFree Detail
<0.001 mesenchymal cell neoplasm IL-6 expression was significantly higher in mesenchymal tumors, and knockdown of... BeFree 24833103 Detail
<0.001 Mucinous Neoplasm Expression of NF-κB appears to be related to the level of the neoplastic differe... BeFree 25007180 Detail
0.001 Multi-centric Castleman's Disease NA BeFree Detail
<0.001 Epithelioma NA BeFree Detail
0.001 renal carcinoma Association between the interleukin-6 gene polymorphisms and renal cancer risk. BeFree 25766682 Detail
0.005 Systemic onset juvenile chronic arthritis PBMCs harvested from patients with systemic JIA during periods of active or inac... BeFree,GAD 26251193 Detail
<0.001 Increased susceptibility to fractures NA BeFree Detail
<0.001 Cardiac fibrosis NA BeFree Detail
<0.001 Myocardial necrosis NA BeFree Detail
<0.001 Avascular necrosis of the capital femoral epiphysis Association of gene variants in TLR4 and IL-6 genes with Perthes disease. BeFree 25233690 Detail
<0.001 Cardiomyopathy, Familial Idiopathic The tumor necrosis factor-α -238G/A and IL-6 -572G/C gene polymorphisms and the ... BeFree 25274950 Detail
<0.001 Cardiomyopathy, Familial Idiopathic Polymorphisms of tumor necrosis factor-alpha and interleukin-6 gene and C-reacti... BeFree 25827698 Detail
<0.001 Diabetic foot ulcer Genetic association of IL-6, TNF-α and SDF-1 polymorphisms with serum cytokine l... BeFree 25839939 Detail
0.154 Mammary Neoplasms Immunofluorescent staining of human primary and secondary breast tumours showed ... BeFree,CTD_human,LHGDN 25481644 Detail
0.154 Mammary Neoplasms Interleukin-6 and pro inflammatory status in the breast tumor microenvironment. BeFree,CTD_human,LHGDN 25881039 Detail
0.003 Human T-cell lymphotropic virus 1 infection NA BeFree,GAD Detail
<0.001 Hepatocarcinogenesis Cirp deficiency reduced production of interleukin-1β and interleukin-6 in Kupffe... BeFree 25611373 Detail
<0.001 Cancer Cell Growth Based on these findings and a drug screening study, we demonstrated that combine... BeFree 24726897 Detail
<0.001 Cancer Cell Growth Senescent cells secrete various growth factors and cytokines, such as IL-6, that... BeFree 25512378 Detail
<0.001 ovarian clear cell adenocarcinoma NA BeFree Detail
0.001 Tumor Angiogenesis NA BeFree Detail
0.002 Tumor Promotion NA BeFree Detail
<0.001 Xenograft Model In transformed cells, enforced expression of SOCS3 or interfering with IL6 pathw... BeFree 24531711 Detail
0.036 colorectal cancer The Th17 cell differentiation simulators IL-1β and IL-6 were also shown in an in... BeFree,GAD 24859972 Detail
0.036 colorectal cancer Bradykinin stimulates IL-6 production and cell invasion in colorectal cancer cel... BeFree,GAD 25109623 Detail
0.036 colorectal cancer Th17-type cytokines, IL-6 and TNF-α synergistically activate STAT3 and NF-kB to ... BeFree,GAD 25174402 Detail
0.036 colorectal cancer Upregulation of TLRs and IL-6 as a marker in human colorectal cancer. BeFree,GAD 25547486 Detail
0.036 colorectal cancer Interleukin-6 (IL-6) promotes cellular proliferation and drug resistance in colo... BeFree,GAD 25625841 Detail
0.036 colorectal cancer Identification of 15-LOX-1 suppression of PPAR-δ to inhibit IL-6/STAT3 signaling... BeFree,GAD 25713055 Detail
0.036 colorectal cancer Differential role of MACC1 expression and its regulation of the HGF/c‑Met pathwa... BeFree,GAD 25738887 Detail
0.036 colorectal cancer In this study, we demonstrate that fos-related antigen-1 (Fra-1) plays a critica... BeFree,GAD 25750173 Detail
0.002 Sjogren's syndrome NA GAD Detail
<0.001 Ductal Breast Carcinoma NA BeFree Detail
<0.001 Neoplasms, Intracranial NA BeFree Detail
<0.001 fertility disorders NA BeFree Detail
<0.001 Pneumocystis jiroveci pneumonia NA BeFree Detail
<0.001 Geographic Atrophy NA BeFree Detail
<0.001 infective endocarditis In this study, 14 single nucleotide variants (SNVs) in genes coding for interleu... BeFree 25299518 Detail
0.002 Non-Malignant Ascites Adverse Event NA BeFree Detail
0.004 Chronic Kidney Diseases Interleukin-6 (IL-6) is one of the inflammation biomarkers with highest predicti... BeFree 25376195 Detail
0.004 Chronic Kidney Diseases Association of IL-6 and a functional polymorphism in the IL-6 gene with cardiova... BeFree 25492254 Detail
0.003 Renal Insufficiency NA BeFree,GAD Detail
<0.001 Immune Reconstitution Inflammatory Syndrome NA BeFree Detail
0.001 Glioblastoma multiforme NA BeFree Detail
0.002 Cirrhosis We prospectively assessed the influence of 6 single nucleotide polymorphisms (SN... BeFree 24751829 Detail
0.002 Macular dystrophy, corneal type 1 As a consequence, vIL-6 can activate many cell types that are unresponsive to ce... BeFree 25243371 Detail
<0.001 Disorder characterized by eosinophilia By contrast, levels of the inflammatory cytokines IL-17A and IL-6 were significa... BeFree 25363529 Detail
<0.001 androgen independent prostate cancer NA BeFree Detail
<0.001 tumor vasculature NA BeFree Detail
0.002 Benign Prostatic Hyperplasia NA BeFree Detail
<0.001 Nephrotic Syndrome, Minimal Change NA BeFree Detail
0.002 Peripheral Arterial Diseases Expression of both IL-6 (P = .024) and CD36 (P = .018) was greater in PAD subjec... BeFree 25095746 Detail
0.002 Peripheral Arterial Diseases Thus administration of HGF or HGF mimetics may represent a promising therapeutic... BeFree 26561593 Detail
0.001 Non-Neoplastic Disorder Mammospheres (MS) from node invasive breast carcinoma tissues express IL-6 mRNA ... BeFree 25881039 Detail
0.001 Severe Sepsis NA BeFree Detail
<0.001 Meningioma, benign, no ICD-O subtype NA BeFree Detail
0.007 Idiopathic Pulmonary Fibrosis NA BeFree,GAD,LHGDN Detail
<0.001 Chromosome 11p11.2 Deletion Syndrome NA BeFree Detail
<0.001 IMMUNE SUPPRESSION NA BeFree Detail
<0.001 Mammographic Density NA BeFree Detail
<0.001 VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding) NA BeFree Detail
<0.001 peeling skin syndrome NA BeFree Detail
<0.001 Hypotrichosis simplex NA BeFree Detail
<0.001 Asthma and nasal polyps Age-related increased prevalence of asthma and nasal polyps in chronic rhinosinu... BeFree 26266960 Detail
0.240 Rheumatoid Arthritis, Systemic Juvenile NA BeFree,CTD_human,ORPHANET Detail
0.005 Venous thromboembolism NA GAD Detail
<0.001 Amyotrophic Lateral Sclerosis, Sporadic NA BeFree Detail
0.001 uterine corpus cancer Overall, our results provide a preclinical rationale to target IL6 or its effect... BeFree 26130650 Detail
0.067 coronary artery disease IL-6 gene promoter polymorphisms and risk of coronary artery disease in a Chines... BeFree,GAD,LHGDN 25299085 Detail
0.067 coronary artery disease Role of IL-6 polymorphism on the development of cardiovascular events and corona... BeFree,GAD,LHGDN 25867411 Detail
0.005 temporal arteritis NA GAD Detail
<0.001 Myocardial Failure NA BeFree Detail
0.004 plasma cell neoplasm NA BeFree,LHGDN Detail
0.005 Precursor Cell Lymphoblastic Leukemia Lymphoma NA BeFree,GAD Detail
0.002 Proteinuria Adverse Event NA GAD Detail
<0.001 aromatase excess syndrome NA BeFree Detail
0.002 Cicatrix NA GAD Detail
<0.001 Urothelial Carcinoma Furthermore, our results suggested that urinary IL-8, IL-6 and CK-18 may benefit... BeFree 25640370 Detail
0.167 liver carcinoma RMP promotes venous metastases of hepatocellular carcinoma through promoting IL-... BeFree,CTD_human,GAD,LHGDN 24704835 Detail
0.167 liver carcinoma TNFα (G-238A, C-863A, G-308A), IL6 (C-174G), and IL1β (C-31T, C-511T) SNPs were ... BeFree,CTD_human,GAD,LHGDN 24751829 Detail
0.167 liver carcinoma Twist-1 and Zeb-2 might be important for inducing EMT, and IL-6 might be a poten... BeFree,CTD_human,GAD,LHGDN 24833103 Detail
0.167 liver carcinoma The effects of IL6/IGFI on stemness expression in HCC were examined using OCT4/N... BeFree,CTD_human,GAD,LHGDN 25564572 Detail
0.167 liver carcinoma Blocking interleukin 6 reversed the Tim-3-mediated effects on HCC cell growth in... BeFree,CTD_human,GAD,LHGDN 25608525 Detail
0.167 liver carcinoma Since c-Met has been identified as a new potential therapeutical target for pers... BeFree,CTD_human,GAD,LHGDN 25620570 Detail
0.167 liver carcinoma IL-6 levels of HCC patients with the W4P variant were significantly higher than ... BeFree,CTD_human,GAD,LHGDN 25645622 Detail
0.167 liver carcinoma Unlike previous studies, our results did not confirm FUCA1, HGF, IGF1 or CgA as ... BeFree,CTD_human,GAD,LHGDN 25862856 Detail
0.167 liver carcinoma These results indicate that PML modulates IL-6-induced STAT3 activation and hepa... BeFree,CTD_human,GAD,LHGDN 25892518 Detail
<0.001 Cryopyrin-Associated Periodic Syndromes NA BeFree Detail
0.002 Chronic kidney disease stage 5 NA BeFree Detail
<0.001 Chronic kidney disease stage 4 NA BeFree Detail
<0.001 Oropharyngeal Carcinoma NA BeFree Detail
<0.001 Beryllium Disease NA BeFree Detail
0.003 Allergic rhinitis (disorder) Association of interleukin 6 single nucleotide polymorphisms with allergic rhini... BeFree,GAD 24974143 Detail
0.120 Acute kidney injury NA CTD_human Detail
<0.001 Extramedullary Hematopoiesis (disorder) NA BeFree Detail
0.120 CROHN DISEASE-ASSOCIATED GROWTH FAILURE, SUSCEPTIBILITY TO (finding) NA CLINVAR Detail
<0.001 MYD88 Deficiency NA BeFree Detail
<0.001 Steatohepatitis NA BeFree Detail
<0.001 Alcoholic Steatohepatitis NA BeFree Detail
<0.001 Mixed phenotype acute leukemia NA BeFree Detail
<0.001 Infectious Otitis Media NA BeFree Detail
0.005 Weight Loss Adverse Event NA GAD Detail
0.002 Weight Gain Adverse Event NA GAD Detail
0.005 Infection of amniotic sac and membranes, unspecified, unspecified trimester, not applicable or unspecified NA GAD Detail
<0.001 Immunoglobulin a deficiency 1 NA BeFree Detail
0.003 Nasopharyngeal carcinoma NA BeFree Detail
<0.001 Obesity, Visceral The C allele at the -174 locus of IL-6 gene is independently associated with the... BeFree 25815341 Detail
0.001 Plaque, Amyloid NA BeFree Detail
<0.001 Intracavitary Tumors of the Heart NA BeFree Detail
0.007 Cerebral Hemorrhage NA GAD Detail
<0.001 Recurrent aphthous ulcer NA BeFree Detail
<0.001 Disturbance in mood NA BeFree Detail
0.003 Deficiency of glucose-6-phosphate dehydrogenase NA BeFree,GAD Detail
<0.001 limb ischemia NA BeFree Detail
<0.001 Pulmonary arterial hypertension NA BeFree Detail
<0.001 Anaplastic Medulloblastoma NA BeFree Detail
<0.001 Pregnancy Related Skin Change NA BeFree Detail
<0.001 Stage II Colon Cancer AJCC v7 NA BeFree Detail
<0.001 polycystic kidney disease 1 NA BeFree Detail
0.003 Stroke, Lacunar NA BeFree,GAD Detail
<0.001 Three Vessel Coronary Disease Age, increased BMI, diabetes, low ejection fraction, left main stenosis, and gen... BeFree 25526459 Detail
0.007 myelodysplastic syndrome NA GAD,LHGDN Detail
0.001 FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder) NA BeFree Detail
0.002 Hiatal Hernia NA GAD Detail
<0.001 Homocysteinemia NA BeFree Detail
0.017 Juvenile arthritis Data on the impact of acute and chronic physical activities on the secretion of ... BeFree,GAD,LHGDN 25936296 Detail
<0.001 Renal dysplasia NA BeFree Detail
<0.001 Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor Phosphoproteomic profiling reveals IL6-mediated paracrine signaling within the E... BeFree 25092916 Detail
<0.001 Progressive cGVHD NA BeFree Detail
<0.001 Triple Negative Breast Neoplasms NA BeFree Detail
<0.001 Allergic disposition NA BeFree Detail
<0.001 Basal-Like Breast Carcinoma IL-6 mRNA is detectable only in basal-like breast carcinoma tissues; our results... BeFree 25881039 Detail
<0.001 Discogenic pain NA BeFree Detail
<0.001 Bacterial sepsis of newborn NA BeFree Detail
<0.001 Intracranial glioma NA BeFree Detail
<0.001 Neutrophilia (disorder) By contrast, levels of the inflammatory cytokines IL-17A and IL-6 were significa... BeFree 25363529 Detail
<0.001 Melanocytic nevus of skin NA BeFree Detail
<0.001 Meckel syndrome type 1 NA BeFree Detail
0.038 Infection NA GAD,LHGDN Detail
<0.001 Dowling-Degos disease In the DDD group, there were 10 cytokines and growth factors with significantly ... BeFree 25365709 Detail
<0.001 Pneumonitis Associations of three well-characterized polymorphisms in the IL-6 and IL-10 gen... BeFree 25708204 Detail
<0.001 intellectual disability Involvement of IL-6 and IL-1 receptor antagonist on intellectual disability. BeFree 25124963 Detail
0.003 juvenile rheumatoid arthritis Data on the impact of acute and chronic physical activities on the secretion of ... BeFree 25936296 Detail
<0.001 Pulmonary hypertension, primary, 1, with hereditary hemorrhagic telangiectasia NA BeFree Detail
0.001 Experimental Organism Basal Cell Carcinoma NA BeFree Detail
<0.001 Metabolic disorders in children Association of IL-6 and CRP gene polymorphisms with obesity and metabolic disord... BeFree 25993353 Detail
<0.001 Infection in children NA BeFree Detail
<0.001 Clinical Chorioamnionitis NA BeFree Detail
<0.001 Disorder of Achilles tendon NA BeFree Detail
<0.001 Acute-On-Chronic Liver Failure Activation of STAT3 in response to IL-6 was elevated in ACLF patients. BeFree 24366287 Detail
0.213 rheumatoid arthritis Plasma soluble IL-6 receptor concentration in rheumatoid arthritis: associations... BeFree 20661738 Detail
0.226 multiple myeloma The IL-6 receptor rs8192284 was associated with an increased risk of hematologic... BeFree 24059848 Detail
0.125 Spontaneous abortion NA CTD_human,GAD Detail
0.002 Abortion, Habitual NA GAD Detail
<0.001 Acne Vulgaris The interleukin-6 and interleukin-1A gene promoter polymorphism is associated wi... BeFree 25432444 Detail
<0.001 acquired immunodeficiency syndrome NA BeFree Detail
<0.001 Acute alcoholic liver disease NA BeFree Detail
<0.001 Acute Disease NA BeFree Detail
0.004 acute pancreatitis Influence of interleukin-1β and interleukin-6 gene polymorphisms on the developm... BeFree,GAD 25730036 Detail
0.004 acute pancreatitis Elevated levels of CRP and IL-6 in subjects with severe form of AP on day 4 indi... BeFree,GAD 26554230 Detail
0.003 Acute-Phase Reaction NA LHGDN Detail
0.017 adenocarcinoma NA BeFree,GAD,LHGDN Detail
0.007 adenoma The Th17 cell differentiation simulators IL-1β and IL-6 were also shown in an in... BeFree,GAD,LHGDN 24859972 Detail
0.003 agammaglobulinemia NA LHGDN Detail
<0.001 Primary myelofibrosis NA BeFree Detail
<0.001 AIDS Dementia Complex NA BeFree Detail
<0.001 AIDS related complex NA BeFree Detail
0.120 Albuminuria NA CTD_human Detail
<0.001 Alcoholic Intoxication, Chronic NA BeFree Detail
0.005 Alveolar Bone Loss IL-6 plays critical roles in bone resorption and the pathogenesis of periodontit... BeFree,GAD 25576892 Detail
0.002 extrinsic allergic alveolitis NA GAD Detail
0.070 Alzheimer's disease NA BeFree,GAD,LHGDN Detail
0.123 Amnesia NA BeFree,CTD_human,GAD Detail
0.003 amyloidosis NA BeFree,GAD Detail
<0.001 Anaplasia NA BeFree Detail
0.005 anemia NA BeFree,LHGDN Detail
<0.001 Anemia of chronic disease NA BeFree Detail
<0.001 aplastic anemia NA BeFree Detail
<0.001 Refractory anaemia with excess blasts No differences were observed with respect to phenotype, differentiation capacity... BeFree 25679997 Detail
<0.001 Anemia, Sickle Cell Interleukin-1β and interleukin-6 gene polymorphisms are associated with manifest... BeFree 25595815 Detail
0.004 Aneurysm NA BeFree,LHGDN Detail
0.007 Angina Pectoris NA GAD Detail
0.011 Angina, Unstable NA BeFree,GAD,LHGDN Detail
0.005 Fabry disease NA BeFree,GAD,LHGDN Detail
<0.001 Anorexia NA BeFree Detail
0.003 anorexia nervosa NA LHGDN Detail
0.003 Anoxia NA LHGDN Detail
0.001 anthracosis NA BeFree Detail
<0.001 Anxiety Disorders Anxiety is associated with higher levels of global DNA methylation and altered e... BeFree 25350786 Detail
<0.001 aortic aneurysm NA BeFree Detail
0.002 Aortic Rupture NA GAD Detail
0.003 appendicitis NA BeFree,GAD Detail
0.007 Arterial Occlusive Diseases NA GAD Detail
0.013 arteriosclerosis Furthermore, sortilin also seems to be involved in the development of atheroscle... BeFree,GAD 25702058 Detail
0.003 Arteriovenous fistula NA BeFree,LHGDN Detail
0.008 Congenital arteriovenous malformation NA BeFree,LHGDN Detail
<0.001 Arthralgia NA BeFree Detail
0.019 arthritis Furthermore, local blockades of these growth factors suppressed the development ... BeFree,GAD,LHGDN 25556244 Detail
<0.001 Arthritis, Adjuvant-Induced NA BeFree Detail
0.002 Arthritis, Psoriatic NA GAD Detail
0.003 Ascites NA LHGDN Detail
0.002 asphyxia neonatorum NA GAD Detail
0.038 asthma In conclusion, using both bioinformatics and experimental tools we found a highl... BeFree,GAD,LHGDN 25360780 Detail
0.038 asthma JQ1/SGCBD01 and I-BET762 inhibited FCS+TGF-β-induced ASM cell proliferation and ... BeFree,GAD,LHGDN 25697361 Detail
0.038 asthma In this prospective cohort study, baseline airway IL-1β, serum C-reactive protei... BeFree,GAD,LHGDN 25950204 Detail
0.038 asthma Treatment of HASM cells with IL-6+sIL6R induced proliferation in a dose-dependen... BeFree,GAD,LHGDN 26001777 Detail
0.008 Astrocytoma NA BeFree,LHGDN Detail
0.171 atherosclerosis Furthermore, sortilin also seems to be involved in the development of atheroscle... BeFree,CTD_human,GAD,LHGDN 25702058 Detail
0.012 atrial fibrillation NA GAD,LHGDN Detail
0.121 autistic disorder NA BeFree,CTD_human Detail
0.136 Autoimmune Diseases In addition, we discuss the effect of targeting IL-6 in recent experimental and ... BeFree,CTD_human,GAD,LHGDN 24647663 Detail
0.136 Autoimmune Diseases Interleukin-6 (IL-6) is a critical regulator of the immune system and has been w... BeFree,CTD_human,GAD,LHGDN 24670876 Detail
0.136 Autoimmune Diseases Kawasaki disease was associated with higher IL-17A and IL-6, a cytokine profile ... BeFree,CTD_human,GAD,LHGDN 25585854 Detail
0.136 Autoimmune Diseases Evidence of elevated levels of the proinflammatory cytokine IL-6 has been routin... BeFree,CTD_human,GAD,LHGDN 25794663 Detail
0.136 Autoimmune Diseases Moreover, HGF/Met influences the inflammatory response of macrophages and the im... BeFree,CTD_human,GAD,LHGDN 26561593 Detail
<0.001 Melanoma, B16 NA BeFree Detail
0.002 Bacteremia NA GAD Detail
0.006 Bacterial Infections Markers for diagnosis of bacterial infection, which includedprocalcitonin (PCT),... BeFree,GAD,LHGDN 25881528 Detail
<0.001 Pneumonia, Bacterial NA BeFree Detail
0.005 Barrett esophagus NA GAD,LHGDN Detail
0.003 Behcet Syndrome Polymorphisms of interleukin 6 and interleukin 10 in Egyptian people with Behcet... BeFree,GAD 24703990 Detail
0.003 Behcet Syndrome Polymorphism of interleukin 6 -174 G/C in Behcet disease: case series and review... BeFree,GAD 25415812 Detail
<0.001 Benign Ovarian Neoplasm NA BeFree Detail
0.120 berylliosis NA CTD_human Detail
<0.001 biliary atresia Hepatic interleukin-6 (IL-6) expression was significantly elevated in BA patient... BeFree 25450715 Detail
0.002 Biliary Tract Neoplasm NA GAD Detail
<0.001 bipolar disorder As a result, IL-6, IL-8 and IFN related pathways held twice to thrice the number... BeFree 25855618 Detail
0.002 bird fancier's lung NA GAD Detail
0.016 Malignant neoplasm of urinary bladder Interleukin-12 and interleukin-6 gene polymorphisms and risk of bladder cancer i... BeFree,GAD 25292079 Detail
<0.001 Bladder Neoplasm NA BeFree Detail
0.003 Blood Coagulation Disorders NA BeFree,GAD Detail
0.001 Bone Diseases NA BeFree Detail
0.005 Metabolic Bone Disorder NA BeFree,GAD,LHGDN Detail
<0.001 Bone Marrow Diseases NA BeFree Detail
<0.001 Bone neoplasms NA BeFree Detail
<0.001 borderline personality disorder NA BeFree Detail
<0.001 Brain Diseases NA BeFree Detail
0.003 Brain Neoplasms NA BeFree,GAD Detail
0.003 bronchiolitis obliterans NA BeFree,LHGDN Detail
0.002 Bronchiolitis, Viral NA GAD Detail
0.002 bronchopneumonia NA GAD Detail
0.001 bronchopulmonary dysplasia NA BeFree Detail
0.014 brucellosis NA BeFree,GAD,LHGDN Detail
0.005 burning mouth syndrome NA LHGDN Detail
<0.001 bursitis NA BeFree Detail
0.007 Malignant tumor of colon Genomic instability causes HGF gene activation in colon cancer cells, promoting ... BeFree 25244939 Detail
0.007 Malignant tumor of colon Furthermore, cycling hypoxia-specific inflammatory phenotype, characterized by a... BeFree 25622900 Detail
0.007 Malignant tumor of colon The effectiveness of an anti-human IL-6 receptor monoclonal antibody combined wi... BeFree 25625841 Detail
0.007 Malignant tumor of colon 15-LOX-1 down-regulation was associated with IL-6 up-regulation in human colon c... BeFree 25713055 Detail
0.007 Malignant tumor of colon High interleukin-6 mRNA expression is a predictor of relapse in colon cancer. BeFree 25862884 Detail
0.007 Malignant tumor of colon Interleukin-1 Receptor Type 2 Acts with c-Fos to Enhance the Expression of Inter... BeFree 26209639 Detail
0.001 Malignant neoplasm of endometrium Overall, our results provide a preclinical rationale to target IL6 or its effect... BeFree 26130650 Detail
<0.001 Rectal Carcinoma NA BeFree Detail
<0.001 Malignant neoplasm of thyroid NA BeFree Detail
0.125 basal cell carcinoma NA CTD_human,GAD,LHGDN Detail
<0.001 Bronchogenic Carcinoma NA BeFree Detail
<0.001 Noninfiltrating Intraductal Carcinoma NA BeFree Detail
0.006 Non-small cell lung carcinoma Effects of AKT inhibition on HGF-mediated erlotinib resistance in non-small cell... BeFree 25323938 Detail
0.006 Non-small cell lung carcinoma Increased circulating CRP and IL-6 levels were significantly associated with poo... BeFree 25335739 Detail
0.006 Non-small cell lung carcinoma Usefulness of plasma HGF level for monitoring acquired resistance to EGFR tyrosi... BeFree 25338771 Detail
0.006 Non-small cell lung carcinoma NOX4/Akt and IL-6/STAT3 signalings can reciprocally and positively regulate each... BeFree 25504436 Detail
0.006 Non-small cell lung carcinoma Combining onartuzumab with erlotinib inhibits growth of non-small cell lung canc... BeFree 25522765 Detail
0.006 Non-small cell lung carcinoma IL-6 polymorphism in non-small cell lung cancer: a prognostic value? BeFree 25566963 Detail
0.006 Non-small cell lung carcinoma Significant impact of IL-6 -174G/C but inverse relation with -634 C/G polymorphi... BeFree 25942346 Detail
<0.001 Carcinoma, Papillary NA BeFree Detail
0.132 renal cell carcinoma p21-activated kinase 1 determines stem-like phenotype and sunitinib resistance v... BeFree,CTD_human,LHGDN 25675297 Detail
Annotation

Annotations

DescrptionSourceLinks
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Furthermore, our results suggested that urinary IL-8, IL-6 and CK-18 may benefit as noninvasive biom... DisGeNET Detail
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Whereas, the IL-6 -572G/C polymorphism showed that the variant genotype (GC+CC) was associated with ... DisGeNET Detail
The parallel relationship with history of CVD and incident CV events of the -174 G/C polymorphism in... DisGeNET Detail
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As in other matrix expansion disorders, IL-6 is upregulated and represents a logical target for immu... DisGeNET Detail
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Stratification analysis and case-control study of relationships between interleukin-6 gene polymorph... DisGeNET Detail
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At baseline, we found CD14, IL1R1 and TLR-1 were down-regulated significantly (≥2 fold change) and t... DisGeNET Detail
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In mice, IL-19 up-regulates TNFα and IL-6 expression and its deficiency increases susceptibility to ... DisGeNET Detail
Using two murine models of bowel injury - wound by biopsy and bacterial triggered colitis - we demon... DisGeNET Detail
Butein ameliorated colitis in IL-10(-/-) mice by regulating IL-6/STAT3 and MMP-9 activation. DisGeNET Detail
15-Lipoxygenase-1 suppression of colitis-associated colon cancer through inhibition of the IL-6/STAT... DisGeNET Detail
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The Th17 cell differentiation simulators IL-1β and IL-6 were also shown in an increase trend from th... DisGeNET Detail
Bradykinin stimulates IL-6 production and cell invasion in colorectal cancer cells. DisGeNET Detail
Th17-type cytokines, IL-6 and TNF-α synergistically activate STAT3 and NF-kB to promote colorectal c... DisGeNET Detail
Upregulation of TLRs and IL-6 as a marker in human colorectal cancer. DisGeNET Detail
Interleukin-6 (IL-6) promotes cellular proliferation and drug resistance in colorectal cancer, and i... DisGeNET Detail
Identification of 15-LOX-1 suppression of PPAR-δ to inhibit IL-6/STAT3 signaling-driven CAC tumorige... DisGeNET Detail
Differential role of MACC1 expression and its regulation of the HGF/c‑Met pathway between breast and... DisGeNET Detail
In this study, we demonstrate that fos-related antigen-1 (Fra-1) plays a critical role in IL-6 induc... DisGeNET Detail
EMAST-positive colorectal tumors had significantly higher levels of IL6 than EMAST-negative tumors. DisGeNET Detail
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Relationship between the interleukin-6-174 gene and mannose-binding lectin codon 54 gene polymorphis... DisGeNET Detail
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Association of IL6 single nucleotide polymorphisms with febrile seizures. DisGeNET Detail
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IL-6 gene promoter polymorphisms and risk of coronary artery disease in a Chinese population. DisGeNET Detail
Role of IL-6 polymorphism on the development of cardiovascular events and coronary artery disease in... DisGeNET Detail
IL-6 gene promoter polymorphisms and risk of coronary artery disease in a Chinese population. DisGeNET Detail
IL6R haplotype associations with C-reactive protein (CRP), fibrinogen, IL6, soluble IL6R (sIL6R), IL... DisGeNET Detail
Role of IL-6 polymorphism on the development of cardiovascular events and coronary artery disease in... DisGeNET Detail
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The levels of IL-6, soluble IL-6 receptor (sIL-6R), soluble gp130 (sgp130), and S100A8/9 from contro... DisGeNET Detail
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First, wild-type or IL-6(-/-) mice were injected with Cryptococcus neoformans (C. neoformans) and th... DisGeNET Detail
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However, IL6 genotype did not moderate the effects of non-interpersonal stress exposure (i.e., finan... DisGeNET Detail
STAT3 controls IL6-dependent regulation of serotonin transporter function and depression-like behavi... DisGeNET Detail
However, IL6 genotype did not moderate the effects of non-interpersonal stress exposure (i.e., finan... DisGeNET Detail
STAT3 controls IL6-dependent regulation of serotonin transporter function and depression-like behavi... DisGeNET Detail
TLR2 activation in skin resident cells triggered interleukin-6 (IL-6), which induced suppressive MDS... DisGeNET Detail
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All genes increased in response to initial stress (IL-6: F=3.8; p=0.029; IL-1β: F=7.1; p=0.008; NF-κ... DisGeNET Detail
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Genes in eczema related to epidermal barrier, reduced innate immunity, increased IL-6, and a TH2 sig... DisGeNET Detail
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Association of interleukin-6-572C/G gene polymorphism and serum or cerebrospinal fluid interleukin-6... DisGeNET Detail
Cells with JEV infection showed impaired LCFA β-oxidation and increased interleukin 6 (IL-6) and tum... DisGeNET Detail
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In this research, an IL6-associated miRNA, miR26a, was identified, and its normally downregulated ex... DisGeNET Detail
In this study, 14 single nucleotide variants (SNVs) in genes coding for interleukin-1β, interleukin-... DisGeNET Detail
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An increased level of IL-6 suppresses NK cell activity in peritoneal fluid of patients with endometr... DisGeNET Detail
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By contrast, levels of the inflammatory cytokines IL-17A and IL-6 were significantly elevated in the... DisGeNET Detail
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The present study supports that EB might be considered a systemic inflammatory disease rather than a... DisGeNET Detail
Genomic analysis of the interleukin-1β-511 and interleukin-6-174 gene polymorphisms in Turkish patie... DisGeNET Detail
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In a 4-NQO-induced esophageal tumor animal model, MDSC recruitment was associated with invasive esop... DisGeNET Detail
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Pro-inflammatory and antiviral cytokines (granulocyte macrophage colony stimulating factor, interfer... DisGeNET Detail
Genetic associations were established between fatigue and the G/G genotype of IL6-174 and TNF-308, a... DisGeNET Detail
For non-Hispanic whites, the IL1β -511 CC genotype was associated with a high overall symptom burden... DisGeNET Detail
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Children with FXS displayed similar innate immune response following challenge with LPS alone when c... DisGeNET Detail
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The p38-MK2-HuR pathway potentiates EGFRvIII-IL-1β-driven IL-6 secretion in glioblastoma cells. DisGeNET Detail
C/EBPβ promotes angiogenesis through secretion of IL-6, which is inhibited by genistein, in EGFRvIII... DisGeNET Detail
The study focused on the role of Oncostatin-M (OSM), an IL-6 family cytokine in inducing mesenchymal... DisGeNET Detail
Six genes independently correlated with either age (IL-6, TNFRSF-11B, IGFBP-3, SAA4, and COPG), prog... DisGeNET Detail
The effect of hBMVEC on C6 glioma sCp expression at the level of transcript and protein was represse... DisGeNET Detail
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Risk model incorporating donor IL6 and IFNG genotype and gastrointestinal GVHD can discriminate pati... DisGeNET Detail
Increased level of IL-37 in patients with GD are associated with TNF-α, IL-6, IL-17 and disease acti... DisGeNET Detail
Association of interleukin-6-572C/G gene polymorphism and serum or cerebrospinal fluid interleukin-6... DisGeNET Detail
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These data indicate that IL-1β and IL-6 gene SNPs are associated with SCA complications among Brazil... DisGeNET Detail
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In age, sex- and race- adjusted models, sIL-2Rα was positively associated with current smoking, type... DisGeNET Detail
In age, sex- and race- adjusted models, sIL-2Rα was positively associated with current smoking, type... DisGeNET Detail
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Consistently, mice injected with pAAV-HBV-B and pmIFN-α showed higher expression levels of the IFN-s... DisGeNET Detail
IL-6 promoter functional polymorphism -572C/G affects spontaneous clearance of hepatitis B virus inf... DisGeNET Detail
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Combined impact of hepatitis C virus genotype 1 and interleukin-6 and tumor necrosis factor-α polymo... DisGeNET Detail
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Association of TGFB1 29C/T and IL6 -572G/C polymorphisms with developmental hip dysplasia: a case-co... DisGeNET Detail
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The sEng, sFlt-1, and interleukin-6 were up-regulated, whereas the VEGF and PlGF were down-regulated... DisGeNET Detail
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A 10-fold reduction in IL-6 and a 5-fold decrease in hyaluronan, both linked to lung fibrosis and PH... DisGeNET Detail
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In addition, the cytokines IL-1β, IL-6 and IFN-γ may be potential targets for treating patients with... DisGeNET Detail
In area under curve analyses, post-LAIV IL-6 responses (P = 0.03) and influenza sequences (P = 0.01)... DisGeNET Detail
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Circulating inflammatory biomarkers, including tumor necrosis factor α (TNF-α), C-reactive protein (... DisGeNET Detail
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Inhibition of this pathway has led to successful treatment of rheumatoid arthritis, but one unforese... DisGeNET Detail
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Expression of IL-8, IL-6 and IL-1β in tears as a main characteristic of the immune response in human... DisGeNET Detail
We analyzed the gene expression levels of the key proteins LOX, collagens (COL IA1 and COL IVA1), MM... DisGeNET Detail
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IL-1β +3954C>T SNP was associated with increased risk of osteonecrosis, elevated pulmonary arterial ... DisGeNET Detail
Association of gene variants in TLR4 and IL-6 genes with Perthes disease. DisGeNET Detail
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Microenvironmental interleukin-6 suppresses toll-like receptor signaling in human leukemia cells thr... DisGeNET Detail
Chromatin immunoprecipitation (ChIP) and an electoromobility shift assay (EMSA) confirmed STAT3 occu... DisGeNET Detail
Our results provide evidence that the regulation of IL-6, IL-10, c-Jun, and STAT3 gene expression in... DisGeNET Detail
These results suggest IL-6 can act as tumor suppressor in CLL by inhibiting TLR-signaling. DisGeNET Detail
Therefore, have investigated whether or not the expression levels, of selected genes [tumor necrosis... DisGeNET Detail
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All subjects were genotyped for 13 polymorphic variants in the genes of xenobiotics detoxification C... DisGeNET Detail
We prospectively assessed the influence of 6 single nucleotide polymorphisms (SNPs) in TNFα, IL6, an... DisGeNET Detail
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A significantly higher frequency of IL6 and TGF-β double-high patients was detected in CH-C than in ... DisGeNET Detail
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These results indicate that PML modulates IL-6-induced STAT3 activation and hepatoma cell growth by ... DisGeNET Detail
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Our findings suggest that IL6 and SOCS3 play important roles in COPD and have the potential to serve... DisGeNET Detail
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In addition, blocking the autocrine-loop of IL-6 in SLE B cells with an anti-IL-6 receptor monoclona... DisGeNET Detail
Interleukin-6, interleukin-1 gene cluster and interleukin-1 receptor polymorphisms in Iranian patien... DisGeNET Detail
Increased tumor necrosis factor α (TNF-α) in SLE serum significantly inhibited the migration capacit... DisGeNET Detail
The cytokines IL-6 and IL-10 are produced by cells of the adaptive and innate arms of the immune sys... DisGeNET Detail
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All subjects were genotyped for 13 polymorphic variants in the genes of xenobiotics detoxification C... DisGeNET Detail
Participants with genotype combinations GC/CC/GG/GG and GG/CT/GG/GG (DDX39B-22/DDX39B-348/TNF-308/IL... DisGeNET Detail
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DDX39B (BAT1), TNF and IL6 gene polymorphisms and association with clinical outcomes of patients wit... DisGeNET Detail
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Clinical impact of the HGF/MET pathway activation in patients with advanced gastric cancer treated w... DisGeNET Detail
Additionally, signal transducer and activator of transcription 3 (STAT3) was also involved in the IL... DisGeNET Detail
IL-33 promotes gastric cancer cell invasion and migration by stimulating the secretion of MMP-3 and ... DisGeNET Detail
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These results suggest that SPINT2 is associated with tumor-suppressive functions in melanoma by inhi... DisGeNET Detail
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In this study we investigated the role of IL-6 in Cryptococcus meningitis. DisGeNET Detail
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Through this activation, proinflammatory cytokines, such as Interleukin-6 (IL-6) and C-reactive prot... DisGeNET Detail
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The interleukin-6 (IL-6)/Janus kinase (JAK)/signal transducer and activator of transcription 3 (STAT... DisGeNET Detail
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Kawasaki disease was associated with higher IL-17A and IL-6, a cytokine profile similar to other aut... DisGeNET Detail
In this study, we examined changes in gene expression profile in human mesenchymal stem cells (MSCs)... DisGeNET Detail
Down-regulation of interleukin 6 (IL6) by berberine might lead to inhibition of miR-21 transcription... DisGeNET Detail
A HGF/cMET autocrine loop is operative in multiple myeloma bone marrow endothelial cells and may rep... DisGeNET Detail
Thalidomide (Thal) has been used to treat multiple myeloma due to its inhibitory effects on IL-6-ind... DisGeNET Detail
In this study, we demonstrated that Senp1 is overexpressed and induced by IL-6 in multiple myeloma c... DisGeNET Detail
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Furthermore, the production of IL-17 and IL-6 by MS-derived T cells was directly related with neurol... DisGeNET Detail
Taken together, our data indicate an important role for miR26a in maintaining the Th17 and Treg cell... DisGeNET Detail
Nonapoptotic and extracellular activity of granzyme B mediates resistance to regulatory T cell (Treg... DisGeNET Detail
Seeking balance: Potentiation and inhibition of multiple sclerosis autoimmune responses by IL-6 and ... DisGeNET Detail
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B cells produce less IL-10, IL-6 and TNF-α in myasthenia gravis. DisGeNET Detail
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Gram-positive bacterial and fungal infections did not cause a marked increase in IL-6 or IL- 10 leve... DisGeNET Detail
The infected IL-6(-/-) mice had significantly larger brain fungal burdens than wild-type mice. DisGeNET Detail
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IL6R haplotype associations with C-reactive protein (CRP), fibrinogen, IL6, soluble IL6R (sIL6R), IL... DisGeNET Detail
HGF/Met has beneficial effects against myocardial infarction and endothelial dysfunction: the cellul... DisGeNET Detail
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The levels of IL-6, soluble IL-6 receptor (sIL-6R), soluble gp130 (sgp130), and S100A8/9 from contro... DisGeNET Detail
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In transformed cells, enforced expression of SOCS3 or interfering with IL6 pathway via IL6R blockade... DisGeNET Detail
The neutralizing assays suggested that interleukin-6 (IL-6) had an indispensable role in RMP regulat... DisGeNET Detail
Interleukin-6 (IL-6) is an important cytokine that activates the signal transduction, promotes tumor... DisGeNET Detail
More intriguingly, by skewing macrophages polarization away from the M1- to a tumor-promoting M2-lik... DisGeNET Detail
NK1 induces all three HGF activities at modestly reduced potency, whereas NK2 stimulates only motoge... DisGeNET Detail
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The results of the current study demonstrated that pro-inflammatory cytokines, including TGF-β1, IL-... DisGeNET Detail
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A meta-analysis was conducted on the association between the IL-6 polymorphism and knee OA. DisGeNET Detail
Several genes, including IL-6 encoding pro-inflammatory cytokines, are involved in development of os... DisGeNET Detail
Possible interactions of the TNFα SNPs with variants in the previously reported IL1β and IL6 genes i... DisGeNET Detail
Using rabbit and human synovial fibroblast cell lines, we examined the effects of Cx43 overexpressio... DisGeNET Detail
These findings implicate miR-9-mediated suppression of MCPIP-1 in the pathogenesis of OA via up-regu... DisGeNET Detail
These results support our hypothesis that miR-139-mediated downregulation of MCPIP1 promotes IL-6 ex... DisGeNET Detail
Transforming growth factor-β1 (TGF-beta1) and interleukin-6 (IL-6) are included in pathogenesis of O... DisGeNET Detail
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Association of interleukin-6 gene polymorphisms with hand osteoarthritis and hand osteoporosis. DisGeNET Detail
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HGF/c-Met axis drives cancer aggressiveness in the neo-adjuvant setting of ovarian cancer. DisGeNET Detail
In addition, we found that the expression level of IL6 was correlated with activation of STAT3 in ov... DisGeNET Detail
Ovarian cancer ascites were collected from patients, and we found that primary CD11b+CD14+ cells, wh... DisGeNET Detail
Adaptive Upregulation of EGFR Limits Attenuation of Tumor Growth by Neutralizing IL6 Antibodies, wit... DisGeNET Detail
HGF expression in four ovarian cancer cell lines was evaluated by using semi-quantitative polymerase... DisGeNET Detail
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For other patients, the IL6 -174 GG genotype predicted moderate/severe pain (OR, 3.36; 95% CI, 1.23-... DisGeNET Detail
At the same location of pain assessment and fibroblast sampling, in situ immunohistochemical (IHC)(+... DisGeNET Detail
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Administration of MSCs alone significantly reduced pancreatic injury and inflammation, as reflected ... DisGeNET Detail
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Thus, IL-6 plays pivotal roles in both paraneoplastic syndrome and the oncogenesis of AFH. DisGeNET Detail
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miR-155 and miR-146b negatively regulates IL6 in Helicobacter pylori (cagA+) infected gastroduodenal... DisGeNET Detail
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Relationships between IL-6 gene polymorphism, low BMD and periodontitis in postmenopausal women. DisGeNET Detail
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Associations of three well-characterized polymorphisms in the IL-6 and IL-10 genes with pneumonia: a... DisGeNET Detail
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Association of TNF-alpha, IL-6 and IL-1beta gene polymorphisms with polycystic ovary syndrome: a met... DisGeNET Detail
The results of the meta-analysis suggest positive associations between the TNF-α -1031 T>C and IL-6 ... DisGeNET Detail
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EGCG rapidly induced mitochondria-localized reactive oxygen species in human oral squamous carcinoma... DisGeNET Detail
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IL-6 can convert non-ALDH(high) cells to ALDH(high) cells in prostate cancer cell line as well as fr... DisGeNET Detail
Together with our previous observation that EGR3 is highly expressed in prostate tumours compared wi... DisGeNET Detail
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IL6 -174G>C polymorphism is associated with an increased risk of psoriasis but not response to treat... DisGeNET Detail
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The protective effects of bLF against hyperoxia were further confirmed by significant reductions in ... DisGeNET Detail
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In vitro studies revealed that Thal decreased 1) the expression of IL-1β and IL-6 in human lung epit... DisGeNET Detail
A 10-fold reduction in IL-6 and a 5-fold decrease in hyaluronan, both linked to lung fibrosis and PH... DisGeNET Detail
Furthermore, the DEGs of SOCS3, IL4, IL18R1, IL1R1, and IL6 were participated in the disease of pulm... DisGeNET Detail
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IL-6 levels in plasma were significantly (p<0.001) decreased in hwt-APC and hS360A-PC treated mice. DisGeNET Detail
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IL-1β +3954C>T SNP was associated with increased risk of osteonecrosis, elevated pulmonary arterial ... DisGeNET Detail
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Our analysis revealed evidence for multiple associations between genetic variants in the PVR, PVRL2,... DisGeNET Detail
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We report significant increases in PPARγ, SREBP1, IL-6 and TNFα, and decreases in PPARα and C/EPBα a... DisGeNET Detail
Family-based association study of interleukin 6 (IL6) and its receptor (IL6R) functional polymorphis... DisGeNET Detail
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Patients with postoperative sepsis were significantly (p = 0.002) more likely to possess AA homozygo... DisGeNET Detail
The protection of female hearts against the dysfunction associated with sepsis is (at least in part)... DisGeNET Detail
Plasma was analysed by ELISA for thrombin-antithrombin complex (TAT), D-dimer as markers of coagulat... DisGeNET Detail
Analysis of 1163 miRNAs from PBMCs revealed that miR-182, miR-143, miR-145, miR-146a, miR-150, and m... DisGeNET Detail
In summary, this work provides the first in vivo evidence that administering BMMSCs or UCMSCs to rat... DisGeNET Detail
Association between IL-6-174G/C polymorphism and the risk of sepsis and mortality: a systematic revi... DisGeNET Detail
The combination of markers (hs-CRP, PCT, and IL-6) is better than single markers to diagnose sepsis. DisGeNET Detail
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Neutralization of tumor necrosis factor-α and IL-6 (both downstream of IL-17A) reduced skin lesions,... DisGeNET Detail
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While the elderly group exhibited robust changes in immune activity such as increased production of ... DisGeNET Detail
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Our findings have implications for the use of cancer therapies that target VEGF or IL6 and for under... DisGeNET Detail
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We investigated the role of activated B cells in thrombopoiesis through the production of interleuki... DisGeNET Detail
Single nucleotide polymorphisms in interleukin-6 and their association with venous thromboembolism. DisGeNET Detail
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When early stage and late stage CSF cytokines were compared, IL-10 and IL-6 were up regulated in lat... DisGeNET Detail
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Independent and joint effects of the IL-6 and IL-10 gene polymorphisms in pulmonary tuberculosis amo... DisGeNET Detail
We also performed the analyses by sample types in IL-6 -174 C/G polymorphism, and significant decrea... DisGeNET Detail
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To investigate microvessel density (MVD), vascular endothelial growth factor (VEGF), endothelial nit... DisGeNET Detail
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New cytokine inhibitors targeting IL-1 and IL-6 appear to be effective especially for uveitis and CN... DisGeNET Detail
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Isolated PBMCs from O. volvulus-infected individuals (164 MF(+) and 46 a-MF) and non-infected volunt... DisGeNET Detail
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We found a significant increase in interleukin (IL)-1β plasmatic levels of DEB (P = 0.0224) and EBS ... DisGeNET Detail
We found a significant increase in interleukin (IL)-1β plasmatic levels of DEB (P = 0.0224) and EBS ... DisGeNET Detail
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CD38 and interleukin 6 gene polymorphism in egyptians with diffuse large B-cell lymphoma (DLBCL). DisGeNET Detail
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Targeting VEGF and interleukin-6 for controlling malignant effusion of primary effusion lymphoma. DisGeNET Detail
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The levels of interleukin-1α (IL-1α), IL-1β, IL-6, IL-12(p70), and IL-8 were elevated, whereas the I... DisGeNET Detail
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The ability of PGA to induce TNF-α and IL-6 was retained in TLR4(-/-) but not TLR2(-/-) BMDMs. DisGeNET Detail
Overall, 82.9% of children with Gram-negative bacterial infections were accompanied by marked increa... DisGeNET Detail
Lack of IL-6 increases blood-brain barrier permeability in fungal meningitis. DisGeNET Detail
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Interleukin-6 upregulates Th17 response via mTOR/STAT3 pathway in acute-on-chronic hepatitis B liver... DisGeNET Detail
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Effects of chronic interpersonal stress exposure on depressive symptoms are moderated by genetic var... DisGeNET Detail
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The interleukin-6 (IL-6)/Janus kinase (JAK)/signal transducer and activator of transcription 3 (STAT... DisGeNET Detail
Age-related increased prevalence of asthma and nasal polyps in chronic rhinosinusitis and its associ... DisGeNET Detail
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The levels of inflammatory cytokines IL-6, IL-8, IL-1β and TNF-α in the HNE2 cell group after EBV in... DisGeNET Detail
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In conclusion, IL-6 -DNMT3b axis could be used to predict the prognosis of oral cancer in clinics, a... DisGeNET Detail
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We aimed to investigate whether the functional genetic variants rs8192284 and rs2228044 previously a... DisGeNET Detail
IL6R genetic variations, especially SNP7 (rs8192284, Asp358Ala), were significantly associated with ... DisGeNET Detail
IL6R genetic variations, especially SNP7 (rs8192284, Asp358Ala), were significantly associated with ... DisGeNET Detail
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HGF and TGFβ1 of bone-metastasis microenvironment acted co-ordinately, influencing non redundant pat... DisGeNET Detail
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Malnutrition is more frequently associated in children with IL-6 174 G allele carriers (GG and CG ge... DisGeNET Detail
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Moreover, IL-6 expression decreased significantly in SMG ACCs compared with that in normal SMG, wher... DisGeNET Detail
Polymorphisms in the TNFA and IL6 genes represent risk factors for autoimmune thyroid disease. DisGeNET Detail
The microenvironment of glioblastoma (GBM) contains high levels of inflammatory cytokine interleukin... DisGeNET Detail
Moreover, we evaluated the relationship between MDSC recruitment, IL-6 levels, and tumor progression... DisGeNET Detail
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Genetic association of IL-6, TNF-α and SDF-1 polymorphisms with serum cytokine levels in diabetic fo... DisGeNET Detail
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Cultured human Tenon's capsule fibroblasts were exposed to transforming growth factor-β1, IL-6, homo... DisGeNET Detail
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There are reports that interleukin 6 (IL-6) may play an important role in the pathogenesis of opisth... DisGeNET Detail
Interleukin 6 (IL-6)-mediated signal transducers and activators of transcription 3 (STAT-3) phosphor... DisGeNET Detail
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In conclusion, IL-6 -DNMT3b axis could be used to predict the prognosis of oral cancer in clinics, a... DisGeNET Detail
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Apoptosis, caspase activity, and cytokine production (IL-6, IL-10, TNF-β, and IFN-γ) of T cells co-c... DisGeNET Detail
REG3A accelerates pancreatic cancer cell growth under IL-6-associated inflammatory condition: Involv... DisGeNET Detail
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Mutant MMP-9 and HGF gene transfer enhance resolution of CCl4-induced liver fibrosis in rats: role o... DisGeNET Detail
HGF-overexpressing ADSCs ameliorated radiation- induced liver fibrosis through down regulation of α-... DisGeNET Detail
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Furthermore, disruption of IL-6 effectively suppressed dilatation and rupture of the dissected aorta... DisGeNET Detail
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Furthermore, the homeostasis model assessment of insulin resistance (HOMA-IR) index and serum proinf... DisGeNET Detail
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They provide rationale for the implication of IL-6 in AMD and open avenues toward therapies inhibiti... DisGeNET Detail
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Patients with postoperative sepsis were significantly (p = 0.002) more likely to possess AA homozygo... DisGeNET Detail
The protection of female hearts against the dysfunction associated with sepsis is (at least in part)... DisGeNET Detail
Plasma was analysed by ELISA for thrombin-antithrombin complex (TAT), D-dimer as markers of coagulat... DisGeNET Detail
Analysis of 1163 miRNAs from PBMCs revealed that miR-182, miR-143, miR-145, miR-146a, miR-150, and m... DisGeNET Detail
In summary, this work provides the first in vivo evidence that administering BMMSCs or UCMSCs to rat... DisGeNET Detail
Association between IL-6-174G/C polymorphism and the risk of sepsis and mortality: a systematic revi... DisGeNET Detail
The combination of markers (hs-CRP, PCT, and IL-6) is better than single markers to diagnose sepsis. DisGeNET Detail
More intriguingly, by skewing macrophages polarization away from the M1- to a tumor-promoting M2-lik... DisGeNET Detail
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The use of bisphosphonates and IL-6 inhibitors has been explored to be useful in the treatment of fi... DisGeNET Detail
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Association of interleukin-6 gene polymorphisms with hand osteoarthritis and hand osteoporosis. DisGeNET Detail
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The association of IL-6 and IL-6R gene polymorphisms with chronic periodontitis in a Chinese populat... DisGeNET Detail
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Furthermore, proinflammatory cytokines TNF-α, IL-1β, IFN-γ, IL-6 were up-regulated in the CSOM group... DisGeNET Detail
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Moreover, we suggest inhibition of IL-6 as a potential strategy for the treatment of esophageal SCC. DisGeNET Detail
The protein levels of STAT3, phosphorylated STAT3, VEGF, NF-κB p65, phosphorylated NF-κB p65 and COX... DisGeNET Detail
The role of HGF/MET and FGF/FGFR in fibroblast-derived growth stimulation and lapatinib-resistance o... DisGeNET Detail
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Taken together, our results offer a preclinical rationale to combine anti-IL6 and gefitinib to treat... DisGeNET Detail
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Stratification analysis and case-control study of relationships between interleukin-6 gene polymorph... DisGeNET Detail
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The aim of the present study was to establish the role of IL-6 and TGF-β1 gene polymorphisms in the ... DisGeNET Detail
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IEGs, IL-1B, and IL-6 were overexpressed in smokers with severe active GO compared to nonsmokers, su... DisGeNET Detail
We also examined mucosal expression of IL-6, which stimulates excess GAG synthesis in disorders such... DisGeNET Detail
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HGF may be involved in gland invagination deep into the myometrium by inducing EMT at the endo-myome... DisGeNET Detail
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Similarly, patients with IH exhibit significantly lower IL6 mRNA expression and higher STS and HSD17... DisGeNET Detail
As a consequence, vIL-6 can activate many cell types that are unresponsive to cellular IL-6, contrib... DisGeNET Detail
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Apoptosis, caspase activity, and cytokine production (IL-6, IL-10, TNF-β, and IFN-γ) of T cells co-c... DisGeNET Detail
REG3A accelerates pancreatic cancer cell growth under IL-6-associated inflammatory condition: Involv... DisGeNET Detail
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miR-155 and miR-146b negatively regulates IL6 in Helicobacter pylori (cagA+) infected gastroduodenal... DisGeNET Detail
Interestingly, release of IL-6 and IL-8 after RSV, but not HRV, infection was synergistically increa... DisGeNET Detail
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Regulation of SOD2 and β-arrestin1 by interleukin-6 contributes to the increase of IGF-1R expression... DisGeNET Detail
Prostate cancer is frequently associated with elevated levels of interleukin-6 (IL-6), which exerts ... DisGeNET Detail
IL-6 can convert non-ALDH(high) cells to ALDH(high) cells in prostate cancer cell line as well as fr... DisGeNET Detail
Analysis of inflammatory genes in the patient tissues revealed that IL-6 expression was the highest ... DisGeNET Detail
Early Growth Response 3 regulates genes of inflammation and directly activates IL6 and IL8 expressio... DisGeNET Detail
Cellular Vaccines Modified with Hyper IL6 or Hyper IL11 Combined with Docetaxel in an Orthotopic Pro... DisGeNET Detail
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In addition, decreased numbers of CD4+ and CD8+ T lymphocytes and increased levels of TNF-α, IL-6 an... DisGeNET Detail
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Association of interleukin-6 gene polymorphisms with hand osteoarthritis and hand osteoporosis. DisGeNET Detail
Association of interleukin-6 promoter polymorphism with knee osteoarthritis: a meta-analysis. DisGeNET Detail
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Overall, our results provide a preclinical rationale to target IL6 or its effector functions as a no... DisGeNET Detail
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We evaluated the plasma fatty acid (FA) response to a DHA-rich supplement in APOE4 carriers and nonc... DisGeNET Detail
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The expression of pluripotency-related genes is associated with early tumor recurrence and is regula... DisGeNET Detail
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Association of IL-6 polymorphism -174G/C and metabolic syndrome in hypertensive patients. DisGeNET Detail
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Interleukin-6 upregulates Th17 response via mTOR/STAT3 pathway in acute-on-chronic hepatitis B liver... DisGeNET Detail
Characterisation of the cytokine milieu associated with the up-regulation of IL-6 and suppressor of ... DisGeNET Detail
The aim of this study was to assess whether two-years treatment with Pirfenidone influences necroinf... DisGeNET Detail
We investigated the association between hepatitis C virus (HCV) genotypes and host cytokine gene pol... DisGeNET Detail
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Interleukin-6 and tumor necrosis factor-alpha gene polymorphisms in chronic idiopathic urticaria. DisGeNET Detail
Role of IFN-γ and IL-6 cytokines and their association in determining susceptibility to chronic idio... DisGeNET Detail
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Chronic inflammation is an established risk factor for the onset of cancer, and the inflammatory cyt... DisGeNET Detail
Collectively, our data reveal that a key molecular mechanism by which NNK promotes tumour cell proli... DisGeNET Detail
Overall, the present data suggested that ITGB1 upregulation was involved in the regulation of tumori... DisGeNET Detail
Co-targeting c-Met and COX-2 leads to enhanced inhibition of lung tumorigenesis in a murine model wi... DisGeNET Detail
Although IL-17RA signaling also controls the production of IL-6, this mechanism makes only a partial... DisGeNET Detail
IL-6 originated from breast cancer tissue-derived mesenchymal stromal cells may contribute to carcin... DisGeNET Detail
PPAR-δ overexpression in colonic epithelial cells promoted CAC tumorigenesis in mice and increased I... DisGeNET Detail
The inhibition of p38 MAPK in PDXs results in downregulation of the IL-6/STAT3 signaling pathway, wh... DisGeNET Detail
The interleukin-6 (IL-6)/Janus kinase (JAK)/signal transducer and activator of transcription 3 (STAT... DisGeNET Detail
Thus, IL-6 plays pivotal roles in both paraneoplastic syndrome and the oncogenesis of AFH. DisGeNET Detail
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Activation of the MET/HGF pathway is common in human cancer and is thought to promote tumor initiati... DisGeNET Detail
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Regulation of SOD2 and β-arrestin1 by interleukin-6 contributes to the increase of IGF-1R expression... DisGeNET Detail
Prostate cancer is frequently associated with elevated levels of interleukin-6 (IL-6), which exerts ... DisGeNET Detail
IL-6 can convert non-ALDH(high) cells to ALDH(high) cells in prostate cancer cell line as well as fr... DisGeNET Detail
Analysis of inflammatory genes in the patient tissues revealed that IL-6 expression was the highest ... DisGeNET Detail
Early Growth Response 3 regulates genes of inflammation and directly activates IL6 and IL8 expressio... DisGeNET Detail
Cellular Vaccines Modified with Hyper IL6 or Hyper IL11 Combined with Docetaxel in an Orthotopic Pro... DisGeNET Detail
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The allele C in IL6-174 G/C is also associated with Hashimoto's thyroiditis, however, only retained ... DisGeNET Detail
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We also performed the analyses by sample types in IL-6 -174 C/G polymorphism, and significant decrea... DisGeNET Detail
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New cytokine inhibitors targeting IL-1 and IL-6 appear to be effective especially for uveitis and CN... DisGeNET Detail
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The FAIM3:PLAC8 ratio outperformed plasma procalcitonin and IL-8 and IL-6 in discriminating between ... DisGeNET Detail
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Genomic instability causes HGF gene activation in colon cancer cells, promoting their resistance to ... DisGeNET Detail
Furthermore, cycling hypoxia-specific inflammatory phenotype, characterized by a simultaneous (bacul... DisGeNET Detail
The effectiveness of an anti-human IL-6 receptor monoclonal antibody combined with chemotherapy to t... DisGeNET Detail
15-LOX-1 down-regulation was associated with IL-6 up-regulation in human colon cancer mucosa. DisGeNET Detail
High interleukin-6 mRNA expression is a predictor of relapse in colon cancer. DisGeNET Detail
Interleukin-1 Receptor Type 2 Acts with c-Fos to Enhance the Expression of Interleukin-6 and Vascula... DisGeNET Detail
Clinical impact of the HGF/MET pathway activation in patients with advanced gastric cancer treated w... DisGeNET Detail
Additionally, signal transducer and activator of transcription 3 (STAT3) was also involved in the IL... DisGeNET Detail
IL-33 promotes gastric cancer cell invasion and migration by stimulating the secretion of MMP-3 and ... DisGeNET Detail
Interleukin-12 and interleukin-6 gene polymorphisms and risk of bladder cancer in the Iranian popula... DisGeNET Detail
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IL-6 trans-signaling increases expression of airways disease genes in airway smooth muscle. DisGeNET Detail
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The interleukin-6 and interleukin-1A gene promoter polymorphism is associated with the pathogenesis ... DisGeNET Detail
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While IL6, CCL2 and CCR5-mRNA, and CD68 were overexpressed in the tubulointerstitial compartment in ... DisGeNET Detail
In conclusion, the results suggest that CXCL10 and IL-6 have important roles in the occurrence and p... DisGeNET Detail
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The synthesis of IL6 and IL8 proteins induced by PRP is decreased significantly in the presence of h... DisGeNET Detail
Association between the interleukin-6 gene polymorphisms and renal cancer risk. DisGeNET Detail
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Persistent production of IL-6, in turn, contributes to T cell expansion and the functional hyperacti... DisGeNET Detail
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Furthermore, the production of IL-17 and IL-6 by MS-derived T cells was directly related with neurol... DisGeNET Detail
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Mammospheres (MS) from node invasive breast carcinoma tissues express IL-6 mRNA at higher levels tha... DisGeNET Detail
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IL-8 > IL-6 in patients with bacterial keratitis; IL-8 > IL-6 > IL-1β and increased frequency of cir... DisGeNET Detail
PCT had greater diagnostic value than did hs-CRP and IL-6, while IL-6 was better for diagnosis of ne... DisGeNET Detail
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Neutralization of tumor necrosis factor-α and IL-6 (both downstream of IL-17A) reduced skin lesions,... DisGeNET Detail
HGF/Met has beneficial effects against myocardial infarction and endothelial dysfunction: the cellul... DisGeNET Detail
Risk model incorporating donor IL6 and IFNG genotype and gastrointestinal GVHD can discriminate pati... DisGeNET Detail
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These results suggest that SPINT2 is associated with tumor-suppressive functions in melanoma by inhi... DisGeNET Detail
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However, Dkk-1 levels showed an inverse correlation with IL-6 levels in both SpA SF (r = -0.31, P = ... DisGeNET Detail
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While this therapy has caused toxicities, including cytokine release syndrome and macrophage activat... DisGeNET Detail
Inhibition of natural killer cell cytotoxicity by interleukin-6: implications for the pathogenesis o... DisGeNET Detail
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HGF/c-Met axis drives cancer aggressiveness in the neo-adjuvant setting of ovarian cancer. DisGeNET Detail
In addition, we found that the expression level of IL6 was correlated with activation of STAT3 in ov... DisGeNET Detail
Ovarian cancer ascites were collected from patients, and we found that primary CD11b+CD14+ cells, wh... DisGeNET Detail
Adaptive Upregulation of EGFR Limits Attenuation of Tumor Growth by Neutralizing IL6 Antibodies, wit... DisGeNET Detail
HGF expression in four ovarian cancer cell lines was evaluated by using semi-quantitative polymerase... DisGeNET Detail
Overall, the IL1α/IL1R/MYD88/IL6 pathway may be responsible for the reduced antitumor efficacy of er... DisGeNET Detail
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IL-6 572 C/G, 190 C/T, and 174 G/C gene polymorphisms in children's malnutrition. DisGeNET Detail
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Additionally, IL-6 polymorphism could influence lymphocytic infiltration of salivary glands and dimi... DisGeNET Detail
IL-8 > IL-6 in patients with bacterial keratitis; IL-8 > IL-6 > IL-1β and increased frequency of cir... DisGeNET Detail
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Thus, IL-6 plays pivotal roles in both paraneoplastic syndrome and the oncogenesis of AFH. DisGeNET Detail
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Following disease induction, daily systemic administration of human recombinant Anx-A1 (hrAnx-A1), d... DisGeNET Detail
IL-6 is a major causative factor of inflammatory disease. DisGeNET Detail
Whole-Body In Vivo Monitoring of Inflammatory Diseases Exploiting Human Interleukin 6-Luciferase Tra... DisGeNET Detail
The present study supports that EB might be considered a systemic inflammatory disease rather than a... DisGeNET Detail
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Targeting VEGF and interleukin-6 for controlling malignant effusion of primary effusion lymphoma. DisGeNET Detail
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By contrast, levels of the inflammatory cytokines IL-17A and IL-6 were significantly elevated in the... DisGeNET Detail
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In the in vitro experiments, LPS preconditioning of ASCs enhanced the mRNA expression levels of inte... DisGeNET Detail
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Further preclinical study might reveal the potential use of zerumbone as a chemotherapeutic agent fo... DisGeNET Detail
In particular, strong preclinical evidence for the aberrant activation of the HGF/c-Met signaling pa... DisGeNET Detail
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IL-6 expression was significantly higher in mesenchymal tumors, and knockdown of IL-6 in mesenchymal... DisGeNET Detail
Expression of NF-κB appears to be related to the level of the neoplastic differentiation only in the... DisGeNET Detail
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Association between the interleukin-6 gene polymorphisms and renal cancer risk. DisGeNET Detail
PBMCs harvested from patients with systemic JIA during periods of active or inactive disease were le... DisGeNET Detail
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Association of gene variants in TLR4 and IL-6 genes with Perthes disease. DisGeNET Detail
The tumor necrosis factor-α -238G/A and IL-6 -572G/C gene polymorphisms and the risk of idiopathic d... DisGeNET Detail
Polymorphisms of tumor necrosis factor-alpha and interleukin-6 gene and C-reactive protein profiles ... DisGeNET Detail
Genetic association of IL-6, TNF-α and SDF-1 polymorphisms with serum cytokine levels in diabetic fo... DisGeNET Detail
Immunofluorescent staining of human primary and secondary breast tumours showed significant correlat... DisGeNET Detail
Interleukin-6 and pro inflammatory status in the breast tumor microenvironment. DisGeNET Detail
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Cirp deficiency reduced production of interleukin-1β and interleukin-6 in Kupffer cells, ROS accumul... DisGeNET Detail
Based on these findings and a drug screening study, we demonstrated that combined inhibition of AAG8... DisGeNET Detail
Senescent cells secrete various growth factors and cytokines, such as IL-6, that can signal to the t... DisGeNET Detail
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In transformed cells, enforced expression of SOCS3 or interfering with IL6 pathway via IL6R blockade... DisGeNET Detail
The Th17 cell differentiation simulators IL-1β and IL-6 were also shown in an increase trend from th... DisGeNET Detail
Bradykinin stimulates IL-6 production and cell invasion in colorectal cancer cells. DisGeNET Detail
Th17-type cytokines, IL-6 and TNF-α synergistically activate STAT3 and NF-kB to promote colorectal c... DisGeNET Detail
Upregulation of TLRs and IL-6 as a marker in human colorectal cancer. DisGeNET Detail
Interleukin-6 (IL-6) promotes cellular proliferation and drug resistance in colorectal cancer, and i... DisGeNET Detail
Identification of 15-LOX-1 suppression of PPAR-δ to inhibit IL-6/STAT3 signaling-driven CAC tumorige... DisGeNET Detail
Differential role of MACC1 expression and its regulation of the HGF/c‑Met pathway between breast and... DisGeNET Detail
In this study, we demonstrate that fos-related antigen-1 (Fra-1) plays a critical role in IL-6 induc... DisGeNET Detail
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In this study, 14 single nucleotide variants (SNVs) in genes coding for interleukin-1β, interleukin-... DisGeNET Detail
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Interleukin-6 (IL-6) is one of the inflammation biomarkers with highest predictive value for outcome... DisGeNET Detail
Association of IL-6 and a functional polymorphism in the IL-6 gene with cardiovascular events in pat... DisGeNET Detail
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We prospectively assessed the influence of 6 single nucleotide polymorphisms (SNPs) in TNFα, IL6, an... DisGeNET Detail
As a consequence, vIL-6 can activate many cell types that are unresponsive to cellular IL-6, contrib... DisGeNET Detail
By contrast, levels of the inflammatory cytokines IL-17A and IL-6 were significantly elevated in the... DisGeNET Detail
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Expression of both IL-6 (P = .024) and CD36 (P = .018) was greater in PAD subjects than in healthy s... DisGeNET Detail
Thus administration of HGF or HGF mimetics may represent a promising therapeutic agent for the treat... DisGeNET Detail
Mammospheres (MS) from node invasive breast carcinoma tissues express IL-6 mRNA at higher levels tha... DisGeNET Detail
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Age-related increased prevalence of asthma and nasal polyps in chronic rhinosinusitis and its associ... DisGeNET Detail
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Overall, our results provide a preclinical rationale to target IL6 or its effector functions as a no... DisGeNET Detail
IL-6 gene promoter polymorphisms and risk of coronary artery disease in a Chinese population. DisGeNET Detail
Role of IL-6 polymorphism on the development of cardiovascular events and coronary artery disease in... DisGeNET Detail
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Furthermore, our results suggested that urinary IL-8, IL-6 and CK-18 may benefit as noninvasive biom... DisGeNET Detail
RMP promotes venous metastases of hepatocellular carcinoma through promoting IL-6 transcription. DisGeNET Detail
TNFα (G-238A, C-863A, G-308A), IL6 (C-174G), and IL1β (C-31T, C-511T) SNPs were assessed in 232 alco... DisGeNET Detail
Twist-1 and Zeb-2 might be important for inducing EMT, and IL-6 might be a potential therapeutic tar... DisGeNET Detail
The effects of IL6/IGFI on stemness expression in HCC were examined using OCT4/NANOG promoter lucife... DisGeNET Detail
Blocking interleukin 6 reversed the Tim-3-mediated effects on HCC cell growth in vitro. DisGeNET Detail
Since c-Met has been identified as a new potential therapeutical target for personalized treatment o... DisGeNET Detail
IL-6 levels of HCC patients with the W4P variant were significantly higher than those of patients wi... DisGeNET Detail
Unlike previous studies, our results did not confirm FUCA1, HGF, IGF1 or CgA as potential markers fo... DisGeNET Detail
These results indicate that PML modulates IL-6-induced STAT3 activation and hepatoma cell growth by ... DisGeNET Detail
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Association of interleukin 6 single nucleotide polymorphisms with allergic rhinitis. DisGeNET Detail
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The C allele at the -174 locus of IL-6 gene is independently associated with the occurrence of metab... DisGeNET Detail
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Age, increased BMI, diabetes, low ejection fraction, left main stenosis, and genetic variation in th... DisGeNET Detail
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Data on the impact of acute and chronic physical activities on the secretion of hormones and other m... DisGeNET Detail
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Phosphoproteomic profiling reveals IL6-mediated paracrine signaling within the Ewing sarcoma family ... DisGeNET Detail
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IL-6 mRNA is detectable only in basal-like breast carcinoma tissues; our results reveal that IL-6 tr... DisGeNET Detail
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By contrast, levels of the inflammatory cytokines IL-17A and IL-6 were significantly elevated in the... DisGeNET Detail
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In the DDD group, there were 10 cytokines and growth factors with significantly increased expression... DisGeNET Detail
Associations of three well-characterized polymorphisms in the IL-6 and IL-10 genes with pneumonia: a... DisGeNET Detail
Involvement of IL-6 and IL-1 receptor antagonist on intellectual disability. DisGeNET Detail
Data on the impact of acute and chronic physical activities on the secretion of hormones and other m... DisGeNET Detail
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Association of IL-6 and CRP gene polymorphisms with obesity and metabolic disorders in children and ... DisGeNET Detail
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Activation of STAT3 in response to IL-6 was elevated in ACLF patients. DisGeNET Detail
Plasma soluble IL-6 receptor concentration in rheumatoid arthritis: associations with the rs8192284 ... DisGeNET Detail
The IL-6 receptor rs8192284 was associated with an increased risk of hematologic malignancy (combine... DisGeNET Detail
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The interleukin-6 and interleukin-1A gene promoter polymorphism is associated with the pathogenesis ... DisGeNET Detail
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Influence of interleukin-1β and interleukin-6 gene polymorphisms on the development of acute pancrea... DisGeNET Detail
Elevated levels of CRP and IL-6 in subjects with severe form of AP on day 4 indicate a diagnostic ut... DisGeNET Detail
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The Th17 cell differentiation simulators IL-1β and IL-6 were also shown in an increase trend from th... DisGeNET Detail
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IL-6 plays critical roles in bone resorption and the pathogenesis of periodontitis in both inflammat... DisGeNET Detail
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No differences were observed with respect to phenotype, differentiation capacity, immunomodulatory c... DisGeNET Detail
Interleukin-1β and interleukin-6 gene polymorphisms are associated with manifestations of sickle cel... DisGeNET Detail
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Anxiety is associated with higher levels of global DNA methylation and altered expression of epigene... DisGeNET Detail
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Furthermore, sortilin also seems to be involved in the development of atherosclerosis, by mechanisms... DisGeNET Detail
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Furthermore, local blockades of these growth factors suppressed the development of cytokine-induced ... DisGeNET Detail
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In conclusion, using both bioinformatics and experimental tools we found a highly relevant potential... DisGeNET Detail
JQ1/SGCBD01 and I-BET762 inhibited FCS+TGF-β-induced ASM cell proliferation and IL-6 and CXCL8 relea... DisGeNET Detail
In this prospective cohort study, baseline airway IL-1β, serum C-reactive protein, and IL-6 were ass... DisGeNET Detail
Treatment of HASM cells with IL-6+sIL6R induced proliferation in a dose-dependent fashion, suggestin... DisGeNET Detail
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Furthermore, sortilin also seems to be involved in the development of atherosclerosis, by mechanisms... DisGeNET Detail
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In addition, we discuss the effect of targeting IL-6 in recent experimental and clinical studies on ... DisGeNET Detail
Interleukin-6 (IL-6) is a critical regulator of the immune system and has been widely implicated in ... DisGeNET Detail
Kawasaki disease was associated with higher IL-17A and IL-6, a cytokine profile similar to other aut... DisGeNET Detail
Evidence of elevated levels of the proinflammatory cytokine IL-6 has been routinely observed during ... DisGeNET Detail
Moreover, HGF/Met influences the inflammatory response of macrophages and the immune response of den... DisGeNET Detail
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Markers for diagnosis of bacterial infection, which includedprocalcitonin (PCT), interleukin-6 (IL-6... DisGeNET Detail
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Polymorphisms of interleukin 6 and interleukin 10 in Egyptian people with Behcet's disease. DisGeNET Detail
Polymorphism of interleukin 6 -174 G/C in Behcet disease: case series and review of literature. DisGeNET Detail
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Hepatic interleukin-6 (IL-6) expression was significantly elevated in BA patients and BDL rats, whil... DisGeNET Detail
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As a result, IL-6, IL-8 and IFN related pathways held twice to thrice the number of expected variant... DisGeNET Detail
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Interleukin-12 and interleukin-6 gene polymorphisms and risk of bladder cancer in the Iranian popula... DisGeNET Detail
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Genomic instability causes HGF gene activation in colon cancer cells, promoting their resistance to ... DisGeNET Detail
Furthermore, cycling hypoxia-specific inflammatory phenotype, characterized by a simultaneous (bacul... DisGeNET Detail
The effectiveness of an anti-human IL-6 receptor monoclonal antibody combined with chemotherapy to t... DisGeNET Detail
15-LOX-1 down-regulation was associated with IL-6 up-regulation in human colon cancer mucosa. DisGeNET Detail
High interleukin-6 mRNA expression is a predictor of relapse in colon cancer. DisGeNET Detail
Interleukin-1 Receptor Type 2 Acts with c-Fos to Enhance the Expression of Interleukin-6 and Vascula... DisGeNET Detail
Overall, our results provide a preclinical rationale to target IL6 or its effector functions as a no... DisGeNET Detail
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Effects of AKT inhibition on HGF-mediated erlotinib resistance in non-small cell lung cancer cell li... DisGeNET Detail
Increased circulating CRP and IL-6 levels were significantly associated with poor prognosis especial... DisGeNET Detail
Usefulness of plasma HGF level for monitoring acquired resistance to EGFR tyrosine kinase inhibitors... DisGeNET Detail
NOX4/Akt and IL-6/STAT3 signalings can reciprocally and positively regulate each other, leading to e... DisGeNET Detail
Combining onartuzumab with erlotinib inhibits growth of non-small cell lung cancer with activating E... DisGeNET Detail
IL-6 polymorphism in non-small cell lung cancer: a prognostic value? DisGeNET Detail
Significant impact of IL-6 -174G/C but inverse relation with -634 C/G polymorphism in patients with ... DisGeNET Detail
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p21-activated kinase 1 determines stem-like phenotype and sunitinib resistance via NF-κB/IL-6 activa... DisGeNET Detail

Overlapped Transcript Coordinates

Gene Transcript ID Exon Number Chromosome Start Stop Type Amino Mutation Transcript Position Links

Overlapped Transcript

Gene Transcript ID Chromosome Start Stop Links
Gene
-
dbSNP
rs4340 dbSNP
Genome
hg19
Position
chr7:22,765,503-22,771,621
Variant Type
snv
Genome browser