Dry Eye Syndromes
Information
- Disease name
- Dry Eye Syndromes
- Disease ID
- Description
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
| Genes | Mutation | Description | Source | Links |
|---|
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT06404541 | Active, not recruiting | Phase 4 | A Comparative Study Between Preservative With Benzalkonium Chloride vs Preservative Free Eye Drops on the Ocular Surface | January 10, 2024 | May 2024 |
| NCT05814757 | Active, not recruiting | Phase 2 | OTX-DED for the Short-term Treatment of the Symptoms of Dry Eye Disease (DED) | May 11, 2023 | May 31, 2024 |
| NCT05763940 | Active, not recruiting | N/A | Efficacy of OmegaBoost to Increase Omega-3 Levels in Healthy Individuals | May 25, 2022 | June 25, 2024 |
| NCT03697876 | Active, not recruiting | Phase 1 | Safety and Tolerability of the Ophthalmic Gel PRO-165 Versus Artelac® Nightime Gel | September 30, 2018 | November 30, 2024 |
| NCT00357201 | Completed | Phase 2 | Efficacy of T1675 Versus Placebo in Patients With Bilateral Treated Moderate Dry Eye Syndrome | November 2004 | May 2005 |
| NCT00370747 | Completed | Phase 2 | Efficacy and Safety Study for Ecabet Ophthalmic Solution for Treating Dry Eye Syndrome | September 2006 | June 2007 |
| NCT00372034 | Completed | N/A | The Effect of Punctal Plugs on Tear Volume and Osmolality | July 2006 | March 2007 |
| NCT00386646 | Completed | Phase 4 | Comparative Study of 0.5% Carboxymethylcellulose With 0.005% Stabilized Oxychlorocomplex (PURITE™) Versus 0.5% Carboxymethylcellulose in the Treatment of Dry Eye | February 2004 | October 2005 |
| NCT00469157 | Completed | Phase 4 | Refractive Surgery and Optive Compatibility Study | May 2007 | April 2008 |
| NCT00475319 | Completed | Phase 2 | Late Phase 2 Study of OPC-12759 Ophthalmic Suspension | May 2007 | June 2008 |
| NCT00502073 | Completed | Phase 3 | Study of Cyclosporine in the Treatment of Dry Eye Syndrome (ST-603-005) | ||
| NCT00548301 | Completed | Phase 3 | Study of Cyclosporine in the Treatment of Dry Eye Syndrome (ST-603-007) | ||
| NCT00549289 | Completed | Phase 3 | Study of Cyclosporine in the Treatment of Dry Eye Syndrome (ST-603-006) | ||
| NCT00611403 | Completed | Phase 2 | Safety and Efficacy Study of Cyclosporine Ophthalmic Emulsion in Post-LASIK Patients | December 2007 | June 2009 |
| NCT00620893 | Completed | Phase 4 | Bilateral, Masked Comparison of PEG-400 Based Artificial Tear vs. Systane for Dry Eye Signs, Symptoms & Refractive Regression Associated With Myopic Laser in Situ Keratomilieusis (LASIK). | February 2008 | May 2009 |
| NCT00721656 | Completed | Phase 2 | Phase 2 Study of KLS-0611 in Patients With Dry Eye Syndromes | ||
| NCT00731484 | Completed | Validation of TearLab Osmometer - Human Factor Usability Report | July 2008 | March 2009 | |
| NCT00739713 | Completed | N/A | Effects of Sea Buckthorn Oil on Dry Eye | September 2008 | March 2009 |
| NCT00756678 | Completed | Phase 4 | Efficacy and Acceptability of Two Lubricant Eye Drops | September 2008 | August 2009 |
| NCT00761202 | Completed | Phase 4 | Performance and Acceptance of Optive Versus Hylocomod Eyedrops in Patients With Dry Eye Symptoms | August 2007 | June 2008 |
| NCT00761917 | Completed | Diagnostic Evaluation of the Tear Film | June 2008 | November 2008 | |
| NCT00784719 | Completed | Phase 1/Phase 2 | A Prospective, Randomized, Placebo and Active Comparator Controlled Study of CP-690,550 in Subjects With Dry Eye. | November 2008 | October 2009 |
| NCT00788229 | Completed | Phase 2 | Efficacy and Safety Study of ATs in Patients With Dry Eye Syndrome | November 2008 | August 2009 |
| NCT00818324 | Completed | Phase 3 | Long Term Administration Study of OPC-12759 Ophthalmic Suspension | January 2009 | January 2011 |
| NCT00832130 | Completed | N/A | Treatment of Meibomian Gland Dysfunction and Evaporative Dry Eye | February 2009 | August 2009 |
| NCT00885079 | Completed | Phase 3 | Confirmatory Study of OPC-12759 Ophthalmic Suspension | May 2009 | April 2010 |
| NCT00938704 | Completed | Phase 4 | Study to Compare the Efficacy and Safety of Two Non-Preserved Artificial Tears for the Treatment of Dry Eye Signs and Symptoms | June 2009 | June 2009 |
| NCT00969280 | Completed | Phase 3 | Acupuncture for Dry Eye Syndrome | September 2009 | December 2009 |
| NCT00987727 | Completed | Phase 4 | Safety and Efficacy of Carboxymethylcellulose for Ocular Surface Integrity in Symptomatic Dry Eye | November 2009 | September 2010 |
| NCT01015209 | Completed | Phase 1 | Safety and Tolerability of Chitosan-N-acetylcysteine Eye Drops in Healthy Young Volunteers | September 2010 | January 2011 |
| NCT01027013 | Completed | Phase 2 | Safety and Efficacy Study of Rebamipide 2% Ophthalmic Suspension in Patients With Dry Eye | December 2009 | November 2010 |
| NCT01102257 | Completed | Phase 2/Phase 3 | Dry Eye Assessment and Management: Feasibility Study | January 2010 | March 2011 |
| NCT01135511 | Completed | Phase 2 | A Phase II, Dose Ranging Study Of CP-690,550 Eye Drops In Patients With Dry Eye Disease | July 2010 | April 2011 |
| NCT01176045 | Completed | TearLab Refractive Surgery Dry Eye Study | June 2010 | December 2011 | |
| NCT01202747 | Completed | Phase 2/Phase 3 | Evaluation of Screening Methods for Treatment of Meibomian Gland Dysfunction | September 2010 | January 2011 |
| NCT01211951 | Completed | Phase 2 | A Study of KCT-0809 in Patients With Dry Eye Syndromes | ||
| NCT01268735 | Completed | Phase 4 | The Effect of Ocular Lubricant Eyedrops on Lid Parallel Conjunctival Folds and Other Signs and Symptoms of Dry Eye | April 2009 | February 2010 |
| NCT01278784 | Completed | Phase 1 | Local Tolerability of Chitosan-N-acetylcysteine Eye Drops in Healthy Young Volunteers | March 2011 | September 2011 |
| NCT01280110 | Completed | Phase 4 | The Effects of BAK on the Blood Aqueous Barrier of Pseudophakic Patients | March 2011 | January 2012 |
| NCT01294384 | Completed | Phase 3 | Safety and Efficacy Study of New Eye Drop Formulations With Refresh Tears® in Patients With Dry Eye Disease | May 1, 2011 | September 25, 2012 |
| NCT01319773 | Completed | Phase 1 | Study of Two Formulations of Cyclosporine Ophthalmic Emulsion in Healthy Volunteers and in Patients With Dry Eye | November 2010 | January 2011 |
| NCT01427816 | Completed | Phase 2 | A Phase II Study of KCT-0809 in Patients With Dry Eye Syndrome | ||
| NCT01434277 | Completed | N/A | Safety Evaluation of a New Preservative in a Lubricating Eye Drop | April 2011 | April 2011 |
| NCT01459588 | Completed | Phase 3 | Safety, Efficacy, and Acceptability Study of an Eye Drop Formulation in Subjects With Dry Eye Disease | October 1, 2011 | February 15, 2012 |
| NCT01471093 | Completed | Phase 1 | Safety Study of OPC-12759 Ophthalmic Solution | November 2011 | February 2012 |
| NCT01479790 | Completed | N/A | Repeatability and Agreement of Anterior Segment Optical Coherence Tomography (AS-OCT) and Thermography | June 2011 | December 2012 |
| NCT01496482 | Completed | Comparison of Evaporimetry With the Established Methods of Tear Film Measurement | September 2008 | February 2009 | |
| NCT01558999 | Completed | Phase 2 | A Clinical Study Evaluating the Safety and Efficacy of SI-614 Ophthalmic Solution in Patients With Dry Eye | March 2012 | |
| NCT01568593 | Completed | Phase 3 | Comparison of the Efficacy and Safety of T2750 and Vismed® in the Treatment of Moderate to Severe Dry Eye Syndrome | March 2012 | March 2013 |
| NCT01684852 | Completed | Non Interventional Study to Evaluate the Efficacy and Tolerability of Ectoin Containing Ophthalmic Solution | May 2012 | ||
| NCT01692145 | Completed | Phase 2 | A Parallel Group Phase II Study of KCT-0809 in Patients With Dry Eye Syndromes | ||
| NCT01711424 | Completed | An Observational Study of OPTIVE PLUS® for the Treatment of Dry Eye Disease | September 2012 | March 2013 | |
| NCT01768312 | Completed | Phase 3 | Study of Cyclosporine Ophthalmic Soution Group and Cyclosporine Ophthalmic Suspension Group | August 23, 2012 | July 31, 2013 |
| NCT01804361 | Completed | Phase 3 | Efficacy and Safety Study of Haporine-S for Treatment of Moderate to Severe Dry Eye Syndromes | March 2013 | February 2014 |
| NCT01826812 | Completed | Impairment of Reading Ability in Dry Eye Patients | April 2013 | November 2015 | |
| NCT01840787 | Completed | N/A | A Pilot Study on the Use of a Sensory Panel to Assess Comfort Between Three Different Contact Lenses | April 2013 | January 2014 |
| NCT01854905 | Completed | An Observational Study of Dry Eye Prior to Laser-Assisted in Situ Keratomileusis (LASIK) Therapy | May 2013 | September 2013 | |
| NCT01882413 | Completed | A Study to Determine the Prevalence of Inflammatory Dry Eye Disease in Patients Prior to Cataract Removal | June 2013 | March 2014 | |
| NCT01890941 | Completed | Phase 2 | A Late Phase II Study of KCT-0809 in Patients With Dry Eye Syndromes | ||
| NCT01960010 | Completed | Phase 3 | A Safety and Efficacy Study of MIM-D3 Ophthalmic Solution for the Treatment of Dry Eye | October 2013 | August 2014 |
| NCT02011776 | Completed | A Randomized, Parallel-Group Comparison Study of Topical Corticosteroids in Dry Eye Patients With Sjögren Syndrome | March 2013 | November 2013 | |
| NCT00198536 | Completed | Phase 2/Phase 3 | Efficacy and Safety Study for Ecabet Ophthalmic Solution for Treating Dry Eye Syndrome | April 2005 | December 2005 |
| NCT00234078 | Completed | Phase 2 | Dose-response Study of OPC-12759 Ophthalmic Suspension | January 2005 | March 2007 |
| NCT00284999 | Completed | Phase 4 | Soothe Versus Refresh | August 2006 | |
| NCT00349440 | Completed | Phase 4 | Efficacy of Cyclosporine for the Prevention and Treatment of Dry Eye Symptoms Following LASIK or Photorefractive Keratectomy | September 2006 | September 2008 |
| NCT02526290 | Completed | N/A | Six Month Study to Evaluate the Safety and Effectiveness of the Intranasal Lacrimal Neurostimulator | August 31, 2015 | April 30, 2016 |
| NCT02553772 | Completed | Phase 3 | A Safety and Efficacy Study of a New Eye Drop Formulation in Patients With Dry Eye Disease. | January 6, 2016 | September 9, 2016 |
| NCT02554981 | Completed | Phase 4 | Evaluation of Maintaining Visual Performance in Participants Who Engage in Electronic Visual Tasking While Using Restasis® | July 21, 2015 | March 24, 2016 |
| NCT02585453 | Completed | Phase 4 | Influence of Lachrymal Substitute Gels on Tear Film Thickness in Patients With Moderate to Severe Dry Eye Syndrome | April 2015 | November 2015 |
| NCT02585648 | Completed | N/A | Added Benefits of Lachrymal Substitute Gel During the Night in Patients With Moderate to Severe Dry Eye Syndrome | February 2016 | November 2016 |
| NCT02608489 | Completed | N/A | Clinical Effects and Safety of 3% Diquafosol After Cataract Surgery | January 2014 | January 2015 |
| NCT02617667 | Completed | Phase 2 | CyclASol for the Treatment of Moderate to Severe Dry-eye Disease (DED) | January 2016 | September 2016 |
| NCT02621593 | Completed | N/A | Feasibility of IPL for Reducing Dry Eye Symptoms Caused by MGD | October 2015 | January 2017 |
| NCT02683382 | Completed | N/A | Effects of a Moisturizing Product on Dry Eye and Skin | March 2016 | July 2016 |
| NCT02802150 | Completed | N/A | The Effect of Oral Zanthoxylum Schinifolium Seed Oil in Individuals With Dry Eye Disease | February 2015 | February 2016 |
| NCT02813265 | Completed | Phase 3 | Safety and Efficacy of KPI-121 in Subjects With Dry Eye Disease | June 2016 | October 2017 |
| NCT02819284 | Completed | Phase 3 | Safety and Efficacy of KPI-121 Compared to Placebo in Subjects With Dry Eye Disease | June 2016 | September 2017 |
| NCT02851654 | Completed | Interest of Eye Movement Measurements in the Comprehension of Dry Eyes Symptoms | November 5, 2014 | October 30, 2019 | |
| NCT02871440 | Completed | Phase 3 | A Two Comparator, Controlled Phase 3 Study in Patients With and Without Evaporative Dry Eye | September 19, 2016 | September 18, 2017 |
| NCT02908282 | Completed | N/A | Topical Omega-3 Fatty Acids (REMOGEN® OMEGA) in the Treatment of Dry Eye | October 2016 | July 2018 |
| NCT02910713 | Completed | N/A | Evaluation of Dry Eye Symptoms in CAE With Application of Intranasal Neurostimulation | September 30, 2016 | October 31, 2016 |
| NCT02956083 | Completed | N/A | The Effect of Tear Supplements on Contact Lens Comfort | July 2014 | July 2015 |
| NCT02970799 | Completed | N/A | Tear Production by Nasal Neurostimulation Compared to Active Control | August 31, 2016 | October 31, 2016 |
| NCT02980913 | Completed | N/A | Difference in the Frequency of Use of Lachrymal Substitutes in Patients With Moderate to Severe Dry Eye Syndrome | February 11, 2016 | May 17, 2016 |
| NCT02986750 | Completed | Phase 4 | Influence of Three Different Formulations of Lachrymal Substitutes on Tear Film Thickness and Other Signs and Symptoms in Patients With Moderate to Severe Dry Eye Syndrome | February 13, 2016 | March 23, 2017 |
| NCT03012698 | Completed | N/A | Pilot Study for Testing Safety of Repetitive Magnetic Stimulation for Treatment of Dry Eye | November 1, 2017 | June 17, 2019 |
| NCT03052140 | Completed | N/A | Lamelleye vs Comparator for the Treatment of Dry Eye Disease | February 21, 2017 | August 9, 2017 |
| NCT03097614 | Completed | N/A | Dry Eye Symptom Relief Assessment With Use of TrueTear in a Controlled Adverse Environment | March 31, 2017 | June 26, 2017 |
| NCT03161080 | Completed | N/A | Effect of Single Instillation of Three Different Topical Lubricants on Tear Film Thickness in Patients With Dry Eye Syndrome | February 9, 2017 | May 12, 2017 |
| NCT03162783 | Completed | Phase 2 | A Randomized, Double Masked, Clinical Study of Subjects With Dry Eye Syndrome | May 15, 2017 | July 6, 2017 |
| NCT03183089 | Completed | Phase 4 | Comparative Study of Rohto Dry-Aid® and Systane® Ultra in Patients With Dry Eye | December 3, 2015 | January 4, 2016 |
| NCT03226769 | Completed | N/A | Safety and Efficacy of TrueTear™ for the Treatment of Meibomian Gland Disease | July 26, 2017 | December 12, 2017 |
| NCT03302273 | Completed | N/A | Corneal Epithelial Stem Cells and Dry Eye Disease | February 1, 2019 | April 1, 2022 |
| NCT03318874 | Completed | Phase 4 | Optimization of the Treatment of Dry Eye Disease Caused by Meibomian Gland Dysfunction | October 19, 2017 | November 17, 2021 |
| NCT03325673 | Completed | N/A | Clinical Trial to Evaluate the Symptoms in Symptomatic Contact Lens Wearers Following Application of Intranasal Tear Neurostimulator Versus Control | November 22, 2017 | November 29, 2018 |
| NCT03380624 | Completed | Phase 4 | Tear Lipid Layer Thickness With Emollient Eye Drops | March 1, 2017 | June 30, 2018 |
| NCT03417505 | Completed | N/A | Tangible Hydra-PEG: A Promising Solution for Scleral Lens Wearers With Dry Eye | January 30, 2018 | January 4, 2019 |
| NCT03518398 | Completed | Phase 3 | Effectiveness and Safety of Intense Pulsed Light in Patients With Meibomian Gland Dysfunction | July 3, 2018 | April 2, 2019 |
| NCT03524157 | Completed | Phase 1 | Safety and Tolerability of PRO-087 Versus Xyel Ofteno® and Systane Ultra®, on the Ocular Surface of Healthy Subjects | July 17, 2017 | March 27, 2018 |
| NCT03527212 | Completed | Phase 3 | A Study to Assess the Safety and Effectiveness of SJP-0035 for the Treatment of Patients With Dry Eye Disease | August 20, 2018 | March 15, 2019 |
| NCT03608761 | Completed | Phase 4 | Comparison Between Rebamipide 2% Versus Autologous Serum | February 6, 2017 | July 9, 2018 |
| NCT03617315 | Completed | N/A | Crosslinked Hyaluronic Acid With Liposomes and Crocin in Dry Eye | October 1, 2017 | March 20, 2018 |
| NCT03706443 | Completed | N/A | Tear Lipid Layer Thickness Changes With Use of Emollient and Non-Emollient Eye Drops | December 5, 2018 | February 28, 2019 |
| NCT03719885 | Completed | N/A | TrueTear in Sjogren's Disease Patients | December 1, 2018 | December 31, 2019 |
| NCT03723811 | Completed | Phase 2 | Clinical Study to Investigate the Efficacy and Safety of SJP002 Ophthalmic Solution in Patients With Dry Eye Syndrome. | November 28, 2017 | June 26, 2018 |
| NCT03803748 | Completed | N/A | A Non-inferiority Study of Eyestil® Plus Multidose Versus Vismed Multi® | July 17, 2019 | August 31, 2022 |
| NCT03821415 | Completed | Phase 2 | Effects of RP101 in Post-menopausal Women With Dry Eye Syndrome | January 18, 2019 | November 18, 2019 |
| NCT03874429 | Completed | N/A | Efficacy of T2259 in DED | April 24, 2019 | March 25, 2021 |
| NCT03937882 | Completed | Phase 3 | Assessment of the Safety and Efficacy of RGN-259 Ophthalmic Solutions for Dry Eye Syndrome: ARISE-3 | May 24, 2019 | October 7, 2021 |
| NCT03945071 | Completed | N/A | The Effect of Punctal Plugs on Ocular Surface After Povidone-Iodine Preparation of Intravitreal Injection | June 1, 2019 | October 18, 2020 |
| NCT03968731 | Completed | N/A | Meibomian Gland Dysfunction Management With ZEST Protocol | June 10, 2019 | May 31, 2020 |
| NCT04063644 | Completed | N/A | Quality of Life and Visual Acuity of Visglyc Eye Drops on Dry Eye Patients | May 30, 2019 | December 22, 2020 |
| NCT04104997 | Completed | Phase 1 | A Clinical Trial to Evaluate the Safety, Tolerability and Pharmacokinetic Characteristics of GLH8NDE After Single and Mutiple Ocular Administrations in Healthy Korean and Caucasian Volunteers | September 26, 2019 | July 17, 2020 |
| NCT04127851 | Completed | Phase 4 | Evaluating HA 0.15% Compared With Cyclosporine 0.05%, and Efficacy of Combination Therapy in Dry Eye Disease Patients | November 12, 2019 | October 14, 2021 |
| NCT04147962 | Completed | Intense Pulsed Light in Meibomian Gland Dysfunctions | October 25, 2019 | June 1, 2020 | |
| NCT04165785 | Completed | N/A | Efficiency and Changes of Cytokines Expression in Tear After Intense Pulsed Light Treating Dry Eye Disease | August 20, 2018 | July 28, 2019 |
| NCT04184999 | Completed | Phase 4 | Effect of Intraoperative Dexamethasone on Post-op Dry Eye | August 10, 2019 | December 1, 2019 |
| NCT04237012 | Completed | Phase 4 | ACCURATE Study for Subjects With Dry Eyes | December 16, 2019 | December 30, 2021 |
| NCT04280653 | Completed | N/A | An Open-Label, Multi-Center, Clinical Study Evaluating the Effect of the NDE L68 StableFit® Punctal Plug on the Tear Lake | August 28, 2019 | December 11, 2019 |
| NCT04310969 | Completed | N/A | Clinical Effect of MiboFlo in Dry Eye Patients | April 3, 2020 | June 30, 2020 |
| NCT04342988 | Completed | Phase 4 | Effect of Cequa Treatment on Accuracy of Pre-operative Biometry & Higher Order Aberrations in Dry Eye Patients Undergoing Cataract Surgery | April 8, 2020 | December 31, 2020 |
| NCT04384991 | Completed | Phase 3 | HU007 Eye Drops in Patients With Dry Eye Syndrome | May 3, 2019 | December 5, 2019 |
| NCT04413279 | Completed | Phase 4 | Lipiflow Treatment Alone vs. Lipiflow + Dextenza Treatment for Dry Eye Disease | August 1, 2020 | July 1, 2021 |
| NCT04426240 | Completed | Phase 4 | The Effect of Cyclosporin Before Cataract Surgery | August 3, 2020 | April 19, 2022 |
| NCT04454281 | Completed | Phase 1 | Topical Naloxone to Diagnose Ocular Pain | October 1, 2020 | December 3, 2020 |
| NCT04492878 | Completed | Phase 4 | Efficacy and Safety of Ikervis Under Controlled Environmental Conditions Environment | February 4, 2020 | January 18, 2021 |
| NCT04493658 | Completed | Differential Diagnosis of Sjögren's Versus Non-Sjögren's Dry Eye | January 11, 2021 | October 3, 2022 | |
| NCT04597762 | Completed | N/A | Effect of Ciclosporin Eyedrops on Sjögren Syndrome | August 31, 2020 | March 31, 2021 |
| NCT04637516 | Completed | N/A | Evaluation of an Updated Version of the Program "BlinkBlink" for Alleviation of Dry Eye Symptoms Induced by Computer Work | April 1, 2018 | August 17, 2018 |
| NCT04649177 | Completed | N/A | Pilot Study to Investigate the Feasibility, Reliability and Efficacy of Utilizing OCT to Automate PROSE Fitting | December 15, 2020 | March 23, 2022 |
| NCT04674358 | Completed | Phase 2/Phase 3 | The TRANQUILITY Trial: Clinical Trial to Assess the Efficacy and Safety in Subjects With Dry Eye Disease | November 21, 2020 | September 12, 2021 |
| NCT04835623 | Completed | Phase 4 | CEQUA for Sjogren's Syndrome Dry Eye | June 21, 2021 | March 21, 2024 |
| NCT04889950 | Completed | N/A | Clinical Study to Evaluate the Safety and Effectiveness of The Tixel Fractional System in the Treatment of Meibomian Gland Disfunction | October 26, 2021 | February 8, 2023 |
| NCT05002036 | Completed | Phase 4 | Management of Dry Eye Disease After Cataract Surgery With Topical Hyaluronic Acid and Gingko Biloba | February 1, 2021 | May 1, 2021 |
| NCT05017844 | Completed | Phase 2/Phase 3 | [KSR-001-P02] Phase 2b/3 Study, Evaluate the Efficacy and Safety of KSR-001 in Patients With Dry Eye Syndrome | February 18, 2020 | June 22, 2021 |
| NCT05017870 | Completed | Phase 1 | [KSR-001-P01]Clinical Trial to Evaluate the Safety, Tolerability and Pharmacokinetic Characteristic of KSR-001 | December 2, 2018 | January 15, 2020 |
| NCT05042960 | Completed | N/A | Computer Screen Properties Study | September 15, 2021 | January 12, 2023 |
| NCT05162261 | Completed | N/A | to Evaluate the Effectiveness and Safety of the Tixel® , VS LipiFlow® in the Treatment of Meibomian Gland Dysfunction | September 19, 2022 | September 28, 2023 |
| NCT05184517 | Completed | Early Phase 1 | A Feasibility Study to Evaluate the Tolerability of Oph1 Compared to Restasis in Healthy Volunteers | January 23, 2023 | September 5, 2023 |
| NCT05219461 | Completed | Phase 1 | Pharmacokinetics, Safety, and Tolerability of rhEGF Eye Drops in Healthy Male Subjects | March 29, 2019 | November 13, 2019 |
| NCT05292755 | Completed | Phase 4 | Effects of Carboxymethylcellulose Artificial Tears on the Eye Microbiome | April 22, 2022 | July 1, 2022 |
| NCT05424549 | Completed | Phase 2 | A Clinical Trial to Evaluate the Safety and Efficacy of Rreproxalap in Adults With Dry Eye Disease | March 9, 2022 | May 9, 2022 |
| NCT05425914 | Completed | Phase 3 | Impact of Vitamin D3 Supplementation in Non-Sjogren Dry Eye Patients With Low Serum Vitamin D Level | November 1, 2021 | April 30, 2022 |
| NCT05456061 | Completed | N/A | Effect of ADDE on Tear Interferometry | August 1, 2018 | January 31, 2022 |
| NCT05481450 | Completed | N/A | Efficacy and Safety Safety of Nutritears® in Adults With Dry Eye Syndrome | August 15, 2022 | May 22, 2023 |
| NCT05594745 | Completed | Phase 4 | Treatment Regimens in Meibomian Gland Dysfunction | March 2, 2021 | January 21, 2023 |
| NCT05598242 | Completed | Phase 3 | Amniotic Membrane Treatment for Hyposecretory Dry Eye | February 1, 2019 | December 15, 2019 |
| NCT05733624 | Completed | Phase 2 | Clinical Trial to Evaluate the Safety and Efficacy of SCAI-001 Compared to Restasis | January 5, 2023 | February 2, 2024 |
| NCT05778942 | Completed | Investigation of Preservative-Free Ophthalmic Solution in Ocular Dryness | February 23, 2023 | December 19, 2023 | |
| NCT05848128 | Completed | Phase 3 | Efficacy and Safety Evaluation of Tavilermide Ophthalmic Solution for the Treatment of Dry Eye | June 28, 2023 | May 11, 2024 |
| NCT06337981 | Completed | Phase 2 | Efficacy and Safety of AJU-S56 in Dry Eye Syndrome Patients | November 22, 2021 | November 28, 2022 |
| NCT02014922 | Completed | Phase 4 | A Study to Determine the Relief of Dry Eye Symptoms With the Use of TheraTears® Products (DUNLIN) | December 2013 | November 2014 |
| NCT02028754 | Completed | Phase 4 | A Study of Sodium Carboxymethylcellulose for Post Cataract Surgery Dry Eye Symptoms | July 2011 | May 2013 |
| NCT02117687 | Completed | Phase 4 | A Safety and Efficacy Study of OPTIVE FUSION™ With VISMED® Multi for the Management of Dry Eye | May 14, 2014 | March 17, 2015 |
| NCT02121847 | Completed | Phase 4 | Investigation of Maintaining Visual Performance Achieved With Cyclosporine Therapy | April 3, 2014 | September 23, 2014 |
| NCT02188160 | Completed | Phase 2 | Safety and Efficacy of KPI-121 in Subjects With Dry Eye Disease | June 2014 | March 2015 |
| NCT02205840 | Completed | Phase 2/Phase 3 | A Clinical Study Evaluating the Safety and Efficacy of SI-614 Ophthalmic Solution in Patients With Dry Eye. | July 2014 | |
| NCT02229955 | Completed | Phase 3 | Study of Tisporin Eye Drops Group and Restasis Eye Drops Group After Treatment, Each Treatment Group Comparisons for Evaluation of Efficacy and Safety in Moderate to Severe Dry Eye Disease | December 2013 | July 2014 |
| NCT02252744 | Completed | Prevalence of Dry Eye Disease in Patients Diagnosed With Rheumatoid Arthritis | November 2012 | December 2014 | |
| NCT02280473 | Completed | Phase 3 | A Safety and Efficacy Study of Refresh Optive® Gel Drops in Patients With Dry Eye Disease | November 13, 2014 | March 16, 2015 |
| NCT02298881 | Completed | Ocular Surface Microbiome | July 2013 | May 1, 2021 | |
| NCT02313454 | Completed | N/A | Evaluation of the Safety and Effectiveness of the Oculeve Intranasal Lacrimal Neurostimulator in Patients With Dry Eye | November 17, 2014 | April 8, 2015 |
| NCT02356328 | Completed | NovaTears® Eye Drops Observational Study NT-003 | January 2015 | January 2016 | |
| NCT02356341 | Completed | NovaTears® Eye Drops Observational Study NT-002 | January 2015 | December 2015 | |
| NCT02385292 | Completed | N/A | Multicenter Trial Evaluating Quality of Tears Produced by Nasal Neurostimulation | May 31, 2015 | March 31, 2016 |
| NCT02403219 | Completed | Phase 1 | Paralysis of the Orbicularis Muscle of the Eye in the Treatment for Dry Eye | May 2013 | January 2015 |
| NCT02420730 | Completed | Phase 1 | Safety, Tolerability and Systemic Pharmacokinetics of AGN-232411 in Healthy Participants and Participants With Dry Eye | June 2015 | March 2016 |
| NCT02435914 | Completed | Phase 2 | Safety, Efficacy, Tolerability and Pharmacokinetics of AGN-223575 Ophthalmic Suspension in Patients With Dry Eye Disease | June 2015 | January 2016 |
| NCT02455050 | Completed | Phase 3 | A Study to Compare a New Eye Drop Formulation With Systane® Gel Drops and Genteal® Lubricant Gel Drops for Moderate to Severe Dry Eye Relief | December 2014 | August 2015 |
| NCT02461719 | Completed | Phase 3 | Efficacy and Safety Study of TJCS for Treatment of Moderate to Severe Dry Eye Syndromes | January 2014 | October 2014 |
| NCT06174064 | Not yet recruiting | N/A | BroadBand Light for the Treatment of Dry Eye Disease | February 1, 2024 | August 30, 2025 |
| NCT06163989 | Not yet recruiting | N/A | Protecting the Eyes of Gamers With Lubricating Eyedrops | May 1, 2024 | August 31, 2024 |
| NCT06371300 | Not yet recruiting | N/A | Photobiomodulation With REd vs BluE Light (REBEL) | April 2024 | December 2025 |
| NCT06089317 | Not yet recruiting | N/A | Traditional Chinese Medicine Ultrasonic Atomization Treatment for Dry Eye Disease | March 1, 2024 | November 30, 2025 |
| NCT06379685 | Not yet recruiting | Phase 1 | Study to Evaluate the Safety and Tolerability of PRO-190 Ophthalmic Solution Compared to Systane Ultra® on the Ocular Surface. | September 30, 2024 | April 30, 2025 |
| NCT06388070 | Not yet recruiting | Phase 3 | To Evaluate the Efficacy and Safety of HUC3-053 in Patients With Dry Eye Syndrome | April 2024 | April 2025 |
| NCT05784519 | Not yet recruiting | Early Phase 1 | Therapeutic Effect of Stem Cell Eye Drops on Dry Eye Disease | June 1, 2023 | July 31, 2025 |
| NCT05121493 | Not yet recruiting | N/A | Study of Platelet Rich Plasma Drops to Moderate Clinically Significant Dry Eye | May 15, 2024 | May 15, 2026 |
| NCT05990712 | Not yet recruiting | Phase 4 | The Effect of a Pre-cataract Surgical Ocular Hygiene Regime on Microbial Load, Tear Osmolarity, Dry Eye, and Inflammatory Markers | September 1, 2023 | January 1, 2024 |
| NCT06351410 | Not yet recruiting | N/A | Assessment of Tear Production, Corneal Staining, and Comfort Level Wearing Different Types of Contact Lenses | May 2, 2024 | February 28, 2025 |
| NCT06317922 | Recruiting | N/A | Evaluation of Dry Eye Disease's Signs in Patients Who Were Administered Intravitreal Anti-VEGF Injections | February 5, 2024 | May 12, 2025 |
| NCT05598437 | Recruiting | Prevalence of Different Etiologies of Ocular Dryness in Patients Previously Diagnosed With Dry Eye Disease in A Sample of Egyptian Patients | November 1, 2022 | April 30, 2023 | |
| NCT06188260 | Recruiting | Phase 2 | Efficacy of a New Nanoemulsion Artificial Tear in Dry Eye Disease Management | November 13, 2023 | November 13, 2024 |
| NCT05618470 | Recruiting | Phase 2/Phase 3 | Wumeiwan Jiawei Fang Use in Patients With Blepharospasm | January 12, 2018 | September 30, 2024 |
| NCT06291194 | Recruiting | Phase 3 | Efficacy and Safety of AJU-S56 5% in Dry Eye Syndrome Patients | November 10, 2023 | May 2024 |
| NCT05653921 | Recruiting | Prospective Study to Validate the Imaging Biomarker for NCP (R33) | December 16, 2022 | July 14, 2025 | |
| NCT05741398 | Recruiting | N/A | Evaluation of Optical System in the Treatment of - Dry Eye Disease | June 1, 2023 | December 30, 2023 |
| NCT03358979 | Recruiting | Three-dimensional Analysis of EMMPRIN on Conjunctival Epithelial Cells Surface in Severe Dry Eye Syndrome (ALTESSE) | December 14, 2017 | March 2026 | |
| NCT06174181 | Recruiting | N/A | Preventive TREatment of Dry Eye in Patients Receiving Repeated Intravitreal Injections for Age-related Macular Degeneration | October 9, 2023 | October 9, 2025 |
| NCT06262100 | Recruiting | N/A | Lubricating Effectiveness of Carragelose Eye Drops in Patients Affected by Mild to Moderate Dry Eye | January 15, 2024 | December 15, 2024 |
| NCT06004895 | Recruiting | N/A | Mechanisms of Light-based Therapies for Dry Eye Disease | October 25, 2023 | October 2025 |
| NCT03135327 | Recruiting | N/A | Clinical Applications of Advanced Ophthalmic Imaging | January 1, 2007 | December 31, 2025 |
| NCT06220474 | Recruiting | N/A | Therapeutic Efficacy and Safety of Non-Invasive RF Treatment in Refractory MGD | July 1, 2024 | July 31, 2025 |
| NCT04730336 | Recruiting | N/A | Assessing the Impact of Tixel Treatment of Periorbital Wrinkles on Dry Eye Symptoms and Signs | August 9, 2019 | October 31, 2023 |
| NCT04685109 | Recruiting | N/A | 3 Month Study of Alocross Versus Vismed in Adults With Dry Eye Disease Related to Keratitis or Keratoconjunctivitis | May 11, 2021 | December 31, 2024 |
| NCT04701086 | Recruiting | N/A | 3 Month Study of Cationorm Pro Versus Vismed in Adults With Dry Eye Disease Related to Keratitis or Keratoconjunctivitis | September 30, 2021 | December 31, 2024 |
| NCT05825976 | Recruiting | N/A | Omega-3 Fatty Acid Supplementation and Tear Film Quality in Celiac Patients | March 25, 2023 | August 1, 2023 |
| NCT06406933 | Recruiting | Salivary Conductivity Screening for Primary Sjögren's Syndrome | July 1, 2023 | March 31, 2026 | |
| NCT06209879 | Recruiting | Phase 4 | Dual-Polymer Hydroxypropyl Guar-and Hyaluronic Acid Lubricants in Rheumatoid Arthritis | February 5, 2024 | December 2024 |
| NCT05887336 | Recruiting | N/A | Intra-Nasal Mechanical Stimulation (INMEST) as a Treatment Method for the Relief of Symptoms of Dry Eye | June 2023 | June 2024 |
| NCT05992922 | Recruiting | Phase 2 | A Study to Assess the Safety and Efficacy of IC265 Ophthalmic Solution for Dry Eye in Adult Participants | October 18, 2023 | April 2024 |
| NCT05945069 | Recruiting | N/A | Feasibility of Dynamic Muscle Stimulation + Radiofrequency for Improving Blink Quality in Subjects With Dry Eye Disease | August 1, 2023 | February 15, 2024 |
| NCT06427031 | Recruiting | Phase 3 | Comparing Efficacy and Safety of TJO-083 in Dry Eye Diseases Patients | July 14, 2023 | March 1, 2025 |
| NCT05469932 | Recruiting | N/A | Quantum Molecular Resonance Effects on Patients With Dry Eye Disease | February 14, 2021 | December 2022 |
| NCT06364943 | Recruiting | N/A | Tear Ferning Test for Dry Eye Diagnosis | April 5, 2024 | April 4, 2025 |
| NCT03827564 | Terminated | N/A | Goblet Cell Degranulation Produced by Intranasal Tear Neurostimulator (ITN) in Dry Eye Disease | June 24, 2019 | June 8, 2020 |
| NCT02031172 | Terminated | Effects of Sustained Reading on the Ocular Surface | March 2014 | June 2016 | |
| NCT04015219 | Terminated | N/A | Management of Signs and Symptoms Associated With Dry Eye Disease | July 18, 2018 | October 5, 2020 |
| NCT04143841 | Terminated | N/A | Viveye Ocular Magnetic Neurostimulation System (OMNS) for the Management of Severe Dry Eye Disease | October 30, 2019 | January 6, 2021 |
| NCT04260893 | Terminated | N/A | Prospective Study To Assess The Safety And Effectiveness Of Tixel Treatment On Dry Eye Symptoms In Asian Patients | January 23, 2020 | March 13, 2021 |
| NCT04413253 | Terminated | Phase 4 | Xiidra vs. Xiidra + Dextenza Treatment for Dry Eye Disease | August 1, 2020 | April 11, 2022 |
| NCT01072526 | Terminated | Phase 2 | Pilot Study of a Homeopathic Therapy in Combination With Cyclosporin (Restasis) in the Treatment of Dry Eye Disease | December 2007 | August 2010 |
| NCT02815293 | Terminated | Phase 3 | Topical Ophthalmic AGN-195263 for the Treatment of Evaporative Dry Eye | September 30, 2016 | June 21, 2017 |
| NCT02965846 | Terminated | Phase 3 | Topical Ophthalmic AGN-195263 for the Treatment of Evaporative Dry Eye | December 13, 2016 | June 13, 2017 |
| NCT03274999 | Terminated | N/A | Clinical Study to Evaluate Tear Characteristics Following Acute TrueTear™ Use | October 18, 2017 | November 9, 2017 |
| NCT03296111 | Terminated | Patients With Ocular Neuropathic Pain: Description of Pain and Impact on Their Quality of Life | May 4, 2017 | October 28, 2019 | |
| NCT03502447 | Terminated | N/A | Randomized Study of the Safety and Effectiveness of the TearCare System for the Signs and Symptoms of Dry Eye Disease | April 20, 2018 | January 2, 2019 |
| NCT02013791 | Terminated | Phase 2 | Phase 2 Study of a New Ophthalmic Formulation of Cyclosporine (Restasis® X) in Patients With Dry Eye Disease | April 29, 2014 | April 12, 2017 |
| NCT02767258 | Unknown status | N/A | Effect of Nursing Care on Prevention of Dry Eye | May 1, 2016 | December 31, 2019 |
| NCT04485533 | Unknown status | N/A | Clinical Investigation to Assess the Efficacy and the Safety of VisuXL® Gel Administered in Patients Affected by Moderate DED | July 6, 2020 | April 30, 2021 |
| NCT04744805 | Unknown status | Mask-associated Dry Eye Symptoms in China | January 29, 2021 | February 6, 2021 | |
| NCT04785261 | Unknown status | Phase 2 | Effect of Traditional Chinese Medicine on Basic Tear Secretion and Tear Cytokines in Patients With Dry Eye Disease | March 16, 2021 | May 31, 2022 |
| NCT04425551 | Unknown status | N/A | Effect of Micropulse Laser on Dry Eye Disease Due to Meibomian Gland Dysfunction | September 5, 2019 | February 2021 |
| NCT03140111 | Unknown status | N/A | LAMELLEYE for the Treatment of Dry Eye Symptoms in pSS Patients | October 16, 2017 | March 30, 2018 |
| NCT04806256 | Unknown status | N/A | CDSS of Traditional Chinese Medicine Intervention for Dry Eye Syndrome | July 11, 2020 | December 2022 |
| NCT03162497 | Unknown status | Phase 4 | Effect of Topical Azithromycin on Tear Film Thickness in Patients With Meibomian Gland Dysfunction | January 8, 2018 | August 31, 2023 |
| NCT02595606 | Unknown status | Phase 4 | 0.3% Sodium Hyaluronate in the Treatment of Dry Eye of Diabetic Patients | September 2015 | March 2016 |
| NCT04863742 | Unknown status | Phase 4 | Evaluation Of Vision Recovery And Comfort Index In Patients With Borderline/Mild Dry Eyes Undergoing FLACS With Premium IOL | April 26, 2021 | September 30, 2021 |
| NCT00797030 | Unknown status | Phase 4 | Topical Cyclosporine for the Treatment of Dry Eye in Patients Infected With the Human Immunodeficiency Virus | October 2006 | November 2008 |
| NCT05346783 | Unknown status | Phase 1/Phase 2 | Comparing Efficacy and Safety of TJO-083 in Dry Eye Disease Patients | October 14, 2021 | June 2023 |
| NCT03804502 | Unknown status | N/A | Pilot Study of TearCare System - Long-Term Extension | December 17, 2018 | July 2019 |
| NCT02585414 | Unknown status | Assessment of TFT by OCT in Healthy Subjects and Subjects With DES | August 31, 2017 | December 2023 | |
| NCT04608084 | Unknown status | Phase 4 | Platelet Rich Plasma Eye Drops for Treatment of Ocular Surface Disease | January 2021 | January 2023 |
| NCT03747614 | Unknown status | Phase 4 | Ocular Micro-vascular Research Base on Functional Slip Lamp Biomicroscopy | June 30, 2017 | June 30, 2020 |
| NCT04679883 | Unknown status | Phase 2 | Phase 2 Clinical Trial to Evaluate the Efficacy and Safety of GLH8NDE in Patients With Dry Eye Disease | April 1, 2021 | April 30, 2022 |
| NCT02782260 | Unknown status | Phase 2 | Assessment of the Efficacy of Ocular Dipyridamole in the Treatment of Dry Eye Symptomology in Subjects With Pterygium | July 2016 | January 2018 |
| NCT02533154 | Unknown status | Phase 4 | Effect of Benzalkonium Chloride Containing Eye Drops on the Conjunctival Bacterial Flora of Dry Eye Patients | July 27, 2015 | October 2023 |
| NCT04217785 | Unknown status | Phase 1/Phase 2 | Umbilical Cord Serum Versus Conventional Eyedrops | January 20, 2020 | May 2021 |
| NCT03395431 | Unknown status | N/A | Fingerprick Autologous Blood (FAB) in Severe Dry Eye Disease (DED) | February 2018 | July 2019 |
| NCT03399292 | Unknown status | Effect of Lipid Based Eye Drops on Tear Film Lipid Layer Thickness | April 12, 2017 | September 2, 2023 | |
| NCT05096546 | Unknown status | The Proportion of Patients Diagnosed With Dry Eye by the Asia Dry Eye Society (ADES) Criteria in Taiwan (DECS-TW) | October 21, 2021 | July 31, 2022 | |
| NCT05414799 | Unknown status | N/A | Effect of Exercises on Computer Vision Syndrome | May 11, 2022 | June 12, 2022 |
| NCT04000789 | Unknown status | N/A | The Effect of Combination of Vitamin A, Vitamin E, Sodium Hyaluronate 0.15% Eye Drop Compared With Sodium Hyaluronate 0.1% Eye Drop to Tear Film Stability and Conjunctival Goblet Cells Density in Patient With Non-Proliferative Diabetic Retinopathy (NPDR), and Proliferative Diabetic Retinopathy (PDR) | July 2019 | December 2019 |
| NCT05148507 | Unknown status | N/A | Optimization of the Ocular Surface Prior to Cataract Surgery Using PROKERA | November 4, 2021 | June 4, 2022 |
| NCT05433428 | Unknown status | Phase 4 | Metabolomic Profile in Dry Eye Syndrome Patients. | August 3, 2020 | May 23, 2023 |
| NCT05201170 | Unknown status | Phase 3 | A Phase 3, Multi-Center Study Evaluating PL9643 in Patients With Dry Eye | December 30, 2021 | December 31, 2022 |
| NCT01382810 | Unknown status | Phase 4 | Altaire Gel Forming Solution Versus Refresh Tears for the Treatment of Dry Eye Signs and Symptoms | March 2011 | October 2012 |
| NCT05429229 | Unknown status | Phase 2 | Effect of Topical Antioxidants in Dry Eye Disease and Diabetic Retinopathy | November 1, 2021 | January 31, 2024 |
| NCT02072122 | Unknown status | Estrogen and the Outer Eye in Women During Fertility Treatment | March 2014 | July 2014 | |
| NCT05304650 | Unknown status | Phase 4 | A Usability Study of External Neuromodulation With iTEAR100 Generation 2 | March 1, 2022 | June 15, 2022 |
| NCT03731624 | Unknown status | Diadenosine Polyphosphates and Mucin Associated With Ocular Surface Disorders | January 1, 2018 | December 31, 2023 | |
| NCT04668118 | Unknown status | Phase 4 | The Effect of 3% Diquafosol Ophthalmic Solution on Visual Display Terminal-associated Dry Eye | February 1, 2021 | March 25, 2023 |
| NCT04391907 | Withdrawn | N/A | Clinical Efficacy of Intense Pulsed Light(IPL) Procedure in Dry Eye Patient | March 3, 2020 | March 2, 2021 |
| NCT01364311 | Withdrawn | N/A | Treatment of Dry Eye With Supplements | July 2011 | November 2014 |
| NCT03952481 | Withdrawn | Phase 4 | Effect of Lifitegrast 5% on Tear Film Markers | March 1, 2021 | December 31, 2021 |
| NCT03396809 | Withdrawn | N/A | Punctal Plugs and Iodine Related Discomfort | July 26, 2017 | December 7, 2018 |
- MeSH unique ID (MeSH (Medical Subject Headings))
- D015352