squamous cell carcinoma (Cancer)
Information
- Disease name
- squamous cell carcinoma
- Disease ID
- DOID:1749
- Description
- "A carcinoma that derives_from squamous epithelial cells." [url:http\://en.wikipedia.org/wiki/Squamous_cell_carcinoma]
Disease area statistics
Chromosome band
| Gene symbol | Chromosome | Start | Stop | The number of variant |
|---|---|---|---|---|
| TP53 | 17 | 7,668,421 | 7,687,490 | 8 |
| KMT2D | 12 | 49,018,978 | 49,060,794 | 4 |
| CTLA4 | 2 | 203,867,771 | 203,873,965 | 2 |
| BRCA2 | 13 | 32,315,508 | 32,400,268 | 2 |
| BIRC3 | 11 | 102,317,484 | 102,339,403 | 2 |
| ZFHX3 | 16 | 72,782,885 | 73,891,871 | 2 |
| YAP1 | 11 | 102,110,461 | 102,233,423 | 2 |
| RAD50 | 5 | 132,556,977 | 132,646,349 | 2 |
| NF1 | 17 | 31,094,977 | 31,377,675 | 2 |
| CSF1R | 5 | 150,053,291 | 150,113,372 | 2 |
Annotation
| Genes | Mutation | Description | Source | Links |
|---|
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT01976468 | Active, not recruiting | Metastases of Cutaneous Squamous Cell Carcinoma in Organ Transplant Recipients. The "SCOPE-ITSCC Metastases Study" | November 2013 | January 2025 | |
| NCT05863052 | Active, not recruiting | Analyzing Clinical Outcomes and Genomic Data of American Indian Patient Population | January 31, 2022 | July 2026 | |
| NCT05883007 | Active, not recruiting | Phase 1 | Dose Optimized BNCT for Head and Neck Cancer | June 1, 2020 | May 31, 2024 |
| NCT06046625 | Active, not recruiting | Needs and Preferences of Patients With Head-neck Cutaneous SCC | November 1, 2021 | November 30, 2023 | |
| NCT05202860 | Active, not recruiting | Phase 2 | Impact of Human Papillomavirus (HPV) Vaccination on Burden of Disease in Patients With Actinic Keratosis | May 9, 2022 | June 2035 |
| NCT03854032 | Active, not recruiting | Phase 2 | Nivolumab and BMS986205 in Treating Patients With Stage II-IV Squamous Cell Cancer of the Head and Neck | April 9, 2019 | December 2025 |
| NCT03729518 | Active, not recruiting | N/A | TORS De-Intensification Protocol Version 2.0: Dose and Volume Reduction in the Neck | October 11, 2018 | October 11, 2024 |
| NCT04150900 | Active, not recruiting | Phase 2 | 1922GCCC: Pembro and Bavituximab for Squamous Cell Carcinoma of Head and Neck | January 13, 2020 | January 1, 2027 |
| NCT05610293 | Active, not recruiting | T1 Squamous Cell Carcinomas of the Lip | April 1, 2021 | November 1, 2023 | |
| NCT03719924 | Active, not recruiting | Phase 2 | Nal-iri/lv5-fu Versus Paclitaxel as Second Line Therapy in Patients With Metastatic Oesophageal Squamous Cell Carcinoma | March 7, 2019 | April 15, 2025 |
| NCT03494322 | Active, not recruiting | Phase 2 | EACH: Evaluating Avelumab in Combination With Cetuximab in Head and Neck Cancer | July 20, 2018 | October 31, 2024 |
| NCT03982212 | Active, not recruiting | Phase 1 | A Window of Opportunity Trial of Intratumoral Injection of Copaxone® in Patients With Percutaneously Accessible Tumors | July 26, 2019 | July 2024 |
| NCT03476330 | Active, not recruiting | Phase 2 | Quercetin Chemoprevention for Squamous Cell Carcinoma in Patients With Fanconi Anemia | May 8, 2018 | October 2026 |
| NCT03387111 | Active, not recruiting | Phase 1/Phase 2 | QUILT-3.090: NANT Squamous Cell Carcinoma (SCC) Vaccine: Subjects With SCC Who Have Progressed | January 13, 2018 | April 2021 |
| NCT03381183 | Active, not recruiting | Phase 1 | IRX-2 Regimen and Durvalumab, for Incurable H&N Squamous Cell Carcinoma | August 21, 2019 | December 2024 |
| NCT02586207 | Active, not recruiting | Phase 1 | Pembrolizumab in Combination With CRT for LA-SCCHN | November 2015 | September 2024 |
| NCT05019235 | Active, not recruiting | Study of the Association Between Tumor Microenvironment Macrophages and Treatment Response in Squamous Cell Carcinoma of the Anal Canal | August 5, 2021 | April 30, 2023 | |
| NCT04808999 | Active, not recruiting | Phase 2 | Neoadjuvant Study of PD-1 Inhibitor Pembrolizumab in PD-1 Naive Cutaneous Squamous Cell Carcinoma (cSCC) | May 28, 2021 | April 30, 2029 |
| NCT05987579 | Active, not recruiting | Surgical Treatment of Stage T3 Squamous Cell Carcinomas of the Scalp | May 3, 2021 | December 1, 2024 | |
| NCT02131805 | Active, not recruiting | N/A | Electronic Skin Surface Brachytherapy for Cutaneous Basal Cell and Squamous Cell Carcinoma | May 2014 | May 2025 |
| NCT01586767 | Active, not recruiting | N/A | Intensity-Modulated or Proton Radiation Therapy for Sinonasal Malignancy | July 12, 2011 | November 2025 |
| NCT06227416 | Active, not recruiting | N/A | Skin Tumor Biomarkers by Mass Spectrometry Imaging | June 15, 2020 | May 31, 2025 |
| NCT04681248 | Available | Expanded Access Use of DKN-01 for the Treatment of Advanced Solid Tumors | |||
| NCT05974410 | Available | Expanded Access to Immunomodulatory AVM0703 for Solid Tumor and Blood Cancer Patients | |||
| NCT00578214 | Completed | N/A | Safety and Efficacy of Oral Midazolam for Perioperative Anxiety Relief of Patients Undergoing Mohs Micrographic Surgery | March 2007 | June 2008 |
| NCT00581815 | Completed | Phase 1 | Spectroscopy With Surface Coils and Decoupling | February 1997 | February 2014 |
| NCT00586040 | Completed | Phase 2 | Photochemical Tissue Bonding | September 2007 | April 2009 |
| NCT00596219 | Completed | N/A | Molecular Effects of Short-Term Celecoxib Treatment on Head and Neck Squamous Cell Carcinoma | December 2003 | October 2010 |
| NCT00601185 | Completed | Confocal Reflectance Microscopy of Shave-Biopsy Sites on Skin in Vivo. | February 14, 2006 | February 23, 2018 | |
| NCT00652080 | Completed | Phase 1/Phase 2 | An Open-Label Safety Study of API 31510 in a Topical Cream for in Situ Cutaneous Squamous Cell Carcinoma (SCCIS) | June 2008 | January 2010 |
| NCT00765193 | Completed | N/A | The Impact of Total Body Skin Examination on Skin Cancer Detection | May 2008 | May 2009 |
| NCT00770393 | Completed | Phase 2/Phase 3 | Laryngeal Preservation in Pyriform Sinus Carcinoma | February 2002 | June 2007 |
| NCT00793169 | Completed | Serum Concentration of Lidocaine After Local Injection During Mohs Micrographic Surgery | September 2007 | July 2008 | |
| NCT00836342 | Completed | Correlation Between Skin Carotenoid Levels and Previous History of Skin Cancer | February 2009 | January 2012 | |
| NCT00878995 | Completed | Phase 1 | Testosterone for Treating Cachexia in Patients With Squamous Cell Carcinoma | June 3, 2009 | June 2015 |
| NCT00884520 | Completed | Early Phase 1 | An Exploratory, Open Label, Multi-Center, Non-Randomized Study of [F-18]VM4-037 | April 2009 | March 2010 |
| NCT00895349 | Completed | N/A | Impact of Positron Emission Tomography (PET) Imaging in Women With Locally Advanced Cervical Cancer (PET LACE Trial) | April 2010 | August 2019 |
| NCT00966472 | Completed | Phase 1 | Phase I Study of a Statin + Erlotinib for Advanced Solid Malignancies With Focus on Squamous Cell Carcinomas and NSCLC | March 2009 | September 2014 |
| NCT01016899 | Completed | Electronic Brachytherapy for the Treatment of NMSC | August 2009 | August 2013 | |
| NCT01020097 | Completed | N/A | Fluorine F 18 EF5 Positron Emission Tomography in Assessing Hypoxia in Patients With Newly Diagnosed Stage I, Stage II, Stage III, or Stage IV Head or Neck Squamous Cell Cancer of the Oral Cavity, Oropharynx, and Larynx | March 2009 | December 2013 |
| NCT01043328 | Completed | Human Papillomavirus on Oral Tissue, Saliva and Serum | May 2009 | December 2010 | |
| NCT01077817 | Completed | Observational Study of Incidence Rates of Esophageal Cancer in Women Taking Medications for the Prevention or Treatment of Osteoporosis (MK-0217A-352) | February 26, 2010 | February 16, 2012 | |
| NCT01077999 | Completed | Phase 2 | Chemoradiation and Panitumumab for Esophageal Cancer | January 2010 | April 2012 |
| NCT01089803 | Completed | Observational Study of Swallowing Function After Treatment of Advanced Laryngeal Cancer | September 2009 | August 2015 | |
| NCT01115790 | Completed | Phase 1 | A Phase 1 Study in Participants With Advanced Cancer | February 2010 | January 2016 |
| NCT01127737 | Completed | N/A | Warning Signs of Squamous Cell Carcinoma and Prevention of SCC by at Risk Organ Transplant Recipients | September 2007 | April 2011 |
| NCT01133665 | Completed | Phase 2 | Cetuximab and Lenalidomide in Head and Neck | February 2010 | August 2012 |
| NCT01135823 | Completed | Symptom Assessment With Patient Surveys | July 2006 | June 2008 | |
| NCT01208883 | Completed | Phase 1 | A Feasibility Study On Continuous Adaptive [18f]Fdg-Pet-Guided Radiotherapy For Head and Neck Cancer | September 2010 | March 2012 |
| NCT01211938 | Completed | Phase 2/Phase 3 | Trial Comparing Two Protocols of re Irradiation in an Irradiated Area for Carcinoma of the Upper Aerodigestive Tract | June 15, 2010 | February 25, 2017 |
| NCT01298167 | Completed | N/A | Absorbable Suture Versus Tissue Glue to Repair Defects Following Mohs Surgery | February 2011 | August 2012 |
| NCT01526486 | Completed | N/A | Videoscopic Versus Open Inguinal Lymphadenectomy for Cancer | June 2009 | February 2013 |
| NCT01540695 | Completed | Does Cryofixation of Skin Specimens Affect Quality of Subsequent Formalin Fixed Paraffin Embedded H and E Histology | February 2012 | January 2013 | |
| NCT01561456 | Completed | Phase 2 | Study of AXL1717 Compared to Docetaxel to Treat Squamous Cell Carcinoma or Adenocarcinoma of the Lung | December 2011 | December 2013 |
| NCT01592721 | Completed | Phase 1/Phase 2 | Radiation and Cetuximab Plus Intratumoral EGFR Antisense DNA in Locally Advanced Head and Neck Squamous Cell Carcinoma | April 2013 | February 1, 2022 |
| NCT01631357 | Completed | Phase 2/Phase 3 | Study of Chemotherapy Combination With Autologous Cytokine-Induced Killer Cell Immunotherapy to Treat Lung Cancer | December 2014 | December 2018 |
| NCT00001442 | Completed | Phase 1 | A Pilot Study of Paclitaxel With Radiation Therapy for Locally Advanced Head and Neck Cancer | July 1995 | June 2004 |
| NCT00001603 | Completed | The Effects of Upper Airway and Digestive Tract Tumors on the Immune System | December 1996 | December 2004 | |
| NCT00011778 | Completed | Phase 1 | PS-341 and Radiation to Treat Advanced Cancer of the Head and Neck | February 22, 2001 | February 8, 2013 |
| NCT00046189 | Completed | Cancer Risk in Carriers of the Gene for Xeroderma Pigmentosum | April 7, 2003 | January 5, 2024 | |
| NCT00073398 | Completed | Phase 1/Phase 2 | Vaccine Treatment for Advanced Non-Small Cell Lung Cancer | November 2003 | March 2013 |
| NCT00101582 | Completed | Phase 3 | Palifermin for the Reduction of Oral Mucositis in Patients With Locally Advanced Head and Neck Cancer | August 2005 | August 2016 |
| NCT00139230 | Completed | Phase 2 | Combination Chemotherapy for Locally Advanced Squamous Cell Carcinoma of the Head and Neck | January 1997 | December 2006 |
| NCT00139243 | Completed | Phase 1/Phase 2 | Study of Taxotere, Cisplatin, 5-Fluorouracil, and Leucovorin for Squamous Cell Carcinoma of the Head and Neck | October 1997 | January 2006 |
| NCT00176254 | Completed | Phase 2 | Paclitaxel, Carboplatin and Radiotherapy as Induction Therapy in Locally Advanced Head and Neck Cancer | May 2000 | October 2012 |
| NCT00176267 | Completed | Phase 2 | Paclitaxel, Carboplatin And Low Dose Radiation As Induction Therapy In Locally Advanced Head And Neck Cancer | September 2002 | January 31, 2017 |
| NCT00195299 | Completed | Study Evaluating Temsirolimus in Advanced Stage Squamous Cell Carcinoma of the Head & Neck | April 2005 | February 2007 | |
| NCT00197444 | Completed | Phase 2 | Low-Dose Nedaplatin (CDGP:Cis-Diammine-Glycolatoplatinum)/5-FU Combined With Radiation for Esophageal Cancer | January 2003 | December 2008 |
| NCT00201279 | Completed | Phase 3 | Chemoprevention Study of Oral Cavity Squamous Cell Carcinoma | April 1999 | September 2012 |
| NCT00201383 | Completed | Phase 3 | Post-Operative Adjuvant Concurrent Chemoradiotherapy For High Risk Oral Cavity Squamous Cell Carcinoma Patients | October 1999 | August 2009 |
| NCT00364715 | Completed | Study the Expression of Annexin A1 and Its Potential Usage as a Prognostic Marker in Oral Cancer | January 2005 | December 2005 | |
| NCT00374062 | Completed | N/A | Effect of the Subconscious on Mohs Micrographic Surgery | December 2007 | August 2009 |
| NCT00409565 | Completed | Phase 2 | A Phase II Trial of Cetuximab and Bevacizumab in Patients With Recurrent or Metastatic Head and Neck Cancer | September 2006 | February 2012 |
| NCT00446446 | Completed | Phase 2 | PRISM (Panitumumab Regimen In Second-line Monotherapy of Head and Neck Cancer) | October 30, 2007 | November 29, 2017 |
| NCT00472459 | Completed | Phase 3 | PDT With Metvix® 160 mg/g Cream in Organ Transplant Recipients With Non-melanoma Skin Cancer | July 2003 | July 2006 |
| NCT00476476 | Completed | Phase 2 | Erlotinib in Women With Squamous Cell Carcinoma of the Vulvar | December 2006 | October 2012 |
| NCT00500760 | Completed | Phase 2 | Study of Addition of Panitumumab to Chemoradiation Therapy in Patients With Locally Advanced Head and Neck Cancer | October 1, 2007 | April 26, 2011 |
| NCT00540566 | Completed | Optical Biopsy of Human Skin in Conjunction With Laser Treatment | June 1999 | July 2008 | |
| NCT00547157 | Completed | Phase 2 | Radiotherapy Plus Panitumumab Compared to Chemoradiotherapy With Unresected, Locally Advanced Squamous Cell Carcinoma of the Head and Neck | November 2007 | March 2012 |
| NCT00574392 | Completed | Multi-Wavelength and Coherence Confocal Reflectance Microscopy of Pigmented and Non-Pigmented Lesions on the Skin In-Vivo | November 2006 | September 2013 | |
| NCT01770002 | Completed | N/A | Eversion in Dermatologic Surgery: Is Cosmetic Appearance Improved? | January 2012 | September 2014 |
| NCT01773447 | Completed | N/A | Set-back Suture Versus Traditional Vertical Mattress Suture | August 2011 | April 2014 |
| NCT01872130 | Completed | Reflectance Confocal Microscopy of Wounds During Moh's Surgery: Feasibility Testing of a Mosaicing Algorithm for Intraoperative Imaging of Cancer Margins | May 2013 | April 28, 2020 | |
| NCT01905891 | Completed | N/A | Nanocytology Test to Evaluate Skin Cancer in High Risk Patients | July 2013 | November 2014 |
| NCT02013154 | Completed | Phase 1 | A Study of DKN-01 in Combination With Paclitaxel or Pembrolizumab | May 5, 2014 | January 11, 2021 |
| NCT02088515 | Completed | Phase 4 | Nedaplatin (Jiebaishu®) Combined With Docetaxel for Advanced Lung Squamous Cell Carcinoma | December 2013 | February 2017 |
| NCT02095912 | Completed | Aggressive Squamous Cell Carcinoma in Organ Transplant Recipients | March 2014 | January 2016 | |
| NCT02151149 | Completed | Phase 4 | Safety and Efficacy Study of Abraxane in Combination With Carboplatin to Treat Advanced NSCL Cancer in the Elderly | June 9, 2014 | July 14, 2017 |
| NCT02370303 | Completed | A Study to Isolate and Test Circulating Tumor Cells Using the ClearCell® FX EP+ System | August 2014 | July 9, 2016 | |
| NCT02394652 | Completed | Phase 2 | The Potential for Metformin to Improve Tumor Oxygenation in Locally Advanced Cervix Cancer: A Phase II Randomized Trial | May 21, 2015 | January 12, 2021 |
| NCT02409628 | Completed | N/A | EktoTherix™ Regenerative Tissue Scaffold for Repair of Surgical Excision Wounds | April 23, 2015 | July 2017 |
| NCT02410603 | Completed | Isolating and Testing Circulating Tumor DNA and Soluble Immune Markers During the Course of Treatment for Lung Cancer | December 2016 | January 1, 2021 | |
| NCT02426879 | Completed | N/A | Esophagectomy for Patients With Esophageal Cancer and Cervical Lymph Node Metastases | February 11, 2015 | January 25, 2021 |
| NCT02580916 | Completed | N/A | Utility of the Skin Cancer Quality of Life Impact Tool | July 2015 | November 2017 |
| NCT02776137 | Completed | Phase 2 | Postoperative Concurrent Chemoradiotherapy With Docetaxel for High-Risk Squamous Cell Carcinoma of Head and Neck | March 2016 | February 2019 |
| NCT02902822 | Completed | N/A | Tele-dermatology of Skin Cancer in a Cohort of Local Health Authority Employees in the Province of Bergamo | October 2016 | May 2019 |
| NCT03015883 | Completed | N/A | Alpha Radiation Emitters Device for the Treatment of Squamous Cell Carcinoma | February 22, 2017 | June 25, 2019 |
| NCT03058289 | Completed | Phase 1/Phase 2 | A Phase 1/2 Safety Study of Intratumorally Dosed INT230-6 | February 9, 2017 | February 22, 2023 |
| NCT03162042 | Completed | Role of Myostatin, Activin A and Follistatin Cachexia of ENT Cancers | November 2, 2015 | May 2017 | |
| NCT03190174 | Completed | Phase 1/Phase 2 | Nivolumab (Opdivo®) Plus ABI-009 (Nab-rapamycin) for Advanced Sarcoma and Certain Cancers | August 24, 2017 | December 2, 2021 |
| NCT03215810 | Completed | Phase 1 | Nivolumab and Tumor Infiltrating Lymphocytes (TIL) in Advanced Non-Small Cell Lung Cancer | October 11, 2017 | June 9, 2023 |
| NCT03237013 | Completed | N/A | Strategies to Promote Skin Health | February 18, 2016 | January 14, 2017 |
| NCT03284424 | Completed | Phase 2 | Study of Pembrolizumab (MK-3475) in Adults With Recurrent/Metastatic Cutaneous Squamous Cell Carcinoma (cSCC) or Locally Advanced Unresectable cSCC (MK-3475-629/KEYNOTE-629) | October 26, 2017 | September 13, 2023 |
| NCT03342378 | Completed | PET-MRI Assessment of Early Tumor Response to Predict Outcomes of HPV-Positive Oropharynx Cancer Patients | May 3, 2018 | May 15, 2021 | |
| NCT03458117 | Completed | Phase 1 | T-VEC in Non-melanoma Skin Cancer | April 19, 2018 | March 15, 2022 |
| NCT03462524 | Completed | Neoadjuvant Therapy for Esophageal Cancer and Cardiopulmonary Physiology | January 1, 2010 | January 1, 2018 | |
| NCT03509467 | Completed | N/A | Using MC1R Genotype to Impact Melanoma Risk Behavior | August 3, 2015 | February 19, 2021 |
| NCT03641547 | Completed | Phase 1 | M6620 Plus Standard Treatment in Oesophageal and Other Cancer | December 4, 2018 | April 4, 2022 |
| NCT03714828 | Completed | Phase 2 | Study of TVEC in Patients With Cutaneous Squamous Cell Cancer | December 20, 2018 | July 19, 2023 |
| NCT03758781 | Completed | Phase 1 | IRX-2 Regimen Combined With Nivolumab in Recurrent/Metastatic Solid Tumors | February 13, 2019 | August 11, 2021 |
| NCT03769311 | Completed | Phase 2 | Cetuximab in Head and Neck Cancer Patients | April 17, 2019 | March 15, 2022 |
| NCT03841110 | Completed | Phase 1 | FT500 as Monotherapy and in Combination With Immune Checkpoint Inhibitors in Subjects With Advanced Solid Tumors | February 15, 2019 | November 15, 2022 |
| NCT04201002 | Completed | Surgery Plus Intraoperative Radiotherapy as Treatment for Squamous Cell Carcinoma Over Pilonidal Disease. | February 1, 2019 | November 1, 2019 | |
| NCT04260074 | Completed | Epigenetic Changes in Head and Neck Cancer | March 11, 2020 | July 14, 2021 | |
| NCT04606940 | Completed | Study of Circulating Tumor DNA (ctDNA) Kinetics in Immuno-oncology (IO-KIN) | October 19, 2020 | October 12, 2021 | |
| NCT04969419 | Completed | Incidence of Melanoma and Non-melanoma Skin Cancer in People With Vitiligo | June 18, 2021 | April 4, 2023 | |
| NCT05125354 | Completed | A Retrospective Analysis to Evaluate Long Term Outcomes of SCC Patients Previously Treated With Alpha DaRT | January 6, 2022 | March 6, 2022 | |
| NCT05126173 | Completed | DERM US and EU Validation Study | March 15, 2022 | September 15, 2022 | |
| NCT05337163 | Completed | A Multicenter Clinical Trial of Sputum DNA Testing for Lung Cancer in China | February 25, 2022 | August 29, 2023 | |
| NCT05941676 | Completed | Prognostic Immune Biomarkers in HNSCC | June 1, 2020 | June 30, 2023 | |
| NCT04814953 | Enrolling by invitation | HRQoL Keratinocyte Carcinomas | July 1, 2020 | December 31, 2025 | |
| NCT05929547 | Not yet recruiting | Patient Perspectives in Squamous Cell Carcinoma Clinical Trials | July 2024 | July 2026 | |
| NCT04595981 | Not yet recruiting | Phase 2 | Chemo-embolization for Head and Neck Cancer | May 2025 | January 2029 |
| NCT06418516 | Not yet recruiting | N/A | Early Detection of Esophageal Squamous Cancer With the Capsule Sponge Device | June 1, 2024 | June 1, 2027 |
| NCT05852665 | Not yet recruiting | N/A | Buccal Cancer Resection Ultrasound Guided | September 1, 2023 | March 1, 2026 |
| NCT05843032 | Not yet recruiting | N/A | 3D Ultrasound, Specimen Examination by Surgeon, and MRI in Surgical Margin Assessment | May 15, 2023 | February 15, 2024 |
| NCT06398418 | Not yet recruiting | Phase 1 | R-5780-01 In Combination With PD-1 Checkpoint Inhibitors (Checkpoint Protein on Immune Cells Called T Cells) in Patients With Solid Tumors | June 1, 2024 | September 30, 2026 |
| NCT06384924 | Not yet recruiting | Raman Spectroscopy and Skin Cancer | May 16, 2024 | April 30, 2025 | |
| NCT05065346 | Not yet recruiting | N/A | Neoadjuvant DaRT for Locally Advanced Oral Cavity SCC | March 2025 | June 2026 |
| NCT04889742 | Not yet recruiting | Phase 2 | Hyperthermia Enhanced Re-irradiation of Loco-regional Recurrent Tumors | May 10, 2024 | January 2028 |
| NCT05740774 | Recruiting | N/A | Surgical Margin Assessment by 3D Ultrasound | January 1, 2023 | April 30, 2023 |
| NCT05854030 | Recruiting | Serum Exosomal miRNA Predicting the Therapeutic Efficiency in Lung Squamous Carcinoma | April 1, 2022 | August 31, 2023 | |
| NCT05858229 | Recruiting | Phase 1/Phase 2 | Neo-adjuvant Treatment for Squamous Cell Carcinoma Using Direct Tumor Injection With RP1. | June 16, 2023 | June 2026 |
| NCT05932511 | Recruiting | Early Phase 1 | Topical Ascorbic Acid for Treatment of Squamous Cell Skin Cancer | June 12, 2023 | December 31, 2024 |
| NCT06450080 | Recruiting | N/A | Study of the Relationship Between Clinical, Imaging and Biological Data in Patients With Squamous Cell Carcinoma of the Tongue | March 27, 2024 | June 2026 |
| NCT03708224 | Recruiting | Phase 2 | Preoperative Immunotherapy in Patients With Squamous Cell Carcinoma of the Head and Neck | March 8, 2019 | June 30, 2027 |
| NCT06041802 | Recruiting | Phase 2 | A Study of MK-3475A (Pembrolizumab Formulated With MK-5180) in Japanese Participants With Recurrent or Metastatic Cutaneous Squamous Cell Carcinoma (R/M cSCC) or Locally Advanced (LA) Unresectable cSCC (MK-3475A-E39) | October 20, 2023 | March 2, 2027 |
| NCT03786237 | Recruiting | Phase 1/Phase 2 | Rigosertib for RDEB-SCC | April 12, 2021 | June 2026 |
| NCT03944915 | Recruiting | Phase 2 | De-Escalation Therapy for Human Papillomavirus Negative Disease | August 26, 2019 | July 1, 2024 |
| NCT06047379 | Recruiting | Phase 1/Phase 2 | Safety and Efficacy of NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Brain Metastasis | November 1, 2023 | August 31, 2026 |
| NCT04224389 | Recruiting | IMRT and Primary Transoral Surgery in the Treatment of Squamous Cell Carcinomas | June 22, 2018 | June 2026 | |
| NCT06137274 | Recruiting | N/A | Pilot Trial of Adaptive Radiotherapy Boost for HNSCC | December 18, 2023 | January 2027 |
| NCT04260802 | Recruiting | Phase 1/Phase 2 | A Study to Evaluate the Safety and Pharmacokinetics of OC-001 in Patients With Locally Advanced or Metastatic Cancers | October 6, 2020 | September 30, 2026 |
| NCT04370587 | Recruiting | Phase 1/Phase 2 | A Clinical Study of Intratumoral MVR-T3011 (T3011) Given as a Single Agent and in Combination With Intravenous Pembrolizumab in Participants With Advanced or Metastatic Solid Tumors | September 17, 2020 | October 31, 2025 |
| NCT04391049 | Recruiting | Phase 1 | Testing the Addition of the Anti-cancer Viral Therapy Telomelysin™ to Chemoradiation for Patients With Advanced Esophageal Cancer and Are Not Candidates for Surgery | June 29, 2020 | October 1, 2025 |
| NCT04475952 | Recruiting | Early Diagnosis of Upper Digestive Tract Disease | September 13, 2019 | September 13, 2024 | |
| NCT04738786 | Recruiting | N/A | Clinical Study Evaluating the Proper Surgical Safety Margin for Early Stage Oral Tongue Cancers | January 18, 2021 | December 31, 2030 |
| NCT04839731 | Recruiting | Early Phase 1 | Combination 5-FU / Calcipotriene Cream for SCCIS/SCC | April 14, 2021 | December 2023 |
| NCT06377735 | Recruiting | N/A | BAI-BACE for Advanced Lung Squamous Cell Carcinoma | May 1, 2024 | December 30, 2026 |
| NCT05007613 | Recruiting | Phase 2 | Second-line Cabozantinib and Atezolizumab in Patients With Recurrent or Metastatic Esophageal Squamous Cell Carcinoma | June 23, 2021 | June 23, 2023 |
| NCT05027633 | Recruiting | Phase 2 | Immunotherapy With Chemotherapy and Chemoradiation for Advanced Squamous Cancer of Nasal Cavity / Paranasal Sinuses (I-NAPA) | November 2, 2021 | March 30, 2026 |
| NCT05038657 | Recruiting | Phase 2 | Atezolizumab Immunotherapy, in Immunotherapy Naive Patients With Urinary Tract Squamous Cell Carcinoma (UTSCC). | May 30, 2022 | January 2025 |
| NCT05048459 | Recruiting | N/A | Comparing Two Surveillance Approaches for People Who Have Received Treatment for HPV-associated Head and Neck Cancer and Show No Signs of Disease | September 1, 2021 | September 2025 |
| NCT05070403 | Recruiting | Phase 2 | Study of Afatinib in Advanced Cutaneous Squamous Cell Carcinoma | October 1, 2021 | July 2028 |
| NCT05104619 | Recruiting | Spectroscopic Analysis of Tongue Tumor Samples. | October 1, 2021 | October 2023 | |
| NCT05108090 | Recruiting | N/A | Sentinel Lymph Node Biopsy for Cutaneous Squamous Cell Carcinoma of the Head and Neck | October 25, 2021 | September 2024 |
| NCT02128906 | Recruiting | Phase 2 | Radiotherapy With Cisplatin vs. Docetaxel-cetuximab in HNSCC: ERCC1 Biomarker Enrichment and Interaction Design | December 23, 2013 | December 2030 |
| NCT02133196 | Recruiting | Phase 2 | T Cell Receptor Immunotherapy for Patients With Metastatic Non-Small Cell Lung Cancer | October 23, 2014 | October 23, 2025 |
| NCT05574101 | Recruiting | Phase 2 | A Study of Radiation Therapy and Cemiplimab for People With Skin Cancer | October 6, 2022 | October 6, 2026 |
| NCT02549638 | Recruiting | Identification of Prognostic Biomarkers for Progression of Invasive Squamous Cell Carcinoma | August 2015 | August 2024 | |
| NCT05648604 | Recruiting | N/A | Mentored Community Gardening for Individuals With Skin Cancer | February 2, 2023 | December 30, 2024 |
| NCT05681039 | Recruiting | Phase 2 | Phase 2 Trial of Neoadjuvant and Adjuvant Tiragolumab Plus Atezolizumab in Patients With Newly Diagnosed PD-L1 CPS Positive Resectable Stage 3-4 Oral Cavity Squamous Cell Carcinoma (OCSCC). | June 2, 2023 | November 1, 2026 |
| NCT05693116 | Recruiting | Survival and Prognostic Factors of Squamous Cell Carcinoma of the Nasal Vestibule | December 1, 2022 | December 2029 | |
| NCT03952585 | Suspended | Phase 2/Phase 3 | De-intensified Radiation Therapy With Chemotherapy (Cisplatin) or Immunotherapy (Nivolumab) in Treating Patients With Early-Stage, HPV-Positive, Non-Smoking Associated Oropharyngeal Cancer | October 9, 2019 | February 28, 2025 |
| NCT02223975 | Suspended | Evaluation of the Role of Vibrational Spectroscopy in the Assessment of Vulval Disease | August 2014 | August 2018 | |
| NCT04714983 | Suspended | Phase 1 | DNX-2440 for Resectable Colorectal Liver Metastasis | February 15, 2021 | December 31, 2026 |
| NCT01755650 | Terminated | Early Phase 1 | Phase 0 of 18F FPM Using PET/CT in Patients With a Variety of Malignancies | October 2011 | November 3, 2017 |
| NCT04442126 | Terminated | Phase 1/Phase 2 | A Study of NM21-1480 in Adult Patients With Advanced Solid Tumors | August 19, 2020 | February 6, 2024 |
| NCT02059252 | Terminated | Phase 1/Phase 2 | Safety, Tolerability and Performance of SmartMatrix Dermal Replacement Scaffold | August 2014 | March 2016 |
| NCT00507702 | Terminated | Identification of Key Blood Molecular Markers for Immunotherapy | July 6, 2006 | February 25, 2015 | |
| NCT04685798 | Terminated | N/A | Optimized Diffusion-Weighted Imaging for the Evaluation of Post-Treatment Squamous Cell Carcinoma in the Neck: Comparative Study With FDG PET/CT | September 2, 2020 | September 26, 2023 |
| NCT04688749 | Terminated | Use of Electrical Impedance Spectroscopy (EIS) for Early Diagnosis of Skin Damage | July 17, 2019 | December 31, 2022 | |
| NCT04106167 | Terminated | Long-term, Non-interventional, Observational Study Following Treatment With Fate Therapeutics FT500 Cellular Immunotherapy | June 11, 2019 | August 11, 2023 | |
| NCT00707655 | Terminated | Phase 1/Phase 2 | Zalutumumab in Combination With Radiotherapy in Head and Neck Cancer Patients Ineligible for Platinum Based Chemotherapy | September 2008 | October 2010 |
| NCT00443261 | Terminated | Phase 1 | Azacitidine and Cisplatin for Patients With Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck | February 2007 | June 2008 |
| NCT02213133 | Terminated | Phase 2 | Selinexor Treatment of Advanced Relapsed/Refractory Squamous Cell Carcinomas | September 22, 2014 | December 10, 2015 |
| NCT01666431 | Terminated | Phase 2 | Single-center Investigator Initiated Pilot Study Investigating the Tumor Response of Squamous Cell Carcinoma Lesions in Patients Under Lapatinib Treatment | June 2012 | November 2013 |
| NCT00427102 | Terminated | Phase 1 | MRX, Radiation, and Chemotherapy for Patients With Resected Squamous Cell Carcinoma of the Head and Neck | January 2007 | July 2007 |
| NCT03223662 | Terminated | Phase 2 | Metabolomic and BH3 Profiling of Esophageal Cancers: Identification of Novel Assessment Methods of Treatment Response for Precision Therapy | October 31, 2017 | July 27, 2018 |
| NCT01161498 | Terminated | Phase 3 | Study of Safety and Efficacy of Talimogene Laherparepvec With Cisplatin and Radiotherapy for Treatment of Locally Advanced Head and Neck Cancer | February 2011 | October 2011 |
| NCT01363466 | Terminated | Phase 3 | Evaluation of Hysterectomy After Chemoradiation Therapy for Stage IB2/II Cervical Cancer | May 2003 | November 2006 |
| NCT04410874 | Terminated | Phase 1/Phase 2 | Imvamune Vaccine for the Treatment of Non-melanoma Skin Cancer | November 16, 2020 | May 23, 2023 |
| NCT01009203 | Terminated | Phase 2 | Temsirolimus (Torisel®) and Erlotinib (Tarceva®) in Platinum-Refractory/Ineligible, Advanced, Squamous Cell Carcinoma | December 2009 | December 2012 |
| NCT03875859 | Terminated | Phase 2 | Topical Remetinostat Gel as Neoadjuvant Therapy in Patients With Squamous Cell Carcinoma (SCC) | December 12, 2019 | January 30, 2021 |
| NCT00573131 | Terminated | Phase 2 | Efficacy and Safety of OncoGel™ Added to Chemotherapy and Radiation Before Surgery in Subjects With Esophageal Cancer | January 2008 | November 2010 |
| NCT03802058 | Terminated | Phase 2 | Concurrent Nab-P/Carboplatin and Thoracic Radiotherapy in Squamous Cell Lung Cancer | March 20, 2019 | December 12, 2021 |
| NCT01333852 | Terminated | Phase 2 | Metformin Plus Paclitaxel for Metastatic or Recurrent Head and Neck Cancer | February 2011 | April 2014 |
| NCT00400205 | Terminated | Phase 2 | Study of Induction Docetaxel, Cisplatin and 5-Fluorouracil | August 2006 | September 2009 |
| NCT02819752 | Terminated | Phase 1 | PEmbrolizumab Combined With Chemoradiotherapy in Squamous Cell Carcinoma of the Head and Neck | July 12, 2017 | November 28, 2019 |
| NCT02376699 | Terminated | Phase 1 | Safety Study of SEA-CD40 in Cancer Patients | February 28, 2015 | April 14, 2023 |
| NCT05061537 | Terminated | Phase 1 | Study of PF-07263689 in Participants With Selected Advanced Solid Tumors | October 20, 2021 | October 14, 2022 |
| NCT01794845 | Terminated | Phase 2 | Cetuximab + Taxotere With Low Dose Fractionated Radiation for Head and Neck Carcinoma | June 3, 2013 | June 7, 2016 |
| NCT01456143 | Terminated | N/A | Optical Imaging of Head and Neck Cancer | December 2011 | July 2014 |
| NCT02890368 | Terminated | Phase 1 | Trial of Intratumoral Injections of TTI-621 in Subjects With Relapsed and Refractory Solid Tumors and Mycosis Fungoides | September 2016 | March 31, 2020 |
| NCT03115476 | Terminated | Phase 3 | A Trial to Compare the Incidence of Squamous Cell Carcinoma (SCC) and Other Skin Neoplasia on Skin Areas Treated With Ingenol Disoxate Gel or Vehicle Gel for Actinic Keratosis on Face and Chest or Scalp | June 16, 2017 | March 12, 2018 |
| NCT03896958 | Unknown status | The PIONEER Initiative: Precision Insights On N-of-1 Ex Vivo Effectiveness Research Based on Individual Tumor Ownership (Precision Oncology) | March 21, 2019 | March 12, 2024 | |
| NCT02352428 | Unknown status | N/A | Skin Cancer Screening Education Study | February 2015 | September 2019 |
| NCT05340543 | Unknown status | Ex-vivo Examination of Excisions of Skin Tumors by Confocal Optical Coherence Tomography (LC-OCT) With Integrated Dermoscopy and Comparison With Histology (DERMOCTAV) | December 16, 2021 | June 16, 2022 | |
| NCT04435938 | Unknown status | Phase 2 | A Study of SBRT for Squamous Cell Carcinoma of the Head and Neck | September 10, 2020 | December 2022 |
| NCT05402046 | Unknown status | N/A | Clinical vAlidation of a MobilE appLication ("ProRodinki") in the Assessment of the maLignant skIn neoplAsms | April 23, 2022 | April 2024 |
| NCT04533321 | Unknown status | Phase 2 | A Biomarker-implemented Clinical Study Evaluating Mutations in MET and TP53 in a Population of Treatment-refractory Squamous Cell Carcinoma | September 2020 | September 2023 |
| NCT04628806 | Unknown status | Heat Shock Protein (HSP) 70 to Quantify and Characterize Circulating Tumor Cells | February 17, 2021 | May 2022 | |
| NCT00751543 | Unknown status | N/A | The Character of Perfusion Parameters Derived From MDCT Between Adenocarcinoma and Squamous Cell Carcinoma of Lung in the Treatment Course of Radiation Therapy | January 2008 | |
| NCT03025724 | Unknown status | N/A | Photodynamic Therapy for Treatment of Cutaneous Squamous Cell Carcinoma in Situ | January 2017 | January 2020 |
| NCT04922450 | Unknown status | Phase 2 | Clinical Study of Camrelizumab in Combination With Neoadjuvant Chemotherapy for Operable Locally Advanced Head and Neck Squamous Cell Carcinoma | January 20, 2021 | January 20, 2023 |
| NCT00662662 | Unknown status | Sexual Behavior in Head and Neck Cancer Patients | April 2008 | May 31, 2022 | |
| NCT03092830 | Unknown status | Molecular Characterization of Cutaneous Tumors | March 29, 2017 | August 7, 2020 | |
| NCT01760811 | Unknown status | Phase 1/Phase 2 | CETUXIMAB Given for 3 Weeks as Neoadjuvant Treatment in Locally Advanced Tongue Cancer ; A NEW PARADIGM OF TREATMENT | January 2013 | December 2017 |
| NCT02943044 | Unknown status | Quantitative Optical Sensor Findings in Head & Neck Squamous Cell Carcinoma | December 2016 | December 2017 | |
| NCT03486509 | Unknown status | Phase 2 | Afatinib Plus Chemotherapy Against Esophageal or Lung Squamous Cell Carcinoma | April 1, 2018 | July 1, 2020 |
| NCT01265472 | Unknown status | Comparison of Translocator Protein Expression and Binding Activity in Normal Tissue Versus Non Melanotic Malignancy | January 2011 | July 2011 | |
| NCT03292822 | Unknown status | Early Phase 1 | Effects of (Licochalcone A) and Paclitaxel on Human Oral Squamous Cell Carcinoma Cell Line | November 1, 2017 | April 1, 2019 |
| NCT03579004 | Unknown status | Phase 2 | Neoadjuvant Chemotherapy Followed by Preoperative Chemoradiation in Resectable Squamous-cell Esophageal Cancer | July 10, 2017 | July 10, 2020 |
| NCT03636685 | Unknown status | Phase 1/Phase 2 | Study of Anlotinib Plus Chemotherapy as the First-line Treatment in Patients With Advanced NSCLC | August 15, 2018 | August 14, 2020 |
| NCT02985255 | Unknown status | Phase 2 | Role of Neo-adjuvant Chemotherapy in Tongue Preservation in Locally Advanced Squamous Cell Carcinoma of Oral Tongue | April 2016 | June 2017 |
| NCT01232374 | Unknown status | Phase 2 | Nimotuzumab in Combination With Chemoradiation for Local Advanced Esophageal Squamous Cell Carcinoma | September 2010 | January 2016 |
| NCT03742726 | Unknown status | N/A | Study Assessing the Safety and Performance of Smart Matrix® | October 12, 2018 | January 2022 |
| NCT00426062 | Unknown status | Free Radical Level in SCC of Tongue Patients Tumor, Serum and Saliva | |||
| NCT03221400 | Unknown status | Phase 1/Phase 2 | PEN-866 in Patients With Advanced Solid Malignancies | August 29, 2017 | June 2023 |
| NCT03791905 | Unknown status | Phase 2 | PET Imaging-guided Chemoradiotherapy in Esophageal Squamous Cell Carcinoma | January 15, 2019 | December 2023 |
| NCT03837613 | Unknown status | Prognostic Value of Tumor Thickness of Buccal Mucosa Squamous Cell Carcinoma on the Incidence of Nodal Metastasis. | February 2019 | December 2019 | |
| NCT03985670 | Unknown status | Phase 2 | Teripalimab Plus Chemotherapy in Local Advanced Esophageal Cancer | July 10, 2019 | April 30, 2023 |
| NCT00605709 | Withdrawn | Phase 2 | Dose-Ranging Safety and Efficacy Study of Topical Creams Containing API 31510 for the Treatment of in Situ Cutaneous Squamous Cell Carcinoma | March 2008 | |
| NCT02298595 | Withdrawn | Phase 1/Phase 2 | Cetuximab, Cisplatin and BYL719 for HPV-Associated Oropharyngeal Squamous Cell Carcinoma | August 2016 | August 2024 |
| NCT03652233 | Withdrawn | Phase 1 | Afatinib and Nivolumab as Treatment for Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck | November 2, 2018 | November 2022 |
| NCT01484769 | Withdrawn | Method Development and Assessment of the Effects of Tobacco Products on Oral Cavity Cells | July 2005 | June 2012 | |
| NCT05729139 | Withdrawn | Phase 1 | Cemiplimab/Peg-Interferon-α in Advanced CSCC | July 2023 | July 2028 |
| NCT00038038 | Withdrawn | N/A | Assessment of Head and Neck Tumor Hypoxia Using 18F-Fluoromisonidazole | January 1994 | June 2003 |
| NCT04099446 | Withdrawn | A Non-Interventional Pilot Study to Explore the Skin Microbes in Skin Cancer | October 2019 | December 2020 | |
| NCT05535023 | Withdrawn | Phase 2 | Phase 2 Study of Neoadjuvant SAR444245 Plus Cemiplimab in HPV Related Oropharynx Squamous Cell Carcinoma | August 24, 2022 | July 25, 2023 |
| NCT00937300 | Withdrawn | Phase 1 | T-cell Based Immunotherapy for Head and Neck Cancer | June 2009 | June 2011 |
| NCT01148082 | Withdrawn | School Response to Families Who Have Children With Cancer | September 2010 | July 2011 |
- Disase is a (Disease Ontology)
- DOID:305
- Cross Reference ID (Disease Ontology)
- EFO:0000707
- Cross Reference ID (Disease Ontology)
- GARD:1091
- Cross Reference ID (Disease Ontology)
- ICDO:8070/3
- Cross Reference ID (Disease Ontology)
- MESH:D002294
- Cross Reference ID (Disease Ontology)
- MESH:D018307
- Cross Reference ID (Disease Ontology)
- NCI:C2929
- Cross Reference ID (Disease Ontology)
- SNOMEDCT_US_2023_03_01:1255006006
- Cross Reference ID (Disease Ontology)
- SNOMEDCT_US_2023_03_01:154605007
- Cross Reference ID (Disease Ontology)
- UMLS_CUI:C0007137
- Cross Reference ID (Disease Ontology)
- UMLS_CUI:C0751688
- Exact Synonym (Disease Ontology)
- epidermoid carcinoma
- Exact Synonym (Disease Ontology)
- malignant squamous cell tumor
- Exact Synonym (Disease Ontology)
- squamous carcinoma
- Exact Synonym (Disease Ontology)
- squamous cell cancer
- Exact Synonym (Disease Ontology)
- squamous cell Epithelioma
- HPO Human Phenotype ID (Human Phenotype Ontology)
- HP:0002860