Annotation Detail
Information
- Associated Genes
- IL6
- Associated Variants
-
IL6 MUTATION
IL6 MUTATION - Associated Disease
- Basal-Like Breast Carcinoma
- Source Database
- DisGeNET
- Description
- IL-6 mRNA is detectable only in basal-like breast carcinoma tissues; our results reveal that IL-6 triggers a Notch-3-dependent upregulation of the Notch ligand Jagged-1, whose interaction with Notch-3 promotes the growth of MS and Michigan Cancer Foundation-7 (MCF-7)-derived spheroids.
- Pubmed
- 25881039
- Section of the abstract supporting the evidence
- RESULTS
- Number of the section of the abstract supporting the evidence
- 3
- Number of the sentence supporting the evidence
- 10
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.000542883744160607
Drugs