Acute-On-Chronic Liver Failure
Information
- Disease name
- Acute-On-Chronic Liver Failure
- Disease ID
- Description
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
| Genes | Mutation | Description | Source | Links |
|---|
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT05434286 | Active, not recruiting | Point-of-Care Echocardiography to Assess Impact of Dynamic Cardiac Function, Renal and Cardiac Biomarkers in Cirrhosis With Hepatorenal Syndrome-Acute Kidney Injury | December 15, 2021 | June 15, 2023 | |
| NCT02321371 | Completed | N/A | Effect of Goal Directed Ammonia Lowering Therapy in Acute on Chronic Liver Failure Patients With Hepatic Encephalopathy. | October 19, 2014 | January 31, 2016 |
| NCT04983108 | Completed | Utility of Liver and Splenic Stiffness in Predicting Esophageal Varices in Patients With Acute on Chronic Liver Failure | September 18, 2021 | September 30, 2022 | |
| NCT02669680 | Completed | N/A | Granulocyte Colony Stimulating Factor (G-CSF) to Treat Acute-on-chronic Liver Failure | February 2016 | March 2020 |
| NCT03456518 | Completed | Pattern of Acute on Chronic Liver Failure in Patient With HCV Related Chronic Liver Disease | November 1, 2018 | November 30, 2019 | |
| NCT02946554 | Completed | Phase 2 | Phase II Safety Study of 2 Dose Regimens of HepaStem in Patients With ACLF | December 2016 | July 2020 |
| NCT03184636 | Completed | Acute-On-Chronic Liver Failure in Zagazig University Hospitals | July 1, 2017 | August 11, 2018 | |
| NCT03977857 | Completed | Prediction Model Based on Computed Tomography Liver Volume for the Short-term Mortality in Hepatitis B Related Acute-on-Chronic | March 1, 2019 | December 31, 2019 | |
| NCT04416282 | Completed | N/A | Efficacy of Early Terlipressin Plus Albumin Therapy in Comparison to Standard Treatment for HRS-AKI in Acute-on-chronic Liver Failure. | June 22, 2020 | June 10, 2022 |
| NCT04383106 | Completed | Bowel Colonization With Multi-drug Resistant Bacterial Species in Hospitalized Patients With acute-on Chronic Liver Failure (ACLF), and Its Relationship With Extra-intestinal Infectious Events and Short-term Outcomes. | June 1, 2020 | December 31, 2021 | |
| NCT04332484 | Completed | Global Coagulation Assessment in Cirrhosis and ACLF | January 1, 2018 | August 31, 2019 | |
| NCT04238416 | Completed | Phase 1 | Intravenous Branched Chain Amino Acids for Hepatic Encephalopathy in ACLF | November 1, 2019 | December 30, 2021 |
| NCT02965560 | Completed | Exploring Biomarkers Predicting the Outcome of Acute-on-chronic Liver Failure | October 10, 2016 | June 1, 2018 | |
| NCT06062706 | Enrolling by invitation | Robotic vs. Laparoscopic vs. Open Living Donor Hepatectomy | August 6, 2023 | October 30, 2023 | |
| NCT06377774 | Not yet recruiting | To Optimize Therapeutic Procedures of DPMAS in ACLF Patients: a Prospective, Sigle Arm and Multicenter Study | May 1, 2024 | February 1, 2026 | |
| NCT06142968 | Not yet recruiting | Acute on Chronic Liver Failure in Cirrhotic Patients at Assiut University Hospitals | December 2023 | October 2026 | |
| NCT06298656 | Not yet recruiting | Acute hemodynamiC Response To Carvedilol Predicts Survival in ACLF Patients | March 10, 2024 | February 28, 2026 | |
| NCT06069037 | Not yet recruiting | N/A | SALT for Treatment of Patients With Early ACLF | October 15, 2023 | December 30, 2025 |
| NCT05909319 | Not yet recruiting | Identification and Verification of Neutrophil Extracellular Trap Net Related Markers in Acute-on-chronic Liver Failure | June 25, 2023 | June 25, 2025 | |
| NCT04822922 | Not yet recruiting | Phase 2 | Safety of UC-MSC Transfusion for ACLF Patients | September 30, 2021 | July 21, 2024 |
| NCT05727722 | Not yet recruiting | Phase 1 | Micro-encapsulated Hepatocyte Intraperitoneal Transplantation in Liver Failure Adults | March 1, 2023 | June 30, 2024 |
| NCT05719051 | Not yet recruiting | Albumin Infusion in Inpatients With Decompensated Cirrhosis | February 1, 2023 | December 31, 2024 | |
| NCT06387160 | Not yet recruiting | To Determine the Predictors of Reversibility for Acute-on-Chronic Liver Failure at 6-months. | April 20, 2024 | February 27, 2026 | |
| NCT06079021 | Not yet recruiting | N/A | COOLEY- Study: aCute On chrOnic Liver failurE Using the cYtosorb Device | June 1, 2024 | June 30, 2027 |
| NCT05566548 | Recruiting | Role of Bilirubin Molecular Species in Hepatic Encephalopathy and Acute-on-chronic Liver Failure | August 1, 2022 | August 1, 2023 | |
| NCT04578301 | Recruiting | Predicting Acute-on-Chronic Liver Failure After Surgical Intervention in Chronic Liver Disease | September 22, 2020 | December 31, 2026 | |
| NCT05421351 | Recruiting | Immune Profile, Neuronal Dysfunction, Metabolomics and Ammonia in Therapeutic Response of HE in ACLF | October 2, 2022 | May 2025 | |
| NCT04613921 | Recruiting | Liver Transplantation in Patients With CirrHosis and Severe Acute-on-Chronic Liver Failure: iNdications and outComEs | July 8, 2021 | December 31, 2026 | |
| NCT05393453 | Recruiting | Prognosis of Patients With Acute-on-chronic Liver Failure | June 1, 2022 | June 1, 2025 | |
| NCT03702920 | Recruiting | Phase 3 | Short-term Survival of Subjects With Acute-on-chronic Liver Failure After Plasma Exchange With Human Serum Albumin 5% | February 21, 2019 | October 2026 |
| NCT05985863 | Recruiting | Phase 1/Phase 2 | Human Umbilical Cord Mesenchymal Stem Cell Transplantation for The Treatment of Acute-on-Chronic Liver Failure | September 30, 2023 | December 30, 2028 |
| NCT05030571 | Recruiting | N/A | The Effects of Double Plasma Molecular Adsorption System in Acute on Chronic Liver Failure Patients | January 1, 2021 | December 1, 2025 |
| NCT06128421 | Recruiting | N/A | Individual Nutrition Support in HBV-ACLF Patients at Nutrition Risk | November 23, 2023 | October 31, 2024 |
| NCT05900050 | Recruiting | Phase 2 | Efficacy, Safety and Tolerability of VS-01 in Adult Patients With Acute-on-Chronic Liver Failure and Ascites (UNVEIL-IT)™ | July 2, 2023 | June 2025 |
| NCT05700708 | Recruiting | Point-of-Care Echocardiography to Assess Impact of Dynamic Cardiac Function, Renal and Cardiac Biomarkers in Cirrhosis With Refractory Ascites | November 15, 2022 | July 15, 2024 | |
| NCT05700695 | Recruiting | Phase 1 | Intravenous BCAA for HE in ACLF (BCAA-HE-ACLF) | January 17, 2023 | April 25, 2025 |
| NCT06437067 | Recruiting | Study on Prognosis of Acute-on-chronic Liver Failure Complicated by Bacterial or Fungal Infection | March 1, 2023 | June 30, 2025 | |
| NCT05689645 | Recruiting | Phase 2 | F573 for Injection for the Treatment of Liver Injury/Failure | March 24, 2023 | March 31, 2026 |
| NCT04525625 | Recruiting | Risk Factors for Acute Kidney Injury in Critically Ill Patients With Acute-on-Chronic Liver Failure | February 1, 2021 | December 31, 2024 | |
| NCT04975490 | Recruiting | Characterization and Pathogenesis of ACLF | December 1, 2020 | December 31, 2025 | |
| NCT05382013 | Recruiting | Phase 4 | Efficacy and Safety of Avatrombopag for Treating TCP in HBV-ACLF Patients Receiving ALSS Treatment | April 27, 2022 | April 30, 2024 |
| NCT04157465 | Recruiting | N/A | Anti-fungal Strategies in Acute-on-Chronic Liver Failure Patients | November 7, 2019 | June 30, 2024 |
| NCT03737448 | Suspended | Phase 1 | TRimetazidine for acUte on Chronic Liver Failure STudy | November 28, 2018 | June 30, 2021 |
| NCT03860155 | Terminated | Phase 1/Phase 2 | Allogeneic ABCB5-positive Stem Cells for Treatment of Acute-on-Chronic Liver Failure | March 22, 2019 | March 26, 2021 |
| NCT05019352 | Unknown status | N/A | Cytokine Adsorption in Acute-on-chronic Liver Failure | October 25, 2021 | January 30, 2023 |
| NCT03668171 | Unknown status | N/A | Mesenchymal Stem Cell Transplantation for Acute-on-chronic Liver Failure | December 10, 2017 | December 31, 2020 |
| NCT03713489 | Unknown status | N/A | Platelet Transfusion in HBV-related acute-on Chronic Liver Failure | October 1, 2018 | September 30, 2019 |
| NCT03882346 | Unknown status | Phase 2 | Study to Evaluate Safety and Efficacy of LifeLiver in Acute or Acute-on-Chronic Liver Failure Patients | March 29, 2019 | June 2022 |
| NCT03920618 | Unknown status | N/A | Three Types of Nucleotide/Nucleoside Analogues Treatment in HBV Related ACLF | February 1, 2019 | December 31, 2023 |
| NCT03987893 | Unknown status | Phase 4 | PEG3350 in ACLF With Hepatic Encephalopathy | May 20, 2018 | August 20, 2020 |
| NCT04013113 | Unknown status | N/A | Efficacy and Safety of Hemoperfusion or Plasma Exchange Compared to Standard Medical Therapy in Patients With Acute on Chronic Liver Failure | July 9, 2019 | July 31, 2020 |
| NCT04051437 | Unknown status | Phase 3 | Plasma Exchange in Acute on Chronic Liver Failure | August 15, 2019 | March 31, 2020 |
| NCT04116242 | Unknown status | MERTK Signalling in Monocytes/Macrophages in Patients With Liver Disease | August 27, 2015 | December 2022 | |
| NCT04186572 | Unknown status | Usefulness of the Variation of the CLIF-C ACLF Score in Patients With Acute on Chronic Liver Failure | December 2019 | December 2021 | |
| NCT04195282 | Unknown status | N/A | RL-1 Novel Human-derived Bio-artificial Liver Treatment in Patients of HBV Related ACLF | December 2019 | December 2021 |
| NCT04243655 | Unknown status | Phase 4 | Use of HA 330-II for Hemofiltration in Patients With ALF as a Bridge to Liver Transplantation . | December 30, 2019 | December 31, 2020 |
| NCT04310787 | Unknown status | Long-term Prognosis of Patients With Hepatitis B Related Acute-on-chronic Liver Failure | May 15, 2020 | December 15, 2022 | |
| NCT04317222 | Unknown status | N/A | Early Postoperative CRRT After Liver Transplantation in ACLF Patients With Overt HE | June 1, 2020 | August 31, 2022 |
| NCT04431375 | Unknown status | N/A | Efficacy of Addition of Fecal Microbiota Transplant (FMT) and Plasma Exchange to Tenofovir in Comparison to Monotherapy With Tenofovir in ACLF-HBV | June 22, 2020 | June 10, 2022 |
| NCT04474262 | Unknown status | N/A | Efficacy of Albumin Plus Midodrine v/s Albumin Alone in Reducing Incidence of Paracentesis Induced Circulatory Dysfunctions in ACLF Patients. | July 15, 2020 | March 31, 2021 |
| NCT04564651 | Unknown status | N/A | Platelet Transfusion in Acute-on Chronic Liver Failure | May 1, 2019 | May 1, 2024 |
| NCT04597164 | Unknown status | Combination of DPMAS and Low Volume PE for Patients With HBV Related ACLF | December 22, 2020 | September 30, 2023 | |
| NCT04620148 | Unknown status | Phase 2 | TAK-242 in Patients With Acute Alcoholic Hepatitis | December 2021 | December 2022 |
| NCT04621812 | Unknown status | Role of Fecal Microbiota in Predicting Graft Rejection and Sepsis Among Recipients of Living Donor Liver Transplant in First Year. | November 8, 2020 | October 10, 2022 | |
| NCT04960163 | Unknown status | Incidence and Predictors of Bleeding Diathesis Development Due to DIC in Cirrhosis and ACLF Patients Undergoing CRRT | July 15, 2021 | October 31, 2021 | |
| NCT05036031 | Unknown status | Transplantation for EASL-CLIF and APASL ACLF Patients: a Retrospective Cohort Study | September 1, 2021 | October 31, 2021 | |
| NCT05441878 | Unknown status | Phase 4 | 20% Albumin vs. Balanced Salt Solution as Resuscitation Fluid in Cirrhosis With Sepsis Induced Hypotension | August 15, 2020 | December 2023 |
| NCT05940610 | Withdrawn | Phase 1/Phase 2 | The Safety and Efficacy of MSC-EVs in Acute/Acute-on-Chronic Liver Failure | September 1, 2023 | October 1, 2025 |
| NCT03629015 | Withdrawn | Phase 1 | Safety Study of Stemchymal® in Acute Liver Failure | October 1, 2018 | May 18, 2020 |
| NCT03162419 | Withdrawn | N/A | To Assess the Efficacy of High-Volume Plasma Exchange and GCSF Versus GCSF Alone in Patients of Acute on Chronic Liver Failure (ACLF). | May 1, 2017 | April 25, 2019 |
- MeSH unique ID (MeSH (Medical Subject Headings))
- D065290