gliosarcoma (Cancer)

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Information
Disease name
gliosarcoma
Disease ID
DOID:3071
Description
"A gliomablastoma that is characterized by a biphasic tissue pattern with alternating areas displaying glial and mesenchymal differentiation." [url:https\://en.wikipedia.org/wiki/Gliosarcoma, url:https\://www.cancer.gov/rare-brain-spine-tumor/tumors/gliosarcoma]
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
Genes Mutation Description Source Links
NCT ID Status Phase Summary Start date Completion date
NCT04216329 Active, not recruiting Phase 1 Selinexor (KPT-330) in Combination With Temozolomide and Radiation Therapy in Patients With Newly Diagnosed Glioblastoma July 7, 2020 July 30, 2026
NCT02152982 Active, not recruiting Phase 2/Phase 3 Temozolomide With or Without Veliparib in Treating Patients With Newly Diagnosed Glioblastoma Multiforme December 15, 2014 December 15, 2024
NCT03174197 Active, not recruiting Phase 1/Phase 2 Atezolizumab in Combination With Temozolomide and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma June 30, 2017 June 30, 2025
NCT04396860 Active, not recruiting Phase 2/Phase 3 Testing the Use of the Immunotherapy Drugs Ipilimumab and Nivolumab Plus Radiation Therapy Compared to the Usual Treatment (Temozolomide and Radiation Therapy) for Newly Diagnosed MGMT Unmethylated Glioblastoma September 1, 2020 March 11, 2025
NCT03137888 Active, not recruiting Phase 2 Spectroscopic MRI-Guided Radiation Therapy Planning in Glioblastoma September 20, 2017 January 4, 2025
NCT02455557 Active, not recruiting Phase 2 SurVaxM Vaccine Therapy and Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma May 4, 2015 December 30, 2024
NCT03452930 Active, not recruiting Phase 1 Tinostamustine With or Without Radiation Therapy in Treating Patients With Newly Diagnosed MGMT-Unmethylated Glioblastoma August 13, 2018 December 30, 2024
NCT02101905 Active, not recruiting Phase 1 Lapatinib Ditosylate Before Surgery in Treating Patients With Recurrent High-Grade Glioma March 13, 2014 October 19, 2024
NCT01430351 Active, not recruiting Phase 1 Temozolomide, Memantine Hydrochloride, Mefloquine, and Metformin Hydrochloride in Treating Patients With Glioblastoma Multiforme After Radiation Therapy September 14, 2011 September 30, 2025
NCT04397679 Active, not recruiting Phase 1 Partial Brain RT, Temozolomide, Chloroquine, and TTF Therapy for the Treatment of Newly Diagnosed Glioblastoma August 12, 2021 April 27, 2026
NCT00597402 Completed Phase 2 Avastin in Combination With Radiation (XRT) & Temozolomide, Followed by Avastin, Temozolomide and Irinotecan for Glioblastoma (GBM) and Gliosarcomas July 2007 May 2013
NCT00609999 Completed Phase 1 Ph I Dasatinib + Erlotinib in Recurrent MG January 2008 July 2010
NCT00610571 Completed Phase 1 Ph I Oral Topotecan and Temozolomide for Patients With Malignant Gliomas April 2004 April 2012
NCT00611325 Completed Phase 2 Phase II Avastin + Bortezomib for Patients With Recurrent Malignant Glioma May 2008 October 2013
NCT00612339 Completed Phase 2 Avastin in Combination With Temozolomide for Unresectable or Multifocal GBMs and Gliosarcomas August 2007 May 2012
NCT00612430 Completed Phase 2 Ph II Bevacizumab + Etoposide for Pts w Recurrent MG March 2007 September 2011
NCT00612638 Completed Phase 1 Ph. I Temozolomide + O6-BG + Irinotecan in Treatment of Pts w Recurrent / Progressive Cerebral Anaplastic Gliomas January 2005 July 2008
NCT00612651 Completed Phase 1 PH I Addition of Farnesyl Transferase Inhibitor to Temozolomide for Pts w Gr 3 & 4 Malignant Gliomas October 2005 June 2011
NCT00612989 Completed Phase 1 Ph I 5-day Temozolomide + O6-BG in Treatment of Pts w Recurrent / Progressive GBM February 2005 July 2008
NCT00613028 Completed Phase 2 Ph II Bev + Either Temozolomide/Etoposide for GBM Pts Who Have Failed Bev + Irinotecan April 2008 January 2011
NCT00613054 Completed Phase 1 Ph I Zactima + Imatinib Mesylate & Hydroxyurea for Pts w Recurrent Malignant Glioma November 2007 April 2009
NCT00613132 Completed Phase 1 Ph I Gleevec in Combo w RAD001 + Hydroxyurea for Pts w Recurrent MG May 2005 January 2013
NCT00613223 Completed Phase 1 Ph I Dose Escalation Trial of Vandetanib in Combo w Etoposide for Malignant Gliomas February 2008 May 2011
NCT00615927 Completed Phase 2 Phase II Imatinib + Hydroxyurea in Treatment of Patients With Recurrent/Progressive Grade II Low-Grade Glioma (LGG) February 2006 June 2012
NCT00657267 Completed Phase 2 Dose-Intense Temozolomide in Recurrent Glioblastoma May 2008 October 2013
NCT00031083 Completed Phase 1 Dose Escalation Study to Determine the Safety of IFN-Beta Gene Transfer in the Treatment of Grade III & Grade IV Gliomas April 2, 2002 October 10, 2003
NCT00671970 Completed Phase 2 Phase (Ph) II Bevacizumab + Erlotinib for Patients (Pts) With Recurrent Malignant Glioma (MG) February 2007 April 2010
NCT00672243 Completed Phase 2 Ph II Erlotinib + Sirolimus for Pts w Recurrent Malignant Glioma Multiforme April 2007 December 2009
NCT00734682 Completed Phase 1 A Phase I Trial of Nanoliposomal CPT-11 (NL CPT-11) in Patients With Recurrent High-Grade Gliomas August 2008 December 2014
NCT00879437 Completed Phase 2 Valproic Acid, Radiation, and Bevacizumab in Children With High Grade Gliomas or Diffuse Intrinsic Pontine Glioma September 1, 2009 October 2, 2017
NCT00884416 Completed Phase 1 Sorafenib in Newly Diagnosed High Grade Glioma March 2009 March 2012
NCT00884741 Completed Phase 3 Temozolomide and Radiation Therapy With or Without Bevacizumab in Treating Patients With Newly Diagnosed Glioblastoma April 15, 2009 March 17, 2013
NCT00960492 Completed Phase 1 Safety Study of XL184 (Cabozantinib) in Combination With Temozolomide and Radiation Therapy in the Initial Treatment of Adults With Glioblastoma September 2009 October 2013
NCT00979017 Completed Phase 2 Avastin/Temozolomide/Irinotecan for Unresectable/Multifocal Glioblastoma Multiforme November 2009 January 2013
NCT00995007 Completed Phase 2 A Randomized Phase II Trial of Vandetanib (ZD6474) in Combination With Carboplatin Versus Carboplatin Alone Followed by Vandetanib Alone in Adults With Recurrent High-Grade Gliomas September 2009 December 2015
NCT01004874 Completed Phase 2 Avastin/Radiation (XRT)/Temozolomide (Temodar) Followed by Avastin/Temodar/Topotecan for Glioblastoma December 30, 2009 November 2, 2021
NCT01082926 Completed Phase 1 Phase I Study of Cellular Immunotherapy for Recurrent/Refractory Malignant Glioma Using Intratumoral Infusions of GRm13Z40-2, An Allogeneic CD8+ Cytolitic T-Cell Line Genetically Modified to Express the IL 13-Zetakine and HyTK and to be Resistant to Glucocorticoids, in Combination With Interleukin-2 May 2010 September 2013
NCT01113398 Completed Phase 2 AMG 102 and Avastin for Recurrent Malignant Glioma August 2010 September 2015
NCT00667394 Completed Phase 2 Tandutinib Plus Bevacizumab to Treat Recurrent Brain Tumors April 2008 July 2011
NCT00087451 Completed Phase 1 Safety Study of AP23573 in Patients With Progressive or Recurrent Glioma (8669-023)(COMPLETED) July 2004 November 2005
NCT00100802 Completed Phase 2 Radiation Therapy, Temozolomide, and Lomustine in Treating Young Patients With Newly Diagnosed Gliomas March 21, 2005 June 30, 2017
NCT00107003 Completed Phase 2 GW572016 to Treat Recurrent Malignant Brain Tumors March 30, 2005 November 30, 2012
NCT00165477 Completed Phase 2 Study of Lenalidomide and XRT in Patients With Newly Diagnosed Glioblastoma Multiforme September 2005 July 2009
NCT00187486 Completed Phase 2 Safety and Efficacy Study of Tarceva, Temodar, and Radiation Therapy in Patients With Newly Diagnosed Brain Tumors August 2004 March 2011
NCT00354913 Completed Phase 2 Imatinib Mesylate and Hydroxyurea in Treating Patients With Recurrent or Progressive Meningioma May 2005 October 2010
NCT00402116 Completed Phase 1/Phase 2 Phase 1/2 Study of Enzastaurin in Newly Diagnosed Glioblastoma Multiforme (GBM) and Gliosarcoma (GS) Patients September 2006 December 2009
NCT00441142 Completed Phase 1/Phase 2 Zactima With Temodar During Radiation Treatment for Newly Diagnosed Stage IV Brain Tumors May 25, 2007 October 10, 2017
NCT00525525 Completed Phase 2 Study of Bevacizumab Plus Temodar and Tarceva in Patients With Glioblastoma or Gliosarcoma September 2007 May 2013
NCT01149850 Completed Phase 2 Bevacizumab and Temozolomide in Treating Older Patients With Newly-Diagnosed Glioblastoma Multiforme or Gliosarcoma April 28, 2010 December 8, 2023
NCT01189266 Completed Phase 1/Phase 2 Vorinostat and Radiation Therapy Followed by Maintenance Therapy With Vorinostat in Treating Younger Patients With Newly Diagnosed Diffuse Intrinsic Pontine Glioma August 9, 2010 September 30, 2021
NCT01250470 Completed Phase 1 Vaccine Therapy and Sargramostim in Treating Patients With Malignant Glioma September 5, 2012 May 29, 2014
NCT01380782 Completed Phase 2 BIBF 1120 for Recurrent High-Grade Gliomas May 2012 July 2014
NCT01454596 Completed Phase 1/Phase 2 CAR T Cell Receptor Immunotherapy Targeting EGFRvIII for Patients With Malignant Gliomas Expressing EGFRvIII May 16, 2012 January 17, 2019
NCT01480479 Completed Phase 3 Phase III Study of Rindopepimut/GM-CSF in Patients With Newly Diagnosed Glioblastoma November 2011 November 2016
NCT01498328 Completed Phase 2 A Study of Rindopepimut/GM-CSF in Patients With Relapsed EGFRvIII-Positive Glioblastoma December 2011 May 17, 2016
NCT01514201 Completed Phase 1/Phase 2 Veliparib, Radiation Therapy, and Temozolomide in Treating Younger Patients With Newly Diagnosed Diffuse Pontine Gliomas February 1, 2012 March 28, 2018
NCT01609790 Completed Phase 2 Bevacizumab With or Without Trebananib in Treating Patients With Recurrent Brain Tumors June 4, 2012 May 20, 2022
NCT01740258 Completed Phase 2 Bevacizumab Beyond Progression (BBP) January 2013 November 14, 2019
NCT01856933 Completed Phase 2 BrUOG 263: Prostate Specific Membrane Antigen (PSMA) Glioblastoma Multiforme (GBM) May 2013 February 2015
NCT01922076 Completed Phase 1 Adavosertib and Local Radiation Therapy in Treating Children With Newly Diagnosed Diffuse Intrinsic Pontine Gliomas September 3, 2013 September 30, 2022
NCT01931098 Completed Phase 2 Oral Pazopanib Plus Oral Topotecan Metronomic Antiangiogenic Therapy for Recurrent Glioblastoma Multiforme (A) Without Prior Bevacizumab Exposure and (B) After Failing Prior Bevacizumab December 10, 2015 September 12, 2019
NCT01957956 Completed Early Phase 1 Vaccine Therapy and Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma November 11, 2013 November 16, 2016
NCT01975116 Completed Phase 1 p28 in Treating Younger Patients With Recurrent or Progressive Central Nervous System Tumors August 2013 April 2015
NCT02052648 Completed Phase 1/Phase 2 Study of IDO Inhibitor and Temozolomide for Adult Patients With Primary Malignant Brain Tumors March 2014 June 20, 2019
NCT02311920 Completed Phase 1 Ipilimumab and/or Nivolumab in Combination With Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma or Gliosarcoma April 16, 2015 December 22, 2022
NCT02386826 Completed Phase 1 INC280 Combined With Bevacizumab in Patients With Glioblastoma Multiforme September 22, 2015 August 23, 2023
NCT02502708 Completed Phase 1 Study of the IDO Pathway Inhibitor, Indoximod, and Temozolomide for Pediatric Patients With Progressive Primary Malignant Brain Tumors October 2015 February 28, 2020
NCT02573324 Completed Phase 3 A Study of ABT-414 in Participants With Newly Diagnosed Glioblastoma (GBM) With Epidermal Growth Factor Receptor (EGFR) Amplification January 4, 2015 April 4, 2022
NCT02658981 Completed Phase 1 Anti-LAG-3 Alone & in Combination w/ Nivolumab Treating Patients w/ Recurrent GBM (Anti-CD137 Arm Closed 10/16/18) August 24, 2016 October 3, 2023
NCT02661282 Completed Phase 1/Phase 2 Autologous CMV-Specific Cytotoxic T Cells and Temozolomide in Treating Patients With Glioblastoma June 1, 2016 February 23, 2022
NCT02709226 Completed Phase 1 Dose Escalation Trial of Re-irradiation in Good Prognosis Recurrent Glioblastoma June 15, 2016 July 19, 2023
NCT02798406 Completed Phase 2 Combination Adenovirus + Pembrolizumab to Trigger Immune Virus Effects October 6, 2016 June 30, 2021
NCT02942264 Completed Phase 1/Phase 2 Zotiraciclib (TG02) Plus Dose-Dense or Metronomic Temozolomide Followed by Randomized Phase II Trial of Zotiraciclib (TG02) Plus Temozolomide Versus Temozolomide Alone in Adults With Recurrent Anaplastic Astrocytoma and Glioblastoma December 14, 2016 August 26, 2020
NCT03020017 Completed Early Phase 1 NU-0129 in Treating Patients With Recurrent Glioblastoma or Gliosarcoma Undergoing Surgery May 25, 2017 August 19, 2020
NCT03020602 Completed Phase 1 BPM31510 in Treating Patients With Recurrent High-Grade Glioma Previously Treated With Bevacizumab January 4, 2017 June 26, 2021
NCT03043391 Completed Phase 1 Phase 1b Study PVSRIPO for Recurrent Malignant Glioma in Children November 7, 2017 March 23, 2022
NCT04091503 Completed Phase 1 Evaluate the Safety and Effectiveness of Intranasal Administration of Temozolomide in Patients With Glioblastoma December 20, 2019 October 28, 2022
NCT05756985 Not yet recruiting Improving Understanding of Glioblastoma Through Preservation of Biologically Active Brain Tissue June 2024 June 2028
NCT04528680 Recruiting Phase 1/Phase 2 Ultrasound-based Blood-brain Barrier Opening and Albumin-bound Paclitaxel and Carboplatin for Recurrent Glioblastoma October 29, 2020 September 2025
NCT05095376 Recruiting Phase 3 Testing the Addition of the Chemotherapy Drug Lomustine (Gleostine®) to the Usual Treatment (Temozolomide and Radiation Therapy) for Newly Diagnosed MGMT Methylated Glioblastoma November 29, 2021 August 8, 2031
NCT04555577 Recruiting Phase 1 Peposertib and Radiation Therapy, Followed by Temozolomide for the Treatment of Patients With Newly Diagnosed MGMT Unmethylated Glioblastoma or Gliosarcoma September 20, 2020 October 30, 2025
NCT05698524 Recruiting Phase 1 A Study of Temodar With Abexinostat (PCI-24781) for Patients With Recurrent Glioma June 26, 2023 June 2027
NCT05864534 Recruiting Phase 2 Phase 2a Immune Modulation With Ultrasound for Newly Diagnosed Glioblastoma January 31, 2024 August 2026
NCT03107780 Recruiting Phase 1 Testing the Ability of AMG 232 (KRT 232) to Get Into the Tumor in Patients With Brain Cancer July 9, 2018 December 31, 2024
NCT03115333 Recruiting N/A DSC-MRI in Measuring rCBV for Early Response to Bevacizumab in Patients With Recurrent Glioblastoma July 25, 2017 May 7, 2027
NCT04817254 Recruiting Phase 2 Association of Peripheral Blood Immunologic Response to Therapeutic Response to Adjuvant Treatment With Immune Checkpoint Inhibition (ICI) in Patients With Newly Diagnosed Glioblastoma or Gliosarcoma December 8, 2021 December 31, 2026
NCT03746080 Recruiting Phase 2 Whole Brain Radiation Therapy With Standard Temozolomide Chemo-Radiotherapy and Plerixafor in Treating Patients With Glioblastoma December 4, 2018 July 2027
NCT05084430 Recruiting Phase 1/Phase 2 Study of Pembrolizumab and M032 (NSC 733972) February 25, 2022 March 1, 2028
NCT05091866 Recruiting Early Phase 1 Natural Progesterone for the Treatment of Recurrent Glioblastoma April 11, 2022 August 25, 2026
NCT01837862 Recruiting Phase 1/Phase 2 A Phase I Study of Mebendazole for the Treatment of Pediatric Gliomas October 22, 2013 April 2025
NCT03197506 Suspended Phase 2 Pembrolizumab and Standard Therapy in Treating Patients With Glioblastoma September 15, 2017 August 31, 2024
NCT02168270 Terminated Phase 1 Temozolomide and Ascorbic Acid in Treating Patients With Recurrent High-Grade Glioma June 16, 2014 August 20, 2015
NCT00365222 Terminated Phase 2 Phase II Study of Temozolomide in Newly Diagnosed Glioblastoma July 2006 June 2007
NCT00735436 Terminated Phase 2 A Study of Gliadel Followed by Avastin + Irinotecan for Glioblastoma Multiforme (GBM) December 2008 October 2012
NCT00035373 Terminated Eligibility Screening of Patients With Central Nervous System Tumors for the National Cancer Institute s (NCI) Clinical Research Protocols April 19, 2002 April 29, 2015
NCT02664363 Terminated Phase 1 EGFRvIII CAR T Cells for Newly-Diagnosed WHO Grade IV Malignant Glioma February 1, 2017 September 12, 2019
NCT02743078 Terminated Phase 2 Optune® Plus Bevacizumab in Bevacizumab-Refractory Recurrent Glioblastoma May 9, 2017 October 15, 2019
NCT01186406 Terminated Phase 2 Gliadel, XRT, Temodar, Avastin Followed by Avastin, Temodar for Newly Diagnosed Glioblastoma Multiforme (GBM) April 2011 June 16, 2014
NCT01227434 Terminated Phase 2 A Study of PD 0332991 in Patients With Recurrent Rb Positive Glioblastoma September 2010 December 2013
NCT01095094 Terminated Phase 2 Ritonavir and Lopinavir in Treating Patients With Progressive or Recurrent High-Grade Glioma January 2009 November 2011
NCT01721577 Terminated Phase 1/Phase 2 Phase I/II Trial of AXL1717 in the Treatment of Recurrent Malignant Astrocytomas December 2012 December 2015
NCT01814813 Terminated Phase 2 Vaccine Therapy With Bevacizumab Versus Bevacizumab Alone in Treating Patients With Recurrent Glioblastoma Multiforme That Can Be Removed by Surgery May 2013 May 1, 2023
NCT01836549 Terminated Phase 2 Imetelstat Sodium in Treating Younger Patients With Recurrent or Refractory Brain Tumors March 2013 April 2016
NCT00669669 Terminated Phase 1/Phase 2 O6-Benzylguanine-Mediated Tumor Sensitization With Chemoprotected Autologous Stem Cell in Treating Patients With Malignant Gliomas February 25, 2009 January 20, 2021
NCT03641326 Terminated Phase 2 Sunitinib in Sarcomas of the Central Nervous System February 21, 2019 April 2, 2021
NCT03843814 Terminated N/A Pilot Study Using Amide Proton Transfer Magnetic Resonance Imaging Distinguishing Glioma August 2014 December 13, 2017
NCT03973918 Terminated Phase 2 Study of Binimetinib With Encorafenib in Adults With Recurrent BRAF V600-Mutated HGG July 29, 2019 October 1, 2023
NCT01086345 Terminated Early Phase 1 Radiosurgery Plus Bevacizumab in Glioblastoma February 2010 December 2014
NCT02133183 Terminated Phase 1 Sapanisertib Before and After Surgery in Treating Patients With Recurrent Glioblastoma July 2, 2014 October 31, 2023
NCT00734526 Terminated Phase 1 Phase I Portion of Phase I/II Sorafenib With Radiation and Temozolomide in Newly Diagnosed Glioblastoma or Gliosarcoma December 18, 2008 December 2012
NCT00114309 Unknown status Phase 2 131-I-TM-601 Study in Adults With Recurrent High-Grade Glioma November 2004 August 2009
NCT00936052 Unknown status Phase 2 Hyperbaric Hyperoxygenation With Radiotherapy and Temozolomide in Adults With Newly Diagnosed Glioblastoma December 2008 December 2010
NCT01124539 Unknown status Phase 2 Study of AR-67 in Adult Patients With Recurrence of Glioblastoma Multiforme (GBM) or Gliosarcoma December 2009 February 2015
NCT03401866 Unknown status N/A Multi-site Validation and Application of a Consensus DSC-MRI Protocol February 2018 July 2021
NCT01903330 Unknown status Phase 2 ERC1671/GM-CSF/Cyclophosphamide for the Treatment of Glioblastoma Multiforme March 2014 March 2023
NCT03275558 Withdrawn Phase 1 Clinical Trial of the Use of the Nasal Spray of Patients With Recurrence of Glioblastoma July 17, 2018 July 17, 2018
NCT03014804 Withdrawn Phase 2 Autologous Dendritic Cells Pulsed With Tumor Lysate Antigen Vaccine and Nivolumab in Treating Patients With Recurrent Glioblastoma December 1, 2019 December 1, 2022
NCT00734864 Withdrawn Phase 1 Ph. I Dasatinib/Protracted Temozolomide in Recurrent Malignant Glioma June 2009 June 2012
NCT02599090 Withdrawn Phase 2 Phase II Sorafenib With Radiation and Temozolomide in Newly Diagnosed Glioblastoma or Gliosarcoma December 2008 December 2012
Disase is a (Disease Ontology)
DOID:3068
Cross Reference ID (Disease Ontology)
GARD:5653
Cross Reference ID (Disease Ontology)
ICDO:9442/3
Cross Reference ID (Disease Ontology)
MESH:D018316
Cross Reference ID (Disease Ontology)
NCI:C3796
Cross Reference ID (Disease Ontology)
SNOMEDCT_US_2023_03_01:35262004
Cross Reference ID (Disease Ontology)
UMLS_CUI:C0206726
Exact Synonym (Disease Ontology)
Glioblastoma with sarcomatous component
MeSH unique ID (MeSH (Medical Subject Headings))
D018316