Hypoxic-Ischemic Encephalopathy
Information
- Disease name
- Hypoxic-Ischemic Encephalopathy
- Disease ID
- Description
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
| Genes | Mutation | Description | Source | Links |
|---|
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT04337697 | Active, not recruiting | Neonatal Seizure Registry - Developmental Functional EValuation | March 15, 2020 | September 29, 2024 | |
| NCT05048550 | Active, not recruiting | N/A | Babies in Glasses; a Feasibility Study. | September 9, 2021 | December 31, 2023 |
| NCT03179553 | Active, not recruiting | Heart Beat Variability in Neonatal Encephalopathy | August 15, 2017 | November 28, 2025 | |
| NCT03913221 | Active, not recruiting | Phase 1 | Caffeine for Hypoxic-Ischemic Encephalopathy | July 12, 2019 | December 2024 |
| NCT01059461 | Completed | Phase 2 | Study of Cerebrolysin for Treatment of Infants With History of Neonatal Hypoxic Ischemic Encephalopathy | March 2011 | September 2013 |
| NCT00614744 | Completed | N/A | Late Hypothermia for Hypoxic-Ischemic Encephalopathy | April 2008 | June 2016 |
| NCT01747863 | Completed | Prospective Research in Infants With Mild Encephalopathy | December 2012 | June 2017 | |
| NCT01793129 | Completed | N/A | Preemie Hypothermia for Neonatal Encephalopathy | May 2015 | December 9, 2022 |
| NCT01913340 | Completed | Phase 1/Phase 2 | Neonatal Erythropoietin And Therapeutic Hypothermia Outcomes in Newborn Brain Injury (NEATO) | September 2013 | September 2016 |
| NCT01936246 | Completed | N/A | Protein Supplementation in Infants With Brain Injury | August 2012 | February 2016 |
| NCT02256618 | Completed | Phase 1 | Autologous Cord Blood Cell Therapy for Neonatal Encephalopathy | August 2014 | July 2019 |
| NCT02264808 | Completed | Developmental Outcomes | November 2014 | December 3, 2018 | |
| NCT02529202 | Completed | Early Phase 1 | Dexmedetomidine Pharmacokinetics in Neonates During Therapeutic Hypothermia | March 2016 | January 2017 |
| NCT02544542 | Completed | N/A | Clinical Trial of a New Rectum Cooling System on Patients of Hypoxic-ischemic Brain Damage | January 2014 | October 2016 |
| NCT02700828 | Completed | Phase 2/Phase 3 | Hydrocortisone Treatment In Systemic Low Blood Pressure During Hypothermia in Asphyxiated Newborns | February 2016 | December 15, 2022 |
| NCT03024021 | Completed | Cerebral Oxymetry and Neurological Outcome in Therapeutic Hypothermia | September 2016 | December 2018 | |
| NCT03079167 | Completed | Phase 3 | PAEAN - Erythropoietin for Hypoxic Ischaemic Encephalopathy in Newborns | May 14, 2016 | April 30, 2024 |
| NCT03079284 | Completed | N/A | Holding, Stress, and Bonding During Therapeutic Hypothermia | March 20, 2017 | September 23, 2017 |
| NCT06344286 | Completed | N/A | The Effects of Minimal Enteral Nutrition on Mesenteric Blood Flow and Oxygenation in Neonates With HIE | September 1, 2020 | October 31, 2022 |
| NCT05687708 | Completed | N/A | Effect of Non-nutritive Sucking on Transition to Oral Feeding in Infants With Asphyxia | November 1, 2021 | July 25, 2023 |
| NCT00808704 | Completed | Phase 1/Phase 2 | Neurological Outcome After Erythropoietin Treatment for Neonatal Encephalopathy | August 2003 | July 2008 |
| NCT00817401 | Completed | Phase 1/Phase 2 | Systemic Hypothermia Improves Outcome of Hypoxic-Ischemic Encephalopathy | July 2002 | June 2008 |
| NCT03837717 | Completed | N/A | The Impact of Holding on Stress and Bonding in Mother-Infant Pairs During Therapeutic Hypothermia | December 4, 2018 | February 8, 2021 |
| NCT00890409 | Completed | Phase 3 | Safety and Efficacy of Hypothermia to Treat Neonatal Hypoxic-Ischemic Encephalopathy | May 2002 | August 2005 |
| NCT05379218 | Completed | N/A | RIC in HIE: A Safety and Feasibility Trial | January 17, 2022 | February 5, 2024 |
| NCT03485781 | Completed | Propofol-induced EEG Changes in Hypoxic Brain Injury | October 12, 2017 | July 10, 2019 | |
| NCT04506788 | Completed | EEG Slow Wave Activity in Hypoxic Brain Injury | June 15, 2015 | June 12, 2017 | |
| NCT00719407 | Completed | Phase 1 | Neonatal Erythropoietin in Asphyxiated Term Newborns | January 2010 | November 2012 |
| NCT03640494 | Completed | Bedside Optical Retinal Assessment of Hypoxic Ischemic Encephalopathy in Infants | August 28, 2018 | February 28, 2021 | |
| NCT05495607 | Completed | Continous Renal Replacement Therapy With the CARPEDIEM® in a French National Cohort of 25 Neonates and Small Infants | December 1, 2018 | January 1, 2022 | |
| NCT02260271 | Enrolling by invitation | Florida Neonatal Neurologic Network | September 2011 | December 2024 | |
| NCT05514665 | Not yet recruiting | Functional Imaging of Baby Brains | March 2024 | April 1, 2026 | |
| NCT06429007 | Not yet recruiting | Phase 2 | A Safety and Feasibility Trial Protocol of Metformin in Infants After Perinatal Brain Injury | October 1, 2024 | October 1, 2027 |
| NCT04913324 | Not yet recruiting | N/A | Early Virtual Intervention for Infants With CP Following HIE Diagnosis | June 1, 2021 | December 31, 2026 |
| NCT06448780 | Not yet recruiting | Phase 1 | Dose Optimization of Caffeine for HIE | November 2024 | November 2028 |
| NCT06460480 | Recruiting | Monitoring After Cardiac Arrest: Electroencephalogram and Cerebral Oximetry in Predicting Outcome | June 15, 2024 | October 30, 2024 | |
| NCT03549520 | Recruiting | Phase 3 | CEUS Evaluation of Hypoxic Ischemic Injury | December 1, 2020 | September 2024 |
| NCT03657394 | Recruiting | N/A | Comparative Outcomes Related to Delivery-room Cord Milking In Low-resourced Kountries | October 17, 2022 | June 16, 2024 |
| NCT03682042 | Recruiting | N/A | Comparative Outcomes Related to Delivery-room Cord Milking In Low-resourced Kountries Developmental Follow Up | October 17, 2022 | June 30, 2027 |
| NCT04602325 | Recruiting | Systemic Biomarkers of Brain Injury From Hyperammonemia | July 9, 2020 | May 2027 | |
| NCT04772222 | Recruiting | Phase 2 | Dexmedetomidine Use in Infants Undergoing Cooling Due to Neonatal Encephalopathy (DICE Trial) | June 20, 2022 | August 30, 2025 |
| NCT05130528 | Recruiting | N/A | Therapeutic Intervention Supporting Development From NICU to 6 Months for Infants Post Hypoxic-Ischemic Encephalopathy | February 18, 2022 | April 30, 2024 |
| NCT05361070 | Recruiting | Neonatal Seizure Registry, GEnetics of Post-Neonatal Epilepsy | August 9, 2022 | February 28, 2027 | |
| NCT05514340 | Recruiting | Phase 2 | Assess Safety and Efficacy of Sovateltide in Hypoxic-ischemic Encephalopathy | September 6, 2023 | December 2024 |
| NCT05520359 | Recruiting | N/A | Spinal Stimulation and Mobility Devices | August 4, 2022 | December 2024 |
| NCT05568264 | Recruiting | N/A | Effects of a Physical Therapy Intervention on Motor Delay in Infants Admitted to a Neonatal Intensive Care Unit | October 1, 2022 | December 31, 2026 |
| NCT05610085 | Recruiting | Phase 2 | A Dose Escalation Study of Levetiracetam in the Treatment of Neonatal Seizures | March 24, 2023 | December 31, 2027 |
| NCT05778188 | Recruiting | Phase 2 | A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of RLS-0071 in Newborns With Moderate or Severe Hypoxic-Ischemic Encephalopathy Undergoing Therapeutic Hypothermia | July 27, 2023 | April 2026 |
| NCT05787899 | Recruiting | Hypothermia's Effect on Hepatitis B Vaccination | May 18, 2023 | January 1, 2025 | |
| NCT05836610 | Recruiting | Phase 4 | Hydrocortisone Therapy Optimization During Hypothermia Treatment in Asphyxiated Neonates | September 21, 2021 | September 2027 |
| NCT05901688 | Recruiting | Umbilical Cord Abnormalities in the Prediction of Adverse Pregnancy Outcomes | October 3, 2023 | December 31, 2025 | |
| NCT05971446 | Recruiting | Healthy Little Eyes | February 24, 2020 | July 2024 | |
| NCT05986994 | Recruiting | Identification of a Pool of miRNA to Improve Early Management of Perinatal Asphyxia and Hypoxic Ischemic Encephalopathy | July 18, 2023 | July 18, 2024 | |
| NCT06090968 | Recruiting | N/A | Umbilical Cord Milking Versus Immediate Cord Clamping in Full Term Neonates (≥ 37 Weeks) Requiring Resuscitation | February 5, 2022 | February 4, 2024 |
| NCT06195345 | Recruiting | Individual Cerebral Hemodynamic Oxygenation Relationships (ICHOR 1) | November 1, 2018 | November 2025 | |
| NCT06427642 | Recruiting | N/A | Efficacy Evaluation of UCB-MNCs in the Treatment of Refractory Neonatal Diseases | April 1, 2022 | April 30, 2025 |
| NCT04445649 | Recruiting | Prognostic Factors to Regain Consciousness | June 15, 2020 | December 15, 2025 | |
| NCT01192776 | Terminated | N/A | Optimizing (Longer, Deeper) Cooling for Neonatal Hypoxic-Ischemic Encephalopathy(HIE) | September 2010 | March 2016 |
| NCT03246243 | Terminated | Quantitative Assessment of Sucking for Early Diagnosis of Brain Injury in Infants at High Risk | March 29, 2017 | May 18, 2021 | |
| NCT03534466 | Terminated | N/A | Evaluation of Long-Term Gait Development in Infants With Neonatal Encephalopathy Using Infant Treadmill | December 1, 2020 | June 30, 2021 |
| NCT03079492 | Unknown status | MRI of Neonate With HIE Before and During the Moderate Hypothermia | June 1, 2017 | May 31, 2020 | |
| NCT03786497 | Unknown status | Protecting Brains and Saving Futures - the PBSF Protocol | January 1, 2021 | December 31, 2023 | |
| NCT03163589 | Unknown status | Phase 3 | Erythropoietin in Management of Neonatal Hypoxic Ischemic Encephalopathy | December 1, 2017 | June 1, 2020 |
| NCT02854579 | Unknown status | N/A | Neural Progenitor Cell and Paracrine Factors to Treat Hypoxic Ischemic Encephalopathy | January 2013 | December 2017 |
| NCT03123081 | Unknown status | N/A | Role of Umbilical Cord Milking in the Management of Hypoxic-ischemic Encephalopathy in Neonates | January 1, 2018 | July 1, 2022 |
| NCT03181646 | Unknown status | Phase 3 | Role of Citicoline in Treatment of Newborns With Hypoxic Ischemic Encephalopathy | June 15, 2017 | December 15, 2017 |
| NCT03806816 | Unknown status | N/A | Use of Melatonin for Neuroprotection in Asphyxiated Newborns | December 13, 2018 | December 31, 2022 |
| NCT04766541 | Unknown status | THE ROLE OF CARDIAC MARKERS IN HYPOXIC ISCHEMIC ENCEPHALOPATHY IN LONG-TERM NEURODEVELOPMENTAL FOLLOW UP | December 30, 2020 | June 30, 2021 | |
| NCT02894866 | Unknown status | N/A | Hyperbaric Oxygen Therapy Improves Outcome of Hypoxic-Ischemic Encephalopathy | October 2016 | September 2021 |
| NCT03352310 | Unknown status | Phase 1 | Feasibility and Safety of Umbilical Cord Blood Transfusion in the Treatment of Neonatal Cerebral Ischemia and Anemia | April 16, 2018 | December 30, 2020 |
| NCT03681314 | Withdrawn | N/A | Umbilical Cord Milking in Neonates Who Are Depressed at Birth-Developmental Follow Up (MIDAB-FU) | October 17, 2022 | August 16, 2026 |
| NCT05295784 | Withdrawn | Phase 1 | PK and Safety of Caffeine in Neonates With Hypoxic Ischemic Encephalopathy Receiving Therapeutic Hypothermia | May 8, 2024 | May 8, 2024 |
| NCT03996317 | Withdrawn | N/A | Maternal Hyperoxygenation for Intrapartum Fetal Heart Rate Tracing Abnormalities | June 2021 | December 30, 2022 |
| NCT03527498 | Withdrawn | N/A | Evaluation of Long-term Neurodevelopment in Neonatal Encephalopathy by Infant Treadmill | December 1, 2020 | December 31, 2022 |