chr2:113587328:> Detail (hg19)

Information

Genome

Assembly Position
hg19 chr2:113,587,328-113,594,356
hg38 chr2:112,829,751-112,836,779 

HGVS

Type Transcript Protein
Summary

MGeND

Clinical significance
Variant entry
GWAS entry
Disease area statistics Show details

Frequency

[No Data.]

Prediction

[No Data.]

ClinVar

Clinical Significance
Review star [No Data.]
Show details
Links
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
[No Data.]
CIViC
[No Data.]
DisGeNET
Score Disease name Description Source Pubmed Links
0.012 squamous cell carcinoma NA BeFree,GAD,LHGDN Detail
<0.001 Carcinoma, Transitional Cell NA BeFree Detail
0.003 Cardiomyopathy, Dilated NA BeFree,GAD Detail
0.065 Malignant neoplasm of stomach In the Chinese subgroup, nominally significant associations were shown between (... BeFree 21649724 Detail
0.028 stomach carcinoma In the Chinese subgroup, nominally significant associations were shown between (... BeFree 21649724 Detail
0.027 Helicobacter pylori infection In the Chinese subgroup, nominally significant associations were shown between (... BeFree 21649724 Detail
0.011 Cardiovascular Diseases Genome-wide gene expression profiling by MACE (Massive Analysis of cDNA Ends) id... BeFree,GAD 24184689 Detail
0.015 celiac disease NA BeFree,GAD,LHGDN Detail
<0.001 intracranial aneurysm NA BeFree Detail
0.002 intracranial arteriosclerosis NA GAD Detail
0.002 Intracranial Arteriovenous Malformation NA GAD Detail
0.003 cerebral infarction NA BeFree,GAD Detail
0.132 brain ischemia NA CTD_human,GAD Detail
0.080 Transient ischemic attack NA RGD Detail
0.003 cerebral palsy NA BeFree,GAD Detail
0.002 Malignant tumor of cervix Interleukin 1β and interleukin 1 receptor antagonist gene polymorphisms and cerv... BeFree 24905619 Detail
0.005 Uterine Cervical Neoplasm NA BeFree,GAD Detail
0.005 Chagas Cardiomyopathy NA GAD Detail
0.002 Chlamydia Infections NA GAD Detail
0.003 Primary biliary cirrhosis NA BeFree,GAD Detail
<0.001 Cholangitis, Sclerosing NA BeFree Detail
<0.001 cholesteatoma This study suggested that persistent expression of extracellular HMGB-1 and DNA ... BeFree 25416861 Detail
0.001 chondrosarcoma Interleukin-1β induced nuclear factor-κB binds to a disintegrin-like and metallo... BeFree 25760020 Detail
0.002 chorioamnionitis NA GAD Detail
0.201 colitis NA BeFree,CTD_human,RGD Detail
0.123 Colonic Neoplasms NA BeFree,CTD_human,GAD Detail
0.003 colorectal carcinoma Our results, combined with previous studies, suggest that IL10, PSCA, IL1B, and ... BeFree 24557062 Detail
0.003 colorectal carcinoma Accordingly, IL1β and IL23 genes, typically expressed by M1 macrophages, were ex... BeFree 24737547 Detail
0.003 colorectal carcinoma The Th17 cell differentiation simulators IL-1β and IL-6 were also shown in an in... BeFree 24859972 Detail
0.008 Colorectal Neoplasms NA GAD,LHGDN Detail
0.002 common variable immunodeficiency NA GAD Detail
0.002 Connective Tissue Diseases NA GAD Detail
<0.001 Contracture NA BeFree Detail
<0.001 Contracture of joint NA BeFree Detail
0.102 Febrile Convulsions NA BeFree,GAD,LHGDN,RGD Detail
0.002 Coronary Arteriosclerosis NA BeFree Detail
0.017 Coronary heart disease NA BeFree,GAD,LHGDN Detail
<0.001 Coughing NA BeFree Detail
<0.001 craniosynostosis NA BeFree Detail
0.014 Crohn Disease As Th17 cytokines, such as IL-17A, and IL-1 family members, such as IL-36, play ... BeFree,GAD 25299544 Detail
0.014 Crohn Disease IL-1β -511 CC genotype was significantly less present in UC compared to controls... BeFree,GAD 25466956 Detail
<0.001 cryptosporidiosis NA BeFree Detail
0.006 cystic fibrosis Pro-inflammatory alleles of three cytokine genotypes, IL-8, IL-10 and IL-1β, app... BeFree,GAD 24853301 Detail
0.006 cystic fibrosis Here we demonstrate that the degree and quality of the inflammatory response in ... BeFree,GAD 25648527 Detail
0.080 cystitis Antagonizing IL-1β with Anakinra, a rheumatoid arthritis therapeutic, prevented ... BeFree,RGD 25596528 Detail
<0.001 Multi-infarct dementia NA BeFree Detail
0.002 Presenile dementia NA BeFree Detail
<0.001 Senile dementia NA BeFree Detail
0.003 Dementia, Vascular NA BeFree,GAD Detail
<0.001 Dengue Fever Spleen Tyrosine Kinase (Syk) Mediates IL-1β Induction by Primary Human Monocytes... BeFree 26032420 Detail
0.002 Dental Fistula NA GAD Detail
0.002 Dental Occlusion, Traumatic NA GAD Detail
0.007 Dental Plaque NA BeFree,GAD Detail
0.009 Mental Depression TNF-α -308G/A and IL-8 -251T/A were significantly associated with AD and IL-1β +... BeFree,GAD 25315113 Detail
0.082 depressive disorder TNF-α -308G/A and IL-8 -251T/A were significantly associated with AD and IL-1β +... BeFree,RGD 25315113 Detail
0.001 dermatitis NA BeFree Detail
0.132 Dermatitis, Atopic Caspase-1-dependent IL-1β secretion was impaired in monocytes from patients with... BeFree,CTD_human,GAD,LHGDN 24894535 Detail
0.003 contact dermatitis NA BeFree,LHGDN Detail
0.126 dermatomyositis NA BeFree,CTD_human,GAD,LHGDN Detail
0.003 Diabetes Interleukin-1β (IL-1β) is one of the key proinflammatory cytokines that contribu... BeFree 25526310 Detail
0.006 diabetes mellitus Interleukin-1β (IL-1β) is one of the key proinflammatory cytokines that contribu... BeFree,GAD 25526310 Detail
0.200 Diabetes Mellitus, Experimental NA CTD_human,RGD Detail
0.018 Diabetes Mellitus, Insulin-Dependent Type 1 Diabetes (T1D) is an autoimmune disease where local release of cytokines ... BeFree,GAD,LHGDN 24462878 Detail
0.031 Diabetes Mellitus, Non-Insulin-Dependent Our results support the hypothesis that T2D pathology contributes in vivo to inc... BeFree,GAD,LHGDN 25095741 Detail
0.031 Diabetes Mellitus, Non-Insulin-Dependent Non-alcoholic fatty liver disease is prevalent in human obesity and type 2 diabe... BeFree,GAD,LHGDN 25216251 Detail
0.031 Diabetes Mellitus, Non-Insulin-Dependent The expression of GPR109A, NF-kB and IL-1β in peripheral blood leukocytes from p... BeFree,GAD,LHGDN 25361930 Detail
0.031 Diabetes Mellitus, Non-Insulin-Dependent These data provide the first in vivo evidence—using a transgenic mouse model wit... BeFree,GAD,LHGDN 25491100 Detail
0.031 Diabetes Mellitus, Non-Insulin-Dependent Our studies identify a regulatory mechanism controlling diet-induced insulin res... BeFree,GAD,LHGDN 25526310 Detail
0.031 Diabetes Mellitus, Non-Insulin-Dependent In this work, an increased production of IL-1β by MO obtained from patients affe... BeFree,GAD,LHGDN 26095630 Detail
0.088 Diabetic Nephropathy NA BeFree,GAD,LHGDN,RGD Detail
0.080 Diabetic Neuropathies NA RGD Detail
<0.001 diarrhea Increased IL-1β level was predominantly associated with bloating and loose stool... BeFree 25073651 Detail
<0.001 Down syndrome NA BeFree Detail
<0.001 Drug habituation All genes increased in response to initial stress (IL-6: F=3.8; p=0.029; IL-1β: ... BeFree 25683696 Detail
<0.001 Dry Eye Syndromes Hence in this study we determine whether: a) ROS activated NLRP3 inflammasomes m... BeFree 25701684 Detail
0.037 duodenal ulcer NA BeFree,GAD,LHGDN Detail
<0.001 dysentery NA BeFree Detail
<0.001 Amebic colitis NA BeFree Detail
0.012 Dyspepsia NA BeFree,GAD Detail
0.002 dysthymic disorder NA GAD Detail
<0.001 eclampsia The mechanisms may include the following pathways: [TGFB1 or TNFA]-[IL1B]-[pre-e... BeFree 25879409 Detail
0.002 Eczema Caspase-1-dependent IL-1β secretion was impaired in monocytes from patients with... BeFree 24894535 Detail
0.083 encephalitis NA BeFree,GAD,RGD Detail
<0.001 Japanese encephalitis NA BeFree Detail
<0.001 Experimental Autoimmune Encephalomyelitis NA BeFree Detail
<0.001 Leukoencephalitis, Acute Hemorrhagic NA BeFree Detail
<0.001 Bacterial Endocarditis Additionally, we detected a potential relation between interleukin-1β c.315C>T a... BeFree 25299518 Detail
0.015 endometriosis NA BeFree,GAD,LHGDN Detail
0.080 endophthalmitis NA RGD Detail
0.120 Entamoebiasis NA CTD_human Detail
0.080 Enterocolitis NA RGD Detail
0.002 epilepsy Genomic analysis of the interleukin-1β-511 and interleukin-6-174 gene polymorphi... BeFree 25366750 Detail
0.017 Epilepsy, Temporal Lobe Interleukin-1β plays a role in the pathogenesis of mesial temporal lobe epilepsy... BeFree,GAD,LHGDN 25903737 Detail
0.002 Equine Infectious Anemia NA GAD Detail
0.015 Esophageal Neoplasms NA BeFree,GAD Detail
0.008 esophagitis NA BeFree,GAD,LHGDN Detail
0.005 peptic esophagitis NA BeFree,GAD Detail
<0.001 Exanthema NA BeFree Detail
0.082 Fatty Liver NA GAD,RGD Detail
<0.001 fetal alcohol syndrome NA BeFree Detail
0.002 Fetal Diseases NA GAD Detail
0.007 Fetal Membranes, Premature Rupture NA GAD Detail
0.202 Fever NA CTD_human,GAD,RGD Detail
<0.001 Periodic fever NA BeFree Detail
<0.001 fibrosarcoma NA BeFree Detail
0.123 Fibrosis NA CTD_human,LHGDN Detail
<0.001 pathologic fistula NA BeFree Detail
0.003 gallbladder neoplasm NA LHGDN Detail
0.033 gastritis The data from the current study showed that the genotype IL-1B -511T/-31C-IL1-RN... BeFree,GAD,LHGDN 25292060 Detail
0.033 gastritis HP-infected OPN KO mice showed significantly reduced gastritis compared with wil... BeFree,GAD,LHGDN 25867766 Detail
0.151 Gastritis, Atrophic NA BeFree,CTD_human,GAD,LHGDN Detail
0.002 gastroenteritis NA GAD Detail
0.014 gastroesophageal reflux disease IL-1β genetic polymorphisms may take part in the pathophysiology of gastroesopha... BeFree,GAD 25910374 Detail
0.003 Gastrointestinal Diseases NA BeFree,GAD Detail
<0.001 Gastrointestinal Neoplasms NA BeFree Detail
<0.001 Angiolymphoid hyperplasia NA BeFree Detail
0.010 Gingival Diseases NA BeFree Detail
0.005 Gingival Hemorrhage NA GAD Detail
0.005 gingival recession NA BeFree,GAD Detail
0.011 gingivitis NA BeFree,GAD,LHGDN Detail
0.005 glaucoma NA BeFree,GAD,LHGDN Detail
0.005 Glaucoma, Open-Angle NA GAD Detail
0.125 glioblastoma The secretion of IL-1β from glioblastoma cells in turn stimulates the expression... BeFree,CTD_human 24621265 Detail
0.125 glioblastoma Specifically, the ability to produce IL-1 by glioblastoma cells may confer them ... BeFree,CTD_human 25054228 Detail
0.125 glioblastoma Taken together, p38 MAPK-MK2-HuR signalling may enhance the potential of intrins... BeFree,CTD_human 25088200 Detail
0.002 Glioma IL-1 also activated Stat3, a transcription factor crucial in glioma progression. BeFree 25054228 Detail
0.002 Glioma The effect of hBMVEC on C6 glioma sCp expression at the level of transcript and ... BeFree 25311416 Detail
0.121 glomerulonephritis NA BeFree,CTD_human Detail
0.006 IgA glomerulonephritis NA BeFree,GAD Detail
0.080 Glomerulonephritis, Membranoproliferative NA RGD Detail
0.080 membranous glomerulonephritis NA RGD Detail
0.005 Glossitis, Benign Migratory NA BeFree,GAD,LHGDN Detail
<0.001 gonorrhea At baseline, GVL was independently associated with IL-1β after controlling for P... BeFree 26010956 Detail
0.123 gout NA BeFree,CTD_human,GAD Detail
0.013 Graft-vs-Host Disease NA BeFree,GAD Detail
<0.001 chronic granulomatous disease NA BeFree Detail
0.012 Graves Disease NA BeFree,GAD Detail
0.002 Hand Dermatoses NA GAD Detail
<0.001 Sensorineural Hearing Loss (disorder) NA BeFree Detail
<0.001 cardiac arrest These data indicate that IL-1β and IL-6 gene SNPs are associated with SCA compli... BeFree 25595815 Detail
0.005 Heart Diseases NA BeFree,GAD Detail
0.200 Cardiomegaly NA CTD_human,RGD Detail
0.121 Heart failure NA BeFree,CTD_human Detail
0.001 congestive heart failure NA BeFree Detail
0.120 heart valve disease NA CTD_human Detail
0.002 Heartburn NA GAD Detail
0.120 Heat Stroke NA CTD_human Detail
0.005 Hematological Disease NA GAD Detail
0.002 Hemolysis (disorder) NA GAD Detail
0.120 hemolytic-uremic syndrome NA CTD_human Detail
0.002 Hemophilia A NA GAD Detail
0.003 Severe Dengue IL-1β is a potent inflammatory cytokine that is frequently elevated during sever... BeFree,LHGDN 26032420 Detail
0.005 Hemorrhagic Fever with Renal Syndrome NA GAD Detail
<0.001 hepatic veno-occlusive disease NA BeFree Detail
0.006 hepatitis NA BeFree,GAD,LHGDN Detail
<0.001 hepatitis A NA BeFree Detail
0.005 hepatitis B NA BeFree,GAD Detail
<0.001 Hepatitis, Chronic NA BeFree Detail
0.010 hepatitis C NA BeFree,GAD,LHGDN Detail
<0.001 Hepatolenticular Degeneration NA BeFree Detail
<0.001 Hernia NA BeFree Detail
0.003 Histiocytosis, Langerhans-Cell MCPyV infection can trigger precursor LCH cells with BRAF mutation to produce IL... BeFree,LHGDN 25889448 Detail
0.020 HIV Infections During acute HIV infection, circulating Gal-9 was detected as early as 5 days af... BeFree,GAD 24786365 Detail
0.020 HIV Infections In HIV-infected men, semen bacterial load correlated with seven pro-inflammatory... BeFree,GAD 25058515 Detail
0.003 Hodgkin Disease NA BeFree,GAD Detail
<0.001 Huntington disease NA BeFree Detail
0.080 hydronephrosis NA RGD Detail
0.200 Hyperalgesia NA CTD_human,RGD Detail
<0.001 hypercalcemia NA BeFree Detail
<0.001 Hypercholesterolemia NA BeFree Detail
<0.001 Hypercholesterolemia, Familial NA BeFree Detail
0.120 Hyperemia NA CTD_human Detail
0.081 hyperglycemia IL-1β is produced mainly by monocytes (MO), and hyperglycaemia may be able to mo... BeFree,RGD 26095630 Detail
<0.001 hyperinsulinism NA BeFree Detail
<0.001 Hyperlipidemia NA BeFree Detail
0.122 Hypersensitivity NA CTD_human,GAD Detail
0.002 Immediate hypersensitivity NA GAD Detail
0.095 Hypertensive disease NA BeFree,GAD,LHGDN,RGD Detail
0.080 Hypertension, Portal NA BeFree,RGD Detail
0.003 pulmonary hypertension NA BeFree,GAD Detail
0.125 hypoglycemia NA CTD_human,LHGDN Detail
0.120 Hypotension NA CTD_human Detail
<0.001 Immunologic Deficiency Syndromes NA BeFree Detail
0.285 Inflammation NA CTD_human,GAD,LHGDN,RGD Detail
0.019 Inflammatory Bowel Diseases In addition, the cytokines IL-1β, IL-6 and IFN-γ may be potential targets for tr... BeFree,GAD 24776844 Detail
0.019 Inflammatory Bowel Diseases IL-1 SNPs seem to be associated with IBD and could affect the disease severity a... BeFree,GAD 25466956 Detail
<0.001 influenza In 55 subjects with paired exacerbation data, qPCR bacterial load fold change at... BeFree 25103335 Detail
<0.001 insulinoma NA BeFree Detail
0.007 Intervertebral Disk Displacement NA GAD Detail
0.003 irritable bowel syndrome NA BeFree,GAD Detail
0.002 ischemia NA BeFree Detail
0.001 arthropathy NA BeFree Detail
0.120 Kearns-Sayre syndrome NA CTD_human Detail
<0.001 keratitis Expression of IL-8, IL-6 and IL-1β in tears as a main characteristic of the immu... BeFree 25741769 Detail
0.006 keratoconus NA BeFree,GAD,LHGDN Detail
0.003 Kidney Diseases NA BeFree,GAD Detail
0.003 Kidney Failure, Acute NA BeFree,GAD Detail
0.096 Kidney Failure, Chronic NA BeFree,GAD,LHGDN,RGD Detail
0.012 Premature Obstetric Labor NA GAD,LHGDN Detail
0.120 Learning Disorders NA CTD_human Detail
<0.001 Leg Ulcer IL-1β +3954C>T SNP was associated with increased risk of osteonecrosis, elevated... BeFree 25595815 Detail
0.003 Fibroid Tumor NA BeFree,GAD Detail
0.001 leishmaniasis NA BeFree Detail
0.120 Leishmaniasis, Cutaneous NA CTD_human Detail
0.120 Leishmaniasis, Visceral NA BeFree,CTD_human Detail
<0.001 leprosy NA BeFree Detail
0.003 leptospirosis Moreover, our data supports the genetic influence of IL1β, IL12RB1 and CISH gene... BeFree,GAD 25255143 Detail
0.120 Lethargy NA CTD_human Detail
0.002 leukemia NA BeFree Detail
0.004 chronic lymphocytic leukemia NA BeFree,GAD Detail
<0.001 hairy cell leukemia NA BeFree Detail
<0.001 lymphoid leukemia NA BeFree Detail
<0.001 Acute lymphocytic leukemia NA BeFree Detail
<0.001 Acute Megakaryocytic Leukemias NA BeFree Detail
0.009 Leukemia, Myelocytic, Acute NA BeFree,LHGDN Detail
<0.001 myeloid leukemia NA BeFree Detail
0.006 Myeloid Leukemia, Chronic NA BeFree,GAD Detail
<0.001 Leukemia, Myelomonocytic, Chronic NA BeFree Detail
<0.001 acute promyelocytic leukemia NA BeFree Detail
0.001 Leukemia, T-Cell NA BeFree Detail
0.001 Adult T-Cell Lymphoma/Leukemia NA BeFree Detail
0.120 Leukocytosis NA CTD_human Detail
<0.001 Lichen Sclerosus et Atrophicus NA BeFree Detail
0.003 lipodystrophy NA BeFree,GAD Detail
0.013 liver cirrhosis Genetic heterogeneity in the TNFα and IL1β gene promoters influences the risk of... BeFree,GAD 24751829 Detail
0.005 Liver Cirrhosis, Alcoholic NA BeFree,GAD Detail
0.002 Biliary cirrhosis NA GAD Detail
0.120 Liver Cirrhosis, Experimental NA CTD_human Detail
<0.001 Liver diseases NA BeFree Detail
0.083 Alcoholic Liver Diseases NA BeFree,GAD,RGD Detail
0.019 Liver neoplasms In vitro studies using human hepatoma HepG2 cells showed that interleukin-1β dec... BeFree,GAD,LHGDN 25331966 Detail
0.003 Low Back Pain NA BeFree,GAD Detail
0.082 Lung diseases Pro-inflammatory alleles of three cytokine genotypes, IL-8, IL-10 and IL-1β, app... BeFree,RGD 24853301 Detail
0.082 Lung diseases The high-IL-1β expressing genotype was associated with the development of active... BeFree,RGD 25329476 Detail
0.082 Lung diseases Moreover, recent studies suggested that IL-1 participates in the progression of ... BeFree,RGD 25858413 Detail
0.002 Lung Diseases, Fungal NA GAD Detail
0.021 Chronic Obstructive Airway Disease Association between the IL1B, IL1RN polymorphisms and COPD risk: a meta-analysis... BeFree,GAD,LHGDN 25174605 Detail
0.021 Chronic Obstructive Airway Disease Association of interleukin-1β -511C/T promoter polymorphism with COPD risk: a me... BeFree,GAD,LHGDN 25966220 Detail
0.125 Lung Neoplasms NA CTD_human,LHGDN Detail
0.001 Lupus Vulgaris Included in this rubric is the concept that activation of the inflammasome, a mo... BeFree 24992143 Detail
0.002 Lupus Erythematosus, Discoid Included in this rubric is the concept that activation of the inflammasome, a mo... BeFree 24992143 Detail
<0.001 Lupus Erythematosus, Subacute Cutaneous NA BeFree Detail
0.018 Lupus Erythematosus, Systemic Included in this rubric is the concept that activation of the inflammasome, a mo... BeFree,GAD,LHGDN 24992143 Detail
0.018 Lupus Erythematosus, Systemic Furthermore, a significant negative association was found between the T/C genoty... BeFree,GAD,LHGDN 25109676 Detail
0.003 Lyme disease NA LHGDN Detail
0.003 lymphadenitis NA BeFree,GAD Detail
0.002 Lymphatic Diseases NA GAD Detail
0.002 Lymphatic Metastasis NA GAD Detail
0.006 lymphoma NA BeFree,GAD Detail
0.005 Lymphoma, Non-Hodgkin NA GAD,LHGDN Detail
0.120 lymphopenia NA CTD_human Detail
<0.001 Lymphoproliferative Disorders NA BeFree Detail
<0.001 Waldenstrom Macroglobulinemia NA BeFree Detail
0.002 malaria NA BeFree Detail
0.003 Malaria, Cerebral NA BeFree,GAD Detail
0.010 Malaria, Falciparum NA BeFree,GAD,LHGDN Detail
<0.001 Malaria, Vivax NA BeFree Detail
0.065 Malignant neoplasm of stomach The course of gastric cancer following surgery is associated with genetic variat... BeFree,GAD 24557417 Detail
0.065 Malignant neoplasm of stomach The allele flip observed in IL-10 and gastric cancer appears to reflect allelic ... BeFree,GAD 24782608 Detail
0.065 Malignant neoplasm of stomach Wnt5a was overexpressed in gastric cancer tissues, and correlated with monocyte ... BeFree,GAD 24993819 Detail
0.065 Malignant neoplasm of stomach Interactions between pork consumption, CagA status and IL-1B-31 genotypes in gas... BeFree,GAD 25009387 Detail
0.065 Malignant neoplasm of stomach IL-1B-31 locus polymorphism may be associated with gastric cancer susceptibility... BeFree,GAD 25117345 Detail
0.065 Malignant neoplasm of stomach IL-1B (C+3954T) gene polymorphism and susceptibility to gastric cancer in the Ir... BeFree,GAD 25684535 Detail
0.065 Malignant neoplasm of stomach OPN KD gastric cancer cell lines also showed lower proliferative activity and re... BeFree,GAD 25867766 Detail
0.002 Mandibular Diseases NA GAD Detail
0.002 Maxillary Diseases NA GAD Detail
0.003 measles NA BeFree,GAD Detail
0.015 melanoma NA BeFree,GAD,LHGDN Detail
<0.001 melioidosis NA BeFree Detail
0.120 Memory Disorders NA CTD_human Detail
<0.001 Meningitis, Pneumococcal NA BeFree Detail
0.013 Meningococcal Infections NA BeFree,GAD Detail
<0.001 Mesothelioma NA BeFree Detail
<0.001 Metabolic Diseases IL-1β-secreting nucleotide-binding oligomerization domain protein 3 (NLRP3) infl... BeFree 25651569 Detail
0.009 Metaplasia NA GAD Detail
<0.001 mitral valve stenosis NA BeFree Detail
0.004 Monoclonal Gammopathy of Undetermined Significance NA BeFree,LHGDN Detail
<0.001 Monosomy NA BeFree Detail
0.010 Mouth Neoplasms NA GAD,LHGDN Detail
0.006 Mucocutaneous Lymph Node Syndrome NA BeFree,GAD Detail
0.019 multiple myeloma NA BeFree,GAD,LHGDN Detail
0.087 Multiple Organ Failure NA GAD,RGD Detail
0.151 multiple sclerosis The analysis of correlation between IL-1B gene expression and genotyping in mult... BeFree,CTD_human,GAD,LHGDN 24867167 Detail
0.151 multiple sclerosis The serum levels of numerous cytokines (IL-1β, IL-12, IL-6, TNF-α, IFN-γ, IL-4, ... BeFree,CTD_human,GAD,LHGDN 25173940 Detail
0.151 multiple sclerosis One mechanism by which IL-1β might be involved in MS is by inducing pathogenic T... BeFree,CTD_human,GAD,LHGDN 25458313 Detail
<0.001 craniosynostosis To replicate and extend recent findings in a Turkish population of associations ... BeFree 20157068 Detail
<0.001 Chronic sinusitis To replicate and extend recent findings in a Turkish population of associations ... BeFree 20157068 Detail
0.010 Nasal Polyps To replicate and extend recent findings in a Turkish population of associations ... BeFree 20157068 Detail
0.002 mumps NA GAD Detail
0.123 myopathy NA BeFree,CTD_human,LHGDN Detail
0.002 Musculoskeletal Diseases NA GAD Detail
0.001 myasthenia gravis NA BeFree Detail
0.003 Mycobacterium Infections NA BeFree,GAD Detail
<0.001 Mycoplasma Infections NA BeFree Detail
0.001 Mycoses In contrast to the role of IL-1α in neutrophil recruitment, the inflammasome and... BeFree 25629406 Detail
0.219 myocardial infarction NA BeFree,CTD_human,GAD,LHGDN,RGD Detail
0.080 Myocardial Reperfusion Injury NA RGD Detail
<0.001 myocarditis NA BeFree Detail
0.001 myositis NA BeFree Detail
0.010 Nasal Polyps NA BeFree,GAD Detail
0.002 Nasopharyngeal Neoplasms NA GAD Detail
0.120 Necrosis NA CTD_human Detail
0.002 Neoplasm Metastasis Among the female patients presenting metastatic disease and carriers of the TT g... BeFree 24747159 Detail
0.002 Neoplasm Metastasis These results suggest that tested SNPs associated with differential production o... BeFree 26753456 Detail
0.005 Neoplasm Recurrence, Local NA GAD Detail
<0.001 Neoplasms, Experimental NA BeFree Detail
0.002 Pathologic Neovascularization NA GAD Detail
<0.001 nephritis NA BeFree Detail
0.080 nephrosis NA RGD Detail
0.083 nephrotic syndrome NA BeFree,GAD,RGD Detail
0.002 Nerve Degeneration NA GAD Detail
0.002 nervous system disorder NA GAD Detail
0.080 Neuritis, Autoimmune, Experimental NA RGD Detail
0.001 neuroblastoma NA BeFree Detail
<0.001 acoustic neuroma The results of the current study demonstrated that pro-inflammatory cytokines, i... BeFree 25738867 Detail
0.122 neutropenia NA CTD_human,GAD Detail
0.100 obesity We used human adipose tissue biopsies to study the relationship of MAP3K8 expres... BeFree,GAD,RGD 24586913 Detail
0.100 obesity Cytokines of the IL-1 family are important modulators of obesity-induced inflamm... BeFree,GAD,RGD 25182023 Detail
0.100 obesity Furthermore, the administration of IL-1 receptor antagonist to obese mice marked... BeFree,GAD,RGD 25216251 Detail
0.100 obesity Interleukin-1β (IL-1β) is one of the key proinflammatory cytokines that contribu... BeFree,GAD,RGD 25526310 Detail
0.100 obesity Monounsaturated fatty acid-enriched high-fat diets impede adipose NLRP3 inflamma... BeFree,GAD,RGD 25626736 Detail
0.002 Dermatitis, Occupational NA GAD Detail
0.002 Occupational Diseases NA GAD Detail
0.002 oligospermia NA GAD Detail
<0.001 orbit (eye disorders) NA BeFree Detail
0.001 Osteitis NA BeFree Detail
0.003 Osteitis Deformans NA BeFree,GAD Detail
0.256 Degenerative polyarthritis Rabbit cartilage was treated with various concentrations of DHEA in both IL-1β-i... BeFree,CTD_human,GAD,LHGDN,RGD 25065588 Detail
0.256 Degenerative polyarthritis Moreover, the OA-related catabolic factor interleukin-1β induced the expression ... BeFree,CTD_human,GAD,LHGDN,RGD 25158232 Detail
0.256 Degenerative polyarthritis MiR-602 and miR-608 are important posttranscription regulators of SHH expression... BeFree,CTD_human,GAD,LHGDN,RGD 25385442 Detail
0.256 Degenerative polyarthritis In addition, the data also shows that overexpression of HDAC4 not only decreased... BeFree,CTD_human,GAD,LHGDN,RGD 25424126 Detail
0.256 Degenerative polyarthritis Astragalin inhibits IL-1β-induced inflammatory mediators production in human ost... BeFree,CTD_human,GAD,LHGDN,RGD 25637445 Detail
0.256 Degenerative polyarthritis Here, we found that the levels of IL-1β and Cyr61 were higher in RA SF than in o... BeFree,CTD_human,GAD,LHGDN,RGD 25728492 Detail
0.256 Degenerative polyarthritis Gene and protein expression in IL-1β-stimulated human OA chondrocytes/cartilage ... BeFree,CTD_human,GAD,LHGDN,RGD 25917063 Detail
0.256 Degenerative polyarthritis Effect of Bushenhuoxue formula on interleukin-1 beta and discoidin domain recept... BeFree,CTD_human,GAD,LHGDN,RGD 25975052 Detail
0.256 Degenerative polyarthritis Berberine attenuates CCN2-induced IL-1β expression and prevents cartilage degrad... BeFree,CTD_human,GAD,LHGDN,RGD 26344001 Detail
0.256 Degenerative polyarthritis Expression of miR-139 was found to be high in the damaged portion of the OA cart... BeFree,CTD_human,GAD,LHGDN,RGD 26450708 Detail
0.001 Osteoarthritis of hip NA BeFree Detail
0.003 osteomyelitis NA BeFree,GAD Detail
0.086 osteoporosis NA BeFree,GAD,RGD Detail
0.126 Osteoporosis, Postmenopausal NA BeFree,CTD_human,GAD Detail
0.002 osteosarcoma Genetic polymorphisms of interleukin-1 beta and osteosarcoma risk. BeFree 24878968 Detail
0.087 otitis media This study was designed to understand the contribution of the inflammasome and I... BeFree,GAD,RGD 24652041 Detail
0.003 Otitis Media with Effusion NA BeFree,LHGDN Detail
0.004 ovarian carcinoma NA BeFree Detail
<0.001 Ovarian Diseases NA BeFree Detail
0.002 Pain, Postoperative NA GAD Detail
0.005 Pancreatic Neoplasm NA BeFree,GAD Detail
0.086 pancreatitis Administration of MSCs alone significantly reduced pancreatic injury and inflamm... BeFree,GAD,LHGDN,RGD 25120736 Detail
0.107 Parkinson disease Pro and anti-inflammatory cytokines did not show significant differences between... BeFree,GAD,LHGDN,RGD 25329911 Detail
0.003 Pemphigoid, Benign Mucous Membrane NA LHGDN Detail
0.002 bullous pemphigoid NA GAD Detail
0.007 pemphigus NA GAD Detail
0.002 pemphigus vulgaris NA GAD Detail
0.145 Peptic Ulcer NA BeFree,CTD_human,GAD Detail
<0.001 Periapical Diseases NA BeFree Detail
0.003 periapical periodontitis NA BeFree,GAD Detail
0.006 familial Mediterranean fever The absence of spontaneous IL-1β release by PBMCs reflects no constitutive activ... BeFree,GAD 25025954 Detail
0.029 Periodontal Diseases NA BeFree,GAD Detail
0.010 Periodontal Pocket NA BeFree,GAD Detail
0.178 periodontitis A meta-analysis of the three populations supported the association between the I... BeFree,GAD,LHGDN,RGD 24690098 Detail
0.013 Periodontitis, Juvenile NA BeFree,GAD Detail
0.001 peritonitis NA BeFree Detail
<0.001 Polymorphous light eruption NA BeFree Detail
<0.001 pituitary adenoma NA BeFree Detail
0.002 Pituitary Diseases NA BeFree Detail
<0.001 plasmacytoma NA BeFree Detail
0.002 Pleural effusion disorder NA GAD Detail
0.200 pleurisy NA CTD_human,RGD Detail
<0.001 pleuropneumonia NA BeFree Detail
0.003 Pneumococcal Infections NA BeFree,GAD Detail
0.005 pneumoconiosis NA GAD Detail
0.208 pneumonia TNB instillations in IL-1R null mice demonstrated the critical role of IL-1β in ... BeFree,CTD_human,LHGDN,RGD 25179214 Detail
0.006 polycystic ovary syndrome The studies involved the following polymorphisms: TNF-α -308G > A, TNF-α -805C>T... BeFree,GAD 25690158 Detail
<0.001 polymyalgia rheumatica NA BeFree Detail
0.005 Postoperative Complications NA GAD Detail
0.005 pre-eclampsia NA GAD Detail
0.015 Precancerous Conditions NA BeFree,GAD Detail
0.002 Pregnancy Complications, Hematologic NA GAD Detail
<0.001 ectopic pregnancy NA BeFree Detail
<0.001 Pruritus NA BeFree Detail
<0.001 Pseudorabies NA BeFree Detail
0.128 psoriasis Our results indicate that one of the early steps of psoriasis pathogenesis may b... BeFree,CTD_human,GAD 24419088 Detail
0.002 pterygium NA GAD Detail
0.002 Puerperal Disorders NA GAD Detail
<0.001 pulmonary edema The protective effects of bLF against hyperoxia were further confirmed by signif... BeFree 24842100 Detail
<0.001 pulmonary emphysema In vitro studies revealed that Thal decreased 1) the expression of IL-1β and IL-... BeFree 25749497 Detail
0.206 pulmonary fibrosis NA BeFree,CTD_human,GAD,RGD Detail
0.003 purpura NA LHGDN Detail
0.002 Henoch-Schoenlein purpura NA GAD Detail
0.002 Q fever NA GAD Detail
<0.001 Radicular Cyst NA BeFree Detail
<0.001 Raynaud disease NA BeFree Detail
0.002 kidney failure NA BeFree Detail
0.120 Reperfusion Injury NA CTD_human Detail
<0.001 Respiratory Distress Syndrome, Newborn NA BeFree Detail
0.004 Respiratory Distress Syndrome, Adult NA BeFree,LHGDN Detail
0.002 Respiratory Hypersensitivity NA GAD Detail
0.003 Respiratory Syncytial Virus Infections NA BeFree,GAD Detail
0.005 Respiratory Tract Infections NA GAD,LHGDN Detail
<0.001 retinal degeneration Our work demonstrates that in the context of an established animal model for ocu... BeFree 25522272 Detail
<0.001 Retinal Diseases IL-1β +3954C>T SNP was associated with increased risk of osteonecrosis, elevated... BeFree 25595815 Detail
0.082 retinal vein occlusion NA GAD,RGD Detail
0.082 retinopathy of prematurity NA GAD,RGD Detail
<0.001 Retroviridae Infections NA BeFree Detail
0.005 Rheumatism NA BeFree,GAD Detail
<0.001 rheumatic fever NA BeFree Detail
<0.001 Rheumatoid Nodule NA BeFree Detail
0.085 rhinitis NA GAD,RGD Detail
<0.001 Rift Valley fever NA BeFree Detail
0.003 root resorption NA BeFree,GAD Detail
0.002 rubella NA GAD Detail
0.003 Salmonella infections Here, we demonstrate that neutrophils, typically viewed as cellular targets of I... BeFree,GAD 25043180 Detail
0.010 sarcoidosis NA BeFree,GAD,LHGDN Detail
0.003 Sarcoidosis, Pulmonary NA BeFree,GAD Detail
<0.001 Kaposi sarcoma NA BeFree Detail
0.147 schizophrenia Moreover, recent studies suggested that IL-1 participates in the progression of ... BeFree,CTD_human,GAD,LHGDN 25858413 Detail
0.019 systemic scleroderma Immunohistochemical analysis showed stronger staining of NLRP3 and IL-1β cytopla... BeFree,GAD,LHGDN 25739168 Detail
0.008 Sclerosis NA GAD,LHGDN Detail
<0.001 scrub typhus NA BeFree Detail
0.204 Seizures These data are the first to demonstrate that the inflammatory response induced b... BeFree,CTD_human,LHGDN,RGD 25903737 Detail
0.005 Shock NA GAD,LHGDN Detail
0.080 Shock, Hemorrhagic NA RGD Detail
0.005 Septic Shock NA GAD,LHGDN Detail
<0.001 Shy-Drager Syndrome NA BeFree Detail
0.130 silicosis NA BeFree,CTD_human,GAD,LHGDN Detail
0.005 sinusitis NA BeFree,GAD Detail
0.125 Dermatologic disorders IL-33 is a novel IL-1 family member with a putative role in inflammatory skin di... BeFree,CTD_human,GAD 25739051 Detail
<0.001 Skin lesion As Th17 cytokines, such as IL-17A, and IL-1 family members, such as IL-36, play ... BeFree 25299544 Detail
0.003 Skin Neoplasms NA BeFree,GAD Detail
0.002 Skin Ulcer NA GAD Detail
<0.001 smallpox NA BeFree Detail
0.005 Spinal Diseases NA GAD Detail
0.022 ankylosing spondylitis NA BeFree,GAD,LHGDN Detail
0.080 status epilepticus NA BeFree,RGD Detail
0.023 Stomach Diseases NA BeFree,GAD Detail
0.241 Stomach Neoplasms NA BeFree,CTD_human,GAD,LHGDN Detail
0.146 gastric ulcer NA BeFree,CTD_human,GAD,LHGDN Detail
0.003 stomatitis NA LHGDN Detail
0.017 aphthous stomatitis NA GAD,LHGDN Detail
0.002 Streptococcal Infections NA GAD Detail
<0.001 post-traumatic stress disorder NA BeFree Detail
<0.001 Stress, Psychological NA BeFree Detail
0.146 Cerebrovascular accident The association between three promoter polymorphisms of IL-1 and stroke: a meta-... BeFree,CTD_human,GAD,LHGDN 25917615 Detail
0.006 Subarachnoid Hemorrhage NA BeFree,GAD Detail
0.006 sudden infant death syndrome NA BeFree,GAD Detail
<0.001 Superinfection NA BeFree Detail
0.003 synovial sarcoma NA BeFree,LHGDN Detail
0.001 synovitis NA BeFree Detail
<0.001 Testicular Neoplasms NA BeFree Detail
<0.001 tetanus NA BeFree Detail
0.002 Thinness NA GAD Detail
0.002 Thoracic Neoplasms NA GAD Detail
0.001 thromboangiitis obliterans NA BeFree Detail
0.003 thrombosis NA LHGDN Detail
<0.001 thymoma NA BeFree Detail
0.005 Thyroid Diseases NA BeFree,GAD Detail
0.120 Thyroid Neoplasm NA CTD_human Detail
0.003 Gilles de la Tourette syndrome NA BeFree,GAD Detail
0.003 trachoma NA BeFree,GAD Detail
0.003 Chagas disease We conclude that caspase-1/ASC inflammasomes play a significant role in the acti... BeFree,GAD 25372293 Detail
0.019 tuberculosis Allele-specific induction of IL-1β expression by C/EBPβ and PU.1 contributes to ... BeFree,GAD,LHGDN 25329476 Detail
0.019 tuberculosis Most of the host components involved in TB inflammation, including cytokines (in... BeFree,GAD,LHGDN 25453228 Detail
0.019 tuberculosis Among our most significant findings were SNPs in TICAM2 (P = 3.6 × 10(-6)) and I... BeFree,GAD,LHGDN 25521228 Detail
0.019 tuberculosis IL-1β+3953C/T, -511T/C and IL-6 -174C/G polymorphisms in association with tuberc... BeFree,GAD,LHGDN 26169021 Detail
0.004 Tuberculosis, Pulmonary 1,25(OH)2D3 significantly suppressed all the CFA induced pro-inflammatory cytoki... BeFree,GAD 25194676 Detail
0.004 Tuberculosis, Pulmonary In this study we aimed to examine the possible association between the variable ... BeFree,GAD 25530139 Detail
<0.001 typhoid fever NA BeFree Detail
0.017 Ulcer NA GAD Detail
0.002 Unipolar Depression The IL1B genotype interacted with contextual stress such that children homozygou... BeFree 25422961 Detail
0.003 Erythema NA BeFree,GAD Detail
0.002 uremia NA GAD Detail
0.080 ureteral obstruction NA BeFree,RGD Detail
0.080 urinary tract infection NA BeFree,RGD Detail
0.121 urticaria NA BeFree,CTD_human Detail
0.002 Uterine Diseases NA GAD Detail
<0.001 Uterine Fibroids NA BeFree Detail
0.002 Uterine Neoplasms NA GAD Detail
0.081 uveitis These results suggest that IL-1β is an important mediator in the pathogenesis of... BeFree,RGD 25017970 Detail
0.081 uveitis New cytokine inhibitors targeting IL-1 and IL-6 appear to be effective especiall... BeFree,RGD 26487500 Detail
<0.001 Uveomeningoencephalitic Syndrome NA BeFree Detail
0.080 varicocele NA RGD Detail
<0.001 Vascular Diseases This could reveal additional potential anti-IL-1β therapeutic targets and provid... BeFree 26269588 Detail
0.009 vasculitis NA BeFree,GAD,LHGDN Detail
0.080 Venous Thrombosis NA RGD Detail
0.002 Viremia NA GAD Detail
0.002 Virus Diseases NA BeFree Detail
<0.001 vitiligo Association of neuropeptide Y (NPY), interleukin-1B (IL1B) genetic variants and ... BeFree 25221996 Detail
0.002 vulvovaginitis NA GAD Detail
0.002 Wasting Syndrome NA GAD Detail
0.083 Helicobacter Infections NA GAD,LHGDN Detail
0.002 B-Cell Lymphomas NA GAD Detail
0.003 diffuse large B-cell lymphoma NA BeFree,GAD Detail
0.003 T-Cell Lymphoma NA BeFree,GAD Detail
0.006 Tooth Loss NA BeFree,GAD Detail
0.002 Peripheral Vascular Diseases NA GAD Detail
<0.001 severe combined immunodeficiency NA BeFree Detail
0.002 Bronchial Hyperreactivity NA GAD Detail
0.014 bacterial vaginosis The levels of interleukin-1α (IL-1α), IL-1β, IL-6, IL-12(p70), and IL-8 were ele... BeFree,GAD,LHGDN 25761460 Detail
0.004 gestational diabetes Thus, the aims of this study were (i) to determine whether GSK3 is increased in ... BeFree,LHGDN 25541965 Detail
0.002 Adult-Onset Still Disease NA GAD Detail
<0.001 Diffuse cutaneous leishmaniasis NA BeFree Detail
<0.001 Neurofibrillary degeneration (morphologic abnormality) NA BeFree Detail
<0.001 POEMS syndrome NA BeFree Detail
<0.001 Polyendocrinopathies, Autoimmune Our previous study showed that PGA activates the human macrophage cell line THP-... BeFree 26195551 Detail
0.002 Arthritis, Reactive NA GAD Detail
<0.001 Meningitis, Bacterial NA BeFree Detail
<0.001 Restrictive lung disease NA BeFree Detail
0.003 Liver failure NA BeFree,GAD Detail
<0.001 pyoderma gangrenosum IL-1 may be involved in clinical manifestation of certain (genetic) forms of PG. BeFree 24898196 Detail
0.121 polymyositis NA BeFree,CTD_human Detail
<0.001 acute leukemia The aim of this study was to investigate the mannose-binding lectin 2 (MBL-2), i... BeFree 24819208 Detail
<0.001 Acute appendicitis NOS (disorder) Finally, we confirmed the involvement of the pro-inflammatory cytokines IL-1β an... BeFree 24336024 Detail
0.002 Chronic gastritis NA BeFree Detail
<0.001 Hamman-Rich syndrome NA BeFree Detail
<0.001 Hypokinesia NA BeFree Detail
<0.001 Chronic sinusitis NA BeFree Detail
0.005 Pancreatitis, Chronic NA BeFree,GAD,LHGDN Detail
0.003 Epstein-Barr Virus Infections The levels of inflammatory cytokines IL-6, IL-8, IL-1β and TNF-α in the HNE2 cel... BeFree,GAD 25891128 Detail
0.002 Migraine Disorders NA GAD Detail
0.080 sciatic neuropathy NA RGD Detail
0.002 Lumbar spondylosis NA GAD Detail
<0.001 Active tuberculosis The high-IL-1β expressing genotype was associated with the development of active... BeFree 25329476 Detail
<0.001 Atrophic condition of skin NA BeFree Detail
0.026 Premature Birth NA GAD,LHGDN Detail
0.121 Myocardial Ischemia Coronary arteries from patients with ischemic heart disease express large amount... BeFree,CTD_human 26269588 Detail
<0.001 Adenocarcinoma of lung (disorder) NA BeFree Detail
0.001 esophageal carcinoma NA BeFree Detail
<0.001 Joint swelling NA BeFree Detail
<0.001 Pustular psoriasis NA BeFree Detail
<0.001 Malignant neoplasm of mouth NA BeFree Detail
<0.001 Malignant neoplasm of pharynx NA BeFree Detail
<0.001 Malignant neoplasm of gallbladder NA BeFree Detail
<0.001 Secondary malignant neoplasm of lung NA BeFree Detail
<0.001 Corneal pannus NA BeFree Detail
<0.001 Middle Ear Cholesteatoma NA BeFree Detail
<0.001 allergic asthma Whereas IL-1β promotes Th1 and Th17 responses and gastric immunopathology, IL-18... BeFree 26214524 Detail
<0.001 Peritoneal adhesion NA BeFree Detail
0.007 Intervertebral Disc Degeneration We investigated whether expression of xylosyltransferase-1 (XT-1), a key enzyme ... BeFree,GAD 25476526 Detail
<0.001 adrenoleukodystrophy NA BeFree Detail
<0.001 iron deficiency anemia NA BeFree Detail
<0.001 Prion Diseases NA BeFree Detail
<0.001 Liver Failure, Acute The role of AIM2 in affecting pro-inflammatory activation of Kupffer cells by in... BeFree 25562161 Detail
0.120 Mitochondrial Myopathies NA CTD_human Detail
0.120 MELAS syndrome NA CTD_human Detail
0.120 MERRF syndrome NA CTD_human Detail
0.120 chronic progressive external ophthalmoplegia NA CTD_human Detail
0.003 Dermatitis, Allergic Contact NA BeFree,GAD Detail
0.005 Dermatitis, Irritant NA BeFree,GAD Detail
<0.001 hidradenitis suppurativa In patients with a pyoderma gangrenosum, acne, and suppurative hidradenitis synd... BeFree 24898196 Detail
0.002 Aneurysm, Ruptured NA GAD Detail
0.012 Aortic Aneurysm, Abdominal NA BeFree,GAD Detail
<0.001 Aortic Aneurysm, Thoracic NA BeFree Detail
0.002 Tumor Progression Mounting evidence supports that chronic inflammation (such as chronic overactiva... BeFree 25054228 Detail
<0.001 Diabetes, Autoimmune NA BeFree Detail
<0.001 Lung Diseases, Interstitial NA BeFree Detail
0.012 Periodontal Attachment Loss NA BeFree,GAD Detail
0.006 Lichen Planus, Oral NA BeFree,GAD Detail
<0.001 hepatoblastoma NA BeFree Detail
<0.001 Follicular thyroid carcinoma NA BeFree Detail
0.002 Carcinoma, Signet Ring Cell NA GAD Detail
<0.001 cholangiocarcinoma NA BeFree Detail
<0.001 Cervical Intraepithelial Neoplasia Moreover, the T-allele of IL-1β showed increased susceptibility for CIN [OR = 3.... BeFree 25893807 Detail
<0.001 Neuroendocrine Tumors NA BeFree Detail
<0.001 Lip and oral cavity carcinoma NA BeFree Detail
<0.001 Reactive systemic amyloidosis NA BeFree Detail
<0.001 Adult type dermatomyositis NA BeFree Detail
0.005 Lytic lesion NA GAD Detail
<0.001 mesangial proliferative glomerulonephritis NA BeFree Detail
<0.001 Effects of heat NA BeFree Detail
<0.001 Premature aging syndrome NA BeFree Detail
0.001 Memory impairment We showed that SIRT1 is reduced with the aging of microglia and that microglial ... BeFree 25589773 Detail
0.002 pancreatic carcinoma NA BeFree Detail
<0.001 Renal interstitial fibrosis NA BeFree Detail
<0.001 Age-related cognitive decline NA BeFree Detail
<0.001 Colitis, Collagenous NA BeFree Detail
<0.001 Hereditary pancreatitis NA BeFree Detail
<0.001 Candidiasis of the esophagus NA BeFree Detail
<0.001 Fibrosis, Liver NA BeFree Detail
<0.001 Iron deficiency NA BeFree Detail
0.003 Hepatitis, Autoimmune NA BeFree,GAD Detail
<0.001 Pulmonary congestion The consequence of VILI by H&E stain showed inducing lung congestion and increas... BeFree 25815839 Detail
0.003 Biliary calculi NA LHGDN Detail
0.002 coronary stenosis NA GAD Detail
0.005 age related macular degeneration NA BeFree,GAD Detail
0.080 Parkinsonian Disorders NA RGD Detail
0.083 Acute Lung Injury NA LHGDN,RGD Detail
0.002 Mucosa-Associated Lymphoid Tissue Lymphoma NA GAD Detail
0.003 Disease Progression NA LHGDN Detail
0.003 Hyperoxia NA LHGDN Detail
0.007 Parasitemia NA GAD Detail
0.003 Systemic Inflammatory Response Syndrome NA BeFree,GAD Detail
<0.001 nephropathia epidemica NA BeFree Detail
0.003 Carcinoma, Lewis Lung NA BeFree,LHGDN Detail
<0.001 Epithelial hyperplasia of skin NA BeFree Detail
<0.001 Dermatomyositis, Childhood Type NA BeFree Detail
<0.001 Chronic arthritis NA BeFree Detail
<0.001 Osteoarthritis of the hand NA BeFree Detail
<0.001 Degeneration of lumbar intervertebral disc NA BeFree Detail
<0.001 Proliferative synovitis NA BeFree Detail
<0.001 Acute upper respiratory infection NA BeFree Detail
0.033 Chronic Periodontitis This study validated the influence of IL-1 genetic factors on the severity of ch... BeFree,GAD,LHGDN 24690098 Detail
0.033 Chronic Periodontitis In conclusion, the present study suggests a strong association of the TT genotyp... BeFree,GAD,LHGDN 25252591 Detail
0.033 Chronic Periodontitis In the study population examined, the SNP in the IL1B gene (+3954) and VNTR poly... BeFree,GAD,LHGDN 25710474 Detail
<0.001 Erosive esophagitis Genetic polymorphisms of CYP2C19 and IL1B have no influence on esomeprazole trea... BeFree 25910560 Detail
<0.001 Eosinophilic colitis NA BeFree Detail
<0.001 Acute peritonitis NA BeFree Detail
0.081 Pancreatitis, Acute Necrotizing Compared with the ANP group, the mRNA and protein expression of IREl a and the p... BeFree,RGD 26427114 Detail
0.001 Muckle-Wells syndrome NA BeFree Detail
<0.001 Hemodialysis-associated amyloidosis NA BeFree Detail
<0.001 5,10-Methylenetetrahydrofolate reductase deficiency NA BeFree Detail
0.001 Endometrioma NA BeFree Detail
<0.001 Coinfection NA BeFree Detail
<0.001 Tuberculosis of intestines NA BeFree Detail
<0.001 Familial Alzheimer Disease (FAD) NA BeFree Detail
0.003 Invasive Pulmonary Aspergillosis NA BeFree,LHGDN Detail
<0.001 Infection by Candida albicans NA BeFree Detail
0.002 Behavioral tic NA GAD Detail
<0.001 Stage II Colon Cancer NA BeFree Detail
<0.001 Malignant neoplasm of stomach stage IV NA BeFree Detail
<0.001 Metastatic osteosarcoma A2M and its interactive proteins, such as IL1B, LRP1 and PDGF may be candidate t... BeFree 25605179 Detail
0.001 gastric adenocarcinoma NA BeFree Detail
<0.001 Metastatic melanoma NA BeFree Detail
<0.001 Philadelphia chromosome positive chronic myelogenous leukemia NA BeFree Detail
<0.001 Squamous cell carcinoma of esophagus NA BeFree Detail
<0.001 Adenocarcinoma Of Esophagus NA BeFree Detail
<0.001 Solid tumour NA BeFree Detail
<0.001 stage, gastric cancer NA BeFree Detail
<0.001 Adenocarcinoma of pancreas NA BeFree Detail
<0.001 Disease caused by Shigella dysenteriae NA BeFree Detail
<0.001 Obesity, Abdominal NA BeFree Detail
0.120 Arsenic Poisoning NA CTD_human Detail
<0.001 Dryness of eye Hence in this study we determine whether: a) ROS activated NLRP3 inflammasomes m... BeFree 25701684 Detail
0.003 Restenosis NA BeFree,GAD Detail
<0.001 Bleeding ulcer NA BeFree Detail
<0.001 Healing ulcer NA BeFree Detail
0.002 Superficial ulcer NA BeFree Detail
0.200 Inflammatory disease of mucous membrane NA CTD_human,RGD Detail
0.001 Senile Plaques Interleukin-1β mediated amyloid plaque clearance is independent of CCR2 signalin... BeFree 24874542 Detail
0.001 Tumor necrosis NA BeFree Detail
0.012 Atrophic NA GAD Detail
<0.001 Arteriovenous hemangioma NA BeFree Detail
<0.001 Adenocarcinoma of colon NA BeFree Detail
<0.001 Impaired cognition SIRT1 deficiency in microglia contributes to cognitive decline in aging and neur... BeFree 25589773 Detail
0.012 Thyroid associated opthalmopathies Interleukin-1 beta/IL-1B/(2.3-fold) and interleukin-6/IL-6/(2.4-fold) were upreg... BeFree,GAD 25135760 Detail
0.003 Glaucoma, Primary Open Angle NA BeFree,GAD Detail
<0.001 Q fever endocarditis NA BeFree Detail
<0.001 Internal Carotid Artery Stenosis We found that interleukin (IL) 6 (IL-6), IL-1β, monocyte chemoattractant protein... BeFree 25441669 Detail
<0.001 Congenital neutropenia NA BeFree Detail
<0.001 Chronic liver disease NA BeFree Detail
0.002 Complications of Diabetes Mellitus NA GAD Detail
<0.001 Deficiency of mevalonate kinase NA BeFree Detail
0.002 Familial cold urticaria NA BeFree Detail
<0.001 Microscopic Polyangiitis NA BeFree Detail
0.080 Enterocolitis, Neutropenic NA RGD Detail
<0.001 MRSA - Methicillin resistant Staphylococcus aureus infection NA BeFree Detail
0.120 HIV Wasting Syndrome NA CTD_human Detail
0.002 Malignant neoplasm of liver NA GAD Detail
<0.001 malignant mesothelioma NA BeFree Detail
0.002 Malignant neoplasm of pancreas NA BeFree Detail
<0.001 Cervical intraepithelial neoplasia grade 2 NA BeFree Detail
<0.001 juvenile myelomonocytic leukemia NA BeFree Detail
0.010 Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site OPN KD gastric cancer cell lines also showed lower proliferative activity and re... BeFree 25867766 Detail
0.010 Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site Genotypes of IL-1β (-511,-31), IL-1RN gene polymorphisms and HP status of the pa... BeFree 25910374 Detail
0.010 Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site Inflammasome activation and caspase-1-dependent (CASP1-dependent) processing and... BeFree 26214524 Detail
<0.001 Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site NA BeFree Detail
0.003 Malignant neoplasm of vulva NA BeFree,GAD Detail
<0.001 dengue shock syndrome NA BeFree Detail
0.018 Malignant neoplasm of prostate Both IL-1β and IFNβ may be new biomarkers to distinguish high-risk/low-risk pati... BeFree,GAD 25075566 Detail
0.018 Malignant neoplasm of prostate IL-1β induces p62/SQSTM1 and represses androgen receptor expression in prostate ... BeFree,GAD 25103771 Detail
0.018 Malignant neoplasm of prostate Genetic polymorphism of interleukin-1A (IL-1A), IL-1B, and IL-1 receptor antagon... BeFree,GAD 25374200 Detail
0.018 Malignant neoplasm of prostate Investigation of Interleukin-1β Polymorphisms in Prostate Cancer. BeFree,GAD 26504029 Detail
0.018 Malignant neoplasm of prostate Association of IL-1β and IL-10 Polymorphisms with Prostate Cancer Risk and Grade... BeFree,GAD 26753456 Detail
0.005 Hematologic Neoplasms NA BeFree,GAD Detail
0.080 Endotoxemia NA RGD Detail
<0.001 Hereditary hemochromatosis NA BeFree Detail
0.005 nephrolithiasis NA BeFree,GAD,LHGDN Detail
0.002 Postoperative infection NA GAD Detail
0.005 Atopy NA GAD Detail
0.003 multiple system atrophy NA BeFree,GAD Detail
0.009 Immune thrombocytopenic purpura NA GAD Detail
<0.001 Sarcoid myopathy NA BeFree Detail
<0.001 Primary immune deficiency disorder NA BeFree Detail
0.001 Early onset periodontitis NA BeFree Detail
<0.001 Non-alcoholic Fatty Liver Disease In the liver samples of patients with NAFLD, inflammasome components were signif... BeFree 24861026 Detail
<0.001 Non-alcoholic Fatty Liver Disease Non-alcoholic fatty liver disease is prevalent in human obesity and type 2 diabe... BeFree 25216251 Detail
<0.001 Idiopathic crescentic glomerulonephritis NA BeFree Detail
0.080 Chronic Kidney Insufficiency NA RGD Detail
0.080 Anti-Glomerular Basement Membrane Disease NA RGD Detail
<0.001 Actinic prurigo NA BeFree Detail
<0.001 Chronic small plaque psoriasis As Th17 cytokines, such as IL-17A, and IL-1 family members, such as IL-36, play ... BeFree 25299544 Detail
0.002 Chronic Infantile Neurological, Cutaneous, and Articular Syndrome However, epiphyseal overgrowth in NOMID is resistant to anti-IL-1 therapy and ma... BeFree 25302486 Detail
<0.001 Idiopathic osteoarthritis NA BeFree Detail
<0.001 Osteoarthritis of distal interphalangeal joint NA BeFree Detail
0.014 Osteoarthritis, Knee NA BeFree,GAD,LHGDN Detail
0.001 lupus erythematosus Included in this rubric is the concept that activation of the inflammasome, a mo... BeFree 24992143 Detail
<0.001 Chronic multifocal osteomyelitis Deregulation of the IL-1β axis in chronic recurrent multifocal osteomyelitis. BeFree 25061439 Detail
0.002 Fever symptoms (finding) NA GAD Detail
<0.001 Arthritis by pattern of joint involvement NA BeFree Detail
<0.001 Ichthyosis bullosa of Siemens NA BeFree Detail
<0.001 Fatigue - symptom NA BeFree Detail
<0.001 neuropathy NA BeFree Detail
0.003 urolithiasis NA BeFree,GAD Detail
0.002 Dermatitis and eczema NA GAD Detail
<0.001 Alzheimer Disease, Late Onset Thus, circadian rhythms, nest construction, IL-1β and TNF-α, and glial fibrillar... BeFree 25159669 Detail
0.010 dementia NA BeFree,GAD,LHGDN Detail
0.081 Necrotizing Enterocolitis NA BeFree,RGD Detail
<0.001 Chronic active hepatitis NA BeFree Detail
0.083 Sleep Apnea, Obstructive NA BeFree,GAD,RGD Detail
<0.001 Recurrent tumor NA BeFree Detail
<0.001 Granulomatosis NA BeFree Detail
0.006 Metabolic syndrome X NA BeFree,GAD Detail
<0.001 Opiate Addiction NA BeFree Detail
<0.001 Neurodegenerative Disorders NA BeFree Detail
0.020 Hepatitis B, Chronic NA BeFree,GAD,LHGDN Detail
0.017 Hepatitis C, Chronic NA BeFree,GAD,LHGDN Detail
<0.001 Schnitzler syndrome NA BeFree Detail
0.005 Mood Disorders NA BeFree,GAD Detail
0.018 Malignant neoplasm of esophagus NA BeFree,GAD Detail
<0.001 Subacromial bursitis NA BeFree Detail
<0.001 X-Linked Lymphoproliferative Disorder NA BeFree Detail
<0.001 Thyroid carcinoma NA BeFree Detail
<0.001 Malignant glioma Aberrant expression of interleukin-1β and inflammasome activation in human malig... BeFree 25054228 Detail
<0.001 primary sclerosing cholangitis NA BeFree Detail
<0.001 Minor oral aphthous ulceration NA BeFree Detail
0.002 Osteosarcoma of bone Genetic polymorphisms of interleukin-1 beta and osteosarcoma risk. BeFree 24878968 Detail
<0.001 Severe depression Also in line with hypotheses, the -511C allele in IL1β, previously associated wi... BeFree 25596176 Detail
<0.001 Carcinoma of larynx NA BeFree Detail
0.010 Carcinogenesis Emerging evidence has demonstrated that polymorphisms of interleukin-1 (IL-1) ma... BeFree 24862933 Detail
0.010 Carcinogenesis Interleukin-1 beta (IL-1B) is crucially involved in osteosarcoma carcinogenesis. BeFree 24878968 Detail
0.010 Carcinogenesis IL-1β-mediated repression of microRNA-101 is crucial for inflammation-promoted l... BeFree 24958470 Detail
0.010 Carcinogenesis Mounting evidence supports that chronic inflammation (such as chronic overactiva... BeFree 25054228 Detail
<0.001 Chemical Carcinogenesis NA BeFree Detail
<0.001 Leukemogenesis NA BeFree Detail
<0.001 monocytic leukemia NA BeFree Detail
0.004 prostate carcinoma Both IL-1β and IFNβ may be new biomarkers to distinguish high-risk/low-risk pati... BeFree 25075566 Detail
0.004 prostate carcinoma IL-1β induces p62/SQSTM1 and represses androgen receptor expression in prostate ... BeFree 25103771 Detail
0.004 prostate carcinoma Genetic polymorphism of interleukin-1A (IL-1A), IL-1B, and IL-1 receptor antagon... BeFree 25374200 Detail
0.004 prostate carcinoma Investigation of Interleukin-1β Polymorphisms in Prostate Cancer. BeFree 26504029 Detail
0.004 prostate carcinoma Association of IL-1β and IL-10 Polymorphisms with Prostate Cancer Risk and Grade... BeFree 26753456 Detail
0.002 Lung Diseases, Obstructive NA GAD Detail
<0.001 toxic shock syndrome NA BeFree Detail
0.002 Choroidal Neovascularization NA GAD Detail
0.120 Manganese Poisoning NA CTD_human Detail
<0.001 CARCINOMA OF VULVA NA BeFree Detail
0.003 Hashimoto Disease Interleukin 1 beta (IL1beta) gene polymorphisms (SNP-511 and SNP+3953) in Hashim... BeFree,GAD 25310146 Detail
<0.001 Gastro-esophageal reflux disease with esophagitis NA BeFree Detail
0.001 Epithelial ovarian cancer NA BeFree Detail
0.006 breast carcinoma Here, we identified the impact of TNF-α and IL-1β on the inflammatory phenotype ... BeFree 25928089 Detail
<0.001 iron loading anemia NA BeFree Detail
<0.001 inflammatory joint disease NA BeFree Detail
<0.001 CNS metastases New cytokine inhibitors targeting IL-1 and IL-6 appear to be effective especiall... BeFree 26487500 Detail
<0.001 Secondary malignant neoplasm of lymph node NA BeFree Detail
0.002 Pregnancy loss NA GAD Detail
0.002 colon carcinoma NA BeFree Detail
0.028 stomach carcinoma The course of gastric cancer following surgery is associated with genetic variat... BeFree,GAD 24557417 Detail
0.028 stomach carcinoma The allele flip observed in IL-10 and gastric cancer appears to reflect allelic ... BeFree,GAD 24782608 Detail
0.028 stomach carcinoma Wnt5a was overexpressed in gastric cancer tissues, and correlated with monocyte ... BeFree,GAD 24993819 Detail
0.028 stomach carcinoma Interactions between pork consumption, CagA status and IL-1B-31 genotypes in gas... BeFree,GAD 25009387 Detail
0.028 stomach carcinoma IL-1B-31 locus polymorphism may be associated with gastric cancer susceptibility... BeFree,GAD 25117345 Detail
0.028 stomach carcinoma IL-1B (C+3954T) gene polymorphism and susceptibility to gastric cancer in the Ir... BeFree,GAD 25684535 Detail
0.028 stomach carcinoma IL-1β polymorphism and expression associated with decreased risk of gastric carc... BeFree,GAD 25773799 Detail
0.028 stomach carcinoma OPN KD gastric cancer cell lines also showed lower proliferative activity and re... BeFree,GAD 25867766 Detail
<0.001 Carcinoma of bladder NA BeFree Detail
0.002 skin carcinoma NA GAD Detail
<0.001 airway disease NA BeFree Detail
0.001 Central neuroblastoma NA BeFree Detail
<0.001 Anxiety state Variations in three cytokine genes (i.e., interleukin (IL) 1 beta, IL1 receptor ... BeFree 25249351 Detail
<0.001 Acute anterior uveitis NA BeFree Detail
<0.001 acne NA BeFree Detail
<0.001 Dissecting aneurysm of the thoracic aorta NA BeFree Detail
<0.001 Subfertility NA BeFree Detail
<0.001 Viral respiratory infection NA BeFree Detail
<0.001 diabetic macular edema NA BeFree Detail
0.002 Amyloidosis, Familial NA GAD Detail
<0.001 Middle Cerebral Artery Occlusion NA BeFree Detail
0.080 Infarction, Middle Cerebral Artery NA RGD Detail
<0.001 Febrile Neutropenia The aim of this study was to investigate the mannose-binding lectin 2 (MBL-2), i... BeFree 24819208 Detail
<0.001 early pregnancy NA BeFree Detail
<0.001 Tactile Allodynia NA BeFree Detail
<0.001 Idiopathic Inflammatory Myopathies NA BeFree Detail
<0.001 Juvenile Neuronal Ceroid Lipofuscinosis NA BeFree Detail
<0.001 Inclusion Body Myopathy, Sporadic NA BeFree Detail
0.002 Brain Hemorrhage, Traumatic NA GAD Detail
0.080 brain infarction NA RGD Detail
<0.001 Multiple Sclerosis, Relapsing-Remitting These results point to a role of the NLRP3 inflammasome and its related cytokine... BeFree 25586466 Detail
0.080 Lyme Neuroborreliosis NA RGD Detail
0.085 Hypoxia-Ischemia, Brain NA GAD,LHGDN,RGD Detail
0.001 Marden-Walker syndrome NA BeFree Detail
<0.001 Spots on skin NA BeFree Detail
0.027 Helicobacter pylori infection The data from the current study showed that the genotype IL-1B -511T/-31C-IL1-RN... BeFree,GAD 25292060 Detail
<0.001 Peritoneal infections NA BeFree Detail
<0.001 Pseudomonas aeruginosa infection NA BeFree Detail
<0.001 Endothelial dysfunction NA BeFree Detail
0.002 High altitude illness NA GAD Detail
0.001 Acute GVH disease NA BeFree Detail
<0.001 Persistant generalized lymphadenopathy NA BeFree Detail
0.200 Drug-Induced Liver Injury NA CTD_human,RGD Detail
<0.001 Chronic graft-versus-host disease NA BeFree Detail
<0.001 Hyperkeratosis NA BeFree Detail
<0.001 Infectious disease of lung NA BeFree Detail
0.121 Cardiomyopathies NA BeFree,CTD_human Detail
<0.001 Stromal Neoplasm NA BeFree Detail
0.120 Optic Atrophy, Hereditary, Leber NA CTD_human Detail
<0.001 Cerebral Ischemia NA BeFree Detail
<0.001 Arteriovenous Malformations, Cerebral NA BeFree Detail
<0.001 ovarian neoplasm NA BeFree Detail
<0.001 autoimmune thyroiditis NA BeFree Detail
<0.001 Renal ischaemia NA BeFree Detail
<0.001 Metastatic Prostate Carcinoma NA BeFree Detail
0.003 Acute coronary syndrome NA BeFree,GAD Detail
<0.001 Primary infection NOS NA BeFree Detail
<0.001 Ovarian adenocarcinoma NA BeFree Detail
<0.001 Convulsion in childhood NA BeFree Detail
0.007 coronary restenosis NA GAD Detail
<0.001 Tauopathies NA BeFree Detail
0.001 Spondylarthritis Levels of Dkk-1 were similar in SpA SF and RA SF and were not correlated with TN... BeFree 25941031 Detail
0.003 Spondylarthropathies NA BeFree,GAD Detail
0.002 Arthritis, Collagen-Induced In the present study, three bispecific and neutralizing antibodies (BsAB-1, BsAB... BeFree 24800661 Detail
0.200 Arthritis, Experimental NA CTD_human,RGD Detail
<0.001 Drug Resistant Epilepsy NA BeFree Detail
<0.001 West Nile viral infection NA BeFree Detail
<0.001 Gastric infection NA BeFree Detail
<0.001 Monoclonal Gammapathies NA BeFree Detail
<0.001 Mental Retardation, X-Linked NA BeFree Detail
0.010 Malignant neoplasm of ovary NA BeFree,GAD Detail
<0.001 Bacteremia due to Staphylococcus aureus NA BeFree Detail
<0.001 Squamous cell carcinoma of the head and neck NA BeFree Detail
0.002 severe acute respiratory syndrome NA GAD Detail
<0.001 Anemia, Diamond-Blackfan NA BeFree Detail
<0.001 sarcoma NA BeFree Detail
<0.001 Lymphocytic infiltration NA BeFree Detail
<0.001 Fungal keratitis IL-8 > IL-6 in patients with bacterial keratitis; IL-8 > IL-6 > IL-1β and increa... BeFree 25741769 Detail
0.002 major depressive disorder The IL1B genotype interacted with contextual stress such that children homozygou... BeFree 25422961 Detail
0.081 Mild cognitive disorder NA BeFree,RGD Detail
<0.001 Acral pseudolymphomatous angiokeratoma of children (APACHE) NA BeFree Detail
<0.001 Left ventricular systolic dysfunction NA BeFree Detail
<0.001 Anxiety neurosis (finding) Variations in three cytokine genes (i.e., interleukin (IL) 1 beta, IL1 receptor ... BeFree 25249351 Detail
<0.001 Degenerative disorder NA BeFree Detail
<0.001 Resorption of apex of tooth root NA BeFree Detail
0.002 Inflammatory disorder Interleukin-33 (IL-33), a new member of the IL-1 family, plays an important role... BeFree 25846650 Detail
0.002 Inflammatory disorder Interleukin-33 (IL-33) is a member of the IL-1 cytokine superfamily that potentl... BeFree 26107423 Detail
<0.001 Chronic inflammatory disorder NA BeFree Detail
<0.001 Abdominal bloating Increased IL-1β level was predominantly associated with bloating and loose stool... BeFree 25073651 Detail
0.001 Precursor B-cell lymphoblastic leukemia NA BeFree Detail
<0.001 Adenoma of large intestine NA BeFree Detail
0.002 Death (finding) NA GAD Detail
0.001 M5b Acute differentiated monocytic leukemia NA BeFree Detail
<0.001 Hepatitis B Virus-Related Hepatocellular Carcinoma NA BeFree Detail
<0.001 High Grade Cervical Intraepithelial Neoplasia NA BeFree Detail
<0.001 Intestinal Graft Versus Host Disease NA BeFree Detail
<0.001 Mucinous Neoplasm Expression of IL-1, TNF-α and COX-2 increased with the stage of the disease in b... BeFree 25007180 Detail
<0.001 Generalized osteoarthritis NA BeFree Detail
0.001 Systemic onset juvenile chronic arthritis The pro-inflammatory cytokine interleukin (IL)-1β is a clinical target in many c... BeFree 24671001 Detail
0.001 Systemic onset juvenile chronic arthritis Additionally, DNA microarray technology led to our discovery that the interleuki... BeFree 24839407 Detail
<0.001 Cardiomyopathy, Familial Idiopathic NA BeFree Detail
0.121 Mammary Neoplasms Chemokine levels were determined by ELISA in (1) human bone marrow-derived MSCs ... BeFree,CTD_human 25928089 Detail
<0.001 Hippocampal sclerosis NA BeFree Detail
0.002 Human T-cell lymphotropic virus 1 infection NA GAD Detail
<0.001 Hepatocarcinogenesis Interleukin-1β/Iinterleukin-1 receptor-associated kinase 1 inflammatory signalin... BeFree 25294684 Detail
<0.001 Hepatocarcinogenesis Cirp deficiency reduced production of interleukin-1β and interleukin-6 in Kupffe... BeFree 25611373 Detail
<0.001 Tumor Angiogenesis NA BeFree Detail
<0.001 Tumor Promotion NA BeFree Detail
<0.001 Xenograft Model NA BeFree Detail
0.017 colorectal cancer Our results, combined with previous studies, suggest that IL10, PSCA, IL1B, and ... BeFree,GAD 24557062 Detail
0.017 colorectal cancer Accordingly, IL1β and IL23 genes, typically expressed by M1 macrophages, were ex... BeFree,GAD 24737547 Detail
0.017 colorectal cancer The Th17 cell differentiation simulators IL-1β and IL-6 were also shown in an in... BeFree,GAD 24859972 Detail
0.002 brain edema NA GAD Detail
0.007 Sjogren's syndrome NA GAD,LHGDN Detail
<0.001 smoldering myeloma NA BeFree Detail
<0.001 fertility disorders NA BeFree Detail
<0.001 Pneumocystis jiroveci pneumonia NA BeFree Detail
0.080 PRESENILE AND SENILE DEMENTIA NA RGD Detail
<0.001 infective endocarditis Additionally, we detected a potential relation between interleukin-1β c.315C>T a... BeFree 25299518 Detail
<0.001 Non-Malignant Ascites Adverse Event NA BeFree Detail
<0.001 Chronic Kidney Diseases Additionally, elevated mitochondrial ROS level, colocalization of NLRP3/ASC/mito... BeFree 25798846 Detail
0.080 Renal Insufficiency NA BeFree,RGD Detail
0.002 Delayed Graft Function NA GAD Detail
<0.001 Glioblastoma multiforme NA BeFree Detail
<0.001 Cirrhosis Genetic heterogeneity in the TNFα and IL1β gene promoters influences the risk of... BeFree 24751829 Detail
<0.001 PERIODONTITIS, LOCALIZED AGGRESSIVE NA BeFree Detail
<0.001 Aggressive periodontitis, generalized NA BeFree Detail
<0.001 Severe Sepsis NA BeFree Detail
0.002 Idiopathic Pulmonary Fibrosis NA BeFree Detail
<0.001 IMMUNE SUPPRESSION NA BeFree Detail
<0.001 Recurrent bacterial infection NA BeFree Detail
<0.001 VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding) Association of neuropeptide Y (NPY), interleukin-1B (IL1B) genetic variants and ... BeFree 25221996 Detail
<0.001 Nakajo syndrome NA BeFree Detail
<0.001 severe congenital neutropenia NA BeFree Detail
<0.001 Friedreich ataxia 1 NA BeFree Detail
0.002 Venous thromboembolism NA GAD Detail
<0.001 SYNOVITIS, GRANULOMATOUS, WITH UVEITIS AND CRANIAL NEUROPATHIES (disorder) NA BeFree Detail
<0.001 Amyotrophic Lateral Sclerosis, Sporadic NA BeFree Detail
<0.001 Majeed syndrome NA BeFree Detail
<0.001 Systemic granulomatous disease NA BeFree Detail
<0.001 PHOTOPAROXYSMAL RESPONSE 1 NA BeFree Detail
<0.001 Severe Aplastic Anemia NA BeFree Detail
0.022 coronary artery disease NA BeFree,GAD Detail
<0.001 Moderate persistent asthma NA BeFree Detail
<0.001 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma NA BeFree Detail
<0.001 Precursor Cell Lymphoblastic Leukemia Lymphoma NA BeFree Detail
<0.001 Loose stool Increased IL-1β level was predominantly associated with bloating and loose stool... BeFree 25073651 Detail
<0.001 eyelids (symptom) Compared with a 1-time measurement of 8 healthy participants, among 16 symptomat... BeFree 26204109 Detail
0.030 liver carcinoma Genetic heterogeneity in the TNFα and IL1β gene promoters influences the risk of... BeFree,GAD,LHGDN 24751829 Detail
0.030 liver carcinoma In vitro studies using human hepatoma HepG2 cells showed that interleukin-1β dec... BeFree,GAD,LHGDN 25331966 Detail
0.008 Cryopyrin-Associated Periodic Syndromes The use of IL-1-antagonists has been associated with beneficial effects in a lar... BeFree 25149390 Detail
0.008 Cryopyrin-Associated Periodic Syndromes IL-1β secretion in CAPS patients correlated with disease severity. BeFree 25596455 Detail
0.008 Cryopyrin-Associated Periodic Syndromes Unexpectedly, IL-1α secretion is increased 10-fold, indicating that inflammatory... BeFree 25730877 Detail
0.008 Cryopyrin-Associated Periodic Syndromes After treatment with canakinumab (human anti-IL-1β monoclonal antibody) for CAPS... BeFree 25883259 Detail
0.008 Cryopyrin-Associated Periodic Syndromes The objective of this study was to evaluate the efficacy and safety of treatment... BeFree 26243511 Detail
<0.001 Chronic kidney disease stage 5 NA BeFree Detail
<0.001 Destructive Arthritis NA BeFree Detail
0.080 Ventilator-Induced Lung Injury NA RGD Detail
<0.001 Allergic rhinitis (disorder) NA BeFree Detail
0.080 Acute kidney injury NA RGD Detail
<0.001 Merkel Cell Polyomavirus Infection MCPyV infection can trigger precursor LCH cells with BRAF mutation to produce IL... BeFree 25889448 Detail
<0.001 Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis NA BeFree Detail
<0.001 Infectious Otitis Media This study was designed to understand the contribution of the inflammasome and I... BeFree 24652041 Detail
0.002 Weight Loss Adverse Event NA GAD Detail
0.002 Infection of amniotic sac and membranes, unspecified, unspecified trimester, not applicable or unspecified NA GAD Detail
0.005 Chronic ulcerative colitis NA GAD Detail
0.002 Recurrent pregnancy loss NA GAD Detail
<0.001 Nephropathic cystinosis NA BeFree Detail
<0.001 Juvenile dermatomyositis NA BeFree Detail
0.001 Nasopharyngeal carcinoma NA BeFree Detail
0.002 Peri-Implantitis NA BeFree Detail
<0.001 Plaque, Amyloid Interleukin-1β mediated amyloid plaque clearance is independent of CCR2 signalin... BeFree 24874542 Detail
0.002 Cerebral Hemorrhage NA GAD Detail
<0.001 Recurrent aphthous ulcer NA BeFree Detail
<0.001 limb ischemia NA BeFree Detail
<0.001 Tuberculous pleural effusion NA BeFree Detail
<0.001 Pregnancy Related Skin Change NA BeFree Detail
<0.001 Stage II Colon Cancer AJCC v7 NA BeFree Detail
<0.001 GASTRIC CANCER, INTESTINAL NA BeFree Detail
<0.001 Stroke, Lacunar NA BeFree Detail
<0.001 Nonalcoholic Steatohepatitis In the liver samples of patients with NAFLD, inflammasome components were signif... BeFree 24861026 Detail
<0.001 Severe dementia NA BeFree Detail
0.014 Juvenile arthritis NA BeFree,GAD Detail
<0.001 AA amyloidosis NA BeFree Detail
<0.001 Triple Negative Breast Neoplasms Mechanistically, cytokines such as TGFβ and IL1β could activate PKCλ/ι signaling... BeFree 24786829 Detail
<0.001 Drug Hypersensitivity Syndrome NA BeFree Detail
0.001 Neutrophilia (disorder) NA BeFree Detail
0.043 Infection NA GAD,LHGDN Detail
<0.001 Staphylococcal toxic shock syndrome NA BeFree Detail
<0.001 intellectual disability Involvement of IL-6 and IL-1 receptor antagonist on intellectual disability. BeFree 25124963 Detail
0.002 juvenile rheumatoid arthritis NA BeFree Detail
<0.001 Disorder of Achilles tendon NA BeFree Detail
0.120 Sleep Wake Disorders NA CTD_human Detail
0.122 Spontaneous abortion NA CTD_human,GAD Detail
0.002 Abortion, Habitual NA GAD Detail
0.005 Achlorhydria NA GAD,LHGDN Detail
<0.001 Acne Vulgaris NA BeFree Detail
0.003 acquired immunodeficiency syndrome NA BeFree,GAD Detail
<0.001 Acute Disease NA BeFree Detail
0.004 acute pancreatitis Influence of interleukin-1β and interleukin-6 gene polymorphisms on the developm... BeFree,GAD 25730036 Detail
0.152 adenocarcinoma NA BeFree,CTD_human,GAD,LHGDN Detail
<0.001 papillary adenocarcinoma NA BeFree Detail
<0.001 adenoma The Th17 cell differentiation simulators IL-1β and IL-6 were also shown in an in... BeFree 24859972 Detail
<0.001 Primary myelofibrosis NA BeFree Detail
0.085 AIDS Dementia Complex NA BeFree,GAD,RGD Detail
<0.001 AIDS related complex NA BeFree Detail
0.002 Albuminuria NA GAD Detail
0.006 Alcoholic Intoxication, Chronic NA BeFree,GAD Detail
0.003 alopecia areata NA BeFree,GAD Detail
0.022 Alveolar Bone Loss NA GAD,LHGDN Detail
0.080 extrinsic allergic alveolitis NA RGD Detail
0.276 Alzheimer's disease Aggravation of Alzheimer's disease due to the COX-2-mediated reciprocal regulati... BeFree,CTD_human,GAD,LHGDN,RGD 24621265 Detail
0.276 Alzheimer's disease Interleukin-1β mediated amyloid plaque clearance is independent of CCR2 signalin... BeFree,CTD_human,GAD,LHGDN,RGD 24874542 Detail
0.276 Alzheimer's disease TNF-α -308G/A and IL-8 -251T/A were significantly associated with AD and IL-1β +... BeFree,CTD_human,GAD,LHGDN,RGD 25315113 Detail
<0.001 Amputation Stumps NA BeFree Detail
0.003 amyloidosis NA BeFree,GAD Detail
<0.001 amyotrophic lateral sclerosis NA BeFree Detail
0.011 anemia NA BeFree,GAD,LHGDN Detail
<0.001 aplastic anemia NA BeFree Detail
<0.001 Anemia, Sickle Cell Interleukin-1β and interleukin-6 gene polymorphisms are associated with manifest... BeFree 25595815 Detail
<0.001 Aneurysm NA BeFree Detail
0.002 Fabry disease NA GAD Detail
<0.001 cutaneous fibrous histiocytoma NA BeFree Detail
<0.001 anhidrosis NA BeFree Detail
0.123 Anorexia NA BeFree,CTD_human,GAD Detail
0.005 Anoxia NA LHGDN Detail
0.122 anthracosis NA CTD_human,GAD Detail
<0.001 Anxiety Disorders NA BeFree Detail
<0.001 aortic aneurysm Analysis of gene expression using real-time polymerase chain reaction (PCR) reve... BeFree 24618883 Detail
0.002 Aortic Rupture NA GAD Detail
0.003 appendicitis Finally, we confirmed the involvement of the pro-inflammatory cytokines IL-1β an... BeFree,GAD 24336024 Detail
0.090 arteriosclerosis Moreover, the transcripts of interleukin 1 beta (IL-1β) and tumor necrosis facto... BeFree,GAD,RGD 25216946 Detail
0.090 arteriosclerosis These data also suggest that inhibition of this potentially important source of ... BeFree,GAD,RGD 26139463 Detail
0.090 arteriosclerosis Secretion of the cytokine interleukin-1β (IL-1β) by macrophages, a major driver ... BeFree,GAD,RGD 26185250 Detail
<0.001 Congenital arteriovenous malformation NA BeFree Detail
0.026 arthritis Redox Regulation of Pro-IL-1β Processing May Contribute to the Increased Severit... BeFree,GAD,LHGDN 25867281 Detail
0.010 Arthritis, Psoriatic NA BeFree,GAD,LHGDN Detail
0.238 rheumatoid arthritis Anakinra (IL-1 receptor antagonist) and tocilizumab (monoclonal IL-6 receptor an... BeFree,CTD_human,GAD,LHGDN 23635711 Detail
0.238 rheumatoid arthritis The pro-inflammatory cytokine interleukin (IL)-1β is a clinical target in many c... BeFree,CTD_human,GAD,LHGDN 24671001 Detail
0.238 rheumatoid arthritis Interleukin-1β (IL-1β) and interleukin-17A (IL-17A) are inducible factors and im... BeFree,CTD_human,GAD,LHGDN 24800661 Detail
0.238 rheumatoid arthritis TNFα promotes Th17 cell differentiation through IL-6 and IL-1β produced by monoc... BeFree,CTD_human,GAD,LHGDN 25436214 Detail
0.238 rheumatoid arthritis TRAF6 blockade significantly suppressed the IL‑1β‑stimulated migration and invas... BeFree,CTD_human,GAD,LHGDN 25522907 Detail
0.238 rheumatoid arthritis Antagonizing IL-1β with Anakinra, a rheumatoid arthritis therapeutic, prevented ... BeFree,CTD_human,GAD,LHGDN 25596528 Detail
0.238 rheumatoid arthritis CD44 neutralization reversed the effect of rhPRG4 on IL-1β- and TNFα-stimulated ... BeFree,CTD_human,GAD,LHGDN 25708025 Detail
0.238 rheumatoid arthritis Here, we found that the levels of IL-1β and Cyr61 were higher in RA SF than in o... BeFree,CTD_human,GAD,LHGDN 25728492 Detail
0.238 rheumatoid arthritis Levels of Dkk-1 were similar in SpA SF and RA SF and were not correlated with TN... BeFree,CTD_human,GAD,LHGDN 25941031 Detail
<0.001 asbestosis NA BeFree Detail
0.002 aspergillosis NA GAD Detail
0.002 asphyxia neonatorum NA GAD Detail
0.153 asthma IL-33 is a nuclear cytokine from the IL-1 family constitutively expressed in epi... BeFree,CTD_human,GAD,LHGDN 25278425 Detail
0.153 asthma Airway IL-1β and Systemic Inflammation as Predictors of Future Exacerbation Risk... BeFree,CTD_human,GAD,LHGDN 25950204 Detail
0.004 Astrocytoma NA BeFree Detail
0.022 atherosclerosis Moreover, the transcripts of interleukin 1 beta (IL-1β) and tumor necrosis facto... BeFree,GAD,LHGDN 25216946 Detail
0.022 atherosclerosis These data also suggest that inhibition of this potentially important source of ... BeFree,GAD,LHGDN 26139463 Detail
0.022 atherosclerosis Secretion of the cytokine interleukin-1β (IL-1β) by macrophages, a major driver ... BeFree,GAD,LHGDN 26185250 Detail
0.002 atrial fibrillation NA GAD Detail
<0.001 Tooth Attrition NA BeFree Detail
0.010 Autoimmune Diseases Type 1 Diabetes (T1D) is an autoimmune disease where local release of cytokines ... BeFree,GAD 24462878 Detail
0.010 Autoimmune Diseases Interleukin-1β promotes the induction of retinal autoimmune disease. BeFree,GAD 25017970 Detail
0.010 Autoimmune Diseases IL-37, a new member of the IL-1 cytokine family, is a natural inhibitor of innat... BeFree,GAD 25917106 Detail
0.005 azoospermia NA GAD Detail
<0.001 Melanoma, B16 Cytokines, that is, interleukin-1β and tumor necrosis factor-α from MDSCs are re... BeFree 24882582 Detail
<0.001 Bacteremia NA BeFree Detail
0.002 Bacterial Infections NA BeFree Detail
<0.001 Balkan nephropathy NA BeFree Detail
<0.001 Mental disorders NA BeFree Detail
0.011 Behcet Syndrome NA BeFree,GAD,LHGDN Detail
0.002 berylliosis NA GAD Detail
0.002 Biliary Tract Neoplasm NA GAD Detail
0.006 bipolar disorder NA BeFree,GAD,LHGDN Detail
0.013 Malignant neoplasm of urinary bladder NA BeFree,GAD Detail
<0.001 Blast Phase NA BeFree Detail
0.003 Blood Coagulation Disorders NA BeFree,GAD Detail
0.003 Bone Diseases NA BeFree,GAD Detail
0.002 Metabolic Bone Disorder NA GAD Detail
<0.001 borderline personality disorder NA BeFree Detail
0.002 Brain Damage, Chronic NA GAD Detail
<0.001 Brain Neoplasms NA BeFree Detail
0.034 Malignant neoplasm of breast Here, we identified the impact of TNF-α and IL-1β on the inflammatory phenotype ... BeFree,GAD 25928089 Detail
0.002 Bronchiolitis, Viral NA GAD Detail
0.123 bronchopulmonary dysplasia NA BeFree,CTD_human,LHGDN Detail
0.002 burning mouth syndrome NA GAD Detail
0.089 Cachexia NA BeFree,GAD,LHGDN,RGD Detail
0.120 calcinosis NA CTD_human Detail
0.002 Campylobacter infection NA GAD Detail
0.003 candidiasis NA BeFree,GAD Detail
0.002 Malignant tumor of colon NA BeFree Detail
<0.001 Malignant neoplasm of larynx NA BeFree Detail
0.002 basal cell carcinoma NA GAD Detail
0.002 Non-small cell lung carcinoma Together, our findings defined an IL-1β-miR-101-Lin28B pathway as a novel regula... BeFree 24958470 Detail
0.001 renal cell carcinoma Supporting this, meta-analysis of gene expression from human RCC tumors showed I... BeFree 25453823 Detail
Annotation

Annotations

DescrptionSourceLinks
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In the Chinese subgroup, nominally significant associations were shown between (i) EBBR2+1963G (rs18... DisGeNET Detail
In the Chinese subgroup, nominally significant associations were shown between (i) EBBR2+1963G (rs18... DisGeNET Detail
In the Chinese subgroup, nominally significant associations were shown between (i) EBBR2+1963G (rs18... DisGeNET Detail
Genome-wide gene expression profiling by MACE (Massive Analysis of cDNA Ends) identified 80 genes to... DisGeNET Detail
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Interleukin 1β and interleukin 1 receptor antagonist gene polymorphisms and cervical cancer: a meta-... DisGeNET Detail
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This study suggested that persistent expression of extracellular HMGB-1 and DNA fragments in cholest... DisGeNET Detail
Interleukin-1β induced nuclear factor-κB binds to a disintegrin-like and metalloproteinase with thro... DisGeNET Detail
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Our results, combined with previous studies, suggest that IL10, PSCA, IL1B, and SMAD7 are significan... DisGeNET Detail
Accordingly, IL1β and IL23 genes, typically expressed by M1 macrophages, were expressed to significa... DisGeNET Detail
The Th17 cell differentiation simulators IL-1β and IL-6 were also shown in an increase trend from th... DisGeNET Detail
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As Th17 cytokines, such as IL-17A, and IL-1 family members, such as IL-36, play a significant role i... DisGeNET Detail
IL-1β -511 CC genotype was significantly less present in UC compared to controls, while IL-1RA Mspa-... DisGeNET Detail
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Pro-inflammatory alleles of three cytokine genotypes, IL-8, IL-10 and IL-1β, appear to be associated... DisGeNET Detail
Here we demonstrate that the degree and quality of the inflammatory response in CF are supported by ... DisGeNET Detail
Antagonizing IL-1β with Anakinra, a rheumatoid arthritis therapeutic, prevented detrusor proliferati... DisGeNET Detail
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Spleen Tyrosine Kinase (Syk) Mediates IL-1β Induction by Primary Human Monocytes during Antibody-enh... DisGeNET Detail
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TNF-α -308G/A and IL-8 -251T/A were significantly associated with AD and IL-1β +3953C/T with late-li... DisGeNET Detail
TNF-α -308G/A and IL-8 -251T/A were significantly associated with AD and IL-1β +3953C/T with late-li... DisGeNET Detail
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Caspase-1-dependent IL-1β secretion was impaired in monocytes from patients with AD compared to pati... DisGeNET Detail
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Interleukin-1β (IL-1β) is one of the key proinflammatory cytokines that contributes to the generatio... DisGeNET Detail
Interleukin-1β (IL-1β) is one of the key proinflammatory cytokines that contributes to the generatio... DisGeNET Detail
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Type 1 Diabetes (T1D) is an autoimmune disease where local release of cytokines such as IL-1β and IF... DisGeNET Detail
Our results support the hypothesis that T2D pathology contributes in vivo to increase the inflammato... DisGeNET Detail
Non-alcoholic fatty liver disease is prevalent in human obesity and type 2 diabetes, and is characte... DisGeNET Detail
The expression of GPR109A, NF-kB and IL-1β in peripheral blood leukocytes from patients with type 2 ... DisGeNET Detail
These data provide the first in vivo evidence—using a transgenic mouse model with amyloid deposits r... DisGeNET Detail
Our studies identify a regulatory mechanism controlling diet-induced insulin resistance by highlight... DisGeNET Detail
In this work, an increased production of IL-1β by MO obtained from patients affected by both RA and ... DisGeNET Detail
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Increased IL-1β level was predominantly associated with bloating and loose stools (Bristol type 6). DisGeNET Detail
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All genes increased in response to initial stress (IL-6: F=3.8; p=0.029; IL-1β: F=7.1; p=0.008; NF-κ... DisGeNET Detail
Hence in this study we determine whether: a) ROS activated NLRP3 inflammasomes mediate hyperosmotic ... DisGeNET Detail
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The mechanisms may include the following pathways: [TGFB1 or TNFA]-[IL1B]-[pre-eclampsia]; [TNFA or ... DisGeNET Detail
Caspase-1-dependent IL-1β secretion was impaired in monocytes from patients with AD compared to pati... DisGeNET Detail
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Additionally, we detected a potential relation between interleukin-1β c.315C>T and IE. DisGeNET Detail
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Genomic analysis of the interleukin-1β-511 and interleukin-6-174 gene polymorphisms in Turkish patie... DisGeNET Detail
Interleukin-1β plays a role in the pathogenesis of mesial temporal lobe epilepsy through the PI3K/Ak... DisGeNET Detail
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The data from the current study showed that the genotype IL-1B -511T/-31C-IL1-RN-2 and H. pylori inf... DisGeNET Detail
HP-infected OPN KO mice showed significantly reduced gastritis compared with wild-type (WT) mice wit... DisGeNET Detail
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IL-1β genetic polymorphisms may take part in the pathophysiology of gastroesophageal reflux disease. DisGeNET Detail
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The secretion of IL-1β from glioblastoma cells in turn stimulates the expression of COX-2 in human o... DisGeNET Detail
Specifically, the ability to produce IL-1 by glioblastoma cells may confer them a mesenchymal phenot... DisGeNET Detail
Taken together, p38 MAPK-MK2-HuR signalling may enhance the potential of intrinsic (EGFRvIII) and ex... DisGeNET Detail
IL-1 also activated Stat3, a transcription factor crucial in glioma progression. DisGeNET Detail
The effect of hBMVEC on C6 glioma sCp expression at the level of transcript and protein was represse... DisGeNET Detail
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At baseline, GVL was independently associated with IL-1β after controlling for PVL, age and N. gonor... DisGeNET Detail
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These data indicate that IL-1β and IL-6 gene SNPs are associated with SCA complications among Brazil... DisGeNET Detail
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IL-1β is a potent inflammatory cytokine that is frequently elevated during severe dengue, and the un... DisGeNET Detail
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MCPyV infection can trigger precursor LCH cells with BRAF mutation to produce IL-1; the IL-1 loop is... DisGeNET Detail
During acute HIV infection, circulating Gal-9 was detected as early as 5 days after quantifiable HIV... DisGeNET Detail
In HIV-infected men, semen bacterial load correlated with seven pro-inflammatory semen cytokines, in... DisGeNET Detail
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IL-1β is produced mainly by monocytes (MO), and hyperglycaemia may be able to modulate, in the cytop... DisGeNET Detail
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In addition, the cytokines IL-1β, IL-6 and IFN-γ may be potential targets for treating patients with... DisGeNET Detail
IL-1 SNPs seem to be associated with IBD and could affect the disease severity as well. DisGeNET Detail
In 55 subjects with paired exacerbation data, qPCR bacterial load fold change at exacerbation in M c... DisGeNET Detail
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Expression of IL-8, IL-6 and IL-1β in tears as a main characteristic of the immune response in human... DisGeNET Detail
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IL-1β +3954C>T SNP was associated with increased risk of osteonecrosis, elevated pulmonary arterial ... DisGeNET Detail
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Moreover, our data supports the genetic influence of IL1β, IL12RB1 and CISH genes and the susceptibi... DisGeNET Detail
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Genetic heterogeneity in the TNFα and IL1β gene promoters influences the risk of HCC in patients wit... DisGeNET Detail
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In vitro studies using human hepatoma HepG2 cells showed that interleukin-1β decreased the mRNA leve... DisGeNET Detail
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Pro-inflammatory alleles of three cytokine genotypes, IL-8, IL-10 and IL-1β, appear to be associated... DisGeNET Detail
The high-IL-1β expressing genotype was associated with the development of active tuberculosis, the s... DisGeNET Detail
Moreover, recent studies suggested that IL-1 participates in the progression of lung disease in smok... DisGeNET Detail
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Association between the IL1B, IL1RN polymorphisms and COPD risk: a meta-analysis. DisGeNET Detail
Association of interleukin-1β -511C/T promoter polymorphism with COPD risk: a meta-analysis. DisGeNET Detail
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Included in this rubric is the concept that activation of the inflammasome, a molecular complex that... DisGeNET Detail
Included in this rubric is the concept that activation of the inflammasome, a molecular complex that... DisGeNET Detail
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Included in this rubric is the concept that activation of the inflammasome, a molecular complex that... DisGeNET Detail
Furthermore, a significant negative association was found between the T/C genotype at the same posit... DisGeNET Detail
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The course of gastric cancer following surgery is associated with genetic variations of the interleu... DisGeNET Detail
The allele flip observed in IL-10 and gastric cancer appears to reflect allelic heterogeneity, simil... DisGeNET Detail
Wnt5a was overexpressed in gastric cancer tissues, and correlated with monocyte chemotactic protein ... DisGeNET Detail
Interactions between pork consumption, CagA status and IL-1B-31 genotypes in gastric cancer. DisGeNET Detail
IL-1B-31 locus polymorphism may be associated with gastric cancer susceptibility in this population,... DisGeNET Detail
IL-1B (C+3954T) gene polymorphism and susceptibility to gastric cancer in the Iranian population. DisGeNET Detail
OPN KD gastric cancer cell lines also showed lower proliferative activity and reduced MAPK activatio... DisGeNET Detail
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IL-1β-secreting nucleotide-binding oligomerization domain protein 3 (NLRP3) inflammasomes play a piv... DisGeNET Detail
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The analysis of correlation between IL-1B gene expression and genotyping in multiple sclerosis patie... DisGeNET Detail
The serum levels of numerous cytokines (IL-1β, IL-12, IL-6, TNF-α, IFN-γ, IL-4, IL-10, and IL-17) se... DisGeNET Detail
One mechanism by which IL-1β might be involved in MS is by inducing pathogenic Th17 cells, i.e.GM-CS... DisGeNET Detail
To replicate and extend recent findings in a Turkish population of associations between chronic rhin... DisGeNET Detail
To replicate and extend recent findings in a Turkish population of associations between chronic rhin... DisGeNET Detail
To replicate and extend recent findings in a Turkish population of associations between chronic rhin... DisGeNET Detail
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In contrast to the role of IL-1α in neutrophil recruitment, the inflammasome and IL-1β were only ess... DisGeNET Detail
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Among the female patients presenting metastatic disease and carriers of the TT genotype we observed ... DisGeNET Detail
These results suggest that tested SNPs associated with differential production of IL-1 female and IL... DisGeNET Detail
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The results of the current study demonstrated that pro-inflammatory cytokines, including TGF-β1, IL-... DisGeNET Detail
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We used human adipose tissue biopsies to study the relationship of MAP3K8 expression with markers of... DisGeNET Detail
Cytokines of the IL-1 family are important modulators of obesity-induced inflammation and the develo... DisGeNET Detail
Furthermore, the administration of IL-1 receptor antagonist to obese mice markedly reduced obesity-i... DisGeNET Detail
Interleukin-1β (IL-1β) is one of the key proinflammatory cytokines that contributes to the generatio... DisGeNET Detail
Monounsaturated fatty acid-enriched high-fat diets impede adipose NLRP3 inflammasome-mediated IL-1β ... DisGeNET Detail
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Rabbit cartilage was treated with various concentrations of DHEA in both IL-1β-induced rabbit chondr... DisGeNET Detail
Moreover, the OA-related catabolic factor interleukin-1β induced the expression of Apex 2 in chondro... DisGeNET Detail
MiR-602 and miR-608 are important posttranscription regulators of SHH expression in OA chondrocytes,... DisGeNET Detail
In addition, the data also shows that overexpression of HDAC4 not only decreased the expression of i... DisGeNET Detail
Astragalin inhibits IL-1β-induced inflammatory mediators production in human osteoarthritis chondroc... DisGeNET Detail
Here, we found that the levels of IL-1β and Cyr61 were higher in RA SF than in osteoarthritis (OA) S... DisGeNET Detail
Gene and protein expression in IL-1β-stimulated human OA chondrocytes/cartilage was determined by Ta... DisGeNET Detail
Effect of Bushenhuoxue formula on interleukin-1 beta and discoidin domain receptor 2 levels in a rat... DisGeNET Detail
Berberine attenuates CCN2-induced IL-1β expression and prevents cartilage degradation in a rat model... DisGeNET Detail
Expression of miR-139 was found to be high in the damaged portion of the OA cartilage compared with ... DisGeNET Detail
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Genetic polymorphisms of interleukin-1 beta and osteosarcoma risk. DisGeNET Detail
This study was designed to understand the contribution of the inflammasome and IL-1β activation in o... DisGeNET Detail
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Administration of MSCs alone significantly reduced pancreatic injury and inflammation, as reflected ... DisGeNET Detail
Pro and anti-inflammatory cytokines did not show significant differences between the groups; however... DisGeNET Detail
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The absence of spontaneous IL-1β release by PBMCs reflects no constitutive activation of the inflamm... DisGeNET Detail
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A meta-analysis of the three populations supported the association between the IL-1 genotype pattern... DisGeNET Detail
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TNB instillations in IL-1R null mice demonstrated the critical role of IL-1β in initiation of TNB-in... DisGeNET Detail
The studies involved the following polymorphisms: TNF-α -308G > A, TNF-α -805C>T, TNF-α -1031 T>C, I... DisGeNET Detail
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Our results indicate that one of the early steps of psoriasis pathogenesis may be the abnormal regul... DisGeNET Detail
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The protective effects of bLF against hyperoxia were further confirmed by significant reductions in ... DisGeNET Detail
In vitro studies revealed that Thal decreased 1) the expression of IL-1β and IL-6 in human lung epit... DisGeNET Detail
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Our work demonstrates that in the context of an established animal model for ocular disease, the per... DisGeNET Detail
IL-1β +3954C>T SNP was associated with increased risk of osteonecrosis, elevated pulmonary arterial ... DisGeNET Detail
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Here, we demonstrate that neutrophils, typically viewed as cellular targets of IL-1β, themselves act... DisGeNET Detail
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Moreover, recent studies suggested that IL-1 participates in the progression of lung disease in smok... DisGeNET Detail
Immunohistochemical analysis showed stronger staining of NLRP3 and IL-1β cytoplasmic expression in t... DisGeNET Detail
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These data are the first to demonstrate that the inflammatory response induced by IL-1β promotes sei... DisGeNET Detail
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IL-33 is a novel IL-1 family member with a putative role in inflammatory skin disorders and a comple... DisGeNET Detail
As Th17 cytokines, such as IL-17A, and IL-1 family members, such as IL-36, play a significant role i... DisGeNET Detail
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The association between three promoter polymorphisms of IL-1 and stroke: a meta-analysis. DisGeNET Detail
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We conclude that caspase-1/ASC inflammasomes play a significant role in the activation of IL-1β/ROS ... DisGeNET Detail
Allele-specific induction of IL-1β expression by C/EBPβ and PU.1 contributes to increased tuberculos... DisGeNET Detail
Most of the host components involved in TB inflammation, including cytokines (interferons, interleuk... DisGeNET Detail
Among our most significant findings were SNPs in TICAM2 (P = 3.6 × 10(-6)) and IL1B (P = 4.3 × 10(-5... DisGeNET Detail
IL-1β+3953C/T, -511T/C and IL-6 -174C/G polymorphisms in association with tuberculosis susceptibilit... DisGeNET Detail
1,25(OH)2D3 significantly suppressed all the CFA induced pro-inflammatory cytokines (p<0.05) studied... DisGeNET Detail
In this study we aimed to examine the possible association between the variable number of tandem rep... DisGeNET Detail
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The IL1B genotype interacted with contextual stress such that children homozygous for the minor alle... DisGeNET Detail
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These results suggest that IL-1β is an important mediator in the pathogenesis of autoimmune diseases... DisGeNET Detail
New cytokine inhibitors targeting IL-1 and IL-6 appear to be effective especially for uveitis and CN... DisGeNET Detail
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This could reveal additional potential anti-IL-1β therapeutic targets and provide further insights i... DisGeNET Detail
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Association of neuropeptide Y (NPY), interleukin-1B (IL1B) genetic variants and correlation of IL1B ... DisGeNET Detail
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The levels of interleukin-1α (IL-1α), IL-1β, IL-6, IL-12(p70), and IL-8 were elevated, whereas the I... DisGeNET Detail
Thus, the aims of this study were (i) to determine whether GSK3 is increased in adipose tissue and s... DisGeNET Detail
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Our previous study showed that PGA activates the human macrophage cell line THP-1 and human dendriti... DisGeNET Detail
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IL-1 may be involved in clinical manifestation of certain (genetic) forms of PG. DisGeNET Detail
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The aim of this study was to investigate the mannose-binding lectin 2 (MBL-2), interleukin (IL)-4, T... DisGeNET Detail
Finally, we confirmed the involvement of the pro-inflammatory cytokines IL-1β and IL-8, and detected... DisGeNET Detail
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The levels of inflammatory cytokines IL-6, IL-8, IL-1β and TNF-α in the HNE2 cell group after EBV in... DisGeNET Detail
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The high-IL-1β expressing genotype was associated with the development of active tuberculosis, the s... DisGeNET Detail
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Coronary arteries from patients with ischemic heart disease express large amounts of IL-1β in the en... DisGeNET Detail
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Whereas IL-1β promotes Th1 and Th17 responses and gastric immunopathology, IL-18 is required for Tre... DisGeNET Detail
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We investigated whether expression of xylosyltransferase-1 (XT-1), a key enzyme in glycosaminoglycan... DisGeNET Detail
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The role of AIM2 in affecting pro-inflammatory activation of Kupffer cells by inducing IL-1β product... DisGeNET Detail
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In patients with a pyoderma gangrenosum, acne, and suppurative hidradenitis syndrome these mutations... DisGeNET Detail
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Mounting evidence supports that chronic inflammation (such as chronic overactivation of IL-1 system)... DisGeNET Detail
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Moreover, the T-allele of IL-1β showed increased susceptibility for CIN [OR = 3.62(0.85-17.95), p = ... DisGeNET Detail
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We showed that SIRT1 is reduced with the aging of microglia and that microglial SIRT1 deficiency has... DisGeNET Detail
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The consequence of VILI by H&E stain showed inducing lung congestion and increasing the expression o... DisGeNET Detail
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This study validated the influence of IL-1 genetic factors on the severity of chronic periodontitis ... DisGeNET Detail
In conclusion, the present study suggests a strong association of the TT genotype of -511 and CT gen... DisGeNET Detail
In the study population examined, the SNP in the IL1B gene (+3954) and VNTR polymorphisms in the IL1... DisGeNET Detail
Genetic polymorphisms of CYP2C19 and IL1B have no influence on esomeprazole treatment for mild erosi... DisGeNET Detail
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Compared with the ANP group, the mRNA and protein expression of IREl a and the protein expression of... DisGeNET Detail
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A2M and its interactive proteins, such as IL1B, LRP1 and PDGF may be candidate target molecules to m... DisGeNET Detail
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Hence in this study we determine whether: a) ROS activated NLRP3 inflammasomes mediate hyperosmotic ... DisGeNET Detail
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Interleukin-1β mediated amyloid plaque clearance is independent of CCR2 signaling in the APP/PS1 mou... DisGeNET Detail
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SIRT1 deficiency in microglia contributes to cognitive decline in aging and neurodegeneration via ep... DisGeNET Detail
Interleukin-1 beta/IL-1B/(2.3-fold) and interleukin-6/IL-6/(2.4-fold) were upregulated both with mic... DisGeNET Detail
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We found that interleukin (IL) 6 (IL-6), IL-1β, monocyte chemoattractant protein-1 (CCL2) macrophage... DisGeNET Detail
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OPN KD gastric cancer cell lines also showed lower proliferative activity and reduced MAPK activatio... DisGeNET Detail
Genotypes of IL-1β (-511,-31), IL-1RN gene polymorphisms and HP status of the patients were analyzed... DisGeNET Detail
Inflammasome activation and caspase-1-dependent (CASP1-dependent) processing and secretion of IL-1β ... DisGeNET Detail
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Both IL-1β and IFNβ may be new biomarkers to distinguish high-risk/low-risk patients with prostate c... DisGeNET Detail
IL-1β induces p62/SQSTM1 and represses androgen receptor expression in prostate cancer cells. DisGeNET Detail
Genetic polymorphism of interleukin-1A (IL-1A), IL-1B, and IL-1 receptor antagonist (IL-1RN) and pro... DisGeNET Detail
Investigation of Interleukin-1β Polymorphisms in Prostate Cancer. DisGeNET Detail
Association of IL-1β and IL-10 Polymorphisms with Prostate Cancer Risk and Grade of Disease in Easte... DisGeNET Detail
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In the liver samples of patients with NAFLD, inflammasome components were significantly increased in... DisGeNET Detail
Non-alcoholic fatty liver disease is prevalent in human obesity and type 2 diabetes, and is characte... DisGeNET Detail
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As Th17 cytokines, such as IL-17A, and IL-1 family members, such as IL-36, play a significant role i... DisGeNET Detail
However, epiphyseal overgrowth in NOMID is resistant to anti-IL-1 therapy and may therefore occur in... DisGeNET Detail
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Included in this rubric is the concept that activation of the inflammasome, a molecular complex that... DisGeNET Detail
Deregulation of the IL-1β axis in chronic recurrent multifocal osteomyelitis. DisGeNET Detail
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Thus, circadian rhythms, nest construction, IL-1β and TNF-α, and glial fibrillary acidic protein (GF... DisGeNET Detail
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Aberrant expression of interleukin-1β and inflammasome activation in human malignant gliomas. DisGeNET Detail
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Genetic polymorphisms of interleukin-1 beta and osteosarcoma risk. DisGeNET Detail
Also in line with hypotheses, the -511C allele in IL1β, previously associated with higher IL-1β expr... DisGeNET Detail
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Emerging evidence has demonstrated that polymorphisms of interleukin-1 (IL-1) may be involved in hum... DisGeNET Detail
Interleukin-1 beta (IL-1B) is crucially involved in osteosarcoma carcinogenesis. DisGeNET Detail
IL-1β-mediated repression of microRNA-101 is crucial for inflammation-promoted lung tumorigenesis. DisGeNET Detail
Mounting evidence supports that chronic inflammation (such as chronic overactivation of IL-1 system)... DisGeNET Detail
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Both IL-1β and IFNβ may be new biomarkers to distinguish high-risk/low-risk patients with prostate c... DisGeNET Detail
IL-1β induces p62/SQSTM1 and represses androgen receptor expression in prostate cancer cells. DisGeNET Detail
Genetic polymorphism of interleukin-1A (IL-1A), IL-1B, and IL-1 receptor antagonist (IL-1RN) and pro... DisGeNET Detail
Investigation of Interleukin-1β Polymorphisms in Prostate Cancer. DisGeNET Detail
Association of IL-1β and IL-10 Polymorphisms with Prostate Cancer Risk and Grade of Disease in Easte... DisGeNET Detail
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Interleukin 1 beta (IL1beta) gene polymorphisms (SNP-511 and SNP+3953) in Hashimoto's thyroiditis am... DisGeNET Detail
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Here, we identified the impact of TNF-α and IL-1β on the inflammatory phenotype of CAFs and MSCs by ... DisGeNET Detail
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New cytokine inhibitors targeting IL-1 and IL-6 appear to be effective especially for uveitis and CN... DisGeNET Detail
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The course of gastric cancer following surgery is associated with genetic variations of the interleu... DisGeNET Detail
The allele flip observed in IL-10 and gastric cancer appears to reflect allelic heterogeneity, simil... DisGeNET Detail
Wnt5a was overexpressed in gastric cancer tissues, and correlated with monocyte chemotactic protein ... DisGeNET Detail
Interactions between pork consumption, CagA status and IL-1B-31 genotypes in gastric cancer. DisGeNET Detail
IL-1B-31 locus polymorphism may be associated with gastric cancer susceptibility in this population,... DisGeNET Detail
IL-1B (C+3954T) gene polymorphism and susceptibility to gastric cancer in the Iranian population. DisGeNET Detail
IL-1β polymorphism and expression associated with decreased risk of gastric carcinoma: a case contro... DisGeNET Detail
OPN KD gastric cancer cell lines also showed lower proliferative activity and reduced MAPK activatio... DisGeNET Detail
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Variations in three cytokine genes (i.e., interleukin (IL) 1 beta, IL1 receptor 2 (IL1R2), nuclear f... DisGeNET Detail
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The aim of this study was to investigate the mannose-binding lectin 2 (MBL-2), interleukin (IL)-4, T... DisGeNET Detail
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These results point to a role of the NLRP3 inflammasome and its related cytokine IL1B in the respons... DisGeNET Detail
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The data from the current study showed that the genotype IL-1B -511T/-31C-IL1-RN-2 and H. pylori inf... DisGeNET Detail
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Levels of Dkk-1 were similar in SpA SF and RA SF and were not correlated with TNF and IL-1β levels. DisGeNET Detail
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In the present study, three bispecific and neutralizing antibodies (BsAB-1, BsAB-2 and BsAB-3) again... DisGeNET Detail
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IL-8 > IL-6 in patients with bacterial keratitis; IL-8 > IL-6 > IL-1β and increased frequency of cir... DisGeNET Detail
The IL1B genotype interacted with contextual stress such that children homozygous for the minor alle... DisGeNET Detail
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Variations in three cytokine genes (i.e., interleukin (IL) 1 beta, IL1 receptor 2 (IL1R2), nuclear f... DisGeNET Detail
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Interleukin-33 (IL-33), a new member of the IL-1 family, plays an important role in both inflammator... DisGeNET Detail
Interleukin-33 (IL-33) is a member of the IL-1 cytokine superfamily that potently drives production ... DisGeNET Detail
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Increased IL-1β level was predominantly associated with bloating and loose stools (Bristol type 6). DisGeNET Detail
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Expression of IL-1, TNF-α and COX-2 increased with the stage of the disease in both serous and mucin... DisGeNET Detail
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The pro-inflammatory cytokine interleukin (IL)-1β is a clinical target in many conditions involving ... DisGeNET Detail
Additionally, DNA microarray technology led to our discovery that the interleukin (IL)-1 gene signat... DisGeNET Detail
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Chemokine levels were determined by ELISA in (1) human bone marrow-derived MSCs stimulated by tumor ... DisGeNET Detail
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Interleukin-1β/Iinterleukin-1 receptor-associated kinase 1 inflammatory signaling contributes to per... DisGeNET Detail
Cirp deficiency reduced production of interleukin-1β and interleukin-6 in Kupffer cells, ROS accumul... DisGeNET Detail
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Our results, combined with previous studies, suggest that IL10, PSCA, IL1B, and SMAD7 are significan... DisGeNET Detail
Accordingly, IL1β and IL23 genes, typically expressed by M1 macrophages, were expressed to significa... DisGeNET Detail
The Th17 cell differentiation simulators IL-1β and IL-6 were also shown in an increase trend from th... DisGeNET Detail
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Additionally, we detected a potential relation between interleukin-1β c.315C>T and IE. DisGeNET Detail
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Additionally, elevated mitochondrial ROS level, colocalization of NLRP3/ASC/mitochondria in peripher... DisGeNET Detail
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Genetic heterogeneity in the TNFα and IL1β gene promoters influences the risk of HCC in patients wit... DisGeNET Detail
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Association of neuropeptide Y (NPY), interleukin-1B (IL1B) genetic variants and correlation of IL1B ... DisGeNET Detail
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Increased IL-1β level was predominantly associated with bloating and loose stools (Bristol type 6). DisGeNET Detail
Compared with a 1-time measurement of 8 healthy participants, among 16 symptomatic patients, the mea... DisGeNET Detail
Genetic heterogeneity in the TNFα and IL1β gene promoters influences the risk of HCC in patients wit... DisGeNET Detail
In vitro studies using human hepatoma HepG2 cells showed that interleukin-1β decreased the mRNA leve... DisGeNET Detail
The use of IL-1-antagonists has been associated with beneficial effects in a large number of HAID as... DisGeNET Detail
IL-1β secretion in CAPS patients correlated with disease severity. DisGeNET Detail
Unexpectedly, IL-1α secretion is increased 10-fold, indicating that inflammatory episodes in CAPS ma... DisGeNET Detail
After treatment with canakinumab (human anti-IL-1β monoclonal antibody) for CAPS, the inflammatory r... DisGeNET Detail
The objective of this study was to evaluate the efficacy and safety of treatment with the long-lasti... DisGeNET Detail
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MCPyV infection can trigger precursor LCH cells with BRAF mutation to produce IL-1; the IL-1 loop is... DisGeNET Detail
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This study was designed to understand the contribution of the inflammasome and IL-1β activation in o... DisGeNET Detail
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Interleukin-1β mediated amyloid plaque clearance is independent of CCR2 signaling in the APP/PS1 mou... DisGeNET Detail
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In the liver samples of patients with NAFLD, inflammasome components were significantly increased in... DisGeNET Detail
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Mechanistically, cytokines such as TGFβ and IL1β could activate PKCλ/ι signaling in TNBC cells and d... DisGeNET Detail
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Involvement of IL-6 and IL-1 receptor antagonist on intellectual disability. DisGeNET Detail
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Influence of interleukin-1β and interleukin-6 gene polymorphisms on the development of acute pancrea... DisGeNET Detail
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The Th17 cell differentiation simulators IL-1β and IL-6 were also shown in an increase trend from th... DisGeNET Detail
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Aggravation of Alzheimer's disease due to the COX-2-mediated reciprocal regulation of IL-1β and Aβ b... DisGeNET Detail
Interleukin-1β mediated amyloid plaque clearance is independent of CCR2 signaling in the APP/PS1 mou... DisGeNET Detail
TNF-α -308G/A and IL-8 -251T/A were significantly associated with AD and IL-1β +3953C/T with late-li... DisGeNET Detail
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Interleukin-1β and interleukin-6 gene polymorphisms are associated with manifestations of sickle cel... DisGeNET Detail
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Analysis of gene expression using real-time polymerase chain reaction (PCR) revealed significantly i... DisGeNET Detail
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Finally, we confirmed the involvement of the pro-inflammatory cytokines IL-1β and IL-8, and detected... DisGeNET Detail
Moreover, the transcripts of interleukin 1 beta (IL-1β) and tumor necrosis factor α (TNFα), which ar... DisGeNET Detail
These data also suggest that inhibition of this potentially important source of chronic inflammation... DisGeNET Detail
Secretion of the cytokine interleukin-1β (IL-1β) by macrophages, a major driver of pathogenesis in a... DisGeNET Detail
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Redox Regulation of Pro-IL-1β Processing May Contribute to the Increased Severity of Serum-Induced A... DisGeNET Detail
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Anakinra (IL-1 receptor antagonist) and tocilizumab (monoclonal IL-6 receptor antibody) are two know... DisGeNET Detail
The pro-inflammatory cytokine interleukin (IL)-1β is a clinical target in many conditions involving ... DisGeNET Detail
Interleukin-1β (IL-1β) and interleukin-17A (IL-17A) are inducible factors and important cytokines in... DisGeNET Detail
TNFα promotes Th17 cell differentiation through IL-6 and IL-1β produced by monocytes in rheumatoid a... DisGeNET Detail
TRAF6 blockade significantly suppressed the IL‑1β‑stimulated migration and invasion of human RA‑FLSs... DisGeNET Detail
Antagonizing IL-1β with Anakinra, a rheumatoid arthritis therapeutic, prevented detrusor proliferati... DisGeNET Detail
CD44 neutralization reversed the effect of rhPRG4 on IL-1β- and TNFα-stimulated RA FLS and the effec... DisGeNET Detail
Here, we found that the levels of IL-1β and Cyr61 were higher in RA SF than in osteoarthritis (OA) S... DisGeNET Detail
Levels of Dkk-1 were similar in SpA SF and RA SF and were not correlated with TNF and IL-1β levels. DisGeNET Detail
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IL-33 is a nuclear cytokine from the IL-1 family constitutively expressed in epithelial barrier tiss... DisGeNET Detail
Airway IL-1β and Systemic Inflammation as Predictors of Future Exacerbation Risk in Asthma and COPD. DisGeNET Detail
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Moreover, the transcripts of interleukin 1 beta (IL-1β) and tumor necrosis factor α (TNFα), which ar... DisGeNET Detail
These data also suggest that inhibition of this potentially important source of chronic inflammation... DisGeNET Detail
Secretion of the cytokine interleukin-1β (IL-1β) by macrophages, a major driver of pathogenesis in a... DisGeNET Detail
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Type 1 Diabetes (T1D) is an autoimmune disease where local release of cytokines such as IL-1β and IF... DisGeNET Detail
Interleukin-1β promotes the induction of retinal autoimmune disease. DisGeNET Detail
IL-37, a new member of the IL-1 cytokine family, is a natural inhibitor of innate immunity associate... DisGeNET Detail
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Cytokines, that is, interleukin-1β and tumor necrosis factor-α from MDSCs are required for B16 melan... DisGeNET Detail
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Here, we identified the impact of TNF-α and IL-1β on the inflammatory phenotype of CAFs and MSCs by ... DisGeNET Detail
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Together, our findings defined an IL-1β-miR-101-Lin28B pathway as a novel regulatory axis of pathoge... DisGeNET Detail
Supporting this, meta-analysis of gene expression from human RCC tumors showed IL1B expression to co... DisGeNET Detail

Overlapped Transcript Coordinates

Gene Transcript ID Exon Number Chromosome Start Stop Type Amino Mutation Transcript Position Links

Overlapped Transcript

Gene Transcript ID Chromosome Start Stop Links
Gene
-
dbSNP
rs1801200 dbSNP
Genome
hg19
Position
chr2:113,587,328-113,594,356
Variant Type
snv
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