retinal degeneration
Information
- Disease name
- retinal degeneration
- Disease ID
- DOID:8466
- Description
- "A retinal disease that is characterized by deterioration of the retina caused by the progressive and eventual death of the cells of the retina." [url:https\://en.wikipedia.org/wiki/Retinal_degeneration_(rhodopsin_mutation)]
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
| Genes | Mutation | Description | Source | Links |
|---|
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT03894020 | Active, not recruiting | GTSCOPE - To Evaluate the Natural Progression of Dry Age-related Macular Degeneration (AMD) | January 8, 2019 | March 2, 2024 | |
| NCT01736293 | Active, not recruiting | Natural History of Eye Diseases Related to ABCA4 Mutations | October 9, 2012 | ||
| NCT04765345 | Active, not recruiting | Rate of Progression of PCDH15-Related Retinal Degeneration in Usher Syndrome 1F | June 8, 2021 | April 1, 2025 | |
| NCT03846193 | Active, not recruiting | Phase 1/Phase 2 | FOCUS: A Phase I/II First in Human Study to Evaluate the Safety and Efficacy of GT005 Administered in Subjects With Dry AMD | December 17, 2018 | June 28, 2024 |
| NCT03872479 | Active, not recruiting | Phase 1/Phase 2 | Single Ascending Dose Study in Participants With LCA10 | September 26, 2019 | May 23, 2025 |
| NCT00643747 | Completed | Phase 1/Phase 2 | Safety Study of RPE65 Gene Therapy to Treat Leber Congenital Amaurosis | January 2007 | December 2014 |
| NCT00877032 | Completed | Phase 1 | Safety And Tolerability Study Of RN6G In Patients With Dry, Age-Related Macular Degeneration | April 2009 | July 2011 |
| NCT01003691 | Completed | Phase 1 | Safety And Tolerability Study Of RN6G In Subjects With Advanced Dry, Age-Related Macular Degeneration Including Geographic Atrophy | August 5, 2010 | April 19, 2013 |
| NCT01024803 | Completed | N/A | Safety and Efficacy of Subretinal Implants for Partial Restoration of Vision in Blind Patients | December 2009 | April 2018 |
| NCT01024998 | Completed | Phase 1 | Safety and Tolerability Study of AAV2-sFLT01 in Patients With Neovascular Age-Related Macular Degeneration (AMD) | January 11, 2010 | July 2018 |
| NCT00001164 | Completed | Studies of Patients With Skin Disease, Patients With Neurological Degenerations, and Normal Volunteers | July 1978 | June 2000 | |
| NCT01399515 | Completed | Phase 2 | Efficacy and Safety of Oral Valproic Acid for Retinitis Pigmentosa | March 2011 | November 2015 |
| NCT00231010 | Completed | Molecular Genetics of Retinal Degenerations | September 26, 2005 | June 23, 2016 | |
| NCT00403195 | Completed | Clinical and Pathophysiological Description of Ocular Ischemic Syndrome | November 2006 | January 2009 | |
| NCT00746668 | Completed | N/A | A Multi-Center Study of Reading Rehabilitation in Macular Disease | August 2008 | September 2012 |
| NCT01494805 | Completed | Phase 1/Phase 2 | Safety and Efficacy Study of rAAV.sFlt-1 in Patients With Exudative Age-Related Macular Degeneration | December 2011 | August 2017 |
| NCT01497379 | Completed | N/A | Safety & Efficacy of Subretinal Implants for Partial Restoration of Vision in Blind Patients | October 2011 | January 2015 |
| NCT03954626 | Completed | Phase 3 | Study to Collect Safety and ECG Data on Brolucizumab 6 mg Intravitreal Treatment in Patients With Wet AMD | June 7, 2019 | July 31, 2019 |
| NCT02157077 | Completed | Phase 3 | Aflibercept After Ranibizumab in Exudative Age-related Macular Degeneration | December 2013 | December 2015 |
| NCT02330978 | Completed | Phase 1 | Intravitreal Mesenchymal Stem Cell Transplantation in Advanced Glaucoma. | January 2014 | September 2016 |
| NCT02543229 | Completed | Phase 1 | Study Evaluating the Safety, Pharmacokinetics and Pharmacodynamics of OPT-302 With or Without Lucentis™ in Patients With Wet AMD | July 2015 | September 2017 |
| NCT04945772 | Completed | Phase 2 | Efficacy and Safety of MCO-010 Optogenetic Therapy in Adults With Retinitis Pigmentosa [RESTORE] | July 13, 2021 | January 18, 2024 |
| NCT02814435 | Completed | Quality of Life Measures in Patients With Retinal Degeneration | July 2016 | October 2017 | |
| NCT04919473 | Completed | Phase 1/Phase 2 | Dose-Escalation Study to Evaluate the Safety and Tolerability of Intravitreal vMCO-I in Patients With Advanced Retinitis Pigmentosa | October 23, 2019 | October 31, 2020 |
| NCT03150654 | Completed | N/A | The Effect of Laser Treatment on Macular Pigment of Eye in Cases With Diabetes | October 1, 2015 | July 12, 2016 |
| NCT03318549 | Completed | N/A | BCI and Evaluation of Visual and Task Performance in Subjects With Eye Diseases | October 29, 2018 | May 31, 2023 |
| NCT03321253 | Completed | N/A | Changes of Macular Pigment and Parameters of Eyes After YAG Laser Treatment in Cases With Capsule Opacification | October 23, 2015 | May 16, 2016 |
| NCT03396042 | Completed | Natural History Study of CEP290-Related Retinal Degeneration | December 17, 2017 | May 6, 2022 | |
| NCT03843840 | Completed | Dual Wavelength OCT | February 15, 2019 | October 21, 2020 | |
| NCT04246866 | Completed | Phase 1 | First in Human Study to Evaluate the Safety and Tolerability of GEM103 in Geographic Atrophy Secondary to Dry Age Related Macular Degeneration | December 19, 2019 | October 21, 2020 |
| NCT04115917 | Completed | N/A | Evaluation of Discomfort Associated With Scleral Depression During Retina Examinations | January 1, 2018 | January 31, 2019 |
| NCT00125632 | Completed | N/A | Measuring Reading Rehabilitation Outcomes | August 2005 | May 2008 |
| NCT06167642 | Enrolling by invitation | Retinal Atrophy and Neurofilament Light Chain in People With Multiple Sclerosis Taking Ofatumumab | May 22, 2023 | June 2025 | |
| NCT05921162 | Enrolling by invitation | A Long-Term Follow-Up Study in Subjects Who Received vMCO-I Administered Via Intravitreal Injection | July 14, 2023 | December 2024 | |
| NCT06162585 | Enrolling by invitation | Non-Interventional Long Term Follow-up Study of Participants Previously Enrolled in the RESTORE Study | December 8, 2023 | September 2027 | |
| NCT06455826 | Not yet recruiting | Phase 1 | MAD of IVT VP-001 in PRPF31 Mutation-Associated Retinal Dystrophy Subjects (Wallaby) | June 2024 | November 2025 |
| NCT06185517 | Not yet recruiting | N/A | Validation of Questionnaire in Retinal Degeneration | January 2024 | January 2025 |
| NCT05797896 | Recruiting | Investigating Geographic Atrophy Insights (i-GAIN) Natural History Study | February 7, 2023 | December 31, 2026 | |
| NCT04545736 | Recruiting | Phase 1/Phase 2 | Oral Metformin for Treatment of ABCA4 Retinopathy | November 23, 2020 | August 31, 2027 |
| NCT02617966 | Recruiting | Rod and Cone Mediated Function in Retinal Disease | March 24, 2016 | December 30, 2029 | |
| NCT05283941 | Recruiting | N/A | Pistachios and Neural Macular Pigment | June 10, 2022 | November 30, 2023 |
| NCT05355415 | Recruiting | Adaptive Optics Imaging of Outer Retinal Diseases | August 27, 2021 | April 25, 2024 | |
| NCT05474729 | Recruiting | Phase 1/Phase 2 | Minocycline for Chronic Autoimmune Uveitis | December 1, 2021 | December 31, 2026 |
| NCT06011798 | Recruiting | Phase 2 | Assess the Efficacy and Safety of Repeat Intravitreal Injections of Foselutoclax (UBX1325) in Patients With DME (ASPIRE) | August 23, 2023 | June 2025 |
| NCT04620876 | Recruiting | N/A | Bimodal and Coaxial High Resolution Ophtalmic Imaging | October 1, 2019 | October 15, 2024 |
| NCT01432847 | Recruiting | Cell Collection to Study Eye Diseases | September 7, 2011 | ||
| NCT06289452 | Recruiting | Early Phase 1 | Safety and Efficacy Study of IVB102 Injection in Subjects With X-linked Retinoschisis | March 8, 2024 | December 31, 2029 |
| NCT06305416 | Recruiting | Phase 3 | A Efficacy and Safety Study of Ranibizumab 10mg/ml Injection (Incepta) in Patients With Diabetic Macular Edema | March 30, 2024 | April 2025 |
| NCT02348359 | Terminated | Phase 2 | X-82 to Treat Age-related Macular Degeneration | March 16, 2015 | January 12, 2018 |
| NCT03561922 | Terminated | N/A | Impact on Daily Life of Patients Using the Subretinal Implant RETINA IMPLANT Alpha AMS | September 4, 2018 | April 5, 2019 |
| NCT04295304 | Terminated | N/A | NR600 System Retinal Prosthesis for Patients With Retinal Degenerative Diseases | January 17, 2020 | March 12, 2023 |
| NCT04684394 | Terminated | Phase 2 | A Multiple Dose Study of Repeat Intravitreal Injections of GEM103 in Neovascular Age-related Macular Degeneration | December 29, 2020 | February 18, 2022 |
| NCT04643886 | Terminated | Phase 2 | A Multiple Dose Study of Repeat Intravitreal Injections of GEM103 in Dry Age-related Macular Degeneration | July 30, 2020 | March 21, 2022 |
| NCT03772938 | Unknown status | Phase 1 | Stem Cells Therapy in Degenerative Diseases of the Retina | December 13, 2018 | March 31, 2020 |
| NCT04128150 | Unknown status | High Resolution Retina Imaging | January 17, 2018 | January 30, 2024 | |
| NCT04129021 | Unknown status | N/A | Multimodal Ophthalmic Imaging | July 15, 2019 | June 30, 2023 |
| NCT03592017 | Unknown status | N/A | Performance of Long-wavelength Autofluorescence Imaging | October 1, 2018 | July 30, 2022 |
| NCT04855045 | Unknown status | Phase 2/Phase 3 | An Open-label, Dose Escalation and Double-masked, Randomized, Controlled Trial Evaluating Safety and Tolerability of Sepofarsen in Children (<8 Years of Age) With LCA10 Caused by Mutations in the CEP290 Gene. | March 23, 2021 | December 2023 |
| NCT03078309 | Unknown status | Early Phase 1 | The Effects of Cannabis on Visual Functions in Healthy and Retinitis Pigmentosa Patients | September 1, 2018 | December 2021 |
| NCT02144103 | Unknown status | Phase 1/Phase 2 | Effectiveness and Safety of Adipose-Derived Regenerative Cells for Treatment of Glaucomatous Neurodegeneration | May 2014 | January 2019 |
| NCT01278277 | Unknown status | Phase 1/Phase 2 | Saffron Supplementation in Stargardt's Disease | February 2011 | December 2017 |
| NCT03760055 | Unknown status | Assessment of Visual Function With a Portable Brain-computer Interface | February 11, 2019 | January 2024 |
- Disase is a (Disease Ontology)
- DOID:9799
- Cross Reference ID (Disease Ontology)
- MESH:D012162
- Cross Reference ID (Disease Ontology)
- NCI:C34979
- Cross Reference ID (Disease Ontology)
- SNOMEDCT_US_2023_03_01:95695004
- Cross Reference ID (Disease Ontology)
- UMLS_CUI:C0035304
- Exact Synonym (Disease Ontology)
- degeneration of retina
- HPO alt_id (Human Phenotype Ontology)
- HP:0007632
- HPO alt_id (Human Phenotype Ontology)
- HP:0007790
- HPO alt_id (Human Phenotype Ontology)
- HP:0007863
- HPO alt_id (Human Phenotype Ontology)
- HP:0007893
- HPO Human Phenotype ID (Human Phenotype Ontology)
- HP:0000546
- MeSH unique ID (MeSH (Medical Subject Headings))
- D012162