Pruritus

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Information
Disease name
Pruritus
Disease ID
Description
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
Genes Mutation Description Source Links
NCT ID Status Phase Summary Start date Completion date
NCT04950127 Active, not recruiting Phase 3 Global Linerixibat Itch Study of Efficacy and Safety in Primary Biliary Cholangitis (PBC) (GLISTEN) August 27, 2021 January 8, 2025
NCT05525520 Active, not recruiting Phase 2 Study to Evaluate EP547 in Subjects With Cholestatic Pruritus Due to Primary Biliary Cholangitis or Primary Sclerosing Cholangitis October 6, 2022 September 2024
NCT05448170 Available Linerixibat Compassionate Use for Cholestatic Pruritus Adult Patients With Primary Biliary Cholangitis (PBC)
NCT00257582 Completed Phase 3 Study Of Cutaneous Disease Accompanied With Pruritus In Pediatrics August 2005
NCT00261079 Completed Phase 4 Fexofenadine in Pruritic Skin Disease April 2005 October 2006
NCT00330343 Completed Phase 2 Optimal Dose of Prophylactic Naloxone in Reducing Opioid-Induced Side Effects in Children/Adolescents May 2004 June 2009
NCT00442819 Completed Phase 4 Uremic Pruritus, Cytokines and Polymethylmethacrylate Artificial Kidney July 2006 September 2006
NCT00568204 Completed N/A Study of Effectiveness of Mexyn-A March 2002 September 2005
NCT00745199 Completed Phase 2 Evaluating the Effect of Cromolyn Sodium in Uremic Pruritus May 2008 June 2009
NCT00762983 Completed Observation of Use of Claritin (Loratadine) Tablet, RediTabs, and Dry Syrup in Children (Study P05834)(COMPLETED) March 2008 February 2009
NCT00782054 Completed Phase 4 Evaluation of Post Burn Rehabilitation Population for Itch Control September 2006 April 2008
NCT00884325 Completed Phase 4 Management of Pruritus With Xyzal in Atopic Dermatitis February 2009 January 2010
NCT01055236 Completed Phase 4 Hydroxyzine for the Prevention of Pruritus From Spinal Morphine in Transabdominal Hysterectomy Patients August 2007 October 2008
NCT01071057 Completed Phase 2/Phase 3 Naloxone for the Treatment of Opioid-Induced Pruritus December 2010 April 2013
NCT01232985 Completed Phase 2 Efficacy and Tolerability Study of Device, RD047-26 for the Treatment of Mild to Moderate Atopic Dermatitis in Adults October 2010 December 2010
NCT01236859 Completed N/A Gabapentin for Prophylaxis Intrathecal Morphine-Induced Pruritus September 2009 November 2010
NCT04706975 Completed Phase 2 Study to Evaluate the Efficacy and Safety of Oral Difelikefalin (CR845) for Moderate to Severe Pruritus in Subjects With Notalgia Paresthetica (KOMFORT) January 11, 2021 June 30, 2022
NCT00058903 Completed Phase 2 Treatment of Cholestatic Pruritus With Sertraline April 2003 March 2005
NCT00215280 Completed N/A Epidemiology and Control of Mansonella Perstans Infection in Uganda November 2005 February 2006
NCT03477058 Completed N/A In-Use Test With a Cosmetic Product to Treat Pruritus January 23, 2017 February 6, 2017
NCT03483870 Completed Phase 2 Effect of Granisetron on Morphine Induced Pruritus in Cesarean Section June 1, 2018 October 30, 2020
NCT03490877 Completed Scratch and Sleep Quantification in Atopic Dermatitis July 13, 2018 September 30, 2019
NCT03546816 Completed Phase 3 Study of the Efficacy, Safety and Tolerability of Serlopitant for the Treatment of Pruritus (Itch) With Prurigo Nodularis May 2, 2018 February 14, 2020
NCT03617536 Completed Phase 2 A Study to Evaluate the Safety and Efficacy of CR845 in Chronic Kidney Disease Patients With Moderate-to-Severe Pruritus July 5, 2018 November 14, 2019
NCT03673878 Completed Prevalence of a Localized or Diffuse Pruritus in a Population With One or Several, Primitive or Secondary, Brain Tumor(s) June 29, 2020 September 5, 2021
NCT03677401 Completed Phase 3 Study of the Efficacy, Safety and Tolerability of Serlopitant for the Treatment of Pruritus (Itch) With Prurigo Nodularis August 29, 2018 February 6, 2020
NCT03701971 Completed N/A Study Evaluating the Benefit of Music Therapy on Pruritus in Patients With Pruritic Dermatitis November 8, 2018 April 19, 2019
NCT03796052 Completed N/A Study Determining Safety and Efficacy of Avena Sativa (Oat) Skincare Products for Treating Skin Dryness and Itching in Cancer Patients May 23, 2019 December 18, 2019
NCT03798561 Completed Phase 1 Study to Evaluate ASN008 Topical Gel (TG) January 14, 2019 March 20, 2020
NCT03824886 Completed N/A Enhancing SKIN Health and Safety in Aged CARE October 1, 2018 June 4, 2021
NCT03832140 Completed Frequency and Characteristics of Pruritus in Patients With Monoclonal Gammopathy May 24, 2019 November 19, 2019
NCT03841331 Completed Phase 2 Study of the Efficacy, Safety, and Tolerability of Serlopitant for the Treatment of Chronic Pruritus of Unknown Origin January 22, 2019 January 21, 2020
NCT03857568 Completed Phase 1 A Trial of SHR0410 Injection in Hemodialysis Participants. April 15, 2019 November 8, 2019
NCT03928223 Completed The Color of Itch; Itch Modification by Color Viewing March 1, 2017 August 31, 2018
NCT03997851 Completed Phase 1/Phase 2 Topical Acetaminophen for Itch Relief: a Proof of Concept Study in Healthy Subjects July 22, 2019 March 18, 2020
NCT04018027 Completed Phase 2 Study to Evaluate the Efficacy and Safety of Oral Difelikefalin (CR845) for Moderate to Severe Pruritus in Subjects With Atopic Dermatitis June 29, 2019 April 1, 2021
NCT04099927 Completed Phase 1 A Study of SHR4010 in Patients With Hemodialysis July 28, 2019 June 15, 2020
NCT04289038 Completed N/A The Efficacy of VR and AR on Pruritus April 1, 2021 February 26, 2022
NCT04326738 Completed Early Phase 1 The Effect of Midazolam on Dexamethasone-induced Perineal Pruritus January 16, 2020 December 30, 2020
NCT04337073 Completed Early Phase 1 The Effect of Propofol on Dexamethasone-induced Perineal Pruritus September 1, 2020 November 30, 2020
NCT04365244 Completed Pruritus and Melanoma and Cutaneous Carcinomas Treated With Immunotherapy August 19, 2019 November 22, 2019
NCT04396977 Completed N/A Inter-arm and Inter-period Reproducability of the Dermal Blood Flow Response After a Histamine Skin Prick. February 28, 2019 May 7, 2019
NCT04399148 Completed N/A Influence of Antipruritics on the Dermal Blood Flow Response to Histamine, Cinnamaldehyde and Capsaicin. June 11, 2019 September 23, 2019
NCT04399213 Completed N/A Dermal Blood Flow Response to Escalating Doses of Histamine, Administered by a Skin Prick January 15, 2019 February 19, 2019
NCT04399525 Completed N/A Influence of H1-antihistamines on the Dermal Blood Flow Response to Histamine, Cinnamaldehyde and Capsaicin. October 28, 2019 March 12, 2020
NCT04415034 Completed Scalp Pruritus Measurement Using Visual Analog Scale and 5-d Itch Scale in Children With Pediculosis Capitis September 1, 2018 September 30, 2018
NCT04510090 Completed Phase 1 Evaluate the Safety, Tolerability, and PK of EP547 in Healthy Subjects and Subjects With Cholestatic or Uremic Pruritus September 7, 2020 July 8, 2021
NCT00058890 Completed Phase 3 Gabapentin to Treat Itch in Patients With Liver Disease November 2000 January 2004
NCT04745429 Completed N/A Non-pharmacological Mitigation of Psoriasis February 19, 2020 October 6, 2020
NCT04999787 Completed Phase 2 A Clinical Trial Evaluating the Efficacy, Safety, and Pharmacokinetics of HSK21542 Injection in Liver Disease Subjects With Pruritus September 16, 2021 August 3, 2022
NCT05038982 Completed Phase 2 Efficacy of Abrocitinib for Reducing Pruritus in Adults With Prurigo Nodularis and Chronic Pruritus of Unknown Origin September 9, 2021 July 11, 2022
NCT05133830 Completed Phase 1 Linerixibat and Obeticholic Acid Drug Interaction Study in Healthy Adult Participants November 23, 2021 May 31, 2022
NCT05180968 Completed Phase 3 DIalysis Symptom COntrol-Pruritus Outcome Trial August 2, 2022 August 11, 2023
NCT05287724 Completed Early Phase 1 Defining N-Acetyl Cysteine as a Treatment for Inhibiting Prurogenic Stimuli June 19, 2022 January 4, 2024
NCT05393076 Completed Phase 1 Phase I Study of Linerixibat in Adults With Moderate Hepatic Impairment and Healthy Controls July 19, 2022 December 6, 2022
NCT05435170 Completed Phase 1 Food Effect Study of Linerixibat Tablets in Healthy Adult Participants August 11, 2022 October 10, 2022
NCT05461456 Completed Phase 1 Bioavailability and Tolerability of Fexofenadine Hydrochloride Topical Lotion 1% April 1, 2022 October 16, 2022
NCT05634083 Completed N/A Does Indoxyl Sulfate Have a Role in Uremic Pruritus? November 25, 2022 January 22, 2023
NCT05659823 Completed Phase 4 Postoperative Pain After Caesarian Section November 2, 2020 November 5, 2021
NCT05750875 Completed Phase 4 Gabapentin Versus Loratadine in Uremic Pruritus May 1, 2022 October 31, 2022
NCT05870865 Completed Phase 2 A Study to Evaluate the Anti-pruritic Effectiveness of ASN008 in Adults With Mild to Moderate Atopic Dermatitis May 3, 2023 December 28, 2023
NCT01586091 Completed Phase 4 Safety Study of Levocetirizine and Fexofenadine February 2011 February 2012
NCT01727180 Completed Pruritus in Patients With Chronic Kidney Disease June 2011 December 2013
NCT01795079 Completed N/A Effects of Transcranial Direct Current Stimulation (tDCS) on Neuropathic Symptoms Following Burn Injury January 2013 April 15, 2020
NCT01897428 Completed Phase 1 PK Comparisons of Bepotastine Besilate 10 mg and Bepotastine Salicylate 9.64 mg April 2011 August 2011
NCT01905631 Completed Phase 2 Blinded, Randomized Study Evaluating Aurstat Versus Control in the Treatment of Atopic Dermatitis Associated Pruritus July 2013 September 2013
NCT01919944 Completed Phase 1 Study of Itch Control by VLY-686 in Healthy Volunteers After Intradermal Injections of Substance P August 2013 November 2013
NCT01963793 Completed Phase 2 Topical Aprepitant in Prurigo Patients October 2013 July 2014
NCT02001948 Completed Phase 4 Intrathecal Morphine for Inguinal Hernia Repair. July 2009 July 2010
NCT02008864 Completed N/A Evaluating the Effect of Senna in Uremic Pruritus August 2011
NCT02143648 Completed Phase 2/Phase 3 Study of Nalbuphine HCl ER Tablets in Hemodialysis Patients With Uremic Pruritus June 2014 July 2015
NCT02143973 Completed Phase 2/Phase 3 Open Label Extension Study of Nalbuphine HCl ER in Hemodialysis Patients With Uremic Pruritus September 2014 January 2016
NCT02174419 Completed Phase 2/Phase 3 Study of Nalbuphine HCl ER Tablets in Patients With Prurigo Nodularis March 2015 August 2016
NCT02229929 Completed Phase 2 Safety and Pharmacokinetics of IV CR845 in Hemodialysis Patients, and Its Efficacy in Patients With Uremic Pruritus July 2014 July 2015
NCT02277678 Completed Phase 3 Comparison of Epidural Oxycodone and Epidural Morphine August 2013 December 2014
NCT02475447 Completed Phase 2 Safety, Pharmacokinetics and Preliminary Efficacy of Asimadoline in Pruritus Associated With Atopic Dermatitis July 2015 June 2017
NCT02558738 Completed Non Interventional Clinical Investigation of Ectoin Ear Spray in Skin Treatment of Outer Ear Canal Irritations June 2015 September 2015
NCT02639052 Completed Phase 1/Phase 2 Itch Relieving Effect of Botox: a Study in Healthy Subjects February 2016 January 2017
NCT02650076 Completed Phase 1 A Study to Investigate the Receptor Occupancy of SK-1405 in Healthy, Caucasian, Male Subjects January 2016
NCT02653703 Completed N/A L-menthol as a Topical Counter-irritant to TRPA1-induced Neurogenic Inflammation and Pain October 2014 December 2014
NCT02654483 Completed Phase 2 Neurokinin-1 Receptor Antagonist for the Treatment of Itch in EB Patients August 31, 2016 July 27, 2018
NCT02671162 Completed Phase 2 Evaluating the Effect of Fumaria Parviflora L. in Uremic Pruritus July 2015 January 2016
NCT02769910 Completed Phase 1/Phase 2 Effects of High-concentration Topical Capsaicin on Histaminergic and Non-histaminergic Itch May 2016 July 2016
NCT02793843 Completed N/A Ondansetron vs Ondansetron Plus Dexamethasone for Relieving Intrathecal Morphine Side Effects After C-section June 2016 July 30, 2017
NCT02823067 Completed Pruritus and Pemphigoid in Nursing Home Patients June 1, 2016 January 1, 2018
NCT02846181 Completed Phase 1 A Study to Assess the Mass Balance Recovery, Metabolite Profile and Metabolite Identification of [14C]-SK-1405 July 2016 August 2016
NCT02975206 Completed Phase 2 Study of the Efficacy, Safety, and Tolerability of Serlopitant for Pruritus (Itch) in Atopic Dermatitis November 2016 February 23, 2018
NCT03035942 Completed Phase 4 Quality of Recovery After Dexamethasone, Ondansetron or Placebo Intrathecal Morphine Administration January 2, 2017 November 4, 2019
NCT03209427 Completed Phase 4 Serum Serotonin and Pruritus After Intrathecal Morphine in Cesarean Section April 2, 2014 September 21, 2016
NCT03290989 Completed Itch and Pain Characteristics in Skin Carcinomas April 1, 2015 July 31, 2015
NCT03297580 Completed Itch and Clinacal Caracteristics in Systemic Sclerosis February 1, 2016 March 31, 2016
NCT03317301 Completed Phase 3 Evaluate the Efficacy and Safety of HL151 Versus Talion Tab. in Pruritus Cutaneus May 17, 2017 January 30, 2018
NCT03322137 Completed Phase 2 Safety, Efficacy, and Tolerability of SNA-120 in Subjects With Pruritus Associated With Psoriasis Vulgaris October 10, 2017 October 22, 2018
NCT03343639 Completed Phase 2 Study of the Efficacy, Safety and Tolerability of Serlopitant for the Treatment of Pruritus (Itch) With Plaque Psoriasis November 1, 2017 November 12, 2018
NCT03448081 Completed Phase 2 Safety, Tolerability and Efficacy of SNA-120 for Treatment of Pruritus and Psoriasis in Subjects Treated With Calcipotriene February 12, 2018 December 10, 2018
NCT03458572 Completed N/A Acupuncture for Prevention of Itch in Caesarean Section February 12, 2018 November 15, 2018
NCT05678309 Not yet recruiting Establishment of a Patient Library in Patients With Pruritus Sine Materia April 1, 2023 February 1, 2033
NCT06435299 Not yet recruiting Phase 3 Efficacy and Tolerance of Cannabidiol in Patients With Severe Pruritus: a Multicenter, Double-blind, Randomized, Placebo-controlled Study July 1, 2024 September 28, 2024
NCT06290375 Not yet recruiting Phase 2 A Study of HSK21542 in a Peritoneal Dialysis Pruritus Population. March 8, 2024 April 11, 2025
NCT04805073 Recruiting Phase 4 Treatment of Pruritus With Intramuscular Promethazine August 9, 2021 June 30, 2025
NCT06334679 Recruiting N/A The Effect of Cold Gel Pack Application on Itching in Burn Patients in the Maturation Stage January 15, 2024 December 15, 2024
NCT05779150 Recruiting N/A Efficacy of CeraVe® Moisturizing Cream on Skin Pruritus in Elderly Patients February 26, 2023 February 3, 2024
NCT05263206 Recruiting Phase 3 Efficacy and Safety of Subcutaneous Dupilumab for the Treatment of Adult Participants With Chronic Pruritus of Unknown Origin (CPUO) (LIBERTY-CPUO-CHIC) February 15, 2022 October 3, 2025
NCT05978063 Recruiting Phase 2/Phase 3 Study to Evaluate the Efficacy and Safety of Oral Difelikefalin for Moderate to Severe Pruritus in Subjects With Notalgia Paresthetica August 1, 2023 May 2026
NCT04256759 Recruiting Phase 2 Dupilumab for the Treatment of Moderate to Severe Chronic Hepatic Pruritus September 1, 2020 May 2025
NCT06120907 Recruiting Swiss Itch Registry October 18, 2023 October 2033
NCT06225323 Recruiting N/A Effect of Lidocaine Infusion on Neuraxial Opioid-induced Pruritus After Cesarean Section January 29, 2024 May 1, 2024
NCT05500794 Recruiting N/A Meditation in Inflammatory Dermatosis November 15, 2022 May 15, 2025
NCT06446609 Recruiting Drug-induced Liver Injury: Itching Study June 14, 2024 May 2028
NCT05604469 Recruiting The Role of Skin Microbiota in Hepatic or Renal Pruritus October 1, 2022 June 1, 2023
NCT01625455 Terminated Phase 4 Effect of Neurokinin-1 Receptor (NK1R) Antagonism on Pruritus in Patients With Sezary Syndrome February 2012 July 2016
NCT03262038 Terminated Phase 4 Does IV Ondansetron Prevent Pruritus After Intrathecal Morphine in Pediatric Patients? December 7, 2017 August 20, 2019
NCT03540160 Terminated Phase 3 Study of the Long Term Safety of Serlopitant for the Treatment of Pruritus (Itch) March 15, 2018 June 17, 2020
NCT01825655 Terminated Phase 4 Study of Using Long Acting Antihistamine to Treat Opioid Induced Itching September 2014 November 2017
NCT03096444 Terminated Phase 2 Antipruritic Effect of Topical Ketamine, Amitriptyline, and Lidocaine May 23, 2017 July 21, 2017
NCT05342623 Terminated Phase 3 A Study to Evaluate the Safety and Efficacy of Difelikefalin in Advanced Chronic Kidney Disease Patients With Moderate-to-Severe Pruritus May 17, 2022 February 29, 2024
NCT02975271 Terminated Phase 2 Study of the Efficacy, Safety & Tolerability of Serlopitant for Pruritus (Itch) After Burn Injury November 2016 January 17, 2017
NCT05356403 Terminated Phase 3 CR845-310302: A Study to Evaluate the Safety and Efficacy of Difelikefalin in Advanced Chronic Kidney Disease Patients With Moderate-to-Severe Pruritus August 26, 2022 February 26, 2024
NCT05387707 Terminated Phase 3 Study to Evaluate the Efficacy and Safety of Oral Difelikefalin as Adjunct Therapy to a Topical Corticosteroid for Moderate to Severe Pruritus in Subjects With Atopic Dermatitis August 16, 2022 February 2, 2024
NCT02247648 Terminated Phase 2 Efficacy of Extended-release, Once Daily Tramadol for Post Operative Analgesia in Shoulder Arthroscopy June 2013 December 2017
NCT05024851 Terminated Psychogenic and Neurogenic Components in Patients With Psychogenic or Neuropathic Pruritus August 25, 2021 July 8, 2022
NCT01605708 Terminated Phase 1/Phase 2 Study to Assess the Clinical Activity of a Sequential Dose of REGN846 on Refractory Pruritus in Patients With Atopic Dermatitis June 2012 April 2013
NCT04317209 Unknown status Phase 1 A Study of SHR0410 in Hemodialysis Patients With Pruritus May 17, 2020 December 2020
NCT01769144 Unknown status N/A Acticoat Absorbent and BCT Antimicrobial for STSG Donor Site on Thigh January 2013 April 2014
NCT03340155 Unknown status N/A Mechanisms of Action of Photo(Chemo)Therapy in Skin Diseases October 30, 2017 October 2022
NCT00715260 Unknown status An Observational Study of Pruritus Amongst Hemodialysis Patients December 2007 July 2008
NCT00577967 Unknown status N/A Gabapentin - A Solution to Uremic Pruritus? October 2005 March 2006
NCT04589429 Unknown status Phase 2 Adding Nalbuphine for Control of Intrathecal Morphine Pruritus October 15, 2020 March 2021
NCT02432508 Unknown status N/A Efficacy of Laser Acupuncture on Pruritus in Patients With Chronic Kidney Disease Undergoing Hemodialysis October 2014 December 2016
NCT04618146 Unknown status N/A Enhanced Recovery After Cesarean Section With Low Dose Intrathecal Morphine. November 10, 2020 March 2021
NCT05135390 Unknown status Phase 3 A Clinical Trial Evaluating the Efficacy and Safety of HSK21542 in Patients With Chronic Kidney Disease-Associated Pruritus December 2021 December 2022
NCT03132142 Unknown status N/A Desensitization of Nociceptive Afferents by Application of Topical Capsaicin, Trans-cinnamaldehyde and L-menthol April 2017 August 2017
NCT01265082 Unknown status Explore the Mechanisms of Pruritus in Bullous Pemphigoid Patients During Remission December 2010
NCT04325802 Withdrawn Phase 2 Treatment of Chronic Itch in Atopic Dermatitis With Opioid Antagonist Naltrexone December 31, 2022 June 2024
NCT03464526 Withdrawn Phase 2 A Study of the Efficacy and Safety of Orvepitant in Subjects With Pruritus Associated With Atopic Dermatitis May 2018 October 2019
NCT01801670 Withdrawn Impact of Vorinostat on Pruritus Signaling Pathways - Merck Study January 2015 January 2015
NCT04154033 Withdrawn Phase 2 Treatment of Chronic Itch in Atopic Dermatitis With Topical Naltrexone October 1, 2020 March 31, 2024
NCT01092520 Withdrawn Phase 1 Gabapentin for the Treatment of Pruritus Caused by Burn Injuries in Children July 2009 July 2011
HPO Human Phenotype ID (Human Phenotype Ontology)
HP:0000989
ICD10 preferred id (Insert disease from ICD10)
D0009733
ICD10 class code (Insert disease from ICD10)
L29
MeSH unique ID (MeSH (Medical Subject Headings))
D011537