chr17:7565097:> Detail (hg19)

Information

Genome

Assembly Position
hg19 chr17:7,565,097-7,590,864
hg38 chr17:7,661,779-7,687,546 

HGVS

Type Transcript Protein
Summary

MGeND

Clinical significance
Variant entry
GWAS entry
Disease area statistics Show details

Frequency

[No Data.]

Prediction

[No Data.]

ClinVar

Clinical Significance
Review star [No Data.]
Show details
Links
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
[No Data.]
CIViC
[No Data.]
DisGeNET
Score Disease name Description Source Pubmed Links
0.164 Carcinoma, Transitional Cell We also found significant inverse correlation between FGFR3 mutations and TP53 a... BeFree,CTD_human,GAD,LHGDN 25537218 Detail
0.164 Carcinoma, Transitional Cell Taken together, our results provide evidence for RTK/RAS pathway activation and ... BeFree,CTD_human,GAD,LHGDN 25795707 Detail
0.008 carcinosarcoma NA BeFree,LHGDN Detail
0.003 Cardiomyopathy, Dilated NA BeFree,LHGDN Detail
<0.001 Xeroderma Pigmentosum, Complementation Group D Specifically, 2 polymorphisms-an arginine-to-glutamine substitution at codon 399... BeFree 23096768 Detail
0.120 hypertrophic cardiomyopathy NA CTD_human Detail
0.006 Cardiovascular Diseases NA BeFree,GAD Detail
0.085 colorectal carcinoma Association between XRCC1 ARG399GLN and P53 ARG72PRO polymorphisms and the risk ... BeFree 21971103 Detail
0.125 Carotid Artery Diseases NA CTD_human,GAD,LHGDN Detail
0.080 Cecal Neoplasms NA CTD_mouse Detail
0.214 Neoplastic Cell Transformation NA CTD_human,CTD_mouse,GAD Detail
0.005 Cerebellar Neoplasms NA GAD Detail
<0.001 intracranial aneurysm NA BeFree Detail
0.120 brain ischemia NA CTD_human Detail
<0.001 Transient ischemic attack NA BeFree Detail
0.056 Malignant tumor of cervix Association of a miR-502-binding site single nucleotide polymorphism in the 3'-u... BeFree 25169478 Detail
0.056 Malignant tumor of cervix Several factors may contribute to cervical cancer (CC) development, including ge... BeFree 25181402 Detail
0.056 Malignant tumor of cervix The p53 target gene WIG-1 (ZMAT3) is located in chromosomal region 3q26, that is... BeFree 25379706 Detail
0.056 Malignant tumor of cervix Berberine alters epigenetic modifications, disrupts microtubule network, and mod... BeFree 25448308 Detail
0.056 Malignant tumor of cervix Thus, the polymorphism of p53 codon 72 in exon 4 does not seem to play a role in... BeFree 25502079 Detail
0.056 Malignant tumor of cervix Overexpression of Nm23H1 but not H2 also inhibited tumorigenesis by human cervic... BeFree 25748386 Detail
0.056 Malignant tumor of cervix The mechanism and inhibitory effect of recombinant human P53 adenovirus injectio... BeFree 25855930 Detail
0.160 Malignant neoplasm of lung Therefore, we hypothesized that the genetic variants in these three genes influe... BeFree 16912209 Detail
0.001 Cervix Diseases NA BeFree Detail
0.003 Cervical dysplasia NA BeFree,GAD Detail
0.090 Uterine Cervical Neoplasm NA BeFree,GAD,LHGDN Detail
0.003 cheilitis NA BeFree,LHGDN Detail
<0.001 cholangitis NA BeFree Detail
<0.001 Primary biliary cirrhosis NA BeFree Detail
0.005 cholecystitis NA BeFree,GAD,LHGDN Detail
<0.001 cholelithiasis NA BeFree Detail
<0.001 cholesteatoma NA BeFree Detail
<0.001 Chondromatosis, Synovial NA BeFree Detail
0.004 chondrosarcoma NA BeFree Detail
0.003 chordoma NA LHGDN Detail
0.160 colorectal cancer We have previously reported that the common, functionally different variants Arg... BeFree 17224235 Detail
0.004 choriocarcinoma NA BeFree,GAD Detail
0.017 Chromosome Aberrations NA GAD Detail
0.005 Hereditary Nonpolyposis Colorectal Cancer We have previously reported that the common, functionally different variants Arg... BeFree 17224235 Detail
0.005 Chromosome Deletion NA GAD Detail
0.005 Cocarcinogenesis NA GAD Detail
0.001 Cockayne syndrome NA BeFree Detail
0.002 colitis Here we showed first that in human IBD colonic samples and in murine colitis the... BeFree 25347196 Detail
0.027 ulcerative colitis Moreover, p53 is frequently mutated in the early stages of UC-associated cancer. BeFree,GAD,LHGDN 24944468 Detail
0.027 ulcerative colitis Patients with UC with presence of extraintestinal manifestations, complications,... BeFree,GAD,LHGDN 25076849 Detail
0.027 ulcerative colitis TP53/p53 alterations and Aurora A expression in progressor and non-progressor co... BeFree,GAD,LHGDN 25333414 Detail
<0.001 Congenital ocular coloboma (disorder) NA BeFree Detail
0.191 Colonic Neoplasms NA BeFree,CTD_human,GAD,LHGDN Detail
<0.001 Colonic Polyps NA BeFree Detail
0.085 colorectal carcinoma We have previously reported that the common, functionally different variants Arg... BeFree 17224235 Detail
0.080 Carcinoma of lung Therefore, we hypothesized that the genetic variants in these three genes influe... BeFree 16912209 Detail
0.248 Colorectal Neoplasms Inactivation of TP53 pathway by TP53 mutations is observed in nearly half of col... BeFree,CTD_human,GAD,LHGDN 25609485 Detail
0.248 Colorectal Neoplasms Multiplex Ligation-dependent Probe Amplification, TP53 sequencing, real-time pol... BeFree,CTD_human,GAD,LHGDN 25964555 Detail
0.005 Hereditary nonpolyposis colorectal neoplasms NA GAD,LHGDN Detail
<0.001 common cold We validated COLD-ddPCR on multiple mutations in TP53 and in EGFR using serial m... BeFree 25772705 Detail
0.004 Condylomata Acuminata NA BeFree,GAD Detail
0.002 Conjunctival Neoplasms NA GAD Detail
0.002 Coronary Arteriosclerosis NA BeFree Detail
0.003 Coronary heart disease NA BeFree,GAD Detail
0.160 colorectal cancer Association between XRCC1 ARG399GLN and P53 ARG72PRO polymorphisms and the risk ... BeFree 21971103 Detail
0.006 Crohn Disease NA BeFree,GAD,LHGDN Detail
0.261 Nasopharyngeal carcinoma The results suggested that the Arg399Gln polymorphism of XRCC1 gene, the 1G/2G p... BeFree 25481674 Detail
0.124 adenoid cystic carcinoma Downregulation of p53 promotes in vitro perineural invasive activity of human sa... BeFree,CTD_human 25625376 Detail
<0.001 cystadenocarcinoma NA BeFree Detail
0.001 cystadenoma NA BeFree Detail
<0.001 Cystadenoma, Mucinous NA BeFree Detail
<0.001 cystitis NA BeFree Detail
0.002 Phyllodes Tumor NA BeFree Detail
<0.001 Cyst NA BeFree Detail
<0.001 Cytomegalovirus Infections NA BeFree Detail
0.011 Cessation of life NA LHGDN Detail
<0.001 Presenile dementia NA BeFree Detail
0.080 Dementia, Vascular NA RGD Detail
0.120 Demyelinating Diseases NA CTD_human Detail
0.001 Dentigerous Cyst NA BeFree Detail
0.003 Mental Depression NA BeFree,GAD Detail
0.001 depressive disorder NA BeFree Detail
<0.001 dermatitis NA BeFree Detail
0.002 Dermatomycoses NA GAD Detail
<0.001 dermatomyositis NA BeFree Detail
<0.001 scleroderma NA BeFree Detail
0.001 dermoid cyst NA BeFree Detail
0.002 Diabetes These results uncover a new mechanism of p53 inactivation providing an interesti... BeFree 25260780 Detail
<0.001 diabetes insipidus NA BeFree Detail
0.005 diabetes mellitus These results uncover a new mechanism of p53 inactivation providing an interesti... BeFree,GAD 25260780 Detail
0.005 diabetes mellitus Reduced LRP6 expression and increase in the interaction of GSK3β with p53 contri... BeFree,GAD 25655048 Detail
0.280 Diabetes Mellitus, Experimental NA CTD_human,CTD_mouse,RGD Detail
0.008 Diabetes Mellitus, Insulin-Dependent NA BeFree,GAD,LHGDN Detail
0.003 Diabetes Mellitus, Non-Insulin-Dependent NA BeFree,GAD Detail
0.082 Diabetic Nephropathy NA GAD,RGD Detail
<0.001 Digestive System Disorders NA BeFree Detail
0.009 DNA Damage NA GAD Detail
0.005 Down syndrome In recent years, miR-1246 has been identified as a transcriptional target of p53... BeFree,GAD 25591821 Detail
0.005 Down syndrome Cell senescence was found to appear prematurely in DS cells as shown by SA-β-Gal... BeFree,GAD 25852816 Detail
<0.001 Drug abuse NA BeFree Detail
0.008 duodenal ulcer NA BeFree,GAD,LHGDN Detail
<0.001 Dwarfism NA BeFree Detail
<0.001 Dyspepsia NA BeFree Detail
0.002 Ehlers-Danlos syndrome NA GAD Detail
<0.001 Embolism, Tumor NA BeFree Detail
0.120 Pathological accumulation of air in tissues NA CTD_human Detail
<0.001 encephalitis NA BeFree Detail
<0.001 Experimental Autoimmune Encephalomyelitis NA BeFree Detail
<0.001 Yolk Sac Tumor NA BeFree Detail
0.125 Endometrial Neoplasms Further, Cdh1(d/d)Trp53(d/d) tumors in 12-month-old mice were highly aggressive,... BeFree,CTD_mouse,GAD,LHGDN 24998851 Detail
0.002 endometrial hyperplasia NA BeFree Detail
0.003 Ependymoma NA BeFree Detail
<0.001 Epithelial cyst NA BeFree Detail
0.007 epidermodysplasia verruciformis NA BeFree,GAD Detail
<0.001 epidermolysis bullosa NA BeFree Detail
0.003 Epilepsy, Temporal Lobe NA BeFree,LHGDN Detail
<0.001 Epithelial hyperplasia NA BeFree Detail
<0.001 Erythroplasia NA BeFree Detail
<0.001 Esophageal Achalasia NA BeFree Detail
<0.001 esophagitis NA BeFree Detail
0.002 Exanthema pERK expression may have an impact on OS in erlotinib-treated patients with adva... BeFree 25164437 Detail
0.002 Exanthema Polysomy 7, polysomy 18, p16 deletion, and p53 deletion were significantly more ... BeFree 25517961 Detail
0.002 Exanthema More than 50% of human cancers contain a mutation or deletion of the p53 gene, a... BeFree 26216949 Detail
0.004 Fanconi anemia Forty-two deleterious germline mutations were identified in 21 genes of 34 patie... BeFree 25927356 Detail
0.001 breast fibrocystic disease NA BeFree Detail
0.005 fibrosarcoma She presented with a clinical diagnosis of Li-Fraumeni-like syndrome (LFL), show... BeFree 25935441 Detail
0.003 Fibrosis NA LHGDN Detail
<0.001 pathologic fistula NA BeFree Detail
<0.001 Foot Diseases NA BeFree Detail
<0.001 Fuchs Endothelial Dystrophy NA BeFree Detail
<0.001 Gall Bladder Diseases NA BeFree Detail
0.125 gallbladder neoplasm NA CTD_human,GAD,LHGDN Detail
<0.001 gastrinoma NA BeFree Detail
0.016 gastritis However, there is increased apoptosis in gastritis which may occur independent o... BeFree,GAD,LHGDN 25422197 Detail
0.006 Gastritis, Atrophic NA BeFree,GAD Detail
<0.001 gastroesophageal reflux disease NA BeFree Detail
<0.001 Gastrointestinal Diseases NA BeFree Detail
0.005 Gastrointestinal Neoplasms NA GAD Detail
0.002 Genital Neoplasms, Female NA GAD Detail
0.004 Giant Cell Tumors NA BeFree,LHGDN Detail
0.003 glaucoma NA BeFree,GAD Detail
0.012 Glaucoma, Open-Angle NA BeFree,GAD Detail
0.329 Glioma Those tumors that lacked LOH 1p19q showed a high frequency of IDH1 mutations and... BeFree,CTD_human,CTD_mouse,GAD,LHGDN 24444336 Detail
0.329 Glioma Due to the structural homology between p53 and p73, a subtle balance among p53 f... BeFree,CTD_human,CTD_mouse,GAD,LHGDN 24742294 Detail
0.329 Glioma A total of 157 diffuse gliomas (World Health Organization grades II-IV) were ass... BeFree,CTD_human,CTD_mouse,GAD,LHGDN 25040820 Detail
0.329 Glioma Furthermore, AND did not induce apoptosis or activate ERK and p53 in primary cul... BeFree,CTD_human,CTD_mouse,GAD,LHGDN 25162007 Detail
0.329 Glioma Finally, p53 mutations correlated with alterations in ETC subunit composition an... BeFree,CTD_human,CTD_mouse,GAD,LHGDN 25583481 Detail
0.329 Glioma In support of the functional interaction between CD24 and p53, in silico analyse... BeFree,CTD_human,CTD_mouse,GAD,LHGDN 25600590 Detail
0.329 Glioma The effect of silibinin in enhancing toxicity of temozolomide and etoposide in p... BeFree,CTD_human,CTD_mouse,GAD,LHGDN 25750273 Detail
0.329 Glioma Nearly all lower-grade gliomas with IDH mutations and no 1p/19q codeletion had m... BeFree,CTD_human,CTD_mouse,GAD,LHGDN 26061751 Detail
0.003 IgA glomerulonephritis NA BeFree,LHGDN Detail
<0.001 goiter NA BeFree Detail
<0.001 nodular goiter NA BeFree Detail
0.002 Graft Occlusion, Vascular NA GAD Detail
<0.001 Graft-vs-Host Disease NA BeFree Detail
0.001 granulosa cell tumor NA BeFree Detail
0.006 Graves Disease NA BeFree,GAD Detail
<0.001 Hamartoma NA BeFree Detail
0.001 Hamartoma Syndrome, Multiple NA BeFree Detail
0.060 Head and Neck Neoplasms NA BeFree,GAD,LHGDN Detail
<0.001 cardiac arrest ECCCs had SCA-like features with rare expression of estrogen receptor/progestero... BeFree 25473756 Detail
0.003 Cardiomegaly NA LHGDN Detail
0.085 Heart failure NA BeFree,CTD_mouse,LHGDN Detail
0.002 congestive heart failure NA BeFree Detail
<0.001 hemangioma NA BeFree Detail
<0.001 hemangiopericytoma NA BeFree Detail
0.204 Hemangiosarcoma NA BeFree,CTD_human,CTD_mouse Detail
0.001 Hematological Disease NA BeFree Detail
<0.001 hemochromatosis NA BeFree Detail
<0.001 Hemorrhoids NA BeFree Detail
0.003 hepatitis One such example is hepatitis virus-induced liver cancer whereby p53 is inactiva... BeFree 25404244 Detail
0.003 hepatitis A One such example is hepatitis virus-induced liver cancer whereby p53 is inactiva... BeFree 25404244 Detail
0.037 hepatitis B Chronic infection with hepatitis B virus (HBV) and exposure to aflatoxin B1 (AFB... BeFree,GAD,LHGDN 24461059 Detail
0.037 hepatitis B Finally, in HBV-related HCC, transcriptomic profiles were associated with specif... BeFree,GAD,LHGDN 25021421 Detail
0.037 hepatitis B Hepatitis B Virus Core Promoter A1762T/G1764A (TA)/T1753A/T1768A Mutations Contr... BeFree,GAD,LHGDN 25567052 Detail
0.037 hepatitis B Associations of mutations defined 3 groups of genes related to risk factors and ... BeFree,GAD,LHGDN 25822088 Detail
0.037 hepatitis B Moreover, the HBV-MLL4 integration occurred almost exclusively in CTNNB1 and TP5... BeFree,GAD,LHGDN 25901726 Detail
0.037 hepatitis B Evaluation of CTNNB1 and TP53 variability in patients with hepatocellular carcin... BeFree,GAD,LHGDN 26341700 Detail
0.001 Hepatitis, Chronic NA BeFree Detail
0.020 hepatitis C NA BeFree,GAD,LHGDN Detail
<0.001 Hepatolenticular Degeneration NA BeFree Detail
0.001 Herpes NOS Results were correlated with immunoreactivity for USP7 (herpes virus-associated ... BeFree 25884169 Detail
0.009 Herpes Simplex Infections NA BeFree,GAD,LHGDN Detail
<0.001 Von Hippel-Lindau syndrome NA BeFree Detail
0.003 Histiocytosis, Langerhans-Cell NA BeFree,LHGDN Detail
0.010 HIV Infections Uncommon non-oncogenic HPV genotypes, TP53 and MDM2 genes polymorphisms in HIV-i... BeFree,GAD 25181402 Detail
0.010 HIV Infections Host restriction and associated viral latency have been studied for several deca... BeFree,GAD 25653431 Detail
0.008 Hodgkin Disease NA BeFree,GAD,LHGDN Detail
<0.001 HTLV-I Infections NA BeFree Detail
0.004 Huntington disease We assessed cellular manganese handling to test for correlations with the ATM-p5... BeFree,LHGDN 25489053 Detail
0.004 Hydatidiform mole NA BeFree,GAD Detail
<0.001 hyperglycemia NA BeFree Detail
0.011 Hyperplasia NA LHGDN Detail
0.120 Hypertensive disease NA BeFree,CTD_human Detail
<0.001 pulmonary hypertension NA BeFree Detail
<0.001 hypoglycemia NA BeFree Detail
0.008 Hypopharyngeal Neoplasms NA GAD,LHGDN Detail
<0.001 Angioimmunoblastic Lymphadenopathy NA BeFree Detail
0.002 Immunologic Deficiency Syndromes Genetic depletion of Snail1 in MSCs that are deficient in p53 tumor suppressor d... BeFree 24947186 Detail
0.003 Immunoproliferative Small Intestinal Disease NA BeFree,LHGDN Detail
0.125 Female infertility NA CTD_human,GAD Detail
0.124 male infertility NA BeFree,CTD_human,LHGDN Detail
0.001 Mammary Ductal Carcinoma NA BeFree Detail
0.008 Inflammation NA GAD,LHGDN Detail
0.006 Inflammatory Bowel Diseases Here we showed first that in human IBD colonic samples and in murine colitis the... BeFree,GAD,LHGDN 25347196 Detail
<0.001 influenza NA BeFree Detail
<0.001 insulinoma NA BeFree Detail
0.003 Intestinal Neoplasms NA BeFree,GAD Detail
0.202 ischemia Induction of p21 independently of p53 is also observed in transgenic mice overex... BeFree,CTD_human,RGD 24515317 Detail
<0.001 Kartagener syndrome NA BeFree Detail
0.009 Keloid NA BeFree,GAD,LHGDN Detail
0.008 keratoacanthoma NA BeFree,LHGDN Detail
0.132 keratosis NA BeFree,CTD_human,GAD,LHGDN Detail
0.016 actinic keratosis NA BeFree,LHGDN Detail
0.003 seborrheic keratosis NA LHGDN Detail
0.002 Kidney Diseases This study aimed to characterize the TP53 mutational spectrum in urothelial canc... BeFree 25184754 Detail
0.004 Kidney Failure, Acute NA BeFree Detail
<0.001 Kidney Failure, Chronic NA BeFree Detail
0.004 Kidney Neoplasm NA BeFree,GAD Detail
0.120 Vulvar Lichen Sclerosus NA BeFree,CTD_human Detail
0.013 Laryngeal neoplasm NA BeFree,GAD,LHGDN Detail
0.011 Fibroid Tumor NA BeFree,GAD,LHGDN Detail
0.007 leiomyosarcoma NA BeFree Detail
0.057 leukemia Li-Fraumeni syndrome is caused by germline TP53 mutations and is clinically char... BeFree,GAD,LHGDN 24810334 Detail
0.057 leukemia Lastly, we validate the effectiveness of ALX as a chemotherapeutic agent in vivo... BeFree,GAD,LHGDN 25132271 Detail
0.057 leukemia Expression of TP53 by CD34-positive cells was associated with shorter OS and leu... BeFree,GAD,LHGDN 26123119 Detail
0.057 leukemia The Role of TP53 Gene Codon 72 Polymorphism in Leukemia: A PRISMA-Compliant Syst... BeFree,GAD,LHGDN 26402821 Detail
0.347 chronic lymphocytic leukemia NOTCH1, SF3B1, BIRC3 and TP53 mutations in patients with chronic lymphocytic leu... BeFree,CTD_human,GAD,LHGDN,ORPHANET 24597984 Detail
0.347 chronic lymphocytic leukemia Through the European Research Initiative on chronic lymphocytic leukemia (CLL) (... BeFree,CTD_human,GAD,LHGDN,ORPHANET 24943832 Detail
0.347 chronic lymphocytic leukemia Sodium dichloroacetate exhibits anti-leukemic activity in B-chronic lymphocytic ... BeFree,CTD_human,GAD,LHGDN,ORPHANET 24962518 Detail
0.347 chronic lymphocytic leukemia Detailed analysis of therapy-driven clonal evolution of TP53 mutations in chroni... BeFree,CTD_human,GAD,LHGDN,ORPHANET 25287991 Detail
0.347 chronic lymphocytic leukemia From pioneering studies, we know that certain genetic events are found in the ma... BeFree,CTD_human,GAD,LHGDN,ORPHANET 25345442 Detail
0.347 chronic lymphocytic leukemia We first performed detailed genetic analyses in a CLL cohort (n=110) containing ... BeFree,CTD_human,GAD,LHGDN,ORPHANET 25371178 Detail
0.347 chronic lymphocytic leukemia TP53 mutation analysis in chronic lymphocytic leukemia: comparison of different ... BeFree,CTD_human,GAD,LHGDN,ORPHANET 25527155 Detail
0.347 chronic lymphocytic leukemia TP53 codon 72 single nucleotide polymorphism in chronic lymphocytic leukemia. BeFree,CTD_human,GAD,LHGDN,ORPHANET 25537220 Detail
0.347 chronic lymphocytic leukemia B-chronic lymphocytic leukemia (B-CLL) patients harboring p53 mutations are inva... BeFree,CTD_human,GAD,LHGDN,ORPHANET 25544776 Detail
0.347 chronic lymphocytic leukemia Ibrutinib for previously untreated and relapsed or refractory chronic lymphocyti... BeFree,CTD_human,GAD,LHGDN,ORPHANET 25555420 Detail
0.347 chronic lymphocytic leukemia The p53 transcriptional pathway is preserved in ATMmutated and NOTCH1mutated chr... BeFree,CTD_human,GAD,LHGDN,ORPHANET 25587027 Detail
0.347 chronic lymphocytic leukemia Frequencies of SF3B1, NOTCH1, MYD88, BIRC3 and IGHV mutations and TP53 disruptio... BeFree,CTD_human,GAD,LHGDN,ORPHANET 25605254 Detail
0.347 chronic lymphocytic leukemia TCL1 targeting miR-3676 is codeleted with tumor protein p53 in chronic lymphocyt... BeFree,CTD_human,GAD,LHGDN,ORPHANET 25646413 Detail
0.347 chronic lymphocytic leukemia Allogeneic hematopoietic stem cell transplantation (alloHSCT) has been considere... BeFree,CTD_human,GAD,LHGDN,ORPHANET 25651976 Detail
0.347 chronic lymphocytic leukemia Currently, these types of CLL are treated with approaches that do not target the... BeFree,CTD_human,GAD,LHGDN,ORPHANET 25724841 Detail
0.347 chronic lymphocytic leukemia In addition to miRNAs, the long non-coding RNAs (lncRNAs) nuclear enriched abund... BeFree,CTD_human,GAD,LHGDN,ORPHANET 25971364 Detail
0.001 hairy cell leukemia NA BeFree Detail
0.002 lymphoid leukemia NA BeFree Detail
0.015 Acute lymphocytic leukemia NA BeFree Detail
0.005 Leukemia, Lymphocytic, Acute, L1 NA BeFree Detail
<0.001 acute monocytic leukemia NA BeFree Detail
0.157 Leukemia, Myelocytic, Acute Strong p53 expression in ≥ 1% of bone marrow progenitor cells, observed in 35% (... BeFree,CTD_mouse,GAD,LHGDN 24682512 Detail
0.157 Leukemia, Myelocytic, Acute The regimen was active against patient-derived acute myelogenous leukemia (AML) ... BeFree,CTD_mouse,GAD,LHGDN 25283841 Detail
0.157 Leukemia, Myelocytic, Acute Results confirm high frequencies of RAS and other activated signaling mutations ... BeFree,CTD_mouse,GAD,LHGDN 25331116 Detail
0.157 Leukemia, Myelocytic, Acute MDM2 SNP309 and p53 codon 72 genetic polymorphisms and risk of AML: an Egyptian ... BeFree,CTD_mouse,GAD,LHGDN 25361931 Detail
0.157 Leukemia, Myelocytic, Acute Role of TP53 mutations in the origin and evolution of therapy-related acute myel... BeFree,CTD_mouse,GAD,LHGDN 25487151 Detail
0.157 Leukemia, Myelocytic, Acute Consistent with these data, expression of JAK2V617F combined with Tp53 loss led ... BeFree,CTD_mouse,GAD,LHGDN 25516983 Detail
0.157 Leukemia, Myelocytic, Acute TP53 mutations are highly and similarly prevalent in t-MDS and t-AML but mutatio... BeFree,CTD_mouse,GAD,LHGDN 25573287 Detail
0.157 Leukemia, Myelocytic, Acute Other mechanisms linked to PU.1 downregulation in human AML include TP53 deletio... BeFree,CTD_mouse,GAD,LHGDN 25750172 Detail
0.157 Leukemia, Myelocytic, Acute Mutations in FLT3, DNMT3A, NRAS, NF1 and TP53 occur in persons of predominately ... BeFree,CTD_mouse,GAD,LHGDN 25858894 Detail
0.157 Leukemia, Myelocytic, Acute TP53 mutation characteristics in therapy-related myelodysplastic syndromes and a... BeFree,CTD_mouse,GAD,LHGDN 25952993 Detail
0.014 myeloid leukemia NA BeFree,GAD,LHGDN Detail
0.024 Myeloid Leukemia, Chronic NA BeFree,GAD,LHGDN Detail
0.002 Leukemia, Myeloid, Chronic-Phase NA BeFree Detail
<0.001 Leukemia, Myelomonocytic, Chronic NA BeFree Detail
0.001 Leukemia, Plasma Cell NA BeFree Detail
0.001 Precursor B-Cell Lymphoblastic Leukemia-Lymphoma Indole-3-carbinol suppresses NF-κB activity and stimulates the p53 pathway in pr... BeFree 25589462 Detail
<0.001 prolymphocytic leukemia NA BeFree Detail
0.002 acute promyelocytic leukemia According to our results, the pharmacological inhibition of autophagy and p53 mu... BeFree 25322811 Detail
0.003 Leukemia, T-Cell NA BeFree Detail
0.007 Adult T-Cell Lymphoma/Leukemia NA BeFree Detail
0.005 Leukoencephalopathy, Progressive Multifocal NA BeFree,GAD Detail
<0.001 leukopenia NA BeFree Detail
0.009 Leukoplakia NA BeFree,GAD Detail
0.088 Leukoplakia, Oral NA BeFree,GAD,RGD Detail
<0.001 Leydig cell tumor NA BeFree Detail
0.007 Lichen Sclerosus et Atrophicus NA BeFree,LHGDN Detail
<0.001 mucopolysaccharidosis I NA BeFree Detail
0.001 lipoma NA BeFree Detail
0.006 liposarcoma NA BeFree Detail
0.012 liver cirrhosis NA BeFree,GAD,LHGDN Detail
0.004 Liver diseases NA BeFree,LHGDN Detail
0.120 Liver Diseases, Parasitic NA CTD_human Detail
0.184 Liver neoplasms An inverse correlation existed between miR-1228 and p53 expression in hepatoma t... BeFree,CTD_human,GAD,LHGDN 25422913 Detail
0.184 Liver neoplasms Tumorigenesis studies using an established liver tumor cell line confirmed a pos... BeFree,CTD_human,GAD,LHGDN 25526090 Detail
0.184 Liver neoplasms In addition, α-PA up-regulated nuclear p53 and down-regulated cytoplasmic p53 ex... BeFree,CTD_human,GAD,LHGDN 25649747 Detail
0.184 Liver neoplasms Apoptosis of Bel-7402 human hepatoma cells induced by a ruthenium(II) complex co... BeFree,CTD_human,GAD,LHGDN 25651236 Detail
0.120 Liver Neoplasms, Experimental NA CTD_human Detail
<0.001 Lung diseases NA BeFree Detail
0.130 Chronic Obstructive Airway Disease These findings suggest that HBEC apoptosis is increased in COPD, and that this i... BeFree,CTD_human,GAD 24871992 Detail
0.327 Lung Neoplasms A total of 189 lung cancer patients were enrolled to determine nickel levels in ... BeFree,CTD_human,CTD_mouse,GAD,LHGDN 24711049 Detail
0.327 Lung Neoplasms At the molecular level, reduced activation of ERK MAPK, but not Akt, was observe... BeFree,CTD_human,CTD_mouse,GAD,LHGDN 24727895 Detail
0.327 Lung Neoplasms In this work, we found that PNAS-4 expression in lung tumor tissues is significa... BeFree,CTD_human,CTD_mouse,GAD,LHGDN 25918161 Detail
0.009 Lupus Erythematosus, Systemic NA BeFree,GAD,LHGDN Detail
0.014 Lymphatic Metastasis NA GAD Detail
0.163 lymphoma In addition, the protein levels of p53 and alternative reading frame (ARF) were ... BeFree,CTD_mouse,GAD,LHGDN 25175815 Detail
0.163 lymphoma Genomic studies of ALCL-11 showed the TP53 loss and the in vivo subclonal expans... BeFree,CTD_mouse,GAD,LHGDN 25533804 Detail
0.163 lymphoma p53 is a well-known tumor suppressor.However, the regulatory mechanism(s) for p5... BeFree,CTD_mouse,GAD,LHGDN 25544504 Detail
0.163 lymphoma Activation of p53 mediated glycolytic inhibition-oxidative stress-apoptosis path... BeFree,CTD_mouse,GAD,LHGDN 25576833 Detail
0.163 lymphoma Molecular analysis of lymphomas revealed that arginine methylation of p53 select... BeFree,CTD_mouse,GAD,LHGDN 25582697 Detail
0.163 lymphoma We used isogenic lymphoma cell line models to prove p53 dependence of NEAT1 and ... BeFree,CTD_mouse,GAD,LHGDN 25971364 Detail
0.018 Lymphoma, Follicular NA BeFree,GAD,LHGDN Detail
<0.001 Small Cell Lymphoma NA BeFree Detail
0.010 Lymphoproliferative Disorders PUMA protein in p53 regulatory molecule pattern determines the prognosis for pat... BeFree,GAD,LHGDN 24824714 Detail
<0.001 Machado-Joseph disease We report that persistent accumulation of DNA damage/strand breaks and chronic a... BeFree 25590633 Detail
<0.001 Maffucci syndrome NA BeFree Detail
<0.001 malaria NA BeFree Detail
<0.001 Primary malignant neoplasm of liver NA BeFree Detail
0.017 Animal Mammary Neoplasms NA GAD Detail
0.080 Mammary Neoplasms, Experimental NA RGD Detail
<0.001 Mastocytoma NA BeFree Detail
0.022 medulloblastoma Whilst drugs directly targeting SIRT1, were potent to trigger cell death at high... BeFree,GAD 25250818 Detail
0.022 medulloblastoma Combined MYC and P53 defects emerge at medulloblastoma relapse and define rapidl... BeFree,GAD 25533335 Detail
0.022 medulloblastoma WNT activation by lithium abrogates TP53 mutation associated radiation resistanc... BeFree,GAD 25539912 Detail
0.022 medulloblastoma Treatment of Med in Ptch1(+/-) Trp53(-/-) mice with the antiestrogen chemotherap... BeFree,GAD 25885794 Detail
<0.001 megaesophagus NA BeFree Detail
<0.001 multiple endocrine neoplasia type 1 To understand the phenotypic similarities/differences between lung carcinoids an... BeFree 25143124 Detail
<0.001 multiple endocrine neoplasia type 2A NA BeFree Detail
0.005 Meningeal Neoplasms NA GAD Detail
0.029 meningioma NA BeFree,GAD,LHGDN Detail
0.003 Mental Retardation NA BeFree,GAD Detail
0.089 Mesothelioma NA BeFree,CTD_mouse,LHGDN Detail
<0.001 Metabolic Diseases These results uncover a new mechanism of p53 inactivation providing an interesti... BeFree 25260780 Detail
0.007 Metaplasia NA GAD,LHGDN Detail
<0.001 Microphthalmos NA BeFree Detail
<0.001 mitral valve stenosis NA BeFree Detail
0.015 Mixed Salivary Gland Tumor In addition, we tested if Hsp27 protein levels correlated with p53 expression an... BeFree,LHGDN 25230790 Detail
<0.001 Monoclonal Gammopathy of Undetermined Significance NA BeFree Detail
0.007 Monosomy NA BeFree Detail
<0.001 Mouth Diseases NA BeFree Detail
0.341 Mouth Neoplasms NA BeFree,CTD_human,CTD_mouse,GAD,LHGDN,RGD Detail
<0.001 Mucopolysaccharidoses NA BeFree Detail
0.031 multiple myeloma The expression of nine of them is higher in MM plasma cells than in healthy dono... BeFree,GAD,LHGDN 24798859 Detail
0.031 multiple myeloma Moreover, silencing of p53 in two TP53(mutated) cell lines failed to inhibit apo... BeFree,GAD,LHGDN 24927749 Detail
0.031 multiple myeloma This review summarizes different modes of p53 inactivation in myeloma and highli... BeFree,GAD,LHGDN 25028664 Detail
0.031 multiple myeloma ANKHD1 downregulation modulates cell cycle gene expression and upregulates p21 i... BeFree,GAD,LHGDN 25483783 Detail
0.031 multiple myeloma Features of extramedullary disease of multiple myeloma: high frequency of p53 de... BeFree,GAD,LHGDN 25640025 Detail
0.003 multiple sclerosis NA BeFree,GAD Detail
<0.001 muscular atrophy NA BeFree Detail
<0.001 spinal muscular atrophy NA BeFree Detail
<0.001 muscular dystrophy NA BeFree Detail
<0.001 Mycoplasma Infections NA BeFree Detail
<0.001 Mycoses NA BeFree Detail
0.002 mycosis fungoides Additionally, the mutation data identified 2 other potential contributing factor... BeFree 26082451 Detail
0.003 Myelodysplasia NA BeFree Detail
<0.001 myelofibrosis NA BeFree Detail
<0.001 Myelomonocytic leukemia NA BeFree Detail
0.001 Myeloproliferative disease We performed genomic profiling of post-MPN AML samples; these studies demonstrat... BeFree 25516983 Detail
0.081 myocardial infarction NA BeFree,CTD_mouse Detail
0.080 Myocardial Reperfusion Injury NA RGD Detail
<0.001 Myxoma NA BeFree Detail
<0.001 Nasal Polyps NA BeFree Detail
0.012 Nasopharyngeal Neoplasms NA GAD Detail
0.003 Neck Neoplasms NA BeFree Detail
0.012 Neoplasm Invasiveness NA GAD Detail
0.009 Neoplasm Recurrence, Local NA GAD Detail
0.080 Neoplasms, Experimental NA CTD_mouse Detail
<0.001 multiple endocrine neoplasia NA BeFree Detail
0.005 Neoplasms, Radiation-Induced NA GAD Detail
0.122 Neoplastic Syndromes, Hereditary Almost all identified high-penetrance gene mutations in those families fulfill t... BeFree,CLINVAR 25927356 Detail
0.122 Neoplastic Syndromes, Hereditary A significant percentage (5-10%) of pediatric cancers are associated with heredi... BeFree,CLINVAR 26248253 Detail
0.009 nephroblastoma TP53 mutational status is a potential marker for risk stratification in Wilms tu... BeFree 25313908 Detail
0.009 nephroblastoma We show that (i) in the choroid plexus carcinoma, the germline mutation was dete... BeFree 25787918 Detail
0.081 nervous system disorder NA BeFree,CTD_mouse Detail
<0.001 Nervous System Neoplasms Exome DNA sequencing of blood samples from a Li-Fraumeni family with a TP53 germ... BeFree 25041856 Detail
0.002 Neural Tube Defects NA GAD Detail
0.003 neurilemmoma Two family members without a TP53 germline mutation who developed peripheral sch... BeFree,GAD 25041856 Detail
0.003 neurilemmoma Here we investigated p53 regulation and its role in proliferation and survival o... BeFree,GAD 25217104 Detail
0.127 neuroblastoma CFM-1, -4, and -5 inhibited NB cell growth, in vitro, independent of their p53 a... BeFree,CTD_mouse,LHGDN 25033461 Detail
0.127 neuroblastoma Simultaneous Adrenocortical Carcinoma and Neuroblastoma in an Infant With a Nove... BeFree,CTD_mouse,LHGDN 25374282 Detail
0.127 neuroblastoma Of note, less than 2% of neuroblastoma tumors have a TP53 mutation at diagnosis. BeFree,CTD_mouse,LHGDN 25502557 Detail
0.127 neuroblastoma Treatment of wild-type TP53 neuroblastoma cell lines with both GSK2830371 and ei... BeFree,CTD_mouse,LHGDN 25658463 Detail
0.127 neuroblastoma Genome wide expression profiling of p53 regulated miRNAs in neuroblastoma. BeFree,CTD_mouse,LHGDN 25762502 Detail
0.005 neurofibroma NA BeFree,GAD Detail
0.004 neurofibromatosis 1 The most common predisposition syndromes include germline TP53 mutations and con... BeFree 25893277 Detail
0.003 Neurofibromatosis 2 NA BeFree,GAD Detail
0.006 acoustic neuroma NA BeFree,GAD,LHGDN Detail
<0.001 neutropenia NA BeFree Detail
0.002 Nevus NA BeFree Detail
0.003 Melanocytic nevus NA BeFree Detail
0.003 Nodule The whitish nodule corresponded to the sarcomatoid component, and the spindled a... BeFree 25424516 Detail
0.002 obesity Inhibition of endothelial p53 improves metabolic abnormalities related to dietar... BeFree 24857662 Detail
0.002 obesity These results uncover a new mechanism of p53 inactivation providing an interesti... BeFree 25260780 Detail
0.002 obesity Prostaglandin E2 inhibits p53 in human breast adipose stromal cells: a novel mec... BeFree 25634217 Detail
0.002 Occupational Diseases NA GAD Detail
0.002 ocular hypertension NA GAD Detail
<0.001 Odontogenic Cysts NA BeFree Detail
0.021 oligodendroglioma Those tumors that lacked LOH 1p19q showed a high frequency of IDH1 mutations and... BeFree,GAD,LHGDN 24444336 Detail
0.021 oligodendroglioma The mean of Olig2 LI of gliomas with 1p/19q loss ± IDH1/2 mutation, the majority... BeFree,GAD,LHGDN 25085214 Detail
0.021 oligodendroglioma We found that oligoastrocytomas harbored mutations in TP53 (80%, 12/15) and ATRX... BeFree,GAD,LHGDN 25257301 Detail
0.021 oligodendroglioma The TP53 and HIST1H3A genes were the hub nodes in the PPI network of DEGs from G... BeFree,GAD,LHGDN 25351872 Detail
0.021 oligodendroglioma Thus, we analyzed the expression of p-CREB in a series of astrocytomas and oligo... BeFree,GAD,LHGDN 25476123 Detail
0.001 oral submucous fibrosis NA BeFree Detail
0.005 Oropharyngeal Neoplasms NA GAD Detail
0.004 Degenerative polyarthritis NA BeFree,GAD Detail
<0.001 Synovial osteochondromatosis NA BeFree Detail
0.003 Bone necrosis NA LHGDN Detail
0.382 osteosarcoma Overexpression of RASSF5 markedly suppressed cell proliferation and invasion, an... BeFree,CLINVAR,CTD_human,GAD,LHGDN,MGD 25109282 Detail
0.382 osteosarcoma Prognostic value of p53 alterations in human osteosarcoma: a meta analysis. BeFree,CLINVAR,CTD_human,GAD,LHGDN,MGD 25400752 Detail
0.382 osteosarcoma p53-dependent activation of microRNA-34a in response to etoposide-induced DNA da... BeFree,CLINVAR,CTD_human,GAD,LHGDN,MGD 25490093 Detail
0.382 osteosarcoma Inactivation of p53 and/or Rb pathways restrains osteoblasts from cell-cycle exi... BeFree,CLINVAR,CTD_human,GAD,LHGDN,MGD 25853231 Detail
0.382 osteosarcoma Here, we established patient-derived iPSCs from a Li-Fraumeni syndrome (LFS) fam... BeFree,CLINVAR,CTD_human,GAD,LHGDN,MGD 25860607 Detail
0.382 osteosarcoma Germline TP53 variants and susceptibility to osteosarcoma. BeFree,CLINVAR,CTD_human,GAD,LHGDN,MGD 25896519 Detail
0.382 osteosarcoma To identify the genes driving osteosarcoma development and metastasis, we perfor... BeFree,CLINVAR,CTD_human,GAD,LHGDN,MGD 25961939 Detail
0.085 ovarian carcinoma Mutation or loss of p53 differentially modifies TGFβ action in ovarian cancer. BeFree,GAD 24586866 Detail
0.085 ovarian carcinoma In this study, the nuclear expression levels of γ-H2AX and p53 using immunohisto... BeFree,GAD 24681744 Detail
0.085 ovarian carcinoma Selective tumor cell killing by triptolide in p53 wild-type and p53 mutant ovari... BeFree,GAD 24880464 Detail
0.085 ovarian carcinoma Association between a single nucleotide polymorphism in the TP53 region and risk... BeFree,GAD 25060098 Detail
0.085 ovarian carcinoma The observed upregulation of pro-apoptotic genes and apoptosis in cancer cells w... BeFree,GAD 25096914 Detail
0.085 ovarian carcinoma We demonstrated that in a unique population of HGSOC cancer cells with cancer st... BeFree,GAD 25263447 Detail
0.085 ovarian carcinoma Genomic classification of serous ovarian cancer with adjacent borderline differe... BeFree,GAD 25316818 Detail
0.085 ovarian carcinoma TP53 oncomorphic mutations predict resistance to platinum‑ and taxane‑based stan... BeFree,GAD 25385265 Detail
0.085 ovarian carcinoma TP53 remains as the most frequently altered gene in high grade serous ovarian ca... BeFree,GAD 25404506 Detail
0.085 ovarian carcinoma Detection of somatic TP53 mutations in tampons of patients with high-grade serou... BeFree,GAD 25437714 Detail
0.085 ovarian carcinoma Molecular characterization of an intact p53 pathway subtype in high-grade serous... BeFree,GAD 25460179 Detail
0.085 ovarian carcinoma Although the effect of new drugs such as poly(ADP-ribose) polymerase inhibitors ... BeFree,GAD 25473022 Detail
0.085 ovarian carcinoma Co-immunoprecipitation and western blotting showed significantly lower levels of... BeFree,GAD 25510663 Detail
0.085 ovarian carcinoma The present study aimed to clarify the role of PLK1, P53 and P21WAF1 in the prog... BeFree,GAD 25592872 Detail
0.085 ovarian carcinoma CR389, a benzoimidazolyl pyridinone analog, induces cell cycle arrest and apopto... BeFree,GAD 25639717 Detail
0.085 ovarian carcinoma Overall, FBN1, acts at the downstream of Aur A and BRCA2, promotes ovarian cance... BeFree,GAD 25749384 Detail
0.085 ovarian carcinoma First, we observed the upregulation protein level of p53 target genes in cisplat... BeFree,GAD 25820823 Detail
0.085 ovarian carcinoma There is a link between miR-7 expression and TP53 status and tumour grade in ser... BeFree,GAD 25862909 Detail
0.085 ovarian carcinoma TP53 hot spot mutations in ovarian cancer: selective resistance to microtubule s... BeFree,GAD 25958320 Detail
0.085 ovarian carcinoma We propose that this unique ability of APR-246/MQ to bind to cysteines in both m... BeFree,GAD 26086967 Detail
0.085 ovarian carcinoma The study found a high expression of P53 (64%) and MIB1 (72%) and an expression ... BeFree,GAD 26204652 Detail
0.001 Pancreatic Diseases NA BeFree Detail
0.237 Pancreatic Neoplasm Autophagy is critical for pancreatic tumor growth and progression in tumors with... BeFree,CTD_human,CTD_mouse,GAD,LHGDN 24875860 Detail
<0.001 pancreatitis NA BeFree Detail
<0.001 pancytopenia NA BeFree Detail
0.021 papilloma CD24 silencing prevents functional inactivation of p53 by both somatic mutation ... BeFree,LHGDN 25600590 Detail
<0.001 Papillon-Lefevre disease NA BeFree Detail
<0.001 paraganglioma NA BeFree Detail
<0.001 Parathyroid Neoplasms NA BeFree Detail
<0.001 Parotid Neoplasms NA BeFree Detail
0.125 Penile Neoplasms NA CTD_human,GAD Detail
0.003 Peptic Ulcer NA BeFree,GAD Detail
<0.001 pericardial effusion NA BeFree Detail
<0.001 periodontitis NA BeFree Detail
<0.001 peritonitis NA BeFree Detail
0.002 Peutz-Jeghers syndrome NA BeFree Detail
0.005 Pharyngeal Neoplasms NA GAD Detail
0.002 pheochromocytoma NA BeFree Detail
0.002 pituitary adenoma NA BeFree Detail
0.001 Pituitary Diseases NA BeFree Detail
0.004 Pituitary Neoplasms NA BeFree,LHGDN Detail
0.003 Pleural effusion disorder NA BeFree,LHGDN Detail
0.003 pleurisy NA BeFree,LHGDN Detail
<0.001 pneumonia In Wild-type (WT) mice with passive CSE (PCSE), p53 and PAI-1 expression and apo... BeFree 25932922 Detail
<0.001 Rothmund-Thomson syndrome NA BeFree Detail
<0.001 polycythemia vera Moreover, inhibition of p53 in PV erythroblasts resulted in more gamma-H2Ax (γ-H... BeFree 25288776 Detail
0.018 Adenomatous Polyposis Coli NA BeFree,GAD Detail
0.005 polyps NA BeFree Detail
0.005 Postoperative Complications NA GAD Detail
0.116 Precancerous Conditions NA BeFree,CTD_mouse,GAD Detail
<0.001 progeria NA BeFree Detail
<0.001 prolactinoma NA BeFree Detail
0.169 Prostatic Neoplasms Met was amplified in 67% of prostate tumors from Pten p53 prostate conditional n... BeFree,CTD_human,GAD,LHGDN 25381262 Detail
<0.001 Protein Deficiency NA BeFree Detail
<0.001 pseudomyxoma peritonei NA BeFree Detail
<0.001 Pseudotumor NA BeFree Detail
0.125 psoriasis NA BeFree,CTD_human,LHGDN Detail
0.010 pterygium NA BeFree,GAD Detail
0.001 pulmonary fibrosis NA BeFree Detail
<0.001 Radicular Cyst NA BeFree Detail
0.025 Rectal Neoplasms Elevated p57Kip2 induces G1/S phase cell cycle arrest but inhibits cell death in... BeFree,GAD,LHGDN 25195859 Detail
<0.001 kidney failure Proteins encoded by CDK2, TP53, and RELA have been associated with the progressi... BeFree 24997640 Detail
0.080 Reperfusion Injury NA RGD Detail
<0.001 Reticuloendotheliosis, X-linked NA BeFree Detail
<0.001 retinal detachment NA BeFree Detail
<0.001 Retinal Diseases NA BeFree Detail
0.061 retinoblastoma In the current study, genetically engineered mice were generated to determine th... BeFree,LHGDN 24469052 Detail
0.061 retinoblastoma In addition, loss-of-function mutations in p53 (TP53) as well as deleterious mut... BeFree,LHGDN 25593300 Detail
0.061 retinoblastoma Following further examination of cell cycle-related factors, MCM2 knockdown inhi... BeFree,LHGDN 25738322 Detail
0.061 retinoblastoma It is unique among the epithelial carcinomas as two distinct pathways to tumouri... BeFree,LHGDN 26274747 Detail
<0.001 Retroviridae Infections NA BeFree Detail
0.012 rhabdomyosarcoma The purpose of the present study was to investigate the role of sirtuin expressi... BeFree,GAD 25341037 Detail
0.012 rhabdomyosarcoma We also demonstrate that miR-605 overexpression leads to a decrease in cell prol... BeFree,GAD 25683625 Detail
0.006 Kaposi sarcoma Kaposi's sarcoma-associated herpesvirus (KSHV)-related malignancies express wild... BeFree,GAD 24469037 Detail
<0.001 Burn scar NA BeFree Detail
0.004 schistosomiasis NA BeFree,LHGDN Detail
0.151 schizophrenia NA BeFree,CTD_human,GAD,LHGDN Detail
<0.001 localized scleroderma NA BeFree Detail
<0.001 systemic scleroderma NA BeFree Detail
<0.001 Seizures NA BeFree Detail
0.002 seminoma NA BeFree Detail
<0.001 Age-related cataract MicroRNA-125b inhibits lens epithelial cell apoptosis by targeting p53 in age-re... BeFree 25312242 Detail
0.121 Sezary syndrome NA BeFree,CTD_human Detail
0.003 Dermatologic disorders NA BeFree,GAD Detail
0.261 Skin Neoplasms NA BeFree,CTD_human,CTD_mouse,GAD,LHGDN Detail
<0.001 smallpox The detection limits for analyzing the Smallpox and TP53 genes correspond to 0.1... BeFree 25369533 Detail
0.001 Soft Tissue Neoplasms NA BeFree Detail
<0.001 Splenic Neoplasms NA BeFree Detail
<0.001 status epilepticus NA BeFree Detail
<0.001 stereotypic movement disorder NA BeFree Detail
<0.001 Stomach Diseases NA BeFree Detail
0.005 gastric ulcer NA BeFree,GAD Detail
<0.001 post-traumatic stress disorder Three other genes, TP53, EP300 and CALM1 might also contribute to the pathogenes... BeFree 25219830 Detail
0.003 Cerebrovascular accident NA BeFree,LHGDN Detail
0.002 Subarachnoid Hemorrhage NA GAD Detail
0.007 Sunburn NA GAD,LHGDN Detail
0.004 synovial sarcoma The purpose of the present study was to investigate the role of sirtuin expressi... BeFree,LHGDN 25341037 Detail
<0.001 synovitis NA BeFree Detail
<0.001 telangiectasis NA BeFree Detail
0.001 Giant Cell Arteritis NA BeFree Detail
<0.001 tendinitis NA BeFree Detail
0.005 teratoma NA BeFree,LHGDN Detail
0.002 Testicular Neoplasms NA BeFree Detail
0.121 Thrombocythemia, Essential NA BeFree,ORPHANET Detail
0.121 thymoma NA BeFree,CTD_human Detail
0.002 Thyroid Diseases NA GAD Detail
0.153 Thyroid Neoplasm A mutation screening of oncogenes, tumor suppressor gene TP53 and nuclear encode... BeFree,CTD_human,GAD,LHGDN 25880213 Detail
0.003 Thyroid Nodule NA BeFree,GAD Detail
<0.001 thyroiditis NA BeFree Detail
0.002 Tobacco use disorder NA GAD Detail
0.167 Tongue Neoplasms NA CTD_mouse,GAD,LHGDN,RGD Detail
0.003 Trisomy NA BeFree Detail
<0.001 Trophoblastic Neoplasms NA BeFree Detail
0.003 Chagas disease NA BeFree,GAD Detail
0.003 tuberculosis NA BeFree,LHGDN Detail
<0.001 pleural tuberculosis NA BeFree Detail
0.001 tuberous sclerosis NA BeFree Detail
0.024 Tumor Virus Infections NA GAD Detail
0.001 Turner syndrome Genomic profile of a Li-Fraumeni-like syndrome patient with a 45,X/46,XX karyoty... BeFree 25935441 Detail
0.080 Adverse reaction to drug NA CTD_mouse Detail
<0.001 Erythema NA BeFree Detail
0.002 uremia NA GAD Detail
0.123 Genitourinary Neoplasms NA CTD_human,LHGDN Detail
0.120 Urologic Neoplasms NA CTD_human Detail
0.004 Uterine Fibroids NA BeFree Detail
0.002 Uterine Neoplasms NA GAD Detail
0.003 Varicose Ulcer NA LHGDN Detail
0.003 Vascular Diseases NA BeFree,LHGDN Detail
<0.001 viral hepatitis NA BeFree Detail
0.005 Virus Diseases To address the unmet need, we recently developed RapidCaP mice, which endogenous... BeFree 25592467 Detail
0.005 Virus Diseases Evaluation of CTNNB1 and TP53 variability in patients with hepatocellular carcin... BeFree 26341700 Detail
<0.001 vitiligo NA BeFree Detail
<0.001 common wart NA BeFree Detail
0.001 Werner syndrome Erythroblasts negative for WRN immunostaining were only observed in two patients... BeFree 25503078 Detail
0.010 xeroderma pigmentosum NA BeFree,GAD Detail
<0.001 Fibromatosis, Aggressive NA BeFree Detail
<0.001 Hallopeau-Siemens Disease NA BeFree Detail
0.014 Helicobacter Infections NA GAD Detail
0.004 Ichthyosis, X-Linked NA BeFree Detail
0.039 B-Cell Lymphomas TP53 mutations are frequent events in double-hit B-cell lymphomas with MYC and B... BeFree,GAD,LHGDN 24679006 Detail
0.039 B-Cell Lymphomas Reversion of apoptotic resistance of TP53-mutated Burkitt lymphoma B-cells to sp... BeFree,GAD,LHGDN 24787013 Detail
0.039 B-Cell Lymphomas MicroRNA-124 links p53 to the NF-κB pathway in B-cell lymphomas. BeFree,GAD,LHGDN 25915824 Detail
0.039 B-Cell Lymphomas Consequently, miR-200-induced T2D is suppressed by interfering with the signalin... BeFree,GAD,LHGDN 25985365 Detail
0.039 B-Cell Lymphomas Mechanistically, 4-MU led to increased p53 mRNA expression, elevated cytoplasmic... BeFree,GAD,LHGDN 26408682 Detail
0.002 High Grade Lymphoma (neoplasm) NA BeFree Detail
0.001 Lymphoma, Large-Cell, Follicular NA BeFree Detail
<0.001 Low Grade Lymphoma (neoplasm) NA BeFree Detail
<0.001 Precursor cell lymphoblastic lymphoma NA BeFree Detail
0.001 Lymphoma, Small Noncleaved-Cell NA BeFree Detail
0.127 T-Cell Lymphoma NA BeFree,CTD_human,LHGDN Detail
0.125 Lymphoma, T-Cell, Cutaneous These alterations were accompanied by increased forkhead box O3 (FoxO3) in sever... BeFree,CTD_human,LHGDN 24343700 Detail
<0.001 peripheral T-cell lymphoma NA BeFree Detail
0.002 spina bifida NA GAD Detail
<0.001 Lysosomal Storage Diseases NA BeFree Detail
<0.001 motor neuron disease NA BeFree Detail
0.002 severe combined immunodeficiency NA BeFree Detail
0.122 Central Nervous System Neoplasms NA BeFree,CTD_human Detail
0.003 Choroid Plexus Neoplasms NA BeFree,GAD Detail
0.009 Neoplasms, Second Primary NA BeFree,GAD Detail
0.003 Adult-Onset Still Disease NA LHGDN Detail
<0.001 encephalitozoonosis NA BeFree Detail
<0.001 Arthritis, Reactive NA BeFree Detail
<0.001 polymyositis NA BeFree Detail
<0.001 Secondary carcinoma NA BeFree Detail
0.006 acute leukemia Our meta-analysis demonstrates that TP53 codon 72 polymorphism may not be a risk... BeFree 26402821 Detail
0.002 Chronic cholecystitis NA BeFree Detail
<0.001 Chronic gastritis NA BeFree Detail
<0.001 Monocytosis NA BeFree Detail
<0.001 Adenosis of Breast NA BeFree Detail
0.009 benign neoplasm NA BeFree Detail
<0.001 Sicca Syndrome NA BeFree Detail
0.003 Pancreatitis, Chronic NA BeFree Detail
<0.001 Adnexal mass NA BeFree Detail
0.017 Epstein-Barr Virus Infections We found that resistance to spindle poison-induced apoptosis could be reverted i... BeFree,GAD,LHGDN 24787013 Detail
0.017 Epstein-Barr Virus Infections In the presented studies p53 and bcl-2 proteins expression were evaluated in sam... BeFree,GAD,LHGDN 26638529 Detail
0.004 Squamous cell carcinoma of lung In non-small cell lung cancer (NSCLC), both USP7 expression and p53 gene status ... BeFree 25519684 Detail
0.004 Squamous cell carcinoma of lung Correlation between squamous cell carcinoma of the lung and human papillomavirus... BeFree 25544708 Detail
0.001 Gastric adenoma NA BeFree Detail
0.260 Small cell carcinoma of lung The PTEN/PIK3CA pathway was interrogated using an AdenoCre-driven mouse model of... BeFree,CTD_human,LHGDN,ORPHANET 24482365 Detail
0.260 Small cell carcinoma of lung In comparison to the carcinoids, LCNEC/SCLC tumors presented a stronger loss of ... BeFree,CTD_human,LHGDN,ORPHANET 25884169 Detail
0.004 Adenocarcinoma of rectum NA BeFree Detail
0.001 Atrophic condition of skin NA BeFree Detail
0.001 Oral Cavity Carcinoma NA BeFree Detail
<0.001 renal fibrosis NA BeFree Detail
0.006 Cutaneous Melanoma NA BeFree Detail
0.095 Adenocarcinoma of lung (disorder) Mutation of TP53 and alteration of p14(arf) expression in EGFR- and KRAS-mutated... BeFree,CTD_mouse,GAD 24169260 Detail
0.095 Adenocarcinoma of lung (disorder) LATS2 mRNA level was found to be a significant independent predictor for surviva... BeFree,CTD_mouse,GAD 24976335 Detail
0.095 Adenocarcinoma of lung (disorder) Proteomic signatures associated with p53 mutational status in lung adenocarcinom... BeFree,CTD_mouse,GAD 25331784 Detail
0.095 Adenocarcinoma of lung (disorder) PBK/TOPK expression correlates with mutant p53 and affects patients' prognosis a... BeFree,CTD_mouse,GAD 25466965 Detail
<0.001 Complete trisomy 18 syndrome NA BeFree Detail
0.003 low tension glaucoma NA BeFree,GAD Detail
<0.001 Cancer of Lip NA BeFree Detail
0.002 Malignant neoplasm of tongue TP53 Pro72 allele is enriched in oral tongue cancer and frequently mutated in es... BeFree 25436609 Detail
0.002 Malignant neoplasm of tongue The increased expression of pS(21)GSK3α and pS(9)GSK3β not only correlated posit... BeFree 25645517 Detail
0.029 Malignant neoplasm of mouth Phenethyl isothiocyanate induces DNA damage-associated G2/M arrest and subsequen... BeFree,GAD 24952138 Detail
0.029 Malignant neoplasm of mouth The detection limits, established as 3σ, were estimated to be 0.03 and 0.06 fmol... BeFree,GAD 25493424 Detail
0.029 Malignant neoplasm of mouth The expression of total and phosphorylated GSK3α/β as well as cyclin D1 and p53 ... BeFree,GAD 25645517 Detail
0.002 Malignant neoplasm of oropharynx Among these biomarkers, p53 is the strongest prognostic marker in OPC and p53 in... BeFree 25380690 Detail
0.002 Malignant neoplasm of oropharynx The biology of HPV-positive oropharyngeal cancer is distinct; it includes p53 de... BeFree 26563006 Detail
0.002 Malignant neoplasm of nasopharynx NA BeFree Detail
0.001 Malignant neoplasm of anus NA BeFree Detail
0.007 Malignant neoplasm of gallbladder High frequency of TP53 but not K-ras gene mutations in Bolivian patients with ga... BeFree 25041017 Detail
<0.001 Malignant tumor of extrahepatic bile duct NA BeFree Detail
<0.001 Malignant Uterine Corpus Neoplasm NA BeFree Detail
<0.001 Malignant neoplasm of fallopian tube NA BeFree Detail
<0.001 Malignant neoplasm of penis NA BeFree Detail
0.006 Malignant neoplasm of brain Alternative lengthening of telomeres is enriched in, and impacts survival of TP5... BeFree,GAD 25315281 Detail
<0.001 Malignant neoplasm of endocrine gland NA BeFree Detail
0.003 Secondary malignant neoplasm of lung Our study, for the first time, demonstrates that GINS2 is an independent prognos... BeFree 25348432 Detail
0.003 Secondary malignant neoplasm of lung Interestingly, the combined silencing of p53 and Toca-1 led to a partial rescue ... BeFree 25547174 Detail
0.003 Secondary malignant neoplasm of lung Tumor cells expressing high-risk TP53 mutations were more invasive and tumorigen... BeFree 25634208 Detail
<0.001 Secondary malignant neoplasm of bone NA BeFree Detail
<0.001 Stage 0 Breast Carcinoma NA BeFree Detail
<0.001 Carcinoma in situ of bladder NA BeFree Detail
<0.001 Corneal pannus NA BeFree Detail
<0.001 Recurrent pterygium NA BeFree Detail
<0.001 endometriosis of ovary Autophagy is upregulated in ovarian endometriosis: a possible interplay with p53... BeFree 25772769 Detail
<0.001 Cleft palate with cleft lip NA BeFree Detail
<0.001 Infections specific to perinatal period NA BeFree Detail
<0.001 acute intermittent porphyria NA BeFree Detail
0.002 Skin Diseases, Bacterial NA GAD Detail
0.002 Skin Diseases, Viral NA GAD Detail
<0.001 Angelman syndrome NA BeFree Detail
<0.001 Neurofibromatoses NA BeFree Detail
0.003 Cicatrix, Hypertrophic NA BeFree,LHGDN Detail
<0.001 porokeratosis NA BeFree Detail
<0.001 Aortic Aneurysm, Abdominal NA BeFree Detail
0.007 Agenesis of corpus callosum Somatic mutations in ACC-associated genes included TP53 (8/41 tumors, 19.5%) and... BeFree 25490274 Detail
0.007 Agenesis of corpus callosum TP53 mutations are prevalent in children with ACC but decline with age. BeFree 25584008 Detail
0.007 Agenesis of corpus callosum The TP53 mutation detection rate in children presenting with ACC or choroid plex... BeFree 26014290 Detail
0.082 Tumor Progression On the contrary, p53 loss led to increased apoptosis that had to be overcome for... BeFree,GAD 24469052 Detail
0.082 Tumor Progression Altered p53 regulation of miR-148b and p55PIK contributes to tumor progression i... BeFree,GAD 24632606 Detail
0.082 Tumor Progression This study provides the first time evidence that RRM2B is transcriptionally and ... BeFree,GAD 24947616 Detail
0.082 Tumor Progression It is therefore important to elucidate the role of these downstream targets in p... BeFree,GAD 25119697 Detail
0.082 Tumor Progression These findings are relevant to human basal-like tumor progression in vivo, since... BeFree,GAD 25123132 Detail
0.082 Tumor Progression These results uncover a new mechanism of p53 inactivation providing an interesti... BeFree,GAD 25260780 Detail
0.082 Tumor Progression Moreover, by two-dimensional gel electrophoresis and mass spectrometry we discov... BeFree,GAD 25263447 Detail
0.082 Tumor Progression Emerging from the shade of p53 mutants: N-terminally truncated variants of the p... BeFree,GAD 25270260 Detail
0.082 Tumor Progression The p53 and NFκB sequence-specific transcription factors play crucial roles in c... BeFree,GAD 25401416 Detail
0.082 Tumor Progression Many cancers express mutant p53 proteins that have lost wild-type tumor suppress... BeFree,GAD 25417702 Detail
0.082 Tumor Progression These results suggest that stroma-derived p53 plays a pivotal role in epithelial... BeFree,GAD 25512506 Detail
0.082 Tumor Progression However, the presence of p53 mutations in skin premalignant lesions suggests tha... BeFree,GAD 25639555 Detail
0.082 Tumor Progression The 14-3-3ζ-driven contextual changes of Smad partners from p53 to Gli2 may serv... BeFree,GAD 25670079 Detail
0.082 Tumor Progression The p53 family and the hypoxia-inducible factors (HIFs): determinants of cancer ... BeFree,GAD 26032560 Detail
<0.001 Microinvasive tumor NA BeFree Detail
0.001 Adenocarcinoma, Tubular NA BeFree Detail
<0.001 follicular adenoma NA BeFree Detail
<0.001 Carcinoid, Goblet Cell NA BeFree Detail
0.004 Anaplastic carcinoma NA BeFree Detail
0.001 Carcinoma, Spindle-Cell NA BeFree Detail
0.005 Undifferentiated carcinoma NA BeFree Detail
0.001 Dysplastic Nevus NA BeFree Detail
<0.001 subependymal giant cell astrocytoma NA BeFree Detail
0.366 choroid plexus papilloma NA BeFree,CLINVAR,CTD_human,GAD,LHGDN,ORPHANET Detail
<0.001 Liposarcoma, Dedifferentiated NA BeFree Detail
<0.001 Liposarcoma, Pleomorphic NA BeFree Detail
0.005 Germ cell tumor NA BeFree Detail
<0.001 Papilloma, Squamous Cell NA BeFree Detail
<0.001 Papillomatosis NA BeFree Detail
<0.001 Sarcoma, Epithelioid NA BeFree Detail
0.001 thymic carcinoma Massively parallel sequencing identifies recurrent mutations in TP53 in thymic c... BeFree 25299233 Detail
0.001 thymic carcinoma TP53 was the most frequently mutated gene in TETs (n = 13; 17%), especially in T... BeFree 25482724 Detail
<0.001 Lung Diseases, Interstitial NA BeFree Detail
0.002 Neuroectodermal Tumors NA BeFree Detail
0.008 Lichen Planus, Oral NA BeFree,GAD,LHGDN Detail
0.004 Ki-1+ Anaplastic Large Cell Lymphoma Genomic studies of ALCL-11 showed the TP53 loss and the in vivo subclonal expans... BeFree 25533804 Detail
0.003 adenosquamous carcinoma NA BeFree,GAD Detail
<0.001 Mixed Tumor, Mullerian NA BeFree Detail
<0.001 pulmonary blastoma NA BeFree Detail
<0.001 endometrial stromal sarcoma NA BeFree Detail
<0.001 angiomyolipoma NA BeFree Detail
<0.001 Liposarcoma, Myxoid NA BeFree Detail
<0.001 Giant Cell Tumor of Bone NA BeFree Detail
<0.001 Histiocytoma, Benign Fibrous NA BeFree Detail
0.003 Dermatofibrosarcoma NA LHGDN Detail
0.002 Fibroadenoma NA BeFree Detail
<0.001 leiomyomatosis NA BeFree Detail
<0.001 alveolar rhabdomyosarcoma NA BeFree Detail
0.001 Rhabdomyosarcoma, Embryonal NA BeFree Detail
0.004 embryonal carcinoma NA BeFree Detail
0.007 Neuroectodermal Tumor, Primitive NA BeFree,GAD Detail
<0.001 teratocarcinoma NA BeFree Detail
<0.001 adrenal cortical adenoma NA BeFree Detail
0.003 hepatocellular adenoma NA BeFree,GAD Detail
<0.001 Adenomatous Polyps NA BeFree Detail
0.124 Adenocarcinoma, Clear Cell NA BeFree,CTD_human,GAD Detail
0.005 Follicular thyroid carcinoma NA BeFree,GAD Detail
0.002 sebaceous adenocarcinoma UV-independent p53 mutations in sebaceous carcinoma of the eyelid. BeFree 24777261 Detail
0.001 acinar cell carcinoma NA BeFree Detail
0.261 adrenocortical carcinoma NA BeFree,CTD_human,LHGDN,ORPHANET Detail
0.015 Carcinoma, Endometrioid ECCCs had SCA-like features with rare expression of estrogen receptor/progestero... BeFree,GAD,LHGDN 25473756 Detail
<0.001 Carcinoma, Lobular NA BeFree Detail
0.002 Medullary carcinoma NA BeFree Detail
0.002 mucoepidermoid carcinoma NA BeFree Detail
0.001 Carcinoma, Neuroendocrine A missense mutation in TP53 exon 7 (c.734G>C) and strong nuclear immunostaining ... BeFree 24327102 Detail
0.213 cholangiocarcinoma CCA with Ov shows significantly higher incidence of the TP53 gene mutation, wher... BeFree,CTD_human,CTD_mouse,LHGDN 24532422 Detail
0.213 cholangiocarcinoma Interestingly, there is a significant difference in the frequency of mutated gen... BeFree,CTD_human,CTD_mouse,LHGDN 25693006 Detail
0.003 Cystadenocarcinoma, Mucinous NA BeFree,LHGDN Detail
0.003 Cystadenocarcinoma, Papillary NA LHGDN Detail
0.014 Cystadenocarcinoma, Serous The overall mutation profile of this cohort of endometrial CCC appears to be mor... BeFree,GAD 25308272 Detail
<0.001 Klatskin tumor NA BeFree Detail
0.005 Carcinoma, Large Cell In non-small cell lung cancer (NSCLC), both USP7 expression and p53 gene status ... BeFree,LHGDN 25519684 Detail
0.007 verrucous carcinoma Diffuse p16 expression was associated with younger age at presentation (P<0.0001... BeFree,LHGDN 26171917 Detail
0.001 Cystadenoma, Serous NA BeFree Detail
0.002 Basal Cell Neoplasm NA GAD Detail
0.006 ganglioglioma NA BeFree,GAD,LHGDN Detail
<0.001 olfactory neuroblastoma NA BeFree Detail
<0.001 ganglioneuroblastoma NA BeFree Detail
<0.001 central neurocytoma NA BeFree Detail
0.008 Squamous Cell Neoplasms NA BeFree,GAD,LHGDN Detail
0.006 inverted papilloma No variation of p16, p21, PLUNC (palate, lung, and nasal epithelium clone protei... BeFree,LHGDN 25013792 Detail
<0.001 Sex cord-stromal tumor NA BeFree Detail
0.121 gliosarcoma NA BeFree,ORPHANET Detail
0.087 Nerve Sheath Tumors NA BeFree,CTD_mouse,GAD,LHGDN Detail
<0.001 Angiofibroma NA BeFree Detail
<0.001 Strawberry nevus of skin NA BeFree Detail
<0.001 Rhabdoid Tumor NA BeFree Detail
0.006 Neuroendocrine Tumors Genetic alterations in human cancers and murine models indicate that retinoblast... BeFree,LHGDN 24469052 Detail
0.006 Neuroendocrine Tumors The p53 network as therapeutic target in gastroenteropancreatic neuroendocrine n... BeFree,LHGDN 25837868 Detail
<0.001 Nevi and Melanomas NA BeFree Detail
<0.001 childhood brain tumor Interestingly, ALT attenuated the poor outcome conferred by TP53 mutations in sp... BeFree 25315281 Detail
<0.001 childhood rhabdomyosarcoma NA BeFree Detail
<0.001 Adult Acute Myeloblastic Leukemia NA BeFree Detail
<0.001 pediatric acute myeloblastic leukemia NA BeFree Detail
0.002 uveal melanoma NA BeFree Detail
0.020 Lip and oral cavity carcinoma Phenethyl isothiocyanate induces DNA damage-associated G2/M arrest and subsequen... BeFree 24952138 Detail
0.020 Lip and oral cavity carcinoma The detection limits, established as 3σ, were estimated to be 0.03 and 0.06 fmol... BeFree 25493424 Detail
0.020 Lip and oral cavity carcinoma The expression of total and phosphorylated GSK3α/β as well as cyclin D1 and p53 ... BeFree 25645517 Detail
<0.001 childhood soft tissue sarcoma NA BeFree Detail
<0.001 Renal Pelvis and Ureter Urothelial Carcinoma NA BeFree Detail
0.002 Metastatic malignant neoplasm to brain NA BeFree Detail
<0.001 Congenital defects NA BeFree Detail
<0.001 Adult type dermatomyositis NA BeFree Detail
0.002 Comedone NA BeFree Detail
<0.001 Juvenile polyp NA BeFree Detail
<0.001 Lesion of brain NA BeFree Detail
0.001 Premature aging syndrome NA BeFree Detail
<0.001 Fibrosing adenosis NA BeFree Detail
0.002 Malignant neoplasm of female breast Mutational profiling of familial male breast cancers reveals similarities with l... BeFree 25490678 Detail
0.009 gallbladder carcinoma High frequency of TP53 but not K-ras gene mutations in Bolivian patients with ga... BeFree 25041017 Detail
0.009 gallbladder carcinoma All MSI tumors were negative for HER2 amplification, and TP53 and NRAS mutations... BeFree 25680569 Detail
0.157 pancreatic carcinoma Other genetic alterations, including telomere shortening and the inactivation of... BeFree,CLINVAR 24445769 Detail
0.157 pancreatic carcinoma Taken together, our data indicate that PRIMA-1 induces apoptosis in p53 mutant p... BeFree,CLINVAR 24838627 Detail
0.157 pancreatic carcinoma Together, our data support the critical role of autophagy in pancreatic cancer a... BeFree,CLINVAR 24875860 Detail
0.157 pancreatic carcinoma Studies of the molecular pathology of pancreatic cancer have revealed that activ... BeFree,CLINVAR 25152585 Detail
0.157 pancreatic carcinoma pERK, pAKT and p53 as tissue biomarkers in erlotinib-treated patients with advan... BeFree,CLINVAR 25164437 Detail
0.157 pancreatic carcinoma We investigated the prevalence of germline mutations in APC, ATM, BRCA1, BRCA2, ... BeFree,CLINVAR 25479140 Detail
0.157 pancreatic carcinoma Chromosomal rearrangements leading to gene disruption were prevalent, affecting ... BeFree,CLINVAR 25719666 Detail
0.157 pancreatic carcinoma Therapeutic Targeting of the Warburg Effect in Pancreatic Cancer Relies on an Ab... BeFree,CLINVAR 26113084 Detail
0.157 pancreatic carcinoma Here we report a systematic definition of how pancreatic cancer cells harboring ... BeFree,CLINVAR 26141863 Detail
0.157 pancreatic carcinoma Enhanced phosphorylation of p53 by microRNA-26a leading to growth inhibition of ... BeFree,CLINVAR 26189069 Detail
0.002 Substance-Related Disorders NA GAD Detail
<0.001 adnexal lesion NA BeFree Detail
<0.001 Carcinoma of extrahepatic bile duct NA BeFree Detail
<0.001 Breast Phyllodes Tumor NA BeFree Detail
0.001 Carcinoma of male breast NA BeFree Detail
<0.001 Intraductal papilloma of breast NA BeFree Detail
0.002 fallopian tube carcinoma NA BeFree Detail
<0.001 gallbladder adenoma NA BeFree Detail
0.008 Gastrointestinal Stromal Tumors NA BeFree,GAD,LHGDN Detail
<0.001 Polyp of larynx NA BeFree Detail
<0.001 Muscular Dystrophy, Facioscapulohumeral NA BeFree Detail
0.002 Cancer of Nasopharynx NA BeFree Detail
<0.001 Hereditary pancreatitis NA BeFree Detail
0.001 Squamous cell carcinoma of penis Epigenetic silencing of miR-218 is a common feature in HR-HPV(+) PSCCs and in HR... BeFree 25455689 Detail
<0.001 Renal Pelvis Urothelial Carcinoma NA BeFree Detail
0.002 Medullary carcinoma of thyroid In the current study, genetically engineered mice were generated to determine th... BeFree 24469052 Detail
0.006 Papillary thyroid carcinoma By simultaneously activating Kras and deleting p53 (Trp53) in thyroid follicular... BeFree 25012986 Detail
0.006 Papillary thyroid carcinoma In immunohistochemical studies, DSVPTC showed different expression patterns of e... BeFree 25577570 Detail
0.006 Papillary thyroid carcinoma Pri-Mir-34b/C and Tp-53 Polymorphisms are Associated With The Susceptibility of ... BeFree 26402809 Detail
<0.001 Interstitial fibrosis NA BeFree Detail
<0.001 Angiomyolipoma of kidney NA BeFree Detail
<0.001 islet cell tumor NA BeFree Detail
0.160 Malignant neoplasm of lung Ectopic expression of miR-506 inhibits NF-κB p65 expression, induces ROS accumul... BeFree,GAD 24469051 Detail
0.160 Malignant neoplasm of lung Nickel accumulation in lung tissues is associated with increased risk of p53 mut... BeFree,GAD 24711049 Detail
0.160 Malignant neoplasm of lung Rapamycin prevents strong phosphorylation of p53 on serine 46 and attenuates act... BeFree,GAD 24915467 Detail
0.160 Malignant neoplasm of lung TP53 mutations and lung cancer: not all mutations are created equal. BeFree,GAD 24916693 Detail
0.160 Malignant neoplasm of lung Caveolin-1 regulates lung cancer stem-like cell induction and p53 inactivation i... BeFree,GAD 24939878 Detail
0.160 Malignant neoplasm of lung AP-2α downregulation by cigarette smoke condensate is counteracted by p53 in hum... BeFree,GAD 25050743 Detail
0.160 Malignant neoplasm of lung β-Elemene against human lung cancer via up-regulation of P53 protein expression ... BeFree,GAD 25204604 Detail
0.160 Malignant neoplasm of lung We evaluated 23 single nucleotide polymorphisms (SNPs) in the five nicotinic rec... BeFree,GAD 25233467 Detail
0.160 Malignant neoplasm of lung Evaluation of the mutagenicity of anti-B[a]P-diol epoxide with B[a]P-7,8-dione o... BeFree,GAD 25279998 Detail
0.160 Malignant neoplasm of lung Loss of p53 function may result in upregulation of 14-3-3γ in lung cancers. BeFree,GAD 25384678 Detail
0.160 Malignant neoplasm of lung In addition, we used lung cancer cell lines with different p53 gene background (... BeFree,GAD 25398693 Detail
0.160 Malignant neoplasm of lung Finally, we provide an analysis of discerning epidemiological data obtained from... BeFree,GAD 25433984 Detail
0.160 Malignant neoplasm of lung SOX30, a novel epigenetic silenced tumor suppressor, promotes tumor cell apoptos... BeFree,GAD 25435374 Detail
0.160 Malignant neoplasm of lung Moreover, co-treatment of MML and p53 inhibitor would be more effective in human... BeFree,GAD 25490748 Detail
0.160 Malignant neoplasm of lung Thus, we conclude that p53 deficiency and KRAS mutation activate the NF-κB signa... BeFree,GAD 25499080 Detail
0.160 Malignant neoplasm of lung Our finding supports that mir-660 acts as a tumor suppressor miRNA and we sugges... BeFree,GAD 25501825 Detail
0.160 Malignant neoplasm of lung These results suggest that stroma-derived p53 plays a pivotal role in epithelial... BeFree,GAD 25512506 Detail
0.160 Malignant neoplasm of lung Association of a p53 codon 72 gene polymorphism with environmental factors and r... BeFree,GAD 25605155 Detail
0.160 Malignant neoplasm of lung We identified mutations in both tumors, including KEAP1 (commonly mutated in lun... BeFree,GAD 25850996 Detail
0.160 Malignant neoplasm of lung Treatment of cells with curcumin induced both p53 and the related protein p73 in... BeFree,GAD 25910231 Detail
0.160 Malignant neoplasm of lung TP53 Codon 72 Polymorphisms and Lung Cancer Risk in the Bangladeshi Population. BeFree,GAD 25921167 Detail
0.160 Malignant neoplasm of lung Furthermore, using data generated by The Cancer Genome Atlas consortium, we demo... BeFree,GAD 26063617 Detail
0.160 Malignant neoplasm of lung These results demonstrate that p53 is able to respond to exposure of arsenic or ... BeFree,GAD 26091798 Detail
0.160 Malignant neoplasm of lung However, p53-targeted therapies have limited application in lung cancer, since p... BeFree,GAD 26093302 Detail
0.160 Malignant neoplasm of lung This RNA aptamer (p53R175H-APT) has a significantly stronger affinity to p53R175... BeFree,GAD 26216949 Detail
0.001 Mandibulofacial Dysostosis NA BeFree Detail
<0.001 Parkinsonian Disorders NA BeFree Detail
<0.001 Drug usage NA BeFree Detail
<0.001 Residual Cancer NA BeFree Detail
0.002 Neoplasm, Residual With regards to overall survival, factors predictive of an unfavorable outcome w... BeFree 24700492 Detail
0.002 Isochromosomes NA BeFree Detail
0.009 Mucosa-Associated Lymphoid Tissue Lymphoma NA BeFree,GAD Detail
0.003 Disease Progression NA LHGDN Detail
<0.001 Malignant neoplasm of male breast NA BeFree Detail
<0.001 Proliferative vitreoretinopathy NA BeFree Detail
<0.001 mixed gliomas NA BeFree Detail
0.001 Malignant Meningioma NA BeFree Detail
0.002 Multiple tumors The inability of mice to develop HCC when autophagy was impaired was associated ... BeFree 25526090 Detail
<0.001 Carcinoma of ampulla of Vater NA BeFree Detail
0.127 Carcinoma, Small Cell The pathogenesis of prostatic SCNC involves a p53 and Aurora Kinase A signaling ... BeFree,CTD_human,LHGDN 25512615 Detail
0.001 parathyroid adenoma NA BeFree Detail
<0.001 Vagina Carcinoma NA BeFree Detail
0.004 Acute respiratory failure NA BeFree Detail
<0.001 Chronic heart failure NA BeFree Detail
<0.001 Cardiac dilatation NA BeFree Detail
0.002 Miller Dieker syndrome TP53 overexpression is a predictor of poor outcome in patients with MDS-F. BeFree 26123119 Detail
0.001 Turcot syndrome (disorder) NA BeFree Detail
<0.001 CHARGE syndrome NA BeFree Detail
<0.001 Chromosome 20, trisomy NA BeFree Detail
<0.001 dyskeratosis congenita Together, the results of this study support PARN as a DC-associated gene and sug... BeFree 25893598 Detail
<0.001 Congenital absence of liver NA BeFree Detail
0.001 Exencephaly NA BeFree Detail
<0.001 Congenital ear anomaly NOS (disorder) NA BeFree Detail
<0.001 Erythroplakia of mouth NA BeFree Detail
<0.001 Actinic cheilitis NA BeFree Detail
<0.001 Gastric dysplasia NA BeFree Detail
<0.001 Intestinal metaplasia of gastric mucosa NA BeFree Detail
<0.001 Chronic colitis NA BeFree Detail
<0.001 hepatobiliary disease NA BeFree Detail
<0.001 Xeroderma Pigmentosum, Complementation Group D NA BeFree Detail
<0.001 Simple renal cyst NA BeFree Detail
<0.001 Endometrioma Moreover, a significant decrease of p53 protein and a significant increase of he... BeFree 25772769 Detail
<0.001 Germinal inclusion cyst of ovary NA BeFree Detail
<0.001 Spastic syndrome NA BeFree Detail
<0.001 Shwachman syndrome NA BeFree Detail
<0.001 Chronic idiopathic thrombocytopenic purpura NA BeFree Detail
<0.001 Coinfection NA BeFree Detail
<0.001 Canarypox (disorder) NA BeFree Detail
<0.001 Verruca plana NA BeFree Detail
<0.001 Chronic viral hepatitis NA BeFree Detail
0.002 Stage III Colon Cancer NA BeFree Detail
<0.001 Malignant neoplasm of colon stage IV Functional TP53 mutations have no impact on response to cytotoxic agents in meta... BeFree 25609485 Detail
<0.001 Breast cancer stage II NA BeFree Detail
<0.001 Stage III Breast Cancer AJCC v6 NA BeFree Detail
0.002 Carcinoma breast stage IV NA BeFree Detail
<0.001 Breast cancer recurrent NA BeFree Detail
0.002 Non-small cell lung cancer stage I NA BeFree Detail
<0.001 Non-small cell lung cancer stage III NA BeFree Detail
<0.001 Medulloblastoma, Childhood NA BeFree Detail
<0.001 Osteosarcoma localised NA BeFree Detail
<0.001 Metastatic osteosarcoma NA BeFree Detail
<0.001 Non-small cell lung cancer recurrent NA BeFree Detail
<0.001 recurrent childhood acute lymphoblastic leukemia NA BeFree Detail
0.002 inflammatory breast carcinoma Furthermore a minimal IBC-related predictive set of 4 miRNAs associated with the... BeFree 25471792 Detail
<0.001 Metastatic Renal Cell Cancer NA BeFree Detail
<0.001 Ovarian epithelial cancer stage III NA BeFree Detail
0.001 Ovarian epithelial cancer recurrent NA BeFree Detail
<0.001 Neuroblastoma recurrent NA BeFree Detail
0.006 gastric adenocarcinoma The obtained results allow the conclusion, that H. pylori (cagA+)-associated dev... BeFree 26638529 Detail
0.001 Malignant Childhood Neoplasm A significant percentage (5-10%) of pediatric cancers are associated with heredi... BeFree 26248253 Detail
<0.001 Small cell lung cancer extensive stage NA BeFree Detail
0.002 Chronic lymphocytic leukaemia refractory We investigated the safety and activity of ibrutinib in previously untreated and... BeFree 25555420 Detail
<0.001 Endometrial neoplasm malignant stage I NA BeFree Detail
<0.001 Recurrent Endometrial Cancer NA BeFree Detail
<0.001 Prostate cancer recurrent NA BeFree Detail
<0.001 Medulloblastoma, Adult NA BeFree Detail
0.002 Metastatic melanoma NA BeFree Detail
<0.001 Non-small cell lung cancer metastatic NA BeFree Detail
0.033 Cancer of Head and Neck Phase I dendritic cell p53 peptide vaccine for head and neck cancer. BeFree,GAD 24583792 Detail
0.033 Cancer of Head and Neck TP53 is the most commonly mutated gene in head and neck cancer (HNSCC), with mut... BeFree,GAD 25119136 Detail
0.033 Cancer of Head and Neck Anomalous altered expressions of downstream gene-targets in TP53-miRNA pathways ... BeFree,GAD 25186767 Detail
0.033 Cancer of Head and Neck Wee-1 kinase inhibition overcomes cisplatin resistance associated with high-risk... BeFree,GAD 25504633 Detail
0.033 Cancer of Head and Neck Salivary adenoid cystic carcinoma (SACC) is a malignant tumor that is characteri... BeFree,GAD 25625376 Detail
0.033 Cancer of Head and Neck Evolutionary Action Score of TP53 Identifies High-Risk Mutations Associated with... BeFree,GAD 25634208 Detail
0.033 Cancer of Head and Neck Evolutionary Action Score of TP53 Coding Variants Is Predictive of Platinum Resp... BeFree,GAD 25691460 Detail
0.033 Cancer of Head and Neck The role of HPV RNA transcription, immune response-related gene expression and d... BeFree,GAD 26095926 Detail
0.005 Liver and Intrahepatic Biliary Tract Carcinoma One such example is hepatitis virus-induced liver cancer whereby p53 is inactiva... BeFree 25404244 Detail
0.005 Liver and Intrahepatic Biliary Tract Carcinoma NUMB phosphorylation destabilizes p53 and promotes self-renewal of tumor-initiat... BeFree 26174965 Detail
<0.001 Philadelphia chromosome positive chronic myelogenous leukemia NA BeFree Detail
<0.001 Lobular carcinoma in situ of breast NA BeFree Detail
0.001 Invasive lobular breast carcinoma NA BeFree Detail
<0.001 T-cell childhood acute lymphoblastic leukemia NA BeFree Detail
<0.001 Fibroblastic osteosarcoma NA BeFree Detail
<0.001 Small cell osteosarcoma NA BeFree Detail
0.230 Squamous cell carcinoma of esophagus Association between SNPs in P53 binding regions and risk of esophageal squamous ... BeFree,CTD_human,CTD_mouse,GAD 24474449 Detail
0.230 Squamous cell carcinoma of esophagus LINE-1 hypomethylation of ESCC was significantly associated with lymph node meta... BeFree,CTD_human,CTD_mouse,GAD 24898425 Detail
0.230 Squamous cell carcinoma of esophagus Combined effects of leukocyte telomere length, p53 polymorphism and human papill... BeFree,CTD_human,CTD_mouse,GAD 25153662 Detail
0.230 Squamous cell carcinoma of esophagus Esophageal cells overexpressing epidermal growth factor receptor (EGFR) and TP53... BeFree,CTD_human,CTD_mouse,GAD 25795715 Detail
0.441 Li-Fraumeni syndrome 1 These findings identify an important subgroup of young patients with cancer who ... UNIPROT 1565144 Detail
0.441 Li-Fraumeni syndrome 1 Database of mutations in the p53 and APC tumor suppressor genes designed to faci... UNIPROT 8829653 Detail
0.132 Adenocarcinoma Of Esophagus Combining the techniques detected TP53 abnormalities in 100% of patients with LG... BeFree,CTD_human,GAD 25284618 Detail
0.132 Adenocarcinoma Of Esophagus Barrett's esophagus is thought to progress to esophageal adenocarcinoma (EAC) th... BeFree,CTD_human,GAD 26192918 Detail
0.441 Li-Fraumeni syndrome 1 p53 mutations in human cancers. UNIPROT 1905840 Detail
0.002 anal carcinoma NA BeFree Detail
<0.001 gallbladder adenocarcinoma Expression of cell cycle-related proteins, p16, p53 and p63 as important prognos... BeFree 24178677 Detail
0.004 cervical squamous cell carcinoma To investigate protein expression and mutations in phosphatase and tensin homolo... BeFree 25003471 Detail
0.003 cervical adenocarcinoma NA BeFree Detail
0.012 Transitional cell carcinoma of bladder NA BeFree Detail
<0.001 bladder adenocarcinoma The expression patterns of p53 and p16 and an analysis of a possible role of HPV... BeFree 24752337 Detail
0.001 Conventional (Clear Cell) Renal Cell Carcinoma Ubiquitin E3 ligase UHRF1 regulates p53 ubiquitination and p53-dependent cell ap... BeFree 26102039 Detail
<0.001 endometrial clear cell adenocarcinoma NA BeFree Detail
0.003 extraosseous Ewings sarcoma-primitive neuroepithelial tumor NA BeFree Detail
<0.001 Carcinoid tumor of lung NA BeFree Detail
0.015 Solid tumour These studies showed that TP53 and PI3KCA are the two most mutated genes in all ... BeFree 24833724 Detail
0.015 Solid tumour The human cervical cancer oncogene (HCCR) has been shown to be over-expressed in... BeFree 25034723 Detail
<0.001 Acute Undifferentiated Leukemia Genetic deletion of the telomerase subunit Terc in a retroviral mouse AML model ... BeFree 25479751 Detail
0.001 stage, non-small cell lung cancer The influence of TP53 mutations on the prognosis of patients with early stage no... BeFree 24038464 Detail
0.001 stage, non-small cell lung cancer TP53 mutations in early-stage non-small cell lung cancer (NSCLC) may be associat... BeFree 24696321 Detail
0.001 stage, non-small cell lung cancer Prognostic value of ERCC1, ERCC2, XRCC1, and TP53 single nucleotide polymorphism... BeFree 25596702 Detail
<0.001 stage, ovarian epithelial cancer NA BeFree Detail
<0.001 stage, endometrial cancer NA BeFree Detail
<0.001 stage, prostate cancer NA BeFree Detail
<0.001 Verrucous carcinoma of oral cavity Exome sequencing showed that OVC samples lacked mutations in genes commonly asso... BeFree 26014678 Detail
0.002 Squamous cell carcinoma of oropharynx NA BeFree Detail
0.001 Squamous cell carcinoma of the hypopharynx NA BeFree Detail
0.006 laryngeal squamous cell carcinoma NA BeFree,GAD Detail
<0.001 secondary acute myeloid leukemia We show that (i) in the choroid plexus carcinoma, the germline mutation was dete... BeFree 25787918 Detail
<0.001 de novo myelodysplastic syndromes TP53 overexpression is an independent adverse prognostic factor in de novo myelo... BeFree 26123119 Detail
<0.001 high-grade childhood cerebral astrocytoma NA BeFree Detail
<0.001 uterine carcinosarcoma NA BeFree Detail
<0.001 Leiomyosarcoma of uterus NA BeFree Detail
<0.001 Sarcoma of ovary NA BeFree Detail
0.001 juvenile pilocytic astrocytoma NA BeFree Detail
0.004 diffuse astrocytoma NA BeFree Detail
<0.001 anaplastic ependymoma NA BeFree Detail
0.001 mixed oligodendroglioma-astrocytoma In all but one OA the combination of nuclear p53 accumulation and ATRX loss was ... BeFree 25143301 Detail
0.001 mixed oligodendroglioma-astrocytoma We found that oligoastrocytomas harbored mutations in TP53 (80%, 12/15) and ATRX... BeFree 25257301 Detail
0.003 Squamous cell carcinoma of vulva As most studies have focused on HPV infection and TP53 mutations, we suggest tha... BeFree 25448458 Detail
0.003 bilateral breast cancer NA BeFree Detail
0.009 Adenocarcinoma of pancreas TP53 mutation is a common event in many cancers, including pancreatic adenocarci... BeFree,GAD 24838627 Detail
<0.001 benign meningioma NA BeFree Detail
<0.001 Condition, Preneoplastic NA BeFree Detail
0.003 interstitial cystitis NA BeFree,LHGDN Detail
<0.001 Myomatous neoplasm NA BeFree Detail
0.005 Prostatic Intraepithelial Neoplasias NA BeFree,GAD Detail
<0.001 Condyloma NA BeFree Detail
0.213 cervix carcinoma Positive staining for p53 was observed in 15 (24.59%) cases of cervical intraepi... BeFree,CLINVAR,GAD 25151759 Detail
0.213 cervix carcinoma Association of a miR-502-binding site single nucleotide polymorphism in the 3'-u... BeFree,CLINVAR,GAD 25169478 Detail
0.213 cervix carcinoma Several factors may contribute to cervical cancer (CC) development, including ge... BeFree,CLINVAR,GAD 25181402 Detail
0.213 cervix carcinoma Msi1 promotes tumor growth and cell proliferation by targeting cell cycle checkp... BeFree,CLINVAR,GAD 25362645 Detail
0.213 cervix carcinoma Expression of the p53 target Wig-1 is associated with HPV status and patient sur... BeFree,CLINVAR,GAD 25379706 Detail
0.213 cervix carcinoma Berberine alters epigenetic modifications, disrupts microtubule network, and mod... BeFree,CLINVAR,GAD 25448308 Detail
0.213 cervix carcinoma The preliminary study of p53 codon 72 polymorphism and risk of cervical carcinom... BeFree,CLINVAR,GAD 25502079 Detail
0.213 cervix carcinoma Overexpression of Nm23H1 but not H2 also inhibited tumorigenesis by human cervic... BeFree,CLINVAR,GAD 25748386 Detail
0.213 cervix carcinoma The mechanism and inhibitory effect of recombinant human P53 adenovirus injectio... BeFree,CLINVAR,GAD 25855930 Detail
0.122 Arsenic Poisoning NA CTD_human,GAD Detail
<0.001 Anastomosis NA BeFree Detail
0.006 Restenosis NA BeFree,GAD Detail
0.001 Superficial ulcer NA BeFree Detail
0.003 Tumor necrosis NA BeFree Detail
0.002 Triploidy syndrome NA BeFree Detail
0.002 Squamous intraepithelial lesion NA BeFree Detail
0.001 High-Grade Squamous Intraepithelial Lesions NA BeFree Detail
<0.001 Focal Nodular Hyperplasia NA BeFree Detail
0.003 Hyperplastic Polyp Formalin Fixed Paraffin Embedded tissue were studied for miRNA expression, KRAS,... BeFree 25496852 Detail
<0.001 Lymphoid hyperplasia NA BeFree Detail
<0.001 Adenosis NA BeFree Detail
<0.001 Hamartomatous polyp NA BeFree Detail
<0.001 Bowenoid papulosis NA BeFree Detail
<0.001 Multiple polyps NA BeFree Detail
<0.001 inflammatory myofibroblastic tumor NA BeFree Detail
<0.001 pleomorphic carcinoma NA BeFree Detail
<0.001 Papillary squamous cell carcinoma NA BeFree Detail
<0.001 Intraepithelial Squamous Cell Carcinoma NA BeFree Detail
<0.001 Squamous cell carcinoma, metastatic NA BeFree Detail
<0.001 Squamous cell carcinoma, keratinizing NA BeFree Detail
<0.001 Squamous cell carcinoma, microinvasive NA BeFree Detail
0.001 Lymphoepithelial carcinoma NA BeFree Detail
<0.001 Transitional cell carcinoma in situ NA BeFree Detail
<0.001 Papillary transitional cell carcinoma NA BeFree Detail
<0.001 adenocarcinoma in situ NA BeFree Detail
0.002 Adenocarcinoma, intestinal type NA BeFree Detail
<0.001 Multiple adenomatous polyps NA BeFree Detail
0.001 Carcinoid tumor no ICD-O subtype Although the status of RB1 and P53 between carcinoids and HGNETs were apparently... BeFree 25143124 Detail
<0.001 Skin appendage adenoma NA BeFree Detail
<0.001 Sweat gland adenocarcinoma NA BeFree Detail
0.002 Papillary serous cystadenocarcinoma NA BeFree Detail
<0.001 Mucinous cystic tumor of borderline malignancy TP53 mutation occurred more frequently in carcinomas than borderline tumors (56.... BeFree 25986173 Detail
<0.001 Non-infiltrating lobular carcinoma NA BeFree Detail
<0.001 Leydig cell tumor, benign NA BeFree Detail
<0.001 Superficial spreading malignant melanoma of skin NA BeFree Detail
0.003 malignant fibrous histiocytoma NA BeFree Detail
<0.001 Round cell liposarcoma NA BeFree Detail
<0.001 Clear cell sarcoma of kidney NA BeFree Detail
0.001 Teratoma, Malignant NA BeFree Detail
<0.001 Hydatidiform Mole, Partial NA BeFree Detail
<0.001 Malignant Giant Cell Tumor of Bone NA BeFree Detail
0.001 gliomatosis cerebri NA BeFree Detail
0.016 anaplastic astrocytoma NA BeFree,GAD Detail
0.001 gemistocytic astrocytoma NA BeFree Detail
0.001 fibrillary astrocytoma NA BeFree Detail
0.003 pilocytic astrocytoma NA BeFree Detail
<0.001 pleomorphic xanthoastrocytoma NA BeFree Detail
0.121 giant cell glioblastoma NA BeFree,ORPHANET Detail
0.004 anaplastic oligodendroglioma Those tumors that lacked LOH 1p19q showed a high frequency of IDH1 mutations and... BeFree 24444336 Detail
0.004 anaplastic oligodendroglioma The mean of Olig2 LI of gliomas with 1p/19q loss ± IDH1/2 mutation, the majority... BeFree 25085214 Detail
0.004 anaplastic oligodendroglioma We found that oligoastrocytomas harbored mutations in TP53 (80%, 12/15) and ATRX... BeFree 25257301 Detail
0.004 anaplastic oligodendroglioma The TP53 and HIST1H3A genes were the hub nodes in the PPI network of DEGs from G... BeFree 25351872 Detail
0.004 anaplastic oligodendroglioma Thus, we analyzed the expression of p-CREB in a series of astrocytomas and oligo... BeFree 25476123 Detail
0.004 anaplastic oligodendroglioma We find evidence of regional mutational heterogeneity in multiple tumors, includ... BeFree 25608559 Detail
<0.001 Malignant peripheral nerve sheath tumor with rhabdomyoblastic differentiation NA BeFree Detail
0.012 Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse Progressive leukemic non-nodal mantle cell lymphoma associated with deletions of... BeFree,LHGDN 24852242 Detail
0.012 Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse High-dose cytarabine does not overcome the adverse prognostic value of CDKN2A an... BeFree,LHGDN 26022239 Detail
<0.001 mast cell neoplasm NA BeFree Detail
0.002 Adenocarcinoma of colon NA BeFree Detail
<0.001 Chronic hyperplastic candidiasis NA BeFree Detail
0.001 Jaw Keratocyst NA BeFree Detail
<0.001 Gastric Hamartoma NA BeFree Detail
<0.001 Ulcerative jejunitis NA BeFree Detail
<0.001 Chronic liver disease NA BeFree Detail
<0.001 Epithelial tumor of ovary NA BeFree Detail
<0.001 Adrenocortical hyperplasia NA BeFree Detail
0.008 Human papilloma virus infection Combined effects of leukocyte telomere length, p53 polymorphism and human papill... BeFree 25153662 Detail
0.008 Human papilloma virus infection Correlation between squamous cell carcinoma of the lung and human papillomavirus... BeFree 25544708 Detail
<0.001 Penile warts NA BeFree Detail
<0.001 Macroprolactinoma NA BeFree Detail
0.001 Carcinoma ex pleomorphic adenoma NA BeFree Detail
<0.001 Carcinoma of parotid gland NA BeFree Detail
0.011 Malignant neoplasm of liver One such example is hepatitis virus-induced liver cancer whereby p53 is inactiva... BeFree,GAD 25404244 Detail
0.011 Malignant neoplasm of liver NUMB phosphorylation destabilizes p53 and promotes self-renewal of tumor-initiat... BeFree,GAD 26174965 Detail
0.003 intrahepatic cholangiocarcinoma NA BeFree Detail
0.001 Angiosarcoma of liver NA BeFree Detail
<0.001 Large cell carcinoma of lung NA BeFree Detail
0.003 malignant mesothelioma NA BeFree Detail
<0.001 Solitary keratoacanthoma NA BeFree Detail
<0.001 Pilar tumor NA BeFree Detail
0.001 Atypical fibroxanthoma of skin NA BeFree Detail
0.007 Breast Cancer, Familial However, only about 20% of familial breast cancer is attributed to mutations in ... BeFree 25736863 Detail
0.001 Endometrioid carcinoma ovary NA BeFree Detail
0.004 Vulval intraepithelial neoplasia Diffuse p16 expression was associated with younger age at presentation (P<0.0001... BeFree 26171917 Detail
<0.001 pituitary carcinoma NA BeFree Detail
<0.001 Squamous cell carcinoma of conjunctiva NA BeFree Detail
<0.001 Malignant melanoma of choroid NA BeFree Detail
0.002 Malignant neoplasm of adrenal cortex NA BeFree Detail
<0.001 Multiple malignancy NA BeFree Detail
<0.001 intestinal cancer NA BeFree Detail
0.039 Malignant neoplasm of pancreas Other genetic alterations, including telomere shortening and the inactivation of... BeFree,GAD 24445769 Detail
0.039 Malignant neoplasm of pancreas Taken together, our data indicate that PRIMA-1 induces apoptosis in p53 mutant p... BeFree,GAD 24838627 Detail
0.039 Malignant neoplasm of pancreas Together, our data support the critical role of autophagy in pancreatic cancer a... BeFree,GAD 24875860 Detail
0.039 Malignant neoplasm of pancreas Studies of the molecular pathology of pancreatic cancer have revealed that activ... BeFree,GAD 25152585 Detail
0.039 Malignant neoplasm of pancreas pERK, pAKT and p53 as tissue biomarkers in erlotinib-treated patients with advan... BeFree,GAD 25164437 Detail
0.039 Malignant neoplasm of pancreas We investigated the prevalence of germline mutations in APC, ATM, BRCA1, BRCA2, ... BeFree,GAD 25479140 Detail
0.039 Malignant neoplasm of pancreas Chromosomal rearrangements leading to gene disruption were prevalent, affecting ... BeFree,GAD 25719666 Detail
0.039 Malignant neoplasm of pancreas Therapeutic Targeting of the Warburg Effect in Pancreatic Cancer Relies on an Ab... BeFree,GAD 26113084 Detail
0.039 Malignant neoplasm of pancreas Here we report a systematic definition of how pancreatic cancer cells harboring ... BeFree,GAD 26141863 Detail
0.039 Malignant neoplasm of pancreas Enhanced phosphorylation of p53 by microRNA-26a leading to growth inhibition of ... BeFree,GAD 26189069 Detail
0.002 Disseminated Malignant Neoplasm NA BeFree Detail
<0.001 Secondary malignant neoplasm of pancreas NA BeFree Detail
<0.001 Secondary malignant neoplasm of female breast NA BeFree Detail
<0.001 Anal intraepithelial neoplasia NA BeFree Detail
<0.001 Carcinoma in situ of fallopian tube NA BeFree Detail
<0.001 Polyp of duodenum NA BeFree Detail
<0.001 skin papilloma Conversely, DEK loss results in cell death in HPV-positive cervical cancer cells... BeFree 24608431 Detail
<0.001 Malignant neoplasm of central nervous system NA BeFree Detail
0.001 Cervical intraepithelial neoplasia grade 1 NA BeFree Detail
0.001 Cervical intraepithelial neoplasia grade 2 NA BeFree Detail
0.002 Early gastric cancer NA BeFree Detail
0.001 gastric lymphoma NA BeFree Detail
<0.001 Carcinoma of anal margin NA BeFree Detail
<0.001 Vulval intraepithelial neoplasia grade 3 NA BeFree Detail
0.002 Squamous cell carcinoma of tongue Cantharidin inhibits cell proliferation and promotes apoptosis in tongue squamou... BeFree 25962755 Detail
<0.001 Atypical endometrial hyperplasia NA BeFree Detail
0.002 Richter's syndrome Somatic mutations contributing to the development of RS include TP53 disruption,... BeFree 25218362 Detail
0.002 Splenic Marginal Zone B-Cell Lymphoma NA BeFree Detail
<0.001 Hairy cell leukemia variant NA BeFree Detail
0.001 juvenile myelomonocytic leukemia NA BeFree Detail
<0.001 Trichoepithelioma NA BeFree Detail
<0.001 Sarcoma of breast NA BeFree Detail
0.003 Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site NA BeFree Detail
<0.001 Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site NA BeFree Detail
0.002 Malignant neoplasm of vulva NA BeFree Detail
0.007 Hematologic Neoplasms Detection p53 gene deletion in hematological malignancies using fluorescence in ... BeFree 26035937 Detail
0.002 Roseolovirus Infections NA GAD Detail
0.081 Craniofacial Abnormalities NA BeFree,CTD_mouse Detail
<0.001 Roberts-SC phocomelia syndrome NA BeFree Detail
0.001 dermatofibrosarcoma protuberans NA BeFree Detail
<0.001 nasal type extranodal NK/T-cell lymphoma NA BeFree Detail
<0.001 Laryngeal papillomatosis NA BeFree Detail
0.004 Nijmegen breakage syndrome NA BeFree,GAD Detail
<0.001 Non-alcoholic Fatty Liver Disease NA BeFree Detail
<0.001 Chronic Kidney Insufficiency NA BeFree Detail
<0.001 Hereditary benign telangiectasia (disorder) NA BeFree Detail
<0.001 Rudiger syndrome 1 NA BeFree Detail
0.327 Lung Neoplasms We found that four of the variants (rs3829787, rs3841324, rs588765 and rs3743073... BeFree 23011884 Detail
0.124 choroid plexus carcinoma For children with TP53 mutant malignant gliomas, one year overall survival was 6... BeFree,CLINVAR 25315281 Detail
0.124 choroid plexus carcinoma A greater number of copies of mutated TP53 were significantly associated to incr... BeFree,CLINVAR 25336695 Detail
0.124 choroid plexus carcinoma We show that (i) in the choroid plexus carcinoma, the germline mutation was dete... BeFree,CLINVAR 25787918 Detail
0.124 choroid plexus carcinoma The TP53 mutation detection rate in children presenting with ACC or choroid plex... BeFree,CLINVAR 26014290 Detail
0.004 Trisomy 12 NA BeFree Detail
<0.001 Trisomy 11 NA BeFree Detail
<0.001 Chromosome 9, trisomy NA BeFree Detail
<0.001 Chromosome 8, trisomy NA BeFree Detail
<0.001 Microinvasive carcinoma NA BeFree Detail
0.002 neuropathy NA GAD Detail
<0.001 Desmoplastic infantile astrocytoma NA BeFree Detail
<0.001 Acute monoblastic leukemia NA BeFree Detail
<0.001 Follicular neoplasm NA BeFree Detail
<0.001 Benign pheochromocytoma NA BeFree Detail
<0.001 Plasma cell tumor, malignant NA BeFree Detail
0.001 Leukemia, Prolymphocytic, B-Cell NA BeFree Detail
0.011 Secondary malignant neoplasm of liver Patients with p53 mutations were older (p<.0001) and had higher numbers of liver... BeFree 25003695 Detail
0.011 Secondary malignant neoplasm of liver Assessing the TP53 marker type in patients treated with or without neoadjuvant c... BeFree 25773284 Detail
<0.001 Malignant tumor of eye NA BeFree Detail
0.003 dementia NA BeFree,LHGDN Detail
<0.001 Overweight NA BeFree Detail
<0.001 Benign neurologic neoplasms NA BeFree Detail
<0.001 Chronic active hepatitis NA BeFree Detail
0.012 Recurrent tumor NA BeFree Detail
<0.001 Granulomatosis NA BeFree Detail
<0.001 Associated symptom NA BeFree Detail
<0.001 Neurodegenerative Disorders We discuss the shared properties of cancer and neurodegenerative diseases and ho... BeFree 24775734 Detail
0.011 Hepatitis B, Chronic The p53 mutation spectrum in hepatocellular carcinoma from Guangxi, China : role... BeFree,GAD 24461059 Detail
0.006 Hepatitis C, Chronic FBP1 is barely detectable in normal differentiated cells; its overexpression in ... BeFree,GAD 25995247 Detail
<0.001 Environmental Carcinogenesis NA BeFree Detail
<0.001 Atherosclerotic occlusive disease NA BeFree Detail
<0.001 Myxoid/Round Cell Liposarcoma Normal and functional TP53 in genetically stable myxoid/round cell liposarcoma. BeFree 25393000 Detail
<0.001 Recurrent Carcinoma NA BeFree Detail
0.019 Thyroid carcinoma NA BeFree Detail
<0.001 Oropharynx (excludes nasopharynx) NA BeFree Detail
0.080 Carcinoma of lung For instance, a greater absolute risk reduction of lung and upper aerodigestive ... BeFree 19442246 Detail
0.004 Ewings sarcoma Genomic landscape of Ewing sarcoma defines an aggressive subtype with co-associa... BeFree 25223734 Detail
0.004 Ewings sarcoma A growing collection of retrospective studies have suggested that TP53 mutations... BeFree 25464386 Detail
0.004 Ewings sarcoma CD99 triggering in Ewing sarcoma delivers a lethal signal through p53 pathway re... BeFree 25501132 Detail
0.004 Ewings sarcoma RETRA exerts anticancer activity in Ewing's sarcoma cells independent of their T... BeFree 25801700 Detail
0.004 Oropharyngeal disorders NA BeFree Detail
0.160 Malignant neoplasm of lung For instance, a greater absolute risk reduction of lung and upper aerodigestive ... BeFree 19442246 Detail
0.005 Squamous cell carcinoma of skin To determine the presence of HPV in genital skin squamous cell carcinomas and to... BeFree 25035383 Detail
0.005 Squamous cell carcinoma of skin However, the presence of p53 mutations in skin premalignant lesions suggests tha... BeFree 25639555 Detail
0.016 Malignant glioma Formation of γH2AX foci (a marker of DNA double-strand breaks), rates of foci cl... BeFree 24971978 Detail
0.016 Malignant glioma For children with TP53 mutant malignant gliomas, one year overall survival was 6... BeFree 25315281 Detail
0.003 tongue carcinoma TP53 Pro72 allele is enriched in oral tongue cancer and frequently mutated in es... BeFree 25436609 Detail
0.003 tongue carcinoma The increased expression of pS(21)GSK3α and pS(9)GSK3β not only correlated posit... BeFree 25645517 Detail
<0.001 Tonsillar Carcinoma NA BeFree Detail
<0.001 Carcinoma of anal canal NA BeFree Detail
<0.001 primary sclerosing cholangitis NA BeFree Detail
<0.001 Carotid Atherosclerosis NA BeFree Detail
0.001 Squamous cell carcinoma of mouth NA BeFree Detail
0.031 Osteosarcoma of bone Overexpression of RASSF5 markedly suppressed cell proliferation and invasion, an... BeFree 25109282 Detail
0.031 Osteosarcoma of bone Prognostic value of p53 alterations in human osteosarcoma: a meta analysis. BeFree 25400752 Detail
0.031 Osteosarcoma of bone p53-dependent activation of microRNA-34a in response to etoposide-induced DNA da... BeFree 25490093 Detail
0.031 Osteosarcoma of bone Inactivation of p53 and/or Rb pathways restrains osteoblasts from cell-cycle exi... BeFree 25853231 Detail
0.031 Osteosarcoma of bone Here, we established patient-derived iPSCs from a Li-Fraumeni syndrome (LFS) fam... BeFree 25860607 Detail
0.031 Osteosarcoma of bone Germline TP53 variants and susceptibility to osteosarcoma. BeFree 25896519 Detail
0.031 Osteosarcoma of bone To identify the genes driving osteosarcoma development and metastasis, we perfor... BeFree 25961939 Detail
<0.001 Esophageal dysplasia NA BeFree Detail
<0.001 Biliary Intraepithelial Neoplasia In the printing company cases, immunohistochemical expression of p53 was observe... BeFree 25197345 Detail
<0.001 Costello syndrome (disorder) The most common predisposition syndromes include germline TP53 mutations and con... BeFree 25893277 Detail
0.009 Carcinoma of larynx Together, results suggested that miR-30b could modulate p53 pathway and enhance ... BeFree 25356506 Detail
<0.001 Chemical Carcinogenesis NA BeFree Detail
0.012 Leukemogenesis NA BeFree Detail
<0.001 monocytic leukemia NA BeFree Detail
0.003 Tumor Initiation Using an autochthonous model of pancreatic cancer driven by oncogenic Kras and t... BeFree 24875860 Detail
<0.001 chronic interstitial cystitis NA BeFree Detail
<0.001 Malignant Cystosarcoma Phyllodes NA BeFree Detail
0.003 CARCINOMA OF VULVA NA BeFree Detail
<0.001 Carcinoma testes NA BeFree Detail
0.003 Hashimoto Disease NA BeFree,GAD Detail
0.124 Hereditary Breast and Ovarian Cancer Syndrome NA BeFree,ORPHANET Detail
<0.001 Brain Stem Neoplasms NA BeFree Detail
0.163 Epithelial ovarian cancer High-grade serous ovarian cancer (HG-SOC), a major histologic type of epithelial... BeFree,CTD_human,GAD 24879340 Detail
0.163 Epithelial ovarian cancer Selective tumor cell killing by triptolide in p53 wild-type and p53 mutant ovari... BeFree,CTD_human,GAD 24880464 Detail
0.163 Epithelial ovarian cancer We demonstrated that in a unique population of HGSOC cancer cells with cancer st... BeFree,CTD_human,GAD 25263447 Detail
0.163 Epithelial ovarian cancer TP53 oncomorphic mutations predict resistance to platinum‑ and taxane‑based stan... BeFree,CTD_human,GAD 25385265 Detail
0.163 Epithelial ovarian cancer High-grade serous ovarian cancer (HGSOC) is the most aggressive histological typ... BeFree,CTD_human,GAD 25460179 Detail
0.163 Epithelial ovarian cancer Misregulation of polo-like protein kinase 1, P53 and P21WAF1 in epithelial ovari... BeFree,CTD_human,GAD 25592872 Detail
0.163 Epithelial ovarian cancer To test if TP53 hot spot mutations (HSMs) confer differential chemotherapy resis... BeFree,CTD_human,GAD 25958320 Detail
0.163 Epithelial ovarian cancer The study found a high expression of P53 (64%) and MIB1 (72%) and an expression ... BeFree,CTD_human,GAD 26204652 Detail
0.007 invasive cancer Using an autochthonous model of pancreatic cancer driven by oncogenic Kras and t... BeFree 24875860 Detail
0.002 Progressive Neoplastic Disease Combined MYC family amplifications and P53 pathway defects commonly emerged at r... BeFree 25533335 Detail
<0.001 Refractory cancer NA BeFree Detail
<0.001 Stage III Colorectal Cancer NA BeFree Detail
<0.001 Stage IV Colorectal Cancer NA BeFree Detail
0.001 Complete hydatidiform mole NA BeFree Detail
<0.001 Terminal illness NA BeFree Detail
<0.001 myeloblastosis NA BeFree Detail
0.080 Carcinoma of lung Ectopic expression of miR-506 inhibits NF-κB p65 expression, induces ROS accumul... BeFree 24469051 Detail
0.080 Carcinoma of lung Nickel accumulation in lung tissues is associated with increased risk of p53 mut... BeFree 24711049 Detail
0.080 Carcinoma of lung Rapamycin prevents strong phosphorylation of p53 on serine 46 and attenuates act... BeFree 24915467 Detail
0.080 Carcinoma of lung TP53 mutations and lung cancer: not all mutations are created equal. BeFree 24916693 Detail
0.080 Carcinoma of lung Caveolin-1 regulates lung cancer stem-like cell induction and p53 inactivation i... BeFree 24939878 Detail
0.080 Carcinoma of lung AP-2α downregulation by cigarette smoke condensate is counteracted by p53 in hum... BeFree 25050743 Detail
0.080 Carcinoma of lung β-Elemene against human lung cancer via up-regulation of P53 protein expression ... BeFree 25204604 Detail
0.080 Carcinoma of lung We evaluated 23 single nucleotide polymorphisms (SNPs) in the five nicotinic rec... BeFree 25233467 Detail
0.080 Carcinoma of lung Evaluation of the mutagenicity of anti-B[a]P-diol epoxide with B[a]P-7,8-dione o... BeFree 25279998 Detail
0.080 Carcinoma of lung Loss of p53 function may result in upregulation of 14-3-3γ in lung cancers. BeFree 25384678 Detail
0.080 Carcinoma of lung In addition, we used lung cancer cell lines with different p53 gene background (... BeFree 25398693 Detail
0.080 Carcinoma of lung Finally, we provide an analysis of discerning epidemiological data obtained from... BeFree 25433984 Detail
0.080 Carcinoma of lung SOX30, a novel epigenetic silenced tumor suppressor, promotes tumor cell apoptos... BeFree 25435374 Detail
0.080 Carcinoma of lung Moreover, co-treatment of MML and p53 inhibitor would be more effective in human... BeFree 25490748 Detail
0.080 Carcinoma of lung Thus, we conclude that p53 deficiency and KRAS mutation activate the NF-κB signa... BeFree 25499080 Detail
0.080 Carcinoma of lung Our finding supports that mir-660 acts as a tumor suppressor miRNA and we sugges... BeFree 25501825 Detail
0.080 Carcinoma of lung These results suggest that stroma-derived p53 plays a pivotal role in epithelial... BeFree 25512506 Detail
0.080 Carcinoma of lung Association of a p53 codon 72 gene polymorphism with environmental factors and r... BeFree 25605155 Detail
0.080 Carcinoma of lung We identified mutations in both tumors, including KEAP1 (commonly mutated in lun... BeFree 25850996 Detail
0.080 Carcinoma of lung Treatment of cells with curcumin induced both p53 and the related protein p73 in... BeFree 25910231 Detail
0.080 Carcinoma of lung TP53 Codon 72 Polymorphisms and Lung Cancer Risk in the Bangladeshi Population. BeFree 25921167 Detail
0.080 Carcinoma of lung Furthermore, using data generated by The Cancer Genome Atlas consortium, we demo... BeFree 26063617 Detail
0.080 Carcinoma of lung These results demonstrate that p53 is able to respond to exposure of arsenic or ... BeFree 26091798 Detail
0.080 Carcinoma of lung However, p53-targeted therapies have limited application in lung cancer, since p... BeFree 26093302 Detail
0.080 Carcinoma of lung This RNA aptamer (p53R175H-APT) has a significantly stronger affinity to p53R175... BeFree 26216949 Detail
0.003 Ewings sarcoma-primitive neuroectodermal tumor (PNET) NA BeFree Detail
0.004 Malignant neoplasm of gastrointestinal tract To conduct a phase I trial of a modified vaccinia Ankara (MVA) vaccine deliverin... BeFree 24987057 Detail
<0.001 CNS metastases NA BeFree Detail
0.028 Secondary malignant neoplasm of lymph node LINE-1 hypomethylation of ESCC was significantly associated with lymph node meta... BeFree 24898425 Detail
0.028 Secondary malignant neoplasm of lymph node Increased p53 expression significantly correlated with high pathological grade a... BeFree 25697482 Detail
0.028 Secondary malignant neoplasm of lymph node Our findings underscore the importance of measuring the HPV16 RNA (E6*I) and TP5... BeFree 26095926 Detail
<0.001 heavy drinking NA BeFree Detail
<0.001 Parathyroid Gland Adenocarcinoma NA BeFree Detail
0.005 Pregnancy loss NA GAD Detail
0.064 Carcinoma of bladder Combined CDKN1A/TP53 mutation in bladder cancer is a therapeutic target. BeFree 25349305 Detail
0.064 Carcinoma of bladder Overall results suggest that phosphorylated HER3, ERK1/2 and p53 may be used as ... BeFree 25482142 Detail
0.064 Carcinoma of bladder Our findings confirm the alternative role of FGFR3 and TP53 mutations in the dev... BeFree 25537218 Detail
0.064 Carcinoma of bladder Recent developments in the field of molecular mutational pathway analyses based ... BeFree 25654736 Detail
0.064 Carcinoma of bladder Association of TP53 gene polymorphisms with susceptibility of bladder cancer in ... BeFree 25801242 Detail
<0.001 Malignant Female Reproductive System Neoplasm NA BeFree Detail
0.010 skin carcinoma NA BeFree Detail
0.037 Central neuroblastoma CFM-1, -4, and -5 inhibited NB cell growth, in vitro, independent of their p53 a... BeFree 25033461 Detail
0.037 Central neuroblastoma Simultaneous Adrenocortical Carcinoma and Neuroblastoma in an Infant With a Nove... BeFree 25374282 Detail
0.037 Central neuroblastoma Of note, less than 2% of neuroblastoma tumors have a TP53 mutation at diagnosis. BeFree 25502557 Detail
0.037 Central neuroblastoma Treatment of wild-type TP53 neuroblastoma cell lines with both GSK2830371 and ei... BeFree 25658463 Detail
0.037 Central neuroblastoma Genome wide expression profiling of p53 regulated miRNAs in neuroblastoma. BeFree 25762502 Detail
<0.001 Ependymoblastoma NA BeFree Detail
<0.001 Dissecting aneurysm of the thoracic aorta NA BeFree Detail
<0.001 Carcinoma of glottis NA BeFree Detail
<0.001 bile duct carcinoma NA BeFree Detail
0.002 5q-syndrome L-Leucine improves the anaemia in models of Diamond Blackfan anaemia and the 5q-... BeFree 25098371 Detail
0.001 germ cell cancer NA BeFree Detail
0.003 Malignant neoplasm of kidney NA BeFree Detail
0.001 Poorly differentiated carcinoma NA BeFree Detail
<0.001 cervical cancer squamous cell NA BeFree Detail
<0.001 cyst benign NA BeFree Detail
<0.001 Febrile Neutropenia NA BeFree Detail
<0.001 Cancer of Parotid NA BeFree Detail
<0.001 early pregnancy NA BeFree Detail
<0.001 Sarcoma, metastatic NA BeFree Detail
0.019 Arnold-Chiari Malformation, Type I NA BeFree Detail
0.001 biliary tract cancer NA BeFree Detail
0.002 Brain Tumor, Primary NA BeFree Detail
<0.001 Primary malignant neoplasm of brain Alternative lengthening of telomeres is enriched in, and impacts survival of TP5... BeFree 25315281 Detail
<0.001 Cockayne Syndrome, Type II NA BeFree Detail
<0.001 Cancer, Embryonal NA BeFree Detail
<0.001 Radiation-Induced Cancer NA BeFree Detail
0.009 Well Differentiated Oligodendroglioma Those tumors that lacked LOH 1p19q showed a high frequency of IDH1 mutations and... BeFree 24444336 Detail
0.009 Well Differentiated Oligodendroglioma The mean of Olig2 LI of gliomas with 1p/19q loss ± IDH1/2 mutation, the majority... BeFree 25085214 Detail
0.009 Well Differentiated Oligodendroglioma We found that oligoastrocytomas harbored mutations in TP53 (80%, 12/15) and ATRX... BeFree 25257301 Detail
0.009 Well Differentiated Oligodendroglioma The TP53 and HIST1H3A genes were the hub nodes in the PPI network of DEGs from G... BeFree 25351872 Detail
0.009 Well Differentiated Oligodendroglioma Thus, we analyzed the expression of p-CREB in a series of astrocytomas and oligo... BeFree 25476123 Detail
<0.001 Malignant neoplasm tonsil NA BeFree Detail
<0.001 Genitourinary Cancer NA BeFree Detail
0.001 Cancer of Urinary Tract NA BeFree Detail
0.001 adult acute lymphocytic leukemia NA BeFree Detail
<0.001 Basal Cell Cancer NA BeFree Detail
0.006 Malignant Squamous Cell Neoplasm NA BeFree Detail
<0.001 peripheral nerve sheath neoplasm NA BeFree Detail
0.008 malignant peripheral nerve sheath tumor Human gene copy number alteration data, microarray expression data, and TMA anal... BeFree 24832557 Detail
0.008 malignant peripheral nerve sheath tumor The pathological diagnosis of malignant schwannoma indicated that the p53 expres... BeFree 26146864 Detail
<0.001 Lafora disease We show that loss of laforin or malin results in the increased level and activit... BeFree 26102034 Detail
0.003 brain infarction NA BeFree,GAD Detail
<0.001 spinocerebellar ataxia type 7 In this study we identified a previously unreported mechanism, involving disrupt... BeFree 25647692 Detail
<0.001 Spinal Cord Ischemia NA BeFree Detail
0.002 intracranial thrombosis NA GAD Detail
<0.001 Chromosome 1, monosomy 1p There was no deletion 1p19q in 118 cases, codeletion 1p19q (57 cases), single de... BeFree 25261925 Detail
<0.001 Chromosome 10, monosomy 10q NA BeFree Detail
<0.001 Smith-Magenis syndrome NA BeFree Detail
<0.001 Aicardi-Goutieres syndrome 1 NA BeFree Detail
0.002 malignant pleural mesothelioma MDM2 is an important prognostic and predictive factor for platin-pemetrexed ther... BeFree 25668009 Detail
<0.001 Stage I Endometrial Carcinoma NA BeFree Detail
0.001 Spots on skin Polysomy 7, polysomy 18, p16 deletion, and p53 deletion were significantly more ... BeFree 25517961 Detail
0.001 Spots on skin More than 50% of human cancers contain a mutation or deletion of the p53 gene, a... BeFree 26216949 Detail
<0.001 Uterine carcinoma NA BeFree Detail
0.002 Adenomatous polyp of colon NA BeFree Detail
<0.001 premalignant lesion Using an autochthonous model of pancreatic cancer driven by oncogenic Kras and t... BeFree 24875860 Detail
<0.001 premalignant lesion However, the presence of p53 mutations in skin premalignant lesions suggests tha... BeFree 25639555 Detail
0.006 Helicobacter pylori infection Helicobacter pylori infection and a P53 codon 72 single nucleotide polymorphism:... BeFree 25422197 Detail
0.001 Smoker's lung NA BeFree Detail
<0.001 In situ cancer NA BeFree Detail
0.002 Carcinoma in situ of uterine cervix NA BeFree Detail
0.002 Adenoviral infections NA BeFree Detail
0.001 penis carcinoma NA BeFree Detail
0.004 Invasive breast carcinoma NA BeFree Detail
<0.001 Hepatobiliary neoplasm NA BeFree Detail
<0.001 Pancreatic carcinoma resectable NA BeFree Detail
<0.001 Recurrent Chronic Lymphoid Leukemia NA BeFree Detail
0.001 Rhabdoid Tumor of the Kidney Previous genetic studies on colorectal carcinomas (CRC) have identified multiple... BeFree 25617745 Detail
0.001 Rhabdoid Tumor of the Kidney Taken together, our results provide evidence for RTK/RAS pathway activation and ... BeFree 25795707 Detail
0.001 Rhabdoid Tumor of the Kidney Mutations in genes relating to genome integrity (TP53, BRCA2), chromatin remodel... BeFree 26364057 Detail
<0.001 Adenocarcinoma of lung, stage I NA BeFree Detail
<0.001 Adenocarcinoma of lung, stage IV NA BeFree Detail
<0.001 Recurrent Lung Carcinoma Cell Type Unspecified NA BeFree Detail
<0.001 Undifferentiated (Embryonal) Sarcoma NA BeFree Detail
<0.001 Small Lymphocytic Lymphoma NA BeFree Detail
<0.001 Acute GVH disease NA BeFree Detail
0.122 breast adenocarcinoma The tumor suppressor TP53 is mutated in approximately 30% of breast adenocarcino... BeFree,CLINVAR 25351767 Detail
<0.001 Posterior subcapsular cataract NA BeFree Detail
0.002 Carcinogenicity NA BeFree Detail
<0.001 Medullary carcinoma of breast NA BeFree Detail
<0.001 Malignant melanoma, metastatic NA BeFree Detail
<0.001 Hepatoma recurrent NA BeFree Detail
<0.001 Precursor B-lymphoblastic lymphoma/leukemia NA BeFree Detail
0.001 Borderline ovarian tumour NA BeFree Detail
<0.001 Adenocarcinoma of the prostate metastatic NA BeFree Detail
<0.001 dedifferentiated chondrosarcoma NA BeFree Detail
<0.001 Ewing's tumour localised Tumoral TP53 and/or CDKN2A alterations are not reliable prognostic biomarkers in... BeFree 25464386 Detail
0.002 Hyperkeratosis NA BeFree Detail
<0.001 latent infection NA BeFree Detail
0.002 Advanced cancer Characteristics and survival of patients with advanced cancer and p53 mutations. BeFree 25003695 Detail
0.002 Advanced cancer Cancer genome studies document recurrent genetic inactivation of RB1 and TP53, a... BeFree 25486431 Detail
0.007 Intraepithelial Neoplasia NA BeFree Detail
0.080 Cardiomyopathies NA CTD_mouse Detail
<0.001 Stromal Neoplasm NA BeFree Detail
0.007 Carcinoma, Pancreatic Ductal NA BeFree,GAD,LHGDN Detail
0.003 Optic Atrophy, Hereditary, Leber NA LHGDN Detail
0.078 ovarian neoplasm In this study, we compared the immunoreactivities of Bcl-2, Bax and p53 proteins... BeFree,GAD,LHGDN 25108507 Detail
0.078 ovarian neoplasm Since mutations in TP53 occur in nearly all ovarian tumors, the objective of thi... BeFree,GAD,LHGDN 25385265 Detail
0.002 Genomic Instability NA GAD Detail
0.002 Haematotoxicity NA GAD Detail
0.009 Microsatellite Instability NA GAD Detail
0.002 autoimmune thyroiditis NA GAD Detail
0.002 cancer recurrence NA BeFree Detail
<0.001 cancer regression NA BeFree Detail
<0.001 Renal ischaemia NA BeFree Detail
0.002 Metastatic Prostate Carcinoma NA BeFree Detail
<0.001 blastoma NA BeFree Detail
0.009 precancerous lesions NA BeFree Detail
<0.001 cholecystolithiasis NA BeFree Detail
<0.001 Ischemic stroke NA BeFree Detail
<0.001 Intestinal adenocarcinoma In sporadic intestinal adenocarcinomas with strong p53 immunostaining (mutated T... BeFree 24770931 Detail
0.002 Ovarian adenocarcinoma Strong immunoreactivity of Bcl-2 and mild immunoreactivities of Bax and p53 were... BeFree 25108507 Detail
0.002 Colorectal cancer metastatic Comparison of neuroendocrine differentiation and KRAS/NRAS/BRAF/PIK3CA/TP53 muta... BeFree 25337237 Detail
0.002 Colorectal cancer metastatic Prognostic value of microsatellite instability and p53 expression in metastatic ... BeFree 25474278 Detail
<0.001 coronary restenosis NA BeFree Detail
<0.001 Cancer of lymph node NA BeFree Detail
<0.001 Porokeratosis of Mibelli NA BeFree Detail
<0.001 Hurthle Cell Tumor NA BeFree Detail
<0.001 Tauopathies NA BeFree Detail
0.088 Papillomavirus Infections NA GAD,LHGDN Detail
<0.001 Arthritis, Experimental NA BeFree Detail
<0.001 Chromosome 17 trisomy NA BeFree Detail
<0.001 Bronchial dysplasia NA BeFree Detail
0.008 Invasive Ductal Breast Carcinoma Somatic mutations or deletions of TP53 and PTEN in ductal carcinoma in situ lesi... BeFree,GAD 24531711 Detail
0.008 Invasive Ductal Breast Carcinoma Assessment of changes in the BRCA2 and P53 genes in breast invasive ductal carci... BeFree,GAD 25027116 Detail
0.008 Invasive Ductal Breast Carcinoma Mitochondrial DNA alterations correlate with the pathological status and the imm... BeFree,GAD 25845386 Detail
0.002 Gestational Trophoblastic Neoplasms NA BeFree Detail
<0.001 Plasma cell dyscrasia NA BeFree Detail
0.123 Malignant neoplasm of ovary Mutation or loss of p53 differentially modifies TGFβ action in ovarian cancer. BeFree,GAD 24586866 Detail
0.123 Malignant neoplasm of ovary In this study, the nuclear expression levels of γ-H2AX and p53 using immunohisto... BeFree,GAD 24681744 Detail
0.123 Malignant neoplasm of ovary This study shows that triptolide selectively kills ovarian cancer cells with dif... BeFree,GAD 24880464 Detail
0.123 Malignant neoplasm of ovary Association between a single nucleotide polymorphism in the TP53 region and risk... BeFree,GAD 25060098 Detail
0.123 Malignant neoplasm of ovary The observed upregulation of pro-apoptotic genes and apoptosis in cancer cells w... BeFree,GAD 25096914 Detail
0.123 Malignant neoplasm of ovary Genomic classification of serous ovarian cancer with adjacent borderline differe... BeFree,GAD 25316818 Detail
0.123 Malignant neoplasm of ovary Furthermore, tumors containing oncomorphic TP53 mutations displayed unique prote... BeFree,GAD 25385265 Detail
0.123 Malignant neoplasm of ovary TP53 remains as the most frequently altered gene in high grade serous ovarian ca... BeFree,GAD 25404506 Detail
0.123 Malignant neoplasm of ovary Detection of somatic TP53 mutations in tampons of patients with high-grade serou... BeFree,GAD 25437714 Detail
0.123 Malignant neoplasm of ovary Molecular characterization of an intact p53 pathway subtype in high-grade serous... BeFree,GAD 25460179 Detail
0.123 Malignant neoplasm of ovary Although the effect of new drugs such as poly(ADP-ribose) polymerase inhibitors ... BeFree,GAD 25473022 Detail
0.123 Malignant neoplasm of ovary Co-immunoprecipitation and western blotting showed significantly lower levels of... BeFree,GAD 25510663 Detail
0.123 Malignant neoplasm of ovary The present study aimed to clarify the role of PLK1, P53 and P21WAF1 in the prog... BeFree,GAD 25592872 Detail
0.123 Malignant neoplasm of ovary CR389, a benzoimidazolyl pyridinone analog, induces cell cycle arrest and apopto... BeFree,GAD 25639717 Detail
0.123 Malignant neoplasm of ovary Overall, FBN1, acts at the downstream of Aur A and BRCA2, promotes ovarian cance... BeFree,GAD 25749384 Detail
0.123 Malignant neoplasm of ovary First, we observed the upregulation protein level of p53 target genes in cisplat... BeFree,GAD 25820823 Detail
0.123 Malignant neoplasm of ovary There is a link between miR-7 expression and TP53 status and tumour grade in ser... BeFree,GAD 25862909 Detail
0.123 Malignant neoplasm of ovary TP53 hot spot mutations in ovarian cancer: selective resistance to microtubule s... BeFree,GAD 25958320 Detail
0.123 Malignant neoplasm of ovary We propose that this unique ability of APR-246/MQ to bind to cysteines in both m... BeFree,GAD 26086967 Detail
<0.001 X-linked dyskeratosis congenita NA BeFree Detail
0.004 endometrial adenocarcinoma NA BeFree Detail
<0.001 Stage I Gallbladder Carcinoma NA BeFree Detail
<0.001 Skin toxicity NA BeFree Detail
<0.001 Recurrent respiratory papillomatosis NA BeFree Detail
<0.001 High-Grade Prostatic Intraepithelial Neoplasia NA BeFree Detail
0.172 Squamous cell carcinoma of the head and neck Mechanistic studies reveal that attenuated HNSCC cell growth in response to DEK ... BeFree,CTD_human,GAD 24608431 Detail
0.172 Squamous cell carcinoma of the head and neck Increased growth-inhibitory and cytotoxic activity of arsenic trioxide in head a... BeFree,CTD_human,GAD 24927258 Detail
0.172 Squamous cell carcinoma of the head and neck Predicting survival in head and neck squamous cell carcinoma from TP53 mutation. BeFree,CTD_human,GAD 25108461 Detail
0.172 Squamous cell carcinoma of the head and neck We previously showed that CK2 is often aberrantly expressed and activated in hea... BeFree,CTD_human,GAD 25379016 Detail
0.172 Squamous cell carcinoma of the head and neck Emphasis is placed on the therapeutic implications of genes frequently altered i... BeFree,CTD_human,GAD 25440877 Detail
0.172 Squamous cell carcinoma of the head and neck These results indicate that HNSCC cells expressing high-risk p53 mutations are s... BeFree,CTD_human,GAD 25504633 Detail
0.172 Squamous cell carcinoma of the head and neck TP53 is the most frequently altered gene in head and neck squamous cell carcinom... BeFree,CTD_human,GAD 25634208 Detail
0.172 Squamous cell carcinoma of the head and neck The EAp53 approach clearly identifies a subset of high-risk TP53 mutations assoc... BeFree,CTD_human,GAD 25691460 Detail
0.172 Squamous cell carcinoma of the head and neck Combined TP53 mutation/3p loss correlates with decreased radiosensitivity and in... BeFree,CTD_human,GAD 25735654 Detail
0.172 Squamous cell carcinoma of the head and neck Human papillomavirus (HPV), p16 expression, and TP53 mutations are known prognos... BeFree,CTD_human,GAD 25871546 Detail
0.172 Squamous cell carcinoma of the head and neck Homozygous deletions of UGT2B17 modifies effects of smoking on TP53-mutations an... BeFree,CTD_human,GAD 25886176 Detail
0.172 Squamous cell carcinoma of the head and neck Our findings underscore the importance of measuring the HPV16 RNA (E6*I) and TP5... BeFree,CTD_human,GAD 26095926 Detail
0.012 Ductal Carcinoma NA BeFree,LHGDN Detail
0.002 Chromosomal Instability NA GAD Detail
<0.001 Mammary Carcinoma, Human NA BeFree Detail
<0.001 Myxoid cyst NA BeFree Detail
0.003 Anemia, Diamond-Blackfan Haploinsufficiency of ribosomal proteins (RPs) and upregulation of the tumour su... BeFree 25098371 Detail
0.003 Anemia, Diamond-Blackfan In this study, we establish the DBA model in zebrafish using an RPS24 morpholino... BeFree 25189322 Detail
0.400 sarcoma Genetic depletion of Snail1 in MSCs that are deficient in p53 tumor suppressor d... BeFree,CLINVAR,CTD_human,CTD_mouse,GAD,LHGDN 24947186 Detail
0.400 sarcoma Most childhood sarcomas are TP53 wild type at diagnosis, although approximately ... BeFree,CLINVAR,CTD_human,CTD_mouse,GAD,LHGDN 25832557 Detail
<0.001 Persistent infection NA BeFree Detail
<0.001 large cell neuroendocrine carcinoma NA BeFree Detail
<0.001 basaloid squamous cell carcinoma NA BeFree Detail
<0.001 Trichilemmocarcinoma NA BeFree Detail
<0.001 Papillary transitional cell neoplasm of low malignant potential NA BeFree Detail
<0.001 Traditional Serrated Adenoma NA BeFree Detail
<0.001 Atypical carcinoid tumor NA BeFree Detail
<0.001 sarcomatoid renal cell carcinoma NA BeFree Detail
<0.001 atypical follicular adenoma NA BeFree Detail
<0.001 eccrine porocarcinoma NA BeFree Detail
<0.001 Atypical medullary carcinoma NA BeFree Detail
<0.001 Thymic epithelial tumor TP53 was the most frequently mutated gene in TETs (n = 13; 17%), especially in T... BeFree 25482724 Detail
<0.001 Solitary fibrous tumor Two dedifferentiated SFT cases harbored both TP53 and TERT promoter mutations. BeFree 25582503 Detail
0.001 pleuropulmonary blastoma Exome sequencing of pleuropulmonary blastoma reveals frequent biallelic loss of ... BeFree 24909177 Detail
<0.001 Intratubular malignant germ cells NA BeFree Detail
<0.001 Nonseminomatous germ cell tumor NA BeFree Detail
<0.001 Intracortical osteosarcoma NA BeFree Detail
<0.001 clear cell chondrosarcoma NA BeFree Detail
<0.001 gliofibroma NA BeFree Detail
<0.001 Mild cognitive disorder NA BeFree Detail
<0.001 Tumor stage mycosis fungoides NA BeFree Detail
<0.001 Avellino corneal dystrophy These accumulations were associated with decreased levels of Cyclin A1, B1, and ... BeFree 25450621 Detail
<0.001 Transitional cell dysplasia NA BeFree Detail
<0.001 Cutaneous lymphoma NA BeFree Detail
<0.001 Vascular degeneration NA BeFree Detail
<0.001 Inflammatory disorder NA BeFree Detail
<0.001 Chronic inflammatory disorder NA BeFree Detail
0.004 Primary Effusion Lymphoma NA BeFree,LHGDN Detail
0.004 Precursor B-cell lymphoblastic leukemia We identified a unique case of adult B-ALL with masked low hypodiploidy (mLH) by... BeFree 26185311 Detail
<0.001 Therapy-related acute myeloid leukemia and myelodysplastic syndrome Our findings support the recent notion that heterozygous TP53 mutation may be a ... BeFree 25952993 Detail
<0.001 Aggressive natural killer-cell leukemia NA BeFree Detail
<0.001 Chronic myeloproliferative disorder We performed genomic profiling of post-MPN AML samples; these studies demonstrat... BeFree 25516983 Detail
0.002 Myelodysplastic Syndrome with Isolated del(5q) L-Leucine improves the anaemia in models of Diamond Blackfan anaemia and the 5q-... BeFree 25098371 Detail
0.001 Therapy-related myelodysplastic syndrome The early acquisition of TP53 mutations in the founding HSPC clone probably cont... BeFree 25487151 Detail
0.001 Therapy-related myelodysplastic syndrome TP53 mutations are highly and similarly prevalent in t-MDS and t-AML but mutatio... BeFree 25573287 Detail
0.001 Therapy-related myelodysplastic syndrome TP53 mutation characteristics in therapy-related myelodysplastic syndromes and a... BeFree 25952993 Detail
0.001 Single tumor NA BeFree Detail
<0.001 Perivascular Epithelioid Cell Neoplasms Coexistent TP53 mutations were identified in 63% of the TSC2-mutated PEComas. BeFree 25651471 Detail
0.001 Pancreatic intraepithelial neoplasia We explored lncRNAs profilings in PanIN cell line (SH-PAN) isolated from Pdx-1-C... BeFree 24469904 Detail
0.001 Pancreatic intraepithelial neoplasia The authors show that combined loss of autophagy and p53 dramatically promotes p... BeFree 24939064 Detail
<0.001 Salivary duct carcinoma NA BeFree Detail
<0.001 Post-transplant lymphoproliferative disorder, polymorphic NA BeFree Detail
0.012 Adenoma of large intestine NA BeFree,GAD Detail
<0.001 chronic lymphocytic leukemia/small lymphocytic lymphoma NA BeFree Detail
<0.001 Low Grade Squamous Intraepithelial Neoplasia NA BeFree Detail
<0.001 ACTH-secreting pituitary adenoma NA BeFree Detail
<0.001 Ameloblastic carcinoma This is the first case of ameloblastic carcinoma with a mutation of the p53 gene... BeFree 24906942 Detail
<0.001 Astrocytoma, low grade NA BeFree Detail
<0.001 Liver regeneration disorder NA BeFree Detail
<0.001 Non-toxic nodular goiter NA BeFree Detail
<0.001 M5b Acute differentiated monocytic leukemia NA BeFree Detail
<0.001 Congenital melanocytic nevus NA BeFree Detail
0.007 Adenocarcinoma of large intestine TP53 status regulates ACSL5-induced expression of mitochondrial mortalin in ente... BeFree 24770931 Detail
0.001 Squamous cell carcinoma of pharynx NA BeFree Detail
<0.001 Blood in stool NA BeFree Detail
<0.001 Thymoma, type C Massively parallel sequencing identifies recurrent mutations in TP53 in thymic c... BeFree 25299233 Detail
<0.001 Thymoma, type C TP53 was the most frequently mutated gene in TETs (n = 13; 17%), especially in T... BeFree 25482724 Detail
<0.001 pancreatic endocrine carcinoma NA BeFree Detail
<0.001 Hormone refractory prostate cancer NA BeFree Detail
<0.001 Acute Myeloid Leukemia Arising from Previous Myelodysplastic Syndrome NA BeFree Detail
<0.001 Adenoid cystic breast carcinoma NA BeFree Detail
<0.001 Adult Diffuse Astrocytoma NA BeFree Detail
<0.001 Aggressive Non-Hodgkin Lymphoma Chromosome instability induced by Mps1 and p53 mutation generates aggressive lym... BeFree 25197064 Detail
0.002 Atypical Ductal Breast Hyperplasia NA BeFree Detail
<0.001 Breast Fibrocystic Change, Proliferative Type NA BeFree Detail
<0.001 Cerebellar Glioblastoma NA BeFree Detail
<0.001 Classical Hodgkin's Lymphoma NA BeFree Detail
<0.001 Colon Carcinoma Metastatic in the Liver NA BeFree Detail
<0.001 Endometrial intraepithelial neoplasia NA BeFree Detail
<0.001 endometrial squamous cell carcinoma NA BeFree Detail
<0.001 Esophageal Basaloid Carcinoma NA BeFree Detail
0.008 Hereditary Malignant Neoplasm Five new TP53 mutations were identified in six pedigrees from hereditary cancer ... BeFree 25925845 Detail
0.001 gastric cardia adenocarcinoma NA BeFree Detail
<0.001 gastric cardia carcinoma NA BeFree Detail
<0.001 Gastric Mucosa-Associated Lymphoid Tissue Lymphoma NA BeFree Detail
<0.001 Hepatitis B Virus-Related Hepatocellular Carcinoma NA BeFree Detail
<0.001 Hepatitis C Virus-Related Hepatocellular Carcinoma NA BeFree Detail
0.005 Hereditary Nonpolyposis Colorectal Cancer NA BeFree,GAD Detail
<0.001 Hereditary Ovarian Carcinoma NA BeFree Detail
<0.001 High Grade Cervical Intraepithelial Neoplasia NA BeFree Detail
<0.001 High Grade Intraepithelial Neoplasia NA BeFree Detail
<0.001 Human Papillomavirus-Related Esophageal Squamous Cell Carcinoma NA BeFree Detail
<0.001 Intermediate Grade Ductal Breast Carcinoma In Situ NA BeFree Detail
<0.001 Intramuscular Myxoma NA BeFree Detail
0.008 Invasive Carcinoma NA BeFree Detail
<0.001 Infiltrating Bladder Urothelial Carcinoma NA BeFree Detail
<0.001 Inverted Urothelial Papilloma NA BeFree Detail
<0.001 Low Grade Ductal Breast Carcinoma In Situ NA BeFree Detail
0.001 Malignant Mixed Mesodermal (Mullerian) Tumor NA BeFree Detail
<0.001 maxillary sinus squamous cell carcinoma NA BeFree Detail
<0.001 Metaplastic breast carcinoma NA BeFree Detail
<0.001 Multifocal osteosarcoma NA BeFree Detail
<0.001 nasal cavity adenocarcinoma NA BeFree Detail
<0.001 Nodular Neoplasm NA BeFree Detail
<0.001 Non-Hereditary Clear Cell Renal Cell Carcinoma Genetic inactivation of the TP53 gene in ccRCC is rare, suggesting that an alter... BeFree 24469044 Detail
<0.001 Occupational Malignant Neoplasm NA BeFree Detail
<0.001 Oligodendroglial Neoplasm Mutations in TP53 (20/28, 71%) and ATRX (15/28, 54%) were enriched in astrocytic... BeFree 25257301 Detail
<0.001 Ovarian Mucinous Tumor NA BeFree Detail
<0.001 Ovarian Serous Adenocarcinoma NA BeFree Detail
0.009 pancreatic ductal adenocarcinoma On the other hand, in well-differentiated PDACs measuring ≤ 1 cm, the incidence ... BeFree 24297432 Detail
0.009 pancreatic ductal adenocarcinoma We explored lncRNAs profilings in PanIN cell line (SH-PAN) isolated from Pdx-1-C... BeFree 24469904 Detail
0.009 pancreatic ductal adenocarcinoma Mutations in p53 and RAS potently cooperate in oncogenic transformation, and cor... BeFree 24794439 Detail
0.009 pancreatic ductal adenocarcinoma Based on these findings, we propose the existence of a hierarchical signaling ne... BeFree 25586376 Detail
0.009 pancreatic ductal adenocarcinoma Impact of TP53 codon 72 and MDM2 SNP 309 polymorphisms in pancreatic ductal aden... BeFree 25734904 Detail
0.009 pancreatic ductal adenocarcinoma Using genetically engineered mouse models, we show that heterozygous mutation of... BeFree 26004068 Detail
<0.001 Carcinoma ex pleomorphic adenoma of parotid gland NA BeFree Detail
<0.001 Conventional Chondrosarcoma NA BeFree Detail
0.004 Primary Carcinoma NA BeFree Detail
<0.001 Recurrent Head and Neck Carcinoma NA BeFree Detail
<0.001 Breast Sclerosing Adenosis NA BeFree Detail
<0.001 Vulvar Intraepithelial Neoplasia, Differentiated Type NA BeFree Detail
<0.001 Squamous Lung Dysplasia NA BeFree Detail
<0.001 Stage IIIB Cervical Carcinoma NA BeFree Detail
0.004 Carcinoma of urinary bladder, superficial NA BeFree Detail
<0.001 supratentorial primitive neuroectodermal tumor NA BeFree Detail
<0.001 Testicular Germ Cell Tumor A miR-199a/miR-214 self-regulatory network via PSMD10, TP53 and DNMT1 in testicu... BeFree 25231260 Detail
<0.001 Treatment related acute myeloid leukaemia NA BeFree Detail
<0.001 Thymic Lymphoma However, this interpretation has been challenged by a number of recent in vivo s... BeFree 25618545 Detail
<0.001 thyroid lymphoma NA BeFree Detail
<0.001 Uterine Angiosarcoma NA BeFree Detail
<0.001 Endometrial Endometrioid Adenocarcinoma NA BeFree Detail
<0.001 Well Differentiated Pancreatic Endocrine Tumor We detected a total of 1,764 nonsynonymous single nucleotide variants at a rate ... BeFree 26087898 Detail
0.002 differentiated thyroid gland carcinoma NA BeFree Detail
<0.001 Hypopharyngeal Carcinoma NA BeFree Detail
0.007 Epithelioma NA BeFree Detail
<0.001 mature teratoma NA BeFree Detail
<0.001 Granulosa cell tumor of the ovary NA BeFree Detail
<0.001 Liposarcoma, well differentiated NA BeFree Detail
<0.001 carcinoma of the renal pelvis and ureter NA BeFree Detail
<0.001 Prostate cancer stage C NA BeFree Detail
<0.001 Pleural Mesothelioma NA BeFree Detail
<0.001 Undifferentiated leukemia Genetic deletion of the telomerase subunit Terc in a retroviral mouse AML model ... BeFree 25479751 Detail
0.003 renal carcinoma NA BeFree Detail
<0.001 Metastatic Carcinoma NA BeFree Detail
<0.001 Conn Syndrome NA BeFree Detail
0.002 Primary Lesion NA BeFree Detail
<0.001 Vascular lesions NA BeFree Detail
<0.001 Infiltrating duct carcinoma NA BeFree Detail
<0.001 anal squamous cell carcinoma NA BeFree Detail
<0.001 Disseminated carcinoma NA BeFree Detail
<0.001 Chronic esophagitis NA BeFree Detail
<0.001 Posterior capsule opacification NA BeFree Detail
0.004 Cardiomyopathy, Familial Idiopathic NA BeFree Detail
0.002 Benign melanocytic nevus NA BeFree Detail
0.353 Mammary Neoplasms We have predicted three deleterious coding non-synonymous single nucleotide poly... BeFree,CTD_human,CTD_mouse,GAD,LHGDN 25105660 Detail
0.353 Mammary Neoplasms Here, we investigated the role of p53 in breast tumor cell invasion, migration, ... BeFree,CTD_human,CTD_mouse,GAD,LHGDN 25257729 Detail
0.353 Mammary Neoplasms Lymphocyte Invasion in IC10/Basal-Like Breast Tumors Is Associated with Wild-Typ... BeFree,CTD_human,CTD_mouse,GAD,LHGDN 25351767 Detail
0.353 Mammary Neoplasms A positive correlation was found between expression of mutant gene p53 protein a... BeFree,CTD_human,CTD_mouse,GAD,LHGDN 25403404 Detail
0.353 Mammary Neoplasms Through the described mechanism, elevated CXCR5 expression may contribute to abn... BeFree,CTD_human,CTD_mouse,GAD,LHGDN 25786345 Detail
0.353 Mammary Neoplasms These results have translational relevance, demonstrating that TP53 mutant breas... BeFree,CTD_human,CTD_mouse,GAD,LHGDN 26063617 Detail
<0.001 histiocytoma NA BeFree Detail
<0.001 choroid plexus carcinoma, childhood NA BeFree Detail
<0.001 Epididymal Adenocarcinoma Molecular genetic analysis revealed an uncommon mutation; 249: AGG →ATG in the T... BeFree 25839701 Detail
<0.001 Angiogenic Switch NA BeFree Detail
<0.001 Desmoplastic NA BeFree Detail
<0.001 differentiating neuroblastoma NA BeFree Detail
<0.001 grade I meningioma NA BeFree Detail
0.017 Hepatocarcinogenesis The aims of present study are to investigate the p53 mutation spectrum in HBV- a... BeFree 24461059 Detail
0.017 Hepatocarcinogenesis It is concluded that both of the non-structural genes, NS3 and NS5A, of HCV play... BeFree 24845365 Detail
0.017 Hepatocarcinogenesis Hepatitis B Virus Core Promoter A1762T/G1764A (TA)/T1753A/T1768A Mutations Contr... BeFree 25567052 Detail
<0.001 Hereditary Melanoma NA BeFree Detail
0.002 Mammary Tumorigenesis Mutant p53 Amplifies Epidermal Growth Factor Receptor Family Signaling to Promot... BeFree 25573952 Detail
0.002 Primary Glioblastoma NA BeFree Detail
<0.001 Primary Peritoneal Carcinoma NA BeFree Detail
0.003 Cancer Cell Growth A cell-permeable TAT-p53LZ2 effectively inhibits the cancer cell growth in wild-... BeFree 24804811 Detail
0.003 Cancer Cell Growth However, whether INZ could suppress cancer cell growth independently of p53 acti... BeFree 25692307 Detail
0.002 Serous Endometrial Intraepithelial Carcinoma NA BeFree Detail
<0.001 Ganglioneuroblastoma, Nodular NA BeFree Detail
0.003 Malignant Conversion NA BeFree Detail
<0.001 ovarian clear cell adenocarcinoma NA BeFree Detail
0.002 Secondary Glioblastoma NA BeFree Detail
0.007 Skin Carcinogenesis NA BeFree Detail
0.004 Tumor Angiogenesis NA BeFree Detail
<0.001 Tumor Immunity NA BeFree Detail
<0.001 Tumor Promotion NA BeFree Detail
<0.001 Type II Endometrial Adenocarcinoma These results indicate that absence of CDH1 and TP53 in endometrial cells initia... BeFree 24998851 Detail
<0.001 Undifferentiated Neuroblastoma NA BeFree Detail
<0.001 Urothelial Neoplasm Our results support the idea that mutations of the FGFR3 and TP53 genes are rare... BeFree 24743222 Detail
<0.001 Urothelial Neoplasm In the Balkan and Taiwan, the relationship between exposure to aristolochic acid... BeFree 25184754 Detail
0.004 Xenograft Model Re-engineered p53 activates apoptosis in vivo and causes primary tumor regressio... BeFree 25077773 Detail
0.004 Xenograft Model In this study, Hep3B cells which are p53 null were used to investigate the anti-... BeFree 25371988 Detail
0.002 Ductal Breast Carcinoma NA BeFree Detail
<0.001 Morphea NA BeFree Detail
0.003 Rectal Tumors Elevated p57Kip2 induces G1/S phase cell cycle arrest but inhibits cell death in... BeFree 25195859 Detail
<0.001 smoldering myeloma NA BeFree Detail
<0.001 Pneumocystis jiroveci pneumonia Cytoplasmic/nuclear beta-catenin and P53 accumulation was observed in the majori... BeFree 24717047 Detail
0.003 Rash and Dermatitis Adverse Event Associated with Chemoradiation NA BeFree Detail
<0.001 Non-Malignant Ascites Adverse Event NA BeFree Detail
<0.001 Chronic Kidney Diseases NA BeFree Detail
0.002 Adenocarcinoma, Endometrioid ECCCs had SCA-like features with rare expression of estrogen receptor/progestero... BeFree 25473756 Detail
0.014 Glioblastoma multiforme However, p53 therapy for GBM is limited by lack of efficient delivery across the... BeFree,GAD 24811110 Detail
0.014 Glioblastoma multiforme A tumor-targeting p53 nanodelivery system limits chemoresistance to temozolomide... BeFree,GAD 25240597 Detail
0.014 Glioblastoma multiforme Detection of p53 mutations in proliferating vascular cells in glioblastoma multi... BeFree,GAD 25415071 Detail
0.014 Glioblastoma multiforme It has been found that the reintroduction of WWOX induced p53-mutant GBM cells t... BeFree,GAD 25432984 Detail
0.002 Cirrhosis NA BeFree Detail
0.001 androgen independent prostate cancer NA BeFree Detail
<0.001 Grade I Astrocytoma NA BeFree Detail
0.002 Benign Prostatic Hyperplasia NA BeFree Detail
<0.001 Enchondroma NA BeFree Detail
<0.001 Carcinoma of Endocrine Gland NA BeFree Detail
<0.001 Uterine Corpus Carcinosarcoma NA BeFree Detail
<0.001 Skin Pigmentation Disorder NA BeFree Detail
<0.001 Anaplastic Rhabdomyosarcoma NA BeFree Detail
<0.001 Colorectal Mucinous Adenocarcinoma NA BeFree Detail
<0.001 Colorectal Signet Ring Cell Carcinoma NA BeFree Detail
<0.001 Colorectal Small Cell Neuroendocrine Carcinoma NA BeFree Detail
<0.001 hereditary diffuse gastric cancer NA BeFree Detail
<0.001 Keratocystic Odontogenic Tumor The C/C genotype of P53 gene codon 72 increases the risk of developing sporadic ... BeFree 25773801 Detail
<0.001 Low grade appendiceal mucinous neoplasm Nuclear positive reaction of TP53 was lower in LAMN compared with those of other... BeFree 25155618 Detail
0.008 Non-Neoplastic Disorder In the printing company cases, immunohistochemical expression of p53 was observe... BeFree 25197345 Detail
0.008 Non-Neoplastic Disorder Non-neoplastic (n=28), noninvasive (n=28), and invasive (n=11) spots were then a... BeFree 25517961 Detail
<0.001 Pyothorax-Associated Lymphoma NA BeFree Detail
<0.001 paranasal sinus and nasal cavity cancer NA BeFree Detail
<0.001 Unilateral Breast Carcinoma NA BeFree Detail
0.003 Meningioma, benign, no ICD-O subtype NA BeFree Detail
0.003 Idiopathic Pulmonary Fibrosis NA BeFree Detail
0.002 Chromosome 5, trisomy 5q L-Leucine improves the anaemia in models of Diamond Blackfan anaemia and the 5q-... BeFree 25098371 Detail
<0.001 UV-sensitive syndrome NA BeFree Detail
<0.001 IMMUNE SUPPRESSION NA BeFree Detail
<0.001 MULTICYSTIC RENAL DYSPLASIA, BILATERAL NA BeFree Detail
<0.001 VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding) NA BeFree Detail
<0.001 Familial ependymoma NA BeFree Detail
<0.001 lateral meningocele syndrome NA BeFree Detail
0.080 DYSKERATOSIS CONGENITA, AUTOSOMAL DOMINANT NA MGD Detail
<0.001 Prostate Cancer, Hereditary, 7 NA BeFree Detail
<0.001 BREAST CANCER 3 NA BeFree Detail
0.120 Adrenocortical carcinoma, hereditary NA CTD_human Detail
0.120 Adrenocortical carcinoma, pediatric Prevalence and functional consequence of TP53 mutations in pediatric adrenocorti... BeFree,CLINVAR 25584008 Detail
0.120 Leukemia, Megakaryoblastic, of Down Syndrome NA CTD_human Detail
<0.001 Breast Cancer, Familial Male Mutational profiling of familial male breast cancers reveals similarities with l... BeFree 25490678 Detail
<0.001 campomelic dysplasia NA BeFree Detail
<0.001 Amyotrophic Lateral Sclerosis, Sporadic NA BeFree Detail
<0.001 POROKERATOSIS, DISSEMINATED SUPERFICIAL ACTINIC, 1 NA BeFree Detail
<0.001 PHOTOPAROXYSMAL RESPONSE 1 NA BeFree Detail
<0.001 B-CELL MALIGNANCY, LOW-GRADE NA BeFree Detail
0.002 Inverted Squamous Cell Papilloma No variation of p16, p21, PLUNC (palate, lung, and nasal epithelium clone protei... BeFree 25013792 Detail
0.003 Malformations of Cortical Development NA LHGDN Detail
<0.001 Trichothiodystrophy Syndromes NA BeFree Detail
0.007 coronary artery disease NA BeFree,GAD Detail
0.006 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Nucleostemin knocking-down causes cell cycle arrest and apoptosis in human T-cel... BeFree,GAD 24628257 Detail
0.139 Precursor Cell Lymphoblastic Leukemia Lymphoma NA BeFree,CTD_human,GAD,LHGDN Detail
<0.001 low grade glioma Mapping p53 mutations in low-grade glioma: a voxel-based neuroimaging analysis. BeFree 25104286 Detail
<0.001 Leukemia, B-Cell NA BeFree Detail
0.006 Urothelial Carcinoma We also found significant inverse correlation between FGFR3 mutations and TP53 a... BeFree 25537218 Detail
0.006 Urothelial Carcinoma Taken together, our results provide evidence for RTK/RAS pathway activation and ... BeFree 25795707 Detail
<0.001 eyelids (symptom) UV-independent p53 mutations in sebaceous carcinoma of the eyelid. BeFree 24777261 Detail
<0.001 benign mastocytoma NA BeFree Detail
<0.001 Childhood myelodysplastic syndrome NA BeFree Detail
<0.001 Triple-negative breast carcinoma NA BeFree Detail
0.003 Oropharyngeal Carcinoma Among these biomarkers, p53 is the strongest prognostic marker in OPC and p53 in... BeFree 25380690 Detail
0.003 Oropharyngeal Carcinoma The biology of HPV-positive oropharyngeal cancer is distinct; it includes p53 de... BeFree 26563006 Detail
<0.001 T-cell prolymphocytic leukemia NA BeFree Detail
<0.001 Benign multiple sclerosis NA BeFree Detail
0.120 Acute kidney injury NA CTD_human Detail
0.126 Li-fraumeni-like syndrome Targeted, massively parallel DNA sequencing and molecular inversion probe microa... BeFree,CLINVAR 25588929 Detail
0.126 Li-fraumeni-like syndrome She presented with a clinical diagnosis of Li-Fraumeni-like syndrome (LFL), show... BeFree,CLINVAR 25935441 Detail
0.126 Li-fraumeni-like syndrome A significant percentage (5-10%) of pediatric cancers are associated with heredi... BeFree,CLINVAR 26248253 Detail
<0.001 Hypodiploid B Acute Lymphoblastic Leukemia NA BeFree Detail
<0.001 Dedifferentiated Solitary Fibrous Tumor NA BeFree Detail
<0.001 Hepatitis B and hepatitis C NA BeFree Detail
<0.001 Alcoholic Steatohepatitis NA BeFree Detail
<0.001 Sessile Serrated Adenoma/Polyp NA BeFree Detail
<0.001 Lentigo maligna melanoma NA BeFree Detail
0.006 Promyelocytic leukemia NA BeFree,GAD Detail
0.002 XERODERMA PIGMENTOSUM, COMPLEMENTATION GROUP C NA BeFree Detail
<0.001 Treatment related leukaemia NA BeFree Detail
<0.001 Human Papillomavirus Positive Oropharyngeal Squamous Cell Carcinoma NA BeFree Detail
0.006 Chronic ulcerative colitis NA BeFree,GAD Detail
<0.001 Cavernous Hemangioma of Brain NA BeFree Detail
0.120 Pancreatic carcinoma, familial NA BeFree,ORPHANET Detail
<0.001 Desmoplastic cerebral astrocytoma of infancy NA BeFree Detail
0.002 Gestational trophoblastic disease NA BeFree Detail
0.120 Chromosome 17 deletion NA CTD_human Detail
0.261 Nasopharyngeal carcinoma In addition, it stimulated p53 promoter activity and downregulated the protein e... BeFree,CLINVAR,CTD_human,GAD 25231528 Detail
0.261 Nasopharyngeal carcinoma Collectively, these results suggest that LOC401317 is directly regulated by p53 ... BeFree,CLINVAR,CTD_human,GAD 25422887 Detail
0.261 Nasopharyngeal carcinoma The results suggested that the Arg399Gln polymorphism of XRCC1 gene, the 1G/2G p... BeFree,CLINVAR,CTD_human,GAD 25481674 Detail
0.261 Nasopharyngeal carcinoma Association between p53 codon 72 polymorphisms and clinical outcome of nasophary... BeFree,CLINVAR,CTD_human,GAD 25526208 Detail
<0.001 Obesity, Visceral NA BeFree Detail
0.002 Prostatic Hyperplasia NA GAD Detail
<0.001 myeloid neoplasm Persistent STAT5 activation in myeloid neoplasms recruits p53 into gene regulati... BeFree 24681953 Detail
<0.001 aggressive cancer Malignant melanoma is a highly aggressive cancer that retains functional p53 and... BeFree 25071017 Detail
<0.001 childhood liver cancer NA BeFree Detail
<0.001 Refractory anemia, without ringed sideroblasts, without excess blasts NA BeFree Detail
<0.001 Bisphosphonate-associated osteonecrosis NA BeFree Detail
<0.001 Multicentric Breast Carcinoma NA BeFree Detail
<0.001 Early-Stage Breast Carcinoma NA BeFree Detail
<0.001 Esophageal Spindle Cell Carcinoma NA BeFree Detail
<0.001 Gastric Carcinoma with Lymphoid Stroma NA BeFree Detail
<0.001 Stage III Colorectal Cancer AJCC v7 NA BeFree Detail
<0.001 Stage IV Colorectal Cancer AJCC v7 NA BeFree Detail
0.001 Stage III Colon Cancer AJCC v7 NA BeFree Detail
<0.001 Stage III Breast Cancer AJCC v7 NA BeFree Detail
<0.001 GASTRIC CANCER, INTESTINAL NA BeFree Detail
0.002 Hypotension Adverse Event NA GAD Detail
<0.001 Chondrosarcoma of bone NA BeFree Detail
<0.001 Nonalcoholic Steatohepatitis NA BeFree Detail
0.005 Solar Erythema NA GAD Detail
<0.001 Condylomatous carcinoma Diffuse p16 expression was associated with younger age at presentation (P<0.0001... BeFree 26171917 Detail
<0.001 Ischemic Cerebrovascular Accident NA BeFree Detail
<0.001 Ulcerative Colitis-Associated Colorectal Adenocarcinoma NA BeFree Detail
<0.001 Biliary System Disorder NA BeFree Detail
0.002 Hydatidiform mole, recurrent, 1 NA BeFree Detail
0.004 FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder) Forty-two deleterious germline mutations were identified in 21 genes of 34 patie... BeFree 25927356 Detail
<0.001 Micropapillary carcinoma NA BeFree Detail
<0.001 Neuroepithelioma, Peripheral NA BeFree Detail
<0.001 Lipomatosis, Multiple NA BeFree Detail
<0.001 Juvenile arthritis NA BeFree Detail
0.002 granulomatosis with polyangiitis NA GAD Detail
<0.001 Male Germ Cell Tumor NA BeFree Detail
<0.001 Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor NA BeFree Detail
0.002 Progressive cGVHD Combined MYC family amplifications and P53 pathway defects commonly emerged at r... BeFree 25533335 Detail
0.008 Triple Negative Breast Neoplasms The N+&C+ group was associated with larger tumor size, higher grade, negativity ... BeFree 24292333 Detail
0.008 Triple Negative Breast Neoplasms SOCS3-mediated regulation of inflammatory cytokines in PTEN and p53 inactivated ... BeFree 24531711 Detail
0.008 Triple Negative Breast Neoplasms Thymoquinone, a bioactive component of black caraway seeds, causes G1 phase cell... BeFree 24579801 Detail
0.008 Triple Negative Breast Neoplasms Only lymph node status was marginally significantly associated with poor prognos... BeFree 24945253 Detail
0.008 Triple Negative Breast Neoplasms Here, we used the high prevalence of TP53 mutations in triple negative breast ca... BeFree 25307450 Detail
0.008 Triple Negative Breast Neoplasms Combined deletion of Pten and p53 in mammary epithelium accelerates triple-negat... BeFree 25330770 Detail
0.008 Triple Negative Breast Neoplasms In the present study, we used recombinant human p53 adenovirus (Ad-p53) and EGFR... BeFree 25501339 Detail
0.008 Triple Negative Breast Neoplasms Primary mouse mammary epithelial cells (mMEC) with defined genetic features were... BeFree 25602521 Detail
0.008 Triple Negative Breast Neoplasms Results indicated that TNBC patients with a p53-positive tumor had a shorter rel... BeFree 25698149 Detail
0.008 Triple Negative Breast Neoplasms Gain-of-function mutations in TP53 are a frequent occurrence in TNBC and have be... BeFree 25788226 Detail
0.008 Triple Negative Breast Neoplasms Another highly important mutation can occur in TP53 resulting in a triple negati... BeFree 25824734 Detail
0.008 Triple Negative Breast Neoplasms Further, our data suggest that loss of the p53 tumor suppressor cooperates with ... BeFree 25870263 Detail
0.008 Triple Negative Breast Neoplasms The expression of p53 was higher in luminal B, HER2-enriched, and triple-negativ... BeFree 25966200 Detail
<0.001 Intracranial glioma NA BeFree Detail
<0.001 Melanocytic nevus of skin NA BeFree Detail
<0.001 Mammary adenocarcinoma NA BeFree Detail
<0.001 Noninvasive carcinoma ex pleomorphic adenoma NA BeFree Detail
0.049 Infection NA LHGDN Detail
<0.001 Fibromyxosarcoma NA BeFree Detail
0.001 Lymphoma, Diffuse NA BeFree Detail
<0.001 Pneumonitis NA BeFree Detail
0.080 Thymus Neoplasms NA CTD_mouse Detail
<0.001 RETINOSCHISIS 1, X-LINKED, JUVENILE NA BeFree Detail
0.003 intellectual disability NA BeFree,LHGDN Detail
<0.001 juvenile rheumatoid arthritis NA BeFree Detail
0.120 Leukemia, acute lymphoblastic, susceptibility to, 3 NA ORPHANET Detail
0.014 Experimental Organism Basal Cell Carcinoma Frequency and features of TP53 mutation in 30 Chinese patients with sporadic bas... BeFree 25196205 Detail
<0.001 Radiation Damage NA BeFree Detail
<0.001 Mesenchymal Glioblastoma NA BeFree Detail
0.003 High grade serous carcinoma Immunohistochemistry for IMP3 and p53 was performed and evaluated in 48 HGSCs wi... BeFree 25038792 Detail
0.003 High grade serous carcinoma High-grade serous carcinomas (HGSC) are TP53-mutated and are thought to be rarel... BeFree 25316818 Detail
0.003 High grade serous carcinoma TP53 mutations are the single most commonly identified mutations in aggressive s... BeFree 25473022 Detail
0.003 High grade serous carcinoma Knockdown of p53 in immortalized FTE cells and in four HGSC-derived cell lines e... BeFree 26206555 Detail
0.003 High grade serous carcinoma Ovulation is the strongest risk factor for ovarian high-grade serous carcinoma (... BeFree 26363031 Detail
<0.001 Abdominal Neoplasms NA BeFree Detail
0.001 Congenital Abnormality Moreover, the p53 protein is able to interact with both wild type Nkx2.5 and its... BeFree 25677450 Detail
0.002 Spontaneous abortion NA GAD Detail
0.007 Abortion, Habitual NA GAD Detail
0.006 acquired immunodeficiency syndrome NA BeFree,LHGDN Detail
<0.001 acromegaly An analysis of granulation patterns, MIB-1 proliferation indices and p53 express... BeFree 25238988 Detail
0.511 adenocarcinoma Overexpression of p53 was detected only in high-grade dysplasia and invasive ade... BeFree,CLINVAR,CTD_human,CTD_mouse,GAD,LHGDN 24603588 Detail
0.511 adenocarcinoma The authors show that combined loss of autophagy and p53 dramatically promotes p... BeFree,CLINVAR,CTD_human,CTD_mouse,GAD,LHGDN 24939064 Detail
0.511 adenocarcinoma False-negative controls consisted in microdissecting fresh-frozen tumor tissues ... BeFree,CLINVAR,CTD_human,CTD_mouse,GAD,LHGDN 25184754 Detail
0.511 adenocarcinoma Formalin Fixed Paraffin Embedded tissue were studied for miRNA expression, KRAS,... BeFree,CLINVAR,CTD_human,CTD_mouse,GAD,LHGDN 25496852 Detail
<0.001 adenofibroma NA BeFree Detail
0.179 adenoma These methylation epigenotypes, with specific genomic aberrations, are mostly co... BeFree,CTD_human,GAD,LHGDN 24962701 Detail
0.179 adenoma Chk2, phosphorylated Chk2 (pChk2), and TP53 were immunostained in 4 cases of ade... BeFree,CTD_human,GAD,LHGDN 25155618 Detail
0.179 adenoma Formalin Fixed Paraffin Embedded tissue were studied for miRNA expression, KRAS,... BeFree,CTD_human,GAD,LHGDN 25496852 Detail
<0.001 adenosarcoma NA BeFree Detail
0.001 Adenovirus Infections NA BeFree Detail
<0.001 Adrenal Gland Diseases NA BeFree Detail
0.123 Adrenal Gland Neoplasms NA BeFree,CTD_human Detail
<0.001 Primary myelofibrosis NA BeFree Detail
<0.001 agranulocytosis NA BeFree Detail
0.003 AIDS Dementia Complex NA LHGDN Detail
0.006 AIDS related complex NA BeFree,LHGDN Detail
<0.001 Albinism NA BeFree Detail
0.002 Alcoholic Intoxication, Chronic NA GAD Detail
0.018 Alzheimer's disease NA BeFree,GAD,LHGDN Detail
0.005 ameloblastoma Ameloblastic carcinoma developing in preexisting ameloblastoma with a mutation o... BeFree,GAD 24906942 Detail
0.122 amyotrophic lateral sclerosis We found that hTERT expression level was significantly lower in ALS patients and... BeFree,CTD_human 25142509 Detail
0.010 Anaplasia TP53 mutational status is a potential marker for risk stratification in Wilms tu... BeFree 25313908 Detail
0.010 Anaplasia TP53 mutations, which result in its overexpression, in combination with TERT pro... BeFree 25582503 Detail
0.010 Anaplasia Mechanistically, active mTORC1 is required to prevent a likely upregulation of t... BeFree 25853231 Detail
0.002 anemia Haploinsufficiency of ribosomal proteins (RPs) and upregulation of the tumour su... BeFree 25098371 Detail
0.004 aplastic anemia NA BeFree,LHGDN Detail
<0.001 Anemia, Macrocytic NA BeFree Detail
0.001 Refractory anemias NA BeFree Detail
<0.001 Refractory anaemia with excess blasts NA BeFree Detail
0.002 Aneuploidy NA GAD Detail
<0.001 Aneurysm NA BeFree Detail
<0.001 cutaneous fibrous histiocytoma NA BeFree Detail
0.014 Anoxia NA LHGDN Detail
0.003 Anus Neoplasms NA LHGDN Detail
<0.001 aortic valve insufficiency NA BeFree Detail
0.004 arteriosclerosis NA BeFree Detail
0.003 arthritis NA BeFree,GAD Detail
0.003 Arthritis, Psoriatic NA BeFree,GAD Detail
0.031 rheumatoid arthritis NA BeFree,GAD,LHGDN Detail
<0.001 asthma NA BeFree Detail
0.260 Astrocytoma The majority of astrocytomas harbor concurrent TP53 and ATRX mutations, while mo... BeFree,CLINVAR,CTD_mouse,GAD,LHGDN 25143301 Detail
0.260 Astrocytoma We found that oligoastrocytomas harbored mutations in TP53 (80%, 12/15) and ATRX... BeFree,CLINVAR,CTD_mouse,GAD,LHGDN 25257301 Detail
0.260 Astrocytoma In addition, p-CREB expression correlated with higher Ki-67 labeling index (P = ... BeFree,CLINVAR,CTD_mouse,GAD,LHGDN 25476123 Detail
0.260 Astrocytoma These findings suggest that CDKN2A testing may provide further clinical aid in l... BeFree,CLINVAR,CTD_mouse,GAD,LHGDN 25853694 Detail
<0.001 Ataxia NA BeFree Detail
0.014 ataxia telangiectasia NA BeFree Detail
0.006 atherosclerosis NA BeFree,GAD Detail
<0.001 Tooth Attrition NA BeFree Detail
0.003 autistic disorder NA BeFree,LHGDN Detail
0.005 Autoimmune Diseases Role of p53 in systemic autoimmune diseases. BeFree,GAD 25597313 Detail
0.126 Balkan nephropathy NA BeFree,CTD_human,GAD,LHGDN Detail
0.009 Barrett esophagus Immunostaining for p53 is the only candidate biomarker deemed ready for prime ti... BeFree,GAD,LHGDN 24844657 Detail
0.009 Barrett esophagus Aberrant TP53 detected by combining immunohistochemistry and DNA-FISH improves B... BeFree,GAD,LHGDN 25284618 Detail
0.009 Barrett esophagus Our analysis showed that oncogene amplification typically occurred as a late eve... BeFree,GAD,LHGDN 26192918 Detail
<0.001 Basal Cell Nevus Syndrome NA BeFree Detail
<0.001 Beckwith-Wiedemann syndrome NA BeFree Detail
0.001 Benign Ovarian Neoplasm NA BeFree Detail
0.002 bipolar disorder NA GAD Detail
0.121 Malignant neoplasm of urinary bladder Combined CDKN1A/TP53 mutation in bladder cancer is a therapeutic target. BeFree,GAD 25349305 Detail
0.121 Malignant neoplasm of urinary bladder Overall results suggest that phosphorylated HER3, ERK1/2 and p53 may be used as ... BeFree,GAD 25482142 Detail
0.121 Malignant neoplasm of urinary bladder Our findings confirm the alternative role of FGFR3 and TP53 mutations in the dev... BeFree,GAD 25537218 Detail
0.121 Malignant neoplasm of urinary bladder Recent developments in the field of molecular mutational pathway analyses based ... BeFree,GAD 25654736 Detail
0.121 Malignant neoplasm of urinary bladder Association of TP53 gene polymorphisms with susceptibility of bladder cancer in ... BeFree,GAD 25801242 Detail
0.264 Bladder Neoplasm NA BeFree,CTD_human,CTD_mouse,GAD,LHGDN Detail
0.010 Blast Phase NA BeFree Detail
0.002 Bloom syndrome NA BeFree Detail
0.080 Bone Diseases, Developmental NA CTD_mouse Detail
0.003 Bone neoplasms NA BeFree,GAD Detail
<0.001 borderline personality disorder NA BeFree Detail
0.166 Brain Neoplasms NA BeFree,CTD_mouse,GAD,LHGDN Detail
0.004 Breast Diseases NA BeFree,LHGDN Detail
<0.001 Brenner Tumor NA BeFree Detail
<0.001 Bronchial Neoplasms NA BeFree Detail
<0.001 bronchopulmonary dysplasia NA BeFree Detail
0.009 Burkitt lymphoma We identified TP53 mutations in MYC+/BCL2+ lymphomas at a frequency intermediate... BeFree,LHGDN 24679006 Detail
0.009 Burkitt lymphoma Reversion of apoptotic resistance of TP53-mutated Burkitt lymphoma B-cells to sp... BeFree,LHGDN 24787013 Detail
0.009 Burkitt lymphoma INZ(c) treatment decreased c-Myc expression at both mRNA and protein level, and ... BeFree,LHGDN 25692307 Detail
0.004 Carcinoid Tumor Although the status of RB1 and P53 between carcinoids and HGNETs were apparently... BeFree 25143124 Detail
0.002 female breast carcinoma Mutational profiling of familial male breast cancers reveals similarities with l... BeFree 25490678 Detail
0.006 Malignant neoplasm of larynx NA BeFree Detail
0.005 Adenocarcinoma of prostate NA BeFree Detail
0.010 Rectal Carcinoma NA BeFree Detail
0.025 Malignant neoplasm of skin We propose that the mutation of a single p53 allele provides a pro-oncogenic fun... BeFree 25789975 Detail
0.008 Malignant neoplasm of thyroid NA BeFree Detail
0.255 basal cell carcinoma NA CTD_human,GAD,GWASCAT,LHGDN Detail
0.002 Bronchioloalveolar Adenocarcinoma NA BeFree Detail
0.002 Bronchogenic Carcinoma NA BeFree Detail
0.012 Noninfiltrating Intraductal Carcinoma Somatic mutations or deletions of TP53 and PTEN in ductal carcinoma in situ lesi... BeFree,LHGDN 24531711 Detail
0.005 Merkel cell carcinoma NA BeFree,LHGDN Detail
0.010 mucinous adenocarcinoma Chk2, phosphorylated Chk2 (pChk2), and TP53 were immunostained in 4 cases of ade... BeFree,GAD,LHGDN 25155618 Detail
0.010 mucinous adenocarcinoma TP53 mutation occurred more frequently in carcinomas than borderline tumors (56.... BeFree,GAD,LHGDN 25986173 Detail
0.219 Non-small cell lung carcinoma These results suggest that intratumor genetic heterogeneity may be an important ... BeFree,CTD_human,GAD,LHGDN 24038464 Detail
0.219 Non-small cell lung carcinoma Our study indicates that the detection of the KRAS and p53 mutations in BAL flui... BeFree,CTD_human,GAD,LHGDN 24519547 Detail
0.219 Non-small cell lung carcinoma Nondisruptive p53 mutations are associated with shorter survival in patients wit... BeFree,CTD_human,GAD,LHGDN 24696321 Detail
0.219 Non-small cell lung carcinoma Mutations in TP53 are common in non-small cell lung cancer. BeFree,CTD_human,GAD,LHGDN 24916693 Detail
0.219 Non-small cell lung carcinoma This is a revised case report of a 52 year old Caucasian female with Li-Fraumeni... BeFree,CTD_human,GAD,LHGDN 25047674 Detail
0.219 Non-small cell lung carcinoma Promotion of p53 expression and reactive oxidative stress production is involved... BeFree,CTD_human,GAD,LHGDN 25220870 Detail
0.219 Non-small cell lung carcinoma SETDB1 positively stimulated activity of the WNT-β-catenin pathway and diminishe... BeFree,CTD_human,GAD,LHGDN 25404354 Detail
0.219 Non-small cell lung carcinoma Polymorphisms of p53 and MDM2 genes are associated with severe toxicities in pat... BeFree,CTD_human,GAD,LHGDN 25482940 Detail
0.219 Non-small cell lung carcinoma Genetic mutation of p53 and suppression of the miR-17∼92 cluster are synthetic l... BeFree,CTD_human,GAD,LHGDN 25519225 Detail
0.219 Non-small cell lung carcinoma In non-small cell lung cancer (NSCLC), both USP7 expression and p53 gene status ... BeFree,CTD_human,GAD,LHGDN 25519684 Detail
0.219 Non-small cell lung carcinoma USP22 promotes NSCLC tumorigenesis via MDMX up-regulation and subsequent p53 inh... BeFree,CTD_human,GAD,LHGDN 25547493 Detail
0.219 Non-small cell lung carcinoma Association of p53 and mdm2 in the development and progression of non-small cell... BeFree,CTD_human,GAD,LHGDN 25672611 Detail
0.219 Non-small cell lung carcinoma VEGF-A Expression Correlates with TP53 Mutations in Non-Small Cell Lung Cancer: ... BeFree,CTD_human,GAD,LHGDN 25672981 Detail
0.219 Non-small cell lung carcinoma Further experiments demonstrated that PANDAR expression was induced by p53, and ... BeFree,CTD_human,GAD,LHGDN 25719249 Detail
0.219 Non-small cell lung carcinoma We analyzed human non-small cell lung cancer (NSCLC) cell lines either wild type... BeFree,CTD_human,GAD,LHGDN 25796091 Detail
0.219 Non-small cell lung carcinoma Tumor-suppressive p53 Signaling Empowers Metastatic Inhibitor KLF17-dependent Tr... BeFree,CTD_human,GAD,LHGDN 25911104 Detail
0.015 Carcinoma, Papillary NA BeFree,GAD Detail
0.150 renal cell carcinoma We observed a good overall stability between primary RCC and corresponding xenog... BeFree,CTD_human,GAD,LHGDN 25031714 Detail
0.150 renal cell carcinoma Here, we show that apoptosis-resistant RCC cells have a disconnect between activ... BeFree,CTD_human,GAD,LHGDN 25499216 Detail
Annotation

Annotations

DescrptionSourceLinks
We also found significant inverse correlation between FGFR3 mutations and TP53 alterations in urothe... DisGeNET Detail
Taken together, our results provide evidence for RTK/RAS pathway activation and p53 deficiency as a ... DisGeNET Detail
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Specifically, 2 polymorphisms-an arginine-to-glutamine substitution at codon 399 (Q399R) in XRCC1 an... DisGeNET Detail
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Association between XRCC1 ARG399GLN and P53 ARG72PRO polymorphisms and the risk of gastric and color... DisGeNET Detail
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Association of a miR-502-binding site single nucleotide polymorphism in the 3'-untranslated region o... DisGeNET Detail
Several factors may contribute to cervical cancer (CC) development, including genetic variants such ... DisGeNET Detail
The p53 target gene WIG-1 (ZMAT3) is located in chromosomal region 3q26, that is frequently amplifie... DisGeNET Detail
Berberine alters epigenetic modifications, disrupts microtubule network, and modulates HPV-18 E6-E7 ... DisGeNET Detail
Thus, the polymorphism of p53 codon 72 in exon 4 does not seem to play a role in the development of ... DisGeNET Detail
Overexpression of Nm23H1 but not H2 also inhibited tumorigenesis by human cervical cancer HeLa cells... DisGeNET Detail
The mechanism and inhibitory effect of recombinant human P53 adenovirus injection combined with pacl... DisGeNET Detail
Therefore, we hypothesized that the genetic variants in these three genes influence the predispositi... DisGeNET Detail
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We have previously reported that the common, functionally different variants Arg72Pro in p53 and Arg... DisGeNET Detail
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We have previously reported that the common, functionally different variants Arg72Pro in p53 and Arg... DisGeNET Detail
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Here we showed first that in human IBD colonic samples and in murine colitis the LMα1 and LMα5 chain... DisGeNET Detail
Moreover, p53 is frequently mutated in the early stages of UC-associated cancer. DisGeNET Detail
Patients with UC with presence of extraintestinal manifestations, complications, and positive staini... DisGeNET Detail
TP53/p53 alterations and Aurora A expression in progressor and non-progressor colectomies from patie... DisGeNET Detail
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We have previously reported that the common, functionally different variants Arg72Pro in p53 and Arg... DisGeNET Detail
Therefore, we hypothesized that the genetic variants in these three genes influence the predispositi... DisGeNET Detail
Inactivation of TP53 pathway by TP53 mutations is observed in nearly half of colorectal tumors. DisGeNET Detail
Multiplex Ligation-dependent Probe Amplification, TP53 sequencing, real-time polymerase chain reacti... DisGeNET Detail
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We validated COLD-ddPCR on multiple mutations in TP53 and in EGFR using serial mutation dilutions an... DisGeNET Detail
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Association between XRCC1 ARG399GLN and P53 ARG72PRO polymorphisms and the risk of gastric and color... DisGeNET Detail
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The results suggested that the Arg399Gln polymorphism of XRCC1 gene, the 1G/2G polymorphism of MMP-1... DisGeNET Detail
Downregulation of p53 promotes in vitro perineural invasive activity of human salivary adenoid cysti... DisGeNET Detail
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These results uncover a new mechanism of p53 inactivation providing an interesting novel molecular l... DisGeNET Detail
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These results uncover a new mechanism of p53 inactivation providing an interesting novel molecular l... DisGeNET Detail
Reduced LRP6 expression and increase in the interaction of GSK3β with p53 contribute to podocyte apo... DisGeNET Detail
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In recent years, miR-1246 has been identified as a transcriptional target of p53 in Down syndrome an... DisGeNET Detail
Cell senescence was found to appear prematurely in DS cells as shown by SA-β-Gal assay and p21 asses... DisGeNET Detail
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Further, Cdh1(d/d)Trp53(d/d) tumors in 12-month-old mice were highly aggressive, and metastasized to... DisGeNET Detail
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pERK expression may have an impact on OS in erlotinib-treated patients with advanced pancreatic canc... DisGeNET Detail
Polysomy 7, polysomy 18, p16 deletion, and p53 deletion were significantly more frequent in invasive... DisGeNET Detail
More than 50% of human cancers contain a mutation or deletion of the p53 gene, and p53R175 is one of... DisGeNET Detail
Forty-two deleterious germline mutations were identified in 21 genes of 34 patients, including 18 (1... DisGeNET Detail
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She presented with a clinical diagnosis of Li-Fraumeni-like syndrome (LFL), showing papillary thyroi... DisGeNET Detail
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However, there is increased apoptosis in gastritis which may occur independent of H. pylori or p53 p... DisGeNET Detail
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Those tumors that lacked LOH 1p19q showed a high frequency of IDH1 mutations and loss of alpha thala... DisGeNET Detail
Due to the structural homology between p53 and p73, a subtle balance among p53 family members and th... DisGeNET Detail
A total of 157 diffuse gliomas (World Health Organization grades II-IV) were assessed by exon-by-exo... DisGeNET Detail
Furthermore, AND did not induce apoptosis or activate ERK and p53 in primary cultured astrocyte cell... DisGeNET Detail
Finally, p53 mutations correlated with alterations in ETC subunit composition and activity in primar... DisGeNET Detail
In support of the functional interaction between CD24 and p53, in silico analyses reveal that TP53 m... DisGeNET Detail
The effect of silibinin in enhancing toxicity of temozolomide and etoposide in p53 and PTEN-mutated ... DisGeNET Detail
Nearly all lower-grade gliomas with IDH mutations and no 1p/19q codeletion had mutations in TP53 (94... DisGeNET Detail
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ECCCs had SCA-like features with rare expression of estrogen receptor/progesterone receptor (18.8%/6... DisGeNET Detail
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One such example is hepatitis virus-induced liver cancer whereby p53 is inactivated upon the binding... DisGeNET Detail
One such example is hepatitis virus-induced liver cancer whereby p53 is inactivated upon the binding... DisGeNET Detail
Chronic infection with hepatitis B virus (HBV) and exposure to aflatoxin B1 (AFB1) induces p53 mutat... DisGeNET Detail
Finally, in HBV-related HCC, transcriptomic profiles were associated with specific gene mutations (H... DisGeNET Detail
Hepatitis B Virus Core Promoter A1762T/G1764A (TA)/T1753A/T1768A Mutations Contribute to Hepatocarci... DisGeNET Detail
Associations of mutations defined 3 groups of genes related to risk factors and centered on CTNNB1 (... DisGeNET Detail
Moreover, the HBV-MLL4 integration occurred almost exclusively in CTNNB1 and TP53 wild-type patients... DisGeNET Detail
Evaluation of CTNNB1 and TP53 variability in patients with hepatocellular carcinoma and occult hepat... DisGeNET Detail
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Results were correlated with immunoreactivity for USP7 (herpes virus-associated ubiquitin-specific p... DisGeNET Detail
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Uncommon non-oncogenic HPV genotypes, TP53 and MDM2 genes polymorphisms in HIV-infected women in Sou... DisGeNET Detail
Host restriction and associated viral latency have been studied for several decades. p53 has been su... DisGeNET Detail
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We assessed cellular manganese handling to test for correlations with the ATM-p53 pathway, and we ob... DisGeNET Detail
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Genetic depletion of Snail1 in MSCs that are deficient in p53 tumor suppressor downregulates MSC mar... DisGeNET Detail
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Here we showed first that in human IBD colonic samples and in murine colitis the LMα1 and LMα5 chain... DisGeNET Detail
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Induction of p21 independently of p53 is also observed in transgenic mice overexpressing HCaRG durin... DisGeNET Detail
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This study aimed to characterize the TP53 mutational spectrum in urothelial cancers consecutive to A... DisGeNET Detail
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Li-Fraumeni syndrome is caused by germline TP53 mutations and is clinically characterized by a predi... DisGeNET Detail
Lastly, we validate the effectiveness of ALX as a chemotherapeutic agent in vivo by demonstrating it... DisGeNET Detail
Expression of TP53 by CD34-positive cells was associated with shorter OS and leukaemia-free survival... DisGeNET Detail
The Role of TP53 Gene Codon 72 Polymorphism in Leukemia: A PRISMA-Compliant Systematic Review and Me... DisGeNET Detail
NOTCH1, SF3B1, BIRC3 and TP53 mutations in patients with chronic lymphocytic leukemia undergoing fir... DisGeNET Detail
Through the European Research Initiative on chronic lymphocytic leukemia (CLL) (ERIC), we screened 3... DisGeNET Detail
Sodium dichloroacetate exhibits anti-leukemic activity in B-chronic lymphocytic leukemia (B-CLL) and... DisGeNET Detail
Detailed analysis of therapy-driven clonal evolution of TP53 mutations in chronic lymphocytic leukem... DisGeNET Detail
From pioneering studies, we know that certain genetic events are found in the majority of chronic ly... DisGeNET Detail
We first performed detailed genetic analyses in a CLL cohort (n=110) containing ATM, SF3B1 and TP53 ... DisGeNET Detail
TP53 mutation analysis in chronic lymphocytic leukemia: comparison of different detection methods. DisGeNET Detail
TP53 codon 72 single nucleotide polymorphism in chronic lymphocytic leukemia. DisGeNET Detail
B-chronic lymphocytic leukemia (B-CLL) patients harboring p53 mutations are invariably refractory to... DisGeNET Detail
Ibrutinib for previously untreated and relapsed or refractory chronic lymphocytic leukaemia with TP5... DisGeNET Detail
The p53 transcriptional pathway is preserved in ATMmutated and NOTCH1mutated chronic lymphocytic leu... DisGeNET Detail
Frequencies of SF3B1, NOTCH1, MYD88, BIRC3 and IGHV mutations and TP53 disruptions in Chinese with c... DisGeNET Detail
TCL1 targeting miR-3676 is codeleted with tumor protein p53 in chronic lymphocytic leukemia. DisGeNET Detail
Allogeneic hematopoietic stem cell transplantation (alloHSCT) has been considered as the treatment o... DisGeNET Detail
Currently, these types of CLL are treated with approaches that do not target the p53 pathway, such a... DisGeNET Detail
In addition to miRNAs, the long non-coding RNAs (lncRNAs) nuclear enriched abundant transcript 1 (NE... DisGeNET Detail
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Strong p53 expression in ≥ 1% of bone marrow progenitor cells, observed in 35% (30 of 85) of patient... DisGeNET Detail
The regimen was active against patient-derived acute myelogenous leukemia (AML) cells harboring eith... DisGeNET Detail
Results confirm high frequencies of RAS and other activated signaling mutations (10/12 AMLs) and ide... DisGeNET Detail
MDM2 SNP309 and p53 codon 72 genetic polymorphisms and risk of AML: an Egyptian study. DisGeNET Detail
Role of TP53 mutations in the origin and evolution of therapy-related acute myeloid leukaemia. DisGeNET Detail
Consistent with these data, expression of JAK2V617F combined with Tp53 loss led to fully penetrant A... DisGeNET Detail
TP53 mutations are highly and similarly prevalent in t-MDS and t-AML but mutations in genes other th... DisGeNET Detail
Other mechanisms linked to PU.1 downregulation in human AML include TP53 deletion, FLT3-ITD mutation... DisGeNET Detail
Mutations in FLT3, DNMT3A, NRAS, NF1 and TP53 occur in persons of predominately European descent wit... DisGeNET Detail
TP53 mutation characteristics in therapy-related myelodysplastic syndromes and acute myeloid leukemi... DisGeNET Detail
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Indole-3-carbinol suppresses NF-κB activity and stimulates the p53 pathway in pre-B acute lymphoblas... DisGeNET Detail
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According to our results, the pharmacological inhibition of autophagy and p53 mutants are useful too... DisGeNET Detail
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An inverse correlation existed between miR-1228 and p53 expression in hepatoma tissues compared with... DisGeNET Detail
Tumorigenesis studies using an established liver tumor cell line confirmed a positive role of autoph... DisGeNET Detail
In addition, α-PA up-regulated nuclear p53 and down-regulated cytoplasmic p53 expression in J5 cells... DisGeNET Detail
Apoptosis of Bel-7402 human hepatoma cells induced by a ruthenium(II) complex coordinated by cordyce... DisGeNET Detail
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These findings suggest that HBEC apoptosis is increased in COPD, and that this involves p53 and casp... DisGeNET Detail
A total of 189 lung cancer patients were enrolled to determine nickel levels in tumor-adjacent norma... DisGeNET Detail
At the molecular level, reduced activation of ERK MAPK, but not Akt, was observed in lung tumours of... DisGeNET Detail
In this work, we found that PNAS-4 expression in lung tumor tissues is significantly lower than that... DisGeNET Detail
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In addition, the protein levels of p53 and alternative reading frame (ARF) were decreased in lymphom... DisGeNET Detail
Genomic studies of ALCL-11 showed the TP53 loss and the in vivo subclonal expansion of lymphoma cell... DisGeNET Detail
p53 is a well-known tumor suppressor.However, the regulatory mechanism(s) for p53 expression in B ly... DisGeNET Detail
Activation of p53 mediated glycolytic inhibition-oxidative stress-apoptosis pathway in Dalton's lymp... DisGeNET Detail
Molecular analysis of lymphomas revealed that arginine methylation of p53 selectively suppresses exp... DisGeNET Detail
We used isogenic lymphoma cell line models to prove p53 dependence of NEAT1 and lincRNA-p21. DisGeNET Detail
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PUMA protein in p53 regulatory molecule pattern determines the prognosis for patients with lymphopro... DisGeNET Detail
We report that persistent accumulation of DNA damage/strand breaks and chronic activation of the ser... DisGeNET Detail
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Whilst drugs directly targeting SIRT1, were potent to trigger cell death at high concentrations only... DisGeNET Detail
Combined MYC and P53 defects emerge at medulloblastoma relapse and define rapidly progressive, thera... DisGeNET Detail
WNT activation by lithium abrogates TP53 mutation associated radiation resistance in medulloblastoma... DisGeNET Detail
Treatment of Med in Ptch1(+/-) Trp53(-/-) mice with the antiestrogen chemotherapeutic drug Faslodex ... DisGeNET Detail
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To understand the phenotypic similarities/differences between lung carcinoids and HGNETs, we compara... DisGeNET Detail
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These results uncover a new mechanism of p53 inactivation providing an interesting novel molecular l... DisGeNET Detail
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In addition, we tested if Hsp27 protein levels correlated with p53 expression and cell proliferation... DisGeNET Detail
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The expression of nine of them is higher in MM plasma cells than in healthy donor counterparts, sugg... DisGeNET Detail
Moreover, silencing of p53 in two TP53(mutated) cell lines failed to inhibit apoptosis that was indu... DisGeNET Detail
This review summarizes different modes of p53 inactivation in myeloma and highlights the current p53... DisGeNET Detail
ANKHD1 downregulation modulates cell cycle gene expression and upregulates p21 irrespective of the T... DisGeNET Detail
Features of extramedullary disease of multiple myeloma: high frequency of p53 deletion and poor surv... DisGeNET Detail
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Additionally, the mutation data identified 2 other potential contributing factors to MF, ultraviolet... DisGeNET Detail
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We performed genomic profiling of post-MPN AML samples; these studies demonstrate somatic tumor prot... DisGeNET Detail
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Almost all identified high-penetrance gene mutations in those families fulfill the typical phenotype... DisGeNET Detail
A significant percentage (5-10%) of pediatric cancers are associated with hereditary cancer syndrome... DisGeNET Detail
TP53 mutational status is a potential marker for risk stratification in Wilms tumour with diffuse an... DisGeNET Detail
We show that (i) in the choroid plexus carcinoma, the germline mutation was detected in a homozygous... DisGeNET Detail
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Exome DNA sequencing of blood samples from a Li-Fraumeni family with a TP53 germline mutation (codon... DisGeNET Detail
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Two family members without a TP53 germline mutation who developed peripheral schwannomas also carrie... DisGeNET Detail
Here we investigated p53 regulation and its role in proliferation and survival of human primary schw... DisGeNET Detail
CFM-1, -4, and -5 inhibited NB cell growth, in vitro, independent of their p53 and MYCN status. DisGeNET Detail
Simultaneous Adrenocortical Carcinoma and Neuroblastoma in an Infant With a Novel Germline p53 Mutat... DisGeNET Detail
Of note, less than 2% of neuroblastoma tumors have a TP53 mutation at diagnosis. DisGeNET Detail
Treatment of wild-type TP53 neuroblastoma cell lines with both GSK2830371 and either doxorubicin or ... DisGeNET Detail
Genome wide expression profiling of p53 regulated miRNAs in neuroblastoma. DisGeNET Detail
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The most common predisposition syndromes include germline TP53 mutations and constitutive alteration... DisGeNET Detail
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The whitish nodule corresponded to the sarcomatoid component, and the spindled and pleomorphic tumor... DisGeNET Detail
Inhibition of endothelial p53 improves metabolic abnormalities related to dietary obesity. DisGeNET Detail
These results uncover a new mechanism of p53 inactivation providing an interesting novel molecular l... DisGeNET Detail
Prostaglandin E2 inhibits p53 in human breast adipose stromal cells: a novel mechanism for the regul... DisGeNET Detail
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Those tumors that lacked LOH 1p19q showed a high frequency of IDH1 mutations and loss of alpha thala... DisGeNET Detail
The mean of Olig2 LI of gliomas with 1p/19q loss ± IDH1/2 mutation, the majority of them being oligo... DisGeNET Detail
We found that oligoastrocytomas harbored mutations in TP53 (80%, 12/15) and ATRX (60%, 9/15) at freq... DisGeNET Detail
The TP53 and HIST1H3A genes were the hub nodes in the PPI network of DEGs from GBM, while CNTN2 was ... DisGeNET Detail
Thus, we analyzed the expression of p-CREB in a series of astrocytomas and oligodendrogliomas of dif... DisGeNET Detail
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Overexpression of RASSF5 markedly suppressed cell proliferation and invasion, and induced cell apopt... DisGeNET Detail
Prognostic value of p53 alterations in human osteosarcoma: a meta analysis. DisGeNET Detail
p53-dependent activation of microRNA-34a in response to etoposide-induced DNA damage in osteosarcoma... DisGeNET Detail
Inactivation of p53 and/or Rb pathways restrains osteoblasts from cell-cycle exit and terminal diffe... DisGeNET Detail
Here, we established patient-derived iPSCs from a Li-Fraumeni syndrome (LFS) family and investigated... DisGeNET Detail
Germline TP53 variants and susceptibility to osteosarcoma. DisGeNET Detail
To identify the genes driving osteosarcoma development and metastasis, we performed a Sleeping Beaut... DisGeNET Detail
Mutation or loss of p53 differentially modifies TGFβ action in ovarian cancer. DisGeNET Detail
In this study, the nuclear expression levels of γ-H2AX and p53 using immunohistochemical (IHC) study... DisGeNET Detail
Selective tumor cell killing by triptolide in p53 wild-type and p53 mutant ovarian carcinomas. DisGeNET Detail
Association between a single nucleotide polymorphism in the TP53 region and risk of ovarian cancer. DisGeNET Detail
The observed upregulation of pro-apoptotic genes and apoptosis in cancer cells without p53 in respon... DisGeNET Detail
We demonstrated that in a unique population of HGSOC cancer cells with cancer stem cell properties, ... DisGeNET Detail
Genomic classification of serous ovarian cancer with adjacent borderline differentiates RAS pathway ... DisGeNET Detail
TP53 oncomorphic mutations predict resistance to platinum‑ and taxane‑based standard chemotherapy in... DisGeNET Detail
TP53 remains as the most frequently altered gene in high grade serous ovarian cancer and Ion Torrent... DisGeNET Detail
Detection of somatic TP53 mutations in tampons of patients with high-grade serous ovarian cancer. DisGeNET Detail
Molecular characterization of an intact p53 pathway subtype in high-grade serous ovarian cancer. DisGeNET Detail
Although the effect of new drugs such as poly(ADP-ribose) polymerase inhibitors are being investigat... DisGeNET Detail
Co-immunoprecipitation and western blotting showed significantly lower levels of p53 and p53 Ser15-p... DisGeNET Detail
The present study aimed to clarify the role of PLK1, P53 and P21WAF1 in the prognosis of ovarian can... DisGeNET Detail
CR389, a benzoimidazolyl pyridinone analog, induces cell cycle arrest and apoptosis via p53 activati... DisGeNET Detail
Overall, FBN1, acts at the downstream of Aur A and BRCA2, promotes ovarian cancer metastasis through... DisGeNET Detail
First, we observed the upregulation protein level of p53 target genes in cisplatin-resistant or cisp... DisGeNET Detail
There is a link between miR-7 expression and TP53 status and tumour grade in serous OC. DisGeNET Detail
TP53 hot spot mutations in ovarian cancer: selective resistance to microtubule stabilizers in vitro ... DisGeNET Detail
We propose that this unique ability of APR-246/MQ to bind to cysteines in both mutant p53 and glutat... DisGeNET Detail
The study found a high expression of P53 (64%) and MIB1 (72%) and an expression of BCL2 (48%) in asc... DisGeNET Detail
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Autophagy is critical for pancreatic tumor growth and progression in tumors with p53 alterations. DisGeNET Detail
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CD24 silencing prevents functional inactivation of p53 by both somatic mutation and viral oncogenes,... DisGeNET Detail
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In Wild-type (WT) mice with passive CSE (PCSE), p53 and PAI-1 expression and apoptosis were increase... DisGeNET Detail
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Moreover, inhibition of p53 in PV erythroblasts resulted in more gamma-H2Ax (γ-H2Ax)-marked double-s... DisGeNET Detail
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Met was amplified in 67% of prostate tumors from Pten p53 prostate conditional null mice and in appr... DisGeNET Detail
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Elevated p57Kip2 induces G1/S phase cell cycle arrest but inhibits cell death in response to DNA dam... DisGeNET Detail
Proteins encoded by CDK2, TP53, and RELA have been associated with the progression of renal failure ... DisGeNET Detail
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In the current study, genetically engineered mice were generated to determine the role of Rb and p53... DisGeNET Detail
In addition, loss-of-function mutations in p53 (TP53) as well as deleterious mutations in the tumor ... DisGeNET Detail
Following further examination of cell cycle-related factors, MCM2 knockdown inhibited protein retino... DisGeNET Detail
It is unique among the epithelial carcinomas as two distinct pathways to tumourigenesis appear to ex... DisGeNET Detail
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The purpose of the present study was to investigate the role of sirtuin expression, activity and inh... DisGeNET Detail
We also demonstrate that miR-605 overexpression leads to a decrease in cell proliferation, clonogeni... DisGeNET Detail
Kaposi's sarcoma-associated herpesvirus (KSHV)-related malignancies express wild-type p53. DisGeNET Detail
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MicroRNA-125b inhibits lens epithelial cell apoptosis by targeting p53 in age-related cataract. DisGeNET Detail
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The detection limits for analyzing the Smallpox and TP53 genes correspond to 0.1 nM. DisGeNET Detail
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Three other genes, TP53, EP300 and CALM1 might also contribute to the pathogenesis of PTSD since the... DisGeNET Detail
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The purpose of the present study was to investigate the role of sirtuin expression, activity and inh... DisGeNET Detail
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A mutation screening of oncogenes, tumor suppressor gene TP53 and nuclear encoded mitochondrial comp... DisGeNET Detail
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Genomic profile of a Li-Fraumeni-like syndrome patient with a 45,X/46,XX karyotype, presenting neith... DisGeNET Detail
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To address the unmet need, we recently developed RapidCaP mice, which endogenously recreate human PT... DisGeNET Detail
Evaluation of CTNNB1 and TP53 variability in patients with hepatocellular carcinoma and occult hepat... DisGeNET Detail
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Erythroblasts negative for WRN immunostaining were only observed in two patients, both of whom were ... DisGeNET Detail
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TP53 mutations are frequent events in double-hit B-cell lymphomas with MYC and BCL2 but not MYC and ... DisGeNET Detail
Reversion of apoptotic resistance of TP53-mutated Burkitt lymphoma B-cells to spindle poisons by exo... DisGeNET Detail
MicroRNA-124 links p53 to the NF-κB pathway in B-cell lymphomas. DisGeNET Detail
Consequently, miR-200-induced T2D is suppressed by interfering with the signaling of Trp53 and Bax, ... DisGeNET Detail
Mechanistically, 4-MU led to increased p53 mRNA expression, elevated cytoplasmic protein levels of c... DisGeNET Detail
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These alterations were accompanied by increased forkhead box O3 (FoxO3) in several cell lines and in... DisGeNET Detail
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Our meta-analysis demonstrates that TP53 codon 72 polymorphism may not be a risk factor for acute le... DisGeNET Detail
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We found that resistance to spindle poison-induced apoptosis could be reverted in tumor protein p53 ... DisGeNET Detail
In the presented studies p53 and bcl-2 proteins expression were evaluated in samples of gastric carc... DisGeNET Detail
In non-small cell lung cancer (NSCLC), both USP7 expression and p53 gene status were reported to be ... DisGeNET Detail
Correlation between squamous cell carcinoma of the lung and human papillomavirus infection and the r... DisGeNET Detail
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The PTEN/PIK3CA pathway was interrogated using an AdenoCre-driven mouse model of SCLC harboring inac... DisGeNET Detail
In comparison to the carcinoids, LCNEC/SCLC tumors presented a stronger loss of nuclear and cytosoli... DisGeNET Detail
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Mutation of TP53 and alteration of p14(arf) expression in EGFR- and KRAS-mutated lung adenocarcinoma... DisGeNET Detail
LATS2 mRNA level was found to be a significant independent predictor for survival status (disease-fr... DisGeNET Detail
Proteomic signatures associated with p53 mutational status in lung adenocarcinoma. DisGeNET Detail
PBK/TOPK expression correlates with mutant p53 and affects patients' prognosis and cell proliferatio... DisGeNET Detail
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TP53 Pro72 allele is enriched in oral tongue cancer and frequently mutated in esophageal cancer in I... DisGeNET Detail
The increased expression of pS(21)GSK3α and pS(9)GSK3β not only correlated positively with cyclin D1... DisGeNET Detail
Phenethyl isothiocyanate induces DNA damage-associated G2/M arrest and subsequent apoptosis in oral ... DisGeNET Detail
The detection limits, established as 3σ, were estimated to be 0.03 and 0.06 fmol L(-1) for the p53 a... DisGeNET Detail
The expression of total and phosphorylated GSK3α/β as well as cyclin D1 and p53 together with their ... DisGeNET Detail
Among these biomarkers, p53 is the strongest prognostic marker in OPC and p53 in addition to p16 sup... DisGeNET Detail
The biology of HPV-positive oropharyngeal cancer is distinct; it includes p53 degradation, retinobla... DisGeNET Detail
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High frequency of TP53 but not K-ras gene mutations in Bolivian patients with gallbladder cancer. DisGeNET Detail
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Alternative lengthening of telomeres is enriched in, and impacts survival of TP53 mutant pediatric m... DisGeNET Detail
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Our study, for the first time, demonstrates that GINS2 is an independent prognostic marker and is as... DisGeNET Detail
Interestingly, the combined silencing of p53 and Toca-1 led to a partial rescue of these effects of ... DisGeNET Detail
Tumor cells expressing high-risk TP53 mutations were more invasive and tumorigenic and they exhibite... DisGeNET Detail
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Autophagy is upregulated in ovarian endometriosis: a possible interplay with p53 and heme oxygenase-... DisGeNET Detail
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Somatic mutations in ACC-associated genes included TP53 (8/41 tumors, 19.5%) and CTNNB1 (4/41, 9.8%)... DisGeNET Detail
TP53 mutations are prevalent in children with ACC but decline with age. DisGeNET Detail
The TP53 mutation detection rate in children presenting with ACC or choroid plexus carcinomas, and i... DisGeNET Detail
On the contrary, p53 loss led to increased apoptosis that had to be overcome for tumor progression. DisGeNET Detail
Altered p53 regulation of miR-148b and p55PIK contributes to tumor progression in colorectal cancer. DisGeNET Detail
This study provides the first time evidence that RRM2B is transcriptionally and functionally regulat... DisGeNET Detail
It is therefore important to elucidate the role of these downstream targets in p53 regulated tumor p... DisGeNET Detail
These findings are relevant to human basal-like tumor progression in vivo, since miR-146a is highly ... DisGeNET Detail
These results uncover a new mechanism of p53 inactivation providing an interesting novel molecular l... DisGeNET Detail
Moreover, by two-dimensional gel electrophoresis and mass spectrometry we discovered that the aggreg... DisGeNET Detail
Emerging from the shade of p53 mutants: N-terminally truncated variants of the p53 family in EMT sig... DisGeNET Detail
The p53 and NFκB sequence-specific transcription factors play crucial roles in cell proliferation an... DisGeNET Detail
Many cancers express mutant p53 proteins that have lost wild-type tumor suppressor activity and, in ... DisGeNET Detail
These results suggest that stroma-derived p53 plays a pivotal role in epithelial cancer progression ... DisGeNET Detail
However, the presence of p53 mutations in skin premalignant lesions suggests that these represent ea... DisGeNET Detail
The 14-3-3ζ-driven contextual changes of Smad partners from p53 to Gli2 may serve as biomarkers and ... DisGeNET Detail
The p53 family and the hypoxia-inducible factors (HIFs): determinants of cancer progression. DisGeNET Detail
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Massively parallel sequencing identifies recurrent mutations in TP53 in thymic carcinoma associated ... DisGeNET Detail
TP53 was the most frequently mutated gene in TETs (n = 13; 17%), especially in TCs (26%), and was as... DisGeNET Detail
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Genomic studies of ALCL-11 showed the TP53 loss and the in vivo subclonal expansion of lymphoma cell... DisGeNET Detail
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UV-independent p53 mutations in sebaceous carcinoma of the eyelid. DisGeNET Detail
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ECCCs had SCA-like features with rare expression of estrogen receptor/progesterone receptor (18.8%/6... DisGeNET Detail
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A missense mutation in TP53 exon 7 (c.734G>C) and strong nuclear immunostaining for p53 were detecte... DisGeNET Detail
CCA with Ov shows significantly higher incidence of the TP53 gene mutation, whereas CCA without Ov s... DisGeNET Detail
Interestingly, there is a significant difference in the frequency of mutated genes between Ov-relate... DisGeNET Detail
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The overall mutation profile of this cohort of endometrial CCC appears to be more serous-like than e... DisGeNET Detail
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In non-small cell lung cancer (NSCLC), both USP7 expression and p53 gene status were reported to be ... DisGeNET Detail
Diffuse p16 expression was associated with younger age at presentation (P<0.0001), basaloid and wart... DisGeNET Detail
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No variation of p16, p21, PLUNC (palate, lung, and nasal epithelium clone protein) and p53 expressio... DisGeNET Detail
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Genetic alterations in human cancers and murine models indicate that retinoblastoma (Rb) and p53 hav... DisGeNET Detail
The p53 network as therapeutic target in gastroenteropancreatic neuroendocrine neoplasms. DisGeNET Detail
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Interestingly, ALT attenuated the poor outcome conferred by TP53 mutations in specific pediatric bra... DisGeNET Detail
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Phenethyl isothiocyanate induces DNA damage-associated G2/M arrest and subsequent apoptosis in oral ... DisGeNET Detail
The detection limits, established as 3σ, were estimated to be 0.03 and 0.06 fmol L(-1) for the p53 a... DisGeNET Detail
The expression of total and phosphorylated GSK3α/β as well as cyclin D1 and p53 together with their ... DisGeNET Detail
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Mutational profiling of familial male breast cancers reveals similarities with luminal A female brea... DisGeNET Detail
High frequency of TP53 but not K-ras gene mutations in Bolivian patients with gallbladder cancer. DisGeNET Detail
All MSI tumors were negative for HER2 amplification, and TP53 and NRAS mutations were only found in ... DisGeNET Detail
Other genetic alterations, including telomere shortening and the inactivation of tumor suppressor ge... DisGeNET Detail
Taken together, our data indicate that PRIMA-1 induces apoptosis in p53 mutant pancreatic cancer cel... DisGeNET Detail
Together, our data support the critical role of autophagy in pancreatic cancer and show that inhibit... DisGeNET Detail
Studies of the molecular pathology of pancreatic cancer have revealed that activation of KRAS, overe... DisGeNET Detail
pERK, pAKT and p53 as tissue biomarkers in erlotinib-treated patients with advanced pancreatic cance... DisGeNET Detail
We investigated the prevalence of germline mutations in APC, ATM, BRCA1, BRCA2, CDKN2A, MLH1, MSH2, ... DisGeNET Detail
Chromosomal rearrangements leading to gene disruption were prevalent, affecting genes known to be im... DisGeNET Detail
Therapeutic Targeting of the Warburg Effect in Pancreatic Cancer Relies on an Absence of p53 Functio... DisGeNET Detail
Here we report a systematic definition of how pancreatic cancer cells harboring mutant p53 respond t... DisGeNET Detail
Enhanced phosphorylation of p53 by microRNA-26a leading to growth inhibition of pancreatic cancer. DisGeNET Detail
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Epigenetic silencing of miR-218 is a common feature in HR-HPV(+) PSCCs and in HR-HPV(-) PSCCs withou... DisGeNET Detail
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In the current study, genetically engineered mice were generated to determine the role of Rb and p53... DisGeNET Detail
By simultaneously activating Kras and deleting p53 (Trp53) in thyroid follicular cells, we have gene... DisGeNET Detail
In immunohistochemical studies, DSVPTC showed different expression patterns of epithelial membrane a... DisGeNET Detail
Pri-Mir-34b/C and Tp-53 Polymorphisms are Associated With The Susceptibility of Papillary Thyroid Ca... DisGeNET Detail
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Ectopic expression of miR-506 inhibits NF-κB p65 expression, induces ROS accumulation and then activ... DisGeNET Detail
Nickel accumulation in lung tissues is associated with increased risk of p53 mutation in lung cancer... DisGeNET Detail
Rapamycin prevents strong phosphorylation of p53 on serine 46 and attenuates activation of the p53 p... DisGeNET Detail
TP53 mutations and lung cancer: not all mutations are created equal. DisGeNET Detail
Caveolin-1 regulates lung cancer stem-like cell induction and p53 inactivation in carbon nanotube-dr... DisGeNET Detail
AP-2α downregulation by cigarette smoke condensate is counteracted by p53 in human lung cancer cells... DisGeNET Detail
β-Elemene against human lung cancer via up-regulation of P53 protein expression to promote the relea... DisGeNET Detail
We evaluated 23 single nucleotide polymorphisms (SNPs) in the five nicotinic receptor related genes ... DisGeNET Detail
Evaluation of the mutagenicity of anti-B[a]P-diol epoxide with B[a]P-7,8-dione on p53 showed that th... DisGeNET Detail
Loss of p53 function may result in upregulation of 14-3-3γ in lung cancers. DisGeNET Detail
In addition, we used lung cancer cell lines with different p53 gene background (p53 null and p53 wil... DisGeNET Detail
Finally, we provide an analysis of discerning epidemiological data obtained from the IARC database a... DisGeNET Detail
SOX30, a novel epigenetic silenced tumor suppressor, promotes tumor cell apoptosis by transcriptiona... DisGeNET Detail
Moreover, co-treatment of MML and p53 inhibitor would be more effective in human lung cancer therapy... DisGeNET Detail
Thus, we conclude that p53 deficiency and KRAS mutation activate the NF-κB signaling to control chem... DisGeNET Detail
Our finding supports that mir-660 acts as a tumor suppressor miRNA and we suggest the replacement of... DisGeNET Detail
These results suggest that stroma-derived p53 plays a pivotal role in epithelial cancer progression ... DisGeNET Detail
Association of a p53 codon 72 gene polymorphism with environmental factors and risk of lung cancer: ... DisGeNET Detail
We identified mutations in both tumors, including KEAP1 (commonly mutated in lung cancers) in one, a... DisGeNET Detail
Treatment of cells with curcumin induced both p53 and the related protein p73 in head and neck and l... DisGeNET Detail
TP53 Codon 72 Polymorphisms and Lung Cancer Risk in the Bangladeshi Population. DisGeNET Detail
Furthermore, using data generated by The Cancer Genome Atlas consortium, we demonstrate that the eff... DisGeNET Detail
These results demonstrate that p53 is able to respond to exposure of arsenic or Cr(VI), suggesting t... DisGeNET Detail
However, p53-targeted therapies have limited application in lung cancer, since p53 is found to be mu... DisGeNET Detail
This RNA aptamer (p53R175H-APT) has a significantly stronger affinity to p53R175H than to the wild-t... DisGeNET Detail
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With regards to overall survival, factors predictive of an unfavorable outcome were minimal residual... DisGeNET Detail
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The inability of mice to develop HCC when autophagy was impaired was associated with the induction o... DisGeNET Detail
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The pathogenesis of prostatic SCNC involves a p53 and Aurora Kinase A signaling mechanism, both pote... DisGeNET Detail
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TP53 overexpression is a predictor of poor outcome in patients with MDS-F. DisGeNET Detail
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Together, the results of this study support PARN as a DC-associated gene and suggest a potential lin... DisGeNET Detail
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Moreover, a significant decrease of p53 protein and a significant increase of heme oxygenase-1 prote... DisGeNET Detail
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Functional TP53 mutations have no impact on response to cytotoxic agents in metastatic colon cancer. DisGeNET Detail
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Furthermore a minimal IBC-related predictive set of 4 miRNAs associated with the TP53 mutational sta... DisGeNET Detail
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The obtained results allow the conclusion, that H. pylori (cagA+)-associated development of the gast... DisGeNET Detail
A significant percentage (5-10%) of pediatric cancers are associated with hereditary cancer syndrome... DisGeNET Detail
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We investigated the safety and activity of ibrutinib in previously untreated and relapsed or refract... DisGeNET Detail
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Phase I dendritic cell p53 peptide vaccine for head and neck cancer. DisGeNET Detail
TP53 is the most commonly mutated gene in head and neck cancer (HNSCC), with mutations being associa... DisGeNET Detail
Anomalous altered expressions of downstream gene-targets in TP53-miRNA pathways in head and neck can... DisGeNET Detail
Wee-1 kinase inhibition overcomes cisplatin resistance associated with high-risk TP53 mutations in h... DisGeNET Detail
Salivary adenoid cystic carcinoma (SACC) is a malignant tumor that is characterized by perineural in... DisGeNET Detail
Evolutionary Action Score of TP53 Identifies High-Risk Mutations Associated with Decreased Survival ... DisGeNET Detail
Evolutionary Action Score of TP53 Coding Variants Is Predictive of Platinum Response in Head and Nec... DisGeNET Detail
The role of HPV RNA transcription, immune response-related gene expression and disruptive TP53 mutat... DisGeNET Detail
One such example is hepatitis virus-induced liver cancer whereby p53 is inactivated upon the binding... DisGeNET Detail
NUMB phosphorylation destabilizes p53 and promotes self-renewal of tumor-initiating cells by a NANOG... DisGeNET Detail
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Association between SNPs in P53 binding regions and risk of esophageal squamous cell carcinoma. DisGeNET Detail
LINE-1 hypomethylation of ESCC was significantly associated with lymph node metastasis, lymphovascul... DisGeNET Detail
Combined effects of leukocyte telomere length, p53 polymorphism and human papillomavirus infection o... DisGeNET Detail
Esophageal cells overexpressing epidermal growth factor receptor (EGFR) and TP53 mutation can invade... DisGeNET Detail
These findings identify an important subgroup of young patients with cancer who carry germline mutat... DisGeNET Detail
Database of mutations in the p53 and APC tumor suppressor genes designed to facilitate molecular epi... DisGeNET Detail
Combining the techniques detected TP53 abnormalities in 100% of patients with LGD, HGD, and EAC. DisGeNET Detail
Barrett's esophagus is thought to progress to esophageal adenocarcinoma (EAC) through a stepwise pro... DisGeNET Detail
p53 mutations in human cancers. DisGeNET Detail
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Expression of cell cycle-related proteins, p16, p53 and p63 as important prognostic markers in gallb... DisGeNET Detail
To investigate protein expression and mutations in phosphatase and tensin homolog (PTEN) in patients... DisGeNET Detail
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The expression patterns of p53 and p16 and an analysis of a possible role of HPV in primary adenocar... DisGeNET Detail
Ubiquitin E3 ligase UHRF1 regulates p53 ubiquitination and p53-dependent cell apoptosis in clear cel... DisGeNET Detail
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These studies showed that TP53 and PI3KCA are the two most mutated genes in all types of cancers and... DisGeNET Detail
The human cervical cancer oncogene (HCCR) has been shown to be over-expressed in some solid tumors, ... DisGeNET Detail
Genetic deletion of the telomerase subunit Terc in a retroviral mouse AML model induces cell-cycle a... DisGeNET Detail
The influence of TP53 mutations on the prognosis of patients with early stage non-small cell lung ca... DisGeNET Detail
TP53 mutations in early-stage non-small cell lung cancer (NSCLC) may be associated with worse surviv... DisGeNET Detail
Prognostic value of ERCC1, ERCC2, XRCC1, and TP53 single nucleotide polymorphisms in patients with e... DisGeNET Detail
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Exome sequencing showed that OVC samples lacked mutations in genes commonly associated with OSCC (TP... DisGeNET Detail
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We show that (i) in the choroid plexus carcinoma, the germline mutation was detected in a homozygous... DisGeNET Detail
TP53 overexpression is an independent adverse prognostic factor in de novo myelodysplastic syndromes... DisGeNET Detail
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In all but one OA the combination of nuclear p53 accumulation and ATRX loss was mutually exclusive w... DisGeNET Detail
We found that oligoastrocytomas harbored mutations in TP53 (80%, 12/15) and ATRX (60%, 9/15) at freq... DisGeNET Detail
As most studies have focused on HPV infection and TP53 mutations, we suggest that more research shou... DisGeNET Detail
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TP53 mutation is a common event in many cancers, including pancreatic adenocarcinoma, where it occur... DisGeNET Detail
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Positive staining for p53 was observed in 15 (24.59%) cases of cervical intraepithelial neoplasia an... DisGeNET Detail
Association of a miR-502-binding site single nucleotide polymorphism in the 3'-untranslated region o... DisGeNET Detail
Several factors may contribute to cervical cancer (CC) development, including genetic variants such ... DisGeNET Detail
Msi1 promotes tumor growth and cell proliferation by targeting cell cycle checkpoint proteins p21, p... DisGeNET Detail
Expression of the p53 target Wig-1 is associated with HPV status and patient survival in cervical ca... DisGeNET Detail
Berberine alters epigenetic modifications, disrupts microtubule network, and modulates HPV-18 E6-E7 ... DisGeNET Detail
The preliminary study of p53 codon 72 polymorphism and risk of cervical carcinoma in Gabonese women. DisGeNET Detail
Overexpression of Nm23H1 but not H2 also inhibited tumorigenesis by human cervical cancer HeLa cells... DisGeNET Detail
The mechanism and inhibitory effect of recombinant human P53 adenovirus injection combined with pacl... DisGeNET Detail
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Formalin Fixed Paraffin Embedded tissue were studied for miRNA expression, KRAS, BRAF, PIK3CA mutati... DisGeNET Detail
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Although the status of RB1 and P53 between carcinoids and HGNETs were apparently different, the DNTF... DisGeNET Detail
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TP53 mutation occurred more frequently in carcinomas than borderline tumors (56.8 % and 11.5 %, resp... DisGeNET Detail
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Those tumors that lacked LOH 1p19q showed a high frequency of IDH1 mutations and loss of alpha thala... DisGeNET Detail
The mean of Olig2 LI of gliomas with 1p/19q loss ± IDH1/2 mutation, the majority of them being oligo... DisGeNET Detail
We found that oligoastrocytomas harbored mutations in TP53 (80%, 12/15) and ATRX (60%, 9/15) at freq... DisGeNET Detail
The TP53 and HIST1H3A genes were the hub nodes in the PPI network of DEGs from GBM, while CNTN2 was ... DisGeNET Detail
Thus, we analyzed the expression of p-CREB in a series of astrocytomas and oligodendrogliomas of dif... DisGeNET Detail
We find evidence of regional mutational heterogeneity in multiple tumors, including mutations in TP5... DisGeNET Detail
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Progressive leukemic non-nodal mantle cell lymphoma associated with deletions of TP53, ATM, and/or 1... DisGeNET Detail
High-dose cytarabine does not overcome the adverse prognostic value of CDKN2A and TP53 deletions in ... DisGeNET Detail
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Combined effects of leukocyte telomere length, p53 polymorphism and human papillomavirus infection o... DisGeNET Detail
Correlation between squamous cell carcinoma of the lung and human papillomavirus infection and the r... DisGeNET Detail
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One such example is hepatitis virus-induced liver cancer whereby p53 is inactivated upon the binding... DisGeNET Detail
NUMB phosphorylation destabilizes p53 and promotes self-renewal of tumor-initiating cells by a NANOG... DisGeNET Detail
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However, only about 20% of familial breast cancer is attributed to mutations in BRCA1 and BRCA2, whi... DisGeNET Detail
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Diffuse p16 expression was associated with younger age at presentation (P<0.0001), basaloid and wart... DisGeNET Detail
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Other genetic alterations, including telomere shortening and the inactivation of tumor suppressor ge... DisGeNET Detail
Taken together, our data indicate that PRIMA-1 induces apoptosis in p53 mutant pancreatic cancer cel... DisGeNET Detail
Together, our data support the critical role of autophagy in pancreatic cancer and show that inhibit... DisGeNET Detail
Studies of the molecular pathology of pancreatic cancer have revealed that activation of KRAS, overe... DisGeNET Detail
pERK, pAKT and p53 as tissue biomarkers in erlotinib-treated patients with advanced pancreatic cance... DisGeNET Detail
We investigated the prevalence of germline mutations in APC, ATM, BRCA1, BRCA2, CDKN2A, MLH1, MSH2, ... DisGeNET Detail
Chromosomal rearrangements leading to gene disruption were prevalent, affecting genes known to be im... DisGeNET Detail
Therapeutic Targeting of the Warburg Effect in Pancreatic Cancer Relies on an Absence of p53 Functio... DisGeNET Detail
Here we report a systematic definition of how pancreatic cancer cells harboring mutant p53 respond t... DisGeNET Detail
Enhanced phosphorylation of p53 by microRNA-26a leading to growth inhibition of pancreatic cancer. DisGeNET Detail
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Conversely, DEK loss results in cell death in HPV-positive cervical cancer cells at least in part th... DisGeNET Detail
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Cantharidin inhibits cell proliferation and promotes apoptosis in tongue squamous cell carcinoma thr... DisGeNET Detail
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Somatic mutations contributing to the development of RS include TP53 disruption, c-myc activation, C... DisGeNET Detail
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Detection p53 gene deletion in hematological malignancies using fluorescence in situ hybridization: ... DisGeNET Detail
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We found that four of the variants (rs3829787, rs3841324, rs588765 and rs3743073) were associated wi... DisGeNET Detail
For children with TP53 mutant malignant gliomas, one year overall survival was 63 ± 12 and 23 ± 10 %... DisGeNET Detail
A greater number of copies of mutated TP53 were significantly associated to increased tumor aggressi... DisGeNET Detail
We show that (i) in the choroid plexus carcinoma, the germline mutation was detected in a homozygous... DisGeNET Detail
The TP53 mutation detection rate in children presenting with ACC or choroid plexus carcinomas, and i... DisGeNET Detail
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Patients with p53 mutations were older (p<.0001) and had higher numbers of liver metastases (p=.005)... DisGeNET Detail
Assessing the TP53 marker type in patients treated with or without neoadjuvant chemotherapy for rese... DisGeNET Detail
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We discuss the shared properties of cancer and neurodegenerative diseases and how the prion-like pro... DisGeNET Detail
The p53 mutation spectrum in hepatocellular carcinoma from Guangxi, China : role of chronic hepatiti... DisGeNET Detail
FBP1 is barely detectable in normal differentiated cells; its overexpression in HCC tumors with the ... DisGeNET Detail
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Normal and functional TP53 in genetically stable myxoid/round cell liposarcoma. DisGeNET Detail
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For instance, a greater absolute risk reduction of lung and upper aerodigestive cancers in smokers t... DisGeNET Detail
Genomic landscape of Ewing sarcoma defines an aggressive subtype with co-association of STAG2 and TP... DisGeNET Detail
A growing collection of retrospective studies have suggested that TP53 mutations and/or CDKN2A delet... DisGeNET Detail
CD99 triggering in Ewing sarcoma delivers a lethal signal through p53 pathway reactivation and coope... DisGeNET Detail
RETRA exerts anticancer activity in Ewing's sarcoma cells independent of their TP53 status. DisGeNET Detail
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For instance, a greater absolute risk reduction of lung and upper aerodigestive cancers in smokers t... DisGeNET Detail
To determine the presence of HPV in genital skin squamous cell carcinomas and to see the relationshi... DisGeNET Detail
However, the presence of p53 mutations in skin premalignant lesions suggests that these represent ea... DisGeNET Detail
Formation of γH2AX foci (a marker of DNA double-strand breaks), rates of foci clearance and apoptosi... DisGeNET Detail
For children with TP53 mutant malignant gliomas, one year overall survival was 63 ± 12 and 23 ± 10 %... DisGeNET Detail
TP53 Pro72 allele is enriched in oral tongue cancer and frequently mutated in esophageal cancer in I... DisGeNET Detail
The increased expression of pS(21)GSK3α and pS(9)GSK3β not only correlated positively with cyclin D1... DisGeNET Detail
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Overexpression of RASSF5 markedly suppressed cell proliferation and invasion, and induced cell apopt... DisGeNET Detail
Prognostic value of p53 alterations in human osteosarcoma: a meta analysis. DisGeNET Detail
p53-dependent activation of microRNA-34a in response to etoposide-induced DNA damage in osteosarcoma... DisGeNET Detail
Inactivation of p53 and/or Rb pathways restrains osteoblasts from cell-cycle exit and terminal diffe... DisGeNET Detail
Here, we established patient-derived iPSCs from a Li-Fraumeni syndrome (LFS) family and investigated... DisGeNET Detail
Germline TP53 variants and susceptibility to osteosarcoma. DisGeNET Detail
To identify the genes driving osteosarcoma development and metastasis, we performed a Sleeping Beaut... DisGeNET Detail
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In the printing company cases, immunohistochemical expression of p53 was observed in non-neoplastic ... DisGeNET Detail
The most common predisposition syndromes include germline TP53 mutations and constitutive alteration... DisGeNET Detail
Together, results suggested that miR-30b could modulate p53 pathway and enhance p53 gene therapy-ind... DisGeNET Detail
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Using an autochthonous model of pancreatic cancer driven by oncogenic Kras and the stochastic LOH of... DisGeNET Detail
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High-grade serous ovarian cancer (HG-SOC), a major histologic type of epithelial ovarian cancer (EOC... DisGeNET Detail
Selective tumor cell killing by triptolide in p53 wild-type and p53 mutant ovarian carcinomas. DisGeNET Detail
We demonstrated that in a unique population of HGSOC cancer cells with cancer stem cell properties, ... DisGeNET Detail
TP53 oncomorphic mutations predict resistance to platinum‑ and taxane‑based standard chemotherapy in... DisGeNET Detail
High-grade serous ovarian cancer (HGSOC) is the most aggressive histological type of epithelial ovar... DisGeNET Detail
Misregulation of polo-like protein kinase 1, P53 and P21WAF1 in epithelial ovarian cancer suggests p... DisGeNET Detail
To test if TP53 hot spot mutations (HSMs) confer differential chemotherapy resistance or survival ou... DisGeNET Detail
The study found a high expression of P53 (64%) and MIB1 (72%) and an expression of BCL2 (48%) in asc... DisGeNET Detail
Using an autochthonous model of pancreatic cancer driven by oncogenic Kras and the stochastic LOH of... DisGeNET Detail
Combined MYC family amplifications and P53 pathway defects commonly emerged at relapse, and all pati... DisGeNET Detail
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Ectopic expression of miR-506 inhibits NF-κB p65 expression, induces ROS accumulation and then activ... DisGeNET Detail
Nickel accumulation in lung tissues is associated with increased risk of p53 mutation in lung cancer... DisGeNET Detail
Rapamycin prevents strong phosphorylation of p53 on serine 46 and attenuates activation of the p53 p... DisGeNET Detail
TP53 mutations and lung cancer: not all mutations are created equal. DisGeNET Detail
Caveolin-1 regulates lung cancer stem-like cell induction and p53 inactivation in carbon nanotube-dr... DisGeNET Detail
AP-2α downregulation by cigarette smoke condensate is counteracted by p53 in human lung cancer cells... DisGeNET Detail
β-Elemene against human lung cancer via up-regulation of P53 protein expression to promote the relea... DisGeNET Detail
We evaluated 23 single nucleotide polymorphisms (SNPs) in the five nicotinic receptor related genes ... DisGeNET Detail
Evaluation of the mutagenicity of anti-B[a]P-diol epoxide with B[a]P-7,8-dione on p53 showed that th... DisGeNET Detail
Loss of p53 function may result in upregulation of 14-3-3γ in lung cancers. DisGeNET Detail
In addition, we used lung cancer cell lines with different p53 gene background (p53 null and p53 wil... DisGeNET Detail
Finally, we provide an analysis of discerning epidemiological data obtained from the IARC database a... DisGeNET Detail
SOX30, a novel epigenetic silenced tumor suppressor, promotes tumor cell apoptosis by transcriptiona... DisGeNET Detail
Moreover, co-treatment of MML and p53 inhibitor would be more effective in human lung cancer therapy... DisGeNET Detail
Thus, we conclude that p53 deficiency and KRAS mutation activate the NF-κB signaling to control chem... DisGeNET Detail
Our finding supports that mir-660 acts as a tumor suppressor miRNA and we suggest the replacement of... DisGeNET Detail
These results suggest that stroma-derived p53 plays a pivotal role in epithelial cancer progression ... DisGeNET Detail
Association of a p53 codon 72 gene polymorphism with environmental factors and risk of lung cancer: ... DisGeNET Detail
We identified mutations in both tumors, including KEAP1 (commonly mutated in lung cancers) in one, a... DisGeNET Detail
Treatment of cells with curcumin induced both p53 and the related protein p73 in head and neck and l... DisGeNET Detail
TP53 Codon 72 Polymorphisms and Lung Cancer Risk in the Bangladeshi Population. DisGeNET Detail
Furthermore, using data generated by The Cancer Genome Atlas consortium, we demonstrate that the eff... DisGeNET Detail
These results demonstrate that p53 is able to respond to exposure of arsenic or Cr(VI), suggesting t... DisGeNET Detail
However, p53-targeted therapies have limited application in lung cancer, since p53 is found to be mu... DisGeNET Detail
This RNA aptamer (p53R175H-APT) has a significantly stronger affinity to p53R175H than to the wild-t... DisGeNET Detail
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To conduct a phase I trial of a modified vaccinia Ankara (MVA) vaccine delivering wild-type human p5... DisGeNET Detail
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LINE-1 hypomethylation of ESCC was significantly associated with lymph node metastasis, lymphovascul... DisGeNET Detail
Increased p53 expression significantly correlated with high pathological grade and lymph node metast... DisGeNET Detail
Our findings underscore the importance of measuring the HPV16 RNA (E6*I) and TP53-mutation status fo... DisGeNET Detail
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Combined CDKN1A/TP53 mutation in bladder cancer is a therapeutic target. DisGeNET Detail
Overall results suggest that phosphorylated HER3, ERK1/2 and p53 may be used as biomarkers to determ... DisGeNET Detail
Our findings confirm the alternative role of FGFR3 and TP53 mutations in the development of bladder ... DisGeNET Detail
Recent developments in the field of molecular mutational pathway analyses based on next generation s... DisGeNET Detail
Association of TP53 gene polymorphisms with susceptibility of bladder cancer in Bangladeshi populati... DisGeNET Detail
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CFM-1, -4, and -5 inhibited NB cell growth, in vitro, independent of their p53 and MYCN status. DisGeNET Detail
Simultaneous Adrenocortical Carcinoma and Neuroblastoma in an Infant With a Novel Germline p53 Mutat... DisGeNET Detail
Of note, less than 2% of neuroblastoma tumors have a TP53 mutation at diagnosis. DisGeNET Detail
Treatment of wild-type TP53 neuroblastoma cell lines with both GSK2830371 and either doxorubicin or ... DisGeNET Detail
Genome wide expression profiling of p53 regulated miRNAs in neuroblastoma. DisGeNET Detail
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L-Leucine improves the anaemia in models of Diamond Blackfan anaemia and the 5q- syndrome in a TP53-... DisGeNET Detail
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Alternative lengthening of telomeres is enriched in, and impacts survival of TP53 mutant pediatric m... DisGeNET Detail
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Those tumors that lacked LOH 1p19q showed a high frequency of IDH1 mutations and loss of alpha thala... DisGeNET Detail
The mean of Olig2 LI of gliomas with 1p/19q loss ± IDH1/2 mutation, the majority of them being oligo... DisGeNET Detail
We found that oligoastrocytomas harbored mutations in TP53 (80%, 12/15) and ATRX (60%, 9/15) at freq... DisGeNET Detail
The TP53 and HIST1H3A genes were the hub nodes in the PPI network of DEGs from GBM, while CNTN2 was ... DisGeNET Detail
Thus, we analyzed the expression of p-CREB in a series of astrocytomas and oligodendrogliomas of dif... DisGeNET Detail
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Human gene copy number alteration data, microarray expression data, and TMA analysis indicate that T... DisGeNET Detail
The pathological diagnosis of malignant schwannoma indicated that the p53 expression was strongly po... DisGeNET Detail
We show that loss of laforin or malin results in the increased level and activity of p53, both in ce... DisGeNET Detail
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In this study we identified a previously unreported mechanism, involving disruption of p53 and NADPH... DisGeNET Detail
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There was no deletion 1p19q in 118 cases, codeletion 1p19q (57 cases), single deletion 1p (4 cases) ... DisGeNET Detail
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MDM2 is an important prognostic and predictive factor for platin-pemetrexed therapy in malignant ple... DisGeNET Detail
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Polysomy 7, polysomy 18, p16 deletion, and p53 deletion were significantly more frequent in invasive... DisGeNET Detail
More than 50% of human cancers contain a mutation or deletion of the p53 gene, and p53R175 is one of... DisGeNET Detail
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Using an autochthonous model of pancreatic cancer driven by oncogenic Kras and the stochastic LOH of... DisGeNET Detail
However, the presence of p53 mutations in skin premalignant lesions suggests that these represent ea... DisGeNET Detail
Helicobacter pylori infection and a P53 codon 72 single nucleotide polymorphism: a reason for an une... DisGeNET Detail
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Previous genetic studies on colorectal carcinomas (CRC) have identified multiple somatic mutations i... DisGeNET Detail
Taken together, our results provide evidence for RTK/RAS pathway activation and p53 deficiency as a ... DisGeNET Detail
Mutations in genes relating to genome integrity (TP53, BRCA2), chromatin remodeling (ARID1A), cell a... DisGeNET Detail
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The tumor suppressor TP53 is mutated in approximately 30% of breast adenocarcinomas, with varying fr... DisGeNET Detail
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Tumoral TP53 and/or CDKN2A alterations are not reliable prognostic biomarkers in patients with local... DisGeNET Detail
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Characteristics and survival of patients with advanced cancer and p53 mutations. DisGeNET Detail
Cancer genome studies document recurrent genetic inactivation of RB1 and TP53, and the inactivation ... DisGeNET Detail
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In this study, we compared the immunoreactivities of Bcl-2, Bax and p53 proteins in ovarian tumors a... DisGeNET Detail
Since mutations in TP53 occur in nearly all ovarian tumors, the objective of this study was to deter... DisGeNET Detail
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In sporadic intestinal adenocarcinomas with strong p53 immunostaining (mutated TP53), ACSL5-related ... DisGeNET Detail
Strong immunoreactivity of Bcl-2 and mild immunoreactivities of Bax and p53 were detected in ovarian... DisGeNET Detail
Comparison of neuroendocrine differentiation and KRAS/NRAS/BRAF/PIK3CA/TP53 mutation status in prima... DisGeNET Detail
Prognostic value of microsatellite instability and p53 expression in metastatic colorectal cancer tr... DisGeNET Detail
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Somatic mutations or deletions of TP53 and PTEN in ductal carcinoma in situ lesions have been implic... DisGeNET Detail
Assessment of changes in the BRCA2 and P53 genes in breast invasive ductal carcinoma in northeast Br... DisGeNET Detail
Mitochondrial DNA alterations correlate with the pathological status and the immunological ER, PR, H... DisGeNET Detail
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Mutation or loss of p53 differentially modifies TGFβ action in ovarian cancer. DisGeNET Detail
In this study, the nuclear expression levels of γ-H2AX and p53 using immunohistochemical (IHC) study... DisGeNET Detail
This study shows that triptolide selectively kills ovarian cancer cells with different p53 status pr... DisGeNET Detail
Association between a single nucleotide polymorphism in the TP53 region and risk of ovarian cancer. DisGeNET Detail
The observed upregulation of pro-apoptotic genes and apoptosis in cancer cells without p53 in respon... DisGeNET Detail
Genomic classification of serous ovarian cancer with adjacent borderline differentiates RAS pathway ... DisGeNET Detail
Furthermore, tumors containing oncomorphic TP53 mutations displayed unique protein expression profil... DisGeNET Detail
TP53 remains as the most frequently altered gene in high grade serous ovarian cancer and Ion Torrent... DisGeNET Detail
Detection of somatic TP53 mutations in tampons of patients with high-grade serous ovarian cancer. DisGeNET Detail
Molecular characterization of an intact p53 pathway subtype in high-grade serous ovarian cancer. DisGeNET Detail
Although the effect of new drugs such as poly(ADP-ribose) polymerase inhibitors are being investigat... DisGeNET Detail
Co-immunoprecipitation and western blotting showed significantly lower levels of p53 and p53 Ser15-p... DisGeNET Detail
The present study aimed to clarify the role of PLK1, P53 and P21WAF1 in the prognosis of ovarian can... DisGeNET Detail
CR389, a benzoimidazolyl pyridinone analog, induces cell cycle arrest and apoptosis via p53 activati... DisGeNET Detail
Overall, FBN1, acts at the downstream of Aur A and BRCA2, promotes ovarian cancer metastasis through... DisGeNET Detail
First, we observed the upregulation protein level of p53 target genes in cisplatin-resistant or cisp... DisGeNET Detail
There is a link between miR-7 expression and TP53 status and tumour grade in serous OC. DisGeNET Detail
TP53 hot spot mutations in ovarian cancer: selective resistance to microtubule stabilizers in vitro ... DisGeNET Detail
We propose that this unique ability of APR-246/MQ to bind to cysteines in both mutant p53 and glutat... DisGeNET Detail
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Mechanistic studies reveal that attenuated HNSCC cell growth in response to DEK loss was associated ... DisGeNET Detail
Increased growth-inhibitory and cytotoxic activity of arsenic trioxide in head and neck carcinoma ce... DisGeNET Detail
Predicting survival in head and neck squamous cell carcinoma from TP53 mutation. DisGeNET Detail
We previously showed that CK2 is often aberrantly expressed and activated in head and neck squamous ... DisGeNET Detail
Emphasis is placed on the therapeutic implications of genes frequently altered in HNSCCs (i.e., TP53... DisGeNET Detail
These results indicate that HNSCC cells expressing high-risk p53 mutations are significantly sensiti... DisGeNET Detail
TP53 is the most frequently altered gene in head and neck squamous cell carcinoma, with mutations oc... DisGeNET Detail
The EAp53 approach clearly identifies a subset of high-risk TP53 mutations associated with decreased... DisGeNET Detail
Combined TP53 mutation/3p loss correlates with decreased radiosensitivity and increased matrix-metal... DisGeNET Detail
Human papillomavirus (HPV), p16 expression, and TP53 mutations are known prognostic factors in head ... DisGeNET Detail
Homozygous deletions of UGT2B17 modifies effects of smoking on TP53-mutations and relapse of head an... DisGeNET Detail
Our findings underscore the importance of measuring the HPV16 RNA (E6*I) and TP53-mutation status fo... DisGeNET Detail
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Haploinsufficiency of ribosomal proteins (RPs) and upregulation of the tumour suppressor TP53 have b... DisGeNET Detail
In this study, we establish the DBA model in zebrafish using an RPS24 morpholino and found that RPS2... DisGeNET Detail
Genetic depletion of Snail1 in MSCs that are deficient in p53 tumor suppressor downregulates MSC mar... DisGeNET Detail
Most childhood sarcomas are TP53 wild type at diagnosis, although approximately 5-10% have MDM2 ampl... DisGeNET Detail
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TP53 was the most frequently mutated gene in TETs (n = 13; 17%), especially in TCs (26%), and was as... DisGeNET Detail
Two dedifferentiated SFT cases harbored both TP53 and TERT promoter mutations. DisGeNET Detail
Exome sequencing of pleuropulmonary blastoma reveals frequent biallelic loss of TP53 and two hits in... DisGeNET Detail
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These accumulations were associated with decreased levels of Cyclin A1, B1, and E1, and increased ex... DisGeNET Detail
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We identified a unique case of adult B-ALL with masked low hypodiploidy (mLH) by genomic duplication... DisGeNET Detail
Our findings support the recent notion that heterozygous TP53 mutation may be a function of normal a... DisGeNET Detail
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We performed genomic profiling of post-MPN AML samples; these studies demonstrate somatic tumor prot... DisGeNET Detail
L-Leucine improves the anaemia in models of Diamond Blackfan anaemia and the 5q- syndrome in a TP53-... DisGeNET Detail
The early acquisition of TP53 mutations in the founding HSPC clone probably contributes to the frequ... DisGeNET Detail
TP53 mutations are highly and similarly prevalent in t-MDS and t-AML but mutations in genes other th... DisGeNET Detail
TP53 mutation characteristics in therapy-related myelodysplastic syndromes and acute myeloid leukemi... DisGeNET Detail
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Coexistent TP53 mutations were identified in 63% of the TSC2-mutated PEComas. DisGeNET Detail
We explored lncRNAs profilings in PanIN cell line (SH-PAN) isolated from Pdx-1-Cre; LSL-Kras (G12D/+... DisGeNET Detail
The authors show that combined loss of autophagy and p53 dramatically promotes progression from earl... DisGeNET Detail
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This is the first case of ameloblastic carcinoma with a mutation of the p53 gene that has been assoc... DisGeNET Detail
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TP53 status regulates ACSL5-induced expression of mitochondrial mortalin in enterocytes and colorect... DisGeNET Detail
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Massively parallel sequencing identifies recurrent mutations in TP53 in thymic carcinoma associated ... DisGeNET Detail
TP53 was the most frequently mutated gene in TETs (n = 13; 17%), especially in TCs (26%), and was as... DisGeNET Detail
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Chromosome instability induced by Mps1 and p53 mutation generates aggressive lymphomas exhibiting an... DisGeNET Detail
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Five new TP53 mutations were identified in six pedigrees from hereditary cancer clinics. DisGeNET Detail
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Genetic inactivation of the TP53 gene in ccRCC is rare, suggesting that an alternate mechanism allev... DisGeNET Detail
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Mutations in TP53 (20/28, 71%) and ATRX (15/28, 54%) were enriched in astrocytic tumors compared to ... DisGeNET Detail
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On the other hand, in well-differentiated PDACs measuring ≤ 1 cm, the incidence of abnormal immunola... DisGeNET Detail
We explored lncRNAs profilings in PanIN cell line (SH-PAN) isolated from Pdx-1-Cre; LSL-Kras (G12D/+... DisGeNET Detail
Mutations in p53 and RAS potently cooperate in oncogenic transformation, and correspondingly, these ... DisGeNET Detail
Based on these findings, we propose the existence of a hierarchical signaling network regulating PDA... DisGeNET Detail
Impact of TP53 codon 72 and MDM2 SNP 309 polymorphisms in pancreatic ductal adenocarcinoma. DisGeNET Detail
Using genetically engineered mouse models, we show that heterozygous mutation of Dpc4/Smad4 attenuat... DisGeNET Detail
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A miR-199a/miR-214 self-regulatory network via PSMD10, TP53 and DNMT1 in testicular germ cell tumor. DisGeNET Detail
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However, this interpretation has been challenged by a number of recent in vivo studies, demonstratin... DisGeNET Detail
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We detected a total of 1,764 nonsynonymous single nucleotide variants at a rate of 8 per Mb in BP-NE... DisGeNET Detail
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Genetic deletion of the telomerase subunit Terc in a retroviral mouse AML model induces cell-cycle a... DisGeNET Detail
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We have predicted three deleterious coding non-synonymous single nucleotide polymorphisms rs11540654... DisGeNET Detail
Here, we investigated the role of p53 in breast tumor cell invasion, migration, and EMT and examined... DisGeNET Detail
Lymphocyte Invasion in IC10/Basal-Like Breast Tumors Is Associated with Wild-Type TP53. DisGeNET Detail
A positive correlation was found between expression of mutant gene p53 protein and the degree of mal... DisGeNET Detail
Through the described mechanism, elevated CXCR5 expression may contribute to abnormal cell survival ... DisGeNET Detail
These results have translational relevance, demonstrating that TP53 mutant breast tumor growth can b... DisGeNET Detail
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Molecular genetic analysis revealed an uncommon mutation; 249: AGG →ATG in the TP53 gene, which has ... DisGeNET Detail
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The aims of present study are to investigate the p53 mutation spectrum in HBV- and AFB1-related hepa... DisGeNET Detail
It is concluded that both of the non-structural genes, NS3 and NS5A, of HCV play important roles in ... DisGeNET Detail
Hepatitis B Virus Core Promoter A1762T/G1764A (TA)/T1753A/T1768A Mutations Contribute to Hepatocarci... DisGeNET Detail
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Mutant p53 Amplifies Epidermal Growth Factor Receptor Family Signaling to Promote Mammary Tumorigene... DisGeNET Detail
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A cell-permeable TAT-p53LZ2 effectively inhibits the cancer cell growth in wild-type but not mutant ... DisGeNET Detail
However, whether INZ could suppress cancer cell growth independently of p53 activity is still elusiv... DisGeNET Detail
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These results indicate that absence of CDH1 and TP53 in endometrial cells initiates chronic inflamma... DisGeNET Detail
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Our results support the idea that mutations of the FGFR3 and TP53 genes are rare or absent in urothe... DisGeNET Detail
In the Balkan and Taiwan, the relationship between exposure to aristolochic acid and risk of urothel... DisGeNET Detail
Re-engineered p53 activates apoptosis in vivo and causes primary tumor regression in a dominant nega... DisGeNET Detail
In this study, Hep3B cells which are p53 null were used to investigate the anti-tumor effect of PBLs... DisGeNET Detail
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Elevated p57Kip2 induces G1/S phase cell cycle arrest but inhibits cell death in response to DNA dam... DisGeNET Detail
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Cytoplasmic/nuclear beta-catenin and P53 accumulation was observed in the majority of paediatric and... DisGeNET Detail
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ECCCs had SCA-like features with rare expression of estrogen receptor/progesterone receptor (18.8%/6... DisGeNET Detail
However, p53 therapy for GBM is limited by lack of efficient delivery across the blood brain barrier... DisGeNET Detail
A tumor-targeting p53 nanodelivery system limits chemoresistance to temozolomide prolonging survival... DisGeNET Detail
Detection of p53 mutations in proliferating vascular cells in glioblastoma multiforme. DisGeNET Detail
It has been found that the reintroduction of WWOX induced p53-mutant GBM cells to undergo apoptosis,... DisGeNET Detail
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The C/C genotype of P53 gene codon 72 increases the risk of developing sporadic KCOT and may be a us... DisGeNET Detail
Nuclear positive reaction of TP53 was lower in LAMN compared with those of other tumors. DisGeNET Detail
In the printing company cases, immunohistochemical expression of p53 was observed in non-neoplastic ... DisGeNET Detail
Non-neoplastic (n=28), noninvasive (n=28), and invasive (n=11) spots were then analyzed for aneuploi... DisGeNET Detail
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L-Leucine improves the anaemia in models of Diamond Blackfan anaemia and the 5q- syndrome in a TP53-... DisGeNET Detail
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Prevalence and functional consequence of TP53 mutations in pediatric adrenocortical carcinoma: a chi... DisGeNET Detail
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Mutational profiling of familial male breast cancers reveals similarities with luminal A female brea... DisGeNET Detail
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No variation of p16, p21, PLUNC (palate, lung, and nasal epithelium clone protein) and p53 expressio... DisGeNET Detail
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Nucleostemin knocking-down causes cell cycle arrest and apoptosis in human T-cell acute lymphoblasti... DisGeNET Detail
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Mapping p53 mutations in low-grade glioma: a voxel-based neuroimaging analysis. DisGeNET Detail
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We also found significant inverse correlation between FGFR3 mutations and TP53 alterations in urothe... DisGeNET Detail
Taken together, our results provide evidence for RTK/RAS pathway activation and p53 deficiency as a ... DisGeNET Detail
UV-independent p53 mutations in sebaceous carcinoma of the eyelid. DisGeNET Detail
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Among these biomarkers, p53 is the strongest prognostic marker in OPC and p53 in addition to p16 sup... DisGeNET Detail
The biology of HPV-positive oropharyngeal cancer is distinct; it includes p53 degradation, retinobla... DisGeNET Detail
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Targeted, massively parallel DNA sequencing and molecular inversion probe microarray analysis reveal... DisGeNET Detail
She presented with a clinical diagnosis of Li-Fraumeni-like syndrome (LFL), showing papillary thyroi... DisGeNET Detail
A significant percentage (5-10%) of pediatric cancers are associated with hereditary cancer syndrome... DisGeNET Detail
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In addition, it stimulated p53 promoter activity and downregulated the protein expression of c-Myc i... DisGeNET Detail
Collectively, these results suggest that LOC401317 is directly regulated by p53 and exerts antitumor... DisGeNET Detail
The results suggested that the Arg399Gln polymorphism of XRCC1 gene, the 1G/2G polymorphism of MMP-1... DisGeNET Detail
Association between p53 codon 72 polymorphisms and clinical outcome of nasopharyngeal carcinoma. DisGeNET Detail
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Persistent STAT5 activation in myeloid neoplasms recruits p53 into gene regulation. DisGeNET Detail
Malignant melanoma is a highly aggressive cancer that retains functional p53 and p73, and drug unres... DisGeNET Detail
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Diffuse p16 expression was associated with younger age at presentation (P<0.0001), basaloid and wart... DisGeNET Detail
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Forty-two deleterious germline mutations were identified in 21 genes of 34 patients, including 18 (1... DisGeNET Detail
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Combined MYC family amplifications and P53 pathway defects commonly emerged at relapse, and all pati... DisGeNET Detail
The N+&C+ group was associated with larger tumor size, higher grade, negativity for estrogen and pro... DisGeNET Detail
SOCS3-mediated regulation of inflammatory cytokines in PTEN and p53 inactivated triple negative brea... DisGeNET Detail
Thymoquinone, a bioactive component of black caraway seeds, causes G1 phase cell cycle arrest and ap... DisGeNET Detail
Only lymph node status was marginally significantly associated with poor prognosis of TNBC (P = 0.05... DisGeNET Detail
Here, we used the high prevalence of TP53 mutations in triple negative breast cancer (TNBC) to compa... DisGeNET Detail
Combined deletion of Pten and p53 in mammary epithelium accelerates triple-negative breast cancer wi... DisGeNET Detail
In the present study, we used recombinant human p53 adenovirus (Ad-p53) and EGFR inhibitor gefitinib... DisGeNET Detail
Primary mouse mammary epithelial cells (mMEC) with defined genetic features were used to delineate t... DisGeNET Detail
Results indicated that TNBC patients with a p53-positive tumor had a shorter relapse-free and overal... DisGeNET Detail
Gain-of-function mutations in TP53 are a frequent occurrence in TNBC and have been demonstrated to r... DisGeNET Detail
Another highly important mutation can occur in TP53 resulting in a triple negative breast cancer. DisGeNET Detail
Further, our data suggest that loss of the p53 tumor suppressor cooperates with Mychigh/TXNIPlow-dri... DisGeNET Detail
The expression of p53 was higher in luminal B, HER2-enriched, and triple-negative breast cancers, an... DisGeNET Detail
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Frequency and features of TP53 mutation in 30 Chinese patients with sporadic basal cell carcinoma. DisGeNET Detail
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Immunohistochemistry for IMP3 and p53 was performed and evaluated in 48 HGSCs with STIC, 62 HGSCs wi... DisGeNET Detail
High-grade serous carcinomas (HGSC) are TP53-mutated and are thought to be rarely associated with bo... DisGeNET Detail
TP53 mutations are the single most commonly identified mutations in aggressive sporadic high-grade s... DisGeNET Detail
Knockdown of p53 in immortalized FTE cells and in four HGSC-derived cell lines expressing different ... DisGeNET Detail
Ovulation is the strongest risk factor for ovarian high-grade serous carcinoma (HGSC) that largely o... DisGeNET Detail
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Moreover, the p53 protein is able to interact with both wild type Nkx2.5 and its mutant ΔNkx2.5 (aa ... DisGeNET Detail
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An analysis of granulation patterns, MIB-1 proliferation indices and p53 expression in 101 patients ... DisGeNET Detail
Overexpression of p53 was detected only in high-grade dysplasia and invasive adenocarcinoma. DisGeNET Detail
The authors show that combined loss of autophagy and p53 dramatically promotes progression from earl... DisGeNET Detail
False-negative controls consisted in microdissecting fresh-frozen tumor tissues both from a patient ... DisGeNET Detail
Formalin Fixed Paraffin Embedded tissue were studied for miRNA expression, KRAS, BRAF, PIK3CA mutati... DisGeNET Detail
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These methylation epigenotypes, with specific genomic aberrations, are mostly completed by the adeno... DisGeNET Detail
Chk2, phosphorylated Chk2 (pChk2), and TP53 were immunostained in 4 cases of adenoma (AD), 5 non-muc... DisGeNET Detail
Formalin Fixed Paraffin Embedded tissue were studied for miRNA expression, KRAS, BRAF, PIK3CA mutati... DisGeNET Detail
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Ameloblastic carcinoma developing in preexisting ameloblastoma with a mutation of the p53 gene: a ca... DisGeNET Detail
We found that hTERT expression level was significantly lower in ALS patients and was correlated eith... DisGeNET Detail
TP53 mutational status is a potential marker for risk stratification in Wilms tumour with diffuse an... DisGeNET Detail
TP53 mutations, which result in its overexpression, in combination with TERT promoter mutations seem... DisGeNET Detail
Mechanistically, active mTORC1 is required to prevent a likely upregulation of the cell-cycle inhibi... DisGeNET Detail
Haploinsufficiency of ribosomal proteins (RPs) and upregulation of the tumour suppressor TP53 have b... DisGeNET Detail
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The majority of astrocytomas harbor concurrent TP53 and ATRX mutations, while most oligodendroglioma... DisGeNET Detail
We found that oligoastrocytomas harbored mutations in TP53 (80%, 12/15) and ATRX (60%, 9/15) at freq... DisGeNET Detail
In addition, p-CREB expression correlated with higher Ki-67 labeling index (P = .049) and p53 overex... DisGeNET Detail
These findings suggest that CDKN2A testing may provide further clinical aid in lower-grade glioma su... DisGeNET Detail
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Role of p53 in systemic autoimmune diseases. DisGeNET Detail
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Immunostaining for p53 is the only candidate biomarker deemed ready for prime time. This has been re... DisGeNET Detail
Aberrant TP53 detected by combining immunohistochemistry and DNA-FISH improves Barrett's esophagus p... DisGeNET Detail
Our analysis showed that oncogene amplification typically occurred as a late event and that TP53 mut... DisGeNET Detail
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Combined CDKN1A/TP53 mutation in bladder cancer is a therapeutic target. DisGeNET Detail
Overall results suggest that phosphorylated HER3, ERK1/2 and p53 may be used as biomarkers to determ... DisGeNET Detail
Our findings confirm the alternative role of FGFR3 and TP53 mutations in the development of bladder ... DisGeNET Detail
Recent developments in the field of molecular mutational pathway analyses based on next generation s... DisGeNET Detail
Association of TP53 gene polymorphisms with susceptibility of bladder cancer in Bangladeshi populati... DisGeNET Detail
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We identified TP53 mutations in MYC+/BCL2+ lymphomas at a frequency intermediate between diffuse lar... DisGeNET Detail
Reversion of apoptotic resistance of TP53-mutated Burkitt lymphoma B-cells to spindle poisons by exo... DisGeNET Detail
INZ(c) treatment decreased c-Myc expression at both mRNA and protein level, and suppressed c-Myc tra... DisGeNET Detail
Although the status of RB1 and P53 between carcinoids and HGNETs were apparently different, the DNTF... DisGeNET Detail
Mutational profiling of familial male breast cancers reveals similarities with luminal A female brea... DisGeNET Detail
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We propose that the mutation of a single p53 allele provides a pro-oncogenic function early in skin ... DisGeNET Detail
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Somatic mutations or deletions of TP53 and PTEN in ductal carcinoma in situ lesions have been implic... DisGeNET Detail
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Chk2, phosphorylated Chk2 (pChk2), and TP53 were immunostained in 4 cases of adenoma (AD), 5 non-muc... DisGeNET Detail
TP53 mutation occurred more frequently in carcinomas than borderline tumors (56.8 % and 11.5 %, resp... DisGeNET Detail
These results suggest that intratumor genetic heterogeneity may be an important factor in determinin... DisGeNET Detail
Our study indicates that the detection of the KRAS and p53 mutations in BAL fluids could be a helpfu... DisGeNET Detail
Nondisruptive p53 mutations are associated with shorter survival in patients with advanced non-small... DisGeNET Detail
Mutations in TP53 are common in non-small cell lung cancer. DisGeNET Detail
This is a revised case report of a 52 year old Caucasian female with Li-Fraumeni syndrome with a rar... DisGeNET Detail
Promotion of p53 expression and reactive oxidative stress production is involved in zerumbone-induce... DisGeNET Detail
SETDB1 positively stimulated activity of the WNT-β-catenin pathway and diminished P53 expression, re... DisGeNET Detail
Polymorphisms of p53 and MDM2 genes are associated with severe toxicities in patients with non-small... DisGeNET Detail
Genetic mutation of p53 and suppression of the miR-17∼92 cluster are synthetic lethal in non-small c... DisGeNET Detail
In non-small cell lung cancer (NSCLC), both USP7 expression and p53 gene status were reported to be ... DisGeNET Detail
USP22 promotes NSCLC tumorigenesis via MDMX up-regulation and subsequent p53 inhibition. DisGeNET Detail
Association of p53 and mdm2 in the development and progression of non-small cell lung cancer. DisGeNET Detail
VEGF-A Expression Correlates with TP53 Mutations in Non-Small Cell Lung Cancer: Implications for Ant... DisGeNET Detail
Further experiments demonstrated that PANDAR expression was induced by p53, and chromatin immunoprec... DisGeNET Detail
We analyzed human non-small cell lung cancer (NSCLC) cell lines either wild type (wt) or mutated in ... DisGeNET Detail
Tumor-suppressive p53 Signaling Empowers Metastatic Inhibitor KLF17-dependent Transcription to Overc... DisGeNET Detail
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We observed a good overall stability between primary RCC and corresponding xenografted RCC at P1 and... DisGeNET Detail
Here, we show that apoptosis-resistant RCC cells have a disconnect between activation of p53 and upr... DisGeNET Detail

Overlapped Transcript Coordinates

Gene Transcript ID Exon Number Chromosome Start Stop Type Amino Mutation Transcript Position Links

Overlapped Transcript

Gene Transcript ID Chromosome Start Stop Links
Gene
-
dbSNP
rs28934271 dbSNP
Genome
hg19
Position
chr17:7,565,097-7,590,864
Variant Type
snv
Genome browser