motor neuron disease
Information
- Disease name
- motor neuron disease
- Disease ID
- DOID:231
- Description
- "A neurodegenerative disease that is located_in the motor neurons." [url:http\://en.wikipedia.org/wiki/Motor_neuron_disease]
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
| Genes | Mutation | Description | Source | Links |
|---|
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT04997954 | Active, not recruiting | Phase 4 | EMERALD TRIAL Open Label Extension Study | May 17, 2021 | January 2024 |
| NCT03811301 | Active, not recruiting | N/A | [BrainConnexion] - Neurodevice Phase I Trial | November 21, 2017 | August 27, 2023 |
| NCT03690791 | Active, not recruiting | Phase 3 | Efficacy of Cannabinoids in Amyotrophic Lateral Sclerosis or Motor Neurone Disease | January 9, 2019 | January 30, 2024 |
| NCT00071435 | Completed | Brain Function in Primary Lateral Sclerosis | October 2003 | February 2006 | |
| NCT00076687 | Completed | Phase 2 | Safety Study of Botulinum Toxin Type A in Post-Upper Limb Stroke Patients With Reduced Lung Function | October 2003 | August 2009 |
| NCT00324454 | Completed | Phase 2 | Levetiracetam for Cramps, Spasticity and Neuroprotection in Motor Neuron Disease | May 2006 | June 2008 |
| NCT05314348 | Completed | N/A | Surface EMG and Ultrasound in MND | June 11, 2019 | December 1, 2019 |
| NCT00537641 | Completed | Efficacy of Noninvasive Ventilation in Amyotrophic Lateral Sclerosis (ALS) | May 2007 | June 2011 | |
| NCT00714636 | Completed | Cerebrospinal Fluid Repository | October 2006 | October 2008 | |
| NCT00716131 | Completed | Amyotrophic Lateral Sclerosis (ALS) Tissue Donation Program | April 2007 | November 2016 | |
| NCT04939818 | Completed | Clinical Feasibility of Speech Phenotyping for Remote Assessment of Neurodegenerative and Psychiatric Disorders | June 14, 2021 | September 15, 2022 | |
| NCT04894240 | Completed | Phase 1 | A Study of Monepantel in Individuals With Motor Neurone Disease | June 28, 2022 | November 29, 2023 |
| NCT00718393 | Completed | Compassionate Use of Ceftriaxone in Patients With Amyotrophic Lateral Sclerosis (ALS) | June 2007 | October 2015 | |
| NCT04788745 | Completed | Phase 2 | Targeting Metabolic Flexibility in Amyotrophic Lateral Sclerosis (ALS) | June 29, 2021 | May 24, 2023 |
| NCT00718458 | Completed | EEG-Based Brain-Computer Interface Project for Individuals With Amyotrophic Lateral Sclerosis (ALS) | August 2007 | December 2016 | |
| NCT00718497 | Completed | Comparing The Cyberlink Control System to the Manual Letter Board for Communication Purposes in the ALS Patient Population | August 2007 | May 2012 | |
| NCT00956488 | Completed | Phase 1/Phase 2 | Supported Treadmill Ambulation Training (STAT) for Patients Diagnosed With Amyotrophic Lateral Aclerosis | September 2008 | September 2010 |
| NCT01143428 | Completed | Oxidative Stress in Motor Neuron Disease: COSMOS Add-On Study | May 13, 2010 | August 3, 2015 | |
| NCT01369901 | Completed | Phase 1/Phase 2 | Effect of Functional Exercise in Patients With Spinal Bulbar Muscular Atrophy | June 8, 2011 | February 28, 2018 |
| NCT00001220 | Completed | Ultrasound and Videofluoroscopy for Diagnosing Swallowing Disorders | October 1987 | November 2005 | |
| NCT01495390 | Completed | A Longitudinal Study of Amyotrophic Lateral Sclerosis (ALS) Biomarkers | November 2011 | December 31, 2016 | |
| NCT01758510 | Completed | Phase 1 | Safety Study of HLA-haplo Matched Allogenic Bone Marrow Derived Stem Cell Treatment in Amyotrophic Lateral Sclerosis | December 2012 | April 10, 2017 |
| NCT01776970 | Completed | Phase 2/Phase 3 | Safety and Efficacy on Spasticity Symptoms of a Cannabis Sativa Extract in Motor Neuron Disease | January 2013 | December 2015 |
| NCT04430686 | Completed | Respiratory Complications in ALS | June 1, 2020 | September 1, 2021 | |
| NCT01951924 | Completed | Phase 3 | LIME Study (LFB IVIg MMN Efficacy Study) | December 2013 | July 2016 |
| NCT02011204 | Completed | Study of Electrical Impedance Myography (EIM) in ALS | November 2013 | March 2016 | |
| NCT02124057 | Completed | Study of Hepatic Function in Patients With Spinal and Bulbar Muscular Atrophy | August 4, 2014 | November 19, 2020 | |
| NCT03929068 | Completed | Phase 1 | Sinemet for Spasticity and Function in Amyotrophic Lateral Sclerosis and Primary Lateral Sclerosis | May 13, 2019 | July 8, 2022 |
| NCT02464748 | Completed | N/A | Telehealth in Motor Neurone Disease | September 2014 | April 2016 |
| NCT02469896 | Completed | Phase 2 | A Trial of Tocilizumab in ALS Subjects | November 2015 | July 11, 2018 |
| NCT02574390 | Completed | Answer ALS: Individualized Initiative for ALS Discovery | December 2015 | January 1, 2020 | |
| NCT02819765 | Completed | Deep Phenotyping in Patients With ALS | February 7, 2017 | November 9, 2021 | |
| NCT03809845 | Completed | N/A | Serial Fasciculation Measurements in Motor Neurone Disease | July 6, 2017 | March 1, 2019 |
| NCT02870634 | Completed | Phase 1 | Phase 1 Dose Escalation and PK Study of Cu(II)ATSM in ALS/MND | November 16, 2016 | January 30, 2020 |
| NCT02987413 | Completed | Phase 1 | Escalated Application of Mesenchymal Stem Cells in Amyotrophic Lateral Sclerosis Patients | April 28, 2015 | April 5, 2017 |
| NCT03797677 | Completed | N/A | MN4000 for Treatment of CF and MND Patients in the Home Setting | March 9, 2017 | November 30, 2017 |
| NCT03114215 | Completed | Phase 2 | Effect of MD1003 in Amyotrophic Lateral Sclerosis | June 29, 2016 | December 2017 |
| NCT03127514 | Completed | Phase 2 | AMX0035 in Patients With Amyotrophic Lateral Sclerosis (ALS) | June 22, 2017 | November 24, 2019 |
| NCT03154450 | Completed | N/A | EncoreAnywhere Use in Motor Neurone Disease | January 21, 2016 | April 1, 2017 |
| NCT03706391 | Completed | Study of ALS Reversals 4: LifeTime Exposures | September 26, 2018 | June 1, 2020 | |
| NCT03356288 | Completed | The General Breathing Record Study | August 9, 2017 | July 4, 2018 | |
| NCT03705390 | Completed | Phase 2 | A Safety and Tolerability Study of ILB in Patients With Amyothrophic Lateral Sclerosis (ALS) | March 29, 2019 | July 28, 2021 |
| NCT03487263 | Completed | Phase 1 | Dose-Escalation, Safety and Pharmacokinetic Study of IC14 in Motor Neurone Disease | October 1, 2017 | December 30, 2018 |
| NCT00001780 | Completed | Magnetic Stimulation of the Human Nervous System | February 1998 | November 2005 | |
| NCT06256107 | Completed | N/A | Virtual Reality in Motor Neurone Disease | January 13, 2021 | October 31, 2023 |
| NCT01459302 | Enrolling by invitation | Genetic Study of Familial and Sporadic ALS/Motor Neuron Disease, Miyoshi Myopathy and Other Neuromuscular Disorders | January 2009 | October 2024 | |
| NCT04961450 | Enrolling by invitation | Explore Biomarkers of Motor Neuron Disease/Frontal Dementia Spectrum Disease in China | June 24, 2021 | December 31, 2030 | |
| NCT05725759 | Enrolling by invitation | Rehabilitation in SOD1 ALS Treated With Tofersen | November 8, 2022 | December 2024 | |
| NCT06376279 | Enrolling by invitation | Genetic Diagnosis in Inborn Errors of Metabolism | April 29, 2008 | December 31, 2030 | |
| NCT05784727 | Not yet recruiting | N/A | Technical Evaluation of Earswitch Phase A | June 2023 | September 2024 |
| NCT06450418 | Not yet recruiting | Digital App for Speech & Health Monitoring | June 2024 | June 2026 | |
| NCT06315608 | Not yet recruiting | Phase 2 | MRG-001 in Patients With Amyotrophic Lateral Sclerosis | July 1, 2024 | December 1, 2024 |
| NCT06090448 | Not yet recruiting | N/A | Technical Evaluation of Earswitch Phase B | April 2024 | April 2025 |
| NCT02360891 | Recruiting | Study of Predictive Factors of Progression of Motor Neurone Disease | January 12, 2015 | January 2026 | |
| NCT04380649 | Recruiting | N/A | Development and Test of a Headset for BCI Until Obtaining an Efficient and Comfortable System That Can be Used in Daily Practice by ALS People | February 13, 2023 | February 2025 |
| NCT01900132 | Recruiting | N/A | Electrical Impedance Myography: Natural History Studies inNeuromuscular Disorders and Healthy Volunteers | June 20, 2013 | December 1, 2024 |
| NCT03362658 | Recruiting | Novel MRI Biomarkers for Monitoring Disease Progression in ALS | October 2016 | December 31, 2024 | |
| NCT02869048 | Recruiting | Amyotrophic Lateral Sclerosis and the Innate Immune System | June 2016 | June 2026 | |
| NCT02532244 | Recruiting | Genetics of Pediatric-Onset Motor Neuron and Neuromuscular Diseases | June 2015 | December 2025 | |
| NCT03827187 | Recruiting | N/A | Awareness Detection and Communication in Disorders of Consciousness | February 8, 2022 | August 2026 |
| NCT04695210 | Recruiting | N/A | Virtual Peer-to-peer Support Programme for Carers of MND | August 15, 2022 | December 31, 2024 |
| NCT04944940 | Recruiting | Clinical, Molecular and Imaging Biomarkers in Spinal and Bulbar Muscular Atrophy (SBMA) | October 25, 2021 | February 28, 2027 | |
| NCT06318598 | Recruiting | Biomarker-driven Phenotypic Dissection of Amyotrophic Lateral Sclerosis | April 11, 2023 | April 10, 2026 | |
| NCT05137665 | Recruiting | Target ALS Biomarker Study; Longitudinal Biofluids, Clinical Measures, and At Home Measures | January 1, 2021 | December 31, 2031 | |
| NCT05183152 | Recruiting | N/A | Non-invasive BCI-controlled Assistive Devices | June 16, 2021 | December 30, 2025 |
| NCT05354622 | Recruiting | Hereditary Spastic Paraplegia Genomic Sequencing Initiative (HSPseq) | April 25, 2022 | April 29, 2027 | |
| NCT05744310 | Recruiting | N/A | Effects of Long Term Ventilation Support on the Quality of Life of ALS Patients and Their Families | April 21, 2023 | August 21, 2032 |
| NCT06177431 | Recruiting | Phase 1 | An Open Label Extension Study of Monepantel in Individuals With Motor Neurone Disease | February 13, 2024 | April 1, 2025 |
| NCT06201650 | Recruiting | Neurofilament Light Chain in Amyotrophic Lateral Sclerosis | November 11, 2020 | December 31, 2024 | |
| NCT00004568 | Recruiting | Study of Inherited Neurological Disorders | February 18, 2000 | ||
| NCT06318585 | Recruiting | Creation of a Clinical Database for the Study of Phenotypic Variability in Motor Neuron Diseases | April 3, 2023 | December 31, 2026 | |
| NCT00537446 | Terminated | N/A | Effect of Noninvasive Ventilation on Lung Function in Amyotrophic Lateral Sclerosis | September 2007 | August 2012 |
| NCT04579666 | Terminated | Phase 2 | MERIDIAN: A Study to Evaluate the Efficacy and Safety of Pegcetacoplan in Adults With Amyotrophic Lateral Sclerosis (ALS) | September 30, 2020 | July 13, 2023 |
| NCT00718445 | Terminated | Pennsylvania Consortium: Clinical Database | March 2008 | December 2015 | |
| NCT00718107 | Terminated | Satisfaction Survey for Amyotrophic Lateral Sclerosis (ALS) Patients Comparing Rooms With and Without Assistive Technology | June 2005 | February 2012 | |
| NCT00718016 | Terminated | Assessment of the Cyberlink Control System for Use by the Amyotrophic Lateral Sclerosis (ALS) Patient | December 2004 | April 2009 | |
| NCT00718003 | Terminated | Noninvasive Examination of the Work of Breathing in Patients With Amyotrophic Lateral Sclerosis (ALS). | May 2005 | February 2013 | |
| NCT03196375 | Terminated | Phase 2 | A Study to Assess FLX-787 in Subjects With Motor Neuron Disease Experiencing Muscle Cramps. | July 28, 2017 | July 27, 2018 |
| NCT04240925 | Unknown status | N/A | Tolerability, Safety and Efficacy of Sigh Breaths During NIMV in Motor Neuron Disease | May 25, 2018 | December 31, 2022 |
| NCT04150809 | Unknown status | A Study to Explore the Role of Gut Flora in ALS | March 2, 2020 | July 2023 | |
| NCT03764384 | Unknown status | Validation Of Tidal/End -Tidal CO2 in ALS | August 20, 2018 | June 4, 2021 | |
| NCT03067857 | Unknown status | Phase 1/Phase 2 | Autologous Bone Marrow-Derived Stem Cell Therapy for Motor Neuron Disease | September 2016 | August 2019 |
| NCT03664206 | Withdrawn | Assessing Motor Neuron Disease Mechanisms by Threshold Tracking Transcranial Magnetic Stimulation and Magnetic Resonance Spectroscopy | February 16, 2018 | February 1, 2024 | |
| NCT03508453 | Withdrawn | Phase 2 | IC14 for Treatment of Amyotrophic Lateral Sclerosis | August 15, 2019 | December 15, 2021 |
- Disase is a (Disease Ontology)
- DOID:1289
- Cross Reference ID (Disease Ontology)
- ICD10CM:G12.2
- Cross Reference ID (Disease Ontology)
- ICD9CM:335.2
- Cross Reference ID (Disease Ontology)
- MESH:D016472
- Cross Reference ID (Disease Ontology)
- SNOMEDCT_US_2023_03_01:37340000
- Cross Reference ID (Disease Ontology)
- UMLS_CUI:C0085084
- MedGen concept unique identifier (MedGen Concept name)
- C0085084
- MedGen unique identifier (MedGen Concept name)
- 38785
- ICD10 preferred id (Insert disease from ICD10)
- D0005273
- ICD10 class code (Insert disease from ICD10)
- G12.2
- MeSH unique ID (MeSH (Medical Subject Headings))
- D016472