intrahepatic cholangiocarcinoma (Cancer)

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Information
Disease name
intrahepatic cholangiocarcinoma
Disease ID
DOID:4928
Description
"A cholangiocarcinoma that arises from the intrahepatic bile duct epithelium in any site of the intrahepatic biliary tree." [url:https\://www.dana-farber.org/intrahepatic-cholangiocarcinoma/]
Disease area statistics
Chromosome band
Gene symbol Chromosome Start Stop The number of variant
FOXL2 3 138,944,224 138,947,137 4
MDC1 6 30,699,807 30,717,281 2
TTK 6 80,004,649 80,042,527 2
SSBP2 5 81,412,804 81,751,097 2
FLT4 5 180,601,506 180,649,600 2
CBARP 19 1,228,287 1,238,005 2
EGFR 7 55,019,017 55,211,628 2
CEBPA 19 33,299,934 33,302,534 2
STK11 19 1,205,778 1,228,431 2
Annotation
Genes Mutation Description Source Links
NCT ID Status Phase Summary Start date Completion date
NCT05242822 Active, not recruiting Phase 1 A Study to Evaluate KIN-3248 in Participants With Advanced Tumors Harboring FGFR2 and//or FGFR3 Gene Alterations April 18, 2022 September 2026
NCT05220722 Active, not recruiting Phase 1/Phase 2 Pressure Enabled Delivery of SD-101 With Checkpoint Blockade for Primary Liver Tumors March 2, 2022 January 2025
NCT02834013 Active, not recruiting Phase 2 Nivolumab and Ipilimumab in Treating Patients With Rare Tumors January 30, 2017 May 1, 2026
NCT05239169 Active, not recruiting Phase 2 Immunotherapy With Durva and Treme With or Without Capecitabine in Adjuvant Treatment for Biliary Tract Cancer May 23, 2022 June 30, 2025
NCT01862315 Active, not recruiting Phase 2 Hepatic Arterial Infusion (HAI) With Floxuridine (FUDR) and Dexamethasone (Dex) Combined With Systemic Gemcitabine and Oxaliplatin in Patients With Unresectable Intrahepatic Cholangiocarcinoma (ICC) May 2013 May 2025
NCT05781958 Active, not recruiting Phase 2 Cadonilimab Combined With Gem/Cis as First Line Therapy in Patients With Advanced ICC November 24, 2022 December 1, 2024
NCT03781934 Active, not recruiting Phase 1/Phase 2 A Study to Evaluate MIV-818 in Patients With Liver Cancer Manifestations September 5, 2018 February 29, 2024
NCT04526106 Active, not recruiting Phase 1/Phase 2 REFOCUS: A First-in-Human Study of Highly Selective FGFR2 Inhibitor, RLY-4008, in Patients With ICC and Other Advanced Solid Tumors September 2, 2020 October 2024
NCT04087876 Available Expanded Access Use of Derazantinib for Advanced Intrahepatic Cholangiocarcinoma (iCCA) With FGFR Genomic Alterations
NCT03849469 Completed Phase 1 A Study of XmAb®22841 Monotherapy & in Combination w/ Pembrolizumab in Subjects w/ Selected Advanced Solid Tumors May 29, 2019 February 16, 2023
NCT01938729 Completed Phase 1 Hepatic Arterial Infusion With Floxuridine and Dexamethasone in Combination With Gemcitabine as Adjuvant Treatment After Resection of Intrahepatic Cholangiocarcinoma September 5, 2013 September 10, 2020
NCT01954745 Completed Phase 2 Cabozantinib (XL-184) Monotherapy for Advanced Cholangiocarcinoma September 2013 June 2016
NCT01347333 Completed N/A Stereotactic Body Radiotherapy for Liver Tumors September 2008 September 2016
NCT02273739 Completed Phase 1/Phase 2 Study of Orally Administered Enasidenib (AG-221) in Adults With Advanced Solid Tumors, Including Glioma, or Angioimmunoblastic T-cell Lymphoma, With an IDH2 Mutation December 8, 2014 June 3, 2016
NCT05930119 Completed Phase 1 HMPL-453 Food Effect and PPI Study in Healthy Volunteer Study March 17, 2023 August 28, 2023
NCT02762721 Completed Analysis of Oncogenes in Intrahepatic Cholangiocarcinoma or Mixed Hepatocellular-Cholangiocarcinoma in Tumor Tissue Samples June 6, 2016 April 6, 2017
NCT02807181 Completed Phase 2/Phase 3 SIRT Followed by CIS-GEM Chemotherapy Versus CIS-GEM Chemotherapy Alone as 1st Line Treatment of Patients With Unresectable Intrahepatic Cholangiocarcinoma January 2017 October 2022
NCT01668134 Completed Phase 1 Stereotactic Body Radiotherapy for Hepatocellular Carcinoma, and Intrahepatic Cholangiocarcinoma December 16, 2009 December 22, 2015
NCT03230318 Completed Phase 2 Derazantinib in Subjects With FGFR2 Gene Fusion-, Mutation- or Amplification- Positive Inoperable or Advanced Intrahepatic Cholangiocarcinoma September 28, 2017 October 25, 2022
NCT03251443 Completed Phase 2 A Study of Second-line Treatment With Apatinib in Patients With Advanced Intrahepatic Cholangiocarcinoma August 8, 2017 May 8, 2019
NCT03320980 Completed RALPPS in Patients With Hilar and Intrahepatic Cholangiocarcinoma September 15, 2014 October 1, 2017
NCT05489692 Completed HAIC Plus Targeted Therapy and/or PD-1 Inhibitors for Unresectable Intrahepatic Cholangiocarcinoma September 1, 2017 January 31, 2022
NCT01862276 Completed Role of Bile Duct Resection in Major Hepatectomy Due to Intrahepatic Cholangiocarcinoma March 2013 March 2014
NCT03796819 Completed N/A Routine Lymphadenectomy for Intrahepatic Cholangiocarcinoma January 10, 2019 December 1, 2021
NCT05342194 Not yet recruiting Phase 3 Toripalimab Plus Lenvatinib and Gemcitabine-based Chemotherapy in 1L Treatment of Advanced ICC: a Phase III Study October 1, 2022 May 31, 2027
NCT06313554 Not yet recruiting N/A Surufatinib Combined With Toripalimab and HAIC in the Treatment of Inoperable or Metastatic Intrahepatic Cholangiocarcinoma May 20, 2024 May 20, 2027
NCT05009953 Not yet recruiting Phase 2 Study of Irinotecan Liposome Injection in Patients With Advanced Biliary Tract Cancer September 2021 August 2024
NCT05896956 Not yet recruiting The Construction of Clinical Database and Multiomics Biobank Based on a Multicentral Prospective Cohort of Benign and Malignant Biliary Tract Diseases July 1, 2023 June 30, 2027
NCT05681949 Not yet recruiting N/A Therapeutic Assistance and Decision-making Algorithms in Hepatobiliary Tumor Boards November 2023 July 2025
NCT06406816 Not yet recruiting Early Phase 1 Neoantigen Vaccine Plus Capecitabine as Adjuvant Therapy for Intrahepatic Cholangiocarcinoma After Radical Resection May 2024 May 2026
NCT05422690 Not yet recruiting Phase 2 The Purpose of This Research Study is to See if Combining Gemcitabine, Cisplatin and Durvalumab Chemotherapy Treatments With a Direct Tumor Therapy Yittrium-90 (Y-90) Will Work Better Together to Shrink Tumors and Control Cancer May 15, 2024 September 30, 2028
NCT06134193 Not yet recruiting Phase 2 Combination Therapy of HAIC, Surufatinib and Tislelizumab for Unresectable or Metastatic Biliary Tract Cancer November 2023 June 2025
NCT06375642 Not yet recruiting Phase 2 A Single Arm, Single Centered Phase II Trial on the Combination of Adebrelimab, Surufatinib and Irinotecan Liposome-based HAIC in Advanced iCC May 10, 2024 August 31, 2026
NCT06417606 Not yet recruiting Phase 4 Lenvatinib and Adebrelimab Combined With GEMOX in the Perioperative Treatment of Potentially Resectable Intrahepatic Cholangiocarcinoma May 30, 2024 May 30, 2025
NCT05644743 Not yet recruiting Clinical Transformation of Organoid Model to Predict the Efficacy of GC in the Treatment of Intrahepatic Cholangiocarcinoma January 2023 December 2026
NCT05535647 Not yet recruiting Phase 2 Second Line Therapy for Advanced Intrahepatic Cholangiocarcinoma September 25, 2022 September 25, 2025
NCT06208462 Recruiting Phase 2 Neoadjuvant Therapy of HAIC(GEMOX) Combined With Adebrelimab and Lenvatinib for Resectable Intrahepatic Cholangiocarcinoma With High-risk Recurrence Factors March 25, 2024 January 2027
NCT02878473 Recruiting Phase 2 Liver Transplantation for Early Intrahepatic Cholangiocarcinoma April 5, 2018 January 2029
NCT02881554 Recruiting N/A Sulfur Colloid SPECT/CT in Measuring Liver Function in Patients With Primary or Metastatic Liver Cancer Undergoing Radiation Therapy or Surgery December 21, 2016 December 1, 2027
NCT03633773 Recruiting Phase 1/Phase 2 Safety and Efficacy Evaluation of MUC-1 CART in the Treatment of Intrahepatic Cholangiocarcinoma July 1, 2018 December 31, 2024
NCT04078230 Recruiting N/A Regional or Extend LymphAdenectomy During Resection of Intrahepatic Cholangiocarcinoma January 1, 2020 December 31, 2027
NCT04238637 Recruiting Phase 2 Immunotherapy Combined With Y-90 SIRT Therapy in Advanced Stage Intrahepatic Biliary Tract Cancer (BTC) November 1, 2019 December 2025
NCT04299581 Recruiting Phase 2 Cryoablation Combined With Anti-PD-1 Antibody in Patients With Advanced Intrahepatic Cholangiocarcinoma July 7, 2020 May 10, 2024
NCT04454905 Recruiting Phase 2 Camrelizumab in Combination With Apatinib in Advanced ICC: A Single-arm Phase II Study August 1, 2020 July 1, 2025
NCT05010681 Recruiting Phase 2 Lenvatinib Plus Sintilimab in Patients With Immune Checkpoint Inhibitor Previously Treated Advanced Liver Cancer August 24, 2021 August 20, 2025
NCT05174650 Recruiting Phase 2 Treatment of Atezolizumab and Derazantinib in Patients With Advanced iCCA With FGFR2 Fusions/Rearrangements April 20, 2022 August 2026
NCT05223816 Recruiting Phase 2 An Open-Label, Multiple-Center, Phase IIa/IIb Clinical Trial to Evaluate the Efficacy, Safety and Tolerability of VG161 as Monotherapy and in Combination With Nivolumab for Treatment of Patients With Hepatocellular Carcinoma or Intrahepatic Cholangiocarcinoma January 24, 2024 December 31, 2025
NCT05236699 Recruiting Phase 2 A Clinical Study of DEB-TACE Combined With Surufatinib and Camrelizumab in the Treatment of Inoperable or Metastatic ICC February 1, 2022 January 31, 2025
NCT05251662 Recruiting Phase 2 Sintilimab Combined With GEMOX ± IBI305 (Bevacizumab Biosimilar) Versus GEMOX in Advanced Intrahepatic Cholangiocarcinoma January 13, 2022 January 13, 2025
NCT05285358 Recruiting Phase 1 Pressurized Intraperitoneal Aerosolized Nab-Paclitaxel in Combination With Gemcitabine and Cisplatin for the Treatment of Biliary Tract Cancer Patients With Peritoneal Metastases September 19, 2022 October 11, 2028
NCT05290116 Recruiting Phase 2 HAIC Combined With Tislelizumab and Apatinib for Unresectable Intrahepatic Cholangiocarcinoma July 21, 2022 September 1, 2023
NCT05328167 Recruiting Phase 2 Contrast-Enhanced Ultrasound for the Prediction of Bile Duct Cancer Response to Radioembolization Treatment December 14, 2021 October 31, 2024
NCT05400902 Recruiting Phase 2 HAIC Combined With Sintilimab and Bevacizumab for Unresectable Intrahepatic Cholangiocarcinoma May 31, 2023 December 31, 2023
NCT05557578 Recruiting Phase 2 GOT Applied as Neoadjuvant Regimen for Patients of Resectable ICC With High-risk Factors of Recurrence May 5, 2023 December 2024
NCT05565794 Recruiting Phase 2 Pemigatinib After Curative Local Therapy in Advanced iCCA With FGFR2 Fusion/Rearrangements November 11, 2022 November 2026
NCT05672537 Recruiting Phase 2 Durvalumab Combined With GemCis Neoadjuvant Therapy of Resectable Intrahepatic Cholangiocarcinoma With High Recurrence Risk January 20, 2023 December 31, 2025
NCT05678218 Recruiting Preoperative Evaluation of Lymph Nodes of Cholangiocarcinoma September 5, 2022 February 1, 2026
NCT05712356 Recruiting Phase 2 A Study of LSTA1 When Added to Standard of Care Versus Standard of Care Alone in Patients With Advanced Solid Tumors August 24, 2023 December 2025
NCT05913661 Recruiting Phase 2 Pemigatinib Combined With PD-1 Inhibitor in Unresectable or Metastatic Intrahepatic Cholangiocarcinoma July 2023 November 2024
NCT06098547 Recruiting N/A LIver Transplantation for Non-Resectable Intrahepatic CholAngiocarcinoma (LIRICA) January 15, 2024 November 1, 2033
NCT06101277 Recruiting N/A Locally ablatIVe thErapy for oLigo-progressive gastrOintestiNal maliGnancies (LIVELONG) October 5, 2023 January 5, 2031
NCT06140134 Recruiting Liver Transplantation in Intrahepatic Cholangiocarcinoma December 15, 2023 November 2029
NCT06160752 Recruiting Phase 1 Safety and Anti-Tumor Activity of TYRA-200 in Advanced Cholangiocarcinoma With Activating FGFR2 Gene Alterations November 22, 2023 September 2027
NCT06239532 Recruiting Phase 2 HAIC Sequential TAE Combined With Tislelizumab and Surufatinib in Unresectable Intrahepatic Cholangiocarcinoma September 27, 2022 December 31, 2025
NCT06290739 Recruiting A Machine-learning Model to Predict Lymph Node Metastasis of Intrahepatic Cholangiocarcinoma February 7, 2024 March 27, 2024
NCT06296563 Recruiting Phase 2 Perioperative Treatment of Resectable Intrahepatic Cholangiocarcinoma With the Combination of Adebrelimab and Apatinib and HAIC March 1, 2024 March 1, 2029
NCT06298968 Recruiting Phase 2 Combined Therapy Using Gemcitabine and Cisplatin Chemotherapy, Lenvatinib and Adebrelimab for Patients With Advanced and Unresectable Intrahepatic Cholangiocarcinoma February 25, 2024 February 25, 2027
NCT06313203 Recruiting Phase 2 HAI-Floxuridine, or SIRT, Combined With Gemox For Patients With Intra-Hepatic Cholangiocarcinoma Not Amenable to Resection (TOMCAT) February 13, 2024 January 2034
NCT06335927 Recruiting Phase 2 HAIC Combined With Cadonilimab and Regorafenib as 2nd-line Treatment for ICC May 11, 2023 May 10, 2026
NCT06342414 Recruiting An Exosome-Based Liquid Biopsy for the Differential Diagnosis of Primary Liver Cancer March 15, 2024 March 15, 2025
NCT06370663 Recruiting Phase 2 First-line Treatment for Unresectable Locally Advanced Distal Cholangiocarcinoma Combining Radiotherapy and HAIC April 1, 2024 April 1, 2026
NCT06375915 Recruiting Phase 2 Precision Medicine in Patients With Unresectable CholAngiocarcinoma: RadioEmbolization and Combined Biological Therapy May 1, 2024 January 2026
NCT04556214 Recruiting N/A Liver Transplantation for Non-Resectable Intrahepatic Cholangiocarcinoma: a Prospective Exploratory Trial (TESLA Trial) June 1, 2020 May 31, 2035
NCT04561453 Recruiting Feasibility Study of Multi-Platform Profiling of Resected Biliary Tract Cancer July 8, 2020 July 1, 2025
NCT04669496 Recruiting Phase 2/Phase 3 Phase II-III Clinical Trial of PD1 Antibody (Toripalimab), Lenvatinib and GEMOX Neoadjuvant Treatment for Resectable Intrahepatic Cholangiocarcinoma With High-risk Recurrence Factors January 20, 2021 December 2024
NCT04684862 Recruiting N/A Infusion System for Hepatic Cancer February 8, 2021 July 2029
NCT04891289 Recruiting Phase 2 Gemcitabine and Oxaliplatin Chemotherapy With or Without a Floxuridine and Dexamethasone Pump in People With Cholangiocarcinoma That Cannot Be Removed With Surgery May 7, 2021 May 2025
NCT04954781 Recruiting Phase 2 TACE Combined With Tislelizumab in Patients With Advanced Intrahepatic Cholangiocarcinoma July 14, 2021 July 15, 2025
NCT04961970 Recruiting Phase 3 HAIC With FOLFOX Versus Systemic Chemotherapy With GP for Unresectable ICC July 9, 2021 July 9, 2025
NCT05010668 Recruiting Phase 2 Cryoablation Combined With Sintilimab Plus Lenvatinib in Patients With Advanced Intrahepatic Cholangiocarcinoma August 24, 2021 August 16, 2024
NCT03779100 Suspended Phase 2 Lenvatinib Plus PD-1 Antibody for Unresectable ICC December 17, 2018 December 31, 2019
NCT02415036 Terminated Phase 2 Melphalan for Use With the Hepatic Delivery System Treatment in Patients With Unresectable Hepatocellular Carcinoma or Intra Hepatic Cholangiocarcinoma June 2014 December 2018
NCT02254681 Terminated Phase 2 Low-Dose Radiation Therapy to the Whole Liver With Gemcitabine and Cisplatin in IHC September 2014 September 2016
NCT02526771 Unknown status N/A Conventional or Unconventional Lymph Node Dissection During Resection of Intrahepatic Cholangiocarcinoma August 2015 December 2017
NCT02512692 Unknown status N/A 90Y Transarterial Radioembolization (TARE) Plus Gemcitabine and Cisplatin in Unresectable Intrahepatic Cholangiocarcinoma July 21, 2015 August 31, 2022
NCT03345303 Unknown status Phase 3 Bortezomib in Intrahepatic Cholangiocellular Carcinoma January 2017 December 2022
NCT05327907 Unknown status Establishment of Scoring Model for Early and Differential Diagnosis of Intrahepatic Cholangiocarcinoma November 22, 2020 May 22, 2023
NCT03086993 Unknown status Phase 2/Phase 3 Percutaneous Hepatic Perfusion vs. Cisplatin/Gemcitabine in Patients With Intrahepatic Cholangiocarcinoma April 10, 2018 May 2023
NCT04961788 Unknown status Phase 2 Anti-PD1 Antibody Toripalimab Combined With Gemox as First-line Therapy in Late-stage Intrahepatic Cholangiocarcinoma July 1, 2021 December 31, 2022
NCT01914289 Unknown status N/A Prognosis of Resection and Radiotherapy in the Treatment of Intrahepatic Cholangiocarcinoma Patients January 2011 April 2016
NCT02238613 Unknown status N/A Radioactive Stents for Treatment of Unresectable Biliary Tract Cancer August 2014 June 2017
NCT02184871 Unknown status Next Generation Sequencing in Intrahepatic Cholangiocarcinoma May 2014 May 2017
NCT03771846 Unknown status Phase 3 HAIC Versus Systemic Chemotherapy for Unresectable ICC August 1, 2018 August 1, 2022
NCT04295317 Unknown status Phase 2 PD-1 Antibody (SHR-1210) Plus Capecitabine in Patients With Intrahepatic Cholangiocarcinoma After Surgery August 1, 2020 February 28, 2024
NCT01917370 Unknown status VEGF Signaling Promotes Cell Growth and Metastasis in Intrahepatic Cholangiocarcinoma in a VEGF Receptor Mediated Pathway October 2012 December 2014
NCT02588755 Unknown status N/A TACE Plus Tegafur Versus TACE for Intrahepatic Cholangiocarcinoma After Curative Resection December 2015 December 2017
NCT05240040 Unknown status Treat Primary and Metastatic Liver Tumors April 26, 2016 May 2022
NCT03521219 Unknown status Phase 2 A Study of Second-line Treatment With Apatinib for Advanced Intrahepatic Cholangiocarcinoma February 7, 2018 November 2019
NCT05247996 Unknown status N/A TACE Combined With "Target Immune" Therapy for First-line Treatment in the Treatment of Intrahepatic Cholangiocarcinoma March 1, 2022 December 31, 2023
NCT04834674 Unknown status Phase 2 DEB-TACE Combined With Apatinib and PD-1 for the Treatment of Intrahepatic Cholangiocarcinoma May 1, 2021 April 30, 2024
NCT05019677 Withdrawn Phase 2 GP Chemotherapy in Combination With Tislelizumab and Ociperlimab as First-line Treatment in Advanced BTC September 1, 2021 December 1, 2024
NCT04546828 Withdrawn Phase 2 A Single-arm Study of Gemcitabine, Cisplatin, and Nab-Paclitaxel as Neoadjuvant Therapy for Resectable Oncologically High-Risk IHCC in Korea February 1, 2021 August 18, 2021
NCT04479904 Withdrawn Phase 2 A Trial of Famitinib in Patients With Failure of First-Line Treatment For Intrahepatic Cholangiocarcinoma August 10, 2020 February 10, 2022
NCT03081039 Withdrawn Phase 3 A Study of Cisplatin or Carboplatin With Gemcitabine Versus Gemcitabine Alone as Adjuvant Therapy in Patients With Resected or Ablation Intra-Hepatic Cholangiocarcinoma August 21, 2017 December 31, 2022
NCT04511793 Withdrawn N/A Hepatic Artery Infusion (HAI) Program at Duke University December 11, 2020 December 31, 2022
NCT03801499 Withdrawn Phase 2 Lenvatinib for Unresectable Intrahepatic Cholangiocarcinoma September 1, 2018 December 2019
NCT01775280 Withdrawn Phase 2 Response of Hepatic Tumors to Radioembolization October 2012 October 2015
NCT05292443 Withdrawn Therapeutic ResistAnce and Clonal Evolution Assessed With Liquid Biopsy in ICIs Treated Primary Liver Cancer December 20, 2021 March 17, 2023
Disase is a (Disease Ontology)
DOID:4947
Cross Reference ID (Disease Ontology)
GARD:6042
Cross Reference ID (Disease Ontology)
ICD10CM:C22.1
Cross Reference ID (Disease Ontology)
MESH:D018281
Cross Reference ID (Disease Ontology)
NCI:C35417
Cross Reference ID (Disease Ontology)
SNOMEDCT_US_2023_03_01:1260050006
Cross Reference ID (Disease Ontology)
UMLS_CUI:C0345905
Exact Synonym (Disease Ontology)
Intrahepatic bile duct carcinoma
Exact Synonym (Disease Ontology)
peripheral Cholangiocarcinoma