chordoma (Cancer)
Information
- Disease name
- chordoma
- Disease ID
- DOID:3302
- Description
- "A notochordal cancer that derives_from cellular remnants of the notochord." [url:http\://en.wikipedia.org/wiki/Chordoma]
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
| Genes | Mutation | Description | Source | Links |
|---|
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT02834013 | Active, not recruiting | Phase 2 | Nivolumab and Ipilimumab in Treating Patients With Rare Tumors | January 30, 2017 | May 1, 2026 |
| NCT01407198 | Active, not recruiting | Phase 1 | Nilotinib With Radiation for High Risk Chordoma | August 2011 | December 2025 |
| NCT02989636 | Active, not recruiting | Phase 1 | Nivolumab With or Without Stereotactic Radiosurgery in Treating Patients With Recurrent, Advanced, or Metastatic Chordoma | March 10, 2017 | November 2026 |
| NCT04246671 | Active, not recruiting | Phase 1 | TAEK-VAC-HerBy Vaccine for Brachyury and HER2 Expressing Cancer | August 10, 2020 | June 2026 |
| NCT00496119 | Active, not recruiting | Phase 2 | Proton Beam Therapy for Chordoma Patients | September 18, 2006 | December 31, 2024 |
| NCT04091295 | Available | BLESSED: Expanded Access for DeltaRex-G for Advanced Pancreatic Cancer, Sarcoma and Carcinoma of Breast | |||
| NCT00592748 | Completed | Phase 1/Phase 2 | Charged Particle RT for Chordomas and Chondrosarcomas of the Base of Skull or Cervical Spine | June 1999 | May 2015 |
| NCT00713037 | Completed | N/A | Hypoxia-positron Emission Tomography (PET) and Intensity Modulated Proton Therapy (IMPT) Dose Painting in Patients With Chordomas | June 2008 | June 2016 |
| NCT00919269 | Completed | Collecting and Storing Tissue, Blood, and Bone Marrow Samples From Patients With Rhabdomyosarcoma or Other Soft Tissue Sarcoma | March 15, 1999 | September 30, 2023 | |
| NCT01347307 | Completed | N/A | Stereotactic Body Radiotherapy for Spine Tumors | September 2008 | September 2017 |
| NCT01567046 | Completed | Studying Genes in Tissue Samples From Younger and Adolescent Patients With Soft Tissue Sarcomas | May 2016 | May 2016 | |
| NCT02383498 | Completed | Phase 2 | QUILT-3.011 Phase 2 Yeast-Brachyury Vaccine Chordoma | May 1, 2015 | September 1, 2019 |
| NCT02520128 | Completed | N/A | A Study of IMRT in Primary Bone and Soft Tissue Sarcoma | March 2016 | June 30, 2020 |
| NCT00150072 | Completed | Phase 2 | Efficacy and Safety of Imatinib in Chordoma | October 2004 | April 2008 |
| NCT03955042 | Completed | Phase 1 | Pemetrexed for the Treatment of Chordoma | September 6, 2019 | January 18, 2023 |
| NCT03110744 | Completed | Phase 2 | CDK4/6 Inhibition in Locally Advanced/Metastatic Chordoma | December 15, 2017 | December 22, 2022 |
| NCT00341627 | Completed | Genetic Aspects of Chordoma: A Collaboration With SEER Registries to Identify Chordoma Families | February 1, 1999 | July 6, 2020 | |
| NCT03190174 | Completed | Phase 1/Phase 2 | Nivolumab (Opdivo®) Plus ABI-009 (Nab-rapamycin) for Advanced Sarcoma and Certain Cancers | August 24, 2017 | December 2, 2021 |
| NCT03595228 | Completed | Phase 2 | BN Brachyury and Radiation in Chordoma | October 31, 2018 | January 25, 2022 |
| NCT03623854 | Completed | Phase 2 | Nivolumab and Relatlimab in Treating Participants With Advanced Chordoma | April 3, 2019 | September 28, 2023 |
| NCT04486820 | Completed | Immunohistochemical Study of Chordomas to Improve Their Diagnosis and Prognosis Care | April 1, 2020 | July 1, 2020 | |
| NCT00410670 | Completed | Chordoma Family Study | August 1, 2003 | December 29, 2017 | |
| NCT00464620 | Completed | Phase 2 | Trial of Dasatinib in Advanced Sarcomas | May 2007 | May 2017 |
| NCT06140732 | Recruiting | Phase 2 | Apatinib Combined With Camrelizumab in Treating Participants With Advanced Chordoma | October 30, 2023 | January 31, 2026 |
| NCT02986516 | Recruiting | N/A | Sacral Chordoma: Surgery Versus Definitive Radiation Therapy in Primary Localized Disease | March 16, 2017 | September 2024 |
| NCT03242382 | Recruiting | Phase 2 | Trial of Palbociclib in Second Line of Advanced Sarcomas With CDK4 Overexpression. | March 31, 2017 | September 30, 2024 |
| NCT04087902 | Recruiting | Long-Term Longitudinal QoL in Patients Undergoing EEA | July 16, 2019 | December 31, 2025 | |
| NCT04832620 | Recruiting | Image Assisted Optimization of Proton Radiation Therapy in Chordomas and Chondrosarcomas | February 2, 2021 | December 2027 | |
| NCT05033288 | Recruiting | Comparing Carbon Ion Therapy, Surgery, and Proton Therapy for Management of Pelvic Sarcomas Involving the Bone | January 20, 2022 | August 30, 2028 | |
| NCT05041127 | Recruiting | Phase 2 | Cetuximab for the Treatment of Advanced Unresectable or Metastatic Chordoma | May 27, 2022 | September 1, 2024 |
| NCT05407441 | Recruiting | Phase 1/Phase 2 | Tazemetostat+Nivo/Ipi in INI1-Neg/SMARCA4-Def Tumors | August 10, 2023 | February 1, 2029 |
| NCT05861245 | Recruiting | N/A | Hypofractionated Protontherapy in Chordomas and Chondrosarcomas of the Skull Base | May 24, 2023 | May 24, 2033 |
| NCT06029218 | Recruiting | N/A | Analysis of the Toxicity and Efficacy of Daily 1 vs 2 Beam Proton Therapy | September 13, 2023 | October 1, 2031 |
| NCT03910465 | Recruiting | Children and Adults With Chordoma | April 16, 2019 | December 31, 2029 | |
| NCT00003926 | Terminated | Phase 1 | Amifostine to Protect From Side Effects of PSCT in Treating Patients With Solid Tumors | November 1998 | August 2003 |
| NCT00349024 | Unknown status | N/A | Polyvinylpyrrolidone-Sodium Hyaluronate Gel in Reducing Pain From Oral Mucositis in Young Patients With Cancer | July 2005 | |
| NCT03083678 | Unknown status | Phase 2 | Afatinib in Locally Advanced and Metastatic Chordoma | June 21, 2018 | October 1, 2023 |
| NCT04042597 | Unknown status | Phase 2 | Anlotinib Hydrochloride Versus Imatinib Mesylate in Locally Advanced, Unresectable or Metastatic Chordoma | July 18, 2019 | December 31, 2021 |
| NCT01175109 | Unknown status | Phase 1 | Study of Imatinib, a Platelet-derived Growth Factor Receptor Inhibitor, and LBH589, a Histone Deacetylase Inhibitor, in the Treatment of Newly Diagnosed and Recurrent Chordoma | October 2011 | December 2013 |
| NCT01182779 | Unknown status | Phase 3 | Trial of Proton Versus Carbon Ion Radiation Therapy in Patients With Chordoma of the Skull Base | July 2010 | August 2023 |
| NCT03647423 | Withdrawn | Phase 1/Phase 2 | QUILT-3.091 NANT Chordoma Vaccine vs Radiation in Subjects With Unresectable Chordoma. | August 31, 2018 | August 30, 2022 |
- Disase is a (Disease Ontology)
- DOID:3303
- Cross Reference ID (Disease Ontology)
- GARD:1303
- Cross Reference ID (Disease Ontology)
- ICDO:9370/3
- Cross Reference ID (Disease Ontology)
- MESH:D002817
- Cross Reference ID (Disease Ontology)
- NCI:C2947
- Cross Reference ID (Disease Ontology)
- SNOMEDCT_US_2023_03_01:50007008
- Cross Reference ID (Disease Ontology)
- UMLS_CUI:C0008487
- Exact Synonym (Disease Ontology)
- notochordoma
- HPO Human Phenotype ID (Human Phenotype Ontology)
- HP:0010762
- OrphaNumber from OrphaNet (Orphanet)
- 178
- MeSH unique ID (MeSH (Medical Subject Headings))
- D002817