Disase Detail : MGeND

Information

Disease name: Werner syndrome
Disease ID: DOID:5688
Description: "A progeroid syndrome characterized by premature aging and age-related phenotypes such as atherosclerosis, arteriosclerosis, cataracts, osteoporosis, soft tissue calcification, premature thinning, graying, and loss of hair, as well as a high incidence of some types of cancers and that has_material_basis_in mutations in the WRN gene, on chromosome 8." [url:https\://en.wikipedia.org/wiki/Werner_syndrome, url:https\://www.ncbi.nlm.nih.gov/pubmed/15946710, url:https\://www.ncbi.nlm.nih.gov/pubmed/9288107]

Disease area statistics

Chromosome band

Gene symbol	Chromosome	Start	Stop	The number of variant
WRN	8	31,033,810	31,176,138	52

Annotation

Genes	Mutation	Description	Source	Links

NCT ID	Status	Phase	Summary	Start date	Completion date
NCT04512963	Completed	Phase 1	Phase I Study of Progerinin in Healthy Volunteers	August 24, 2020	July 27, 2021
NCT05847179	Not yet recruiting	Phase 2	Phase 2, Open-Label Study to Evaluate the Safety and Tolerability of Progerinin in Werner Syndrome	January 1, 2025	January 1, 2027

Werner syndrome