anaplastic astrocytoma (Cancer)

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Information
Disease name
anaplastic astrocytoma
Disease ID
DOID:3078
Description
"A malignant astrocytoma that is characterized by cells with regular, round to oval nuclei." [url:http\://en.wikipedia.org/wiki/Anaplastic_astrocytoma, url:http\://www.cancer.gov/dictionary?CdrID=45591]
Disease area statistics
Chromosome band
Gene symbol Chromosome Start Stop The number of variant
IDH2 15 90,083,045 90,102,468 4
Annotation
Genes Mutation Description Source Links
NCT ID Status Phase Summary Start date Completion date
NCT05934630 Active, not recruiting Testing Cerebrospinal Fluid for Cell-free Tumor DNA in Children, Adolescents, and Young Adults With Brain Tumors July 12, 2023 July 12, 2028
NCT02101905 Active, not recruiting Phase 1 Lapatinib Ditosylate Before Surgery in Treating Patients With Recurrent High-Grade Glioma March 13, 2014 October 19, 2024
NCT03180502 Active, not recruiting Phase 2 Proton Beam or Intensity-Modulated Radiation Therapy in Preserving Brain Function in Patients With IDH Mutant Grade II or III Glioma August 2, 2017 January 2030
NCT03581292 Active, not recruiting Phase 2 Veliparib, Radiation Therapy, and Temozolomide in Treating Patients With Newly Diagnosed Malignant Glioma Without H3 K27M or BRAFV600 Mutations November 6, 2018 September 22, 2024
NCT03561207 Active, not recruiting 3D Prediction of Patient-Specific Response June 11, 2018 December 2024
NCT01204684 Active, not recruiting Phase 2 Dendritic Cell Vaccine for Patients With Brain Tumors October 8, 2010 January 31, 2026
NCT04295759 Active, not recruiting Phase 1 INCB7839 in Treating Children With Recurrent/Progressive High-Grade Gliomas July 27, 2020 June 30, 2024
NCT00089427 Completed Phase 1 IL13-PE38QQR Infusion After Tumor Resection, Followed by Radiation Therapy With or Without Temozolomide in Patients With Newly Diagnosed Malignant Glioma July 2004
NCT00100802 Completed Phase 2 Radiation Therapy, Temozolomide, and Lomustine in Treating Young Patients With Newly Diagnosed Gliomas March 21, 2005 June 30, 2017
NCT00115440 Completed Phase 1/Phase 2 BNCT to Treat Glioma That Has Progressed Following Radiotherapy March 2001 January 2009
NCT00301418 Completed Phase 1/Phase 2 Oral Tarceva Study for Recurrent/Residual Glioblastoma Multiforme and Anaplastic Astrocytoma March 2006 May 2014
NCT00390299 Completed Phase 1 Viral Therapy in Treating Patients With Recurrent Glioblastoma Multiforme October 23, 2006 November 30, 2019
NCT00409214 Completed Phase 2 Phase IIa Safety and Light Dose-escalation Study in Patients With Primary or Recurrent/High-grade Glioma Using the Litx™ System to Confirm the Zone of Tumor Destruction During the Intraoperative Treatment of Glioma November 2006
NCT00430911 Completed Phase 3 Radiotherapy for Malignant Astrocytomas in the Elderly February 2001
NCT00431561 Completed Phase 2 Phase IIb Clinical Trial With TGF-β2 Antisense Compound AP 12009 for Recurrent or Refractory High-grade Glioma April 2003 March 2009
NCT00589875 Completed Phase 2 Phase 2a Study of CAN-2409 With Standard Radiation Therapy for Malignant Glioma March 2007 August 2016
NCT00606008 Completed Phase 2 A Phase II Trial of Sutent (Sunitinib; SU011248) for Recurrent Anaplastic Astrocytoma and Glioblastoma March 2007 August 2012
NCT00610571 Completed Phase 1 Ph I Oral Topotecan and Temozolomide for Patients With Malignant Gliomas April 2004 April 2012
NCT00612651 Completed Phase 1 PH I Addition of Farnesyl Transferase Inhibitor to Temozolomide for Pts w Gr 3 & 4 Malignant Gliomas October 2005 June 2011
NCT00667394 Completed Phase 2 Tandutinib Plus Bevacizumab to Treat Recurrent Brain Tumors April 2008 July 2011
NCT00717210 Completed Phase 3 Randomized Phase III Study of Sequential Radiochemotherapy of Anaplastic Glioma With PCV or Temozolomide June 1999 March 2008
NCT00734682 Completed Phase 1 A Phase I Trial of Nanoliposomal CPT-11 (NL CPT-11) in Patients With Recurrent High-Grade Gliomas August 2008 December 2014
NCT00751270 Completed Phase 1 Phase 1b Study of AdV-tk + Valacyclovir Combined With Radiation Therapy for Malignant Gliomas November 2005 January 2011
NCT00003470 Completed Phase 2 Antineoplaston Therapy in Treating Patients With Anaplastic Astrocytoma March 1996 December 2009
NCT00004688 Completed Phase 2 Phase II Study of Carmustine, Streptozocin, and Mercaptopurine for Refractory or Recurrent Brain Neoplasms August 1996 July 1998
NCT00024557 Completed Phase 1 Histologic Effect/Safety of Pre/Post-Operative IL13-PE38QQR in Recurrent Resectable Supratentorial Malignant Glioma Patients June 2001 July 2007
NCT00024570 Completed Phase 1/Phase 2 Interstitial Infusion of IL13-PE38QQR Cytotoxin in Recurrent Malignant Glioma November 2000 July 2007
NCT00031083 Completed Phase 1 Dose Escalation Study to Determine the Safety of IFN-Beta Gene Transfer in the Treatment of Grade III & Grade IV Gliomas April 2, 2002 October 10, 2003
NCT00041587 Completed Phase 1/Phase 2 Pre-operative IL13-PE38QQR in Patients With Recurrent or Progressive Malignant Glioma July 2002 July 2007
NCT00064779 Completed Phase 1 Imaging Study of the Distribution of IL13-PE38QQR Infused Before and After Surgery in Adult Patients With Recurrent Malignant Glioma July 2003 July 2007
NCT00879437 Completed Phase 2 Valproic Acid, Radiation, and Bevacizumab in Children With High Grade Gliomas or Diffuse Intrinsic Pontine Glioma September 1, 2009 October 2, 2017
NCT00884416 Completed Phase 1 Sorafenib in Newly Diagnosed High Grade Glioma March 2009 March 2012
NCT00968240 Completed Phase 1 Super-Selective Intraarterial Intracranial Infusion of Avastin (Bevacizumab) July 2009 January 2014
NCT00995007 Completed Phase 2 A Randomized Phase II Trial of Vandetanib (ZD6474) in Combination With Carboplatin Versus Carboplatin Alone Followed by Vandetanib Alone in Adults With Recurrent High-Grade Gliomas September 2009 December 2015
NCT01082926 Completed Phase 1 Phase I Study of Cellular Immunotherapy for Recurrent/Refractory Malignant Glioma Using Intratumoral Infusions of GRm13Z40-2, An Allogeneic CD8+ Cytolitic T-Cell Line Genetically Modified to Express the IL 13-Zetakine and HyTK and to be Resistant to Glucocorticoids, in Combination With Interleukin-2 May 2010 September 2013
NCT01144247 Completed Phase 1 Cellular Immunotherapy Study for Brain Cancer July 2010 July 2015
NCT01151670 Completed Phase 1 Pioglitazone Hydrochloride in Preventing Radiation-Induced Cognitive Dysfunction in Treating Patients With Brain Tumors August 2010 August 2014
NCT01156584 Completed Phase 1 A Study of a Retroviral Replicating Vector Combined With a Prodrug Administered to Patients With Recurrent Malignant Glioma July 2010 August 18, 2016
NCT01171469 Completed Phase 1 Vaccination With Dendritic Cells Loaded With Brain Tumor Stem Cells for Progressive Malignant Brain Tumor September 2010 June 2012
NCT01180816 Completed Phase 1 Super-Selective Intraarterial Cerebral Infusion Of Temozolomide (Temodar) For Treatment Of Newly Diagnosed GBM And AA August 2010 August 11, 2020
NCT01189266 Completed Phase 1/Phase 2 Vorinostat and Radiation Therapy Followed by Maintenance Therapy With Vorinostat in Treating Younger Patients With Newly Diagnosed Diffuse Intrinsic Pontine Glioma August 9, 2010 September 30, 2021
NCT01222754 Completed Phase 1 Lenalidomide and Radiation Therapy in High Grade Gliomas or Diffuse Intrinsic Pontine Gliomas November 23, 2010 April 17, 2019
NCT01238237 Completed Phase 1 Super-Selective Intraarterial Cerebral Infusion of Cetuximab (Erbitux) for Treatment of Relapsed/Refractory GBM and AA December 2009 January 2016
NCT01250470 Completed Phase 1 Vaccine Therapy and Sargramostim in Treating Patients With Malignant Glioma September 5, 2012 May 29, 2014
NCT01316809 Completed Phase 1 AZD8055 for Adults With Recurrent Gliomas March 4, 2011 April 4, 2016
NCT01380782 Completed Phase 2 BIBF 1120 for Recurrent High-Grade Gliomas May 2012 July 2014
NCT01470794 Completed Phase 1 Study of a Retroviral Replicating Vector Combined With a Prodrug to Treat Patients Undergoing Surgery for a Recurrent Malignant Brain Tumor February 2012 April 12, 2016
NCT01502241 Completed Phase 3 Phase III Trial of Primary Radio- or Chemotherapy in Malignant Astrocytoma of the Elderly January 2005 November 2011
NCT01514201 Completed Phase 1/Phase 2 Veliparib, Radiation Therapy, and Temozolomide in Treating Younger Patients With Newly Diagnosed Diffuse Pontine Gliomas February 1, 2012 March 28, 2018
NCT01522820 Completed Phase 1 Vaccine Therapy With or Without Sirolimus in Treating Patients With NY-ESO-1 Expressing Solid Tumors March 2012 July 2016
NCT01808820 Completed Phase 1 Dendritic Cell (DC) Vaccine for Malignant Glioma and Glioblastoma August 21, 2013 July 16, 2022
NCT01922076 Completed Phase 1 Adavosertib and Local Radiation Therapy in Treating Children With Newly Diagnosed Diffuse Intrinsic Pontine Gliomas September 3, 2013 September 30, 2022
NCT01967758 Completed Phase 1 Phase I Study of Safety and Immunogenicity of ADU-623 January 8, 2014 August 15, 2018
NCT01975116 Completed Phase 1 p28 in Treating Younger Patients With Recurrent or Progressive Central Nervous System Tumors August 2013 April 2015
NCT01985256 Completed Phase 1 Study of a Retroviral Replicating Vector Given Intravenously to Patients Undergoing Surgery for Recurrent Brain Tumor February 2014 March 3, 2016
NCT02022384 Completed Immunophenotyping From Blood of Patients With Malignant Gliomas December 2013 December 31, 2022
NCT02238496 Completed Phase 1 Perifosine and Torisel (Temsirolimus) for Recurrent/Progressive Malignant Gliomas December 8, 2014 February 14, 2021
NCT02457845 Completed Phase 1 HSV G207 Alone or With a Single Radiation Dose in Children With Progressive or Recurrent Supratentorial Brain Tumors May 2016 January 2024
NCT02490930 Completed Early Phase 1 A Safety Study of Fingolimod With Radiation and Temozolomide in Newly Diagnosed High Grade Glioma July 2015 September 2017
NCT02644291 Completed Phase 1 Phase I Study of Mebendazole Therapy for Recurrent/Progressive Pediatric Brain Tumors May 2016 June 9, 2022
NCT02684058 Completed Phase 2 Study of Efficacy and Safety of Dabrafenib in Combination With Trametinib in Pediatric Patients With BRAF V600 Mutation Positive LGG or Relapsed or Refractory HGG Tumors December 28, 2017 April 28, 2023
NCT03043391 Completed Phase 1 Phase 1b Study PVSRIPO for Recurrent Malignant Glioma in Children November 7, 2017 March 23, 2022
NCT03072134 Completed Phase 1 Neural Stem Cell Based Virotherapy of Newly Diagnosed Malignant Glioma April 24, 2017 July 1, 2021
NCT03355794 Completed Phase 1 A Study of Ribociclib and Everolimus Following Radiation Therapy in Children With Newly Diagnosed Non-biopsied Diffuse Pontine Gliomas (DIPG) and RB+ Biopsied DIPG and High Grade Gliomas (HGG) November 14, 2017 July 31, 2022
NCT03434262 Completed Phase 1 SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors March 5, 2018 May 24, 2024
NCT05039346 Completed Quality of Life and Patient Needs in Advanced High Grade Gliomas February 11, 2012 January 30, 2023
NCT02755987 No longer available Expanded Access to ANG1005 for Individual Patients
NCT06333899 Not yet recruiting Early Phase 1 Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion September 1, 2024 September 1, 2034
NCT06241391 Not yet recruiting N/A Ga-68 Prostate Specific Membrane Antigen PET/CT in Gliomas February 2024 February 2025
NCT05839379 Not yet recruiting Targeted Pediatric High-Grade Glioma Therapy May 30, 2024 May 30, 2034
NCT05843253 Not yet recruiting Phase 2 Study of Ribociclib and Everolimus in HGG and DIPG May 30, 2024 May 30, 2034
NCT03975829 Recruiting Phase 4 Pediatric Long-Term Follow-up and Rollover Study November 4, 2019 May 29, 2026
NCT06264388 Recruiting Phase 2 DB107-Retroviral Replicating Vector (RRV) Combined With DB107-Flucytosine (FC) in Patients With Recurrent Glioblastoma or Anaplastic Astrocytoma May 1, 2024 May 1, 2034
NCT01269853 Recruiting Phase 1/Phase 2 Repeated Super-selective Intraarterial Cerebral Infusion of Bevacizumab (Avastin) for Treatment of Relapsed GBM and AA October 2010 October 2026
NCT05698524 Recruiting Phase 1 A Study of Temodar With Abexinostat (PCI-24781) for Patients With Recurrent Glioma June 26, 2023 June 2027
NCT03603405 Recruiting Phase 1/Phase 2 HSV-tk and XRT and Chemotherapy for Newly Diagnosed GBM February 28, 2018 December 31, 2025
NCT03919071 Recruiting Phase 2 Dabrafenib Combined With Trametinib After Radiation Therapy in Treating Patients With Newly-Diagnosed High-Grade Glioma February 20, 2020 September 30, 2027
NCT01837862 Recruiting Phase 1/Phase 2 A Phase I Study of Mebendazole for the Treatment of Pediatric Gliomas October 22, 2013 April 2025
NCT04541082 Recruiting Phase 1 Phase I Study of Oral ONC206 in Recurrent and Rare Primary Central Nervous System Neoplasms October 26, 2020 February 2025
NCT05084430 Recruiting Phase 1/Phase 2 Study of Pembrolizumab and M032 (NSC 733972) February 25, 2022 March 1, 2028
NCT02800486 Recruiting Phase 2 Super Selective Intra-arterial Repeated Infusion of Cetuximab (Erbitux) With Reirradiation for Treatment of Relapsed/Refractory GBM, AA, and AOA May 2016 May 2026
NCT05956821 Recruiting Phase 1/Phase 2 Treatment of Relapsed/Refractory Intracranial Glioma in Patients Under 22 Years of Age August 1, 2024 December 1, 2029
NCT06108206 Recruiting N/A Adaptive Radiotherapy and MRIs Based on Patients With Newly Diagnosed High-Grade Glioma January 30, 2024 December 31, 2026
NCT05099003 Recruiting Phase 1/Phase 2 A Study of the Drug Selinexor With Radiation Therapy in Patients With Newly-Diagnosed Diffuse Intrinsic Pontine (DIPG) Glioma and High-Grade Glioma (HGG) May 31, 2022 June 30, 2027
NCT02372409 Recruiting Phase 2 Using MRI-Guided Laser Heat Ablation to Induce Disruption of the Peritumoral Blood Brain Barrier to Enhance Delivery and Efficacy of Treatment of Pediatric Brain Tumors August 14, 2015 August 31, 2030
NCT04978727 Recruiting Phase 1 A Pilot Study of SurVaxM in Children Progressive or Relapsed Medulloblastoma, High Grade Glioma, Ependymoma and Newly Diagnosed Diffuse Intrinsic Pontine Glioma July 1, 2022 June 30, 2028
NCT04780009 Recruiting Loupe-Based Intraoperative Fluorescence Imaging November 17, 2017 August 2024
NCT01849952 Recruiting Evaluating the Expression Levels of MicroRNA-10b in Patients With Gliomas February 28, 2020 May 2024
NCT04047264 Recruiting N/A Feasibility of Intraoperative Microdialysis During Neurosurgery for Central Nervous System Malignancies January 1, 2020 September 1, 2027
NCT01386710 Suspended Phase 1/Phase 2 Repeated Super-selective Intraarterial Cerebral Infusion Of Bevacizumab Plus Carboplatin For Treatment Of Relapsed/Refractory GBM And Anaplastic Astrocytoma September 2011 December 2026
NCT03973918 Terminated Phase 2 Study of Binimetinib With Encorafenib in Adults With Recurrent BRAF V600-Mutated HGG July 29, 2019 October 1, 2023
NCT01884740 Terminated Phase 1/Phase 2 Intraarterial Infusion Of Erbitux and Bevacizumab For Relapsed/Refractory Intracranial Glioma In Patients Under 22 June 2013 October 2018
NCT04608812 Terminated Phase 1 Convection-enhanced Delivery of OS2966 for Patients With High-grade Glioma Undergoing a Surgical Resection March 2, 2021 February 27, 2023
NCT02039778 Terminated N/A Stem Cell Radiotherapy and Temozolomide for Newly Diagnosed High-grade Glioma December 2013 December 2015
NCT02168270 Terminated Phase 1 Temozolomide and Ascorbic Acid in Treating Patients With Recurrent High-Grade Glioma June 16, 2014 August 20, 2015
NCT02414165 Terminated Phase 2/Phase 3 The Toca 5 Trial: Toca 511 & Toca FC Versus Standard of Care in Patients With Recurrent High Grade Glioma November 30, 2015 December 20, 2019
NCT00031538 Terminated Genetic Analysis of Brain Tumors March 1, 2002 April 29, 2015
NCT02758366 Terminated Phase 2 Prolonged Exposure to Doxorubicin in Patients With Glioblastoma Multiforme and Diffuse Intrinsic Pontine Glioma February 2016 January 16, 2020
NCT00761280 Terminated Phase 3 Efficacy and Safety of AP 12009 in Patients With Recurrent or Refractory Anaplastic Astrocytoma or Secondary Glioblastoma December 2008 June 2012
NCT02885324 Terminated Phase 2 Pilot Study of Cabozantinib for Recurrent or Progressive Central Nervous System Tumors in Children May 18, 2017 August 25, 2020
NCT01095094 Terminated Phase 2 Ritonavir and Lopinavir in Treating Patients With Progressive or Recurrent High-Grade Glioma January 2009 November 2011
NCT00473408 Terminated The Effect of Radiotherapy and Temozolomide on the Tumor Vasculature and Stem Cells in Human High-grade Astrocytomas March 2007 November 2011
NCT03332355 Terminated Phase 1 Procaspase Activating Compound-1 (PAC-1) in the Treatment of Advanced Malignancies - Component 2 October 1, 2017 December 31, 2021
NCT00062504 Terminated Phase 2 Phase 2 Trial Using Talampanel in Patients With Recurrent High Grade Gliomas July 2003 April 2006
NCT01227434 Terminated Phase 2 A Study of PD 0332991 in Patients With Recurrent Rb Positive Glioblastoma September 2010 December 2013
NCT01281982 Terminated (11C)dLop as a Marker of P-Glycoprotein Function in Patients With Gliomas January 13, 2011 September 24, 2012
NCT03971734 Terminated Phase 1 Determining Dose of Regadenoson Most Likely to Transiently Alter the Integrity of the Blood-Brain Barrier in Patients With High Grade Gliomas December 6, 2019 October 2, 2023
NCT00035373 Terminated Eligibility Screening of Patients With Central Nervous System Tumors for the National Cancer Institute s (NCI) Clinical Research Protocols April 19, 2002 April 29, 2015
NCT01721577 Terminated Phase 1/Phase 2 Phase I/II Trial of AXL1717 in the Treatment of Recurrent Malignant Astrocytomas December 2012 December 2015
NCT01836549 Terminated Phase 2 Imetelstat Sodium in Treating Younger Patients With Recurrent or Refractory Brain Tumors March 2013 April 2016
NCT03370926 Unknown status FET-PET and Multiparametric MRI for High-grade Glioma Patients Undergoing Radiotherapy October 31, 2016 October 31, 2019
NCT02796261 Unknown status Phase 3 Study to Evaluate Eflornithine + Lomustine vs Lomustine in Recurrent Anaplastic Astrocytoma (AA) Patients July 2016 June 2023
NCT01637753 Unknown status N/A Safety and Efficacy Study of Intracranially Implanted Carmustine to Treat Recurrent Malignant Glioma June 2012 December 2013
NCT01656980 Unknown status Phase 3 Safety and Efficacy Study of Intracranially Implanted Carmustine to Treat Newly Diagnosed Malignant Glioma August 2012 December 2014
NCT01765088 Unknown status Phase 3 A Phase III Trial on Adjuvant Temozolomide With or Without Interferon-alpha in Newly Diagnosed High-grade Gliomas September 2012 December 2019
NCT02629757 Unknown status Phase 3 A Study on β-elemene as Maintain Treatment for Newly Diagnosed Malignant Gliomas April 2015 May 2023
NCT00114309 Unknown status Phase 2 131-I-TM-601 Study in Adults With Recurrent High-Grade Glioma November 2004 August 2009
NCT02540135 Withdrawn N/A Fluorescein vs. iMRI in Resection of Malignant High Grade Glioma March 1, 2015 July 18, 2018
NCT04105374 Withdrawn Phase 2/Phase 3 Testing the Addition of an Anti-cancer Viral Gene Therapy, Toca 511/Toca FC, to the Usual Treatment (Temozolomide and Radiation Therapy) for Newly Diagnosed Glioblastoma January 31, 2020 November 30, 2030
NCT00645385 Withdrawn Examination of Changes on Magnetic Resonance Imaging (MRI) and Magnetic Resonance Spectroscopy (MRS) in Patients Who Receive Gliadel Wafers During Initial Surgery for Glioblastoma Multiforme. Response or Failure to Gliadel Wafers for Subjects With Glioblastoma Multiforme. June 2007 June 1, 2011
NCT00734864 Withdrawn Phase 1 Ph. I Dasatinib/Protracted Temozolomide in Recurrent Malignant Glioma June 2009 June 2012
NCT01861990 Withdrawn Phase 1 Valproic Acid in Childhood Progressive Brain Tumors May 2013 December 2013
NCT01711580 Withdrawn Re-irradiation of High Grade Gliomas: a Quality of Life Study March 2013 September 2015
Disase is a (Disease Ontology)
DOID:3069
Cross Reference ID (Disease Ontology)
GARD:5860
Cross Reference ID (Disease Ontology)
MESH:D001254
Cross Reference ID (Disease Ontology)
NCI:C9477
Cross Reference ID (Disease Ontology)
SNOMEDCT_US_2023_03_01:55353007
Cross Reference ID (Disease Ontology)
UMLS_CUI:C0334579
Exact Synonym (Disease Ontology)
grade III Astrocytic tumor
Exact Synonym (Disease Ontology)
grade III astrocytoma
OrphaNumber from OrphaNet (Orphanet)
251589