Hereditary Breast and Ovarian Cancer Syndrome
Information
- Disease name
- Hereditary Breast and Ovarian Cancer Syndrome
- Disease ID
- Description
Disease area statistics
Chromosome band
| Gene symbol | Chromosome | Start | Stop | The number of variant |
|---|---|---|---|---|
| BRCA2 | 13 | 32,315,508 | 32,400,268 | 68 |
| BRCA1 | 17 | 43,044,295 | 43,125,483 | 46 |
| RECQL4 | 8 | 144,511,288 | 144,517,833 | 10 |
| ALK | 2 | 29,192,774 | 29,921,586 | 10 |
| NSD1 | 5 | 177,133,773 | 177,300,213 | 10 |
| TSC2 | 16 | 2,047,985 | 2,089,491 | 10 |
| SDHAF2 | 11 | 61,430,124 | 61,446,733 | 8 |
| RINT1 | 7 | 105,532,201 | 105,567,677 | 8 |
| CHEK2 | 22 | 28,687,763 | 28,741,838 | 6 |
| DICER1 | 14 | 95,086,228 | 95,157,318 | 6 |
Annotation
| Genes | Mutation | Description | Source | Links |
|---|
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT03832985 | Active, not recruiting | Early Phase 1 | Pediatric Reporting of Adult-Onset Genomic Results | November 25, 2020 | June 30, 2024 |
| NCT02760849 | Active, not recruiting | N/A | Surgery in Preventing Ovarian Cancer in Patients With Genetic Mutations | May 2, 2016 | May 31, 2041 |
| NCT00609505 | Completed | N/A | Telemedicine vs. Face-to-Face Cancer Genetic Counseling | August 2008 | April 2011 |
| NCT00892736 | Completed | Phase 1 | Veliparib in Treating Patients With Malignant Solid Tumors That Do Not Respond to Previous Therapy | April 20, 2009 | May 19, 2017 |
| NCT01333748 | Completed | Phase 2 | Search Allelic Imbalance of Expression of BRCA Genes in Hereditary Risk of Breast and/or Ovarian Cancer | April 2010 | June 2012 |
| NCT01367639 | Completed | Phase 2 | Trial of Inquiry Based Stress Reduction (IBSR) Program for BRCA1/2 Mutation Carriers | March 2011 | June 2012 |
| NCT02562170 | Completed | Phase 4 | Protexa® Versus TiLoopBra® in Immediate Breast Reconstruction- A Pilot Study | July 2013 | May 2015 |
| NCT00305695 | Completed | Phase 2 | Zoledronate or Observation in Maintaining Bone Mineral Density in Patients Who Are Undergoing Surgery to Remove Both Ovaries | November 28, 2005 | |
| NCT00535119 | Completed | Phase 1 | Veliparib, Carboplatin, and Paclitaxel in Treating Patients With Advanced Solid Cancer | September 2007 | |
| NCT02956681 | Completed | N/A | Statewide Communication to Reach Diverse Low Income Women | October 2007 | June 2013 |
| NCT03784859 | Completed | Tissue Expansion in Breast Reconstruction Without Drains | February 25, 2019 | October 2, 2020 | |
| NCT04544501 | Completed | N/A | Enhance the Use of Genetic Counseling and Testing in Latinas | February 24, 2020 | January 31, 2022 |
| NCT04197856 | Enrolling by invitation | N/A | Direct Information to At-risk Relatives | February 6, 2020 | December 31, 2025 |
| NCT01445275 | Not yet recruiting | Cost of Cancer Risk Management in Women at Elevated Genetic Risk for Ovarian Cancer Who Participated on GOG-0199 | January 2100 | ||
| NCT05677048 | Recruiting | N/A | Feasibility Study: IGNITE-TX (Identifying Individuals for Genetic Testing & Treatment) Intervention | April 14, 2023 | October 31, 2027 |
| NCT02653105 | Recruiting | N/A | Women at Risk of Breast Cancer and OLFM4 | March 8, 2016 | February 2026 |
| NCT02705924 | Terminated | N/A | Impact of a Psychoeducational Intervention on Expectations and Coping in Young Women Exposed to a High HBOC Risk | April 2016 | September 14, 2021 |
| NCT03294343 | Unknown status | N/A | Risk-Reducing Surgeries for Hereditary Ovarian Cancer | September 1, 2017 | September 1, 2023 |
| NCT03015376 | Unknown status | Inherited Susceptible Genes Among Epithelial Ovarian Cancer | January 2017 | January 2019 | |
| NCT03162276 | Unknown status | Phase 3 | Trial of Inquiry Based Stress Reduction (IBSR) Program for BRCA1/2 Mutation Carriers | July 1, 2017 | December 30, 2020 |
- OrphaNumber from OrphaNet (Orphanet)
- 145
- MeSH unique ID (MeSH (Medical Subject Headings))
- D061325