chr20:46008908:> Detail (hg38)

Information

Genome

Assembly Position
hg19 chr20:44,637,547-44,645,200 
hg38 chr20:46,008,908-46,016,561

HGVS

Type Transcript Protein
Summary

MGeND

Clinical significance
Variant entry
GWAS entry
Disease area statistics Show details

Frequency

[No Data.]

Prediction

[No Data.]

ClinVar

Clinical Significance
Review star [No Data.]
Show details
Links
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
[No Data.]
CIViC
[No Data.]
DisGeNET
Score Disease name Description Source Pubmed Links
0.163 squamous cell carcinoma NA BeFree,CTD_human,GAD,LHGDN Detail
<0.001 Carcinoma, Transitional Cell NA BeFree Detail
0.005 Cardiomyopathy, Dilated NA BeFree,GAD,LHGDN Detail
0.010 Cardiovascular Diseases A remarkable finding in the present study is the previously unrecognized associa... BeFree,GAD,LHGDN 25055059 Detail
0.010 Cardiovascular Diseases In this study, the possible association between MMP-9 and MMP-2 functional promo... BeFree,GAD,LHGDN 25416694 Detail
0.008 Carotid Artery Diseases NA GAD,LHGDN Detail
0.008 carotid stenosis NA GAD,LHGDN Detail
0.120 Neoplastic Cell Transformation NA CTD_human Detail
0.081 intracranial aneurysm NA BeFree,RGD Detail
0.002 cerebral infarction NA BeFree Detail
0.208 brain ischemia NA CTD_human,GAD,LHGDN,RGD Detail
0.080 Transient ischemic attack NA RGD Detail
0.002 Malignant tumor of cervix NA BeFree Detail
0.003 Uterine Cervical Neoplasm NA LHGDN Detail
<0.001 cholelithiasis NA BeFree Detail
<0.001 chondrosarcoma NA BeFree Detail
0.002 chorioamnionitis NA GAD Detail
<0.001 choriocarcinoma NA BeFree Detail
<0.001 Bronchitis, Chronic NA BeFree Detail
<0.001 Churg-Strauss syndrome NA BeFree Detail
0.005 cleft lip NA GAD,LHGDN Detail
0.002 cleft palate NA GAD Detail
0.080 Cognition Disorders NA RGD Detail
0.002 colitis Butein ameliorated colitis in IL-10(-/-) mice by regulating IL-6/STAT3 and MMP-9... BeFree 25593461 Detail
0.121 ulcerative colitis NA BeFree,CTD_human Detail
0.208 Colonic Neoplasms NA BeFree,CTD_human,LHGDN,RGD Detail
0.009 colorectal carcinoma Interestingly, Nur77-mediated CRC invasion via MMP-9 and E-cadherin could be mim... BeFree 25064356 Detail
0.009 colorectal carcinoma At last, in the tumor samples from patients with locally advanced colorectal can... BeFree 25205654 Detail
0.009 colorectal carcinoma Our results suggest that DIM can influence the cell migratory and invasive prope... BeFree 25962429 Detail
0.122 Colorectal Neoplasms NA BeFree,GAD,LHGDN,RGD Detail
0.002 Connective Tissue Diseases NA GAD Detail
0.005 Febrile Convulsions NA GAD,LHGDN Detail
0.003 corneal ulcer NA LHGDN Detail
0.003 coronary aneurysm NA LHGDN Detail
0.020 Coronary Arteriosclerosis The MMP-9 -1562 C/T polymorphism in the presence of metabolic syndrome increases... BeFree,GAD 25191702 Detail
0.020 Coronary heart disease The MMP-9 -1562 C/T polymorphism in the presence of metabolic syndrome increases... BeFree,GAD,LHGDN 25191702 Detail
<0.001 coronary thrombosis NA BeFree Detail
<0.001 craniosynostosis The expression of PRRs (Toll-like receptors and melanoma differentiation-associa... BeFree 26047816 Detail
0.002 Crohn Disease NA GAD Detail
<0.001 Infection by Cryptococcus neoformans NA BeFree Detail
0.001 cutis laxa NA BeFree Detail
0.003 adenoid cystic carcinoma NA BeFree,LHGDN Detail
0.003 cystic fibrosis NA BeFree,LHGDN Detail
<0.001 Cyst NA BeFree Detail
<0.001 Dementia, Vascular Genes that were upregulated in VaD were MMP9 and VEGFA. BeFree 25024308 Detail
0.003 dermatitis NA BeFree,LHGDN Detail
0.003 dermatomyositis NA BeFree,LHGDN Detail
0.002 Diabetes One of the important genes involved in extracellular matrix (ECM) remodeling in ... BeFree 25064116 Detail
0.003 diabetes mellitus One of the important genes involved in extracellular matrix (ECM) remodeling in ... BeFree 25064116 Detail
0.200 Diabetes Mellitus, Experimental NA CTD_human,RGD Detail
<0.001 Diabetes Mellitus, Insulin-Dependent NA BeFree Detail
0.094 Diabetes Mellitus, Non-Insulin-Dependent NA BeFree,GAD,RGD Detail
0.002 Diabetic Angiopathies NA GAD Detail
0.005 Diabetic Nephropathy Matrix metalloproteinase-9 deficiency attenuates diabetic nephropathy by modulat... BeFree,LHGDN 24670409 Detail
0.005 Diabetic Nephropathy Coincident with these changes in receptor expression but not activity, MMP-9 was... BeFree,LHGDN 25549045 Detail
0.120 Diabetic Neuropathies NA CTD_human Detail
0.003 diabetic retinopathy NA BeFree,GAD Detail
0.003 Pathological Dilatation NA LHGDN Detail
<0.001 Dissecting aortic aneurysm NA BeFree Detail
0.001 Dry Eye Syndromes Matrix metalloproteinase 9 and transglutaminase 2 expression at the ocular surfa... BeFree 25240629 Detail
0.001 Dry Eye Syndromes In our experiments, elevated expression of MMP9 in dry eye subjects correlated w... BeFree 25703476 Detail
<0.001 Muscular Dystrophy, Duchenne NA BeFree Detail
0.002 duodenal ulcer NA GAD Detail
<0.001 eclampsia NA BeFree Detail
0.005 Edema NA LHGDN Detail
0.005 Pathological accumulation of air in tissues NA GAD Detail
0.080 Experimental Autoimmune Encephalomyelitis NA BeFree,RGD Detail
<0.001 endocarditis NA BeFree Detail
0.008 Endometrial Neoplasms NA LHGDN Detail
0.104 endometriosis NA BeFree,GAD,LHGDN,RGD Detail
0.080 Epilepsies, Partial NA RGD Detail
0.080 absence epilepsy NA RGD Detail
0.003 Epilepsy, Temporal Lobe NA BeFree,GAD Detail
<0.001 Erythema Chronicum Migrans NA BeFree Detail
0.006 Esophageal Neoplasms We found that the levels of PLGF in TE-1 cells positively affected the levels of... BeFree,GAD,LHGDN 25213700 Detail
<0.001 Exanthema NA BeFree Detail
<0.001 Fanconi anemia IL-6, IL-8, MMP-2, MMP-9 are overexpressed in Fanconi anemia cells through a NF-... BeFree 25358651 Detail
0.002 Fetal Diseases NA GAD Detail
0.003 Fetal Growth Retardation NA LHGDN Detail
0.005 Fetal Membranes, Premature Rupture NA GAD Detail
<0.001 breast fibrocystic disease NA BeFree Detail
0.010 fibrosarcoma Galangin and kaempferol suppress phorbol-12-myristate-13-acetate-induced matrix ... BeFree,LHGDN 25518925 Detail
0.082 Fibrosis NA GAD,RGD Detail
<0.001 pathologic fistula NA BeFree Detail
<0.001 fragile X syndrome Pharmacogenetic inhibition of eIF4E-dependent Mmp9 mRNA translation reverses fra... BeFree 25466251 Detail
<0.001 gastritis NA BeFree Detail
<0.001 Giant Cell Tumors NA BeFree Detail
0.003 gingivitis NA BeFree,GAD Detail
0.008 Angle Closure Glaucoma NA BeFree,GAD,LHGDN Detail
0.001 primary angle-closure glaucoma NA BeFree Detail
0.137 glioblastoma A significant decline of MMP-9 and MMP-2 secretion in cultured U87MG was detecte... BeFree,CTD_human,LHGDN 25256634 Detail
0.020 Glioma TWEAK also promotes noncanonical NFκB-dependent MMP9 expression and glioma cell ... BeFree,LHGDN 25622756 Detail
0.020 Glioma Meanwhile, mangiferin specifically promoted the expression of miR-15b and suppre... BeFree,LHGDN 25901555 Detail
0.003 glomerulonephritis NA BeFree,LHGDN Detail
0.123 IgA glomerulonephritis NA BeFree,CTD_human,LHGDN Detail
0.080 membranous glomerulonephritis NA RGD Detail
0.080 Focal glomerulosclerosis NA RGD Detail
<0.001 Glossitis, Benign Migratory NA BeFree Detail
0.002 Graft Occlusion, Vascular NA GAD Detail
0.003 Granuloma NA LHGDN Detail
0.002 Guillain-Barre syndrome NA GAD Detail
<0.001 Hay fever NA BeFree Detail
0.003 Heart Diseases NA BeFree,GAD Detail
0.080 Cardiomegaly NA RGD Detail
0.084 Heart failure In this review, we discuss mitochondrial dynamics, its relation to MMP-9 and Cx-... BeFree,LHGDN,RGD 24905188 Detail
0.084 Heart failure Activated Mmp9 degrades extracellular matrix (ECM) and increases matrix turnover... BeFree,LHGDN,RGD 25064116 Detail
0.001 congestive heart failure In this review, we discuss mitochondrial dynamics, its relation to MMP-9 and Cx-... BeFree 24905188 Detail
0.001 congestive heart failure Activated Mmp9 degrades extracellular matrix (ECM) and increases matrix turnover... BeFree 25064116 Detail
<0.001 Hemangiosarcoma NA BeFree Detail
0.003 Hemorrhage NA LHGDN Detail
<0.001 hepatitis A NA BeFree Detail
0.003 hepatitis B It was concluded that patients with the MMP-9 TT genotype are at risk of develop... BeFree,GAD 25299117 Detail
<0.001 Hepatitis, Chronic NA BeFree Detail
0.003 hepatitis C The association between MMP-9 gene polymorphisms and HCC patients with hepatitis... BeFree,GAD 25299117 Detail
<0.001 Herpes Simplex Infections NA BeFree Detail
0.002 HIV Infections NA BeFree Detail
0.003 Hodgkin Disease NA BeFree,LHGDN Detail
<0.001 HTLV-I Infections NA BeFree Detail
<0.001 Huntington disease NA BeFree Detail
0.003 Hypercholesterolemia, Familial NA BeFree,LHGDN Detail
0.080 hyperglycemia NA BeFree,RGD Detail
0.123 Hyperplasia NA CTD_human,LHGDN Detail
0.101 Hypertensive disease MMP-9 (C/T + T/T) genotype increased risk of hypertension in SLE patients 2.71-f... BeFree,GAD,LHGDN,RGD 25416694 Detail
0.080 pulmonary hypertension NA RGD Detail
0.080 renal hypertension NA RGD Detail
0.140 Inflammation NA CTD_human,GAD,LHGDN Detail
0.004 Inflammatory Bowel Diseases NA BeFree,LHGDN Detail
<0.001 influenza NA BeFree Detail
0.005 Intervertebral Disk Displacement NA GAD Detail
0.004 ischemia NA BeFree,LHGDN Detail
<0.001 arthropathy NA BeFree Detail
<0.001 Keloid NA BeFree Detail
<0.001 keratoacanthoma NA BeFree Detail
<0.001 keratoconjunctivitis sicca NA BeFree Detail
<0.001 keratoconus Collagen transcripts were also reduced in KC while MMP9 transcript levels were u... BeFree 25593510 Detail
<0.001 keratoconus Elevated expression of matrix metalloproteinase-9 and inflammatory cytokines in ... BeFree 25648341 Detail
0.087 Kidney Diseases However, MMP-9 knockout in diabetic mice significantly attenuated these nephropa... BeFree,GAD,LHGDN,RGD 24670409 Detail
0.006 Kidney Failure, Chronic NA BeFree,GAD Detail
<0.001 Kidney Neoplasm NA BeFree Detail
0.002 Premature Obstetric Labor NA GAD Detail
0.120 Lead Poisoning NA CTD_human Detail
<0.001 Fibroid Tumor NA BeFree Detail
0.005 leukemia NFκB- and AP-1-mediated DNA looping regulates matrix metalloproteinase-9 transcr... BeFree,LHGDN 26260845 Detail
0.011 chronic lymphocytic leukemia Matrix metalloproteinase-9 is involved in chronic lymphocytic leukemia cell resp... BeFree,GAD,LHGDN 24956101 Detail
0.005 Leukemia, Myelocytic, Acute Secreted matrix metalloproteinases (MMP)-2 and MMP-9 and membrane-anchored amino... BeFree,LHGDN 25246708 Detail
0.005 Leukemia, Myelocytic, Acute We recently found that the tetraspanin family member, CD82, which is aberrantly ... BeFree,LHGDN 25955299 Detail
0.001 Myeloid Leukemia, Chronic NA BeFree Detail
<0.001 Leukemia, T-Cell The spread and metastases of ATL as well as other tumors has been associated wit... BeFree 25189759 Detail
0.003 Adult T-Cell Lymphoma/Leukemia The spread and metastases of ATL as well as other tumors has been associated wit... BeFree,LHGDN 25189759 Detail
0.003 Leukocytosis NA LHGDN Detail
0.003 lichen planus NA LHGDN Detail
<0.001 Lichen Sclerosus et Atrophicus NA BeFree Detail
<0.001 Lipoid Proteinosis of Urbach and Wiethe NA BeFree Detail
0.006 liver cirrhosis NA BeFree,GAD Detail
0.080 Biliary cirrhosis NA RGD Detail
0.120 Liver Cirrhosis, Experimental NA CTD_human Detail
0.127 Liver diseases NA BeFree,CTD_human,LHGDN Detail
0.080 Alcoholic Liver Diseases NA RGD Detail
0.008 Liver neoplasms Moreover, NS3 enhanced hepatoma cell invasion and migration through MMP-9 and CO... BeFree,GAD 25305454 Detail
0.080 Liver Neoplasms, Experimental NA RGD Detail
0.002 long QT syndrome NA GAD Detail
0.089 Lung diseases NA BeFree,LHGDN,RGD Detail
0.166 Chronic Obstructive Airway Disease Relationship between expression of matrix metalloproteinase-9 and adenylyl cycla... BeFree,CTD_human,GAD,LHGDN 25332229 Detail
0.028 Lung Neoplasms Importantly, we demonstrate the feasibility of MMP9-controlled drug release in h... BeFree,GAD,LHGDN 25703655 Detail
<0.001 Lupus Vulgaris In this study, the possible association between MMP-9 and MMP-2 functional promo... BeFree 25416694 Detail
<0.001 Lupus Erythematosus, Discoid In this study, the possible association between MMP-9 and MMP-2 functional promo... BeFree 25416694 Detail
0.012 Lupus Erythematosus, Systemic Matrix metalloproteinase 9 polymorphisms and systemic lupus erythematosus: corre... BeFree,GAD,LHGDN 25416694 Detail
0.120 lupus nephritis NA CTD_human Detail
0.003 Lyme disease NA BeFree,LHGDN Detail
0.004 Lymphatic Metastasis NA BeFree,GAD Detail
0.005 lymphoma NA BeFree,LHGDN Detail
<0.001 Lymphoma, Follicular NA BeFree Detail
0.003 Lymphoma, Non-Hodgkin NA BeFree,GAD Detail
<0.001 Mycetoma NA BeFree Detail
<0.001 malaria Matrix metalloproteinase-9 polymorphism 1562 C > T (rs3918242) associated with p... BeFree 26013370 Detail
<0.001 Malaria, Falciparum NA BeFree Detail
0.016 Malignant neoplasm of stomach CXCR1, CXCR2, and MMP9 were expressed in 61.0%, 77.9%, and 75.6% of gastric canc... BeFree,GAD 25022956 Detail
0.016 Malignant neoplasm of stomach Calcium/calmodulin‑dependent protein kinase II enhances metastasis of human gast... BeFree,GAD 25174603 Detail
0.016 Malignant neoplasm of stomach Moreover, ALDH1A1 was significantly correlated with MMP-9 among 216 gastric canc... BeFree,GAD 25253129 Detail
0.016 Malignant neoplasm of stomach The AKT/AR/MMP9 pathway plays an important role in GC metastasis and may be a no... BeFree,GAD 25301736 Detail
0.016 Malignant neoplasm of stomach Knockdown of EGFR reduced cell proliferation and invasion of GC with decreased e... BeFree,GAD 25394504 Detail
0.016 Malignant neoplasm of stomach Additionally, CEACAM6 elevated matrix metalloproteinase-9 (MMP-9) activity in GC... BeFree,GAD 25398131 Detail
0.016 Malignant neoplasm of stomach Fz2 shRNA suppressed cell proliferation and motility of MKN45 and MKN74 cells, a... BeFree,GAD 25586465 Detail
0.016 Malignant neoplasm of stomach The HER-2 positive SGC-7901 secreted more transforming growth factor beta 1 (TGF... BeFree,GAD 25613482 Detail
0.016 Malignant neoplasm of stomach Overexpression of SMYD3 and matrix metalloproteinase-9 are associated with poor ... BeFree,GAD 25627005 Detail
0.016 Malignant neoplasm of stomach MMP-9 is increased in the pathogenesis of gastric cancer by the mediation of HER... BeFree,GAD 25633484 Detail
0.016 Malignant neoplasm of stomach Activation of matrix metalloproteinase-9 (MMP-9) by neurotensin promotes cell in... BeFree,GAD 25724188 Detail
0.016 Malignant neoplasm of stomach WISP-2 suppressed GC cell metastasis through reversing EMT and suppressing the e... BeFree,GAD 26291058 Detail
0.200 Mammary Neoplasms, Experimental NA CTD_human,RGD Detail
0.120 Marfan syndrome NA CTD_human Detail
0.001 medulloblastoma NA BeFree Detail
0.017 melanoma The expression of PRRs (Toll-like receptors and melanoma differentiation-associa... BeFree,GAD,LHGDN 26047816 Detail
<0.001 multiple endocrine neoplasia type 1 NA BeFree Detail
0.007 meningioma Deficiency of the protein-tyrosine phosphatase DEP-1/PTPRJ promotes matrix metal... BeFree,LHGDN 25672645 Detail
<0.001 meningitis NA BeFree Detail
0.080 meningococcal meningitis NA BeFree,RGD Detail
0.083 Meningitis, Pneumococcal NA LHGDN,RGD Detail
0.003 viral meningitis NA BeFree,LHGDN Detail
0.003 Mesothelioma NA BeFree,LHGDN Detail
0.005 Metaplasia NA GAD,LHGDN Detail
<0.001 mitral valve stenosis NA BeFree Detail
<0.001 Mixed Salivary Gland Tumor NA BeFree Detail
0.120 morphine dependence NA CTD_human Detail
0.008 Mouth Neoplasms NA GAD,LHGDN Detail
0.002 Moyamoya disease NA GAD Detail
0.006 Mucocutaneous Lymph Node Syndrome NA BeFree,GAD,LHGDN Detail
<0.001 multiple myeloma NA BeFree Detail
0.200 Multiple Organ Failure NA CTD_human,RGD Detail
0.029 multiple sclerosis MMP-9 expression is increased in B lymphocytes during multiple sclerosis exacerb... BeFree,GAD,LHGDN 25468268 Detail
0.029 multiple sclerosis We could not detect an association of MMP9 SNPs with MS on a genome-wide signifi... BeFree,GAD,LHGDN 25670000 Detail
0.029 multiple sclerosis Previous studies show altered activities of matrix metalloproteinase (MMP)-2 and... BeFree,GAD,LHGDN 26298319 Detail
<0.001 myopathy NA BeFree Detail
<0.001 muscular dystrophy NA BeFree Detail
0.002 Musculoskeletal Diseases NA GAD Detail
0.003 Mycobacterium Infections NA LHGDN Detail
0.080 Mycoplasma Infections NA RGD Detail
<0.001 mycosis fungoides NA BeFree Detail
<0.001 Myelodysplasia NA BeFree Detail
<0.001 Myeloproliferative disease MMP2 gene-735 C/T and MMP9 gene -1562 C/T polymorphisms in JAK2V617F positive my... BeFree 25684469 Detail
0.225 myocardial infarction Serum MMP-9 and CRP levels were significantly higher in the ACS group compared w... BeFree,CTD_human,GAD,LHGDN,RGD 24709882 Detail
0.225 myocardial infarction Overexpression of MMP-9 and its inhibitors in blood mononuclear cells after myoc... BeFree,CTD_human,GAD,LHGDN,RGD 25153995 Detail
0.003 myocarditis NA BeFree,LHGDN Detail
<0.001 myoepithelioma NA BeFree Detail
<0.001 myopia NA BeFree Detail
0.003 myositis NA LHGDN Detail
0.006 Nasal Polyps NA BeFree,GAD,LHGDN Detail
0.123 Neoplasm Invasiveness NA CTD_human,LHGDN Detail
0.315 Neoplasm Metastasis TNCL increased the expression of several oncogenes, including MMP9, anaplastic l... BeFree,CTD_human,LHGDN,RGD 24632608 Detail
0.315 Neoplasm Metastasis Matrix metalloproteinase-9 (MMP-9) plays an important role in the invasion and m... BeFree,CTD_human,LHGDN,RGD 25000305 Detail
0.315 Neoplasm Metastasis Orphan nuclear receptor Nur77 promotes colorectal cancer invasion and metastasis... BeFree,CTD_human,LHGDN,RGD 25064356 Detail
0.315 Neoplasm Metastasis SEMA4b inhibits MMP9 to prevent metastasis of non-small cell lung cancer. BeFree,CTD_human,LHGDN,RGD 25095981 Detail
0.315 Neoplasm Metastasis Lastly, the clinical relevance of MMP-9 overexpression is strongly supported by ... BeFree,CTD_human,LHGDN,RGD 25151367 Detail
0.315 Neoplasm Metastasis The spread and metastases of ATL as well as other tumors has been associated wit... BeFree,CTD_human,LHGDN,RGD 25189759 Detail
0.315 Neoplasm Metastasis In the current study, we detected significant higher levels of placental growth ... BeFree,CTD_human,LHGDN,RGD 25213700 Detail
0.315 Neoplasm Metastasis Matrix metalloproteinase-9 (MMP-9) plays a key role in cancer invasion and metas... BeFree,CTD_human,LHGDN,RGD 25299117 Detail
0.315 Neoplasm Metastasis As matrix metalloproteinase-9 (MMP-9) plays a critical role in tumor metastasis,... BeFree,CTD_human,LHGDN,RGD 25310109 Detail
0.315 Neoplasm Metastasis MMP-9-delivering TANs were also required for development of metastasis-supportin... BeFree,CTD_human,LHGDN,RGD 25379015 Detail
0.315 Neoplasm Metastasis Moreover, HOTAIR regulated the expression of vascular endothelial growth factor,... BeFree,CTD_human,LHGDN,RGD 25405331 Detail
0.315 Neoplasm Metastasis Moreover, patients that had NSCLC with metastasis had significantly higher level... BeFree,CTD_human,LHGDN,RGD 25424698 Detail
0.315 Neoplasm Metastasis We found that PLGF and MMP9 levels strongly correlated in OSCC in the patients, ... BeFree,CTD_human,LHGDN,RGD 25432135 Detail
0.315 Neoplasm Metastasis Our experimental results suggest that HCS has some anti-metastasis potential to ... BeFree,CTD_human,LHGDN,RGD 25496480 Detail
0.315 Neoplasm Metastasis Taken together, our findings suggest that radixin is involved in GBM cell migrat... BeFree,CTD_human,LHGDN,RGD 25520109 Detail
0.315 Neoplasm Metastasis Neutrophil gelatinase-associated lipocalin (NGAL) and matrix metalloproteinase-9... BeFree,CTD_human,LHGDN,RGD 25542236 Detail
0.315 Neoplasm Metastasis However, the exact roles of SMYD3 and MMP-9 in the metastasis and prognosis of g... BeFree,CTD_human,LHGDN,RGD 25627005 Detail
0.315 Neoplasm Metastasis GOLPH3 overexpression is closely correlated with poor prognosis in human non-sma... BeFree,CTD_human,LHGDN,RGD 25659977 Detail
0.315 Neoplasm Metastasis Matrix metalloproteinase-9 (MMP-9) plays a central role in the invasion and meta... BeFree,CTD_human,LHGDN,RGD 25670016 Detail
0.315 Neoplasm Metastasis MiR-129 regulates MMP9 to control metastasis of non-small cell lung cancer. BeFree,CTD_human,LHGDN,RGD 25716201 Detail
0.315 Neoplasm Metastasis Our findings suggested that HEY1 augmented the metastasis of osteosarcoma via up... BeFree,CTD_human,LHGDN,RGD 25742474 Detail
0.315 Neoplasm Metastasis Testes-specific protease 50 promotes cell invasion and metastasis by increasing ... BeFree,CTD_human,LHGDN,RGD 25811800 Detail
0.315 Neoplasm Metastasis The results suggested that CMCS could significantly inhibit tumor cell migration... BeFree,CTD_human,LHGDN,RGD 25857959 Detail
0.315 Neoplasm Metastasis The present study demonstrated that GRP78 plays important roles in invasion and ... BeFree,CTD_human,LHGDN,RGD 25976624 Detail
0.315 Neoplasm Metastasis BAG3 (p=0.013), TAP1 (p=0.014), BNIP3 (p<0.001) and MMP9 (p=0.036) were overexpr... BeFree,CTD_human,LHGDN,RGD 26232338 Detail
0.315 Neoplasm Metastasis WISP-2 suppressed GC cell metastasis through reversing EMT and suppressing the e... BeFree,CTD_human,LHGDN,RGD 26291058 Detail
<0.001 gallbladder carcinoma Multidimensional reduction analysis revealed LXR-β (rs3546355 G &gt; A, rs269512... BeFree 24863943 Detail
<0.001 Malignant neoplasm of gallbladder Multidimensional reduction analysis revealed LXR-β (rs3546355 G &gt; A, rs269512... BeFree 24863943 Detail
0.080 Neuritis, Autoimmune, Experimental NA RGD Detail
0.003 neuroblastoma Gain- and loss-of-function studies indicated that secretory ITLN1 facilitated th... BeFree 25889839 Detail
0.003 Neuromuscular Diseases NA LHGDN Detail
<0.001 neuromyelitis optica Previous studies show altered activities of matrix metalloproteinase (MMP)-2 and... BeFree 26298319 Detail
0.123 obesity NA BeFree,CTD_human Detail
0.080 ocular hypertension NA RGD Detail
<0.001 Opportunistic Infections NA BeFree Detail
<0.001 optic neuritis Here we investigated the impacts of MMP-2 -1575G/A and MMP-9 -1562 C/T gene poly... BeFree 26298319 Detail
0.121 oral submucous fibrosis NA BeFree,CTD_human Detail
0.002 Degenerative polyarthritis NA BeFree Detail
<0.001 Osteoarthritis of hip Comparing to OA, aseptic loosening of TKA is associated with upregulated express... BeFree 25151085 Detail
<0.001 Cartilaginous exostosis Then we demonstrated that SPON1 was significantly up-regulated in 72 osteosarcom... BeFree 26032498 Detail
0.009 osteosarcoma Knockdown of GAL1 suppressed cell proliferative activities and invasive potentia... BeFree,LHGDN 25069486 Detail
0.009 osteosarcoma Overexpression of RASSF5 markedly suppressed cell proliferation and invasion, an... BeFree,LHGDN 25109282 Detail
0.009 osteosarcoma We then examined the effect of HN.49 on the enzyme activity of MMP9 and the migr... BeFree,LHGDN 25177029 Detail
0.009 osteosarcoma Thus, miR-143, EGFR, and MMP9 are therapeutic targets for inhibiting OS invasion... BeFree,LHGDN 25227664 Detail
0.009 osteosarcoma ERK5 silencing inhibits invasion of human osteosarcoma cell via modulating the S... BeFree,LHGDN 25317798 Detail
0.009 osteosarcoma Our findings suggested that HEY1 augmented the metastasis of osteosarcoma via up... BeFree,LHGDN 25742474 Detail
0.003 Otitis Media with Effusion NA LHGDN Detail
0.007 ovarian carcinoma The results demonstrated that siRNA-mediated knockdown of MMP-9 in the human ova... BeFree 25738807 Detail
<0.001 Ovarian Cysts NA BeFree Detail
<0.001 Pain NA BeFree Detail
0.134 Pancreatic Neoplasm NA BeFree,CTD_human,LHGDN Detail
<0.001 tropical spastic paraparesis NA BeFree Detail
0.003 parotitis NA LHGDN Detail
<0.001 bullous pemphigoid NA BeFree Detail
0.003 pemphigus NA LHGDN Detail
<0.001 pemphigus vulgaris NA BeFree Detail
0.131 periodontitis NA BeFree,CTD_human,GAD Detail
<0.001 Periodontitis, Juvenile NA BeFree Detail
0.003 Peripheral neuropathy NA LHGDN Detail
0.002 pituitary adenoma The interactions of NF-κB, MMP-9, and MICA play an important role in the develop... BeFree 25921632 Detail
0.003 Pituitary Neoplasms NA BeFree,LHGDN Detail
0.003 Pleural effusion disorder NA BeFree,LHGDN Detail
0.004 pneumonia NA BeFree,LHGDN Detail
0.003 polycystic ovary syndrome NA LHGDN Detail
<0.001 polycythemia vera Consequently this study supported that CC genotype of MMP9 gene -1562 C/T polymo... BeFree 25684469 Detail
<0.001 Adenomatous Polyposis Coli NA BeFree Detail
0.003 polyps NA BeFree,LHGDN Detail
0.013 pre-eclampsia NA GAD,LHGDN Detail
<0.001 Precancerous Conditions NA BeFree Detail
0.002 Pregnancy Complications, Hematologic NA GAD Detail
<0.001 Preleukemia NA BeFree Detail
<0.001 prolactinoma Matrix metalloproteinase-9 and tissue inhibitor of matrix metalloproteinase-2: P... BeFree 26071077 Detail
<0.001 ptosis NA BeFree Detail
0.143 Prostatic Neoplasms NA BeFree,CTD_human,LHGDN Detail
<0.001 pseudoxanthoma elasticum NA BeFree Detail
<0.001 psoriasis NA BeFree Detail
<0.001 Psychotic Disorders NA BeFree Detail
<0.001 pterygium NA BeFree Detail
0.080 pulmonary embolism NA RGD Detail
0.086 pulmonary emphysema NA BeFree,LHGDN,RGD Detail
0.201 pulmonary fibrosis NA BeFree,CTD_human,RGD Detail
0.003 purpura NA LHGDN Detail
0.003 pyelonephritis NA LHGDN Detail
<0.001 Refractive Errors NA BeFree Detail
<0.001 kidney failure NA BeFree Detail
0.203 Reperfusion Injury NA CTD_human,LHGDN,RGD Detail
<0.001 Respiratory Distress Syndrome, Newborn NA BeFree Detail
<0.001 Respiratory Distress Syndrome, Adult NA BeFree Detail
<0.001 Respiratory Syncytial Virus Infections NA BeFree Detail
0.120 Retinal Diseases NA BeFree,CTD_human Detail
<0.001 retinoblastoma In addition, a reverse correlation between miR-204 and CyclinD2 or MMP-9 express... BeFree 25647033 Detail
<0.001 rhabdomyosarcoma NA BeFree Detail
0.004 schizophrenia NA BeFree,GAD Detail
0.008 systemic scleroderma NA BeFree,GAD,LHGDN Detail
<0.001 Seizures NA BeFree Detail
<0.001 Septicemia NA BeFree Detail
0.002 sinusitis NA GAD Detail
0.003 Dermatologic disorders NA BeFree,GAD Detail
0.125 Skin Neoplasms NA CTD_human,GAD,LHGDN Detail
0.003 Spinal Cord Diseases NA LHGDN Detail
0.002 Spinal Diseases NA GAD Detail
0.080 status epilepticus NA RGD Detail
0.003 Stevens-Johnson syndrome NA LHGDN Detail
0.099 Stomach Neoplasms NA GAD,LHGDN,RGD Detail
0.203 gastric ulcer NA BeFree,CTD_human,GAD,RGD Detail
<0.001 Stricture of artery NA BeFree Detail
0.089 Cerebrovascular accident Association between the MMP-9-1562 C>T polymorphism and the risk of stroke: a me... BeFree,GAD,RGD 25012915 Detail
0.089 Cerebrovascular accident Matrix metalloproteinase-9 (MMP-9, Gelantinase B) has been shown to relate to st... BeFree,GAD,RGD 25932641 Detail
0.003 subacute sclerosing panencephalitis NA LHGDN Detail
0.080 Subarachnoid Hemorrhage NA BeFree,RGD Detail
<0.001 substance dependence NA BeFree Detail
0.120 Substance Withdrawal Syndrome NA CTD_human Detail
<0.001 synovial sarcoma NA BeFree Detail
0.003 pigmented villonodular synovitis NA BeFree,LHGDN Detail
0.003 Takayasu Arteritis NA LHGDN Detail
0.009 Giant Cell Arteritis NA BeFree,GAD,LHGDN Detail
<0.001 Temporomandibular Joint Disorders Association of Functional Polymorphisms in Matrix Metalloproteinase-9 and Glutat... BeFree 26244436 Detail
<0.001 Temporomandibular Joint Dysfunction Syndrome A statistically significant difference in genotype and allele frequencies was fo... BeFree 26244436 Detail
<0.001 tetralogy of Fallot NA BeFree Detail
<0.001 Thrombocythemia, Essential To our knowledge, this is the first investigation of associations between the -7... BeFree 25684469 Detail
0.002 thrombosis NA GAD Detail
0.003 Thyroid Neoplasm The rates of positive immunostaining for COX-2, MMP-9 and VEGF in PTC tumours we... BeFree,LHGDN 24670538 Detail
<0.001 Chagas disease NA BeFree Detail
0.004 tuberculosis NA BeFree,LHGDN Detail
<0.001 Tuberculosis, Meningeal NA BeFree Detail
0.005 Tuberculosis, Pulmonary NA BeFree,GAD Detail
0.003 Ulcer NA LHGDN Detail
0.002 Uterine Diseases NA GAD Detail
<0.001 Uterine Fibroids NA BeFree Detail
0.003 Uterine hemorrhage NA LHGDN Detail
0.004 Varicosity NA BeFree,LHGDN Detail
<0.001 Vascular Diseases NA BeFree Detail
<0.001 vasculitis NA BeFree Detail
0.080 Venous Thrombosis NA RGD Detail
<0.001 viral hepatitis The association between MMP-9 gene polymorphisms and HCC patients with hepatitis... BeFree 25299117 Detail
<0.001 Virus Diseases NA BeFree Detail
<0.001 Wheezing NA BeFree Detail
<0.001 epidermolysis bullosa simplex NA BeFree Detail
<0.001 Hallopeau-Siemens Disease NA BeFree Detail
0.005 Helicobacter Infections NA GAD Detail
<0.001 Ichthyosis, X-Linked NA BeFree Detail
<0.001 B-Cell Lymphomas Furthermore, exogenous miR-1224-5p expression was shown to down-regulate CREB1, ... BeFree 25648114 Detail
<0.001 B-Cell Lymphomas The results also demonstrated that downregulation of MMP-9 led to cell apoptosis... BeFree 25738807 Detail
<0.001 Lymphoma, Large-Cell, Follicular NA BeFree Detail
0.003 Pleural Effusion, Malignant NA BeFree,LHGDN Detail
0.003 Peripheral Vascular Diseases NA BeFree,GAD Detail
<0.001 severe combined immunodeficiency NA BeFree Detail
0.002 bacterial vaginosis NA GAD Detail
0.003 Meningitis, Bacterial NA BeFree,LHGDN Detail
<0.001 essential hypertension NA BeFree Detail
0.003 polymyositis NA BeFree,LHGDN Detail
<0.001 Alcohol abuse NA BeFree Detail
<0.001 Depressive Symptoms Our findings indicate that overexpression of MMP-9 and TIMPs in blood mononuclea... BeFree 25153995 Detail
<0.001 benign neoplasm NA BeFree Detail
0.001 Chronic sinusitis NA BeFree Detail
<0.001 Bicuspid aortic valve NA BeFree Detail
<0.001 Epstein-Barr Virus Infections NA BeFree Detail
0.006 Left Ventricular Hypertrophy NA BeFree,GAD Detail
<0.001 Deep Vein Thrombosis NA BeFree Detail
<0.001 Small cell carcinoma of lung NA BeFree Detail
<0.001 obstructive nephropathy NA BeFree Detail
0.129 Premature Birth NA CTD_human,GAD Detail
<0.001 Oral Cavity Carcinoma NA BeFree Detail
0.002 Intracranial Hemorrhages NA GAD Detail
0.008 Myocardial Ischemia NA BeFree,GAD,LHGDN Detail
<0.001 Cutaneous Melanoma NA BeFree Detail
<0.001 Deep thrombophlebitis NA BeFree Detail
0.002 Adenocarcinoma of lung (disorder) Neutrophil gelatinase-associated lipocalin (NGAL) and matrix metalloproteinase-9... BeFree 25542236 Detail
<0.001 esophageal carcinoma We found that the levels of PLGF in TE-1 cells positively affected the levels of... BeFree 25213700 Detail
<0.001 hypertensive heart disease NA BeFree Detail
<0.001 Idiopathic pulmonary hypertension NA BeFree Detail
0.007 Malignant neoplasm of mouth NA BeFree,GAD Detail
<0.001 Malignant neoplasm of nasopharynx NA BeFree Detail
<0.001 Malignant neoplasm of gallbladder NA BeFree Detail
0.002 Malignant neoplasm of brain NA GAD Detail
0.001 Secondary malignant neoplasm of lung In addition, knockdown of MMP9 resulted in inhibition of cell migration and inva... BeFree 25811800 Detail
0.001 Secondary malignant neoplasm of bone NA BeFree Detail
<0.001 Corneal pannus NA BeFree Detail
0.002 acute myocardial infarction Serum MMP-9 and CRP levels were significantly higher in the ACS group compared w... BeFree 24709882 Detail
<0.001 allergic asthma NA BeFree Detail
0.120 Intervertebral disc disorder NA CTD_human Detail
0.003 Colitis, Ischemic NA BeFree,LHGDN Detail
0.080 Right Ventricular Hypertrophy NA RGD Detail
<0.001 Cicatrix, Hypertrophic There was a significant upregulation of the mRNA expression of matrix metallopro... BeFree 25166894 Detail
0.080 Dermatitis, Allergic Contact NA RGD Detail
0.151 Aortic Aneurysm, Abdominal NA BeFree,CTD_human,GAD,LHGDN Detail
0.007 Tumor Progression NA BeFree Detail
<0.001 follicular adenoma NA BeFree Detail
<0.001 Diabetic Foot NA BeFree Detail
<0.001 Amyloid Neuropathies, Familial NA BeFree Detail
0.001 Giant Cell Tumor of Bone NA BeFree Detail
0.003 Adenomatous Polyps NA BeFree,LHGDN Detail
<0.001 Follicular thyroid carcinoma NA BeFree Detail
0.003 Carcinoma, Lobular NA LHGDN Detail
0.085 cholangiocarcinoma NA BeFree,LHGDN,RGD Detail
<0.001 Klatskin tumor NA BeFree Detail
<0.001 gliosarcoma NA BeFree Detail
<0.001 Angiofibroma NA BeFree Detail
0.001 Lip and oral cavity carcinoma NA BeFree Detail
<0.001 Metastatic malignant neoplasm to brain Importantly, high levels of TNF-α and RhoC-induced MMP9 were significantly corre... BeFree 25659578 Detail
<0.001 Adult type dermatomyositis NA BeFree Detail
<0.001 Premature aging syndrome NA BeFree Detail
<0.001 Fibrillation NA BeFree Detail
0.002 Spontaneous rupture of membranes NA GAD Detail
<0.001 Maladaptive behavior associated with physical illness NA BeFree Detail
<0.001 gallbladder carcinoma NA BeFree Detail
0.006 pancreatic carcinoma Silencing of Gli1 alone without external stimulus had no effect on EMT but inhib... BeFree 25979438 Detail
<0.001 Carcinoma of male breast NA BeFree Detail
<0.001 Colitis, Collagenous NA BeFree Detail
<0.001 Inclusion Body Myositis (disorder) NA BeFree Detail
<0.001 Cancer of Nasopharynx NA BeFree Detail
<0.001 Hereditary pancreatitis NA BeFree Detail
<0.001 Anaplastic thyroid carcinoma NA BeFree Detail
0.001 Papillary thyroid carcinoma Combined immunohistochemical evaluation of the levels of COX-2, MMP-9 and VEGF i... BeFree 24670538 Detail
<0.001 bone destruction NA BeFree Detail
0.002 Fibrosis, Liver Finally, the possible regulatory effect of fibronectin peptides in liver fibrosi... BeFree 24976518 Detail
0.002 Fibrosis, Liver Mutant MMP-9 and HGF gene transfer enhance resolution of CCl4-induced liver fibr... BeFree 25380300 Detail
<0.001 Iron deficiency NA BeFree Detail
<0.001 pelvic inflammatory disease NA BeFree Detail
0.018 Malignant neoplasm of lung DLK1 promotes lung cancer cell invasion through upregulation of MMP9 expression ... BeFree,GAD 24621612 Detail
0.018 Malignant neoplasm of lung In conclusion, we report that the shRNA-mediated knockdown of RhoGDI2 induces th... BeFree,GAD 25266803 Detail
0.018 Malignant neoplasm of lung For example, matrix metalloproteinase 9 (MMP9) is overexpressed in tumors, is kn... BeFree,GAD 25703655 Detail
0.018 Malignant neoplasm of lung Matrix metalloproteinase 9 (MMP9) expression is positively correlated with lung ... BeFree,GAD 25746000 Detail
0.001 primary angle-closure glaucoma Lack of association between the rs2664538 polymorphism in the MMP-9 gene and pri... BeFree 18552608 Detail
<0.001 Lyme Arthritis NA BeFree Detail
0.003 age related macular degeneration MMP9 is an important regulating enzyme in ECM metabolism, and the MMP9 gene may ... BeFree,GAD 25162123 Detail
0.002 Ventricular Dysfunction, Left NA GAD Detail
0.080 Hyperoxia NA RGD Detail
<0.001 Malignant neoplasm of male breast NA BeFree Detail
0.204 Sepsis NA BeFree,CTD_human,LHGDN,RGD Detail
<0.001 Malignant Meningioma NA BeFree Detail
<0.001 rhabdoid meningioma NA BeFree Detail
<0.001 Childhood asthma NA BeFree Detail
<0.001 Dilatation of aorta In the mouse CaCl2-induced AAA model, deficiency of myeloid TM, but not vascular... BeFree 26338301 Detail
<0.001 Cerebral Vasospasm NA BeFree Detail
0.007 Chronic Periodontitis NA BeFree,LHGDN Detail
<0.001 Intestinal metaplasia of gastric mucosa NA BeFree Detail
<0.001 Acute ischemic colitis NA BeFree Detail
<0.001 Endometrioma NA BeFree Detail
<0.001 Tuberculosis, Central Nervous System NA BeFree Detail
<0.001 Carcinoma breast stage IV NA BeFree Detail
<0.001 Breast cancer recurrent NA BeFree Detail
<0.001 Malignant neoplasm of stomach stage IV Furthermore, the down-regulation of NDRG1 in gastric cancer metastatic progressi... BeFree 24985974 Detail
<0.001 gastric adenocarcinoma NA BeFree Detail
<0.001 Metastatic melanoma NA BeFree Detail
<0.001 Non-small cell lung cancer metastatic NA BeFree Detail
0.001 Cancer of Head and Neck NA BeFree Detail
<0.001 Liver and Intrahepatic Biliary Tract Carcinoma NA BeFree Detail
<0.001 Lobular carcinoma in situ of breast NA BeFree Detail
0.002 Squamous cell carcinoma of esophagus Restoration of RUNX3 expression significantly inhibits ESCC cells migration, inv... BeFree 25428380 Detail
0.002 Squamous cell carcinoma of esophagus In conclusion, this study showed that the MMP2 -1306 TT and MMP9 -1562 CC genoty... BeFree 25966235 Detail
0.002 Squamous cell carcinoma of esophagus The present study demonstrated that GRP78 plays important roles in invasion and ... BeFree 25976624 Detail
0.002 Squamous cell carcinoma of esophagus As a consequence, activation of MMP-9 and the rearrangement of F-actin throw lig... BeFree 26190820 Detail
<0.001 Adenocarcinoma Of Esophagus MMP13 expression was highest in Barrett's metaplasia, whereas MMP9 was highest i... BeFree 25562781 Detail
<0.001 cervical squamous cell carcinoma NA BeFree Detail
<0.001 Transitional cell carcinoma of bladder NA BeFree Detail
<0.001 Conventional (Clear Cell) Renal Cell Carcinoma TNF-α enhanced migration and invasion of ccRCC cells together with down-regulati... BeFree 25123505 Detail
0.001 Solid tumour NA BeFree Detail
<0.001 stage, cervical cancer NA BeFree Detail
<0.001 Squamous cell carcinoma of oropharynx NA BeFree Detail
<0.001 laryngeal squamous cell carcinoma NA BeFree Detail
<0.001 Leiomyosarcoma of uterus NA BeFree Detail
<0.001 Prolapsed lumbar disc NA BeFree Detail
0.006 cervix carcinoma The prevalence of moderate to intense MMP-9 staining was 9% in normal cervical s... BeFree,GAD 24578283 Detail
<0.001 Dryness of eye Matrix metalloproteinase 9 and transglutaminase 2 expression at the ocular surfa... BeFree 25240629 Detail
<0.001 Dryness of eye In our experiments, elevated expression of MMP9 in dry eye subjects correlated w... BeFree 25703476 Detail
0.006 Restenosis NA BeFree,GAD Detail
<0.001 Microembolus An intragroup analysis of the time factor for the microemboli groups showed sign... BeFree 24962158 Detail
<0.001 Superficial ulcer NA BeFree Detail
<0.001 Senile Plaques NA BeFree Detail
<0.001 Tumor necrosis NA BeFree Detail
<0.001 Squamous intraepithelial lesion MMP-9 expression increases according to the grade of squamous intraepithelial le... BeFree 24578283 Detail
<0.001 High-Grade Squamous Intraepithelial Lesions The prevalence of moderate to intense MMP-9 staining was 9% in normal cervical s... BeFree 24578283 Detail
<0.001 Non-infiltrating lobular carcinoma NA BeFree Detail
<0.001 anaplastic astrocytoma NA BeFree Detail
<0.001 limbic encephalitis NA BeFree Detail
0.001 Glaucoma, Primary Open Angle NA BeFree Detail
0.121 Stable angina PTX3 expression, and MMP-9 and CRP levels in the SAP subgroup, were not signific... BeFree,CTD_human 24709882 Detail
0.121 Stable angina All these findings suggest that ACS patients have remarkably higher MMP-9, 1TIMP... BeFree,CTD_human 26122234 Detail
<0.001 Anterior myocardial infarction Serum MMP-9 and CRP levels were significantly higher in the ACS group compared w... BeFree 24709882 Detail
<0.001 Internal Carotid Artery Stenosis We found that interleukin (IL) 6 (IL-6), IL-1β, monocyte chemoattractant protein... BeFree 25441669 Detail
<0.001 Aortic aneurysm without mention of rupture NOS NA BeFree Detail
0.003 Dissection of aorta Association of the polymorphisms of MMP-9 and TIMP-3 genes with thoracic aortic ... BeFree,GAD 24487965 Detail
<0.001 Deep vein thrombosis of lower limb NA BeFree Detail
<0.001 Chronic liver disease NA BeFree Detail
<0.001 endometriosis of uterus NA BeFree Detail
0.001 Malignant neoplasm of liver BTG1 expression decreased in hepatocellular cancer and correlated significantly ... BeFree 25173640 Detail
<0.001 malignant mesothelioma NA BeFree Detail
<0.001 intestinal cancer NA BeFree Detail
0.005 Malignant neoplasm of pancreas Silencing of Gli1 alone without external stimulus had no effect on EMT but inhib... BeFree 25979438 Detail
<0.001 Disseminated Malignant Neoplasm NA BeFree Detail
<0.001 Squamous cell carcinoma of tongue miR-34a inhibits migration and invasion of tongue squamous cell carcinoma via ta... BeFree 25268950 Detail
<0.001 Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site NA BeFree Detail
<0.001 Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site NA BeFree Detail
0.024 Malignant neoplasm of prostate Our data showed that knockdown of SPAG9 in prostate cancer cell lines inhibited ... BeFree,GAD 25310386 Detail
0.024 Malignant neoplasm of prostate Overexpression of GRP78 upregulated the expression of MMP-9 and VEGFR2 in PC-3 a... BeFree,GAD 25794856 Detail
0.003 Multiple Sclerosis, Chronic Progressive NA LHGDN Detail
<0.001 Polyradiculoneuropathy, Chronic Inflammatory Demyelinating NA BeFree Detail
<0.001 Chronic Kidney Insufficiency NA BeFree Detail
0.005 Osteoarthritis, Knee NA BeFree,GAD,LHGDN Detail
<0.001 lupus erythematosus In this study, the possible association between MMP-9 and MMP-2 functional promo... BeFree 25416694 Detail
<0.001 Aortic valve calcification NA BeFree Detail
0.121 Metaphyseal anadysplasia Autosomal dominant (AD) MANDP has been described as more severe, and has been as... BeFree,ORPHANET 24781753 Detail
0.120 Mandibuloacral dysostosis NA BeFree,CTD_human Detail
<0.001 neuropathy NA BeFree Detail
<0.001 Complex Regional Pain Syndromes NA BeFree Detail
<0.001 Nevus elasticus NA BeFree Detail
0.005 endometrial carcinoma The relationships between the immunoexpression of KAI1, MMP-2, MMP-9 and steroid... BeFree,GAD 25308734 Detail
0.003 Secondary malignant neoplasm of liver The expression of six genes was significantly different in primary tumors compar... BeFree 25301403 Detail
0.003 Secondary malignant neoplasm of liver Our experimental results suggest that HCS has some anti-metastasis potential to ... BeFree 25496480 Detail
0.003 dementia NA BeFree,GAD Detail
<0.001 Overweight NA BeFree Detail
<0.001 acute pyelonephritis NA BeFree Detail
<0.001 Sleep Apnea, Obstructive Functional polymorphisms in the promoter region of MMP-2 and MMP-9 and susceptib... BeFree 25753939 Detail
<0.001 Recurrent tumor NA BeFree Detail
<0.001 Metabolic syndrome X The MMP-9 -1562 C/T polymorphism in the presence of metabolic syndrome increases... BeFree 25191702 Detail
0.003 Hepatitis B, Chronic NA LHGDN Detail
0.005 Hepatitis C, Chronic NA BeFree,GAD Detail
0.002 Mood Disorders NA GAD Detail
<0.001 Malignant neoplasm of esophagus We found that the levels of PLGF in TE-1 cells positively affected the levels of... BeFree 25213700 Detail
<0.001 Thyroid carcinoma NA BeFree Detail
<0.001 Necrotizing Arteritis NA BeFree Detail
0.002 Brain hemorrhage NA GAD Detail
<0.001 Oropharyngeal disorders NA BeFree Detail
<0.001 Squamous cell carcinoma of skin Moreover, the suppressive role of miR-199a in cell migration in cSCC cells was a... BeFree 25400809 Detail
0.001 Malignant glioma NA BeFree Detail
0.003 Carotid Atherosclerosis NA BeFree,GAD Detail
0.006 Osteosarcoma of bone Knockdown of GAL1 suppressed cell proliferative activities and invasive potentia... BeFree 25069486 Detail
0.006 Osteosarcoma of bone Overexpression of RASSF5 markedly suppressed cell proliferation and invasion, an... BeFree 25109282 Detail
0.006 Osteosarcoma of bone We then examined the effect of HN.49 on the enzyme activity of MMP9 and the migr... BeFree 25177029 Detail
0.006 Osteosarcoma of bone Thus, miR-143, EGFR, and MMP9 are therapeutic targets for inhibiting OS invasion... BeFree 25227664 Detail
0.006 Osteosarcoma of bone ERK5 silencing inhibits invasion of human osteosarcoma cell via modulating the S... BeFree 25317798 Detail
0.006 Osteosarcoma of bone Our findings suggested that HEY1 augmented the metastasis of osteosarcoma via up... BeFree 25742474 Detail
<0.001 Carcinoma of larynx NA BeFree Detail
0.005 Carcinogenesis In summary, AR overexpression induced by AKT phosphorylation upregulated MMP9 by... BeFree 25301736 Detail
<0.001 hyperhomocysteinemia NA BeFree Detail
<0.001 Leukemogenesis NA BeFree Detail
0.030 coronary artery disease Although results thus far are inconsistent, meta-analysis has demonstrated that ... BeFree 24938016 Detail
0.015 prostate carcinoma Our data showed that knockdown of SPAG9 in prostate cancer cell lines inhibited ... BeFree 25310386 Detail
0.015 prostate carcinoma Overexpression of GRP78 upregulated the expression of MMP-9 and VEGFR2 in PC-3 a... BeFree 25794856 Detail
0.002 hepatopulmonary syndrome NA GAD Detail
0.002 Epithelial ovarian cancer Downregulation of matrix metalloproteinase 9 by small interfering RNA inhibits t... BeFree 25738807 Detail
<0.001 Progressive Neoplastic Disease NA BeFree Detail
<0.001 Stage IV Colorectal Cancer NA BeFree Detail
0.029 breast carcinoma In the present study, we demonstrate that green tea polyphenols (GTP) and its ma... BeFree 24481780 Detail
0.029 breast carcinoma In addition, CXCR7 regulated breast cancer metastasis by enhancing expression of... BeFree 24886617 Detail
0.029 breast carcinoma Delphinidin suppresses PMA-induced MMP-9 expression by blocking the NF-κB activa... BeFree 25000305 Detail
0.029 breast carcinoma MMP-9 expression varies according to molecular subtypes of breast cancer. BeFree 25151367 Detail
0.029 breast carcinoma The results suggested that the anticancer properties of ginsenoside Rg1 may deri... BeFree 25174454 Detail
0.029 breast carcinoma Celastrol induces the apoptosis of breast cancer cells and inhibits their invasi... BeFree 25310109 Detail
0.029 breast carcinoma These results indicate that Ethyl gallate suppresses proliferation and invasion ... BeFree 25522911 Detail
0.029 breast carcinoma Protein arginine methyltransferase 7 promotes breast cancer cell invasion throug... BeFree 25605249 Detail
0.029 breast carcinoma Mechanistically, eIF4E silencing or blockade reduced the invasiveness and metast... BeFree 25608710 Detail
0.029 breast carcinoma Taken together, our findings indicate that the MMP-9 inhibitory activity of glau... BeFree 25670016 Detail
0.029 breast carcinoma Matrix metalloproteinase-9 -1562T allele and its combination with MMP-2 -735 C a... BeFree 25735351 Detail
0.029 breast carcinoma Taken together, this work identified the TSP50 activation of MMP9 as a novel sig... BeFree 25811800 Detail
0.029 breast carcinoma Association between four MMP-9 polymorphisms and breast cancer risk: a meta-anal... BeFree 25890491 Detail
<0.001 Vascular rupture NA BeFree Detail
0.010 Carcinoma of lung DLK1 promotes lung cancer cell invasion through upregulation of MMP9 expression ... BeFree 24621612 Detail
0.010 Carcinoma of lung In conclusion, we report that the shRNA-mediated knockdown of RhoGDI2 induces th... BeFree 25266803 Detail
0.010 Carcinoma of lung These results suggested that PFIO could suppress the invasion and migration of h... BeFree 25270791 Detail
0.010 Carcinoma of lung For example, matrix metalloproteinase 9 (MMP9) is overexpressed in tumors, is kn... BeFree 25703655 Detail
0.010 Carcinoma of lung Matrix metalloproteinase 9 (MMP9) expression is positively correlated with lung ... BeFree 25746000 Detail
<0.001 Malignant neoplasm of gastrointestinal tract NA BeFree Detail
0.007 Secondary malignant neoplasm of lymph node miR-34a plays an important role in lymph node metastases of TSCC through targeti... BeFree 25268950 Detail
0.007 Secondary malignant neoplasm of lymph node In addition, the expression of SMYD3 was correlated with size of primary tumor a... BeFree 25627005 Detail
0.007 Secondary malignant neoplasm of lymph node Gli1 expression was associated positively with tumor T (P = .025) and Union for ... BeFree 25979438 Detail
<0.001 Community acquired pneumonia NA BeFree Detail
<0.001 Recurrent pneumonia NA BeFree Detail
0.005 colon carcinoma In this study, we demonstrated that β6 integrin induced the expression of MMP-3/... BeFree 25135220 Detail
0.012 stomach carcinoma CXCR1, CXCR2, and MMP9 were expressed in 61.0%, 77.9%, and 75.6% of gastric canc... BeFree 25022956 Detail
0.012 stomach carcinoma Calcium/calmodulin‑dependent protein kinase II enhances metastasis of human gast... BeFree 25174603 Detail
0.012 stomach carcinoma Moreover, ALDH1A1 was significantly correlated with MMP-9 among 216 gastric canc... BeFree 25253129 Detail
0.012 stomach carcinoma The AKT/AR/MMP9 pathway plays an important role in GC metastasis and may be a no... BeFree 25301736 Detail
0.012 stomach carcinoma Knockdown of EGFR reduced cell proliferation and invasion of GC with decreased e... BeFree 25394504 Detail
0.012 stomach carcinoma Additionally, CEACAM6 elevated matrix metalloproteinase-9 (MMP-9) activity in GC... BeFree 25398131 Detail
0.012 stomach carcinoma Fz2 shRNA suppressed cell proliferation and motility of MKN45 and MKN74 cells, a... BeFree 25586465 Detail
0.012 stomach carcinoma The HER-2 positive SGC-7901 secreted more transforming growth factor beta 1 (TGF... BeFree 25613482 Detail
0.012 stomach carcinoma Overexpression of SMYD3 and matrix metalloproteinase-9 are associated with poor ... BeFree 25627005 Detail
0.012 stomach carcinoma MMP-9 is increased in the pathogenesis of gastric cancer by the mediation of HER... BeFree 25633484 Detail
0.012 stomach carcinoma Activation of matrix metalloproteinase-9 (MMP-9) by neurotensin promotes cell in... BeFree 25724188 Detail
0.012 stomach carcinoma WISP-2 suppressed GC cell metastasis through reversing EMT and suppressing the e... BeFree 26291058 Detail
0.005 Carcinoma of bladder NA BeFree Detail
0.003 Central neuroblastoma Gain- and loss-of-function studies indicated that secretory ITLN1 facilitated th... BeFree 25889839 Detail
<0.001 Dissecting aneurysm of the thoracic aorta Association of the polymorphisms of MMP-9 and TIMP-3 genes with thoracic aortic ... BeFree 24487965 Detail
<0.001 Subfertility NA BeFree Detail
<0.001 Microalbuminuria In diabetic patients, the upregulation of urinary MMP-9 concentrations occurred ... BeFree 24670409 Detail
0.120 Infarction, Middle Cerebral Artery NA CTD_human Detail
<0.001 Chronic lung disease NA BeFree Detail
0.001 early pregnancy NA BeFree Detail
<0.001 Encephalitis, West Nile Fever NA BeFree Detail
<0.001 Malignant Squamous Cell Neoplasm NA BeFree Detail
0.002 Carotid Artery, Internal, Dissection NA GAD Detail
<0.001 Acute Cerebrovascular Accidents NA BeFree Detail
0.003 Multiple Sclerosis, Relapsing-Remitting NA LHGDN Detail
0.001 malignant pleural mesothelioma NA BeFree Detail
<0.001 Helicobacter pylori infection NA BeFree Detail
0.005 Pregnancy associated hypertension NA LHGDN Detail
<0.001 Invasive breast carcinoma NA BeFree Detail
<0.001 Diabetic Cardiomyopathies Here, we describe the method to generate Ins2+/-/Mmp9-/- (DKO) mice to determine... BeFree 25064116 Detail
<0.001 Endothelial dysfunction NA BeFree Detail
0.001 Post MI Our data suggest that MMP-9 deletion improves mitochondrial function post-MI. BeFree 24382150 Detail
<0.001 Aneurysm of ascending aorta NA BeFree Detail
<0.001 breast adenocarcinoma NA BeFree Detail
0.003 Pelvic Organ Prolapse NA BeFree,GAD Detail
<0.001 Asthma chronic NA BeFree Detail
<0.001 conjunctivochalasis NA BeFree Detail
<0.001 Stromal Neoplasm NA BeFree Detail
0.002 Cerebral Ischemia NA BeFree Detail
0.013 ovarian neoplasm NA BeFree,LHGDN Detail
<0.001 Metastatic Prostate Carcinoma NA BeFree Detail
<0.001 precancerous lesions NA BeFree Detail
<0.001 cholecystolithiasis NA BeFree Detail
<0.001 Ischemic stroke NA BeFree Detail
0.134 Acute coronary syndrome Pentraxin 3, long expression in mononuclear cells of patients with acute coronar... BeFree,CTD_human,GAD,LHGDN 24709882 Detail
0.003 Leukoaraiosis NA LHGDN Detail
<0.001 Primary infection NOS NA BeFree Detail
<0.001 Colorectal cancer metastatic NA BeFree Detail
0.080 Arthritis, Experimental NA RGD Detail
<0.001 West Nile viral infection NA BeFree Detail
<0.001 Chlamydia pneumoniae infection Berberine inhibits Chlamydia pneumoniae infection-induced vascular smooth muscle... BeFree 25746423 Detail
<0.001 Anterior subcapsular cataract NA BeFree Detail
<0.001 Invasive Ductal Breast Carcinoma NA BeFree Detail
0.011 Malignant neoplasm of ovary The results demonstrated that siRNA-mediated knockdown of MMP-9 in the human ova... BeFree,GAD 25738807 Detail
<0.001 Abdominal sepsis NA BeFree Detail
<0.001 Corneal melt NA BeFree Detail
0.003 Squamous cell carcinoma of the head and neck NA BeFree Detail
0.080 ileus NA RGD Detail
0.005 Stenosis NA GAD,LHGDN Detail
0.004 sarcoma NA BeFree,LHGDN Detail
<0.001 Postnatal infection NA BeFree Detail
<0.001 Chronic myeloproliferative disorder MMP2 gene-735 C/T and MMP9 gene -1562 C/T polymorphisms in JAK2V617F positive my... BeFree 25684469 Detail
<0.001 Adenoma of large intestine NA BeFree Detail
<0.001 Low Grade Squamous Intraepithelial Neoplasia Thus, the expression of MMP-9 in cervical smears increases according to the grad... BeFree 24578283 Detail
<0.001 Aggressive Non-Hodgkin Lymphoma NA BeFree Detail
<0.001 Invasive Carcinoma NA BeFree Detail
0.003 pulmonary sclerosing hemangioma NA BeFree,LHGDN Detail
<0.001 mesenchymal cell neoplasm NA BeFree Detail
<0.001 Ovarian Serous Adenocarcinoma Ovarian serous carcinomas (n=112) and solid metastases (n=63; total=175) were an... BeFree 26232338 Detail
<0.001 pancreatic ductal adenocarcinoma Mechanistically, silencing of SENP1 results in downregulation of MMP-9, which is... BeFree 25217324 Detail
<0.001 Pericytic Neoplasm NA BeFree Detail
<0.001 Thymic Lymphoma NA BeFree Detail
<0.001 Hypopharyngeal Carcinoma Serum levels of MMP1, MMP2, and MMP9 were analyzed in patients with oropharyngea... BeFree 25503184 Detail
<0.001 Epithelioma NA BeFree Detail
<0.001 Cardiac fibrosis Activated Mmp9 degrades extracellular matrix (ECM) and increases matrix turnover... BeFree 25064116 Detail
<0.001 Vascular lesions NA BeFree Detail
<0.001 Cardiomyopathy, Familial Idiopathic NA BeFree Detail
<0.001 Diabetic foot ulcer NA BeFree Detail
0.177 Mammary Neoplasms NA BeFree,CTD_human,LHGDN Detail
<0.001 drug dependence NA BeFree Detail
<0.001 Angiogenic Switch NA BeFree Detail
<0.001 Breast Cancer Model NA BeFree Detail
<0.001 Desmoplastic NA BeFree Detail
<0.001 Primary Glioblastoma NA BeFree Detail
<0.001 Malignant Conversion NA BeFree Detail
<0.001 Skin Carcinogenesis NA BeFree Detail
0.003 Tumor Angiogenesis MMP9 also enhances PKD2-mediated tumor angiogenesis releasing extracellular matr... BeFree 24847910 Detail
<0.001 Xenograft Model NA BeFree Detail
0.021 colorectal cancer Interestingly, Nur77-mediated CRC invasion via MMP-9 and E-cadherin could be mim... BeFree,GAD 25064356 Detail
0.021 colorectal cancer At last, in the tumor samples from patients with locally advanced colorectal can... BeFree,GAD 25205654 Detail
0.021 colorectal cancer Our results suggest that DIM can influence the cell migratory and invasive prope... BeFree,GAD 25962429 Detail
0.200 brain edema NA CTD_human,RGD Detail
0.002 Sjogren's syndrome NA GAD Detail
<0.001 Neoplasms, Intracranial NA BeFree Detail
<0.001 Chronic Kidney Diseases NA BeFree Detail
<0.001 Non-ST elevation (NSTEMI) myocardial infarction NA BeFree Detail
<0.001 Alport syndrome NA BeFree Detail
<0.001 Tendinopathy NA BeFree Detail
0.001 Glioblastoma multiforme A significant decline of MMP-9 and MMP-2 secretion in cultured U87MG was detecte... BeFree 25256634 Detail
0.001 Glioblastoma multiforme Overexpression and knockdown of PODX respectively reversed and enhanced the inhi... BeFree 25708368 Detail
<0.001 Cirrhosis NA BeFree Detail
<0.001 androgen independent prostate cancer In a previous study, penta-O-galloyl-β-D-glucose (PGG) suppressed androgen-indep... BeFree 25123845 Detail
<0.001 tumor vasculature NA BeFree Detail
<0.001 Benign Prostatic Hyperplasia NA BeFree Detail
<0.001 Enchondroma NA BeFree Detail
<0.001 Non-Neoplastic Disorder NA BeFree Detail
<0.001 Aggressive periodontitis, generalized NA BeFree Detail
<0.001 Generalized chronic periodontitis NA BeFree Detail
0.001 Meningioma, benign, no ICD-O subtype Deficiency of the protein-tyrosine phosphatase DEP-1/PTPRJ promotes matrix metal... BeFree 25672645 Detail
<0.001 Idiopathic Pulmonary Fibrosis MMPs and their inhibitors, tissue inhibitors of MMPs (TIMPs), have been implicat... BeFree 26121236 Detail
<0.001 TIBIAL MUSCULAR DYSTROPHY, TARDIVE A statistically significant difference in genotype and allele frequencies was fo... BeFree 26244436 Detail
<0.001 Aortic root dilation NA BeFree Detail
<0.001 PNEUMOTHORAX, PRIMARY SPONTANEOUS By IHC, higher expression of MMP-2 and MMP-9 in PSP patients was identified in a... BeFree 25300296 Detail
<0.001 ALKALINE PHOSPHATASE, PLASMA LEVEL OF, QUANTITATIVE TRAIT LOCUS 1 NA BeFree Detail
0.002 uterine corpus cancer The relationships between the immunoexpression of KAI1, MMP-2, MMP-9 and steroid... BeFree 25308734 Detail
0.030 coronary artery disease The MMP-9 -1562 C/T polymorphism in the presence of metabolic syndrome increases... BeFree,GAD,LHGDN 25191702 Detail
0.030 coronary artery disease Moreover, COL14A1 and MMP9 DNA methylation levels were associated with CAD, age ... BeFree,GAD,LHGDN 25687463 Detail
<0.001 Parvovirus B19 (disease) NA BeFree Detail
<0.001 Acute lyme disease NA BeFree Detail
0.003 Precursor Cell Lymphoblastic Leukemia Lymphoma NA BeFree,LHGDN Detail
<0.001 Postmenopausal endometrium NA BeFree Detail
<0.001 eyelids (symptom) Compared with a 1-time measurement of 8 healthy participants, among 16 symptomat... BeFree 26204109 Detail
0.159 liver carcinoma FOXA2 suppresses the metastasis of hepatocellular carcinoma partially through ma... BeFree,CTD_human,GAD,LHGDN 25142974 Detail
0.159 liver carcinoma Metformin was also found to significantly inhibit the expression and secretion o... BeFree,CTD_human,GAD,LHGDN 25245054 Detail
0.159 liver carcinoma People with significantly elevated serum levels of MMP-9 are at risk of developi... BeFree,CTD_human,GAD,LHGDN 25299117 Detail
0.159 liver carcinoma Moreover, NS3 enhanced hepatoma cell invasion and migration through MMP-9 and CO... BeFree,CTD_human,GAD,LHGDN 25305454 Detail
0.159 liver carcinoma Matrix metalloproteinase (MMP)2 and MMP9 activity was involved partly in the GEP... BeFree,CTD_human,GAD,LHGDN 25315249 Detail
0.159 liver carcinoma In this study, we report that MUC1 overexpression enhanced the levels of phospho... BeFree,CTD_human,GAD,LHGDN 25526895 Detail
0.159 liver carcinoma Hepatoprotective and anti-tumor effects of targeting MMP-9 in hepatocellular car... BeFree,CTD_human,GAD,LHGDN 25999065 Detail
<0.001 Chronic kidney disease stage 5 NA BeFree Detail
<0.001 Mycetoma of foot NA BeFree Detail
0.001 Allergic rhinitis (disorder) NA BeFree Detail
0.002 Airway Remodeling NA GAD Detail
<0.001 Alcoholic Steatohepatitis NA BeFree Detail
0.120 Metaphyseal anadysplasia 2 NA CTD_human Detail
0.002 Infection of amniotic sac and membranes, unspecified, unspecified trimester, not applicable or unspecified NA GAD Detail
<0.001 Collagenopathy, type 2 alpha 1 NA BeFree Detail
0.004 Nasopharyngeal carcinoma NA BeFree Detail
<0.001 Obesity, Visceral NA BeFree Detail
<0.001 Plaque, Amyloid NA BeFree Detail
0.120 Neointima NA CTD_human Detail
0.120 Cerebral Hemorrhage NA CTD_human Detail
<0.001 aggressive cancer NA BeFree Detail
<0.001 Pulmonary arterial hypertension NA BeFree Detail
<0.001 Stage IV Colorectal Cancer AJCC v7 NA BeFree Detail
<0.001 Papillary Meningioma NA BeFree Detail
<0.001 Valvular disease NA BeFree Detail
<0.001 Ischemic Cerebrovascular Accident NA BeFree Detail
0.003 myelodysplastic syndrome NA BeFree,LHGDN Detail
<0.001 FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder) IL-6, IL-8, MMP-2, MMP-9 are overexpressed in Fanconi anemia cells through a NF-... BeFree 25358651 Detail
<0.001 Homocysteinemia NA BeFree Detail
<0.001 Progressive cGVHD NA BeFree Detail
<0.001 Triple Negative Breast Neoplasms NA BeFree Detail
<0.001 aortic valve disease 2 NA BeFree Detail
<0.001 Neutrophilia (disorder) NA BeFree Detail
<0.001 Astrocytoma of brain NA BeFree Detail
0.016 Infection NA GAD,LHGDN Detail
<0.001 Fibromyxosarcoma NA BeFree Detail
0.080 Respirovirus Infections NA RGD Detail
<0.001 Pulmonary hypertension, primary, 1, with hereditary hemorrhagic telangiectasia NA BeFree Detail
<0.001 Portal fibrosis NA BeFree Detail
<0.001 Experimental Organism Basal Cell Carcinoma NA BeFree Detail
0.003 Acantholysis NA LHGDN Detail
0.002 acquired immunodeficiency syndrome NA GAD Detail
0.012 adenocarcinoma NA BeFree,LHGDN Detail
0.002 adenoma We analyzed 57 prolactinoma patients classified as having invasive and noninvasi... BeFree 26071077 Detail
<0.001 AIDS Dementia Complex NA BeFree Detail
<0.001 Airway Obstruction Overexpression of MMP-9 in lung tissue and its interaction with CAP1 is likely t... BeFree 25332229 Detail
0.003 Alcoholic Intoxication, Chronic NA BeFree,GAD Detail
0.003 Alzheimer's disease NA BeFree,GAD Detail
<0.001 ameloblastoma EGF, MMP2, and MMP9 expression in ameloblastoma biopsies and in the AME-HPV cell... BeFree 25099616 Detail
<0.001 amyloidosis NA BeFree Detail
0.006 amyotrophic lateral sclerosis NA BeFree,GAD,LHGDN Detail
<0.001 Congenital Pain Insensitivity It is likely that the aberrantly accelerated MMP-9 proteolysis during neurogenes... BeFree 26283785 Detail
<0.001 Anaplasia Matrix metalloproteinase-9 deficiency attenuates diabetic nephropathy by modulat... BeFree 24670409 Detail
0.013 Aneurysm Pharmacological inhibition of 5-LO-attenuated aneurysm formation in both aortic ... BeFree,GAD,LHGDN 25324573 Detail
0.013 Aneurysm Since the clinical manifestations in Behçet disease (BD) include aneurysm format... BeFree,GAD,LHGDN 25639450 Detail
0.013 Aneurysm Matrix metalloproteinase-9 (MMP-9, Gelantinase B) has been shown to relate to st... BeFree,GAD,LHGDN 25932641 Detail
0.002 Angina Pectoris NA GAD Detail
0.005 Anoxia NA LHGDN Detail
0.129 aortic aneurysm NA BeFree,CTD_human,LHGDN Detail
0.120 Aortic Diseases NA CTD_human Detail
0.120 Aortic Rupture NA CTD_human Detail
<0.001 aortic valve stenosis NA BeFree Detail
<0.001 Arterial Occlusive Diseases NA BeFree Detail
0.086 arteriosclerosis NA BeFree,RGD Detail
0.080 Arteriovenous fistula NA BeFree,RGD Detail
<0.001 Congenital arteriovenous malformation After the monolayer adherent ECs reached confluence, they were tested with endot... BeFree 24771337 Detail
<0.001 Arthralgia NA BeFree Detail
<0.001 arthritis NA BeFree Detail
0.003 Arthritis, Gouty NA LHGDN Detail
0.012 rheumatoid arthritis The synthesis and secretion of MMP-9 can be stimulated by a variety of stimuli, ... BeFree,GAD,LHGDN 25000305 Detail
0.003 Ascites NA LHGDN Detail
<0.001 Aspergillosis, Allergic Bronchopulmonary NA BeFree Detail
0.226 asthma Prolonged Treatment with Inhaled Corticosteroids does not Normalize High Activit... BeFree,CTD_human,GAD,LHGDN,RGD 25650123 Detail
0.125 Astrocytoma NA BeFree,CTD_human,LHGDN Detail
<0.001 ataxia telangiectasia NA BeFree Detail
0.024 atherosclerosis NA BeFree,GAD,LHGDN Detail
0.002 atrial fibrillation NA GAD Detail
0.004 Autoimmune Diseases NA BeFree,LHGDN Detail
<0.001 Bacterial Infections NA BeFree Detail
<0.001 Barrett esophagus MMP activity was further validated in Barrett's esophagus and esophageal adenoca... BeFree 25562781 Detail
0.003 Behcet Syndrome Association of MMP-9 gene polymorphisms with Behçet's disease risk. BeFree,GAD 25639450 Detail
0.003 bipolar disorder NA BeFree,GAD Detail
0.012 Malignant neoplasm of urinary bladder NA BeFree,GAD Detail
0.005 Bladder Neoplasm NA LHGDN Detail
<0.001 Blast Phase NA BeFree Detail
<0.001 Bone Diseases NA BeFree Detail
0.121 Bone neoplasms NA BeFree,CTD_human Detail
<0.001 borderline personality disorder NA BeFree Detail
0.004 Brain Neoplasms NA BeFree,LHGDN Detail
0.038 Malignant neoplasm of breast In the present study, we demonstrate that green tea polyphenols (GTP) and its ma... BeFree,GAD 24481780 Detail
0.038 Malignant neoplasm of breast In addition, CXCR7 regulated breast cancer metastasis by enhancing expression of... BeFree,GAD 24886617 Detail
0.038 Malignant neoplasm of breast Delphinidin suppresses PMA-induced MMP-9 expression by blocking the NF-κB activa... BeFree,GAD 25000305 Detail
0.038 Malignant neoplasm of breast MMP-9 expression varies according to molecular subtypes of breast cancer. BeFree,GAD 25151367 Detail
0.038 Malignant neoplasm of breast The results suggested that the anticancer properties of ginsenoside Rg1 may deri... BeFree,GAD 25174454 Detail
0.038 Malignant neoplasm of breast Celastrol induces the apoptosis of breast cancer cells and inhibits their invasi... BeFree,GAD 25310109 Detail
0.038 Malignant neoplasm of breast These results indicate that Ethyl gallate suppresses proliferation and invasion ... BeFree,GAD 25522911 Detail
0.038 Malignant neoplasm of breast Protein arginine methyltransferase 7 promotes breast cancer cell invasion throug... BeFree,GAD 25605249 Detail
0.038 Malignant neoplasm of breast Mechanistically, eIF4E silencing or blockade reduced the invasiveness and metast... BeFree,GAD 25608710 Detail
0.038 Malignant neoplasm of breast Taken together, our findings indicate that the MMP-9 inhibitory activity of glau... BeFree,GAD 25670016 Detail
0.038 Malignant neoplasm of breast Matrix metalloproteinase-9 -1562T allele and its combination with MMP-2 -735 C a... BeFree,GAD 25735351 Detail
0.038 Malignant neoplasm of breast Taken together, this work identified the TSP50 activation of MMP9 as a novel sig... BeFree,GAD 25811800 Detail
0.038 Malignant neoplasm of breast Association between four MMP-9 polymorphisms and breast cancer risk: a meta-anal... BeFree,GAD 25890491 Detail
<0.001 Breast Diseases NA BeFree Detail
0.003 bronchiectasis NA BeFree,GAD Detail
0.003 bronchiolitis obliterans NA LHGDN Detail
0.006 bronchopulmonary dysplasia NA BeFree,LHGDN Detail
0.120 calcinosis NA CTD_human Detail
0.005 Malignant tumor of colon In this study, we demonstrated that β6 integrin induced the expression of MMP-3/... BeFree 25135220 Detail
0.002 Malignant neoplasm of endometrium The relationships between the immunoexpression of KAI1, MMP-2, MMP-9 and steroid... BeFree 25308734 Detail
<0.001 Malignant neoplasm of larynx NA BeFree Detail
<0.001 Adenocarcinoma of prostate NA BeFree Detail
<0.001 Rectal Carcinoma NA BeFree Detail
<0.001 Malignant neoplasm of skin NA BeFree Detail
<0.001 Malignant neoplasm of thyroid NA BeFree Detail
0.002 basal cell carcinoma NA GAD Detail
0.001 Noninfiltrating Intraductal Carcinoma NA BeFree Detail
0.131 Non-small cell lung carcinoma Expression of high mobility group box - B1 (HMGB-1) and matrix metalloproteinase... BeFree,CTD_human,GAD 24998555 Detail
0.131 Non-small cell lung carcinoma SEMA4b inhibits MMP9 to prevent metastasis of non-small cell lung cancer. BeFree,CTD_human,GAD 25095981 Detail
0.131 Non-small cell lung carcinoma Correlations of lysyl oxidase with MMP2/MMP9 expression and its prognostic value... BeFree,CTD_human,GAD 25337249 Detail
0.131 Non-small cell lung carcinoma Thus, our data highlight a coordinating relationship between VEGF-B and MMP9 in ... BeFree,CTD_human,GAD 25424698 Detail
0.131 Non-small cell lung carcinoma Knockdown of GOLPH3 significantly suppressed the migratory and invasive ability ... BeFree,CTD_human,GAD 25659977 Detail
0.131 Non-small cell lung carcinoma MiR-129 regulates MMP9 to control metastasis of non-small cell lung cancer. BeFree,CTD_human,GAD 25716201 Detail
0.131 Non-small cell lung carcinoma We have recently shown that Semaphorin 4B (SEMA4B) inhibits the invasion of non-... BeFree,CTD_human,GAD 25746385 Detail
0.005 renal cell carcinoma NA BeFree,LHGDN Detail
Annotation

Annotations

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A remarkable finding in the present study is the previously unrecognized association of MMP-9 with d... DisGeNET Detail
In this study, the possible association between MMP-9 and MMP-2 functional promoter polymorphism, st... DisGeNET Detail
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Butein ameliorated colitis in IL-10(-/-) mice by regulating IL-6/STAT3 and MMP-9 activation. DisGeNET Detail
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Interestingly, Nur77-mediated CRC invasion via MMP-9 and E-cadherin could be mimicked by some metast... DisGeNET Detail
At last, in the tumor samples from patients with locally advanced colorectal cancer with routine pos... DisGeNET Detail
Our results suggest that DIM can influence the cell migratory and invasive properties of human color... DisGeNET Detail
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The MMP-9 -1562 C/T polymorphism in the presence of metabolic syndrome increases the risk of clinica... DisGeNET Detail
The MMP-9 -1562 C/T polymorphism in the presence of metabolic syndrome increases the risk of clinica... DisGeNET Detail
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The expression of PRRs (Toll-like receptors and melanoma differentiation-associated gene 5) was indu... DisGeNET Detail
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Genes that were upregulated in VaD were MMP9 and VEGFA. DisGeNET Detail
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One of the important genes involved in extracellular matrix (ECM) remodeling in diabetes is matrix m... DisGeNET Detail
One of the important genes involved in extracellular matrix (ECM) remodeling in diabetes is matrix m... DisGeNET Detail
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Matrix metalloproteinase-9 deficiency attenuates diabetic nephropathy by modulation of podocyte func... DisGeNET Detail
Coincident with these changes in receptor expression but not activity, MMP-9 was also up-regulated i... DisGeNET Detail
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Matrix metalloproteinase 9 and transglutaminase 2 expression at the ocular surface in patients with ... DisGeNET Detail
In our experiments, elevated expression of MMP9 in dry eye subjects correlated with the ability of a... DisGeNET Detail
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We found that the levels of PLGF in TE-1 cells positively affected the levels of MMP9, while the lev... DisGeNET Detail
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IL-6, IL-8, MMP-2, MMP-9 are overexpressed in Fanconi anemia cells through a NF-κB/TNF-α dependent m... DisGeNET Detail
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Galangin and kaempferol suppress phorbol-12-myristate-13-acetate-induced matrix metalloproteinase-9 ... DisGeNET Detail
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Pharmacogenetic inhibition of eIF4E-dependent Mmp9 mRNA translation reverses fragile X syndrome-like... DisGeNET Detail
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A significant decline of MMP-9 and MMP-2 secretion in cultured U87MG was detected after incubation w... DisGeNET Detail
TWEAK also promotes noncanonical NFκB-dependent MMP9 expression and glioma cell invasion. DisGeNET Detail
Meanwhile, mangiferin specifically promoted the expression of miR-15b and suppressed the level of MM... DisGeNET Detail
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In this review, we discuss mitochondrial dynamics, its relation to MMP-9 and Cx-43, and the therapeu... DisGeNET Detail
Activated Mmp9 degrades extracellular matrix (ECM) and increases matrix turnover causing cardiac fib... DisGeNET Detail
In this review, we discuss mitochondrial dynamics, its relation to MMP-9 and Cx-43, and the therapeu... DisGeNET Detail
Activated Mmp9 degrades extracellular matrix (ECM) and increases matrix turnover causing cardiac fib... DisGeNET Detail
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It was concluded that patients with the MMP-9 TT genotype are at risk of developing HCC and HBV or H... DisGeNET Detail
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The association between MMP-9 gene polymorphisms and HCC patients with hepatitis C and B viruses (HC... DisGeNET Detail
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MMP-9 (C/T + T/T) genotype increased risk of hypertension in SLE patients 2.71-fold. DisGeNET Detail
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Collagen transcripts were also reduced in KC while MMP9 transcript levels were upregulated and corre... DisGeNET Detail
Elevated expression of matrix metalloproteinase-9 and inflammatory cytokines in keratoconus patients... DisGeNET Detail
However, MMP-9 knockout in diabetic mice significantly attenuated these nephropathy changes. DisGeNET Detail
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NFκB- and AP-1-mediated DNA looping regulates matrix metalloproteinase-9 transcription in TNF-α-trea... DisGeNET Detail
Matrix metalloproteinase-9 is involved in chronic lymphocytic leukemia cell response to fludarabine ... DisGeNET Detail
Secreted matrix metalloproteinases (MMP)-2 and MMP-9 and membrane-anchored aminopeptidase-N/CD13 are... DisGeNET Detail
We recently found that the tetraspanin family member, CD82, which is aberrantly expressed in chemoth... DisGeNET Detail
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The spread and metastases of ATL as well as other tumors has been associated with matrix metalloprot... DisGeNET Detail
The spread and metastases of ATL as well as other tumors has been associated with matrix metalloprot... DisGeNET Detail
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Moreover, NS3 enhanced hepatoma cell invasion and migration through MMP-9 and COX-2. DisGeNET Detail
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Relationship between expression of matrix metalloproteinase-9 and adenylyl cyclase-associated protei... DisGeNET Detail
Importantly, we demonstrate the feasibility of MMP9-controlled drug release in human lung tumors. DisGeNET Detail
In this study, the possible association between MMP-9 and MMP-2 functional promoter polymorphism, st... DisGeNET Detail
In this study, the possible association between MMP-9 and MMP-2 functional promoter polymorphism, st... DisGeNET Detail
Matrix metalloproteinase 9 polymorphisms and systemic lupus erythematosus: correlation with systemic... DisGeNET Detail
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Matrix metalloproteinase-9 polymorphism 1562 C > T (rs3918242) associated with protection against pl... DisGeNET Detail
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CXCR1, CXCR2, and MMP9 were expressed in 61.0%, 77.9%, and 75.6% of gastric cancer tissues, respecti... DisGeNET Detail
Calcium/calmodulin‑dependent protein kinase II enhances metastasis of human gastric cancer by upregu... DisGeNET Detail
Moreover, ALDH1A1 was significantly correlated with MMP-9 among 216 gastric cancer tissues (P<0.001)... DisGeNET Detail
The AKT/AR/MMP9 pathway plays an important role in GC metastasis and may be a novel therapeutic targ... DisGeNET Detail
Knockdown of EGFR reduced cell proliferation and invasion of GC with decreased expression of AKT, PC... DisGeNET Detail
Additionally, CEACAM6 elevated matrix metalloproteinase-9 (MMP-9) activity in GC, and anti-MMP-9 ant... DisGeNET Detail
Fz2 shRNA suppressed cell proliferation and motility of MKN45 and MKN74 cells, and downregulated cyc... DisGeNET Detail
The HER-2 positive SGC-7901 secreted more transforming growth factor beta 1 (TGF-β1) and resultantly... DisGeNET Detail
Overexpression of SMYD3 and matrix metalloproteinase-9 are associated with poor prognosis of patient... DisGeNET Detail
MMP-9 is increased in the pathogenesis of gastric cancer by the mediation of HER2. DisGeNET Detail
Activation of matrix metalloproteinase-9 (MMP-9) by neurotensin promotes cell invasion and migration... DisGeNET Detail
WISP-2 suppressed GC cell metastasis through reversing EMT and suppressing the expression and activi... DisGeNET Detail
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The expression of PRRs (Toll-like receptors and melanoma differentiation-associated gene 5) was indu... DisGeNET Detail
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Deficiency of the protein-tyrosine phosphatase DEP-1/PTPRJ promotes matrix metalloproteinase-9 expre... DisGeNET Detail
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MMP-9 expression is increased in B lymphocytes during multiple sclerosis exacerbation and is regulat... DisGeNET Detail
We could not detect an association of MMP9 SNPs with MS on a genome-wide significance level by SNP g... DisGeNET Detail
Previous studies show altered activities of matrix metalloproteinase (MMP)-2 and MMP-9 in serum and ... DisGeNET Detail
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MMP2 gene-735 C/T and MMP9 gene -1562 C/T polymorphisms in JAK2V617F positive myeloproliferative dis... DisGeNET Detail
Serum MMP-9 and CRP levels were significantly higher in the ACS group compared with controls (48.55 ... DisGeNET Detail
Overexpression of MMP-9 and its inhibitors in blood mononuclear cells after myocardial infarction--i... DisGeNET Detail
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TNCL increased the expression of several oncogenes, including MMP9, anaplastic lymphoma kinase (ALK)... DisGeNET Detail
Matrix metalloproteinase-9 (MMP-9) plays an important role in the invasion and metastasis of cancer ... DisGeNET Detail
Orphan nuclear receptor Nur77 promotes colorectal cancer invasion and metastasis by regulating MMP-9... DisGeNET Detail
SEMA4b inhibits MMP9 to prevent metastasis of non-small cell lung cancer. DisGeNET Detail
Lastly, the clinical relevance of MMP-9 overexpression is strongly supported by its significant asso... DisGeNET Detail
The spread and metastases of ATL as well as other tumors has been associated with matrix metalloprot... DisGeNET Detail
In the current study, we detected significant higher levels of placental growth factor (PLGF) and ma... DisGeNET Detail
Matrix metalloproteinase-9 (MMP-9) plays a key role in cancer invasion and metastasis by degrading t... DisGeNET Detail
As matrix metalloproteinase-9 (MMP-9) plays a critical role in tumor metastasis, we analyzed its exp... DisGeNET Detail
MMP-9-delivering TANs were also required for development of metastasis-supporting intratumoral vascu... DisGeNET Detail
Moreover, HOTAIR regulated the expression of vascular endothelial growth factor, matrix metalloprote... DisGeNET Detail
Moreover, patients that had NSCLC with metastasis had significantly higher levels of VEGF-B and MMP9... DisGeNET Detail
We found that PLGF and MMP9 levels strongly correlated in OSCC in the patients, both increased in th... DisGeNET Detail
Our experimental results suggest that HCS has some anti-metastasis potential to suppress the growth ... DisGeNET Detail
Taken together, our findings suggest that radixin is involved in GBM cell migration and invasion, an... DisGeNET Detail
Neutrophil gelatinase-associated lipocalin (NGAL) and matrix metalloproteinase-9 (MMP-9) are protein... DisGeNET Detail
However, the exact roles of SMYD3 and MMP-9 in the metastasis and prognosis of gastric cancer (GC) r... DisGeNET Detail
GOLPH3 overexpression is closely correlated with poor prognosis in human non-small cell lung cancer ... DisGeNET Detail
Matrix metalloproteinase-9 (MMP-9) plays a central role in the invasion and metastasis of various ty... DisGeNET Detail
MiR-129 regulates MMP9 to control metastasis of non-small cell lung cancer. DisGeNET Detail
Our findings suggested that HEY1 augmented the metastasis of osteosarcoma via upregulation of MMP9 e... DisGeNET Detail
Testes-specific protease 50 promotes cell invasion and metastasis by increasing NF-kappaB-dependent ... DisGeNET Detail
The results suggested that CMCS could significantly inhibit tumor cell migration in vitro, and reduc... DisGeNET Detail
The present study demonstrated that GRP78 plays important roles in invasion and metastasis of ESCC, ... DisGeNET Detail
BAG3 (p=0.013), TAP1 (p=0.014), BNIP3 (p<0.001) and MMP9 (p=0.036) were overexpressed in primary tum... DisGeNET Detail
WISP-2 suppressed GC cell metastasis through reversing EMT and suppressing the expression and activi... DisGeNET Detail
Multidimensional reduction analysis revealed LXR-β (rs3546355 G &gt; A, rs2695121 T &gt; C), MMP-2 (... DisGeNET Detail
Multidimensional reduction analysis revealed LXR-β (rs3546355 G &gt; A, rs2695121 T &gt; C), MMP-2 (... DisGeNET Detail
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Gain- and loss-of-function studies indicated that secretory ITLN1 facilitated the NDRG2 expression, ... DisGeNET Detail
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Previous studies show altered activities of matrix metalloproteinase (MMP)-2 and MMP-9 in serum and ... DisGeNET Detail
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Here we investigated the impacts of MMP-2 -1575G/A and MMP-9 -1562 C/T gene polymorphisms on disease... DisGeNET Detail
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Comparing to OA, aseptic loosening of TKA is associated with upregulated expression of CHIT1, IL-8 a... DisGeNET Detail
Then we demonstrated that SPON1 was significantly up-regulated in 72 osteosarcoma specimens compared... DisGeNET Detail
Knockdown of GAL1 suppressed cell proliferative activities and invasive potential and induced apopto... DisGeNET Detail
Overexpression of RASSF5 markedly suppressed cell proliferation and invasion, and induced cell apopt... DisGeNET Detail
We then examined the effect of HN.49 on the enzyme activity of MMP9 and the migration activity of os... DisGeNET Detail
Thus, miR-143, EGFR, and MMP9 are therapeutic targets for inhibiting OS invasion. DisGeNET Detail
ERK5 silencing inhibits invasion of human osteosarcoma cell via modulating the Slug/MMP-9 pathway. DisGeNET Detail
Our findings suggested that HEY1 augmented the metastasis of osteosarcoma via upregulation of MMP9 e... DisGeNET Detail
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The results demonstrated that siRNA-mediated knockdown of MMP-9 in the human ovarian cancer cell lin... DisGeNET Detail
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The interactions of NF-κB, MMP-9, and MICA play an important role in the development of pituitary ad... DisGeNET Detail
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Consequently this study supported that CC genotype of MMP9 gene -1562 C/T polymorphism may be relate... DisGeNET Detail
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Matrix metalloproteinase-9 and tissue inhibitor of matrix metalloproteinase-2: Prognostic biological... DisGeNET Detail
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In addition, a reverse correlation between miR-204 and CyclinD2 or MMP-9 expression was noted in ret... DisGeNET Detail
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Association between the MMP-9-1562 C>T polymorphism and the risk of stroke: a meta-analysis. DisGeNET Detail
Matrix metalloproteinase-9 (MMP-9, Gelantinase B) has been shown to relate to stroke and the develop... DisGeNET Detail
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Association of Functional Polymorphisms in Matrix Metalloproteinase-9 and Glutathione S-Transferase ... DisGeNET Detail
A statistically significant difference in genotype and allele frequencies was found between the TMD ... DisGeNET Detail
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To our knowledge, this is the first investigation of associations between the -735 C/T and -1562 C/T... DisGeNET Detail
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The rates of positive immunostaining for COX-2, MMP-9 and VEGF in PTC tumours were significantly hig... DisGeNET Detail
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The association between MMP-9 gene polymorphisms and HCC patients with hepatitis C and B viruses (HC... DisGeNET Detail
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Furthermore, exogenous miR-1224-5p expression was shown to down-regulate CREB1, as well as its downs... DisGeNET Detail
The results also demonstrated that downregulation of MMP-9 led to cell apoptosis in SKOV3 cells, inh... DisGeNET Detail
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Our findings indicate that overexpression of MMP-9 and TIMPs in blood mononuclear cells and elevated... DisGeNET Detail
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Neutrophil gelatinase-associated lipocalin (NGAL) and matrix metalloproteinase-9 (MMP-9) prognostic ... DisGeNET Detail
We found that the levels of PLGF in TE-1 cells positively affected the levels of MMP9, while the lev... DisGeNET Detail
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In addition, knockdown of MMP9 resulted in inhibition of cell migration and invasion in vitro and lu... DisGeNET Detail
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Serum MMP-9 and CRP levels were significantly higher in the ACS group compared with controls (48.55 ... DisGeNET Detail
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There was a significant upregulation of the mRNA expression of matrix metalloproteinase-2 (MMP2) and... DisGeNET Detail
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Importantly, high levels of TNF-α and RhoC-induced MMP9 were significantly correlated with brain met... DisGeNET Detail
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Silencing of Gli1 alone without external stimulus had no effect on EMT but inhibited transforming gr... DisGeNET Detail
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Combined immunohistochemical evaluation of the levels of COX-2, MMP-9 and VEGF in PTC might be a use... DisGeNET Detail
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Finally, the possible regulatory effect of fibronectin peptides in liver fibrosis was further suppor... DisGeNET Detail
Mutant MMP-9 and HGF gene transfer enhance resolution of CCl4-induced liver fibrosis in rats: role o... DisGeNET Detail
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DLK1 promotes lung cancer cell invasion through upregulation of MMP9 expression depending on Notch s... DisGeNET Detail
In conclusion, we report that the shRNA-mediated knockdown of RhoGDI2 induces the invasion and migra... DisGeNET Detail
For example, matrix metalloproteinase 9 (MMP9) is overexpressed in tumors, is known to enhance the m... DisGeNET Detail
Matrix metalloproteinase 9 (MMP9) expression is positively correlated with lung cancer malignancy. DisGeNET Detail
Lack of association between the rs2664538 polymorphism in the MMP-9 gene and primary angle closure g... DisGeNET Detail
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MMP9 is an important regulating enzyme in ECM metabolism, and the MMP9 gene may be a candidate gene ... DisGeNET Detail
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In the mouse CaCl2-induced AAA model, deficiency of myeloid TM, but not vascular smooth muscle cell ... DisGeNET Detail
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Furthermore, the down-regulation of NDRG1 in gastric cancer metastatic progression was correlated to... DisGeNET Detail
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Restoration of RUNX3 expression significantly inhibits ESCC cells migration, invasion, and tumorigen... DisGeNET Detail
In conclusion, this study showed that the MMP2 -1306 TT and MMP9 -1562 CC genotypes were associated ... DisGeNET Detail
The present study demonstrated that GRP78 plays important roles in invasion and metastasis of ESCC, ... DisGeNET Detail
As a consequence, activation of MMP-9 and the rearrangement of F-actin throw light on the mechanisms... DisGeNET Detail
MMP13 expression was highest in Barrett's metaplasia, whereas MMP9 was highest in the esophageal ade... DisGeNET Detail
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TNF-α enhanced migration and invasion of ccRCC cells together with down-regulation of E-cadherin exp... DisGeNET Detail
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The prevalence of moderate to intense MMP-9 staining was 9% in normal cervical smears, 12% in cervic... DisGeNET Detail
Matrix metalloproteinase 9 and transglutaminase 2 expression at the ocular surface in patients with ... DisGeNET Detail
In our experiments, elevated expression of MMP9 in dry eye subjects correlated with the ability of a... DisGeNET Detail
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An intragroup analysis of the time factor for the microemboli groups showed significantly more MMP-9... DisGeNET Detail
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MMP-9 expression increases according to the grade of squamous intraepithelial lesion in cervical sme... DisGeNET Detail
The prevalence of moderate to intense MMP-9 staining was 9% in normal cervical smears, 12% in cervic... DisGeNET Detail
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PTX3 expression, and MMP-9 and CRP levels in the SAP subgroup, were not significantly different from... DisGeNET Detail
All these findings suggest that ACS patients have remarkably higher MMP-9, 1TIMP-1, MMP- 9/TIMP-1, I... DisGeNET Detail
Serum MMP-9 and CRP levels were significantly higher in the ACS group compared with controls (48.55 ... DisGeNET Detail
We found that interleukin (IL) 6 (IL-6), IL-1β, monocyte chemoattractant protein-1 (CCL2) macrophage... DisGeNET Detail
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Association of the polymorphisms of MMP-9 and TIMP-3 genes with thoracic aortic dissection in Chines... DisGeNET Detail
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BTG1 expression decreased in hepatocellular cancer and correlated significantly with lymph node meta... DisGeNET Detail
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Silencing of Gli1 alone without external stimulus had no effect on EMT but inhibited transforming gr... DisGeNET Detail
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miR-34a inhibits migration and invasion of tongue squamous cell carcinoma via targeting MMP9 and MMP... DisGeNET Detail
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Our data showed that knockdown of SPAG9 in prostate cancer cell lines inhibited cell motility and in... DisGeNET Detail
Overexpression of GRP78 upregulated the expression of MMP-9 and VEGFR2 in PC-3 and HUVECs. DisGeNET Detail
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In this study, the possible association between MMP-9 and MMP-2 functional promoter polymorphism, st... DisGeNET Detail
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Autosomal dominant (AD) MANDP has been described as more severe, and has been associated with domina... DisGeNET Detail
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The relationships between the immunoexpression of KAI1, MMP-2, MMP-9 and steroid receptors expressio... DisGeNET Detail
The expression of six genes was significantly different in primary tumors compared with their matche... DisGeNET Detail
Our experimental results suggest that HCS has some anti-metastasis potential to suppress the growth ... DisGeNET Detail
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Functional polymorphisms in the promoter region of MMP-2 and MMP-9 and susceptibility to obstructive... DisGeNET Detail
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The MMP-9 -1562 C/T polymorphism in the presence of metabolic syndrome increases the risk of clinica... DisGeNET Detail
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We found that the levels of PLGF in TE-1 cells positively affected the levels of MMP9, while the lev... DisGeNET Detail
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Moreover, the suppressive role of miR-199a in cell migration in cSCC cells was also associated with ... DisGeNET Detail
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Knockdown of GAL1 suppressed cell proliferative activities and invasive potential and induced apopto... DisGeNET Detail
Overexpression of RASSF5 markedly suppressed cell proliferation and invasion, and induced cell apopt... DisGeNET Detail
We then examined the effect of HN.49 on the enzyme activity of MMP9 and the migration activity of os... DisGeNET Detail
Thus, miR-143, EGFR, and MMP9 are therapeutic targets for inhibiting OS invasion. DisGeNET Detail
ERK5 silencing inhibits invasion of human osteosarcoma cell via modulating the Slug/MMP-9 pathway. DisGeNET Detail
Our findings suggested that HEY1 augmented the metastasis of osteosarcoma via upregulation of MMP9 e... DisGeNET Detail
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In summary, AR overexpression induced by AKT phosphorylation upregulated MMP9 by binding to its prom... DisGeNET Detail
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Although results thus far are inconsistent, meta-analysis has demonstrated that MMP-3 Glu45Lys and M... DisGeNET Detail
Our data showed that knockdown of SPAG9 in prostate cancer cell lines inhibited cell motility and in... DisGeNET Detail
Overexpression of GRP78 upregulated the expression of MMP-9 and VEGFR2 in PC-3 and HUVECs. DisGeNET Detail
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Downregulation of matrix metalloproteinase 9 by small interfering RNA inhibits the tumor growth of o... DisGeNET Detail
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In the present study, we demonstrate that green tea polyphenols (GTP) and its major constituent, epi... DisGeNET Detail
In addition, CXCR7 regulated breast cancer metastasis by enhancing expression of metalloproteinases ... DisGeNET Detail
Delphinidin suppresses PMA-induced MMP-9 expression by blocking the NF-κB activation through MAPK si... DisGeNET Detail
MMP-9 expression varies according to molecular subtypes of breast cancer. DisGeNET Detail
The results suggested that the anticancer properties of ginsenoside Rg1 may derive from its ability ... DisGeNET Detail
Celastrol induces the apoptosis of breast cancer cells and inhibits their invasion via downregulatio... DisGeNET Detail
These results indicate that Ethyl gallate suppresses proliferation and invasion in human breast canc... DisGeNET Detail
Protein arginine methyltransferase 7 promotes breast cancer cell invasion through the induction of M... DisGeNET Detail
Mechanistically, eIF4E silencing or blockade reduced the invasiveness and metastatic capability of b... DisGeNET Detail
Taken together, our findings indicate that the MMP-9 inhibitory activity of glaucine and its abiliti... DisGeNET Detail
Matrix metalloproteinase-9 -1562T allele and its combination with MMP-2 -735 C allele are risk facto... DisGeNET Detail
Taken together, this work identified the TSP50 activation of MMP9 as a novel signaling mechanism und... DisGeNET Detail
Association between four MMP-9 polymorphisms and breast cancer risk: a meta-analysis. DisGeNET Detail
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DLK1 promotes lung cancer cell invasion through upregulation of MMP9 expression depending on Notch s... DisGeNET Detail
In conclusion, we report that the shRNA-mediated knockdown of RhoGDI2 induces the invasion and migra... DisGeNET Detail
These results suggested that PFIO could suppress the invasion and migration of human lung carcinoma ... DisGeNET Detail
For example, matrix metalloproteinase 9 (MMP9) is overexpressed in tumors, is known to enhance the m... DisGeNET Detail
Matrix metalloproteinase 9 (MMP9) expression is positively correlated with lung cancer malignancy. DisGeNET Detail
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miR-34a plays an important role in lymph node metastases of TSCC through targeting MMP9 and MMP14 an... DisGeNET Detail
In addition, the expression of SMYD3 was correlated with size of primary tumor and lymph node metast... DisGeNET Detail
Gli1 expression was associated positively with tumor T (P = .025) and Union for International Cancer... DisGeNET Detail
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In this study, we demonstrated that β6 integrin induced the expression of MMP-3/MMP-9 and the invasi... DisGeNET Detail
CXCR1, CXCR2, and MMP9 were expressed in 61.0%, 77.9%, and 75.6% of gastric cancer tissues, respecti... DisGeNET Detail
Calcium/calmodulin‑dependent protein kinase II enhances metastasis of human gastric cancer by upregu... DisGeNET Detail
Moreover, ALDH1A1 was significantly correlated with MMP-9 among 216 gastric cancer tissues (P<0.001)... DisGeNET Detail
The AKT/AR/MMP9 pathway plays an important role in GC metastasis and may be a novel therapeutic targ... DisGeNET Detail
Knockdown of EGFR reduced cell proliferation and invasion of GC with decreased expression of AKT, PC... DisGeNET Detail
Additionally, CEACAM6 elevated matrix metalloproteinase-9 (MMP-9) activity in GC, and anti-MMP-9 ant... DisGeNET Detail
Fz2 shRNA suppressed cell proliferation and motility of MKN45 and MKN74 cells, and downregulated cyc... DisGeNET Detail
The HER-2 positive SGC-7901 secreted more transforming growth factor beta 1 (TGF-β1) and resultantly... DisGeNET Detail
Overexpression of SMYD3 and matrix metalloproteinase-9 are associated with poor prognosis of patient... DisGeNET Detail
MMP-9 is increased in the pathogenesis of gastric cancer by the mediation of HER2. DisGeNET Detail
Activation of matrix metalloproteinase-9 (MMP-9) by neurotensin promotes cell invasion and migration... DisGeNET Detail
WISP-2 suppressed GC cell metastasis through reversing EMT and suppressing the expression and activi... DisGeNET Detail
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Gain- and loss-of-function studies indicated that secretory ITLN1 facilitated the NDRG2 expression, ... DisGeNET Detail
Association of the polymorphisms of MMP-9 and TIMP-3 genes with thoracic aortic dissection in Chines... DisGeNET Detail
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In diabetic patients, the upregulation of urinary MMP-9 concentrations occurred earlier than the ons... DisGeNET Detail
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Here, we describe the method to generate Ins2+/-/Mmp9-/- (DKO) mice to determine whether the abrogat... DisGeNET Detail
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Our data suggest that MMP-9 deletion improves mitochondrial function post-MI. DisGeNET Detail
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Pentraxin 3, long expression in mononuclear cells of patients with acute coronary syndrome: Correlat... DisGeNET Detail
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Berberine inhibits Chlamydia pneumoniae infection-induced vascular smooth muscle cell migration thro... DisGeNET Detail
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The results demonstrated that siRNA-mediated knockdown of MMP-9 in the human ovarian cancer cell lin... DisGeNET Detail
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MMP2 gene-735 C/T and MMP9 gene -1562 C/T polymorphisms in JAK2V617F positive myeloproliferative dis... DisGeNET Detail
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Thus, the expression of MMP-9 in cervical smears increases according to the grade of cervical lesion... DisGeNET Detail
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Ovarian serous carcinomas (n=112) and solid metastases (n=63; total=175) were analyzed for mRNA expr... DisGeNET Detail
Mechanistically, silencing of SENP1 results in downregulation of MMP-9, which is pivotal for PDAC ce... DisGeNET Detail
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Serum levels of MMP1, MMP2, and MMP9 were analyzed in patients with oropharyngeal, laryngeal, and hy... DisGeNET Detail
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Activated Mmp9 degrades extracellular matrix (ECM) and increases matrix turnover causing cardiac fib... DisGeNET Detail
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MMP9 also enhances PKD2-mediated tumor angiogenesis releasing extracellular matrix-bound VEGF-A. DisGeNET Detail
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Interestingly, Nur77-mediated CRC invasion via MMP-9 and E-cadherin could be mimicked by some metast... DisGeNET Detail
At last, in the tumor samples from patients with locally advanced colorectal cancer with routine pos... DisGeNET Detail
Our results suggest that DIM can influence the cell migratory and invasive properties of human color... DisGeNET Detail
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A significant decline of MMP-9 and MMP-2 secretion in cultured U87MG was detected after incubation w... DisGeNET Detail
Overexpression and knockdown of PODX respectively reversed and enhanced the inhibitory effects of An... DisGeNET Detail
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In a previous study, penta-O-galloyl-β-D-glucose (PGG) suppressed androgen-independent prostate canc... DisGeNET Detail
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Deficiency of the protein-tyrosine phosphatase DEP-1/PTPRJ promotes matrix metalloproteinase-9 expre... DisGeNET Detail
MMPs and their inhibitors, tissue inhibitors of MMPs (TIMPs), have been implicated in the pathogenes... DisGeNET Detail
A statistically significant difference in genotype and allele frequencies was found between the TMD ... DisGeNET Detail
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By IHC, higher expression of MMP-2 and MMP-9 in PSP patients was identified in alveolar macrophages ... DisGeNET Detail
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The relationships between the immunoexpression of KAI1, MMP-2, MMP-9 and steroid receptors expressio... DisGeNET Detail
The MMP-9 -1562 C/T polymorphism in the presence of metabolic syndrome increases the risk of clinica... DisGeNET Detail
Moreover, COL14A1 and MMP9 DNA methylation levels were associated with CAD, age of onset of CAD or C... DisGeNET Detail
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Compared with a 1-time measurement of 8 healthy participants, among 16 symptomatic patients, the mea... DisGeNET Detail
FOXA2 suppresses the metastasis of hepatocellular carcinoma partially through matrix metalloproteina... DisGeNET Detail
Metformin was also found to significantly inhibit the expression and secretion of MMP-9 and uPA in H... DisGeNET Detail
People with significantly elevated serum levels of MMP-9 are at risk of developing HCC. DisGeNET Detail
Moreover, NS3 enhanced hepatoma cell invasion and migration through MMP-9 and COX-2. DisGeNET Detail
Matrix metalloproteinase (MMP)2 and MMP9 activity was involved partly in the GEP-regulated MICA shed... DisGeNET Detail
In this study, we report that MUC1 overexpression enhanced the levels of phosphorylated Smad3 linker... DisGeNET Detail
Hepatoprotective and anti-tumor effects of targeting MMP-9 in hepatocellular carcinoma and its relat... DisGeNET Detail
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IL-6, IL-8, MMP-2, MMP-9 are overexpressed in Fanconi anemia cells through a NF-κB/TNF-α dependent m... DisGeNET Detail
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We analyzed 57 prolactinoma patients classified as having invasive and noninvasive adenomas for MMP-... DisGeNET Detail
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Overexpression of MMP-9 in lung tissue and its interaction with CAP1 is likely to play a major role ... DisGeNET Detail
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EGF, MMP2, and MMP9 expression in ameloblastoma biopsies and in the AME-HPV cell line was analyzed b... DisGeNET Detail
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It is likely that the aberrantly accelerated MMP-9 proteolysis during neurogenesis is a biochemical ... DisGeNET Detail
Matrix metalloproteinase-9 deficiency attenuates diabetic nephropathy by modulation of podocyte func... DisGeNET Detail
Pharmacological inhibition of 5-LO-attenuated aneurysm formation in both aortic elastase perfused wi... DisGeNET Detail
Since the clinical manifestations in Behçet disease (BD) include aneurysm formation among major symp... DisGeNET Detail
Matrix metalloproteinase-9 (MMP-9, Gelantinase B) has been shown to relate to stroke and the develop... DisGeNET Detail
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After the monolayer adherent ECs reached confluence, they were tested with endothelial specific mark... DisGeNET Detail
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The synthesis and secretion of MMP-9 can be stimulated by a variety of stimuli, including cytokines ... DisGeNET Detail
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Prolonged Treatment with Inhaled Corticosteroids does not Normalize High Activity of Matrix Metallop... DisGeNET Detail
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MMP activity was further validated in Barrett's esophagus and esophageal adenocarcinoma patient biop... DisGeNET Detail
Association of MMP-9 gene polymorphisms with Behçet's disease risk. DisGeNET Detail
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In the present study, we demonstrate that green tea polyphenols (GTP) and its major constituent, epi... DisGeNET Detail
In addition, CXCR7 regulated breast cancer metastasis by enhancing expression of metalloproteinases ... DisGeNET Detail
Delphinidin suppresses PMA-induced MMP-9 expression by blocking the NF-κB activation through MAPK si... DisGeNET Detail
MMP-9 expression varies according to molecular subtypes of breast cancer. DisGeNET Detail
The results suggested that the anticancer properties of ginsenoside Rg1 may derive from its ability ... DisGeNET Detail
Celastrol induces the apoptosis of breast cancer cells and inhibits their invasion via downregulatio... DisGeNET Detail
These results indicate that Ethyl gallate suppresses proliferation and invasion in human breast canc... DisGeNET Detail
Protein arginine methyltransferase 7 promotes breast cancer cell invasion through the induction of M... DisGeNET Detail
Mechanistically, eIF4E silencing or blockade reduced the invasiveness and metastatic capability of b... DisGeNET Detail
Taken together, our findings indicate that the MMP-9 inhibitory activity of glaucine and its abiliti... DisGeNET Detail
Matrix metalloproteinase-9 -1562T allele and its combination with MMP-2 -735 C allele are risk facto... DisGeNET Detail
Taken together, this work identified the TSP50 activation of MMP9 as a novel signaling mechanism und... DisGeNET Detail
Association between four MMP-9 polymorphisms and breast cancer risk: a meta-analysis. DisGeNET Detail
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In this study, we demonstrated that β6 integrin induced the expression of MMP-3/MMP-9 and the invasi... DisGeNET Detail
The relationships between the immunoexpression of KAI1, MMP-2, MMP-9 and steroid receptors expressio... DisGeNET Detail
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Expression of high mobility group box - B1 (HMGB-1) and matrix metalloproteinase-9 (MMP-9) in non-sm... DisGeNET Detail
SEMA4b inhibits MMP9 to prevent metastasis of non-small cell lung cancer. DisGeNET Detail
Correlations of lysyl oxidase with MMP2/MMP9 expression and its prognostic value in non-small cell l... DisGeNET Detail
Thus, our data highlight a coordinating relationship between VEGF-B and MMP9 in the regulation of ne... DisGeNET Detail
Knockdown of GOLPH3 significantly suppressed the migratory and invasive ability of NSCLC cell lines ... DisGeNET Detail
MiR-129 regulates MMP9 to control metastasis of non-small cell lung cancer. DisGeNET Detail
We have recently shown that Semaphorin 4B (SEMA4B) inhibits the invasion of non-small cell lung canc... DisGeNET Detail
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Overlapped Transcript Coordinates

Gene Transcript ID Exon Number Chromosome Start Stop Type Amino Mutation Transcript Position Links

Overlapped Transcript

Gene Transcript ID Chromosome Start Stop Links
Gene
-
dbSNP
rs2664538 dbSNP
Genome
hg38
Position
chr20:46,008,908-46,016,561
Variant Type
snv
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