keratoconjunctivitis sicca
Information
- Disease name
- keratoconjunctivitis sicca
- Disease ID
- DOID:12895
- Description
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
| Genes | Mutation | Description | Source | Links |
|---|
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT05618730 | Active, not recruiting | Phase 1 | Safety, Tolerability, Plug Retention and Preliminary Efficacy of Tacrolimus-loaded Punctal Plug in Patients With Moderate to Severe Dry Eye Disease - Cohort B | September 29, 2022 | December 30, 2023 |
| NCT00025818 | Completed | Phase 3 | Six Month Clinical Research Study for Patients With Moderate or Severe Dry Eye Syndrome | May 2001 | March 2003 |
| NCT00037661 | Completed | Phase 3 | Study of INS365 Ophthalmic Solution in a Controlled Adverse Environment in Patients With Dry Eye | April 2002 | March 2003 |
| NCT00128245 | Completed | Phase 2 | Safety and Efficacy of Pimecrolimus Ophthalmic Suspension in Patients With Moderate to Severe Keratoconjunctivitis Sicca | September 2004 | December 2006 |
| NCT00201955 | Completed | Phase 3 | Study of Rebamipide Eye Drops to Treat Dry Eye | May 2004 | July 2006 |
| NCT00201981 | Completed | Phase 3 | Study of Rebamipide Eye Drops to Treat Dry Eye | May 2004 | February 2007 |
| NCT00345241 | Completed | N/A | Effects of Systane Versus Saline in Maintaining Tear Film Stability at Determined Time Points | January 2006 | December 2006 |
| NCT00349466 | Completed | Phase 2 | Safety and Efficacy Study of CF101 to Treat Keratoconjunctivitis Sicca | January 2007 | May 2009 |
| NCT00407043 | Completed | Phase 4 | Multicenter, Randomized, Controlled Study of the Effect of Lotemax on Initiation of Dry Eye Treatment With Restasis | November 2006 | September 2007 |
| NCT00426543 | Completed | Phase 2 | Effect of B-cell Depletion in Patients With Primary Sjögren's Syndrome | January 2007 | August 2010 |
| NCT00554879 | Completed | N/A | Acupuncture Treatment of Dry Eye | November 2007 | February 2011 |
| NCT00681265 | Completed | N/A | Tear Film Break-up Time After Instillation of Artificial Tears | June 2008 | August 2008 |
| NCT00717418 | Completed | Efficacy Study of Cyclosporine Ophthalmic Emulsion in Patients With Dry Eye Disease | September 2004 | August 2008 | |
| NCT00788229 | Completed | Phase 2 | Efficacy and Safety Study of ATs in Patients With Dry Eye Syndrome | November 2008 | August 2009 |
| NCT00848198 | Completed | TearLab Core Validation Study to Establish Referent Values for Dry Eye Disease | February 2009 | March 2011 | |
| NCT00851734 | Completed | Phase 1 | A Dose-Escalation Study to Assess the Safety and Tolerability of LX214 Ophthalmic Solution in Healthy Volunteers, Followed by an Open-Label Evaluation of LX214 in Patients With Keratoconjunctivitis Sicca (KCS) | February 2009 | April 2009 |
| NCT00883649 | Completed | N/A | Efficacy and Safety Study of Nutritional Supplements for Treatments of Dry Eye | September 2008 | |
| NCT00987727 | Completed | Phase 4 | Safety and Efficacy of Carboxymethylcellulose for Ocular Surface Integrity in Symptomatic Dry Eye | November 2009 | September 2010 |
| NCT01027013 | Completed | Phase 2 | Safety and Efficacy Study of Rebamipide 2% Ophthalmic Suspension in Patients With Dry Eye | December 2009 | November 2010 |
| NCT01057147 | Completed | Phase 2 | Safety and Efficacy Study of Rebamipide 2% Ophthalmic Suspension in Subjects With Dry Eye - Effects on Central Cornea | February 2010 | February 2011 |
| NCT01102257 | Completed | Phase 2/Phase 3 | Dry Eye Assessment and Management: Feasibility Study | January 2010 | March 2011 |
| NCT02970799 | Completed | N/A | Tear Production by Nasal Neurostimulation Compared to Active Control | August 31, 2016 | October 31, 2016 |
| NCT03706443 | Completed | N/A | Tear Lipid Layer Thickness Changes With Use of Emollient and Non-Emollient Eye Drops | December 5, 2018 | February 28, 2019 |
| NCT03753893 | Completed | Ocular Manifestations in Rheumatic Diseases | May 1, 2013 | November 1, 2021 | |
| NCT03925727 | Completed | Phase 3 | Tavilermide Ophthalmic Solution for the Treatment of Dry Eye | March 28, 2019 | June 11, 2020 |
| NCT04147650 | Completed | Phase 2/Phase 3 | Dose Ranging Study to Assess the Efficacy and Safety of Voclosporin Ophthalmic Solution in Subjects With Dry Eye Syndrome | October 14, 2019 | October 8, 2020 |
| NCT04421300 | Completed | N/A | A Randomized Study of Smile Exercise for Dry Eye | July 2, 2020 | April 2, 2021 |
| NCT04493658 | Completed | Differential Diagnosis of Sjögren's Versus Non-Sjögren's Dry Eye | January 11, 2021 | October 3, 2022 | |
| NCT04649177 | Completed | N/A | Pilot Study to Investigate the Feasibility, Reliability and Efficacy of Utilizing OCT to Automate PROSE Fitting | December 15, 2020 | March 23, 2022 |
| NCT05918406 | Completed | Phase 4 | Phase 4 Study Evaluating the Safety of the Nasal Guide With Tyrvaya | June 14, 2023 | August 18, 2023 |
| NCT01235234 | Completed | Phase 3 | Trial of CF101 to Treat Patients With Dry Eye Disease | July 2011 | December 2013 |
| NCT01421498 | Completed | Phase 3 | Safety and Efficacy Study of SAR 1118 to Treat Dry Eye Conducted in a Controlled Adverse Environment (CAE) (OPUS-1) | August 29, 2011 | April 28, 2012 |
| NCT01547936 | Completed | Effect of Controlled Adverse Environment (CAE) on Tear Film Stability | February 2012 | February 2012 | |
| NCT01733992 | Completed | Phase 1 | A Safety, Tolerability and Pharmacokinetics Study of R932348 Eye Drops in Patients With Dry Eye Disease | November 2012 | February 2013 |
| NCT01797822 | Completed | Phase 4 | Effects of Dry Eye Treatments on the Ocular Surface | February 2013 | December 2015 |
| NCT01817582 | Completed | Phase 2 | Lotemax® Gel 0.5% and Restasis 0.05% in Participants With Mild or Moderate Keratoconjunctivitis Sicca (Dry Eye Disease) | May 17, 2013 | January 10, 2014 |
| NCT01900249 | Completed | Phase 2 | To Assess the Safety and Efficacy of R932348 Ophthalmic Solutions in Patients With Keratoconjunctivitis Sicca | July 2013 | July 2014 |
| NCT02066896 | Completed | N/A | Laser Therapy to Treat the Dry Mouth of Sjogren's Syndrome | May 2014 | August 2016 |
| NCT02117687 | Completed | Phase 4 | A Safety and Efficacy Study of OPTIVE FUSION™ With VISMED® Multi for the Management of Dry Eye | May 14, 2014 | March 17, 2015 |
| NCT02121301 | Completed | Phase 2 | A Clinical Study to Assess the Safety and Efficacy of an Ophthalmic Solution (SkQ1) in the Treatment of Dry Eye Syndrome (DES) | April 2014 | June 2014 |
| NCT02139033 | Completed | Phase 4 | A Phase 4 Study Investigating the Efficacy of Retaine™ in Managing Signs and Symptoms Associated With Dry Eye Syndrome | May 2014 | May 2014 |
| NCT02188160 | Completed | Phase 2 | Safety and Efficacy of KPI-121 in Subjects With Dry Eye Disease | June 2014 | March 2015 |
| NCT02254265 | Completed | Phase 2/Phase 3 | Phase 2/3 Dose-Ranging Study of the Safety and Efficacy of OTX-101 in the Treatment of Keratoconjunctivitis Sicca | September 2014 | May 2015 |
| NCT02526290 | Completed | N/A | Six Month Study to Evaluate the Safety and Effectiveness of the Intranasal Lacrimal Neurostimulator | August 31, 2015 | April 30, 2016 |
| NCT02634853 | Completed | Phase 3 | A Safety and Efficacy Study of Tavilermide (MIM-D3) Ophthalmic Solution for the Treatment of Dry Eye | December 2015 | March 2017 |
| NCT02665234 | Completed | Phase 3 | A Safety and Efficacy Study of Tavilermide (MIM-D3) Ophthalmic Solution for the Treatment of Dry Eye Disease | January 2016 | March 2017 |
| NCT02680158 | Completed | N/A | A Study to Evaluate the Safety and Effectiveness of Oculeve Intranasal Lacrimal Neurostimulator in Participants With Dry Eye Syndrome | January 31, 2016 | March 31, 2016 |
| NCT02688556 | Completed | Phase 3 | Phase 3 Study of OTX-101 in the Treatment of Keratoconjunctivitis Sicca | February 2016 | December 2016 |
| NCT02798289 | Completed | N/A | Acute Tear Production Following Single Use of the Oculeve Intranasal Neurostimulator | June 2016 | August 2016 |
| NCT02813265 | Completed | Phase 3 | Safety and Efficacy of KPI-121 in Subjects With Dry Eye Disease | June 2016 | October 2017 |
| NCT02819284 | Completed | Phase 3 | Safety and Efficacy of KPI-121 Compared to Placebo in Subjects With Dry Eye Disease | June 2016 | September 2017 |
| NCT02845674 | Completed | Phase 3 | An Open-Label Extension of a Phase 3 Study of OTX-101 in the Treatment of Keratoconjunctivitis Sicca | July 29, 2016 | August 15, 2017 |
| NCT00001731 | Completed | Phase 2 | Treatment of Dry Eye Syndrome With Cyclosporin A Eye Drops | November 1997 | October 2000 |
| NCT03953703 | Recruiting | Phase 2 | Levocarnitine for Dry Eye in Sjogren's Syndrome | November 17, 2021 | March 1, 2025 |
| NCT01213342 | Terminated | N/A | Omega-3 Fatty Acid Supplements and Dry Eye | May 2010 | July 2011 |
| NCT03436576 | Unknown status | Phase 3 | Efficacy of Two Concentrations of Autologous Serum for the Treatment of Severe Dry Eye | September 12, 2018 | November 19, 2018 |
| NCT04884217 | Unknown status | Phase 2 | Treatment of Dry Eye Disease Using Pro-ocular™ - A Proof of Concept, Safety, and Efficacy Study | May 20, 2021 | December 30, 2021 |
| NCT00411827 | Unknown status | N/A | Goblet Cell Response and Dry Eye Symptoms After PRK and LASIK | January 2008 | December 2014 |
| NCT03408015 | Withdrawn | Phase 4 | Effects of Xiidra on Closed Eye Tear Film Leukocytes in Dry Eye Disease | January 2019 | January 30, 2019 |
| NCT01226680 | Withdrawn | Phase 2 | A Study Of Tasocitinib In Dry Eye Subjects | December 1, 2010 | October 19, 2012 |
| NCT03398018 | Withdrawn | Phase 4 | Repository Corticotropin Injection in Keratoconjunctivitis Sicca | November 1, 2018 | November 1, 2018 |
- Disase is a (Disease Ontology)
- DOID:10140
- Cross Reference ID (Disease Ontology)
- GARD:8444
- Cross Reference ID (Disease Ontology)
- MESH:D007638
- Cross Reference ID (Disease Ontology)
- SNOMEDCT_US_2023_03_01:78946008
- Cross Reference ID (Disease Ontology)
- UMLS_CUI:C0022575
- Exact Synonym (Disease Ontology)
- KCS
- HPO Human Phenotype ID (Human Phenotype Ontology)
- HP:0001097
- MeSH unique ID (MeSH (Medical Subject Headings))
- D007638