cleft palate
Information
- Disease name
- cleft palate
- Disease ID
- DOID:674
- Description
- "An orofacial cleft characterized by a fissure of the soft and/or hard palate, due to faulty fusion of the two plates of the skull that form the hard palate." [url:http\://en.wikipedia.org/wiki/Cleft_lip_and_palate#Cleft_palate, url:http\://ghr.nlm.nih.gov/glossary=cleftpalate]
Disease area statistics
Chromosome band
| Gene symbol | Chromosome | Start | Stop | The number of variant |
|---|---|---|---|---|
| NEDD4L | 18 | 58,044,226 | 58,401,539 | 4 |
Annotation
| Genes | Mutation | Description | Source | Links |
|---|
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT04277273 | Completed | N/A | Characteristics of a Maxillofacial Prosthesis Consultation Within Assistance Publique - Hopitaux de Paris | November 13, 2020 | May 7, 2021 |
| NCT00097149 | Completed | N/A | Systematic Pediatric Care for Oral Clefts - South America | May 2003 | May 2006 |
| NCT00098319 | Completed | Phase 3 | Oral Cleft Prevention Trial in Brazil | January 2004 | April 2007 |
| NCT00004639 | Completed | Phase 2 | Cleft Palate Surgery and Speech Development | February 1996 | April 2007 |
| NCT00340977 | Completed | Svangerskap, Arv, Og Miljo (Pregnancy, Heredity and Environment) | September 6, 1995 | November 18, 2019 | |
| NCT00397917 | Completed | Phase 3 | Oral Cleft Prevention Program | November 2006 | July 2013 |
| NCT00423072 | Completed | Middle Ear Pressure Disregulation in Cleft Palate Patients | August 2006 | May 22, 2017 | |
| NCT00584272 | Completed | Retrospective Study on the Outcome of Cleft Palate Repair: Comparing US Surgical and Ethicon Suture Materials | March 2007 | April 2015 | |
| NCT00773994 | Completed | N/A | Pilot Study Evaluating Characteristic Closure Patterns of the Normal Velopharyngeal Portal | May 2008 | July 15, 2015 |
| NCT04616690 | Completed | Three-dimensional Cleft Lip and Palate Morphology Prior to One-stage Cleft Repair | December 7, 2020 | March 8, 2024 | |
| NCT04366674 | Completed | N/A | Mordified Restoration of Tensor Veli Palatini in Cleft Palate Repair | January 1, 2013 | June 30, 2019 |
| NCT03966482 | Completed | N/A | Semi-occluded Vocal Tract Exercise in Velopharyngeal Dysfunction in Patients With Cleft Palate | May 1, 2016 | November 28, 2017 |
| NCT00829101 | Completed | Articulation and Phonology in Children With Unilateral Cleft Lip and Palate | January 2009 | July 2014 | |
| NCT00993551 | Completed | N/A | Timing of Primary Surgery for Cleft Palate | July 2010 | March 26, 2021 |
| NCT00993993 | Completed | Relational Development in Children With Cleft Lips and Palates: Influence of the Waiting Period Prior to the First Surgical Intervention and the Parents' Psychological Perception of the Abnormality | April 27, 2010 | January 7, 2013 | |
| NCT01046591 | Completed | Sleep and Behavior in Children With Cleft Palate | December 2006 | December 2011 | |
| NCT01252264 | Completed | FaceBase Biorepository | November 2010 | July 2015 | |
| NCT01380171 | Completed | Primary Palatoplasty in Pediatric Patients - A Retrospective Review of Surgical Outcomes | February 2007 | December 2009 | |
| NCT01500109 | Completed | N/A | Efficacy of Oral Versus Intravenous Acetaminophen for Primary Pediatric Cleft Palate Repair | November 2011 | August 2014 |
| NCT01535131 | Completed | N/A | Furlow Palatoplasty With Tensor Tenopexy | February 28, 2012 | June 30, 2020 |
| NCT06229587 | Completed | N/A | Furlow With Buccinator and Velopharyngeal Function | February 1, 2024 | March 1, 2024 |
| NCT01616953 | Completed | Phase 1/Phase 2 | Cell Therapy for Craniofacial Bone Defects | August 2012 | June 2015 |
| NCT06103162 | Completed | N/A | Comparison of Different Feeding Appliances for Cleft Palate Babies | July 1, 2023 | October 16, 2023 |
| NCT01867632 | Completed | Acellular Dermal Matrix in Primary Palatoplasty | September 2012 | March 31, 2017 | |
| NCT02247193 | Completed | Phase 1/Phase 2 | Botulinum Toxin to Improve Cosmesis of Primary Cleft Lip Repair | December 2015 | January 13, 2020 |
| NCT02329509 | Completed | N/A | Evaluation of Facial Growth in Two Primary Protocols Used in the Surgical Treatment of Unilateral Cleft Lip and Palate Patients | January 2010 | September 2016 |
| NCT02350803 | Completed | Phase 2 | Does Use of Rigid Fixation After Removing Distraction Osteogenesis Device Reduce the Relapse? | February 2011 | December 2014 |
| NCT02415361 | Completed | N/A | Follow Ups of Parents With Infants With Cleft Lip and Palate | April 2015 | January 2019 |
| NCT02422056 | Completed | Phase 4 | Acid Tranexamic Effectiveness in Reducing the Intraoperative Bleeding in Palatoplasty | December 2013 | March 2015 |
| NCT02583100 | Completed | N/A | Improving Outcomes in Cleft Palate Surgery | October 2015 | September 2018 |
| NCT05405738 | Completed | Cleft Palate Technique and Maxillary Growth | May 6, 2022 | March 1, 2023 | |
| NCT02658318 | Completed | Postoperative Complications After Cleft Palate Closure in Patients With Pierre Robin Sequence: Operative Considerations | January 2011 | August 2015 | |
| NCT05286398 | Completed | N/A | Effect of Cleft Palate Repair Using Alveolar Extension Technique on Eruption and Growth | December 22, 2019 | January 16, 2022 |
| NCT02900014 | Completed | N/A | Validation of a Production Method of Stem Cell Isolated From the Nasal Cavity for an Innovative Cell Therapy of Cleft Palate | September 18, 2015 | August 4, 2023 |
| NCT05196555 | Completed | N/A | Cleft Palate With Intravelar Veloplasty Repair | August 6, 2019 | December 17, 2020 |
| NCT05166408 | Completed | N/A | Fistiulation Rate Following Primary Cleft Repair≤ | September 24, 2019 | February 5, 2021 |
| NCT03170505 | Completed | Using of Acellular Dermal Matrix in Cleft Palatal Fistula and Compare With Use of Conchal Cartolage | May 27, 2015 | May 27, 2017 | |
| NCT03412474 | Completed | Phase 2 | Suprazygomatic Block in Cleft Palate Surgery in Children | January 14, 2018 | August 31, 2018 |
| NCT04725370 | Completed | Characterization of Cleft Lip and Palate Conditions in Guatemala | October 30, 2017 | March 13, 2020 | |
| NCT04718558 | Completed | Optic Nerve Sheath Diameter Measurement in Cleft Palate Repair | October 1, 2020 | July 1, 2021 | |
| NCT03585608 | Completed | Optic Nerve Sheath Diameter in Patients Undergoing Palatoplasty | July 18, 2018 | November 30, 2018 | |
| NCT04683978 | Completed | Effect of Neck Extension on Intraocular Pressure in Patients Undergoing Palatoplasty | February 10, 2021 | December 23, 2021 | |
| NCT06338319 | Enrolling by invitation | N/A | Book Sharing for Toddlers With Clefts | April 16, 2024 | August 2028 |
| NCT03632044 | Enrolling by invitation | Phase 4 | Evaluation of Trigeminal Nerve Blockade | November 20, 2018 | June 30, 2024 |
| NCT02702869 | Enrolling by invitation | Allied Cleft & Craniofacial Quality-Improvement and Research Network (ACCQUIREnet) | October 2016 | December 2031 | |
| NCT06420336 | Not yet recruiting | N/A | QL vs LAI for Palatoplasty | July 1, 2024 | July 30, 2026 |
| NCT05357092 | Not yet recruiting | N/A | Effects of AlignBabyCleft (ABaCleft) | November 2022 | November 2025 |
| NCT05454670 | Recruiting | N/A | The Effect of Collagen Matrix Graft on Postoperative Palatal Fistula Formation After Cleft Palate Repair | August 10, 2022 | May 2024 |
| NCT06072495 | Recruiting | N/A | Etiological Study of Persistent Velopharyngeal Insufficiency in Children With Operated Velopalatine Cleft by Analysis of Velopharyngeal Motor Skills in Static and Dynamic MRI | October 1, 2023 | December 2024 |
| NCT04342234 | Recruiting | Neural Network to Calculate Morphology of the Cleft Palate to Reduce Cleft Lip and Palate Treatment Burden. | March 5, 2020 | December 2025 | |
| NCT03537976 | Recruiting | N/A | Targeting Surgeons' Decision-Making for Cleft Lip Surgery | January 31, 2018 | August 31, 2025 |
| NCT04928352 | Recruiting | Phase 3 | Nebulized Bupivacaine Analgesia for Cleft Palate Repair | June 14, 2021 | June 20, 2024 |
| NCT04928391 | Recruiting | Phase 3 | A Single Bolus of Dexmedetomidine Versus Nalbuphine in Postoperative Agitation | June 20, 2021 | May 20, 2025 |
| NCT04478201 | Recruiting | N/A | Comparing the Side-lying Sleep Positioning to Back-lying in Infants With Cleft Palate | January 28, 2022 | September 2024 |
| NCT05778903 | Recruiting | N/A | Maxillary Nerve Blocks in Children - An MRI Study of the Suprazygomatic Approach | June 7, 2023 | December 31, 2024 |
| NCT01601171 | Recruiting | Genetics of Reproductive Disorders (Including Kallmann Syndrome) and Cleft Lip and/or Palate | March 2012 | March 2030 | |
| NCT03877666 | Recruiting | Assessment of the Influence of Cleft Repair on Microcirculation of the Palate | August 4, 2020 | December 2024 | |
| NCT03868891 | Terminated | N/A | Exercises for Improving Soft Palate and Eustachian Tube Function in Children With Ear Tubes With or Without Cleft Palate | August 16, 2019 | May 31, 2022 |
| NCT03837652 | Unknown status | N/A | Bone-borne Palatal Expander With Corticotomy for Cleft Palate Patients | February 2019 | December 2019 |
| NCT03839290 | Unknown status | Development of the Palate in Bilateral Orofacial Cleft Newborns One Year After Early Neonatal Cheiloplasty | September 2016 | May 2019 | |
| NCT00779961 | Unknown status | N/A | An Investigation for the Optimal Timing of a Cleft Palate Repair | April 2008 | December 2023 |
| NCT00285714 | Unknown status | N/A | 3D Imaging of Hard and Soft Tissue in Orthognathic Surgery | February 2006 | December 2010 |
| NCT02595307 | Unknown status | N/A | Improving Informed Consent for Cleft Palate Repair | May 2014 | December 2017 |
| NCT04023825 | Withdrawn | N/A | Analgesic Contribution of the Suprazygomatic Maxillary Nerve Block for Cleft Palate Surgery in Children | July 1, 2019 | July 1, 2022 |
| NCT03572907 | Withdrawn | Use of Titanium Plate in Rhinoplasty in Patients With Cleft Lip and Palate : Aesthetic and Functional Impact. | October 2018 | February 2019 | |
| NCT02953145 | Withdrawn | Phase 4 | The Use of Fibrin Sealant to Reduce Post Operative Pain in Cleft Palate Surgery | September 1, 2019 | December 1, 2020 |
| NCT02915042 | Withdrawn | Phase 4 | Dexmedetomidine vs Placebo for Pediatric Cleft Palate Repair | December 31, 2017 | December 2019 |
| NCT02688634 | Withdrawn | The Role of Antibiotic Prophylaxis in Cleft Palate and Velopharyngeal Insufficiency Repair | April 2016 | March 2018 | |
| NCT01760330 | Withdrawn | Phase 2 | IV Acetaminophen in Children Undergoing Palatoplasty | December 2015 | December 2016 |
- Disase is a (Disease Ontology)
- DOID:0050567
- Cross Reference ID (Disease Ontology)
- ICD10CM:Q35
- Cross Reference ID (Disease Ontology)
- ICD9CM:749.0
- Cross Reference ID (Disease Ontology)
- MESH:D002972
- Cross Reference ID (Disease Ontology)
- NCI:C87069
- Cross Reference ID (Disease Ontology)
- ORDO:99772
- Cross Reference ID (Disease Ontology)
- SNOMEDCT_US_2023_03_01:156940009
- Cross Reference ID (Disease Ontology)
- UMLS_CUI:C0008925
- Exact Synonym (Disease Ontology)
- Palatoschisis
- HPO Human Phenotype ID (Human Phenotype Ontology)
- HP:0000175
- OrphaNumber from OrphaNet (Orphanet)
- 2014
- ICD10 preferred id (Insert disease from ICD10)
- D0013761
- ICD10 class code (Insert disease from ICD10)
- Q35
- MeSH unique ID (MeSH (Medical Subject Headings))
- D002972