long QT syndrome
Information
- Disease name
- long QT syndrome
- Disease ID
- DOID:2843
- Description
- "An autosomal genetic disease that is characterized by delayed repolarization of the heart following a heartbeat increases the risk of episodes of torsade de pointes (TDP, a form of irregular heartbeat that originates from the ventricles)." [url:http\://en.wikipedia.org/wiki/Long_QT_syndrome]
Disease area statistics
Chromosome band
Annotation
| Genes | Mutation | Description | Source | Links |
|---|
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT05964322 | Active, not recruiting | Cardiac Rehabilitation of Children and Adolescent With Long QT Syndrome | February 2, 2022 | December 31, 2023 | |
| NCT00005250 | Completed | Linkage Study of Long QT Syndrome In An Amish Kindred | January 1990 | December 1992 | |
| NCT00005367 | Completed | Epidemiology of Long QTand Asian Sudden Death in Sleep | February 1993 | January 1995 | |
| NCT00292032 | Completed | Registry of Unexplained Cardiac Arrest | May 2004 | August 30, 2020 | |
| NCT00316459 | Completed | Phase 1 | Study Evaluating the Effects of Multiple Oral Doses of ERB-041 on Cardiac Repolarization in Healthy Subjects | May 2006 | |
| NCT02082431 | Completed | Determine the Incidence of Long QT Amongst a Large Cohort of Subjects Diagnosed With Unilateral or Bilateral Sensorineural Hearing Loss. | August 2014 | July 20, 2020 | |
| NCT02365532 | Completed | Phase 1 | Effect of Oral GS-6615 on Dofetilide-Induced QT Prolongation, Safety, and Tolerability in Healthy Adults | February 2015 | May 2015 |
| NCT02412098 | Completed | Phase 1 | Pharmacokinetics of Eleclazine in Adults With Normal and Impaired Hepatic Function | March 19, 2015 | April 22, 2016 |
| NCT02425189 | Completed | The Canadian National Long QT Syndrome Registry | November 2014 | August 30, 2020 | |
| NCT02441829 | Completed | Phase 1 | Pharmacokinetics of Eleclazine in Adults With Normal and Impaired Renal Function | May 2015 | December 2015 |
| NCT02513940 | Completed | Phase 4 | Influence of Testosterone Administration on Drug-Induced QT Interval Prolongation and Torsades de Pointes | May 2016 | October 19, 2017 |
| NCT02549664 | Completed | Exercise in Genetic Cardiovascular Conditions | May 1, 2015 | November 14, 2022 | |
| NCT02581241 | Completed | N/A | Abnormal QT-Response to the Sudden Tachycardia Provoked by Standing in Individuals With Drug-induced Long QT Syndrome | January 1, 2016 | August 23, 2017 |
| NCT02680080 | Completed | N/A | Effect of Grapefruit on QT Interval in Healthy Volunteers and Patients With Congenital Long QT Syndrome | December 1, 2016 | May 22, 2019 |
| NCT02876380 | Completed | Prospective Identification of Long QT Syndrome in Fetal Life | November 2014 | July 8, 2019 | |
| NCT03182777 | Completed | N/A | Safety of Local Dental Anesthesia in Patients With Cardiac Channelopathies | May 2015 | August 2018 |
| NCT03544918 | Completed | Prevalence of Congenital Long QT Syndrome and Acquired QT Prolongation in a Hospital Cohort | June 2015 | November 6, 2020 | |
| NCT03678311 | Completed | N/A | Long QT Syndrome and Sleep Apnea | March 13, 2019 | April 30, 2019 |
| NCT03834883 | Completed | Phase 4 | Reducing the Risk of Drug-Induced QT Interval Lengthening in Women | March 26, 2019 | May 23, 2024 |
| NCT03868657 | Completed | N/A | The Physiological Effects of Human Ether-a-go-go-Related Gene (hERG)Blockade on Metabolism | January 28, 2019 | March 9, 2020 |
| NCT04124237 | Completed | Long Term Monitoring for Risk of Sudden Death | May 15, 2015 | August 30, 2020 | |
| NCT04328376 | Completed | N/A | Measurement of the Electromechanical Window to Improve the Diagnosis of Congenital Long QT Syndrome | August 28, 2020 | April 23, 2024 |
| NCT04650009 | Completed | Physical Activity in Children With Inherited Cardiac Diseases | May 1, 2020 | February 1, 2021 | |
| NCT04699097 | Completed | The Effect of Azithromycin Use on Conduction System of Heart in COVID-19 Positive Children | July 1, 2020 | November 1, 2020 | |
| NCT04706104 | Completed | QT Measurement Techniques and Anesthesia Management | October 10, 2020 | March 1, 2021 | |
| NCT04712136 | Completed | N/A | Healthy-related Quality of Life and Physical Activity of Children With Cardiac Malformations | February 1, 2021 | June 20, 2023 |
| NCT04728100 | Completed | LQT and Smartphone/Smartwatch | March 22, 2021 | June 12, 2023 | |
| NCT05759962 | Completed | Phase 1 | Phase 1 Study of LQT-1213 in Healthy Adults | September 14, 2022 | March 5, 2023 |
| NCT06375863 | Completed | N/A | QT Changes in Geriatric Patients: a Comparison of Spinal and General Anesthesia | March 29, 2023 | May 29, 2023 |
| NCT00399412 | Completed | ECG Signal Collection From Long QT Syndrome, Wide QRS Complexes, Heart Failure, and Cardiac Resynchronization Patients | November 2006 | December 2007 | |
| NCT00488254 | Completed | The Long QT Syndrome in Pregnancy | June 2007 | April 2008 | |
| NCT00588965 | Completed | N/A | Effect of Beta-blocker Therapy on QTc Response in Exercise and Recovery in Normal Subjects | August 2007 | December 2008 |
| NCT01648205 | Completed | Phase 2 | Long-term Efficacy Study of Sodium Channel Blocker in LQT3 Patients | September 2012 | July 20, 2018 |
| NCT01705925 | Completed | Multicenter Evaluation of Children and Young Adults With Genotype Positive Long QT Syndrome | March 2012 | December 2018 | |
| NCT01849003 | Completed | Phase 1 | Study of the Effect of GS-6615 in Subjects With LQT-3 | May 2013 | November 2014 |
| NCT01903564 | Completed | Fetal and Neonatal Magnetophysiology | March 2014 | June 2018 | |
| NCT00005176 | Completed | Long QT Syndrome-Population Genetics and Cardiac Studies | August 1985 | April 2013 | |
| NCT05903313 | Enrolling by invitation | A Study to Evaluate Accuracy and Validity of the Chang Gung ECG Abnormality Detection Software | October 6, 2023 | February 28, 2024 | |
| NCT04169100 | Recruiting | Phase 4 | Novel Form of Acquired Long QT Syndrome | September 28, 2011 | September 30, 2024 |
| NCT04675788 | Recruiting | Phase 4 | Novel Approaches for Minimizing Drug-Induced QT Interval Lengthening | September 2, 2021 | December 31, 2024 |
| NCT05906732 | Recruiting | Phase 1/Phase 2 | Study of LQT-1213 on QTc-induced Prolongation in Healthy Adult Subjects (Part1) and on Congenital Long QT in Patients Diagnosed With Type 2 or 3 Long QT Syndrome (Part 2). | March 12, 2023 | June 30, 2024 |
| NCT03775954 | Recruiting | Fetal Electrophysiologic Abnormalities in High-Risk Pregnancies Associated With Fetal Demise | July 1, 2018 | April 30, 2024 | |
| NCT06087367 | Recruiting | Building of a Diagnostic/Prognostic Database for Human ERG Variant Effects | September 20, 2021 | March 24, 2025 | |
| NCT05521451 | Recruiting | Clinical Cohort Study - TRUST | March 17, 2021 | December 31, 2031 | |
| NCT04581408 | Recruiting | Phase 2 | Mutation-specific Therapy for the Long QT Syndrome | June 15, 2021 | December 15, 2024 |
| NCT04336644 | Recruiting | N/A | Continuous Versus Intermittent cARdiac Electrical moNitorinG | November 21, 2023 | December 31, 2025 |
| NCT05348564 | Recruiting | N/A | Comparing Direct vs Indirect Methods for Cascade Screening | May 15, 2023 | March 2027 |
| NCT05274646 | Recruiting | Impact on Risk Stratification of Overlap Syndrome Phenotype in Patients With E1784K Mutation in SCN5A | April 5, 2022 | August 4, 2024 | |
| NCT00335036 | Terminated | N/A | Pediatric Lead Extractability and Survival Evaluation (PLEASE) | June 2006 | January 2009 |
| NCT03783975 | Terminated | N/A | KCNQ1 Cascade Screening | March 7, 2019 | December 29, 2022 |
| NCT02439645 | Terminated | A Registry to Determine the Clinical and Genetic Risk Factors for Torsade De Pointes | October 2013 | July 26, 2019 | |
| NCT04441892 | Terminated | N/A | Low Cost QTc Meter for Long QT Syndrome Screening in Primary Care | February 7, 2019 | March 26, 2020 |
| NCT02412709 | Unknown status | Phase 2 | Long QT Syndrome Screening in Newborns | June 2015 | March 2017 |
| NCT04074122 | Unknown status | Electromechanical Profiling of the Long-QT Syndrome (LQTS) | January 1, 2020 | January 1, 2022 | |
| NCT03642405 | Unknown status | Drug-induced Repolarization ECG Changes | August 15, 2018 | January 1, 2022 | |
| NCT00221832 | Unknown status | Molecular Genetic Screening and Identification of Congenital Arrhythmogenic Diseases | October 2003 | December 2011 | |
| NCT04715256 | Unknown status | N/A | Evaluation of the Effects of KCNQ1 Mutation on Insulin Tolerance and Obsessive Compulsive Features in Long QT Romano-Ward Syndrome Patients. | January 8, 2021 | December 2021 |
| NCT02775513 | Unknown status | Metabolism of Patients With Genetically Caused Cardiac Arrhythmia | September 2010 | ||
| NCT02814981 | Unknown status | Hydroxyzine and Risk of Prolongation of QT Interval | November 2015 | October 2017 | |
| NCT02439658 | Unknown status | Genetics of QT Prolongation With Antiarrhythmics | January 2014 | April 30, 2023 |
- Disase is a (Disease Ontology)
- DOID:0060036
- Cross Reference ID (Disease Ontology)
- GARD:6922
- Cross Reference ID (Disease Ontology)
- ICD10CM:I45.81
- Cross Reference ID (Disease Ontology)
- ICD9CM:426.82
- Cross Reference ID (Disease Ontology)
- MESH:D008133
- Cross Reference ID (Disease Ontology)
- MIM:PS192500
- Cross Reference ID (Disease Ontology)
- NCI:C34786
- Cross Reference ID (Disease Ontology)
- ORDO:768
- Cross Reference ID (Disease Ontology)
- SNOMEDCT_US_2023_03_01:9651007
- Cross Reference ID (Disease Ontology)
- UMLS_CUI:C0023976
- Exact Synonym (Disease Ontology)
- long Q-T syndrome
- Exact Synonym (Disease Ontology)
- LQT
- Disase Synonym (Disease Ontology)
- Romano-Ward syndrome
- OMIM Phenotype Series Number (OMIM)
- PS192500
- MeSH unique ID (MeSH (Medical Subject Headings))
- D008133