Annotation Detail
Information
- Associated Genes
- MMP9
- Associated Variants
-
MMP9 MUTATION
MMP9 MUTATION - Associated Disease
- Dilatation of aorta
- Source Database
- DisGeNET
- Description
- In the mouse CaCl2-induced AAA model, deficiency of myeloid TM, but not vascular smooth muscle cell TM, inhibited macrophage accumulation, attenuated proinflammatory cytokine and matrix metalloproteinase-9 production, and finally mitigated elastin destruction and aortic dilatation.
- Pubmed
- 26338301
- Section of the abstract supporting the evidence
- APPROACH AND RESULTS
- Number of the section of the abstract supporting the evidence
- 2
- Number of the sentence supporting the evidence
- 7
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.000542883744160607
Drugs