Annotation Detail
Information
- Associated Genes
- MMP9
- Associated Variants
-
MMP9 MUTATION
MMP9 MUTATION - Associated Disease
- Neoplasm Metastasis
- Source Database
- DisGeNET
- Description
- TNCL increased the expression of several oncogenes, including MMP9, anaplastic lymphoma kinase (ALK), HIF1a and CBLB, and decreased the expression of tumor suppressors including BRD4, PCM1, TFG and KLF6 by modulating mRNA stability through binding to the 3'-untranslated regions of their transcripts, thus ultimately enhancing metastasis activity.
- Pubmed
- 24632608
- Section of the abstract supporting the evidence
- ALL_TEXT_2/3
- Number of the section of the abstract supporting the evidence
- 2
- Number of the sentence supporting the evidence
- 6
- Original source reporting the Gene Disease association
- BeFree,CTD_human,LHGDN,RGD
- DisGENET score for the Gene Disease association
- 0.314998679279923
Drugs