chr19:45409053:> Detail (hg19)

Information

Genome

Assembly Position
hg19 chr19:45,409,053-45,412,650
hg38 chr19:44,905,796-44,909,393 

HGVS

Type Transcript Protein
Summary

MGeND

Clinical significance
Variant entry
GWAS entry
Disease area statistics Show details

Frequency

[No Data.]

Prediction

[No Data.]

ClinVar

Clinical Significance
Review star [No Data.]
Show details
Links
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
[No Data.]
CIViC
[No Data.]
DisGeNET
Score Disease name Description Source Pubmed Links
<0.001 squamous cell carcinoma NA BeFree Detail
0.003 Cardiomyopathy, Dilated NA BeFree,GAD Detail
0.243 Cardiovascular Diseases We included 210 consecutive patients with late-onset AD to investigate whether e... BeFree,CTD_human,GAD,LHGDN 24596166 Detail
0.243 Cardiovascular Diseases The role of apolipoprotein E in neurodegeneration and cardiovascular disease. BeFree,CTD_human,GAD,LHGDN 24754513 Detail
0.243 Cardiovascular Diseases The apoE polymorphism affects the serum lipoprotein levels, and the ESRD patient... BeFree,CTD_human,GAD,LHGDN 25155022 Detail
0.243 Cardiovascular Diseases The APOE gene stands out as an exception, given that it has been identified as b... BeFree,CTD_human,GAD,LHGDN 25159268 Detail
0.243 Cardiovascular Diseases SN gene therapy exerts beneficial effects in cardiovascular animal models in Apo... BeFree,CTD_human,GAD,LHGDN 25377726 Detail
0.243 Cardiovascular Diseases The present meta-analysis confirms that, besides its previously documented influ... BeFree,CTD_human,GAD,LHGDN 25385258 Detail
0.243 Cardiovascular Diseases The results presented demonstrate that the association between ApoE gene and CVD... BeFree,CTD_human,GAD,LHGDN 25413697 Detail
0.243 Cardiovascular Diseases Our findings provide the scientific rationale supporting a novel clinical applic... BeFree,CTD_human,GAD,LHGDN 25731628 Detail
0.243 Cardiovascular Diseases The analysis showed that Braak stages III to VI were significantly predicted by ... BeFree,CTD_human,GAD,LHGDN 26469248 Detail
0.138 Carotid Artery Diseases NA BeFree,CTD_human,GAD Detail
0.002 carotid artery thrombosis NA GAD Detail
0.130 carotid stenosis NA BeFree,CTD_human,GAD Detail
0.002 Chronic Kidney Diseases The Chi-square test, multivariable logistic regression analysis with adjustment ... BeFree 19424605 Detail
0.002 cellulitis NA GAD Detail
0.004 CNS disorder NA BeFree,GAD Detail
0.007 intracranial aneurysm NA BeFree,GAD Detail
0.012 intracranial arteriosclerosis NA GAD,LHGDN Detail
0.029 cerebral infarction Association of the ApoE gene polymorphism and dietary factors with cerebral infa... BeFree,GAD,LHGDN 25730003 Detail
0.062 brain ischemia NA BeFree,GAD Detail
0.087 Transient ischemic attack NA BeFree,GAD,RGD Detail
0.011 cerebral palsy Our findings suggest that genetic variations in one of the sequences regulating ... BeFree,GAD 24786335 Detail
0.036 Cerebrovascular Disorders NA GAD,LHGDN Detail
<0.001 Primary biliary cirrhosis NA BeFree Detail
0.025 cholelithiasis NA BeFree,GAD Detail
<0.001 cholera NA BeFree Detail
0.002 intrahepatic cholestasis NA GAD Detail
0.002 chorioamnionitis NA GAD Detail
0.002 Choroid Diseases NA GAD Detail
0.002 Chromosome Aberrations NA GAD Detail
0.125 Cognition Disorders NA BeFree,CTD_human,GAD Detail
0.003 ulcerative colitis APOE genotyping was performed to evaluate the allele and genotype frequencies in... BeFree,GAD 25624723 Detail
0.005 Colonic Neoplasms NA GAD Detail
0.001 colorectal carcinoma NA BeFree Detail
0.012 Colorectal Neoplasms Apolipoprotein E polymorphism and colorectal neoplasm: results from a meta-analy... BeFree,GAD,LHGDN 25029444 Detail
<0.001 Communication impairment NA BeFree Detail
0.005 Confusion NA GAD Detail
0.006 Febrile Convulsions NA BeFree,GAD,LHGDN Detail
<0.001 Corneal Diseases NA BeFree Detail
0.069 Coronary Arteriosclerosis Common variants of apolipoprotein E and cholesteryl ester transport protein gene... BeFree,GAD 24402318 Detail
0.069 Coronary Arteriosclerosis A systematic review and meta-analysis of 130,000 individuals shows smoking does ... BeFree,GAD 25173947 Detail
0.069 Coronary Arteriosclerosis Fatty acid metabolism in carriers of apolipoprotein E epsilon 4 allele: is it co... BeFree,GAD 25333200 Detail
0.069 Coronary Arteriosclerosis Secretoneurin gene therapy improves hind limb and cardiac ischaemia in Apo E⁻/⁻ ... BeFree,GAD 25377726 Detail
0.069 Coronary Arteriosclerosis Review: Apolipoprotein E (Apo E) gene polymorphism and coronary heart disease in... BeFree,GAD 26142535 Detail
0.260 Coronary heart disease Common variants of apolipoprotein E and cholesteryl ester transport protein gene... BeFree,CTD_human,GAD,LHGDN 24402318 Detail
0.260 Coronary heart disease A systematic review and meta-analysis of 130,000 individuals shows smoking does ... BeFree,CTD_human,GAD,LHGDN 25173947 Detail
0.260 Coronary heart disease Fatty acid metabolism in carriers of apolipoprotein E epsilon 4 allele: is it co... BeFree,CTD_human,GAD,LHGDN 25333200 Detail
0.260 Coronary heart disease Review: Apolipoprotein E (Apo E) gene polymorphism and coronary heart disease in... BeFree,CTD_human,GAD,LHGDN 26142535 Detail
<0.001 Crohn Disease APOE genotyping was performed to evaluate the allele and genotype frequencies in... BeFree 25624723 Detail
0.002 Cross Infection NA GAD Detail
0.003 Cytomegalovirus Infections NA BeFree,GAD Detail
0.003 Cessation of life NA LHGDN Detail
<0.001 Deglutition Disorders As neurodegenerative processes are implicated in swallowing dysfunction, we hypo... BeFree 24261350 Detail
0.019 Delirium NA BeFree,GAD,LHGDN Detail
0.001 Delusions NA BeFree Detail
<0.001 Multi-infarct dementia NA BeFree Detail
0.080 Presenile dementia Apolipoprotein E epsilon 4 genotype and a physically active lifestyle in late li... BeFree 23883793 Detail
0.080 Presenile dementia High apolipoprotein E in cerebrospinal fluid of patients with Lewy body disorder... BeFree 23978325 Detail
0.080 Presenile dementia The presence of apraxia in AD is related to dementia severity and APOE ε4. BeFree 24603451 Detail
0.080 Presenile dementia To explore apolipoprotein E gene variants distribution among the patients of Alz... BeFree 24678786 Detail
0.080 Presenile dementia Results indicate that the relationship between sedentary time and CBF in the lef... BeFree 24685629 Detail
0.080 Presenile dementia The MCI subjects who developed dementia were more likely to carry at least one c... BeFree 24685632 Detail
0.080 Presenile dementia Association of apolipoprotein E-e4 and dementia declines with age. BeFree 24731780 Detail
0.080 Presenile dementia The cluster-derived normal group had significantly fewer APOE ε4 carriers and fe... BeFree 24857234 Detail
0.080 Presenile dementia Apolipoprotein E ε4 (APOE ε4) is a risk factor for β-amyloid deposition in Alzhe... BeFree 24985533 Detail
0.080 Presenile dementia The levels of miR‑193b, exosomal miR‑193b, Aβ, tau, p‑tau, HCY and APOE in sampl... BeFree 25119742 Detail
0.080 Presenile dementia Cognitively healthy NDFAM showed a higher net cognitive gain after CS, as reflec... BeFree 25187003 Detail
0.080 Presenile dementia Increased WMH volume was associated with increased frequency of dementia irrespe... BeFree 25304991 Detail
0.080 Presenile dementia We assessed relative telomere length and apolipoprotein E genotype in subjects w... BeFree 25440562 Detail
0.080 Presenile dementia Influence of socio-demographic features and apolipoprotein E epsilon 4 expressio... BeFree 25466513 Detail
0.080 Presenile dementia We included 209 consecutive late-onset AD patients to find out which factors amo... BeFree 25591674 Detail
0.080 Presenile dementia Apolipoprotein E (APOE) ε4 is an established risk factor for cognitive decline a... BeFree 25599330 Detail
0.080 Presenile dementia Mediation analysis was used to estimate the direct and indirect effects of APOE ... BeFree 25623662 Detail
0.080 Presenile dementia There was a synergistic interaction between depression or apathy and APOE ε4 in ... BeFree 25653291 Detail
0.080 Presenile dementia This article considers APOE ϵ4 effects on cognition in people without dementia, ... BeFree 25711453 Detail
0.080 Presenile dementia The allele frequency of APOE ε4 varies both across and within populations, and t... BeFree 25738563 Detail
0.080 Presenile dementia Subgroup analyses indicated that (1) the significantly increased risk of AD from... BeFree 25763939 Detail
0.080 Presenile dementia We have also established novel methods to express apoE isoforms in mouse brain t... BeFree 25871773 Detail
0.080 Presenile dementia Among persons without dementia, the prevalence of cerebral amyloid pathology as ... BeFree 25988462 Detail
0.080 Presenile dementia These findings indicate the potential clinical utility of amyloid imaging for di... BeFree 25988463 Detail
0.080 Presenile dementia Eleven patients with dementia had apolipoprotein E 4 (ApoE4) and R47H genotypes. BeFree 26076170 Detail
0.080 Presenile dementia Interaction of Apolipoprotein E Genotypes, Lifestyle Factors and Future Risk of ... BeFree 26088392 Detail
0.002 Senile dementia NA BeFree Detail
0.049 Mental Depression There was a synergistic interaction between depression or apathy and APOE ε4 in ... BeFree,GAD 25653291 Detail
0.049 Mental Depression Association between apolipoprotein E gene polymorphism and depression. BeFree,GAD 25979253 Detail
0.016 depressive disorder There was a synergistic interaction between depression or apathy and APOE ε4 in ... BeFree 25653291 Detail
0.016 depressive disorder Association between apolipoprotein E gene polymorphism and depression. BeFree 25979253 Detail
0.003 Dermatomycoses NA LHGDN Detail
0.011 Diabetes These results suggest that previous findings of an association of the TOMM40 sho... BeFree 25044051 Detail
0.032 diabetes mellitus These results suggest that previous findings of an association of the TOMM40 sho... BeFree,GAD 25044051 Detail
0.032 diabetes mellitus Among black APOE ε4 carriers, the strongest predictors of cognitive resilience w... BeFree,GAD 25599330 Detail
0.080 Diabetes Mellitus, Experimental NA RGD Detail
0.022 Diabetes Mellitus, Insulin-Dependent NA BeFree,GAD Detail
0.106 Diabetes Mellitus, Non-Insulin-Dependent Type 2 diabetes is associated with increased expression of APOE, BAX, MMP1, NFKB... BeFree,GAD,LHGDN 23337395 Detail
0.106 Diabetes Mellitus, Non-Insulin-Dependent We assessed relative telomere length and apolipoprotein E genotype in subjects w... BeFree,GAD,LHGDN 25440562 Detail
0.003 Diabetic Angiopathies NA BeFree,GAD Detail
0.046 Diabetic Nephropathy Apo E gene polymorphism affects development of type 2 diabetic nephropathy in As... BeFree,GAD,LHGDN 25196797 Detail
0.006 Diabetic Neuropathies NA BeFree,GAD Detail
0.008 diabetic retinopathy NA BeFree,GAD Detail
0.002 diarrhea NA GAD Detail
0.002 Infantile Diarrhea NA GAD Detail
0.030 Down syndrome Similar efforts are occurring in an extended Colombian family with a PSEN1 mutat... BeFree,GAD,LHGDN 25217249 Detail
0.002 Drug toxicity NA GAD Detail
0.003 Dyskinetic syndrome NA BeFree,LHGDN Detail
0.002 dystonia NA GAD Detail
<0.001 eclampsia NA BeFree Detail
0.002 Edema NA GAD Detail
0.120 Pathological accumulation of air in tissues NA CTD_human Detail
0.006 encephalitis NA BeFree,GAD,LHGDN Detail
<0.001 Experimental Autoimmune Encephalomyelitis NA BeFree Detail
<0.001 endometrial hyperplasia Association of the apolipoprotein E 2 allele with concurrent occurrence of endom... BeFree 25741405 Detail
<0.001 endometriosis NA BeFree Detail
0.004 epilepsy NA BeFree,GAD Detail
0.024 Epilepsy, Temporal Lobe NA BeFree,GAD,LHGDN Detail
0.002 Epilepsy, Post-Traumatic NA GAD Detail
<0.001 Exanthema NA BeFree Detail
0.002 Exophthalmos NA GAD Detail
0.003 Fatigue NA BeFree,GAD Detail
0.016 Fatty Liver Mitochondrial aldehyde dehydrogenase activation by Alda-1 inhibits atheroscleros... BeFree,GAD,LHGDN 25392542 Detail
0.002 Fetal Diseases NA GAD Detail
0.005 Fetal Growth Retardation NA GAD,LHGDN Detail
0.002 Fetal Membranes, Premature Rupture NA GAD Detail
0.003 Gall Bladder Diseases NA BeFree,GAD Detail
0.006 glaucoma NA BeFree,GAD Detail
0.002 Angle Closure Glaucoma NA GAD Detail
0.031 Glaucoma, Open-Angle NA BeFree,GAD,LHGDN Detail
0.003 glioblastoma NA BeFree,GAD Detail
0.003 glomerulonephritis NA BeFree,GAD Detail
<0.001 IgA glomerulonephritis NA BeFree Detail
0.080 membranous glomerulonephritis NA BeFree,RGD Detail
<0.001 Nodular glomerulosclerosis NA BeFree Detail
0.005 Focal glomerulosclerosis NA BeFree,GAD,LHGDN Detail
0.002 gout NA GAD Detail
0.002 Growth Disorders NA GAD Detail
0.003 Guillain-Barre syndrome NA BeFree,GAD Detail
0.004 Hallucinations NA BeFree,GAD Detail
0.002 Head and Neck Neoplasms NA GAD Detail
<0.001 Headache NA BeFree Detail
0.003 Sensorineural Hearing Loss (disorder) NA BeFree,GAD Detail
0.003 cardiac arrest NA BeFree,GAD Detail
0.015 congenital heart defects NA BeFree,GAD Detail
0.014 Heart Diseases Trade-offs in the effects of the apolipoprotein E polymorphism on risks of disea... BeFree,GAD,LHGDN 25482294 Detail
<0.001 Heart failure NA BeFree Detail
<0.001 congestive heart failure NA BeFree Detail
<0.001 Ventricular Septal Defects NA BeFree Detail
<0.001 heart valve disease NA BeFree Detail
0.002 hemiplegia NA GAD Detail
0.003 hemochromatosis NA BeFree,LHGDN Detail
0.007 Hemorrhage NA GAD,LHGDN Detail
0.005 hepatitis NA GAD,LHGDN Detail
0.005 hepatitis B NA BeFree,GAD Detail
<0.001 Hepatitis, Chronic NA BeFree Detail
0.010 hepatitis C NA BeFree,GAD,LHGDN Detail
0.122 Hepatolenticular Degeneration NA CTD_human,GAD Detail
<0.001 Herpes NOS NA BeFree Detail
0.005 genital herpes NA BeFree,GAD Detail
0.003 Herpes Labialis NA BeFree,GAD Detail
0.005 Herpes Simplex Infections NA BeFree,GAD Detail
<0.001 Keratitis, Herpetic NA BeFree Detail
<0.001 Herpes zoster disease NA BeFree Detail
0.002 Herpesviridae Infections NA GAD Detail
0.024 HIV Infections These data replicate and strengthen prior findings of the lack of association be... BeFree,GAD 25388225 Detail
<0.001 Hodgkin Disease NA BeFree Detail
0.004 Huntington disease NA BeFree,GAD Detail
<0.001 Hydrocephalus, Normal Pressure NA BeFree Detail
0.202 Hypercholesterolemia Slovenian children born between 1989 and 2009 (n = 272) with TC >6 mmol/l (231.7... BeFree,CTD_human,GAD,LHGDN 26361156 Detail
0.138 Hypercholesterolemia, Familial Metaanalysis of the weighted 6-SNP score, on the basis of polymorphisms in CELSR... BeFree,CTD_human,GAD 25414277 Detail
0.138 Hypercholesterolemia, Familial Similar to its existing use in the diagnosis of monogenic dyslipidemias such as ... BeFree,CTD_human,GAD 25731628 Detail
<0.001 hyperglycemia NA BeFree Detail
0.005 hyperinsulinism NA BeFree,GAD Detail
0.303 Hyperlipidemia Primary genetic investigation of a hyperlipidemia model: molecular characteristi... BeFree,CTD_human,GAD,LHGDN,RGD 25006576 Detail
0.303 Hyperlipidemia Association of apolipoprotein E gene polymorphism with end-stage renal disease a... BeFree,CTD_human,GAD,LHGDN,RGD 25155022 Detail
0.391 hyperlipoproteinemia type III We evaluated whether and to what extent the APOE genotype modifies the relation ... BeFree,CLINVAR,CTD_human,GAD,ORPHANET 24946908 Detail
0.003 hyperlipoproteinemia type IV NA BeFree,GAD Detail
0.002 Disorders of Excessive Somnolence NA GAD Detail
0.291 Hypertensive disease Hypertension moderates the effect of APOE on 21-year cognitive trajectories. BeFree,CTD_human,GAD,RGD 24956008 Detail
0.291 Hypertensive disease In conclusion, the results of this epistasis study indicated significant associa... BeFree,CTD_human,GAD,RGD 25055800 Detail
0.291 Hypertensive disease These results provide tentative evidence that APOE genotype moderates the associ... BeFree,CTD_human,GAD,RGD 25672766 Detail
0.291 Hypertensive disease Apolipoprotein E, carbon dioxide vasoreactivity, and cognition in older adults: ... BeFree,CTD_human,GAD,RGD 25688603 Detail
0.291 Hypertensive disease Predictors of MCI were APOE ε4 allele (hazard ratio [HR] 1.89; p = 0.008), curre... BeFree,CTD_human,GAD,RGD 25854867 Detail
0.003 pulmonary hypertension NA LHGDN Detail
0.059 Hypertriglyceridemia NA GAD,LHGDN Detail
0.004 Hypobetalipoproteinemias NA BeFree,LHGDN Detail
0.006 hypoglycemia NA BeFree,GAD,LHGDN Detail
0.003 hypopituitarism NA BeFree,GAD Detail
0.005 hypothyroidism NA BeFree,GAD Detail
<0.001 Illusions NA BeFree Detail
0.002 Neonatal disorder NA GAD Detail
0.019 Inflammation NA GAD Detail
0.003 Inflammatory Bowel Diseases Genetic association of apolipoprotein E polymorphisms with inflammatory bowel di... BeFree,GAD 25624723 Detail
0.009 Insulin resistance NA GAD Detail
0.015 ischemia NA BeFree,GAD,LHGDN Detail
0.005 Creutzfeldt-Jakob disease NA BeFree,GAD Detail
0.003 Ketosis NA BeFree,GAD Detail
0.011 Kidney Diseases Our meta-analysis supports that the ApoE ε2 allele and ACACB rs2268388 C>T might... BeFree,GAD 25262148 Detail
0.003 Kidney Failure, Acute NA BeFree,GAD Detail
0.018 Kidney Failure, Chronic Association of apolipoprotein E gene polymorphism with end-stage renal disease a... BeFree,GAD 25155022 Detail
0.002 Kidney Neoplasm NA GAD Detail
0.005 Premature Obstetric Labor NA GAD Detail
0.002 Lead Poisoning NA GAD Detail
0.005 Learning Disorders NA GAD Detail
<0.001 Lecithin Acyltransferase Deficiency NA BeFree Detail
<0.001 Left-Sided Heart Failure NA BeFree Detail
0.003 leukemia NA BeFree,LHGDN Detail
0.003 chronic lymphocytic leukemia NA BeFree,GAD Detail
<0.001 lipodystrophy NA BeFree Detail
<0.001 Hyperlipoproteinemia Type I NA BeFree Detail
0.013 liver cirrhosis NA BeFree,GAD,LHGDN Detail
0.005 Liver Cirrhosis, Alcoholic NA BeFree,GAD Detail
0.002 Biliary cirrhosis NA GAD Detail
0.001 Liver diseases NA BeFree Detail
0.001 Liver neoplasms NA BeFree Detail
0.007 Chronic Obstructive Airway Disease NA GAD Detail
0.123 Lung Neoplasms NA CTD_human,LHGDN Detail
0.011 Lupus Erythematosus, Systemic NA BeFree,GAD,LHGDN Detail
0.003 lymphoma NA BeFree,GAD Detail
0.002 Lymphoma, Non-Hodgkin NA GAD Detail
0.001 Machado-Joseph disease The role of apolipoprotein E as a risk factor for an earlier age at onset for Ma... BeFree 25369462 Detail
<0.001 macular degeneration NA BeFree Detail
0.006 malaria NA BeFree,LHGDN Detail
0.002 Malaria, Falciparum NA GAD Detail
<0.001 Malignant neoplasm of stomach NA BeFree Detail
0.002 Animal Mammary Neoplasms NA GAD Detail
<0.001 melanoma NA BeFree Detail
0.081 Memory Disorders NA BeFree,GAD Detail
0.002 Mental Retardation NA BeFree Detail
0.120 Mercury Poisoning NA CTD_human Detail
0.003 Metabolic Diseases NA BeFree,GAD Detail
0.003 mitral valve stenosis NA BeFree,GAD Detail
0.002 Mouth, Edentulous NA GAD Detail
0.233 multiple sclerosis NA BeFree,CTD_human,GAD,LHGDN Detail
<0.001 spinal muscular atrophy NA BeFree Detail
0.003 myopathy NA BeFree,GAD Detail
0.003 myasthenia gravis NA BeFree,GAD Detail
<0.001 Mydriasis NA BeFree Detail
0.340 myocardial infarction Meta-analysis of apolipoprotein E gene polymorphism and susceptibility of myocar... BeFree,CLINVAR,CTD_human,GAD,LHGDN 25111308 Detail
<0.001 Myoclonus NA BeFree Detail
<0.001 myopia NA BeFree Detail
<0.001 myositis NA BeFree Detail
<0.001 Myotonic dystrophy NA BeFree Detail
0.002 nasopharyngitis NA GAD Detail
<0.001 Neoplasm Metastasis Secretomes are a potential source of molecular targets for cancer therapies and ... BeFree 25098600 Detail
0.022 nephrotic syndrome NA BeFree,GAD,LHGDN Detail
0.127 Nerve Degeneration NA CTD_human,GAD Detail
0.009 nervous system disorder NA BeFree,GAD Detail
<0.001 neuroblastoma NA BeFree Detail
<0.001 Neuromuscular Diseases NA BeFree Detail
<0.001 Niemann-Pick Diseases NA BeFree Detail
0.002 Obesity, Morbid NA GAD Detail
<0.001 Disorder of the optic nerve NA BeFree Detail
<0.001 optic neuritis NA BeFree Detail
<0.001 Degenerative polyarthritis NA BeFree Detail
0.010 osteoporosis NA BeFree,GAD Detail
0.007 Osteoporosis, Postmenopausal NA GAD Detail
<0.001 ovarian carcinoma NA BeFree Detail
0.080 Pancreatic Neoplasm NA RGD Detail
0.007 pancreatitis NA GAD Detail
<0.001 papilloma NA BeFree Detail
0.080 Parkinson disease Among PD patients without dementia, the APOE ε4 allele was only associated with ... BeFree,GAD,LHGDN 25178429 Detail
0.002 Perceptual Disorders NA GAD Detail
0.002 Periodontal Diseases NA GAD Detail
0.003 Peripheral neuropathy NA BeFree,GAD Detail
<0.001 Pituitary Diseases NA BeFree Detail
0.006 polycystic ovary syndrome NA BeFree,GAD Detail
<0.001 Postherpetic neuralgia NA BeFree Detail
0.021 Postoperative Complications NA GAD Detail
0.012 pre-eclampsia NA GAD Detail
0.005 Pregnancy Complications NA GAD Detail
0.002 Pregnancy Complications, Cardiovascular NA GAD Detail
0.002 Prenatal Exposure Delayed Effects NA GAD Detail
0.003 Prostatic Neoplasms NA BeFree,LHGDN Detail
0.120 proteinuria NA CTD_human Detail
<0.001 pseudoxanthoma elasticum Increased cholesterol biosynthesis, elevated PCSK9 levels and reduced APOE mRNA ... BeFree 25064003 Detail
0.129 psoriasis NA BeFree,CTD_human,GAD Detail
0.005 Tension Headache NA BeFree,GAD Detail
0.007 Psychomotor Disorders NA GAD Detail
0.003 Psychotic Disorders NA BeFree Detail
0.003 pulmonary embolism NA BeFree,GAD Detail
<0.001 quadriplegia NA BeFree Detail
0.002 Rectal Neoplasms NA GAD Detail
0.009 kidney failure NA BeFree,GAD Detail
<0.001 retinal degeneration NA BeFree Detail
<0.001 Retinal Diseases NA BeFree Detail
0.003 Rett syndrome NA BeFree,GAD Detail
0.002 Kaposi sarcoma NA GAD Detail
0.250 schizophrenia In each case, a single gene is represented in a plurality of epistatic interacti... BeFree,CTD_human,GAD,LHGDN,RGD 25403528 Detail
<0.001 Schizophreniform Disorders NA BeFree Detail
<0.001 systemic scleroderma NA BeFree Detail
0.005 Sclerosis NA GAD Detail
0.127 Seizures NA BeFree,CTD_human,GAD Detail
<0.001 Age-related cataract The KLC1 and APOE genes may be novel susceptibility genes for age-related catara... BeFree 25883527 Detail
0.005 Sensation Disorders NA GAD Detail
<0.001 Shared Paranoid Disorder NA BeFree Detail
0.002 Shock, Cardiogenic NA GAD Detail
<0.001 Shy-Drager Syndrome NA BeFree Detail
<0.001 Sickle Cell Trait NA BeFree Detail
<0.001 siderosis NA BeFree Detail
0.007 Sleep Apnea Syndromes NA BeFree,GAD Detail
<0.001 Sleep disturbances NA BeFree Detail
0.005 Spina Bifida Cystica NA GAD,LHGDN Detail
0.005 Compression of spinal cord NA BeFree,GAD,LHGDN Detail
0.003 Spinal Cord Diseases NA BeFree,GAD Detail
0.002 Spinal Osteophytosis NA GAD Detail
0.120 Splenomegaly NA CTD_human Detail
0.002 spondylosis NA GAD Detail
0.003 Stomach Neoplasms NA LHGDN Detail
0.003 Stomatitis, Herpetic NA BeFree,GAD Detail
0.004 post-traumatic stress disorder The Number of Cysteine Residues per Mole in Apolipoprotein E Is Associated With ... BeFree,LHGDN 25751510 Detail
0.001 Stress, Psychological NA BeFree Detail
0.115 Cerebrovascular accident The data about apolipoprotein E gene (APOE) genotype and the risk of stroke are ... BeFree,GAD,LHGDN 24846706 Detail
0.115 Cerebrovascular accident Association of the ApoE gene polymorphism and dietary factors with cerebral infa... BeFree,GAD,LHGDN 25730003 Detail
0.055 Subarachnoid Hemorrhage NA BeFree,GAD,LHGDN Detail
0.002 Substance Withdrawal Syndrome NA GAD Detail
0.005 sudden infant death syndrome NA BeFree,GAD,LHGDN Detail
0.006 progressive supranuclear palsy NA BeFree,GAD Detail
<0.001 Tangier disease NA BeFree Detail
0.006 tetralogy of Fallot NA BeFree,GAD,LHGDN Detail
0.007 thrombosis NA GAD Detail
<0.001 tic disorder NA BeFree Detail
0.002 Tinea Versicolor NA GAD Detail
<0.001 Tremor Analyses also considered APOE genotype and tremor- vs. rigidity-dominant phenoty... BeFree 25596881 Detail
0.003 Trisomy NA BeFree,GAD Detail
0.002 Unconscious State NA GAD Detail
0.002 Unipolar Depression NA BeFree Detail
<0.001 Unspecified idiopathic peripheral neuropathy NA BeFree Detail
0.002 uremia NA GAD Detail
0.024 Vascular Diseases Influence of APOE-2 genotype on the relation between adiposity and plasma lipid ... BeFree,GAD 24946908 Detail
0.024 Vascular Diseases APOE genotype was significantly associated with performance on several different... BeFree,GAD 25247594 Detail
0.024 Vascular Diseases Predictors of MCI were APOE ε4 allele (hazard ratio [HR] 1.89; p = 0.008), curre... BeFree,GAD 25854867 Detail
0.002 Venous Thrombosis NA GAD Detail
0.002 Virilism NA GAD Detail
0.001 Virus Diseases Apolipoprotein E and protection against hepatitis E viral infection in American ... BeFree 26096528 Detail
0.002 Low Vision NA GAD Detail
0.002 Vitamin B 12 Deficiency NA GAD Detail
0.002 Vitamin K Deficiency NA GAD Detail
0.002 Weight Gain NA GAD Detail
0.003 xanthomatosis NA BeFree,GAD Detail
<0.001 Cerebral Thrombosis NA BeFree Detail
0.002 holoprosencephaly NA GAD Detail
<0.001 B-Cell Lymphomas NA BeFree Detail
<0.001 Pleural Effusion, Malignant NA BeFree Detail
0.005 Tooth Loss NA GAD Detail
0.004 motor neuron disease NA BeFree,LHGDN Detail
0.002 Lymphoma, AIDS-Related NA GAD Detail
0.003 Peripheral Vascular Diseases NA BeFree,GAD Detail
0.167 cerebral amyloid angiopathy To gain insight into different cerebral amyloid angiopathy (CAA) phenotypes and ... BeFree,CTD_human,GAD,LHGDN 25716356 Detail
0.167 cerebral amyloid angiopathy APOE ε4 is associated with recurrent ICH in nonlobar brain regions, providing fu... BeFree,CTD_human,GAD,LHGDN 26115730 Detail
0.002 Yin Deficiency NA GAD Detail
<0.001 Alagille syndrome NA BeFree Detail
<0.001 hepatitis E Apolipoprotein E and protection against hepatitis E viral infection in American ... BeFree 26096528 Detail
0.015 Neurofibrillary degeneration (morphologic abnormality) APOE [Latin Small Letter Open E]4 is a major risk factor for late-onset Alzheime... BeFree 23715207 Detail
0.005 Polycystic Kidney, Autosomal Dominant NA GAD,LHGDN Detail
0.002 Epilepsy, Complex Partial NA GAD Detail
<0.001 autosomal recessive polycystic kidney disease NA BeFree Detail
0.002 essential hypertension NA BeFree Detail
<0.001 Encephalopathies NA BeFree Detail
0.006 Agitation NA BeFree,GAD Detail
0.001 Apathy Reduced brain-derived neurotrophic factor (BDNF) signaling is considered as a pa... BeFree 25024337 Detail
0.001 Apathy There was a synergistic interaction between depression or apathy and APOE ε4 in ... BeFree 25653291 Detail
<0.001 Synovial Cyst NA BeFree Detail
0.003 Alcohol abuse NA BeFree,GAD Detail
<0.001 soft neurological signs NA BeFree Detail
0.011 Depressive Symptoms Predictors of MCI were APOE ε4 allele (hazard ratio [HR] 1.89; p = 0.008), curre... BeFree,GAD 25854867 Detail
<0.001 Depressive Syndrome NA BeFree Detail
<0.001 Intravenous Drug Abuse NA BeFree Detail
0.003 cataract NA BeFree,GAD Detail
<0.001 Pancreatitis, Chronic NA BeFree Detail
<0.001 Cervical myelopathy NA BeFree Detail
0.002 Left Ventricular Hypertrophy NA GAD Detail
<0.001 Deep Vein Thrombosis NA BeFree Detail
0.006 Migraine Disorders NA BeFree,GAD Detail
0.080 sciatic neuropathy NA RGD Detail
<0.001 Complex partial seizures NA BeFree Detail
<0.001 Genital ulceration NA BeFree Detail
<0.001 Sensory neuropathy NA BeFree Detail
<0.001 Atrophic condition of skin APOE ɛ4 was associated with atrophic hippocampal volume in MRI markers, increase... BeFree 24838911 Detail
0.002 Premature Birth NA GAD Detail
0.009 Intracranial Hemorrhages NA GAD Detail
0.002 intracranial hypertension NA GAD Detail
0.049 Myocardial Ischemia Secretoneurin gene therapy improves hind limb and cardiac ischaemia in Apo E⁻/⁻ ... BeFree,GAD,LHGDN 25377726 Detail
<0.001 Arterial thrombosis Synthetic gestagens exert differential effects on arterial thrombosis and aortic... BeFree 24923668 Detail
<0.001 Adenocarcinoma of lung (disorder) Secretomes are a potential source of molecular targets for cancer therapies and ... BeFree 25098600 Detail
<0.001 Patau syndrome NA BeFree Detail
<0.001 hypoplastic left heart syndrome NA BeFree Detail
<0.001 lingual-facial-buccal dyskinesia NA BeFree Detail
<0.001 low tension glaucoma NA BeFree Detail
<0.001 Common ventricle NA BeFree Detail
<0.001 Malignant neoplasm of gallbladder NA BeFree Detail
0.008 Lipid Metabolism Disorders NA BeFree,GAD Detail
<0.001 migraine with aura NA BeFree Detail
<0.001 Eyelid Xanthoma NA BeFree Detail
<0.001 Hearing Loss, Mixed Conductive-Sensorineural NA BeFree Detail
0.001 acute myocardial infarction NA BeFree Detail
<0.001 Old myocardial infarction NA BeFree Detail
0.002 Atherosclerosis of aorta No renal phenotype in human phospholipid transfer protein transgenic apolipoprot... BeFree 25651711 Detail
<0.001 Disease of capillaries NA BeFree Detail
0.002 iron deficiency anemia NA GAD Detail
0.003 Malnutrition NA BeFree,LHGDN Detail
0.002 AIDS-Related Opportunistic Infections NA GAD Detail
0.004 Prion Diseases Seven patients had high levels of PrP, low Aβ42, high APOE-4, and 40% nerve cell... BeFree,GAD 26226132 Detail
0.002 Akathisia, Drug-Induced NA GAD Detail
0.005 Aneurysm, Ruptured NA GAD Detail
0.002 Aortic Aneurysm, Abdominal NA BeFree Detail
0.003 Smith-Lemli-Opitz syndrome NA BeFree,GAD Detail
0.002 Amyloid Neuropathies, Familial NA GAD Detail
0.006 exfoliation syndrome NA BeFree,GAD Detail
0.002 Paramyxoviridae Infections NA GAD Detail
<0.001 hepatoblastoma NA BeFree Detail
<0.001 teratocarcinoma NA BeFree Detail
<0.001 Niemann-Pick disease, type C NA BeFree Detail
<0.001 Systolic hypertension NA BeFree Detail
0.001 Lesion of brain NA BeFree Detail
<0.001 Premature aging syndrome NA BeFree Detail
<0.001 Psychological symptom NA BeFree Detail
<0.001 Psychiatric symptom NA BeFree Detail
<0.001 Dysphoric mood NA BeFree Detail
<0.001 Bradykinesia NA BeFree Detail
<0.001 Hallucinations, Visual NA BeFree Detail
0.014 Memory impairment The apolipoprotein E ε4 (ApoE ε4) allele not only represents the strongest singl... BeFree,GAD 24989884 Detail
0.014 Memory impairment Compared with the stable memory trajectory, high Αβ (relative risk ratio [RRR] =... BeFree,GAD 25585532 Detail
0.014 Memory impairment In conclusion, behavioural Alzheimer's disease presentations are characterized b... BeFree,GAD 26141491 Detail
<0.001 Amnesia, Anterograde We measured RA, anterograde amnesia (AA), brain measures, apolipoprotein-E statu... BeFree 25068664 Detail
0.002 Personality Traits NA GAD Detail
<0.001 Extrapyramidal sign NA BeFree Detail
<0.001 Sensory denervation disorder NA BeFree Detail
0.122 Mental deterioration NA GAD,GWASCAT Detail
0.009 Cerebral atrophy It was therefore investigated whether the association between load of WMHs and b... BeFree 24313901 Detail
0.009 Cerebral atrophy This study evaluates the individual, as well as relative and joint value of indi... BeFree 24371799 Detail
0.009 Cerebral atrophy Genetic interaction of PICALM and APOE is associated with brain atrophy and cogn... BeFree 24613704 Detail
0.008 Pick Disease of the Brain Only 1 FTD patient (homozygous for apolipoprotein E ε4) displayed high cortical ... BeFree,GAD 25655625 Detail
<0.001 Dementia associated with alcoholism NA BeFree Detail
<0.001 Alcohol withdrawal syndrome NA BeFree Detail
0.002 Age-related cognitive decline Perhaps less well known, and certainly less well characterized, is that this ϵ4 ... BeFree 25711453 Detail
<0.001 Alcohol or Other Drugs use NA BeFree Detail
0.006 Inclusion Body Myositis (disorder) NA BeFree,GAD,LHGDN Detail
<0.001 Anaplastic thyroid carcinoma NA BeFree Detail
<0.001 Prodrome A lower EF performance in cognitively intact older APOE ε4 allele carriers might... BeFree 25365563 Detail
0.008 coronary stenosis APOE gene polymorphism and risk of coronary stenosis in Pakistani population. BeFree,GAD 25883965 Detail
0.003 Malignant neoplasm of lung NA BeFree,GAD Detail
<0.001 Parkinsonian Disorders NA BeFree Detail
<0.001 Drug usage NA BeFree Detail
0.017 Disease Progression NA GAD Detail
0.002 Persistent Vegetative State NA GAD Detail
0.005 Ventricular Dysfunction, Left NA GAD Detail
<0.001 Parasitemia NA BeFree Detail
0.002 Sepsis NA GAD Detail
<0.001 Carcinoma of ampulla of Vater NA BeFree Detail
<0.001 Apraxia of Phonation APOE ε4 influences β-amyloid deposition in primary progressive aphasia and speec... BeFree 24985533 Detail
<0.001 Dilatation of aorta Osteoprotegerin deficiency limits angiotensin II-induced aortic dilatation and r... BeFree 25301844 Detail
<0.001 Cerebral Vasospasm NA BeFree Detail
<0.001 Chronic Periodontitis Apolipoprotein E gene polymorphisms in relation to chronic periodontitis, period... BeFree 25545672 Detail
<0.001 Oropharyngeal Dysphagia We report the association between ApoE 4 homozygous genotype and self-reported o... BeFree 24261350 Detail
<0.001 Progressive intrahepatic cholestasis (disorder) NA BeFree Detail
<0.001 Amyloid nephropathy NA BeFree Detail
<0.001 Localized amyloidosis NA BeFree Detail
<0.001 Familial Cerebral Amyloid Angiopathy NA BeFree Detail
<0.001 Hereditary Cerebral Amyloid Angiopathy, Dutch Type NA BeFree Detail
<0.001 Amyloidosis, Primary Cutaneous NA BeFree Detail
<0.001 Renal glomerular disease NA BeFree Detail
<0.001 Acute nephropathy NA BeFree Detail
<0.001 Leukoencephalopathies NA BeFree Detail
<0.001 Triplegia NA BeFree Detail
0.003 macular retinal edema NA BeFree,LHGDN Detail
0.001 Exudative age-related macular degeneration Polymorphisms in the APOE gene and the location of retinal fluid in eyes with ne... BeFree 25077528 Detail
<0.001 Cortical cataract To study whether presenilin 1 (PSEN1), apolipoprotein E (APOE), and kinesin ligh... BeFree 25883527 Detail
<0.001 Impaired glucose tolerance NA BeFree Detail
0.005 Herpes encephalitis NA BeFree,GAD Detail
0.003 Familial Alzheimer Disease (FAD) NA BeFree Detail
<0.001 Behavioral tic NA BeFree Detail
<0.001 Iron Overload NA BeFree Detail
<0.001 Sexual abuse NA BeFree Detail
0.009 Primary Progressive Aphasia (disorder) APOE ε4 influences β-amyloid deposition in primary progressive aphasia and speec... BeFree,GAD 24985533 Detail
<0.001 Tuberous xanthoma NA BeFree Detail
<0.001 Xanthoma NA BeFree Detail
<0.001 Poisoning syndrome NA BeFree Detail
0.003 Obesity, Abdominal NA BeFree,GAD Detail
0.004 Restenosis NA BeFree,GAD Detail
0.025 Senile Plaques APOE [Latin Small Letter Open E]4 is a major risk factor for late-onset Alzheime... BeFree,GAD 23715207 Detail
<0.001 Segmental glomerulosclerosis NA BeFree Detail
<0.001 Infarction, Lacunar NA BeFree Detail
0.055 Atrophic NA GAD,LHGDN Detail
<0.001 Arteriovenous hemangioma NA BeFree Detail
0.007 frontotemporal dementia Only 1 FTD patient (homozygous for apolipoprotein E ε4) displayed high cortical ... BeFree,GAD 25655625 Detail
<0.001 carotid artery dissection NA BeFree Detail
0.002 Vertebral Artery Dissection NA GAD Detail
0.200 Impaired cognition In linear mixed models, controlling for age, gender, education, and apolipoprote... BeFree,GAD,GWASCAT 23954042 Detail
0.200 Impaired cognition Apolipoprotein E (ApoE) is the most well-described genetic risk factor for Alzhe... BeFree,GAD,GWASCAT 24261350 Detail
0.200 Impaired cognition Genetic interaction of PICALM and APOE is associated with brain atrophy and cogn... BeFree,GAD,GWASCAT 24613704 Detail
0.200 Impaired cognition The alternative prodrome hypothesis predicts that the APOE-ε4 allele would be as... BeFree,GAD,GWASCAT 24853824 Detail
0.200 Impaired cognition The combined effects of metabolic syndrome and the apolipoprotein E and CYP46 ge... BeFree,GAD,GWASCAT 24924840 Detail
0.200 Impaired cognition Age, APOE ε4, and decline in intellectually and socially stimulating recreationa... BeFree,GAD,GWASCAT 24933483 Detail
0.200 Impaired cognition Hypertension moderated the effects of APOE ε4 on the rate of change for cognitiv... BeFree,GAD,GWASCAT 24956008 Detail
0.200 Impaired cognition Deploying a between-sibling design that allows quasi-experimental variation in g... BeFree,GAD,GWASCAT 25074513 Detail
0.200 Impaired cognition Moreover, the interaction of APOE by age on brain morphology may accelerate the ... BeFree,GAD,GWASCAT 25114090 Detail
0.200 Impaired cognition Fatty acid metabolism in carriers of apolipoprotein E epsilon 4 allele: is it co... BeFree,GAD,GWASCAT 25333200 Detail
0.200 Impaired cognition APOE genotype, along with other biomarkers, may be used in the future to assist ... BeFree,GAD,GWASCAT 25355028 Detail
0.200 Impaired cognition Influence of socio-demographic features and apolipoprotein E epsilon 4 expressio... BeFree,GAD,GWASCAT 25466513 Detail
0.200 Impaired cognition Higher UACR values were significantly associated with cognitive dysfunction in t... BeFree,GAD,GWASCAT 25530658 Detail
0.200 Impaired cognition Apolipoprotein E (ApoE) ε4 allele is a known genetic risk factor for AD, which n... BeFree,GAD,GWASCAT 25551132 Detail
0.200 Impaired cognition APOE allele might play a role in the occurrence of cognitive impairment after mT... BeFree,GAD,GWASCAT 25586534 Detail
0.200 Impaired cognition Although APOE ε4 carriers are at high risk for cognitive decline, our findings s... BeFree,GAD,GWASCAT 25599330 Detail
0.200 Impaired cognition Interactive effect of APOE genotype and blood pressure on cognitive decline: the... BeFree,GAD,GWASCAT 25672766 Detail
0.200 Impaired cognition Effects of vascular risk factors and APOE ε4 on white matter integrity and cogni... BeFree,GAD,GWASCAT 25672924 Detail
0.200 Impaired cognition The ε4 allele of apolipoprotein E (APOE ε4) is a well-established risk factor fo... BeFree,GAD,GWASCAT 25738563 Detail
0.200 Impaired cognition Among persons without dementia, the prevalence of cerebral amyloid pathology as ... BeFree,GAD,GWASCAT 25988462 Detail
0.002 Age-associated memory impairment NA BeFree Detail
0.004 Glaucoma, Primary Open Angle Analysis of the expression and polymorphism of APOE, HSP, BDNF, and GRIN2B genes... BeFree 25893192 Detail
<0.001 Stable angina NA BeFree Detail
<0.001 Silent myocardial ischemia NA BeFree Detail
<0.001 Aortic aneurysm without mention of rupture NOS NA BeFree Detail
<0.001 Dissection of aorta NA BeFree Detail
<0.001 Chronic liver disease NA BeFree Detail
<0.001 Iodine deficiency syndrome NA BeFree Detail
<0.001 Endemic Cretinism NA BeFree Detail
0.009 Complications of Diabetes Mellitus NA GAD Detail
<0.001 Polygenic hypercholesterolemia NA BeFree Detail
<0.001 Cholesteryl Ester Transfer Protein Deficiency NA BeFree Detail
<0.001 Tetralogy of Fallot with pulmonary atresia NA BeFree Detail
<0.001 dementia in parkinson's disease NA BeFree Detail
0.002 Nonorganic psychosis NA BeFree Detail
<0.001 Wernicke-Korsakoff syndrome NA BeFree Detail
0.003 Malignant neoplasm of prostate NA BeFree,GAD Detail
0.002 Pancreatitis, Alcoholic NA GAD Detail
<0.001 Hereditary hemochromatosis NA BeFree Detail
<0.001 Subcortical Vascular Dementia NA BeFree Detail
<0.001 Corticobasal degeneration NA BeFree Detail
<0.001 multiple system atrophy NA BeFree Detail
<0.001 thrombophilia NA BeFree Detail
0.081 Non-alcoholic Fatty Liver Disease NA BeFree,RGD Detail
0.005 Chronic Kidney Insufficiency NA BeFree,GAD Detail
<0.001 Congenital Myotonic Dystrophy NA BeFree Detail
<0.001 Anxiety and fear NA BeFree Detail
<0.001 Mobility poor NA BeFree Detail
<0.001 neuropathy NA BeFree Detail
<0.001 Spastic NA BeFree Detail
0.002 Traumatic cerebral hemorrhage NA GAD Detail
<0.001 endometrial carcinoma Association of the apolipoprotein E 2 allele with concurrent occurrence of endom... BeFree 25741405 Detail
0.228 dementia Apolipoprotein E epsilon 4 genotype and a physically active lifestyle in late li... BeFree,GAD,LHGDN 23883793 Detail
0.228 dementia High apolipoprotein E in cerebrospinal fluid of patients with Lewy body disorder... BeFree,GAD,LHGDN 23978325 Detail
0.228 dementia The presence of apraxia in AD is related to dementia severity and APOE ε4. BeFree,GAD,LHGDN 24603451 Detail
0.228 dementia To explore apolipoprotein E gene variants distribution among the patients of Alz... BeFree,GAD,LHGDN 24678786 Detail
0.228 dementia Results indicate that the relationship between sedentary time and CBF in the lef... BeFree,GAD,LHGDN 24685629 Detail
0.228 dementia The MCI subjects who developed dementia were more likely to carry at least one c... BeFree,GAD,LHGDN 24685632 Detail
0.228 dementia Association of apolipoprotein E-e4 and dementia declines with age. BeFree,GAD,LHGDN 24731780 Detail
0.228 dementia The cluster-derived normal group had significantly fewer APOE ε4 carriers and fe... BeFree,GAD,LHGDN 24857234 Detail
0.228 dementia Apolipoprotein E ε4 (APOE ε4) is a risk factor for β-amyloid deposition in Alzhe... BeFree,GAD,LHGDN 24985533 Detail
0.228 dementia The levels of miR‑193b, exosomal miR‑193b, Aβ, tau, p‑tau, HCY and APOE in sampl... BeFree,GAD,LHGDN 25119742 Detail
0.228 dementia Cognitively healthy NDFAM showed a higher net cognitive gain after CS, as reflec... BeFree,GAD,LHGDN 25187003 Detail
0.228 dementia Increased WMH volume was associated with increased frequency of dementia irrespe... BeFree,GAD,LHGDN 25304991 Detail
0.228 dementia We assessed relative telomere length and apolipoprotein E genotype in subjects w... BeFree,GAD,LHGDN 25440562 Detail
0.228 dementia Influence of socio-demographic features and apolipoprotein E epsilon 4 expressio... BeFree,GAD,LHGDN 25466513 Detail
0.228 dementia We included 209 consecutive late-onset AD patients to find out which factors amo... BeFree,GAD,LHGDN 25591674 Detail
0.228 dementia Apolipoprotein E (APOE) ε4 is an established risk factor for cognitive decline a... BeFree,GAD,LHGDN 25599330 Detail
0.228 dementia Mediation analysis was used to estimate the direct and indirect effects of APOE ... BeFree,GAD,LHGDN 25623662 Detail
0.228 dementia There was a synergistic interaction between depression or apathy and APOE ε4 in ... BeFree,GAD,LHGDN 25653291 Detail
0.228 dementia This article considers APOE ϵ4 effects on cognition in people without dementia, ... BeFree,GAD,LHGDN 25711453 Detail
0.228 dementia The allele frequency of APOE ε4 varies both across and within populations, and t... BeFree,GAD,LHGDN 25738563 Detail
0.228 dementia Subgroup analyses indicated that (1) the significantly increased risk of AD from... BeFree,GAD,LHGDN 25763939 Detail
0.228 dementia We have also established novel methods to express apoE isoforms in mouse brain t... BeFree,GAD,LHGDN 25871773 Detail
0.228 dementia Among persons without dementia, the prevalence of cerebral amyloid pathology as ... BeFree,GAD,LHGDN 25988462 Detail
0.228 dementia These findings indicate the potential clinical utility of amyloid imaging for di... BeFree,GAD,LHGDN 25988463 Detail
0.228 dementia Eleven patients with dementia had apolipoprotein E 4 (ApoE4) and R47H genotypes. BeFree,GAD,LHGDN 26076170 Detail
0.228 dementia Interaction of Apolipoprotein E Genotypes, Lifestyle Factors and Future Risk of ... BeFree,GAD,LHGDN 26088392 Detail
0.002 Overweight NA BeFree Detail
0.002 body mass NA GAD Detail
<0.001 Cerebrovascular amyloidosis NA BeFree Detail
0.018 Sleep Apnea, Obstructive The relationship between obstructive sleep apnea syndrome and apolipoprotein E g... BeFree,GAD,LHGDN 25613112 Detail
0.002 Paralysed NA GAD Detail
0.045 Neurodegenerative Disorders APOE [Latin Small Letter Open E]4 is a major risk factor for late-onset Alzheime... BeFree,GAD,LHGDN 23715207 Detail
0.045 Neurodegenerative Disorders We included 210 consecutive patients with late-onset AD to investigate whether e... BeFree,GAD,LHGDN 24596166 Detail
0.045 Neurodegenerative Disorders In this regard, the GHRH-GH-IGF-1/Insulin, TOR-S6K1,NAD(+)-Sirtuin, P53, Klotho ... BeFree,GAD,LHGDN 25038521 Detail
0.045 Neurodegenerative Disorders Here we focused on long-living participants of the Long Life Family Study (LLFS)... BeFree,GAD,LHGDN 25482294 Detail
0.011 Hepatitis C, Chronic PCSK9, apolipoprotein E and lipoviral particles in chronic hepatitis C genotype ... BeFree,GAD 25463543 Detail
<0.001 Neurobehavioral Manifestations NA BeFree Detail
0.003 Mood Disorders NA BeFree,GAD Detail
<0.001 Hypersensitive syndrome NA BeFree Detail
<0.001 Amyotrophic Lateral Sclerosis, Guam Form NA BeFree Detail
0.002 Mercury Poisoning, Nervous System NA GAD Detail
<0.001 Post-Concussion Syndrome NA BeFree Detail
0.009 Olfaction Disorders NA GAD Detail
0.002 Menopause present (finding) NA GAD Detail
0.009 Carotid Atherosclerosis NA BeFree,GAD Detail
<0.001 Chronic anxiety NA BeFree Detail
<0.001 Factor V Leiden mutation NA BeFree Detail
0.005 Alcohol Withdrawal Seizures NA BeFree,GAD,LHGDN Detail
<0.001 Severe depression NA BeFree Detail
<0.001 cortex bone disorders Mean expression of APOE and TOMM40 mRNA levels were higher in VL homozygotes com... BeFree 24439168 Detail
0.002 Intraocular pressure disorder NA BeFree Detail
<0.001 Carcinogenesis NA BeFree Detail
<0.001 Cardiovascular Infections NA BeFree Detail
0.049 Mental Depression The aim of this study was to investigate the role of serotonin in depression, se... BeFree 17183148 Detail
0.011 Depressive Symptoms The aim of this study was to investigate the role of serotonin in depression, se... BeFree 17183148 Detail
0.094 hyperhomocysteinemia NA BeFree,GAD,LHGDN,RGD Detail
0.016 depressive disorder The aim of this study was to investigate the role of serotonin in depression, se... BeFree 17183148 Detail
<0.001 prostate carcinoma NA BeFree Detail
0.002 hepatopulmonary syndrome NA GAD Detail
<0.001 Progressive Neoplastic Disease NA BeFree Detail
0.003 breast carcinoma Longitudinal assessment of cognitive changes associated with adjuvant treatment ... BeFree 24789331 Detail
0.003 breast carcinoma APOE genotype, along with other biomarkers, may be used in the future to assist ... BeFree 25355028 Detail
<0.001 Vascular rupture NA BeFree Detail
<0.001 Carcinoma of lung NA BeFree Detail
<0.001 Tardive Dyskinesia NA BeFree Detail
<0.001 Secondary malignant neoplasm of lymph node Our study indicates that APOE is a potential indicator of metastatic lung ADC an... BeFree 25098600 Detail
<0.001 heavy drinking NA BeFree Detail
0.002 Pregnancy loss NA GAD Detail
0.002 Chronic progressive chorea NA GAD Detail
<0.001 colon carcinoma NA BeFree Detail
<0.001 stomach carcinoma NA BeFree Detail
<0.001 Central neuroblastoma NA BeFree Detail
<0.001 Emotional distress NA BeFree Detail
<0.001 Anxiety state NA BeFree Detail
0.001 Dissecting aneurysm of the thoracic aorta NA BeFree Detail
<0.001 bile duct carcinoma NA BeFree Detail
<0.001 Varicella zoster NA BeFree Detail
0.085 Infarction, Middle Cerebral Artery NA GAD,RGD Detail
0.001 hyperuricemia Apolipoprotein E gene polymorphisms are associated with primary hyperuricemia in... BeFree 25356596 Detail
<0.001 Cardiovascular Pathology The altered binding to lipids and receptors by ApoE isoforms E2 and E4 results i... BeFree 24754513 Detail
<0.001 Hyperlipoproteinemia Type IIa NA BeFree Detail
0.001 Alzheimer Disease, Early Onset None of these patients had pathogenic mutations, APOE ε4 or other high-risk alle... BeFree 26354483 Detail
<0.001 Intracranial Atherosclerosis NA BeFree Detail
0.005 Frontotemporal Lobar Degeneration NA BeFree,GAD Detail
0.002 Memory Loss NA BeFree Detail
0.005 Subarachnoid Hemorrhage, Aneurysmal NA GAD Detail
0.003 CADASIL Syndrome NA BeFree,GAD Detail
<0.001 Carotid Artery Plaque NA BeFree Detail
<0.001 Primary Progressive Nonfluent Aphasia NA BeFree Detail
0.001 Inclusion Body Myopathy, Sporadic NA BeFree Detail
0.002 Lead Poisoning, Nervous System, Adult NA GAD Detail
0.007 Vasospasm, Intracranial NA GAD Detail
0.007 brain infarction NA GAD Detail
<0.001 Acute Cerebrovascular Accidents NA BeFree Detail
0.123 Multiple Sclerosis, Relapsing-Remitting NA BeFree,CTD_human,GAD Detail
<0.001 Dystonia, Primary NA BeFree Detail
<0.001 Hypoxic-Ischemic Encephalopathy NA BeFree Detail
0.005 Hypoxia-Ischemia, Brain NA GAD Detail
0.002 Lupus Vasculitis, Central Nervous System NA GAD Detail
<0.001 thrombocytosis NA BeFree Detail
<0.001 Spots on skin NA BeFree Detail
0.005 Sleep Disorders NA BeFree,GAD Detail
0.002 Blood Coagulation Disorders, Inherited NA GAD Detail
<0.001 Arteriopathic disease We evaluated whether and to what extent the APOE genotype modifies the relation ... BeFree 24946908 Detail
0.002 Cognitive deterioration NA BeFree Detail
<0.001 Fat redistribution NA BeFree Detail
0.002 Endothelial dysfunction In this review, we focus on the main genes that are epigenetically modified duri... BeFree 25433555 Detail
0.002 Endothelial dysfunction Xyloketal B attenuates atherosclerotic plaque formation and endothelial dysfunct... BeFree 25874925 Detail
<0.001 Cholesterol gallstones NA BeFree Detail
0.120 Drug-Induced Liver Injury NA CTD_human Detail
<0.001 Gallbladder sludge NA BeFree Detail
<0.001 Loss of memory ability NA BeFree Detail
0.001 Psychotic symptom NA BeFree Detail
0.002 traumatic brain injury NA GAD Detail
<0.001 arteriolosclerosis NA BeFree Detail
0.002 Chlamydophila Infections NA GAD Detail
0.001 Cerebral Ischemia NA BeFree Detail
<0.001 transient cerebral ischemia NA BeFree Detail
0.003 ovarian neoplasm NA LHGDN Detail
0.002 Microsatellite Instability NA GAD Detail
0.015 cholecystolithiasis NA BeFree,GAD Detail
0.001 Vascular inflammations NA BeFree Detail
0.018 Ischemic stroke Apolipoprotein E polymorphisms and ischaemic stroke: a two-center Greek study. BeFree,GAD 24471738 Detail
0.008 Acute coronary syndrome NA BeFree,GAD Detail
0.003 Leukoaraiosis NA LHGDN Detail
0.005 coronary restenosis NA GAD Detail
0.002 cervical dystonia NA GAD Detail
<0.001 Tauopathies NA BeFree Detail
<0.001 Progressive multiple sclerosis NA BeFree Detail
<0.001 Drug Resistant Epilepsy NA BeFree Detail
<0.001 Macroangiopathy NA BeFree Detail
<0.001 Malignant neoplasm of ovary NA BeFree Detail
<0.001 Myxoid cyst NA BeFree Detail
<0.001 frontal dementia NA BeFree Detail
0.001 Drusen NA BeFree Detail
0.003 Stenosis NA LHGDN Detail
0.007 major depressive disorder NA BeFree,GAD Detail
0.040 Mild cognitive disorder Our findings demonstrate that higher TC levels are observed long before the clin... BeFree,GAD 24241689 Detail
0.040 Mild cognitive disorder Our findings suggest that SPARE-AD and ADAS-Cog in combination offer the highest... BeFree,GAD 24371799 Detail
0.040 Mild cognitive disorder Using Hotelling's T(2) test, we found significant morphological deformation in A... BeFree,GAD 24453132 Detail
0.040 Mild cognitive disorder Participants were 74 patients with clinically confirmed aMCI (33 APOE ε4 noncarr... BeFree,GAD 24749727 Detail
0.040 Mild cognitive disorder At baseline, older age, APOE-ε4 carriership, lower total cholesterol levels, and... BeFree,GAD 24825566 Detail
0.040 Mild cognitive disorder The analyses were performed in the MCI population and subpopulations enriched by... BeFree,GAD 25022537 Detail
0.040 Mild cognitive disorder We measured RA, anterograde amnesia (AA), brain measures, apolipoprotein-E statu... BeFree,GAD 25068664 Detail
0.040 Mild cognitive disorder Source analysis of spontaneous magnetoencephalograpic activity in healthy aging ... BeFree,GAD 25079806 Detail
0.040 Mild cognitive disorder The interaction of APOE genotype by age in amnestic mild cognitive impairment: a... BeFree,GAD 25114090 Detail
0.040 Mild cognitive disorder Posterior cingulate γ-aminobutyric acid and glutamate/glutamine are reduced in a... BeFree,GAD 25169676 Detail
0.040 Mild cognitive disorder Only APOE-inclusive risk scores associated with worse memory and incident MCI/LO... BeFree,GAD 25189118 Detail
0.040 Mild cognitive disorder Influence of the APOE ε4 allele and mild cognitive impairment diagnosis in the d... BeFree,GAD 25281603 Detail
0.040 Mild cognitive disorder APOE and mild cognitive impairment: the Framingham Heart Study. BeFree,GAD 25497326 Detail
0.040 Mild cognitive disorder Combining serum and urine biomarkers in the early diagnosis of mild cognitive im... BeFree,GAD 25532446 Detail
0.040 Mild cognitive disorder We used whole-exome sequencing to identify variants other than APOE associated w... BeFree,GAD 25559091 Detail
0.040 Mild cognitive disorder To investigate the population-based interaction between a biological variable (A... BeFree,GAD 25653291 Detail
0.040 Mild cognitive disorder Five top susceptible single nucleotide polymorphisms (SNPs) in three loci in ZNF... BeFree,GAD 25731621 Detail
0.040 Mild cognitive disorder Predictors of MCI were APOE ε4 allele (hazard ratio [HR] 1.89; p = 0.008), curre... BeFree,GAD 25854867 Detail
0.002 Blood pressure finding NA GAD Detail
0.005 Systemic arterial pressure NA GAD Detail
<0.001 Recurrent genital herpes simplex NA BeFree Detail
<0.001 Left ventricular systolic dysfunction NA BeFree Detail
<0.001 Anxiety neurosis (finding) NA BeFree Detail
<0.001 Lipoatrophy NA BeFree Detail
<0.001 Degenerative disorder NA BeFree Detail
0.002 Fetal Nutrition Disorders NA GAD Detail
<0.001 Adenoma of large intestine NA BeFree Detail
<0.001 Peripheral arterial occlusive disease NA BeFree Detail
0.002 Postoperative confusion NA BeFree Detail
0.120 hearing impairment NA CTD_human Detail
<0.001 Arteriosclerosis of aorta NA BeFree Detail
0.006 Cognitive changes Longitudinal assessment of cognitive changes associated with adjuvant treatment ... BeFree 24789331 Detail
0.006 Cognitive changes We stratified all analyses by race.Using the Modified Mini-Mental State Examinat... BeFree 25599330 Detail
0.006 Cognitive changes General linear mixed-effects models were used to investigate the relationship be... BeFree 26245925 Detail
0.006 Cognitive changes Overall, our results point to education as a protective factor that may help to ... BeFree 26408498 Detail
0.001 Vascular lesions NA BeFree Detail
0.008 Mammary Neoplasms NA GAD,LHGDN Detail
<0.001 Hippocampal sclerosis NA BeFree Detail
0.043 Hypertriglyceridemia result NA GAD Detail
0.022 colorectal cancer NA BeFree,GAD Detail
0.005 brain edema NA BeFree,GAD Detail
0.002 Sjogren's syndrome NA GAD Detail
0.002 Chronic Kidney Diseases NA BeFree Detail
<0.001 Mobility Limitation NA BeFree Detail
0.120 Renal Insufficiency NA BeFree,CTD_human Detail
<0.001 Cirrhosis NA BeFree Detail
<0.001 early onset schizophrenia NA BeFree Detail
<0.001 Nephrotic Syndrome, Minimal Change NA BeFree Detail
<0.001 Hyperlipoproteinemia Type IIb NA BeFree Detail
<0.001 Peripheral Arterial Diseases NA BeFree Detail
<0.001 Severe Sepsis NA BeFree Detail
<0.001 Hard drusen NA BeFree Detail
<0.001 Soft drusen NA BeFree Detail
<0.001 INCLUSION BODY MYOPATHY WITH EARLY-ONSET PAGET DISEASE AND FRONTOTEMPORAL DEMENTIA NA BeFree Detail
<0.001 Coronary heart disease, susceptibility to, 5 NA BeFree Detail
<0.001 SPEECH-SOUND DISORDER NA BeFree Detail
<0.001 FRAGILE X TREMOR/ATAXIA SYNDROME NA BeFree Detail
0.014 Aural atresia, congenital Immunohistochemistry was quantified for Aβ42, apoE, apoE E4 and smooth muscle ac... BeFree 25195061 Detail
0.014 Aural atresia, congenital Among individuals with advanced CAA, cSS tends to occur in individuals with rela... BeFree 25320098 Detail
0.014 Aural atresia, congenital This neuropathologically defined CAA cohort suggests that CSS and APOE ε2 are re... BeFree 25716356 Detail
0.014 Aural atresia, congenital Convexal subarachnoid hemorrhage presented an APOE-ɛ2 overrepresentation and CAA... BeFree 25735919 Detail
<0.001 NEUROTICISM NA BeFree Detail
<0.001 Myeloproliferative disorder, chronic, with eosinophilia NA BeFree Detail
<0.001 Creutzfeldt-Jakob Disease, Sporadic NA BeFree Detail
<0.001 Pyruvate dehydrogenase E3-binding protein deficiency NA BeFree Detail
0.002 Venous thromboembolism NA GAD Detail
<0.001 Dementia, familial Danish NA BeFree Detail
<0.001 Familial hypobetalipoproteinemia NA BeFree Detail
0.001 Amyotrophic Lateral Sclerosis, Sporadic NA BeFree Detail
0.121 Alzheimer disease 2 NA BeFree,CTD_human Detail
<0.001 INTELLIGENCE QUANTITATIVE TRAIT LOCUS 1 NA BeFree Detail
0.120 Macular Degeneration, Age-Related, 1 NA CTD_human Detail
0.126 coronary artery disease The aim of this study was to investigate the expression of circulating microRNAs... BeFree,GAD,LHGDN 25656948 Detail
0.002 Memory Impairment Adverse Event NA GAD Detail
0.006 Mixed hyperlipidemia (disorder) NA BeFree,GAD Detail
<0.001 Daytime somnolence NA BeFree Detail
0.005 liver carcinoma NA BeFree,LHGDN Detail
0.002 Chronic kidney disease stage 5 Association of apolipoprotein E gene polymorphism with end-stage renal disease a... BeFree 25155022 Detail
<0.001 Iatrogenic Creutzfeldt-Jakob disease NA BeFree Detail
<0.001 Pediatric Obesity NA BeFree Detail
<0.001 clinical depression NA BeFree Detail
0.007 WARFARIN SENSITIVITY (disorder) NA GAD Detail
0.494 Lipoprotein glomerulopathy Apolipoprotein e mutation and double filtration plasmapheresis therapy on a new ... BeFree,CLINVAR,CTD_human,GAD,ORPHANET,UNIPROT 25300642 Detail
<0.001 Hypothalamic-pituitary-adrenal axis dysfunction NA BeFree Detail
0.440 Alzheimer's disease The interaction between PON1 genes (rs662 and rs85460) and ApoE genes showed syn... BeFree 24965284 Detail
<0.001 Steatohepatitis Mitochondrial aldehyde dehydrogenase activation by Alda-1 inhibits atheroscleros... BeFree 25392542 Detail
0.071 Dementia, Vascular The interaction between PON1 genes (rs662 and rs85460) and ApoE genes showed syn... BeFree 24965284 Detail
<0.001 Combined hyperlipidemia NA BeFree Detail
<0.001 Alcoholic Steatohepatitis NA BeFree Detail
<0.001 Executive dysfunction NA BeFree Detail
0.002 Weight Gain Adverse Event NA GAD Detail
0.002 Infection of amniotic sac and membranes, unspecified, unspecified trimester, not applicable or unspecified NA GAD Detail
<0.001 Glycogen storage disease type Ia NA BeFree Detail
0.002 Recurrent pregnancy loss NA GAD Detail
<0.001 Visuospatial deficit NA BeFree Detail
0.003 Amyloid angiopathy NA BeFree Detail
<0.001 Acquired CJD NA BeFree Detail
0.016 Plaque, Amyloid NA BeFree,GAD Detail
0.120 Plaque, Atherosclerotic NA CTD_human Detail
0.051 Cerebral Hemorrhage NA GAD,LHGDN Detail
<0.001 Early-Stage Breast Carcinoma Apolipoprotein E genotype and cognitive function in postmenopausal women with ea... BeFree 25355028 Detail
<0.001 hyperalphalipoproteinemia 1 NA BeFree Detail
<0.001 Parkinson disease, late-onset Cognitive, neuropsychiatric, and motor features associated with apolipoprotein E... BeFree 24646656 Detail
0.005 Hypotension Adverse Event NA GAD Detail
0.009 Ischemic Cerebrovascular Accident NA BeFree Detail
<0.001 Single Ventricle Defect NA BeFree Detail
<0.001 Prodromal Period NA BeFree Detail
<0.001 Mild dementia NA BeFree Detail
<0.001 Severe dementia NA BeFree Detail
0.002 Homocysteinemia NA BeFree Detail
0.002 Mixed dementia NA BeFree Detail
<0.001 Progressive cGVHD NA BeFree Detail
<0.001 Dementia due to Alzheimer's disease (disorder) We included 210 consecutive patients with late-onset AD to investigate whether e... BeFree 24596166 Detail
0.008 Infection NA LHGDN Detail
0.002 GRN-related frontotemporal dementia NA BeFree Detail
<0.001 Dysexecutive syndrome Sixty per cent of patients with behavioural Alzheimer's disease and 40% of those... BeFree 26141491 Detail
0.005 Psychomotor Agitation NA GAD Detail
<0.001 abetalipoproteinemia NA BeFree Detail
0.002 Congenital Abnormality NA GAD Detail
0.071 Dementia, Vascular This study assessed the roles of Tau gene short tandem repeats (STRs) nested wit... BeFree 22176350 Detail
0.122 Spontaneous abortion NA CTD_human,GAD Detail
0.003 acquired immunodeficiency syndrome NA BeFree,GAD Detail
<0.001 acromegaly NA BeFree Detail
<0.001 Acute Disease NA BeFree Detail
<0.001 acute pancreatitis NA BeFree Detail
0.120 adenocarcinoma NA BeFree,CTD_human Detail
0.005 adenoma NA BeFree,GAD Detail
<0.001 Adrenal Cortex Diseases Mean expression of APOE and TOMM40 mRNA levels were higher in VL homozygotes com... BeFree 24439168 Detail
0.006 AIDS Dementia Complex NA BeFree,GAD Detail
0.002 Albuminuria NA GAD Detail
0.002 Alcohol Amnestic Disorder NA GAD Detail
0.013 Alcoholic Intoxication, Chronic NA BeFree,GAD Detail
0.014 Amnesia NA BeFree,GAD Detail
<0.001 Post-traumatic amnesia NA BeFree Detail
<0.001 retrograde amnesia We measured RA, anterograde amnesia (AA), brain measures, apolipoprotein-E statu... BeFree 25068664 Detail
0.128 amyloidosis APOE ε4, the major genetic risk factor for late-onset AD, has been associated wi... BeFree,CTD_human,GAD 24929969 Detail
0.017 amyotrophic lateral sclerosis Lack of association between APOE gene polymorphisms and amyotrophic lateral scle... BeFree,GAD 24918518 Detail
0.017 amyotrophic lateral sclerosis Treatment of adult microglia with apolipoprotein E suppressed the M0-homeostatic... BeFree,GAD 25381879 Detail
<0.001 Cooley's anemia NA BeFree Detail
0.005 Anemia, Sickle Cell NA BeFree,GAD Detail
0.002 Aneurysm NA BeFree Detail
0.012 Angina Pectoris NA GAD Detail
<0.001 Angina Pectoris, Variant NA BeFree Detail
0.005 Angina, Unstable NA BeFree,GAD Detail
<0.001 Anomia NA BeFree Detail
0.005 Anoxia NA GAD,LHGDN Detail
0.002 Anxiety Disorders NA BeFree Detail
0.002 aortic aneurysm NA BeFree Detail
<0.001 Aortic Rupture NA BeFree Detail
0.006 aortic valve stenosis NA BeFree,GAD,LHGDN Detail
0.005 aphasia NA GAD Detail
<0.001 Apraxias The presence of apraxia in AD is related to dementia severity and APOE ε4. BeFree 24603451 Detail
0.207 arteriosclerosis Overexpression of CCN3 inhibits inflammation and progression of atherosclerosis ... BeFree,CTD_human,GAD 24722330 Detail
0.207 arteriosclerosis Apolipoprotein A1 (ApoA1) and apolipoprotein E (ApoE) mimetic peptides have attr... BeFree,CTD_human,GAD 25036240 Detail
0.207 arteriosclerosis The objective of this study was to investigate the effect of Lactobacillus acido... BeFree,CTD_human,GAD 25261526 Detail
0.207 arteriosclerosis Secretoneurin gene therapy improves hind limb and cardiac ischaemia in Apo E⁻/⁻ ... BeFree,CTD_human,GAD 25377726 Detail
0.207 arteriosclerosis Finally, we studied the effect of 3BDO on oxLDL-altered PDI protein level in apo... BeFree,CTD_human,GAD 25389050 Detail
0.207 arteriosclerosis The serum levels of atherosclerosis-related inflammatory factors in ApoE-/- mice... BeFree,CTD_human,GAD 25889019 Detail
0.207 arteriosclerosis Here, we evaluated the contribution of CD39 to atherogenesis in the apolipoprote... BeFree,CTD_human,GAD 26121751 Detail
0.207 arteriosclerosis IRF2BP2-deficient macrophages worsened atherosclerosis in irradiated low-density... BeFree,CTD_human,GAD 26195219 Detail
0.009 Congenital arteriovenous malformation NA BeFree,GAD,LHGDN Detail
0.006 rheumatoid arthritis NA BeFree,GAD,LHGDN Detail
<0.001 asthma NA BeFree Detail
0.001 Astrocytoma NA BeFree Detail
0.302 atherosclerosis Overexpression of CCN3 inhibits inflammation and progression of atherosclerosis ... BeFree,CTD_human,GAD,LHGDN 24722330 Detail
0.302 atherosclerosis Apolipoprotein A1 (ApoA1) and apolipoprotein E (ApoE) mimetic peptides have attr... BeFree,CTD_human,GAD,LHGDN 25036240 Detail
0.302 atherosclerosis The objective of this study was to investigate the effect of Lactobacillus acido... BeFree,CTD_human,GAD,LHGDN 25261526 Detail
0.302 atherosclerosis Secretoneurin gene therapy improves hind limb and cardiac ischaemia in Apo E⁻/⁻ ... BeFree,CTD_human,GAD,LHGDN 25377726 Detail
0.302 atherosclerosis Finally, we studied the effect of 3BDO on oxLDL-altered PDI protein level in apo... BeFree,CTD_human,GAD,LHGDN 25389050 Detail
0.302 atherosclerosis The serum levels of atherosclerosis-related inflammatory factors in ApoE-/- mice... BeFree,CTD_human,GAD,LHGDN 25889019 Detail
0.302 atherosclerosis Here, we evaluated the contribution of CD39 to atherogenesis in the apolipoprote... BeFree,CTD_human,GAD,LHGDN 26121751 Detail
0.302 atherosclerosis IRF2BP2-deficient macrophages worsened atherosclerosis in irradiated low-density... BeFree,CTD_human,GAD,LHGDN 26195219 Detail
0.005 atrial fibrillation NA GAD Detail
<0.001 Tooth Attrition NA BeFree Detail
0.006 autistic disorder NA BeFree,GAD,LHGDN Detail
<0.001 Bacterial Infections NA BeFree Detail
0.002 Chronic Kidney Diseases The chi-square test and multivariable logistic regression analysis with adjustme... BeFree 19406964 Detail
0.004 Mental disorders NA BeFree,GAD Detail
0.003 Behcet Syndrome NA BeFree,GAD Detail
0.005 beta thalassemia NA BeFree,GAD Detail
0.003 Bile Duct Neoplasms NA LHGDN Detail
0.002 Biliary Tract Neoplasm NA GAD Detail
<0.001 bipolar disorder NA BeFree Detail
0.002 Malignant neoplasm of urinary bladder NA GAD Detail
<0.001 Blood Coagulation Disorders NA BeFree Detail
0.002 Metabolic Bone Disorder NA GAD Detail
0.002 Brain Damage, Chronic NA GAD Detail
0.003 Brain Diseases NA BeFree,GAD Detail
<0.001 Brain Neoplasms NA BeFree Detail
0.010 Malignant neoplasm of breast Longitudinal assessment of cognitive changes associated with adjuvant treatment ... BeFree,GAD 24789331 Detail
0.010 Malignant neoplasm of breast APOE genotype, along with other biomarkers, may be used in the future to assist ... BeFree,GAD 25355028 Detail
0.005 calcinosis NA GAD Detail
0.002 cutaneous candidiasis NA GAD Detail
0.002 Carbon Monoxide Poisoning NA GAD Detail
<0.001 Malignant tumor of colon NA BeFree Detail
<0.001 Rectal Carcinoma NA BeFree Detail
0.003 renal cell carcinoma NA BeFree,GAD Detail
Annotation

Annotations

DescrptionSourceLinks
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We included 210 consecutive patients with late-onset AD to investigate whether education, gender, na... DisGeNET Detail
The role of apolipoprotein E in neurodegeneration and cardiovascular disease. DisGeNET Detail
The apoE polymorphism affects the serum lipoprotein levels, and the ESRD patients who are e4 and e2 ... DisGeNET Detail
The APOE gene stands out as an exception, given that it has been identified as being relevant in CVD... DisGeNET Detail
SN gene therapy exerts beneficial effects in cardiovascular animal models in Apo E(-/-) mice without... DisGeNET Detail
The present meta-analysis confirms that, besides its previously documented influence on Alzheimer's ... DisGeNET Detail
The results presented demonstrate that the association between ApoE gene and CVD may be modulated by... DisGeNET Detail
Our findings provide the scientific rationale supporting a novel clinical application for APOE genot... DisGeNET Detail
The analysis showed that Braak stages III to VI were significantly predicted by having 1 or more APO... DisGeNET Detail
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The Chi-square test, multivariable logistic regression analysis with adjustment for covariates, as w... DisGeNET Detail
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Association of the ApoE gene polymorphism and dietary factors with cerebral infarction and circulati... DisGeNET Detail
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Our findings suggest that genetic variations in one of the sequences regulating the expression of AP... DisGeNET Detail
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APOE genotyping was performed to evaluate the allele and genotype frequencies in 378 Saudi subjects ... DisGeNET Detail
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Apolipoprotein E polymorphism and colorectal neoplasm: results from a meta-analysis. DisGeNET Detail
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Common variants of apolipoprotein E and cholesteryl ester transport protein genes in male patients w... DisGeNET Detail
A systematic review and meta-analysis of 130,000 individuals shows smoking does not modify the assoc... DisGeNET Detail
Fatty acid metabolism in carriers of apolipoprotein E epsilon 4 allele: is it contributing to higher... DisGeNET Detail
Secretoneurin gene therapy improves hind limb and cardiac ischaemia in Apo E⁻/⁻ mice without influen... DisGeNET Detail
Review: Apolipoprotein E (Apo E) gene polymorphism and coronary heart disease in Asian populations. DisGeNET Detail
Common variants of apolipoprotein E and cholesteryl ester transport protein genes in male patients w... DisGeNET Detail
A systematic review and meta-analysis of 130,000 individuals shows smoking does not modify the assoc... DisGeNET Detail
Fatty acid metabolism in carriers of apolipoprotein E epsilon 4 allele: is it contributing to higher... DisGeNET Detail
Review: Apolipoprotein E (Apo E) gene polymorphism and coronary heart disease in Asian populations. DisGeNET Detail
APOE genotyping was performed to evaluate the allele and genotype frequencies in 378 Saudi subjects ... DisGeNET Detail
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As neurodegenerative processes are implicated in swallowing dysfunction, we hypothesized that the pr... DisGeNET Detail
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Apolipoprotein E epsilon 4 genotype and a physically active lifestyle in late life: analysis of gene... DisGeNET Detail
High apolipoprotein E in cerebrospinal fluid of patients with Lewy body disorders is associated with... DisGeNET Detail
The presence of apraxia in AD is related to dementia severity and APOE ε4. DisGeNET Detail
To explore apolipoprotein E gene variants distribution among the patients of Alzheimer's disease and... DisGeNET Detail
Results indicate that the relationship between sedentary time and CBF in the left hippocampus differ... DisGeNET Detail
The MCI subjects who developed dementia were more likely to carry at least one copy of the APOE ε4 a... DisGeNET Detail
Association of apolipoprotein E-e4 and dementia declines with age. DisGeNET Detail
The cluster-derived normal group had significantly fewer APOE ε4 carriers and fewer who progressed t... DisGeNET Detail
Apolipoprotein E ε4 (APOE ε4) is a risk factor for β-amyloid deposition in Alzheimer's disease demen... DisGeNET Detail
The levels of miR‑193b, exosomal miR‑193b, Aβ, tau, p‑tau, HCY and APOE in samples from APP/PS1 doub... DisGeNET Detail
Cognitively healthy NDFAM showed a higher net cognitive gain after CS, as reflected in their MoCA sc... DisGeNET Detail
Increased WMH volume was associated with increased frequency of dementia irrespective of APOE ε4 sta... DisGeNET Detail
We assessed relative telomere length and apolipoprotein E genotype in subjects with dementia (n=70) ... DisGeNET Detail
Influence of socio-demographic features and apolipoprotein E epsilon 4 expression on the prevalence ... DisGeNET Detail
We included 209 consecutive late-onset AD patients to find out which factors among educational level... DisGeNET Detail
Apolipoprotein E (APOE) ε4 is an established risk factor for cognitive decline and the development o... DisGeNET Detail
Mediation analysis was used to estimate the direct and indirect effects of APOE alleles on AD pathol... DisGeNET Detail
There was a synergistic interaction between depression or apathy and APOE ε4 in further elevating th... DisGeNET Detail
This article considers APOE ϵ4 effects on cognition in people without dementia, the extent to which ... DisGeNET Detail
The allele frequency of APOE ε4 varies both across and within populations, and the size of the effec... DisGeNET Detail
Subgroup analyses indicated that (1) the significantly increased risk of AD from current smoking was... DisGeNET Detail
We have also established novel methods to express apoE isoforms in mouse brain to study apoE-related... DisGeNET Detail
Among persons without dementia, the prevalence of cerebral amyloid pathology as determined by positr... DisGeNET Detail
These findings indicate the potential clinical utility of amyloid imaging for differential diagnosis... DisGeNET Detail
Eleven patients with dementia had apolipoprotein E 4 (ApoE4) and R47H genotypes. DisGeNET Detail
Interaction of Apolipoprotein E Genotypes, Lifestyle Factors and Future Risk of Dementia-Related Mor... DisGeNET Detail
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There was a synergistic interaction between depression or apathy and APOE ε4 in further elevating th... DisGeNET Detail
Association between apolipoprotein E gene polymorphism and depression. DisGeNET Detail
There was a synergistic interaction between depression or apathy and APOE ε4 in further elevating th... DisGeNET Detail
Association between apolipoprotein E gene polymorphism and depression. DisGeNET Detail
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These results suggest that previous findings of an association of the TOMM40 short allele with bette... DisGeNET Detail
These results suggest that previous findings of an association of the TOMM40 short allele with bette... DisGeNET Detail
Among black APOE ε4 carriers, the strongest predictors of cognitive resilience were, in relative ord... DisGeNET Detail
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Type 2 diabetes is associated with increased expression of APOE, BAX, MMP1, NFKB1, PDGFB, SPP1, and ... DisGeNET Detail
We assessed relative telomere length and apolipoprotein E genotype in subjects with dementia (n=70) ... DisGeNET Detail
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Apo E gene polymorphism affects development of type 2 diabetic nephropathy in Asian populations, esp... DisGeNET Detail
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Similar efforts are occurring in an extended Colombian family with a PSEN1 mutation, in APOE ε4 homo... DisGeNET Detail
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Association of the apolipoprotein E 2 allele with concurrent occurrence of endometrial hyperplasia a... DisGeNET Detail
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Mitochondrial aldehyde dehydrogenase activation by Alda-1 inhibits atherosclerosis and attenuates he... DisGeNET Detail
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Trade-offs in the effects of the apolipoprotein E polymorphism on risks of diseases of the heart, ca... DisGeNET Detail
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These data replicate and strengthen prior findings of the lack of association between ApoE ε4 and co... DisGeNET Detail
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Slovenian children born between 1989 and 2009 (n = 272) with TC >6 mmol/l (231.7 mg/dl) or >5 mmol/l... DisGeNET Detail
Metaanalysis of the weighted 6-SNP score, on the basis of polymorphisms in CELSR2 (cadherin, EGF LAG... DisGeNET Detail
Similar to its existing use in the diagnosis of monogenic dyslipidemias such as familial hypercholes... DisGeNET Detail
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Primary genetic investigation of a hyperlipidemia model: molecular characteristics and variants of t... DisGeNET Detail
Association of apolipoprotein E gene polymorphism with end-stage renal disease and hyperlipidemia in... DisGeNET Detail
We evaluated whether and to what extent the APOE genotype modifies the relation between adiposity an... DisGeNET Detail
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Hypertension moderates the effect of APOE on 21-year cognitive trajectories. DisGeNET Detail
In conclusion, the results of this epistasis study indicated significant association between the Apo... DisGeNET Detail
These results provide tentative evidence that APOE genotype moderates the association between high b... DisGeNET Detail
Apolipoprotein E, carbon dioxide vasoreactivity, and cognition in older adults: effect of hypertensi... DisGeNET Detail
Predictors of MCI were APOE ε4 allele (hazard ratio [HR] 1.89; p = 0.008), current depressive sympto... DisGeNET Detail
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Genetic association of apolipoprotein E polymorphisms with inflammatory bowel disease. DisGeNET Detail
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Our meta-analysis supports that the ApoE ε2 allele and ACACB rs2268388 C>T might act as promotion fa... DisGeNET Detail
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Association of apolipoprotein E gene polymorphism with end-stage renal disease and hyperlipidemia in... DisGeNET Detail
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The role of apolipoprotein E as a risk factor for an earlier age at onset for Machado-Joseph disease... DisGeNET Detail
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Meta-analysis of apolipoprotein E gene polymorphism and susceptibility of myocardial infarction. DisGeNET Detail
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Secretomes are a potential source of molecular targets for cancer therapies and indicate that APOE i... DisGeNET Detail
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Among PD patients without dementia, the APOE ε4 allele was only associated with lower performance on... DisGeNET Detail
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Increased cholesterol biosynthesis, elevated PCSK9 levels and reduced APOE mRNA expression newly fou... DisGeNET Detail
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In each case, a single gene is represented in a plurality of epistatic interactions, apolipoprotein ... DisGeNET Detail
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The KLC1 and APOE genes may be novel susceptibility genes for age-related cataracts. DisGeNET Detail
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The Number of Cysteine Residues per Mole in Apolipoprotein E Is Associated With the Severity of PTSD... DisGeNET Detail
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The data about apolipoprotein E gene (APOE) genotype and the risk of stroke are inconsistent. DisGeNET Detail
Association of the ApoE gene polymorphism and dietary factors with cerebral infarction and circulati... DisGeNET Detail
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Analyses also considered APOE genotype and tremor- vs. rigidity-dominant phenotype. DisGeNET Detail
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Influence of APOE-2 genotype on the relation between adiposity and plasma lipid levels in patients w... DisGeNET Detail
APOE genotype was significantly associated with performance on several different tests of cognitive ... DisGeNET Detail
Predictors of MCI were APOE ε4 allele (hazard ratio [HR] 1.89; p = 0.008), current depressive sympto... DisGeNET Detail
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Apolipoprotein E and protection against hepatitis E viral infection in American non-Hispanic blacks. DisGeNET Detail
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To gain insight into different cerebral amyloid angiopathy (CAA) phenotypes and mechanisms, we inves... DisGeNET Detail
APOE ε4 is associated with recurrent ICH in nonlobar brain regions, providing further evidence for i... DisGeNET Detail
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Apolipoprotein E and protection against hepatitis E viral infection in American non-Hispanic blacks. DisGeNET Detail
APOE [Latin Small Letter Open E]4 is a major risk factor for late-onset Alzheimer disease, a progres... DisGeNET Detail
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Reduced brain-derived neurotrophic factor (BDNF) signaling is considered as a pathogenic event in ea... DisGeNET Detail
There was a synergistic interaction between depression or apathy and APOE ε4 in further elevating th... DisGeNET Detail
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Predictors of MCI were APOE ε4 allele (hazard ratio [HR] 1.89; p = 0.008), current depressive sympto... DisGeNET Detail
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APOE ɛ4 was associated with atrophic hippocampal volume in MRI markers, increased cerebral amyloid d... DisGeNET Detail
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Secretoneurin gene therapy improves hind limb and cardiac ischaemia in Apo E⁻/⁻ mice without influen... DisGeNET Detail
Synthetic gestagens exert differential effects on arterial thrombosis and aortic gene expression in ... DisGeNET Detail
Secretomes are a potential source of molecular targets for cancer therapies and indicate that APOE i... DisGeNET Detail
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No renal phenotype in human phospholipid transfer protein transgenic apolipoprotein E deficient mice... DisGeNET Detail
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Seven patients had high levels of PrP, low Aβ42, high APOE-4, and 40% nerve cell loss, suggesting th... DisGeNET Detail
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The apolipoprotein E ε4 (ApoE ε4) allele not only represents the strongest single genetic risk facto... DisGeNET Detail
Compared with the stable memory trajectory, high Αβ (relative risk ratio [RRR] = 2.1), and lower Min... DisGeNET Detail
In conclusion, behavioural Alzheimer's disease presentations are characterized by a milder and more ... DisGeNET Detail
We measured RA, anterograde amnesia (AA), brain measures, apolipoprotein-E status (ApoE), and conver... DisGeNET Detail
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It was therefore investigated whether the association between load of WMHs and brain atrophy measure... DisGeNET Detail
This study evaluates the individual, as well as relative and joint value of indices obtained from ma... DisGeNET Detail
Genetic interaction of PICALM and APOE is associated with brain atrophy and cognitive impairment in ... DisGeNET Detail
Only 1 FTD patient (homozygous for apolipoprotein E ε4) displayed high cortical (18)F-florbetapir re... DisGeNET Detail
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Perhaps less well known, and certainly less well characterized, is that this ϵ4 variant of the APOE ... DisGeNET Detail
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A lower EF performance in cognitively intact older APOE ε4 allele carriers might be related to an ea... DisGeNET Detail
APOE gene polymorphism and risk of coronary stenosis in Pakistani population. DisGeNET Detail
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APOE ε4 influences β-amyloid deposition in primary progressive aphasia and speech apraxia. DisGeNET Detail
Osteoprotegerin deficiency limits angiotensin II-induced aortic dilatation and rupture in the apolip... DisGeNET Detail
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Apolipoprotein E gene polymorphisms in relation to chronic periodontitis, periodontopathic bacteria,... DisGeNET Detail
We report the association between ApoE 4 homozygous genotype and self-reported oropharyngeal dysphag... DisGeNET Detail
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Polymorphisms in the APOE gene and the location of retinal fluid in eyes with neovascular age-relate... DisGeNET Detail
To study whether presenilin 1 (PSEN1), apolipoprotein E (APOE), and kinesin light chain 1 (KLC1) gen... DisGeNET Detail
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APOE ε4 influences β-amyloid deposition in primary progressive aphasia and speech apraxia. DisGeNET Detail
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APOE [Latin Small Letter Open E]4 is a major risk factor for late-onset Alzheimer disease, a progres... DisGeNET Detail
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Only 1 FTD patient (homozygous for apolipoprotein E ε4) displayed high cortical (18)F-florbetapir re... DisGeNET Detail
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In linear mixed models, controlling for age, gender, education, and apolipoprotein E status, subject... DisGeNET Detail
Apolipoprotein E (ApoE) is the most well-described genetic risk factor for Alzheimer's disease and n... DisGeNET Detail
Genetic interaction of PICALM and APOE is associated with brain atrophy and cognitive impairment in ... DisGeNET Detail
The alternative prodrome hypothesis predicts that the APOE-ε4 allele would be associated with longit... DisGeNET Detail
The combined effects of metabolic syndrome and the apolipoprotein E and CYP46 genotypes on the risk ... DisGeNET Detail
Age, APOE ε4, and decline in intellectually and socially stimulating recreational activity from mid ... DisGeNET Detail
Hypertension moderated the effects of APOE ε4 on the rate of change for cognitive flexibility, such ... DisGeNET Detail
Deploying a between-sibling design that allows quasi-experimental variation in genotype and educatio... DisGeNET Detail
Moreover, the interaction of APOE by age on brain morphology may accelerate the pathological progres... DisGeNET Detail
Fatty acid metabolism in carriers of apolipoprotein E epsilon 4 allele: is it contributing to higher... DisGeNET Detail
APOE genotype, along with other biomarkers, may be used in the future to assist nurses in identifyin... DisGeNET Detail
Influence of socio-demographic features and apolipoprotein E epsilon 4 expression on the prevalence ... DisGeNET Detail
Higher UACR values were significantly associated with cognitive dysfunction in the general Korean po... DisGeNET Detail
Apolipoprotein E (ApoE) ε4 allele is a known genetic risk factor for AD, which not only predisposes ... DisGeNET Detail
APOE allele might play a role in the occurrence of cognitive impairment after mTBI. DisGeNET Detail
Although APOE ε4 carriers are at high risk for cognitive decline, our findings suggest possible inte... DisGeNET Detail
Interactive effect of APOE genotype and blood pressure on cognitive decline: the PATH through life s... DisGeNET Detail
Effects of vascular risk factors and APOE ε4 on white matter integrity and cognitive decline. DisGeNET Detail
The ε4 allele of apolipoprotein E (APOE ε4) is a well-established risk factor for Alzheimer's diseas... DisGeNET Detail
Among persons without dementia, the prevalence of cerebral amyloid pathology as determined by positr... DisGeNET Detail
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Analysis of the expression and polymorphism of APOE, HSP, BDNF, and GRIN2B genes associated with the... DisGeNET Detail
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Association of the apolipoprotein E 2 allele with concurrent occurrence of endometrial hyperplasia a... DisGeNET Detail
Apolipoprotein E epsilon 4 genotype and a physically active lifestyle in late life: analysis of gene... DisGeNET Detail
High apolipoprotein E in cerebrospinal fluid of patients with Lewy body disorders is associated with... DisGeNET Detail
The presence of apraxia in AD is related to dementia severity and APOE ε4. DisGeNET Detail
To explore apolipoprotein E gene variants distribution among the patients of Alzheimer's disease and... DisGeNET Detail
Results indicate that the relationship between sedentary time and CBF in the left hippocampus differ... DisGeNET Detail
The MCI subjects who developed dementia were more likely to carry at least one copy of the APOE ε4 a... DisGeNET Detail
Association of apolipoprotein E-e4 and dementia declines with age. DisGeNET Detail
The cluster-derived normal group had significantly fewer APOE ε4 carriers and fewer who progressed t... DisGeNET Detail
Apolipoprotein E ε4 (APOE ε4) is a risk factor for β-amyloid deposition in Alzheimer's disease demen... DisGeNET Detail
The levels of miR‑193b, exosomal miR‑193b, Aβ, tau, p‑tau, HCY and APOE in samples from APP/PS1 doub... DisGeNET Detail
Cognitively healthy NDFAM showed a higher net cognitive gain after CS, as reflected in their MoCA sc... DisGeNET Detail
Increased WMH volume was associated with increased frequency of dementia irrespective of APOE ε4 sta... DisGeNET Detail
We assessed relative telomere length and apolipoprotein E genotype in subjects with dementia (n=70) ... DisGeNET Detail
Influence of socio-demographic features and apolipoprotein E epsilon 4 expression on the prevalence ... DisGeNET Detail
We included 209 consecutive late-onset AD patients to find out which factors among educational level... DisGeNET Detail
Apolipoprotein E (APOE) ε4 is an established risk factor for cognitive decline and the development o... DisGeNET Detail
Mediation analysis was used to estimate the direct and indirect effects of APOE alleles on AD pathol... DisGeNET Detail
There was a synergistic interaction between depression or apathy and APOE ε4 in further elevating th... DisGeNET Detail
This article considers APOE ϵ4 effects on cognition in people without dementia, the extent to which ... DisGeNET Detail
The allele frequency of APOE ε4 varies both across and within populations, and the size of the effec... DisGeNET Detail
Subgroup analyses indicated that (1) the significantly increased risk of AD from current smoking was... DisGeNET Detail
We have also established novel methods to express apoE isoforms in mouse brain to study apoE-related... DisGeNET Detail
Among persons without dementia, the prevalence of cerebral amyloid pathology as determined by positr... DisGeNET Detail
These findings indicate the potential clinical utility of amyloid imaging for differential diagnosis... DisGeNET Detail
Eleven patients with dementia had apolipoprotein E 4 (ApoE4) and R47H genotypes. DisGeNET Detail
Interaction of Apolipoprotein E Genotypes, Lifestyle Factors and Future Risk of Dementia-Related Mor... DisGeNET Detail
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The relationship between obstructive sleep apnea syndrome and apolipoprotein E genetic variants. DisGeNET Detail
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APOE [Latin Small Letter Open E]4 is a major risk factor for late-onset Alzheimer disease, a progres... DisGeNET Detail
We included 210 consecutive patients with late-onset AD to investigate whether education, gender, na... DisGeNET Detail
In this regard, the GHRH-GH-IGF-1/Insulin, TOR-S6K1,NAD(+)-Sirtuin, P53, Klotho and APOE pathways ha... DisGeNET Detail
Here we focused on long-living participants of the Long Life Family Study (LLFS), their offspring, a... DisGeNET Detail
PCSK9, apolipoprotein E and lipoviral particles in chronic hepatitis C genotype 3: evidence for geno... DisGeNET Detail
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Mean expression of APOE and TOMM40 mRNA levels were higher in VL homozygotes compared with S homozyg... DisGeNET Detail
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The aim of this study was to investigate the role of serotonin in depression, searching for associat... DisGeNET Detail
The aim of this study was to investigate the role of serotonin in depression, searching for associat... DisGeNET Detail
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The aim of this study was to investigate the role of serotonin in depression, searching for associat... DisGeNET Detail
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Longitudinal assessment of cognitive changes associated with adjuvant treatment for breast cancer: t... DisGeNET Detail
APOE genotype, along with other biomarkers, may be used in the future to assist nurses in identifyin... DisGeNET Detail
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Our study indicates that APOE is a potential indicator of metastatic lung ADC and that secretomes ma... DisGeNET Detail
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Apolipoprotein E gene polymorphisms are associated with primary hyperuricemia in a Chinese populatio... DisGeNET Detail
The altered binding to lipids and receptors by ApoE isoforms E2 and E4 results in an elevated risk f... DisGeNET Detail
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None of these patients had pathogenic mutations, APOE ε4 or other high-risk alleles associated with ... DisGeNET Detail
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We evaluated whether and to what extent the APOE genotype modifies the relation between adiposity an... DisGeNET Detail
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In this review, we focus on the main genes that are epigenetically modified during the atherogenic p... DisGeNET Detail
Xyloketal B attenuates atherosclerotic plaque formation and endothelial dysfunction in apolipoprotei... DisGeNET Detail
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Apolipoprotein E polymorphisms and ischaemic stroke: a two-center Greek study. DisGeNET Detail
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Our findings demonstrate that higher TC levels are observed long before the clinical manifestation o... DisGeNET Detail
Our findings suggest that SPARE-AD and ADAS-Cog in combination offer the highest predictive power of... DisGeNET Detail
Using Hotelling's T(2) test, we found significant morphological deformation in APOE e4 carriers rela... DisGeNET Detail
Participants were 74 patients with clinically confirmed aMCI (33 APOE ε4 noncarriers, 26 heterozygou... DisGeNET Detail
At baseline, older age, APOE-ε4 carriership, lower total cholesterol levels, and stroke were associa... DisGeNET Detail
The analyses were performed in the MCI population and subpopulations enriched by apolipoprotein E4 (... DisGeNET Detail
We measured RA, anterograde amnesia (AA), brain measures, apolipoprotein-E status (ApoE), and conver... DisGeNET Detail
Source analysis of spontaneous magnetoencephalograpic activity in healthy aging and mild cognitive i... DisGeNET Detail
The interaction of APOE genotype by age in amnestic mild cognitive impairment: a voxel-based morphom... DisGeNET Detail
Posterior cingulate γ-aminobutyric acid and glutamate/glutamine are reduced in amnestic mild cogniti... DisGeNET Detail
Only APOE-inclusive risk scores associated with worse memory and incident MCI/LOAD. DisGeNET Detail
Influence of the APOE ε4 allele and mild cognitive impairment diagnosis in the disruption of the MEG... DisGeNET Detail
APOE and mild cognitive impairment: the Framingham Heart Study. DisGeNET Detail
Combining serum and urine biomarkers in the early diagnosis of mild cognitive impairment that evolve... DisGeNET Detail
We used whole-exome sequencing to identify variants other than APOE associated with the rate of hipp... DisGeNET Detail
To investigate the population-based interaction between a biological variable (APOE ε4), neuropsychi... DisGeNET Detail
Five top susceptible single nucleotide polymorphisms (SNPs) in three loci in ZNF827, KDM2B and NANP ... DisGeNET Detail
Predictors of MCI were APOE ε4 allele (hazard ratio [HR] 1.89; p = 0.008), current depressive sympto... DisGeNET Detail
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Longitudinal assessment of cognitive changes associated with adjuvant treatment for breast cancer: t... DisGeNET Detail
We stratified all analyses by race.Using the Modified Mini-Mental State Examination scores, we asses... DisGeNET Detail
General linear mixed-effects models were used to investigate the relationship between baseline cereb... DisGeNET Detail
Overall, our results point to education as a protective factor that may help to postpone cognitive c... DisGeNET Detail
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Immunohistochemistry was quantified for Aβ42, apoE, apoE E4 and smooth muscle actin, and CAA-associa... DisGeNET Detail
Among individuals with advanced CAA, cSS tends to occur in individuals with relatively lower CMB cou... DisGeNET Detail
This neuropathologically defined CAA cohort suggests that CSS and APOE ε2 are related to the hemorrh... DisGeNET Detail
Convexal subarachnoid hemorrhage presented an APOE-ɛ2 overrepresentation and CAAo had an APOE-ɛ4 ove... DisGeNET Detail
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The aim of this study was to investigate the expression of circulating microRNAs (miRNAs) in apolipo... DisGeNET Detail
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Association of apolipoprotein E gene polymorphism with end-stage renal disease and hyperlipidemia in... DisGeNET Detail
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Apolipoprotein e mutation and double filtration plasmapheresis therapy on a new Chinese patient with... DisGeNET Detail
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The interaction between PON1 genes (rs662 and rs85460) and ApoE genes showed synergistic epistasis i... DisGeNET Detail
Mitochondrial aldehyde dehydrogenase activation by Alda-1 inhibits atherosclerosis and attenuates he... DisGeNET Detail
The interaction between PON1 genes (rs662 and rs85460) and ApoE genes showed synergistic epistasis i... DisGeNET Detail
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Apolipoprotein E genotype and cognitive function in postmenopausal women with early-stage breast can... DisGeNET Detail
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Cognitive, neuropsychiatric, and motor features associated with apolipoprotein E ε4 allele in a samp... DisGeNET Detail
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We included 210 consecutive patients with late-onset AD to investigate whether education, gender, na... DisGeNET Detail
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Sixty per cent of patients with behavioural Alzheimer's disease and 40% of those with the dysexecuti... DisGeNET Detail
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This study assessed the roles of Tau gene short tandem repeats (STRs) nested within intron 1 (rs5820... DisGeNET Detail
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Mean expression of APOE and TOMM40 mRNA levels were higher in VL homozygotes compared with S homozyg... DisGeNET Detail
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We measured RA, anterograde amnesia (AA), brain measures, apolipoprotein-E status (ApoE), and conver... DisGeNET Detail
APOE ε4, the major genetic risk factor for late-onset AD, has been associated with smaller volume in... DisGeNET Detail
Lack of association between APOE gene polymorphisms and amyotrophic lateral sclerosis: a comprehensi... DisGeNET Detail
Treatment of adult microglia with apolipoprotein E suppressed the M0-homeostatic unique microglia si... DisGeNET Detail
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The presence of apraxia in AD is related to dementia severity and APOE ε4. DisGeNET Detail
Overexpression of CCN3 inhibits inflammation and progression of atherosclerosis in apolipoprotein E-... DisGeNET Detail
Apolipoprotein A1 (ApoA1) and apolipoprotein E (ApoE) mimetic peptides have attracted attention due ... DisGeNET Detail
The objective of this study was to investigate the effect of Lactobacillus acidophilus ATCC 4356 on ... DisGeNET Detail
Secretoneurin gene therapy improves hind limb and cardiac ischaemia in Apo E⁻/⁻ mice without influen... DisGeNET Detail
Finally, we studied the effect of 3BDO on oxLDL-altered PDI protein level in apolipoprotein E(-/-) m... DisGeNET Detail
The serum levels of atherosclerosis-related inflammatory factors in ApoE-/- mice were measured by mo... DisGeNET Detail
Here, we evaluated the contribution of CD39 to atherogenesis in the apolipoprotein E-deficient (ApoE... DisGeNET Detail
IRF2BP2-deficient macrophages worsened atherosclerosis in irradiated low-density lipoprotein recepto... DisGeNET Detail
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Overexpression of CCN3 inhibits inflammation and progression of atherosclerosis in apolipoprotein E-... DisGeNET Detail
Apolipoprotein A1 (ApoA1) and apolipoprotein E (ApoE) mimetic peptides have attracted attention due ... DisGeNET Detail
The objective of this study was to investigate the effect of Lactobacillus acidophilus ATCC 4356 on ... DisGeNET Detail
Secretoneurin gene therapy improves hind limb and cardiac ischaemia in Apo E⁻/⁻ mice without influen... DisGeNET Detail
Finally, we studied the effect of 3BDO on oxLDL-altered PDI protein level in apolipoprotein E(-/-) m... DisGeNET Detail
The serum levels of atherosclerosis-related inflammatory factors in ApoE-/- mice were measured by mo... DisGeNET Detail
Here, we evaluated the contribution of CD39 to atherogenesis in the apolipoprotein E-deficient (ApoE... DisGeNET Detail
IRF2BP2-deficient macrophages worsened atherosclerosis in irradiated low-density lipoprotein recepto... DisGeNET Detail
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The chi-square test and multivariable logistic regression analysis with adjustment for covariates re... DisGeNET Detail
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Longitudinal assessment of cognitive changes associated with adjuvant treatment for breast cancer: t... DisGeNET Detail
APOE genotype, along with other biomarkers, may be used in the future to assist nurses in identifyin... DisGeNET Detail
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Overlapped Transcript Coordinates

Gene Transcript ID Exon Number Chromosome Start Stop Type Amino Mutation Transcript Position Links

Overlapped Transcript

Gene Transcript ID Chromosome Start Stop Links
Gene
-
dbSNP
rs10675722 dbSNP
Genome
hg19
Position
chr19:45,409,053-45,412,650
Variant Type
snv
Genome browser