frontotemporal dementia
Information
- Disease name
- frontotemporal dementia
- Disease ID
- DOID:9255
- Description
- "A dementia characterized by progressive neuronal loss predominantly involving the frontal and/or temporal lobes of the brain resulting in a gradual and progressive decline in behavior or language." [url:http\://en.wikipedia.org/wiki/Frontotemporal_dementia, url:http\://www.mayoclinic.org/diseases-conditions/frontotemporal-dementia/basics/definition/con-20023876, url:https\://www.ncbi.nlm.nih.gov/pubmed/21121521, url:https\://www.rarediseases.org/rare-disease-information/rare-diseases/byID/673/viewAbstract]
Disease area statistics
Chromosome band
| Gene symbol | Chromosome | Start | Stop | The number of variant |
|---|---|---|---|---|
| DOCK3 | 3 | 50,674,927 | 51,384,198 | 16 |
| DCC | 18 | 52,340,197 | 53,535,899 | 8 |
| ADAMTS2 | 5 | 179,110,853 | 179,345,461 | 6 |
| METTL16 | 17 | 2,416,049 | 2,511,888 | 4 |
| MAPT | 17 | 45,894,554 | 46,028,334 | 4 |
| ELAPOR1 | 1 | 109,114,115 | 109,206,781 | 4 |
| PPARGC1A | 4 | 23,792,021 | 23,890,047 | 4 |
| BCAS3 | 17 | 60,679,458 | 61,392,831 | 4 |
| IGF2BP2 | 3 | 185,643,975 | 185,825,012 | 4 |
| SGSM1 | 22 | 24,806,319 | 24,925,137 | 4 |
Annotation
| Genes | Mutation | Description | Source | Links |
|---|
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT05742698 | Active, not recruiting | Phase 2 | Nabilone for Agitation in Frontotemporal Dementia | March 7, 2023 | December 2025 |
| NCT03912987 | Active, not recruiting | TRIAL READY (Clinical Trial Readiness) | January 22, 2019 | June 2025 | |
| NCT05012410 | Active, not recruiting | N/A | WeCareAdvisor Study for Caregivers of People Living With Dementia | December 13, 2021 | October 2025 |
| NCT05669365 | Active, not recruiting | N/A | The Care Ecosystem Consortium Effectiveness Study | January 17, 2023 | December 31, 2025 |
| NCT03987295 | Active, not recruiting | Phase 2 | A Phase 2 Study to Evaluate Safety of Long-term AL001 Dosing in Frontotemporal Dementia (FTD) Patients (INFRONT-2) | September 27, 2019 | June 2, 2026 |
| NCT05315661 | Active, not recruiting | Phase 1 | The Safety and The Efficacy Evaluation of ET-STEM in Patients With Frontotemporal Dementia | July 6, 2022 | December 31, 2026 |
| NCT03260920 | Active, not recruiting | Phase 2 | Intranasal Oxytocin for Frontotemporal Dementia | January 31, 2018 | December 31, 2024 |
| NCT04993755 | Active, not recruiting | Phase 2 | A Phase 2a Study of TPN-101 in Patients With C9ORF72 ALS/FTD | October 1, 2021 | September 1, 2023 |
| NCT05842473 | Active, not recruiting | N/A | Long-term Effect of TMS in Primary Progressive Aphasia | February 1, 2023 | July 31, 2024 |
| NCT05075187 | Active, not recruiting | Epidemiological Study in FRONtoTemporal Dementia | September 1, 2021 | September 30, 2024 | |
| NCT04220021 | Active, not recruiting | Phase 2 | Safety and Therapeutic Potential of the FDA-approved Drug Metformin for C9orf72 ALS/FTD | January 10, 2020 | August 26, 2024 |
| NCT04374136 | Active, not recruiting | Phase 3 | A Phase 3 Study to Evaluate Efficacy and Safety of AL001 in Frontotemporal Dementia (INFRONT-3) | July 23, 2020 | October 11, 2027 |
| NCT04516499 | Active, not recruiting | Neurofilament Surveillance Project (NSP) | September 2, 2020 | December 2026 | |
| NCT06209515 | Active, not recruiting | Sociodemographic Factors and Criminal Behaviour Preceding Neurodegenerative Disease - Retrospective Register Study | January 1, 2022 | December 31, 2027 | |
| NCT04937452 | Active, not recruiting | Phase 2 | Dopaminergic Therapy for Frontotemporal Dementia Patients | June 3, 2021 | April 1, 2024 |
| NCT05262023 | Active, not recruiting | Phase 1/Phase 2 | A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of DNL593 in Healthy Participants and Participants With Frontotemporal Dementia (FTD-GRN) | February 1, 2022 | November 2025 |
| NCT05916664 | Completed | N/A | Efficacy Study of Kinto Care Coaching for Dementia Family Caregivers | May 18, 2023 | April 22, 2024 |
| NCT02819700 | Completed | Evaluation and Characterization of Behavioural Disorders and Dementias by the Behavioural Dysexecutive Syndrome Inventory (BDSI) | January 29, 2013 | January 28, 2018 | |
| NCT02860338 | Completed | COMPARATIVE EFFECTIVENESS OF MCI and DEMENTIA TREATMENTS IN A COMMUNITY-BASED DEMENTIA PRACTICE | January 2009 | December 2015 | |
| NCT02999282 | Completed | N/A | Rehabilitative Trial for the Rescue of Neurophysiological Parameters in Progranulin Deficient Subjects | October 31, 2016 | June 30, 2019 |
| NCT03040713 | Completed | Phase 1 | Flortaucipir PET Imaging in Subjects With FTD | April 11, 2017 | October 24, 2018 |
| NCT03076671 | Completed | N/A | More Than a Movement Disorder: Applying Palliative Care to Parkinson's Disease | March 1, 2017 | December 31, 2020 |
| NCT03088956 | Completed | Cognitive, Behavioral, and Functional Change in Behavioral Variant Frontotemporal Dementia (bvFTD) | January 19, 2018 | September 23, 2019 | |
| NCT05525377 | Completed | N/A | Better Living With Non-memory-led Dementia | June 21, 2022 | February 9, 2023 |
| NCT03510572 | Completed | Early Phase 1 | Evaluation of [18F]PI-2620 as a Potential Positron Emission Computed Tomography Radioligand for Imaging Tau Protein in the Brain | June 4, 2018 | July 31, 2019 |
| NCT03625128 | Completed | Early Phase 1 | 18F-PM-PBB3 PET Study in Tauopathy Including Alzheimer's Disease, Other Dementias and Normal Controls | January 2, 2018 | December 3, 2018 |
| NCT03636204 | Completed | Phase 1 | A First in Human Study in Healthy Volunteers and in Participants With Frontotemporal Dementia With Granulin (GRN) Mutation | September 14, 2018 | December 31, 2019 |
| NCT03682185 | Completed | Phase 3 | The Healthy Patterns Sleep Study | May 1, 2016 | May 31, 2021 |
| NCT03699644 | Completed | Multimodal Ocular Imaging in Neurodegeneration | January 4, 2019 | April 3, 2019 | |
| NCT03828383 | Completed | N/A | In-Home Technology for Dementia Caregivers | February 26, 2019 | November 27, 2020 |
| NCT03967535 | Completed | Connectomics in Psychiatric Classification | December 1, 2018 | September 5, 2019 | |
| NCT04104373 | Completed | The Ontario Neurodegenerative Disease Research Initiative | July 7, 2014 | April 30, 2018 | |
| NCT05508646 | Completed | N/A | Group-Based Telehealth Music Therapy Intervention for Patients With Dementia: A Pilot Study | January 1, 2023 | January 29, 2024 |
| NCT04157244 | Completed | N/A | The Music, Sleep and Dementia Study | March 12, 2019 | January 12, 2021 |
| NCT04165213 | Completed | N/A | Care of Persons With Dementia in Their Environments (COPE) in Programs of All-Inclusive Care of the Elderly (PACE) | June 28, 2021 | May 31, 2024 |
| NCT04413851 | Completed | Feasibility of Passive Data Collection in Dementia Subjects With Agitation | June 1, 2020 | December 6, 2021 | |
| NCT05444244 | Completed | N/A | A Relational Research Recruitment and Engagement Intervention for Cognitive Aging Research | August 1, 2022 | May 31, 2023 |
| NCT04489017 | Completed | Phase 2 | Palmitoylethanolamide Combined With Luteoline in Frontotemporal Dementia Patients. A Randomized Controlled Trial | June 1, 2019 | June 30, 2023 |
| NCT03923517 | Completed | N/A | RHAPSODY-plus: Online Counseling for Family Caregivers of Patients With Young Onset Dementia | January 1, 2018 | May 30, 2019 |
| NCT00376051 | Completed | Phase 4 | Serotonergic Function and Behavioural and Psychological Symptoms of Frontotemporal Dementia | September 2006 | September 2009 |
| NCT00416169 | Completed | Phase 2 | A Pilot Study to Explore the Safety and Tolerability of Galantamine HBr in the Treatment of Pick Complex/Frontotemporal Dementia | May 2003 | July 2004 |
| NCT00594737 | Completed | Phase 3 | Open Label Pilot Study of the Effects of Memantine on FDG-PET in Frontotemporal Dementia | October 2007 | June 2012 |
| NCT00938665 | Completed | Evaluation of a Handheld Event Related Potential (ERP)/Quantitative Electroencephalography (qEEG) System (COGNISION™) as a Useful Cognitive Biomarker for Alzheimer's Disease. | December 2010 | February 2014 | |
| NCT01002300 | Completed | N/A | Oxytocin and Social Cognition in Frontotemporal Dementia | September 2009 | November 2010 |
| NCT06354933 | Completed | Neurological Soft Signs in Neurodegenerative Dementias | April 1, 2022 | February 1, 2024 | |
| NCT01386333 | Completed | Phase 1 | Safety Study of Intranasal Oxytocin in Frontotemporal Dementia | June 2011 | |
| NCT01890343 | Completed | Phase 2 | Imaging Characteristics of Florbetapir 18F in Patients With Frontotemporal Dementia, Alzheimer's Disease and Normal Controls. | September 2009 | April 2013 |
| NCT01937013 | Completed | Phase 2 | Impact of Emotional Mimicry and Oxytocin on Frontotemporal Dementia | September 12, 2013 | December 21, 2017 |
| NCT02050464 | Completed | Computational Tools for Early Diagnosis of Memory Disorders | December 2013 | April 2017 | |
| NCT02055092 | Completed | Young Onset Dementia - the Difficult Diagnosis and the Stressful Life for the Whole Family | February 2014 | July 2020 | |
| NCT02236832 | Completed | N/A | Study of the Neural Basis of Analogical Reasoning | February 2015 | February 2021 |
| NCT02439853 | Completed | N/A | Communication Bridge Speech Therapy Research Study | March 2013 | January 2020 |
| NCT02496312 | Completed | N/A | Quantitative Evaluation of Apathy Close to Real Life Situation by Means of a Multimodal Sensor System Integrated. | July 10, 2015 | October 2, 2015 |
| NCT02506036 | Completed | N/A | Efficacy of Web-Based Social-Cognitive Interventions in Right Hemisphere Stroke and Frontotemporal Dementia | August 2015 | May 2017 |
| NCT05338710 | Completed | N/A | Support Via Technology: Living and Learning With Advancing FTD | January 14, 2021 | March 4, 2022 |
| NCT05019014 | Completed | Olfactory Deficits in Neurologic Disease | August 10, 2011 | July 3, 2020 | |
| NCT04939818 | Completed | Clinical Feasibility of Speech Phenotyping for Remote Assessment of Neurodegenerative and Psychiatric Disorders | June 14, 2021 | September 15, 2022 | |
| NCT04977245 | Completed | N/A | Mindfulness-Based Stress Reduction in Dementia Caregivers | August 12, 2021 | April 4, 2022 |
| NCT02327845 | Enrolling by invitation | Phenotype, Genotype & Biomarkers in ALS and Related Disorders | April 2015 | July 2025 | |
| NCT04961450 | Enrolling by invitation | Explore Biomarkers of Motor Neuron Disease/Frontal Dementia Spectrum Disease in China | June 24, 2021 | December 31, 2030 | |
| NCT06246019 | Enrolling by invitation | The Clinical Impact of the Novel Alzheimer's Blood-based Biomarkers | February 7, 2024 | December 31, 2025 | |
| NCT01459302 | Enrolling by invitation | Genetic Study of Familial and Sporadic ALS/Motor Neuron Disease, Miyoshi Myopathy and Other Neuromuscular Disorders | January 2009 | October 2024 | |
| NCT00950430 | Enrolling by invitation | Phase 4 | Imaging of Brain Amyloid Plaques in the Aging Population | April 2008 | June 2024 |
| NCT04060082 | Enrolling by invitation | Voices Of Individuals: Challenges and Experiences Of bvFTD | June 26, 2019 | December 2024 | |
| NCT05483322 | No longer available | An Open-Label, Expanded Access Protocol of LAM-002A in C9ORF72-Associated Frontotemporal Dementia (FTD) | |||
| NCT06377033 | Not yet recruiting | N/A | Using the EHR to Advance Genomic Medicine Across a Diverse Health System | May 1, 2024 | June 30, 2027 |
| NCT05956834 | Recruiting | A Multi-Modal Remote Monitoring Platform for Frontotemporal Lobar Degeneration (FTLD) Syndromes | July 28, 2023 | December 30, 2026 | |
| NCT01353430 | Recruiting | Characterization of Inclusion Body Myopathy Associated With Paget's Disease of Bone and Frontotemporal Dementia (IBMPFD) | November 15, 2007 | December 2026 | |
| NCT04875416 | Recruiting | Phenotype, Genotype and Biomarkers 2 | January 8, 2021 | August 2025 | |
| NCT06221202 | Recruiting | N/A | Stories in the Moment: Dance Program for People Living With Dementia | February 10, 2023 | October 31, 2024 |
| NCT04844060 | Recruiting | Cerebro Spinal Fluid Collection (CSF) | February 2010 | December 2030 | |
| NCT05288842 | Recruiting | Tanycytes in Alzheimer's Disease and Frontotemporal Dementia | September 6, 2022 | October 2026 | |
| NCT04747431 | Recruiting | Phase 1/Phase 2 | A Study of PBFT02 in Patients With Frontotemporal Dementia and Progranulin Mutations (FTD-GRN) | September 14, 2021 | August 2027 |
| NCT05326750 | Recruiting | N/A | Non-invasive Neurostimulation as a Tool for Diagnostics and Management for Neurodegenerative Diseases | November 21, 2022 | July 2032 |
| NCT04639622 | Recruiting | N/A | GENetic Fronto Temporal Dementia Initiative in Lille | April 23, 2019 | April 23, 2026 |
| NCT05374278 | Recruiting | Phase 1/Phase 2 | First-in-Human Evaluation of an Astrocytic Glutamate Transporter (EAAT2) PET Tracer in Dementia | November 2, 2021 | July 1, 2025 |
| NCT04425148 | Recruiting | N/A | Gamma-Induction in FrontoTemporal Dementia Trial | December 30, 2020 | December 2025 |
| NCT04408625 | Recruiting | Phase 1/Phase 2 | Phase 1/2 Clinical Trial of LY3884963 in Patients With Frontotemporal Dementia With Progranulin Mutations (FTD-GRN) | November 9, 2020 | August 31, 2029 |
| NCT06203106 | Recruiting | NYSCF Scientific Discovery Biobank | November 10, 2022 | November 10, 2045 | |
| NCT04114994 | Recruiting | Longitudinal Cognitive Assessment by BoCA | October 1, 2019 | October 1, 2029 | |
| NCT06093126 | Recruiting | Phase 4 | Lemborexant for Insomnia in a Patient With Dementia: An N-of-1 Trial | December 11, 2023 | December 11, 2028 |
| NCT05642351 | Recruiting | Autobiographical Specificity | February 3, 2023 | February 28, 2025 | |
| NCT03233646 | Recruiting | Retinal Imaging in Neurodegenerative Disease | July 20, 2017 | December 31, 2025 | |
| NCT05699330 | Recruiting | N/A | Subgenual Cingulate Deep Brain STIMulation for Apathetic Behavioral Variant FRONtotemporal Dementia | January 12, 2023 | January 12, 2026 |
| NCT03225144 | Recruiting | Investigating Complex Neurodegenerative Disorders Related to Amyotrophic Lateral Sclerosis and Frontotemporal Dementia | October 11, 2017 | October 30, 2025 | |
| NCT05779813 | Recruiting | Genetic Frontotemporal Dementia Initiative for Neurodevelopment | March 2023 | March 2035 | |
| NCT05779839 | Recruiting | N/A | A Study of Caregiver Connections Via Technology in Dementia | February 22, 2023 | December 2024 |
| NCT06064890 | Recruiting | Phase 1/Phase 2 | A Study to Evaluate the Safety and Effect of AVB-101, a Gene Therapy Product, in Subjects With a Genetic Sub-type of Frontotemporal Dementia (FTD-GRN) | August 30, 2023 | October 31, 2030 |
| NCT02945774 | Recruiting | N/A | Molecular Neuroimaging of Neuroinflammation in Neurodegenerative Dementias | August 2016 | August 2025 |
| NCT02795052 | Recruiting | N/A | Neurologic Stem Cell Treatment Study | June 2016 | July 31, 2026 |
| NCT00159198 | Terminated | Amyotrophic Lateral Sclerosis and Frontotemporal Dementia | September 2002 | June 2007 | |
| NCT05004558 | Unknown status | N/A | Effects of Remote-based Resistance Training on Cardiometabolic Risk Factors, Cognitive Function, and Quality of Life in Adults Living With Alzheimer's Disease and/or Related Dementias | September 1, 2021 | June 2022 |
| NCT03272230 | Unknown status | N/A | Assessment of Apathy in a Real-life Situation, With a Video and Sensors-based System | September 6, 2017 | February 28, 2022 |
| NCT05260151 | Unknown status | Tau Protein and SV2a Imaging in Patients With Tau Protein-related Diseases | November 18, 2020 | December 31, 2022 | |
| NCT04918251 | Unknown status | EEG and TMS-based Biomarkers of ALS, MS and FTD | September 2012 | April 2023 | |
| NCT01147679 | Unknown status | Study of Social Behavior and Emotion in Frontotemporal Dementia, Alzheimer's Disease and Controls | January 2010 | July 2014 | |
| NCT05497817 | Withdrawn | N/A | A Study to Evaluate Caregiver Connections Via Technology for Patients With Alzheimer's and Other Types of Dementia | September 2022 | December 2024 |
| NCT01615666 | Withdrawn | A Composite MR Neuroimaging Marker for Alzheimer's Disease | March 2009 | January 2016 | |
| NCT05830214 | Withdrawn | Digital Smartwatch Measurements as Potential Biomarkers for Remote Disease Tracking in ALS | January 2024 | February 6, 2024 |
- Disase is a (Disease Ontology)
- DOID:1307
- Cross Reference ID (Disease Ontology)
- GARD:8436
- Cross Reference ID (Disease Ontology)
- MESH:C563003
- Cross Reference ID (Disease Ontology)
- MIM:600274
- Cross Reference ID (Disease Ontology)
- ORDO:282
- Cross Reference ID (Disease Ontology)
- SNOMEDCT_US_2023_03_01:42369001
- Cross Reference ID (Disease Ontology)
- UMLS_CUI:C0520716
- Exact Synonym (Disease Ontology)
- frontotemporal lobar degeneration
- Exact Synonym (Disease Ontology)
- multiple system tauopathy with presenile dementia
- Exact Synonym (Disease Ontology)
- pallidopontonigral degeneration
- Exact Synonym (Disease Ontology)
- Wilhemsen-Lynch disease
- HPO Human Phenotype ID (Human Phenotype Ontology)
- HP:0002145
- OrphaNumber from OrphaNet (Orphanet)
- 282
- MedGen concept unique identifier (MedGen Concept name)
- C0338451
- MedGen unique identifier (MedGen Concept name)
- 83266
- MeSH unique ID (MeSH (Medical Subject Headings))
- D057180