hypoplastic left heart syndrome
Information
- Disease name
- hypoplastic left heart syndrome
- Disease ID
- DOID:9955
- Description
- "A congenital heart disease characterized by abnormal development of the left-sided structures of the heart." [url:http\://en.wikipedia.org/wiki/Hypoplastic_left_heart_syndrome, url:http\://rarediseases.info.nih.gov/gard/6739/hypoplastic-left-heart-syndrome/resources/1, url:http\://www.merckmanuals.com/professional/pediatrics/congenital_cardiovascular_anomalies/hypoplastic_left_heart_syndrome.html]
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
| Genes | Mutation | Description | Source | Links |
|---|
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT03079401 | Active, not recruiting | Phase 1/Phase 2 | Mesoblast Stem Cell Therapy for Patients With Single Ventricle and Borderline Left Ventricle | November 27, 2017 | January 2024 |
| NCT02919956 | Active, not recruiting | Cerebral Anatomy, Hemodynamics and Metabolism | April 2016 | June 30, 2025 | |
| NCT03779711 | Active, not recruiting | Phase 2 | Intramyocardial Injection of Autologous Umbilical Cord Blood Derived Mononuclear Cells During Surgical Repair of Hypoplastic Left Heart Syndrome | June 6, 2019 | February 2026 |
| NCT00507819 | Completed | Phase 2 | Sildenafil After the Fontan Operation | December 2007 | July 2009 |
| NCT00513240 | Completed | Phase 1/Phase 2 | Erythropoetin Neuroprotection for Neonatal Cardiac Surgery | September 2006 | September 2015 |
| NCT00571233 | Completed | Biomarker Study for Heart Failure in Children With Single Ventricle Physiology | February 2007 | January 2015 | |
| NCT00734643 | Completed | Family Adaptation Study Following the Diagnosis of Hypoplastic Left Heart Syndrome in a Newborn | June 2006 | September 5, 2019 | |
| NCT00974025 | Completed | N/A | Impact of Vitamin C on Endothelial Function and Exercise Capacity in Fontan-Palliated Patients | June 2009 | March 2010 |
| NCT01032876 | Completed | N/A | Cerebral Perfusion During Neonatal Cardiac Surgery | January 2009 | June 2012 |
| NCT01215240 | Completed | N/A | Prophylactic Peritoneal Dialysis Decreases Time to Achieve a Negative Fluid Balance After the Norwood Procedure | September 2010 | December 2013 |
| NCT01273857 | Completed | Phase 1 | Transcoronary Infusion of Cardiac Progenitor Cells in Patients With Single Ventricle Physiology | January 2011 | January 2013 |
| NCT01292551 | Completed | Phase 2 | Study of Placebo or Bosentan to Treat Patients With Single Ventricle Physiology. | February 2011 | March 2013 |
| NCT04452188 | Completed | N/A | Targeting Normoxia in Neonates With Cyanotic Congenital Heart Disease in the Intra-operative and Immediate Post-operative Period | January 18, 2021 | April 20, 2023 |
| NCT03136835 | Completed | Phase 1/Phase 2 | Maternal Hyperoxygenation in Congenital Heart Disease | February 2, 2018 | March 22, 2024 |
| NCT01656941 | Completed | Genetic Determinants of Congenital Heart Disease Outcomes | March 2011 | March 16, 2017 | |
| NCT01708863 | Completed | A Prospective Study of Patients With Hypoplastic Left Heart Syndrome (HLHS) Following Stage II Surgical Palliation | October 2012 | May 15, 2020 | |
| NCT01736956 | Completed | N/A | Fetal Intervention for Aortic Stenosis and Evolving Hypoplastic Left Heart Syndrome | October 2012 | October 2022 |
| NCT01829750 | Completed | Phase 2 | Cardiac Progenitor Cell Infusion to Treat Univentricular Heart Disease (PERSEUS) | April 2013 | September 2016 |
| NCT01883076 | Completed | Phase 1 | Safety Study of Autologous Umbilical Cord Blood Cells for Treatment of Hypoplastic Left Heart Syndrome | May 15, 2013 | April 28, 2021 |
| NCT02080637 | Completed | Phase 2 | Ambrisentan in Single Ventricle | July 2015 | August 20, 2017 |
| NCT02184169 | Completed | N/A | Oxygen Consumption-based Assessments of Hemodynamics in Neonates Following Congenital Heart Surgery (Oxy-CAHN Study) | December 2012 | January 29, 2019 |
| NCT02306057 | Completed | Fluid Balance in Children Undergoing Fontan Surgery | November 2014 | April 2017 | |
| NCT04056416 | Completed | N/A | Physical Activity Promotion in Children and Adolescents With Single Ventricle Physiology (MedBike) | March 25, 2019 | November 9, 2022 |
| NCT02462434 | Completed | N/A | Impact of Early Intervention on Maternal Stress in Mothers of Fetuses Diagnosed With Single Ventricle Physiology | April 2013 | November 15, 2016 |
| NCT02657629 | Completed | N/A | Comparison of Feeding Strategies for Hypoplastic Left Heart Syndrome Infants | December 2009 | November 2012 |
| NCT00308217 | Completed | Single Ventricle Outcome | June 2005 | June 2005 | |
| NCT01582529 | Completed | SVRII Family Factors Study | June 2012 | November 14, 2019 | |
| NCT03431480 | Completed | Phase 1 | Safety of Autologous Cord Blood Cells in HLHS Patients During Norwood Heart Surgery | February 16, 2018 | June 30, 2022 |
| NCT00464100 | Completed | Near-infrared Spectroscopy (NIRS) Neurodevelopmental Outcomes | March 1, 2006 | December 4, 2013 | |
| NCT06342999 | Not yet recruiting | N/A | Fetal Aortic Valvuloplasty for Evolving Hypoplastic Left Heart Syndrome | July 2024 | July 2035 |
| NCT06461676 | Not yet recruiting | Phase 1 | Study of Intramyocardial Injection of Ventrix Bio Extracellular Matrix (VentriGel) to Assess the Safety and Feasibility in Pediatric Patients With Hypoplastic Left Heart Syndrome (HLHS) | October 1, 2024 | September 30, 2027 |
| NCT04581668 | Recruiting | N/A | Impact of NAVA Ventilation on Brain Oxygenation and Perfusion in Children With Congenital Heart Disease | October 5, 2020 | December 1, 2023 |
| NCT02781922 | Recruiting | Phase 3 | Cardiac Stem/Progenitor Cell Infusion in Univentricular Physiology (APOLLON Trial) | June 2016 | May 2023 |
| NCT03406884 | Recruiting | Phase 1 | The CHILD Trial: Hypoplastic Left Heart Syndrome Study. | October 16, 2019 | July 2025 |
| NCT04925024 | Recruiting | Phase 2 | Evaluation of Lomecel-B™ Injection in Patients With Hypoplastic Left Heart Syndrome (HLHS): A Phase IIb Clinical Trial. | June 25, 2021 | August 2025 |
| NCT05386173 | Recruiting | Effect of Fetal Aortic Valvuloplasty on Outcomes | January 1, 2021 | December 31, 2029 | |
| NCT05709275 | Recruiting | Hypoplastic Left Heart Syndrome: Subendocardial Viability After Norwood Palliation | July 28, 2022 | July 28, 2027 | |
| NCT02398604 | Terminated | Phase 1 | Allogeneic hMSC Injection in Patients With Hypoplastic Left Heart Syndrome | April 2015 | March 2019 |
| NCT04181255 | Terminated | Phase 1 | Cold Heart Study: A Randomized Pilot Trial of Surfactant Therapy | February 25, 2020 | June 12, 2020 |
| NCT01445041 | Terminated | Phase 1 | Safety and Feasibility Study of Umbilical Cord Blood Cells for Infants With Hypoplastic Left Heart Syndrome | September 1, 2011 | April 15, 2016 |
| NCT00860327 | Terminated | Examining Developmental Changes in Heart Contractions of Children With Congenital Heart Defects | December 2007 | June 2016 | |
| NCT01107990 | Terminated | Global and Regional Myocardial Strain and Power Output In Patients With Single Ventricles Using Novel MRI Techniques | November 2009 | September 20, 2012 | |
| NCT03147014 | Unknown status | N/A | Cardiovascular Response to Maternal Hyperoxygenation in Fetal Congenital Heart Disease | January 1, 2016 | December 31, 2022 |
| NCT02455713 | Withdrawn | Positive Pressure Ventilation and Sternal Closure in HLHS | February 2015 | June 2017 | |
| NCT00156455 | Withdrawn | Sleep Disordered Breathing in Children With Single Ventricle Physiology | September 2004 | ||
| NCT03690245 | Withdrawn | N/A | Initiation of Resuscitation While Attached to the Cord With Congenital Heart Disease | December 18, 2018 | December 31, 2020 |
- Disase is a (Disease Ontology)
- DOID:1682
- Cross Reference ID (Disease Ontology)
- GARD:6739
- Cross Reference ID (Disease Ontology)
- ICD10CM:Q23.4
- Cross Reference ID (Disease Ontology)
- ICD9CM:746.7
- Cross Reference ID (Disease Ontology)
- MESH:D018636
- Cross Reference ID (Disease Ontology)
- MIM:241550
- Cross Reference ID (Disease Ontology)
- MIM:614435
- Cross Reference ID (Disease Ontology)
- NCI:C98894
- Cross Reference ID (Disease Ontology)
- ORDO:2248
- Cross Reference ID (Disease Ontology)
- SNOMEDCT_US_2023_03_01:62067003
- Cross Reference ID (Disease Ontology)
- UMLS_CUI:C0152101
- OMIM Phenotype Series Number (OMIM)
- PS241550
- OrphaNumber from OrphaNet (Orphanet)
- 2248
- MedGen concept unique identifier (MedGen Concept name)
- C0152101
- MedGen unique identifier (MedGen Concept name)
- 57746
- ICD10 preferred id (Insert disease from ICD10)
- D0013674
- ICD10 class code (Insert disease from ICD10)
- Q23.4
- MeSH unique ID (MeSH (Medical Subject Headings))
- D018636