chr9:117704175:> Detail (hg38)
Information
Genome
| Assembly | Position |
|---|---|
| hg19 | chr9:120,466,453-120,487,013 |
| hg38 | chr9:117,704,175-117,724,735 |
HGVS
| Type | Transcript | Protein |
|---|---|---|
Summary
MGeND
| Clinical significance | |
| Variant entry | |
| GWAS entry | |
| Disease area statistics | Show details |
Frequency
[No Data.]
Prediction
[No Data.]
ClinVar
| Clinical Significance | |
| Review star | [No Data.] |
| Show details | |
Links
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
[No Data.]
CIViC
[No Data.]
DisGeNET
| Score | Disease name | Description | Source | Pubmed | Links |
|---|---|---|---|---|---|
| 0.001 | squamous cell carcinoma | NA | BeFree | Detail | |
| <0.001 | Cardiomyopathy, Dilated | NA | BeFree | Detail | |
| 0.012 | Cardiovascular Diseases | NA | BeFree,GAD,LHGDN | Detail | |
| 0.002 | Carotid Artery Diseases | NA | GAD | Detail | |
| 0.080 | carotid stenosis | NA | RGD | Detail | |
| 0.009 | celiac disease | NA | BeFree,GAD,LHGDN | Detail | |
| 0.002 | cellulitis | NA | GAD | Detail | |
| 0.003 | brain ischemia | NA | BeFree,GAD | Detail | |
| <0.001 | Transient ischemic attack | NA | BeFree | Detail | |
| 0.005 | cerebral palsy | NA | GAD | Detail | |
| 0.001 | Malignant tumor of cervix | Cancer-derived immunoglobulin G promotes LPS-induced proinflammatory cytokine pr... | BeFree | 25179302 | Detail |
| 0.001 | Malignant tumor of cervix | However, the C/C genotype for the TLR3 (c.1377 C>T) polymorphism and the Asp/Asp... | BeFree | 25373689 | Detail |
| 0.005 | Chagas Cardiomyopathy | NA | BeFree,GAD | Detail | |
| <0.001 | Chediak-Higashi syndrome | For the first time, results from our study indicate defective trafficking of TLR... | BeFree | 25528552 | Detail |
| 0.006 | Chlamydia Infections | NA | BeFree,GAD,LHGDN | Detail | |
| 0.001 | Primary biliary cirrhosis | NA | BeFree | Detail | |
| <0.001 | Cholangitis, Sclerosing | NA | BeFree | Detail | |
| <0.001 | cholelithiasis | NA | BeFree | Detail | |
| <0.001 | cholesteatoma | Microarray analysis showed significant upregulation for NOD2, not for NOD1, TLR2... | BeFree | 25922834 | Detail |
| 0.007 | chorioamnionitis | NA | GAD,LHGDN | Detail | |
| <0.001 | hemophilia B | Immune responses to human factor IX in haemophilia B mice of different genetic b... | BeFree | 25417755 | Detail |
| <0.001 | Chronic osteomyelitis | NA | BeFree | Detail | |
| 0.084 | colitis | In this study, we investigated the involvement of NO production in activation of... | BeFree,RGD | 24992835 | Detail |
| <0.001 | Colonic Diseases | NA | BeFree | Detail | |
| 0.004 | colorectal carcinoma | Association between Toll-like receptor 4 and interleukin 17 gene polymorphisms a... | BeFree | 25216863 | Detail |
| 0.004 | colorectal carcinoma | Polymorphisms in NFKB1 and TLR4 and interaction with dietary and life style fact... | BeFree | 25705893 | Detail |
| 0.131 | Colorectal Neoplasms | NA | CTD_human,LHGDN | Detail | |
| <0.001 | common variable immunodeficiency | NA | BeFree | Detail | |
| 0.002 | Connective Tissue Diseases | NA | GAD | Detail | |
| 0.010 | Coronary Arteriosclerosis | The expression of TLR4 and TLR3 closely correlated with the severity of coronary... | BeFree,GAD | 24146036 | Detail |
| 0.010 | Coronary Arteriosclerosis | Activation of liver X receptor improves viability of adipose-derived mesenchymal... | BeFree,GAD | 24915051 | Detail |
| 0.010 | Coronary Arteriosclerosis | Circulating Toll-like receptor 4-responsive microRNA panel in patients with coro... | BeFree,GAD | 25385173 | Detail |
| 0.010 | Coronary Arteriosclerosis | The effect of genetic polymorphisms of TLR2 and TLR4 in Turkish patients with co... | BeFree,GAD | 25542811 | Detail |
| 0.008 | Coronary heart disease | The expression of TLR4 and TLR3 closely correlated with the severity of coronary... | BeFree,GAD | 24146036 | Detail |
| 0.008 | Coronary heart disease | Circulating Toll-like receptor 4-responsive microRNA panel in patients with coro... | BeFree,GAD | 25385173 | Detail |
| 0.008 | Coronary heart disease | The effect of genetic polymorphisms of TLR2 and TLR4 in Turkish patients with co... | BeFree,GAD | 25542811 | Detail |
| 0.002 | Cross Infection | NA | GAD | Detail | |
| 0.004 | cystic fibrosis | NA | BeFree,GAD | Detail | |
| 0.002 | cystitis | NA | GAD | Detail | |
| <0.001 | Dengue Fever | NA | BeFree | Detail | |
| <0.001 | dental caries | NA | BeFree | Detail | |
| <0.001 | depressive disorder | TLR2 and TLR4 risk genotype carrier state and history of childhood emotional, ph... | BeFree | 25790282 | Detail |
| <0.001 | dermatitis | NA | BeFree | Detail | |
| 0.008 | Dermatitis, Atopic | NA | BeFree,GAD | Detail | |
| 0.120 | contact dermatitis | NA | CTD_human | Detail | |
| <0.001 | dermatomyositis | TLR4 and TLR3, two potent inducers of autophagy, were highly increased in IIM, w... | BeFree | 25365350 | Detail |
| <0.001 | scleroderma | NA | BeFree | Detail | |
| 0.002 | Diabetes | NA | BeFree | Detail | |
| 0.004 | diabetes mellitus | NA | BeFree,GAD | Detail | |
| 0.080 | Diabetes Mellitus, Experimental | NA | RGD | Detail | |
| 0.012 | Diabetes Mellitus, Insulin-Dependent | NA | BeFree,GAD,LHGDN | Detail | |
| 0.001 | Diabetic Nephropathy | Enhanced glomerular Toll-like receptor 4 expression and signaling in patients wi... | BeFree | 24786705 | Detail |
| 0.001 | Diabetic Nephropathy | Our study suggests that curcumin treatment ameliorates DN via inhibition of infl... | BeFree | 25196431 | Detail |
| 0.203 | Diabetic Neuropathies | NA | BeFree,CTD_human,LHGDN,RGD | Detail | |
| 0.001 | diabetic retinopathy | Collectively, our novel data suggest that hyperglycemia induces TLR-2 and TLR-4 ... | BeFree | 25610879 | Detail |
| 0.001 | diabetic retinopathy | The association between toll-like receptor 4 polymorphisms and diabetic retinopa... | BeFree | 25947554 | Detail |
| <0.001 | Muscular Dystrophy, Duchenne | Toll-like receptor 4 ablation in mdx mice reveals innate immunity as a therapeut... | BeFree | 25552658 | Detail |
| 0.006 | duodenal ulcer | NA | BeFree,GAD | Detail | |
| <0.001 | dysgerminoma | NA | BeFree | Detail | |
| <0.001 | eclampsia | NA | BeFree | Detail | |
| 0.001 | Eczema | NA | BeFree | Detail | |
| 0.003 | Filarial Elephantiases | NA | LHGDN | Detail | |
| 0.081 | Experimental Autoimmune Encephalomyelitis | NA | BeFree,RGD | Detail | |
| 0.005 | Endometrial Neoplasms | NA | GAD,LHGDN | Detail | |
| 0.006 | endometriosis | NA | BeFree,LHGDN | Detail | |
| <0.001 | endophthalmitis | Surprisingly, B. cereus-infected TLR4(-/-) eyes also had significantly less intr... | BeFree | 26195555 | Detail |
| <0.001 | Eosinophilia | TLR4-deficient mice challenged with either OVA preparation showed eosinophilia b... | BeFree | 24968337 | Detail |
| 0.003 | epilepsy | NA | BeFree,GAD | Detail | |
| 0.003 | Escherichia coli Infections | NA | LHGDN | Detail | |
| <0.001 | peptic esophagitis | NA | BeFree | Detail | |
| 0.080 | Fungal eye infections | NA | RGD | Detail | |
| 0.002 | Fallopian Tube Diseases | NA | GAD | Detail | |
| <0.001 | Fatigue | NA | BeFree | Detail | |
| 0.121 | Fatty Liver | NA | BeFree,CTD_human | Detail | |
| 0.002 | Fetal Diseases | NA | GAD | Detail | |
| 0.005 | Fetal Membranes, Premature Rupture | NA | GAD | Detail | |
| <0.001 | Gangrene | NA | BeFree | Detail | |
| 0.003 | Gastritis, Atrophic | A decreased risk of GC was observed in H. pylori negative and TLR4-2081(AG+AA) g... | BeFree,GAD | 25084512 | Detail |
| 0.003 | Angiolymphoid hyperplasia | NA | LHGDN | Detail | |
| 0.001 | Gingival Diseases | NA | BeFree | Detail | |
| <0.001 | gingivitis | NA | BeFree | Detail | |
| 0.003 | glaucoma | NA | BeFree,LHGDN | Detail | |
| 0.002 | Glaucoma, Open-Angle | NA | GAD | Detail | |
| <0.001 | Glioma | NA | BeFree | Detail | |
| <0.001 | glomerulonephritis | NA | BeFree | Detail | |
| 0.121 | IgA glomerulonephritis | NA | BeFree,CTD_human | Detail | |
| <0.001 | gonorrhea | NA | BeFree | Detail | |
| 0.003 | Graft-vs-Host Disease | NA | BeFree,GAD | Detail | |
| <0.001 | Guillain-Barre syndrome | NA | BeFree | Detail | |
| 0.003 | Hay fever | NA | BeFree,GAD | Detail | |
| 0.002 | Head and Neck Neoplasms | NA | GAD | Detail | |
| <0.001 | congestive heart failure | NA | BeFree | Detail | |
| <0.001 | hemochromatosis | NA | BeFree | Detail | |
| <0.001 | hemolytic-uremic syndrome | NA | BeFree | Detail | |
| <0.001 | Severe Dengue | NA | BeFree | Detail | |
| <0.001 | hepatic encephalopathy | Patients with TLR4 polymorphisms had a higher incidence of previous hepatic ence... | BeFree | 25516666 | Detail |
| 0.005 | hepatitis B | Toll-like receptor 4 and hepatitis B infection: molecular mechanisms and pathoge... | BeFree,GAD | 25014492 | Detail |
| 0.003 | Hepatitis, Alcoholic | NA | BeFree,LHGDN | Detail | |
| 0.005 | hepatitis C | The association of toll-like receptor 4 polymorphism with hepatitis C virus infe... | BeFree,LHGDN | 25177689 | Detail |
| 0.080 | hepatorenal syndrome | NA | RGD | Detail | |
| 0.021 | HIV Infections | HIV Tat acts on endogenous retroviruses of the W family and this occurs via Toll... | BeFree,GAD | 25250834 | Detail |
| 0.021 | HIV Infections | Furthermore, neutrophils from HESN challenged with HIV-1 and stimulated with TLR... | BeFree,GAD | 25785697 | Detail |
| 0.002 | Hodgkin Disease | NA | GAD | Detail | |
| 0.080 | Hyperalgesia | NA | RGD | Detail | |
| 0.003 | Hypercholesterolemia | NA | BeFree,GAD | Detail | |
| <0.001 | Hypercholesterolemia, Familial | NA | BeFree | Detail | |
| <0.001 | hyperglycemia | Collectively, our novel data suggest that hyperglycemia induces TLR-2 and TLR-4 ... | BeFree | 25610879 | Detail |
| 0.015 | Hypersensitivity | NA | GAD,LHGDN | Detail | |
| 0.007 | Immediate hypersensitivity | NA | GAD | Detail | |
| 0.002 | Hypertensive disease | NA | GAD | Detail | |
| 0.001 | pulmonary hypertension | Animal study proved that HMGB1 contributed to the pathogenesis of experimental p... | BeFree | 25050807 | Detail |
| 0.001 | pulmonary hypertension | TLR4 D299 G showed an inverse association with pulmonary hypertension. | BeFree | 25182168 | Detail |
| 0.080 | ileitis | NA | RGD | Detail | |
| <0.001 | Immunologic Deficiency Syndromes | NA | BeFree | Detail | |
| 0.002 | Female infertility | NA | GAD | Detail | |
| 0.150 | Inflammation | NA | CTD_human,GAD,LHGDN | Detail | |
| 0.034 | Inflammatory Bowel Diseases | Polymorphisms in the inflammatory pathway genes TLR2, TLR4, TLR9, LY96, NFKBIA, ... | BeFree,GAD,LHGDN | 24971461 | Detail |
| 0.034 | Inflammatory Bowel Diseases | The meta-analysis provides evidence that TLR4 polymorphisms confer a significant... | BeFree,GAD,LHGDN | 25492126 | Detail |
| 0.002 | influenza | Pharmacological inhibitors of TLR4 (E5564) exerted similar effects like those de... | BeFree | 24968347 | Detail |
| 0.002 | Insulin resistance | NA | GAD | Detail | |
| <0.001 | Intestinal Diseases | NA | BeFree | Detail | |
| <0.001 | irritable bowel syndrome | NA | BeFree | Detail | |
| 0.003 | ischemia | NA | BeFree | Detail | |
| 0.003 | arthropathy | NA | BeFree,LHGDN | Detail | |
| <0.001 | keratitis | NA | BeFree | Detail | |
| <0.001 | Keratoconjunctivitis, Vernal | NA | BeFree | Detail | |
| 0.003 | Kidney Diseases | NA | BeFree,GAD | Detail | |
| <0.001 | Kidney Failure, Acute | Targeting the HMGB1-TLR4 pathway might enable development of a new therapeutic s... | BeFree | 24646859 | Detail |
| 0.005 | Kidney Failure, Chronic | NA | GAD,LHGDN | Detail | |
| 0.002 | Premature Obstetric Labor | NA | GAD | Detail | |
| <0.001 | Legg-Calve-Perthes disease | Association of gene variants in TLR4 and IL-6 genes with Perthes disease. | BeFree | 25233690 | Detail |
| 0.003 | Legionnaires' disease | NA | BeFree,GAD | Detail | |
| <0.001 | leishmaniasis | NA | BeFree | Detail | |
| <0.001 | Leishmaniasis, Cutaneous | NA | BeFree | Detail | |
| <0.001 | Leishmaniasis, Visceral | L. donovani increases the expression of TLR4 and TLR9 in patients with VL and TL... | BeFree | 25982946 | Detail |
| 0.003 | leprosy | NA | BeFree,GAD | Detail | |
| <0.001 | leukemia | NA | BeFree | Detail | |
| <0.001 | chronic lymphocytic leukemia | Toll-like receptor 4 and 9 expression in B-chronic lymphocytic leukemia: relatio... | BeFree | 24144314 | Detail |
| <0.001 | lymphoid leukemia | NA | BeFree | Detail | |
| <0.001 | Acute lymphocytic leukemia | NA | BeFree | Detail | |
| <0.001 | acute monocytic leukemia | NA | BeFree | Detail | |
| 0.001 | Leukemia, Myelocytic, Acute | Moreover, we observed that expression of TLR2 and TLR4 was significantly higher ... | BeFree | 25412934 | Detail |
| 0.001 | Leukemia, Myelocytic, Acute | Polymorphisms of Toll-like receptors (TLR2 and TLR4) are associated with the ris... | BeFree | 25427560 | Detail |
| <0.001 | Leukemia, T-Cell | NA | BeFree | Detail | |
| <0.001 | leukopenia | NA | BeFree | Detail | |
| 0.002 | lipodystrophy | NA | GAD | Detail | |
| 0.010 | liver cirrhosis | Therefore, the aim of this review is to present the recent data regarding the im... | BeFree,GAD | 25014492 | Detail |
| 0.010 | liver cirrhosis | Cytokine production in patients with cirrhosis and TLR4 polymorphisms. | BeFree,GAD | 25516666 | Detail |
| <0.001 | Liver Cirrhosis, Alcoholic | NA | BeFree | Detail | |
| 0.003 | Biliary cirrhosis | NA | LHGDN | Detail | |
| 0.080 | Liver Cirrhosis, Experimental | NA | RGD | Detail | |
| 0.004 | Liver diseases | NA | BeFree,GAD | Detail | |
| 0.003 | Alcoholic Liver Diseases | NA | BeFree,GAD | Detail | |
| 0.080 | Lung diseases | NA | BeFree,RGD | Detail | |
| 0.002 | Lung Diseases, Fungal | NA | GAD | Detail | |
| 0.009 | Chronic Obstructive Airway Disease | NA | BeFree,GAD,LHGDN | Detail | |
| 0.012 | Tuberculosis, Pulmonary | In the present study, we investigated whether variants in the TLR-1 1805T/G (Ile... | BeFree | 20797905 | Detail |
| 0.123 | Lung Neoplasms | NA | CTD_human,LHGDN | Detail | |
| <0.001 | Lupus Vulgaris | NA | BeFree | Detail | |
| <0.001 | Lupus Erythematosus, Discoid | NA | BeFree | Detail | |
| 0.003 | Lupus Erythematosus, Systemic | Association of TLR4 (D299G, T399I), TLR9 -1486T>C, TIRAP S180L and TNF-α promote... | BeFree | 25182168 | Detail |
| <0.001 | lupus nephritis | NA | BeFree | Detail | |
| 0.005 | lymphoma | NA | GAD | Detail | |
| 0.005 | Lymphoma, Non-Hodgkin | NA | BeFree,GAD | Detail | |
| 0.016 | malaria | NA | BeFree,GAD,LHGDN | Detail | |
| 0.002 | Malaria, Cerebral | NA | GAD | Detail | |
| 0.007 | Malaria, Falciparum | NA | GAD | Detail | |
| 0.080 | mastitis | NA | RGD | Detail | |
| <0.001 | measles | NA | BeFree | Detail | |
| 0.127 | melanoma | TLR4 signaling may contribute to melanoma progression, and caution should be exe... | BeFree,CTD_human,LHGDN | 25175033 | Detail |
| <0.001 | melioidosis | NA | BeFree | Detail | |
| <0.001 | meningioma | NA | BeFree | Detail | |
| <0.001 | meningitis | NA | BeFree | Detail | |
| <0.001 | meningococcal meningitis | NA | BeFree | Detail | |
| 0.008 | Meningococcal Infections | NA | BeFree,GAD | Detail | |
| <0.001 | Meningococcemia | NA | BeFree | Detail | |
| <0.001 | Metabolic Diseases | NA | BeFree | Detail | |
| 0.002 | Metaplasia | NA | GAD | Detail | |
| <0.001 | mitral valve stenosis | NA | BeFree | Detail | |
| 0.003 | Mouth Neoplasms | NA | LHGDN | Detail | |
| 0.003 | multiple myeloma | NA | BeFree,GAD | Detail | |
| 0.007 | Multiple Organ Failure | NA | GAD | Detail | |
| 0.012 | multiple sclerosis | NA | BeFree,GAD,LHGDN | Detail | |
| 0.002 | Musculoskeletal Diseases | NA | GAD | Detail | |
| 0.003 | myasthenia gravis | We observed that TLR4 stimulation led to a more pronounced Teff activatory statu... | BeFree,LHGDN | 24397961 | Detail |
| <0.001 | Mycobacterium Infections | NA | BeFree | Detail | |
| <0.001 | Mycoplasma Infections | NA | BeFree | Detail | |
| 0.005 | Mycoses | We speculated that cross-talk occurs between TREM-1 and Toll-like receptor-4 (TL... | BeFree,GAD | 25242387 | Detail |
| 0.005 | Mycoses | Moreover, we observed that expression of TLR2 and TLR4 was significantly higher ... | BeFree,GAD | 25412934 | Detail |
| 0.003 | mycosis fungoides | NA | BeFree,LHGDN | Detail | |
| 0.021 | myocardial infarction | NA | BeFree,GAD,LHGDN | Detail | |
| 0.080 | Myocardial Reperfusion Injury | NA | RGD | Detail | |
| <0.001 | myocarditis | NA | BeFree | Detail | |
| <0.001 | Nasal Polyps | NA | BeFree | Detail | |
| 0.120 | Neoplasm Invasiveness | NA | CTD_human | Detail | |
| 0.124 | Neoplasm Metastasis | These findings indicated that TLR4 may participate in the progression and metast... | BeFree,CTD_human | 25299052 | Detail |
| 0.124 | Neoplasm Metastasis | In our study, two HCC cell lines and a splenic vein metastasis of the nude mouse... | BeFree,CTD_human | 25511737 | Detail |
| 0.124 | Neoplasm Metastasis | This study shows that TLR4, IL17A/F and IL23R polymorphisms are involved in the ... | BeFree,CTD_human | 25911397 | Detail |
| 0.005 | Neoplasm Recurrence, Local | NA | GAD | Detail | |
| <0.001 | lipoid nephrosis | In order to investigate this, we studied TLR4 gene and protein expression and TL... | BeFree | 24786705 | Detail |
| 0.080 | Neuralgia | NA | BeFree,RGD | Detail | |
| 0.080 | Neuritis, Autoimmune, Experimental | NA | RGD | Detail | |
| <0.001 | neutropenia | NA | BeFree | Detail | |
| 0.003 | Niemann-Pick Diseases | NA | LHGDN | Detail | |
| <0.001 | Nodule | NA | BeFree | Detail | |
| 0.089 | obesity | Immune cell Toll-like receptor 4 mediates the development of obesity- and endoto... | BeFree,GAD,RGD | 24794440 | Detail |
| 0.089 | obesity | Thus, we evaluated the association of 17 single-nucleotide polymorphisms (SNPs) ... | BeFree,GAD,RGD | 25224558 | Detail |
| 0.089 | obesity | However, a high-fat diet activates TLR-2s, and obesity activates TLR-4s and indu... | BeFree,GAD,RGD | 25840582 | Detail |
| 0.089 | obesity | Interestingly, NF-κB activity assays showed obese donor hepatocytes were resista... | BeFree,GAD,RGD | 26113297 | Detail |
| <0.001 | Opportunistic Infections | NA | BeFree | Detail | |
| 0.002 | Degenerative polyarthritis | NA | BeFree | Detail | |
| <0.001 | osteomyelitis | NA | BeFree | Detail | |
| <0.001 | Ear Inflammation | NA | BeFree | Detail | |
| 0.006 | otitis media | NA | BeFree,GAD,LHGDN | Detail | |
| <0.001 | ovarian carcinoma | NA | BeFree | Detail | |
| 0.080 | Pain | NA | RGD | Detail | |
| 0.090 | pancreatitis | NA | GAD,LHGDN,RGD | Detail | |
| <0.001 | Paratuberculosis | NA | BeFree | Detail | |
| 0.003 | Parkinson disease | Here, we report increases in toll-like receptors 2 and 4 expression in circulati... | BeFree,GAD | 25522431 | Detail |
| <0.001 | Peptic Ulcer | NA | BeFree | Detail | |
| <0.001 | Chronic periaortitis | NA | BeFree | Detail | |
| <0.001 | periapical periodontitis | Polymorphism of the CD14 and TLR4 genes and post-treatment apical periodontitis. | BeFree | 24461398 | Detail |
| 0.003 | familial Mediterranean fever | TLR2 and TLR4 gene expression levels and associated factors during acute attack ... | BeFree,GAD | 25208763 | Detail |
| 0.006 | Periodontal Diseases | NA | BeFree,GAD | Detail | |
| 0.002 | Periodontal Pocket | NA | GAD | Detail | |
| 0.031 | periodontitis | TLR4 immunoreactivity was found in healthy gingival epithelium and periodontitis... | BeFree,GAD,LHGDN | 24620831 | Detail |
| 0.009 | Periodontitis, Juvenile | NA | BeFree,GAD | Detail | |
| 0.120 | Peripheral neuropathy | NA | CTD_human | Detail | |
| <0.001 | peritonitis | NA | BeFree | Detail | |
| <0.001 | pituitary adenoma | NA | BeFree | Detail | |
| <0.001 | Pituitary Diseases | NA | BeFree | Detail | |
| 0.003 | Pituitary Neoplasms | NA | BeFree,LHGDN | Detail | |
| 0.007 | Pneumococcal Infections | NA | BeFree,GAD | Detail | |
| <0.001 | polymyalgia rheumatica | NA | BeFree | Detail | |
| 0.015 | pre-eclampsia | NA | GAD,LHGDN | Detail | |
| 0.002 | Precancerous Conditions | NA | GAD | Detail | |
| 0.002 | Pregnancy Complications, Hematologic | NA | GAD | Detail | |
| 0.005 | Pregnancy Complications, Infectious | NA | GAD | Detail | |
| 0.128 | Prostatic Neoplasms | NA | CTD_human,GAD,LHGDN | Detail | |
| <0.001 | psoriasis | NA | BeFree | Detail | |
| 0.002 | Puerperal Disorders | NA | GAD | Detail | |
| <0.001 | pulmonary emphysema | NA | BeFree | Detail | |
| 0.080 | pulpitis | NA | RGD | Detail | |
| 0.003 | pyelonephritis | NA | BeFree,GAD | Detail | |
| 0.002 | Rectal Fistula | NA | GAD | Detail | |
| <0.001 | kidney failure | NA | BeFree | Detail | |
| 0.202 | Reperfusion Injury | NA | CTD_human,GAD,RGD | Detail | |
| <0.001 | Respiratory Distress Syndrome, Adult | NA | BeFree | Detail | |
| 0.120 | Respiratory Hypersensitivity | NA | CTD_human | Detail | |
| 0.009 | Respiratory Syncytial Virus Infections | Two independent populations of infants with RSV bronchiolitis revealed that the ... | BeFree,GAD | 25555213 | Detail |
| 0.009 | Respiratory Syncytial Virus Infections | Genetic Polymorphisms of Toll-like Receptor 4 are Associated with Respiratory Sy... | BeFree,GAD | 26642699 | Detail |
| <0.001 | Respiratory Tract Infections | NA | BeFree | Detail | |
| <0.001 | Rickettsia Infections | NA | BeFree | Detail | |
| <0.001 | Rotavirus Infections | NA | BeFree | Detail | |
| 0.003 | Salmonella infections | NA | BeFree,GAD | Detail | |
| 0.011 | sarcoidosis | NA | BeFree,GAD,LHGDN | Detail | |
| <0.001 | Kaposi sarcoma | NA | BeFree | Detail | |
| 0.004 | systemic scleroderma | NA | BeFree,LHGDN | Detail | |
| <0.001 | scrub typhus | NA | BeFree | Detail | |
| 0.001 | Seizures | TLR 4 T399I and TLR9 -1486 T>C showed a positive association with seizures and p... | BeFree | 25182168 | Detail |
| 0.002 | Septicaemia due to gram-negative organism, unspecified | NA | BeFree | Detail | |
| 0.005 | Shock | NA | GAD,LHGDN | Detail | |
| 0.007 | Septic Shock | NA | GAD,LHGDN | Detail | |
| <0.001 | Shy-Drager Syndrome | NA | BeFree | Detail | |
| <0.001 | Signs and Symptoms, Respiratory | NA | BeFree | Detail | |
| 0.002 | Dermatologic disorders | NA | GAD | Detail | |
| 0.010 | ankylosing spondylitis | Whole body hyperthermia treatment increases interleukin 10 and toll-like recepto... | BeFree,GAD,LHGDN | 25256892 | Detail |
| <0.001 | status epilepticus | NA | BeFree | Detail | |
| 0.003 | Stomach Diseases | Associations of a TLR4 single-nucleotide polymorphism with H. pylori associated ... | BeFree,GAD | 24508388 | Detail |
| 0.021 | Stomach Neoplasms | NA | GAD | Detail | |
| 0.002 | Streptococcal Infections | NA | GAD | Detail | |
| 0.080 | Subarachnoid Hemorrhage | NA | RGD | Detail | |
| 0.009 | Giant Cell Arteritis | NA | BeFree,GAD | Detail | |
| 0.002 | toxoplasmosis | NA | GAD | Detail | |
| <0.001 | Trematode Infections | In particular, decreased expression of let-7i, a tumor suppressor miRNA, was fou... | BeFree | 25217977 | Detail |
| <0.001 | Trichomonas Infections | NA | BeFree | Detail | |
| <0.001 | Chagas disease | NA | BeFree | Detail | |
| 0.017 | tuberculosis | NA | BeFree,GAD,LHGDN | Detail | |
| 0.003 | typhoid fever | NA | BeFree,GAD | Detail | |
| <0.001 | ureteral obstruction | NA | BeFree | Detail | |
| 0.011 | urinary tract infection | NA | BeFree,GAD,LHGDN | Detail | |
| 0.003 | Uterine Diseases | NA | LHGDN | Detail | |
| 0.081 | uveitis | Surprisingly, B. cereus-infected TLR4(-/-) eyes also had significantly less intr... | BeFree,RGD | 26195555 | Detail |
| 0.003 | anterior uveitis | NA | LHGDN | Detail | |
| <0.001 | Vascular Diseases | NA | BeFree | Detail | |
| 0.003 | vasculitis | NA | LHGDN | Detail | |
| 0.006 | Virus Diseases | The association of toll-like receptor 4 polymorphism with hepatitis C virus infe... | BeFree,GAD | 25177689 | Detail |
| 0.002 | Low Vision | NA | GAD | Detail | |
| <0.001 | vitiligo | NA | BeFree | Detail | |
| <0.001 | von Willebrand Disease | NA | BeFree | Detail | |
| <0.001 | Wheezing | NA | BeFree | Detail | |
| 0.019 | Helicobacter Infections | NA | GAD | Detail | |
| 0.003 | B-Cell Lymphomas | NA | BeFree,LHGDN | Detail | |
| 0.003 | diffuse large B-cell lymphoma | NA | BeFree,GAD | Detail | |
| <0.001 | Lymphoma, Large-Cell, Follicular | NA | BeFree | Detail | |
| <0.001 | Peripheral Vascular Diseases | NA | BeFree | Detail | |
| <0.001 | severe combined immunodeficiency | NA | BeFree | Detail | |
| 0.003 | Bronchial Hyperreactivity | NA | BeFree,GAD | Detail | |
| 0.006 | bacterial vaginosis | NA | BeFree,GAD | Detail | |
| 0.002 | Neoplasms, Second Primary | NA | GAD | Detail | |
| 0.001 | antiphospholipid syndrome | NA | BeFree | Detail | |
| 0.002 | Polyendocrinopathies, Autoimmune | The ability of PGA to induce TNF-α and IL-6 was retained in TLR4(-/-) but not TL... | BeFree | 26195551 | Detail |
| 0.004 | Gram-Negative Bacterial Infections | Toll-like receptor 4 polymorphisms in gram-negative bacterial infections of Han ... | BeFree,GAD | 25217737 | Detail |
| 0.006 | Arthritis, Reactive | NA | BeFree,GAD | Detail | |
| <0.001 | Meningitis, Bacterial | NA | BeFree | Detail | |
| <0.001 | polymyositis | Co-localization between autophagic marker, LC3, and TLR4 and TLR3 was observed n... | BeFree | 25365350 | Detail |
| <0.001 | acute leukemia | We especially observed that mRNA expression of TLR2 and TLR4 was significantly h... | BeFree | 25624047 | Detail |
| <0.001 | hemorrhagic cystitis | NA | BeFree | Detail | |
| <0.001 | Chronic sinusitis | NA | BeFree | Detail | |
| <0.001 | acute cystitis | NA | BeFree | Detail | |
| 0.002 | Left Ventricular Hypertrophy | NA | GAD | Detail | |
| 0.080 | sciatic neuropathy | NA | RGD | Detail | |
| <0.001 | Active tuberculosis | NA | BeFree | Detail | |
| 0.017 | Premature Birth | NA | GAD,LHGDN | Detail | |
| <0.001 | renal fibrosis | NA | BeFree | Detail | |
| 0.001 | Myocardial Ischemia | Activation of liver X receptor improves viability of adipose-derived mesenchymal... | BeFree | 24915051 | Detail |
| <0.001 | Adenocarcinoma of lung (disorder) | NA | BeFree | Detail | |
| 0.001 | low tension glaucoma | NA | BeFree | Detail | |
| <0.001 | Malignant neoplasm of mouth | Association of TLR2, TLR3, TLR4 and CD14 genes polymorphisms with oral cancer ri... | BeFree | 23796347 | Detail |
| <0.001 | Malignant neoplasm of gallbladder | NA | BeFree | Detail | |
| <0.001 | Secondary malignant neoplasm of lung | NA | BeFree | Detail | |
| <0.001 | Hearing Loss, Mixed Conductive-Sensorineural | NA | BeFree | Detail | |
| 0.002 | acute myocardial infarction | NA | BeFree | Detail | |
| <0.001 | Old myocardial infarction | NA | BeFree | Detail | |
| <0.001 | Atherosclerosis of aorta | NA | BeFree | Detail | |
| <0.001 | allergic asthma | NA | BeFree | Detail | |
| <0.001 | adrenoleukodystrophy | NA | BeFree | Detail | |
| 0.002 | AIDS-Related Opportunistic Infections | NA | GAD | Detail | |
| 0.080 | Liver Failure, Acute | NA | RGD | Detail | |
| 0.006 | HELLP syndrome | NA | BeFree,GAD,LHGDN | Detail | |
| <0.001 | Right Ventricular Hypertrophy | NA | BeFree | Detail | |
| <0.001 | hidradenitis suppurativa | NA | BeFree | Detail | |
| <0.001 | Aortic Aneurysm, Thoracic | Thus, TLR4 pathway should seem to have a key role in sporadic TAA. | BeFree | 25120286 | Detail |
| <0.001 | Agenesis of corpus callosum | NA | BeFree | Detail | |
| 0.002 | Tumor Progression | Paclitaxel, a known TLR4 ligand, leads to activation of TLR4/MyD88-dependent pat... | BeFree | 24452475 | Detail |
| 0.002 | Tumor Progression | Our findings demonstrate that bladder cancer cell lines express functional TLR4 ... | BeFree | 25499923 | Detail |
| 0.002 | Tumor Progression | Toll like receptor 4 (TLR4), acting as a receptor for lipopolysaccharide (LPS), ... | BeFree | 25511737 | Detail |
| 0.002 | Periodontal Attachment Loss | NA | GAD | Detail | |
| 0.001 | Lichen Planus, Oral | NA | BeFree | Detail | |
| <0.001 | exfoliation syndrome | NA | BeFree | Detail | |
| <0.001 | hepatoblastoma | Toll-like receptor-4 is a target for suppression of proliferation and chemoresis... | BeFree | 26276725 | Detail |
| <0.001 | embryonal carcinoma | NA | BeFree | Detail | |
| <0.001 | Cervical Intraepithelial Neoplasia | NA | BeFree | Detail | |
| <0.001 | pediatric acute myeloblastic leukemia | NA | BeFree | Detail | |
| <0.001 | Lip and oral cavity carcinoma | Association of TLR2, TLR3, TLR4 and CD14 genes polymorphisms with oral cancer ri... | BeFree | 23796347 | Detail |
| <0.001 | X-linked agammaglobulinemia | NA | BeFree | Detail | |
| <0.001 | Adult type dermatomyositis | TLR4 and TLR3, two potent inducers of autophagy, were highly increased in IIM, w... | BeFree | 25365350 | Detail |
| <0.001 | Inflammatory pain | NA | BeFree | Detail | |
| <0.001 | gallbladder carcinoma | NA | BeFree | Detail | |
| <0.001 | Neonatal encephalopathy | LPS-induced monocyte TLR-4 was increased significantly in infants with NE on day... | BeFree | 25204207 | Detail |
| 0.001 | pancreatic carcinoma | NA | BeFree | Detail | |
| 0.001 | invasive aspergillosis | NA | BeFree | Detail | |
| 0.002 | Cancer of Nasopharynx | NA | GAD | Detail | |
| <0.001 | Papillary thyroid carcinoma | NA | BeFree | Detail | |
| 0.003 | Fibrosis, Liver | ACAT1-deficient and wild-type mice, or Toll-like receptor 4 (TLR4)(-/-)ACAT1(+/+... | BeFree | 24657401 | Detail |
| 0.003 | Fibrosis, Liver | A recent study reported that TLR4 gene polymorphisms are good prognostic predict... | BeFree | 25177689 | Detail |
| <0.001 | Prostate infection | NA | BeFree | Detail | |
| <0.001 | pelvic inflammatory disease | NA | BeFree | Detail | |
| 0.004 | coronary stenosis | The expression of TLR4 and TLR3 closely correlated with the severity of coronary... | BeFree,LHGDN | 24146036 | Detail |
| <0.001 | Dyslipidemias | NA | BeFree | Detail | |
| 0.001 | Malignant neoplasm of lung | Furthermore, using data generated by The Cancer Genome Atlas consortium, we demo... | BeFree | 26063617 | Detail |
| 0.136 | age related macular degeneration | NA | BeFree,CTD_human,GAD,LHGDN | Detail | |
| 0.080 | Acute Lung Injury | NA | RGD | Detail | |
| 0.006 | Mucosa-Associated Lymphoid Tissue Lymphoma | NA | BeFree,GAD,LHGDN | Detail | |
| 0.002 | Parasitemia | NA | GAD | Detail | |
| 0.006 | Systemic Inflammatory Response Syndrome | NA | BeFree,GAD,LHGDN | Detail | |
| <0.001 | Carcinoma, Lewis Lung | NA | BeFree | Detail | |
| 0.001 | Asymptomatic bacteriuria | NA | BeFree | Detail | |
| <0.001 | Chronic urinary tract infection | NA | BeFree | Detail | |
| <0.001 | Recurrent urinary tract infection | NA | BeFree | Detail | |
| <0.001 | Acne Conglobata | NA | BeFree | Detail | |
| <0.001 | Dermatomyositis, Childhood Type | Co-localization between autophagic marker, LC3, and TLR4 and TLR3 was observed n... | BeFree | 25365350 | Detail |
| <0.001 | Chronic arthritis | NA | BeFree | Detail | |
| <0.001 | Childhood asthma | NA | BeFree | Detail | |
| 0.010 | Chronic Periodontitis | NA | BeFree,GAD | Detail | |
| 0.080 | Pancreatitis, Acute Necrotizing | NA | RGD | Detail | |
| <0.001 | Necrosis of pancreas | NA | BeFree | Detail | |
| 0.120 | Lung Injury | NA | CTD_human | Detail | |
| <0.001 | Clinical infection | NA | BeFree | Detail | |
| <0.001 | Asymptomatic Infections | NA | BeFree | Detail | |
| <0.001 | Coinfection | NA | BeFree | Detail | |
| 0.080 | Herpes encephalitis | NA | RGD | Detail | |
| <0.001 | Respiratory syncytial virus bronchiolitis | The role of TLR4 and CD14 polymorphisms in the pathogenesis of respiratory syncy... | BeFree | 25572736 | Detail |
| <0.001 | Chronic viral hepatitis | NA | BeFree | Detail | |
| 0.002 | Infection by Candida albicans | NA | GAD | Detail | |
| <0.001 | Carcinoma breast stage IV | NA | BeFree | Detail | |
| <0.001 | Cancer of Head and Neck | NA | BeFree | Detail | |
| <0.001 | Liver and Intrahepatic Biliary Tract Carcinoma | NA | BeFree | Detail | |
| 0.120 | Adenocarcinoma Of Esophagus | NA | BeFree,CTD_human | Detail | |
| <0.001 | Sexual abuse | TLR2 and TLR4 risk genotype carrier state and history of childhood emotional, ph... | BeFree | 25790282 | Detail |
| <0.001 | Very Low Birth Weight | NA | BeFree | Detail | |
| <0.001 | Hemorrhagic Fever, Ebola | NA | BeFree | Detail | |
| 0.004 | cervix carcinoma | Cancer-derived immunoglobulin G promotes LPS-induced proinflammatory cytokine pr... | BeFree,GAD | 25179302 | Detail |
| 0.004 | cervix carcinoma | However, the C/C genotype for the TLR3 (c.1377 C>T) polymorphism and the Asp/Asp... | BeFree,GAD | 25373689 | Detail |
| <0.001 | Uremia syndrome | NA | BeFree | Detail | |
| <0.001 | Anastomosis | NA | BeFree | Detail | |
| <0.001 | Restenosis | NA | BeFree | Detail | |
| <0.001 | Senile Plaques | NA | BeFree | Detail | |
| 0.005 | Atrophic | NA | GAD,LHGDN | Detail | |
| <0.001 | Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse | NA | BeFree | Detail | |
| 0.003 | Neurocysticercosis | NA | BeFree,GAD | Detail | |
| 0.003 | Thyroid associated opthalmopathies | NA | BeFree,GAD | Detail | |
| <0.001 | Glaucoma, Primary Open Angle | NA | BeFree | Detail | |
| 0.121 | Stable angina | NA | BeFree,CTD_human | Detail | |
| <0.001 | Anterior myocardial infarction | NA | BeFree | Detail | |
| <0.001 | Chronic liver disease | NA | BeFree | Detail | |
| <0.001 | Malonic aciduria | Both in microalbuminuria and in overt DN, TLR4 mRNA and protein were overexpress... | BeFree | 24786705 | Detail |
| <0.001 | Malignant neoplasm of liver | NA | BeFree | Detail | |
| 0.001 | Malignant neoplasm of pancreas | NA | BeFree | Detail | |
| <0.001 | Depressive episode, unspecified | TLR2 and TLR4 risk genotype carrier state and history of childhood emotional, ph... | BeFree | 25790282 | Detail |
| <0.001 | gastric lymphoma | NA | BeFree | Detail | |
| 0.002 | Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site | NA | BeFree | Detail | |
| 0.024 | Malignant neoplasm of prostate | The role of TLR4 in the pathophysiology of several age-related diseases is also ... | BeFree,GAD | 25360682 | Detail |
| 0.024 | Malignant neoplasm of prostate | TLR4 activation by lipopolysaccharide confers survival advantage to growth facto... | BeFree,GAD | 25833062 | Detail |
| 0.082 | Endotoxemia | NA | GAD,RGD | Detail | |
| <0.001 | Pouchitis | NA | BeFree | Detail | |
| 0.003 | Hereditary hemochromatosis | NA | BeFree,GAD | Detail | |
| 0.002 | Postoperative infection | NA | GAD | Detail | |
| 0.002 | Atopy | NA | GAD | Detail | |
| <0.001 | multiple system atrophy | NA | BeFree | Detail | |
| <0.001 | Recurrent acute otitis media | NA | BeFree | Detail | |
| 0.002 | Immune thrombocytopenic purpura | NA | GAD | Detail | |
| <0.001 | Primary immune deficiency disorder | NA | BeFree | Detail | |
| <0.001 | Supragingival dental plaque | NA | BeFree | Detail | |
| 0.081 | Non-alcoholic Fatty Liver Disease | NA | BeFree,RGD | Detail | |
| 0.003 | Chronic Kidney Insufficiency | NA | BeFree,LHGDN | Detail | |
| <0.001 | lupus erythematosus | NA | BeFree | Detail | |
| <0.001 | Ichthyosis bullosa of Siemens | NA | BeFree | Detail | |
| <0.001 | neuropathy | NA | BeFree | Detail | |
| 0.002 | dementia | NA | GAD | Detail | |
| <0.001 | Overweight | NA | BeFree | Detail | |
| <0.001 | Chlamydia trachomatis infection | NA | BeFree | Detail | |
| 0.209 | Necrotizing Enterocolitis | Toll-like receptor-4 in human and mouse colonic epithelium is developmentally re... | BeFree,CTD_human,LHGDN,RGD | 25521917 | Detail |
| <0.001 | acute pyelonephritis | NA | BeFree | Detail | |
| <0.001 | Sleep Apnea, Obstructive | NA | BeFree | Detail | |
| 0.003 | Metabolic syndrome X | NA | BeFree,GAD | Detail | |
| 0.006 | Hepatitis B, Chronic | NA | BeFree,LHGDN | Detail | |
| 0.010 | Hepatitis C, Chronic | NA | BeFree,GAD | Detail | |
| 0.016 | malaria | The tlr-4 (D299G and T399I), tlr-9 (T-1486C and T-1237C) and tirap (S180L) genes... | BeFree | 21457584 | Detail |
| <0.001 | primary sclerosing cholangitis | NA | BeFree | Detail | |
| 0.002 | Carotid Atherosclerosis | NA | BeFree | Detail | |
| <0.001 | Chronic idiopathic urticaria | NA | BeFree | Detail | |
| <0.001 | Recurrent cystitis | NA | BeFree | Detail | |
| 0.006 | Carcinogenesis | The TLR4-2081G/A polymorphism seems to affect the risk of gastric carcinogenesis... | BeFree | 25084512 | Detail |
| 0.006 | Carcinogenesis | Stimulation of TLR4 with LPS promoted tumorigenesis and formed metastatic lesion... | BeFree | 25299052 | Detail |
| 0.006 | Carcinogenesis | AP reduced AOM/DSS-associated toxicities, prevented carcinogenesis, and decrease... | BeFree | 25412264 | Detail |
| 0.006 | Carcinogenesis | Toll like receptor 4 (TLR4), acting as a receptor for lipopolysaccharide (LPS), ... | BeFree | 25511737 | Detail |
| 0.005 | prostate carcinoma | The role of TLR4 in the pathophysiology of several age-related diseases is also ... | BeFree | 25360682 | Detail |
| 0.005 | prostate carcinoma | TLR4 activation by lipopolysaccharide confers survival advantage to growth facto... | BeFree | 25833062 | Detail |
| <0.001 | Gastro-esophageal reflux disease with esophagitis | NA | BeFree | Detail | |
| <0.001 | Epithelial ovarian cancer | Therefore, AO-I could significantly sensitize the response of MyD88(+) EOC cells... | BeFree | 24452475 | Detail |
| <0.001 | Epithelial ovarian cancer | Our data thus suggest that NF-κB signaling is important for maintenance of cispl... | BeFree | 25681684 | Detail |
| 0.001 | Carcinoma of lung | Furthermore, using data generated by The Cancer Genome Atlas consortium, we demo... | BeFree | 26063617 | Detail |
| 0.002 | Secondary malignant neoplasm of lymph node | Toll-like receptor 4 prompts human breast cancer cells invasiveness via lipopoly... | BeFree | 25299052 | Detail |
| <0.001 | Community acquired pneumonia | In addition, TLR4 A299G polymorphism was also associated with community-acquired... | BeFree | 25720378 | Detail |
| <0.001 | Infection of ear | NA | BeFree | Detail | |
| 0.002 | colon carcinoma | Expression of TLR2 and TLR4 receptor proteins on colon cancer cells were confirm... | BeFree | 24390484 | Detail |
| 0.002 | colon carcinoma | A novel inflammatory regulator TIPE2 inhibits TLR4-mediated development of colon... | BeFree | 24934366 | Detail |
| 0.002 | Carcinoma of bladder | Toll-like receptor 4 gene polymorphism downregulates gene expression and involve... | BeFree | 25472584 | Detail |
| 0.002 | Carcinoma of bladder | Our findings demonstrate that bladder cancer cell lines express functional TLR4 ... | BeFree | 25499923 | Detail |
| <0.001 | airway disease | NA | BeFree | Detail | |
| <0.001 | Acute anterior uveitis | NA | BeFree | Detail | |
| <0.001 | acne | NA | BeFree | Detail | |
| <0.001 | Microalbuminuria | Enhanced glomerular Toll-like receptor 4 expression and signaling in patients wi... | BeFree | 24786705 | Detail |
| <0.001 | Middle Cerebral Artery Occlusion | Using a middle cerebral artery occlusion (MCAO) model, triphenyltetrazolium chlo... | BeFree | 25738964 | Detail |
| <0.001 | cardiac event | NA | BeFree | Detail | |
| <0.001 | acute chest syndrome | NA | BeFree | Detail | |
| <0.001 | Gram-negative bacteremia | NA | BeFree | Detail | |
| <0.001 | End Stage Liver Disease | We retrospectively assessed incidence of SBIs in 336 adult ESLD patients enliste... | BeFree | 24361409 | Detail |
| <0.001 | Adrenal Cancer | NA | BeFree | Detail | |
| <0.001 | Carotid Artery Plaque | The results of our in silico analysis in vitro provide potential evidence that S... | BeFree | 25196434 | Detail |
| <0.001 | Inclusion Body Myopathy, Sporadic | Co-localization between autophagic marker, LC3, and TLR4 and TLR3 was observed n... | BeFree | 25365350 | Detail |
| 0.002 | brain infarction | NA | GAD | Detail | |
| <0.001 | Acute Cerebrovascular Accidents | NA | BeFree | Detail | |
| <0.001 | Cystitis and urethritis | NA | BeFree | Detail | |
| <0.001 | Post MI | NA | BeFree | Detail | |
| 0.002 | High altitude illness | NA | GAD | Detail | |
| <0.001 | Acute GVH disease | NA | BeFree | Detail | |
| <0.001 | Pancolitis | NA | BeFree | Detail | |
| <0.001 | Infectious disease of lung | High mobility group box 1 (HMGB1), a recently discovered potent pro-inflammatory... | BeFree | 24099632 | Detail |
| <0.001 | Intraepithelial Neoplasia | NA | BeFree | Detail | |
| 0.001 | Cerebral Ischemia | Emerging studies have focused on the effect of isoflurane (ISO) pretreatment on ... | BeFree | 25738964 | Detail |
| <0.001 | Arteriovenous Malformations, Cerebral | NA | BeFree | Detail | |
| <0.001 | Cerebral Aneurysm | NA | BeFree | Detail | |
| 0.120 | ovarian neoplasm | NA | CTD_human | Detail | |
| <0.001 | Renal ischaemia | Thus, an enhanced HMGB1-TLR4 pathway contributes to lung injury induced by bilat... | BeFree | 24646859 | Detail |
| <0.001 | Renal ischaemia | The protective effect on renal ischemia reperfusion injury Is mediated by IgM AL... | BeFree | 24711004 | Detail |
| 0.001 | precancerous lesions | NA | BeFree | Detail | |
| <0.001 | cholecystolithiasis | NA | BeFree | Detail | |
| 0.001 | Vascular inflammations | NA | BeFree | Detail | |
| 0.004 | Ischemic stroke | NA | BeFree,GAD | Detail | |
| 0.129 | Acute coronary syndrome | NA | BeFree,CTD_human,GAD,LHGDN | Detail | |
| <0.001 | Pancreas infection | NA | BeFree | Detail | |
| <0.001 | Primary infection NOS | NA | BeFree | Detail | |
| <0.001 | Free plasma hemoglobin (disorder) | Studies suggest that in addition to effects of cell free plasma hemoglobin on sc... | BeFree | 25398989 | Detail |
| <0.001 | Spondylarthropathies | NA | BeFree | Detail | |
| <0.001 | Arthritis, Collagen-Induced | NA | BeFree | Detail | |
| <0.001 | Malignant neoplasm of ovary | NA | BeFree | Detail | |
| <0.001 | Graft ischaemia | NA | BeFree | Detail | |
| <0.001 | Squamous cell carcinoma of the head and neck | NA | BeFree | Detail | |
| 0.003 | Stenosis | NA | LHGDN | Detail | |
| <0.001 | Fungal keratitis | NA | BeFree | Detail | |
| 0.002 | Blood pressure finding | NA | GAD | Detail | |
| 0.002 | Systemic arterial pressure | NA | GAD | Detail | |
| <0.001 | Inflammatory disorder | TLR3 and TLR4 are known to act as anti-inflammatory and pro-inflammatory factors... | BeFree | 24845156 | Detail |
| <0.001 | Chronic inflammatory disorder | NA | BeFree | Detail | |
| <0.001 | Precursor B-cell lymphoblastic leukemia | NA | BeFree | Detail | |
| <0.001 | Eosinophilic disorder | TLR4-deficient mice challenged with either OVA preparation showed eosinophilia b... | BeFree | 24968337 | Detail |
| <0.001 | gastric cardia carcinoma | NA | BeFree | Detail | |
| <0.001 | Gastric Mucosa-Associated Lymphoid Tissue Lymphoma | NA | BeFree | Detail | |
| <0.001 | Epithelioma | NA | BeFree | Detail | |
| 0.120 | hearing impairment | NA | CTD_human | Detail | |
| <0.001 | Primary Lesion | TLR4 ligands have received attention as immunotherapies; therefore, we assessed ... | BeFree | 25175033 | Detail |
| <0.001 | Avascular necrosis of the capital femoral epiphysis | Association of gene variants in TLR4 and IL-6 genes with Perthes disease. | BeFree | 25233690 | Detail |
| <0.001 | Neurological ventriculitis | NA | BeFree | Detail | |
| <0.001 | Bacteroides fragilis infection in conditions classified elsewhere and of unspecified site | NA | BeFree | Detail | |
| <0.001 | Mammary Neoplasms | This study identifies a novel dichotomous role for TLR4 as a growth regulator an... | BeFree | 26063617 | Detail |
| <0.001 | Cerebral abscess | NA | BeFree | Detail | |
| <0.001 | Hepatocarcinogenesis | NA | BeFree | Detail | |
| <0.001 | Tumor Angiogenesis | NA | BeFree | Detail | |
| 0.008 | colorectal cancer | Association between Toll-like receptor 4 and interleukin 17 gene polymorphisms a... | BeFree,GAD | 25216863 | Detail |
| 0.008 | colorectal cancer | Polymorphisms in NFKB1 and TLR4 and interaction with dietary and life style fact... | BeFree,GAD | 25705893 | Detail |
| <0.001 | brain edema | Using a middle cerebral artery occlusion (MCAO) model, triphenyltetrazolium chlo... | BeFree | 25738964 | Detail |
| <0.001 | fertility disorders | NA | BeFree | Detail | |
| 0.080 | Renal Insufficiency | NA | RGD | Detail | |
| <0.001 | Warm Ischemia | NA | BeFree | Detail | |
| <0.001 | Nephrogenic Fibrosing Dermopathy | NA | BeFree | Detail | |
| 0.002 | Cirrhosis | Therefore, the aim of this review is to present the recent data regarding the im... | BeFree | 25014492 | Detail |
| 0.002 | Cirrhosis | Cytokine production in patients with cirrhosis and TLR4 polymorphisms. | BeFree | 25516666 | Detail |
| <0.001 | Macular dystrophy, corneal type 1 | Both in microalbuminuria and in overt DN, TLR4 mRNA and protein were overexpress... | BeFree | 24786705 | Detail |
| <0.001 | Disorder characterized by eosinophilia | TLR4-deficient mice challenged with either OVA preparation showed eosinophilia b... | BeFree | 24968337 | Detail |
| 0.002 | Pneumonia, Ventilator-Associated | NA | GAD | Detail | |
| <0.001 | Glomerulonephritis, Minimal Change | In order to investigate this, we studied TLR4 gene and protein expression and TL... | BeFree | 24786705 | Detail |
| <0.001 | Peripheral Arterial Diseases | Our aim is to study a transcriptional activation pathway of the innate immune sy... | BeFree | 24472415 | Detail |
| <0.001 | Intraocular Infection | Unexpected Roles for Toll-Like Receptor 4 and TRIF in Intraocular Infection with... | BeFree | 26195555 | Detail |
| <0.001 | Generalized chronic periodontitis | NA | BeFree | Detail | |
| 0.001 | Severe Sepsis | NA | BeFree | Detail | |
| <0.001 | Meningioma, benign, no ICD-O subtype | NA | BeFree | Detail | |
| <0.001 | IRAK4 Deficiency | NA | BeFree | Detail | |
| <0.001 | Recurrent infections (sinusitis and bacterial pneumonia and meningitis) | NA | BeFree | Detail | |
| <0.001 | autoimmune lymphoproliferative syndrome type 2B | NA | BeFree | Detail | |
| <0.001 | VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding) | NA | BeFree | Detail | |
| 0.080 | Emphysema, Hereditary Pulmonary | NA | MGD | Detail | |
| <0.001 | Hypotrichosis simplex | NA | BeFree | Detail | |
| <0.001 | PHOTOPAROXYSMAL RESPONSE 1 | TLR 4 T399I and TLR9 -1486 T>C showed a positive association with seizures and p... | BeFree | 25182168 | Detail |
| 0.134 | coronary artery disease | TLR3 and TLR4 as potential clinically biomarkers of cardiovascular risk in coron... | BeFree,CTD_human,GAD,LHGDN | 24146036 | Detail |
| 0.134 | coronary artery disease | Circulating Toll-like receptor 4-responsive microRNA panel in patients with coro... | BeFree,CTD_human,GAD,LHGDN | 25385173 | Detail |
| 0.134 | coronary artery disease | The effect of genetic polymorphisms of TLR2 and TLR4 in Turkish patients with co... | BeFree,CTD_human,GAD,LHGDN | 25542811 | Detail |
| 0.002 | temporal arteritis | NA | GAD | Detail | |
| <0.001 | Precursor Cell Lymphoblastic Leukemia Lymphoma | NA | BeFree | Detail | |
| 0.120 | Macular Degeneration, Age-Related, 10 | NA | CTD_human | Detail | |
| 0.003 | liver carcinoma | Therefore, the aim of this review is to present the recent data regarding the im... | BeFree | 25014492 | Detail |
| 0.003 | liver carcinoma | A functional variant at miR-34a binding site in toll-like receptor 4 gene alters... | BeFree | 25179842 | Detail |
| 0.003 | liver carcinoma | Toll like receptor 4 facilitates invasion and migration as a cancer stem cell ma... | BeFree | 25511737 | Detail |
| 0.003 | Pulmonary Aspergillosis | NA | BeFree,LHGDN | Detail | |
| <0.001 | Bronchopulmonary Aspergillosis | NA | BeFree | Detail | |
| 0.006 | Allergic rhinitis (disorder) | NA | BeFree,GAD | Detail | |
| 0.080 | Acute kidney injury | NA | RGD | Detail | |
| <0.001 | Steatohepatitis | NA | BeFree | Detail | |
| <0.001 | Infectious Otitis Media | NA | BeFree | Detail | |
| 0.002 | Infection of amniotic sac and membranes, unspecified, unspecified trimester, not applicable or unspecified | NA | GAD | Detail | |
| <0.001 | Macroalbuminuric diabetic nephropathy | Toll-like receptor 4 (TLR4), a component of the innate immune system, is recogni... | BeFree | 24786705 | Detail |
| 0.002 | Chronic ulcerative colitis | NA | GAD | Detail | |
| <0.001 | Juvenile dermatomyositis | Co-localization between autophagic marker, LC3, and TLR4 and TLR3 was observed n... | BeFree | 25365350 | Detail |
| <0.001 | Nasopharyngeal carcinoma | NA | BeFree | Detail | |
| <0.001 | Plaque, Amyloid | NA | BeFree | Detail | |
| <0.001 | limb ischemia | NA | BeFree | Detail | |
| <0.001 | GASTRIC CANCER, INTESTINAL | NA | BeFree | Detail | |
| 0.002 | Pulmonary function (finding) | NA | GAD | Detail | |
| <0.001 | Nonalcoholic Steatohepatitis | TLR4 mRNA levels were significantly increased in subjects with NASH compared wit... | BeFree | 26113297 | Detail |
| 0.001 | Ischemic Cerebrovascular Accident | NA | BeFree | Detail | |
| <0.001 | Juvenile arthritis | NA | BeFree | Detail | |
| <0.001 | Allergic disposition | NA | BeFree | Detail | |
| 0.001 | Allergic sensitization | NA | BeFree | Detail | |
| 0.043 | Infection | NA | GAD,LHGDN | Detail | |
| <0.001 | juvenile rheumatoid arthritis | NA | BeFree | Detail | |
| <0.001 | Disorder of Achilles tendon | NA | BeFree | Detail | |
| 0.080 | Acute-On-Chronic Liver Failure | NA | RGD | Detail | |
| 0.080 | Acanthamoeba Keratitis | NA | BeFree,RGD | Detail | |
| <0.001 | Acne Vulgaris | NA | BeFree | Detail | |
| <0.001 | Acute alcoholic liver disease | Circulating levels of endotoxin in plasma from patients with AAH caused over exp... | BeFree | 25479137 | Detail |
| 0.004 | acute pancreatitis | Toll-like receptor 4 polymorphisms to determine acute pancreatitis susceptibilit... | BeFree,GAD | 24914392 | Detail |
| 0.004 | acute pancreatitis | Effect of lornoxicam therapy on expression of TLR2 and TLR4 mRNA during systemic... | BeFree,GAD | 25403387 | Detail |
| 0.006 | adenocarcinoma | NA | BeFree,GAD,LHGDN | Detail | |
| 0.058 | asthma | The TLR4 single-nucleotide polymorphisms rs1927911, rs10759931, and rs6478317 mo... | BeFree | 24243740 | Detail |
| <0.001 | adenoma | NA | BeFree | Detail | |
| 0.005 | Albuminuria | NA | GAD | Detail | |
| <0.001 | Alcoholic Intoxication, Chronic | NA | BeFree | Detail | |
| 0.002 | Alveolar Bone Loss | NA | GAD | Detail | |
| 0.008 | Alzheimer's disease | This study shows that 24-hydroxycholesterol, 27-hydroxycholesterol, and 7β-hydro... | BeFree,GAD,LHGDN | 24802026 | Detail |
| 0.003 | amyloidosis | NA | BeFree,GAD | Detail | |
| 0.003 | anemia | NA | BeFree,LHGDN | Detail | |
| 0.006 | Angina, Unstable | NA | BeFree,LHGDN | Detail | |
| 0.005 | Anoxia | NA | LHGDN | Detail | |
| 0.002 | Anus Diseases | NA | GAD | Detail | |
| <0.001 | Arterial Occlusive Diseases | NA | BeFree | Detail | |
| 0.013 | arteriosclerosis | The results of our in silico analysis in vitro provide potential evidence that S... | BeFree | 25196434 | Detail |
| 0.013 | arteriosclerosis | Taken together, our results indicate that LPS up-regulates LOX-1, at least in pa... | BeFree | 25348362 | Detail |
| 0.013 | arteriosclerosis | STAT1-dependent signal integration between IFNγ and TLR4 in vascular cells refle... | BeFree | 25478796 | Detail |
| 0.013 | arteriosclerosis | Fibronectin Splicing Variants Containing Extra Domain A Promote Atherosclerosis ... | BeFree | 26427793 | Detail |
| 0.007 | arthritis | NA | BeFree,GAD,LHGDN | Detail | |
| <0.001 | Arthritis, Gouty | NA | BeFree | Detail | |
| <0.001 | Arthritis, Psoriatic | C-reactive protein gene and Toll-like receptor 4 gene polymorphisms can relate t... | BeFree | 24696367 | Detail |
| 0.005 | aspergillosis | NA | BeFree,GAD | Detail | |
| 0.002 | Aspergillosis, Allergic Bronchopulmonary | NA | GAD | Detail | |
| 0.158 | atherosclerosis | The results of our in silico analysis in vitro provide potential evidence that S... | BeFree,CTD_human,GAD,LHGDN | 25196434 | Detail |
| 0.158 | atherosclerosis | Taken together, our results indicate that LPS up-regulates LOX-1, at least in pa... | BeFree,CTD_human,GAD,LHGDN | 25348362 | Detail |
| 0.158 | atherosclerosis | STAT1-dependent signal integration between IFNγ and TLR4 in vascular cells refle... | BeFree,CTD_human,GAD,LHGDN | 25478796 | Detail |
| 0.158 | atherosclerosis | Fibronectin Splicing Variants Containing Extra Domain A Promote Atherosclerosis ... | BeFree,CTD_human,GAD,LHGDN | 26427793 | Detail |
| 0.006 | Autoimmune Diseases | TLR2 and TLR4 in autoimmune diseases: a comprehensive review. | BeFree,GAD,LHGDN | 24352680 | Detail |
| 0.010 | Bacteremia | NA | BeFree,GAD | Detail | |
| 0.012 | Bacterial Infections | Moreover, we observed that expression of TLR2 and TLR4 was significantly higher ... | BeFree,GAD,LHGDN | 25412934 | Detail |
| 0.012 | Bacterial Infections | Taken together, the current study suggests the importance of bacterial infection... | BeFree,GAD,LHGDN | 25833062 | Detail |
| 0.007 | bacteriuria | NA | GAD,LHGDN | Detail | |
| 0.002 | Mental disorders | NA | GAD | Detail | |
| 0.134 | Behcet Syndrome | The expression of unusual splice variants of TLR2 and TLR4 might explain the obs... | BeFree,GAD,LHGDN,ORPHANET | 23940075 | Detail |
| 0.134 | Behcet Syndrome | The expression levels of PDCD4, RhoB, PD-1, IL-12p35, and toll-like receptor-4 w... | BeFree,GAD,LHGDN,ORPHANET | 25849652 | Detail |
| 0.003 | bipolar disorder | Here we investigated the potential interaction between genetic variants of Toll-... | BeFree,GAD | 25790282 | Detail |
| 0.007 | Malignant neoplasm of urinary bladder | Toll-like receptor 4 gene polymorphism downregulates gene expression and involve... | BeFree,GAD | 25472584 | Detail |
| 0.007 | Malignant neoplasm of urinary bladder | Our findings demonstrate that bladder cancer cell lines express functional TLR4 ... | BeFree,GAD | 25499923 | Detail |
| 0.003 | Bladder Neoplasm | NA | LHGDN | Detail | |
| <0.001 | Blood Coagulation Disorders | NA | BeFree | Detail | |
| <0.001 | borderline personality disorder | NA | BeFree | Detail | |
| 0.003 | boutonneuse fever | NA | BeFree,GAD | Detail | |
| <0.001 | Brain Abscess | NA | BeFree | Detail | |
| <0.001 | Brain Diseases | NA | BeFree | Detail | |
| 0.006 | bronchiolitis | NA | BeFree,GAD | Detail | |
| 0.003 | bronchiolitis obliterans | NA | BeFree,GAD | Detail | |
| 0.007 | Bronchiolitis, Viral | NA | GAD | Detail | |
| <0.001 | bronchopulmonary dysplasia | NA | BeFree | Detail | |
| 0.006 | brucellosis | NA | BeFree,GAD,LHGDN | Detail | |
| <0.001 | Cachexia | NA | BeFree | Detail | |
| 0.002 | Campylobacter infection | NA | GAD | Detail | |
| 0.002 | candidiasis | NA | GAD | Detail | |
| 0.002 | oral candidiasis | NA | GAD | Detail | |
| 0.001 | Malignant tumor of colon | Expression of TLR2 and TLR4 receptor proteins on colon cancer cells were confirm... | BeFree | 24390484 | Detail |
| 0.001 | Malignant tumor of colon | A novel inflammatory regulator TIPE2 inhibits TLR4-mediated development of colon... | BeFree | 24934366 | Detail |
| <0.001 | Adenocarcinoma of prostate | NA | BeFree | Detail | |
| <0.001 | Rectal Carcinoma | NA | BeFree | Detail | |
| <0.001 | Non-small cell lung carcinoma | NA | BeFree | Detail |
Annotation
Annotations
| Descrption | Source | Links |
|---|---|---|
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Cancer-derived immunoglobulin G promotes LPS-induced proinflammatory cytokine production via binding... | DisGeNET | Detail |
| However, the C/C genotype for the TLR3 (c.1377 C>T) polymorphism and the Asp/Asp genotype and the As... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| For the first time, results from our study indicate defective trafficking of TLR-2 and TLR-4 contrib... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Microarray analysis showed significant upregulation for NOD2, not for NOD1, TLR2, or TLR4 in cholest... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Immune responses to human factor IX in haemophilia B mice of different genetic backgrounds are disti... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| In this study, we investigated the involvement of NO production in activation of the TLR4/NF-κB sign... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Association between Toll-like receptor 4 and interleukin 17 gene polymorphisms and colorectal cancer... | DisGeNET | Detail |
| Polymorphisms in NFKB1 and TLR4 and interaction with dietary and life style factors in relation to c... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| The expression of TLR4 and TLR3 closely correlated with the severity of coronary artery disease as r... | DisGeNET | Detail |
| Activation of liver X receptor improves viability of adipose-derived mesenchymal stem cells to atten... | DisGeNET | Detail |
| Circulating Toll-like receptor 4-responsive microRNA panel in patients with coronary artery disease:... | DisGeNET | Detail |
| The effect of genetic polymorphisms of TLR2 and TLR4 in Turkish patients with coronary artery diseas... | DisGeNET | Detail |
| The expression of TLR4 and TLR3 closely correlated with the severity of coronary artery disease as r... | DisGeNET | Detail |
| Circulating Toll-like receptor 4-responsive microRNA panel in patients with coronary artery disease:... | DisGeNET | Detail |
| The effect of genetic polymorphisms of TLR2 and TLR4 in Turkish patients with coronary artery diseas... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| TLR2 and TLR4 risk genotype carrier state and history of childhood emotional, physical and sexual ab... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| TLR4 and TLR3, two potent inducers of autophagy, were highly increased in IIM, with TLR4 transcripts... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Enhanced glomerular Toll-like receptor 4 expression and signaling in patients with type 2 diabetic n... | DisGeNET | Detail |
| Our study suggests that curcumin treatment ameliorates DN via inhibition of inflammatory gene expres... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Collectively, our novel data suggest that hyperglycemia induces TLR-2 and TLR-4 activation and downs... | DisGeNET | Detail |
| The association between toll-like receptor 4 polymorphisms and diabetic retinopathy in Chinese patie... | DisGeNET | Detail |
| Toll-like receptor 4 ablation in mdx mice reveals innate immunity as a therapeutic target in Duchenn... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Surprisingly, B. cereus-infected TLR4(-/-) eyes also had significantly less intraocular inflammation... | DisGeNET | Detail |
| TLR4-deficient mice challenged with either OVA preparation showed eosinophilia but not neutrophilia ... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| A decreased risk of GC was observed in H. pylori negative and TLR4-2081(AG+AA) genotype subjects [H.... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Patients with TLR4 polymorphisms had a higher incidence of previous hepatic encephalopathy than wild... | DisGeNET | Detail |
| Toll-like receptor 4 and hepatitis B infection: molecular mechanisms and pathogenesis. | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| The association of toll-like receptor 4 polymorphism with hepatitis C virus infection in Saudi Arabi... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| HIV Tat acts on endogenous retroviruses of the W family and this occurs via Toll-like receptor 4: in... | DisGeNET | Detail |
| Furthermore, neutrophils from HESN challenged with HIV-1 and stimulated with TLR2 and TLR4 agonists,... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Collectively, our novel data suggest that hyperglycemia induces TLR-2 and TLR-4 activation and downs... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Animal study proved that HMGB1 contributed to the pathogenesis of experimental pulmonary hypertensio... | DisGeNET | Detail |
| TLR4 D299 G showed an inverse association with pulmonary hypertension. | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Polymorphisms in the inflammatory pathway genes TLR2, TLR4, TLR9, LY96, NFKBIA, NFKB1, TNFA, TNFRSF1... | DisGeNET | Detail |
| The meta-analysis provides evidence that TLR4 polymorphisms confer a significant increased risk for ... | DisGeNET | Detail |
| Pharmacological inhibitors of TLR4 (E5564) exerted similar effects like those determined for NAC in ... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Targeting the HMGB1-TLR4 pathway might enable development of a new therapeutic strategy to improve t... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Association of gene variants in TLR4 and IL-6 genes with Perthes disease. | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| L. donovani increases the expression of TLR4 and TLR9 in patients with VL and TLR2 in THP1 cells, su... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Toll-like receptor 4 and 9 expression in B-chronic lymphocytic leukemia: relationship with infection... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Moreover, we observed that expression of TLR2 and TLR4 was significantly higher in patients with AML... | DisGeNET | Detail |
| Polymorphisms of Toll-like receptors (TLR2 and TLR4) are associated with the risk of infectious comp... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Therefore, the aim of this review is to present the recent data regarding the important roles of TLR... | DisGeNET | Detail |
| Cytokine production in patients with cirrhosis and TLR4 polymorphisms. | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| In the present study, we investigated whether variants in the TLR-1 1805T/G (Ile602Ser), TLR-2 2258G... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Association of TLR4 (D299G, T399I), TLR9 -1486T>C, TIRAP S180L and TNF-α promoter (-1031, -863, -857... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| TLR4 signaling may contribute to melanoma progression, and caution should be exercised when using TL... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| We observed that TLR4 stimulation led to a more pronounced Teff activatory status, suggesting that T... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| We speculated that cross-talk occurs between TREM-1 and Toll-like receptor-4 (TLR-4) in cornea funga... | DisGeNET | Detail |
| Moreover, we observed that expression of TLR2 and TLR4 was significantly higher in patients with AML... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| These findings indicated that TLR4 may participate in the progression and metastasis of human breast... | DisGeNET | Detail |
| In our study, two HCC cell lines and a splenic vein metastasis of the nude mouse model were used to ... | DisGeNET | Detail |
| This study shows that TLR4, IL17A/F and IL23R polymorphisms are involved in the presentation of the ... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| In order to investigate this, we studied TLR4 gene and protein expression and TLR4 downward signalin... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Immune cell Toll-like receptor 4 mediates the development of obesity- and endotoxemia-associated adi... | DisGeNET | Detail |
| Thus, we evaluated the association of 17 single-nucleotide polymorphisms (SNPs) in immune response g... | DisGeNET | Detail |
| However, a high-fat diet activates TLR-2s, and obesity activates TLR-4s and induces spontaneous incr... | DisGeNET | Detail |
| Interestingly, NF-κB activity assays showed obese donor hepatocytes were resistant to chemical TLR4 ... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Here, we report increases in toll-like receptors 2 and 4 expression in circulating monocytes and of ... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Polymorphism of the CD14 and TLR4 genes and post-treatment apical periodontitis. | DisGeNET | Detail |
| TLR2 and TLR4 gene expression levels and associated factors during acute attack and attack-free peri... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| TLR4 immunoreactivity was found in healthy gingival epithelium and periodontitis tissue, and appeare... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Two independent populations of infants with RSV bronchiolitis revealed that the severity of RSV infe... | DisGeNET | Detail |
| Genetic Polymorphisms of Toll-like Receptor 4 are Associated with Respiratory Syncytial Virus Infect... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| TLR 4 T399I and TLR9 -1486 T>C showed a positive association with seizures and photosensitivity, res... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Whole body hyperthermia treatment increases interleukin 10 and toll-like receptor 4 expression in pa... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Associations of a TLR4 single-nucleotide polymorphism with H. pylori associated gastric diseases in ... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| In particular, decreased expression of let-7i, a tumor suppressor miRNA, was found to be associated ... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Surprisingly, B. cereus-infected TLR4(-/-) eyes also had significantly less intraocular inflammation... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| The association of toll-like receptor 4 polymorphism with hepatitis C virus infection in Saudi Arabi... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| The ability of PGA to induce TNF-α and IL-6 was retained in TLR4(-/-) but not TLR2(-/-) BMDMs. | DisGeNET | Detail |
| Toll-like receptor 4 polymorphisms in gram-negative bacterial infections of Han Chinese neonates. | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Co-localization between autophagic marker, LC3, and TLR4 and TLR3 was observed not only in sIBM but ... | DisGeNET | Detail |
| We especially observed that mRNA expression of TLR2 and TLR4 was significantly higher in patients wi... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Activation of liver X receptor improves viability of adipose-derived mesenchymal stem cells to atten... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Association of TLR2, TLR3, TLR4 and CD14 genes polymorphisms with oral cancer risk and survival. | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Thus, TLR4 pathway should seem to have a key role in sporadic TAA. | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Paclitaxel, a known TLR4 ligand, leads to activation of TLR4/MyD88-dependent pathway that mediates c... | DisGeNET | Detail |
| Our findings demonstrate that bladder cancer cell lines express functional TLR4 and TLR9 with possib... | DisGeNET | Detail |
| Toll like receptor 4 (TLR4), acting as a receptor for lipopolysaccharide (LPS), has been reported to... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Toll-like receptor-4 is a target for suppression of proliferation and chemoresistance in HepG2 hepat... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Association of TLR2, TLR3, TLR4 and CD14 genes polymorphisms with oral cancer risk and survival. | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| TLR4 and TLR3, two potent inducers of autophagy, were highly increased in IIM, with TLR4 transcripts... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| LPS-induced monocyte TLR-4 was increased significantly in infants with NE on day 7. | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| ACAT1-deficient and wild-type mice, or Toll-like receptor 4 (TLR4)(-/-)ACAT1(+/+) and TLR4(-/-)ACAT1... | DisGeNET | Detail |
| A recent study reported that TLR4 gene polymorphisms are good prognostic predictors and are associat... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| The expression of TLR4 and TLR3 closely correlated with the severity of coronary artery disease as r... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Furthermore, using data generated by The Cancer Genome Atlas consortium, we demonstrate that the eff... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Co-localization between autophagic marker, LC3, and TLR4 and TLR3 was observed not only in sIBM but ... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| The role of TLR4 and CD14 polymorphisms in the pathogenesis of respiratory syncytial virus bronchiol... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| TLR2 and TLR4 risk genotype carrier state and history of childhood emotional, physical and sexual ab... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Cancer-derived immunoglobulin G promotes LPS-induced proinflammatory cytokine production via binding... | DisGeNET | Detail |
| However, the C/C genotype for the TLR3 (c.1377 C>T) polymorphism and the Asp/Asp genotype and the As... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Both in microalbuminuria and in overt DN, TLR4 mRNA and protein were overexpressed 4- to 10-fold in ... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| TLR2 and TLR4 risk genotype carrier state and history of childhood emotional, physical and sexual ab... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| The role of TLR4 in the pathophysiology of several age-related diseases is also well recognized, suc... | DisGeNET | Detail |
| TLR4 activation by lipopolysaccharide confers survival advantage to growth factor deprived prostate ... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Toll-like receptor-4 in human and mouse colonic epithelium is developmentally regulated: a possible ... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| The tlr-4 (D299G and T399I), tlr-9 (T-1486C and T-1237C) and tirap (S180L) genes were assessed in 64... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| The TLR4-2081G/A polymorphism seems to affect the risk of gastric carcinogenesis and may to some deg... | DisGeNET | Detail |
| Stimulation of TLR4 with LPS promoted tumorigenesis and formed metastatic lesions in liver of nude m... | DisGeNET | Detail |
| AP reduced AOM/DSS-associated toxicities, prevented carcinogenesis, and decreased the expression of ... | DisGeNET | Detail |
| Toll like receptor 4 (TLR4), acting as a receptor for lipopolysaccharide (LPS), has been reported to... | DisGeNET | Detail |
| The role of TLR4 in the pathophysiology of several age-related diseases is also well recognized, suc... | DisGeNET | Detail |
| TLR4 activation by lipopolysaccharide confers survival advantage to growth factor deprived prostate ... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Therefore, AO-I could significantly sensitize the response of MyD88(+) EOC cells to paclitaxel by bl... | DisGeNET | Detail |
| Our data thus suggest that NF-κB signaling is important for maintenance of cisplatin resistance but ... | DisGeNET | Detail |
| Furthermore, using data generated by The Cancer Genome Atlas consortium, we demonstrate that the eff... | DisGeNET | Detail |
| Toll-like receptor 4 prompts human breast cancer cells invasiveness via lipopolysaccharide stimulati... | DisGeNET | Detail |
| In addition, TLR4 A299G polymorphism was also associated with community-acquired pneumonia (CAP) ris... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Expression of TLR2 and TLR4 receptor proteins on colon cancer cells were confirmed by immunohistoche... | DisGeNET | Detail |
| A novel inflammatory regulator TIPE2 inhibits TLR4-mediated development of colon cancer via caspase-... | DisGeNET | Detail |
| Toll-like receptor 4 gene polymorphism downregulates gene expression and involves in susceptibility ... | DisGeNET | Detail |
| Our findings demonstrate that bladder cancer cell lines express functional TLR4 and TLR9 with possib... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Enhanced glomerular Toll-like receptor 4 expression and signaling in patients with type 2 diabetic n... | DisGeNET | Detail |
| Using a middle cerebral artery occlusion (MCAO) model, triphenyltetrazolium chloride staining was ut... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| We retrospectively assessed incidence of SBIs in 336 adult ESLD patients enlisted for orthotopic liv... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| The results of our in silico analysis in vitro provide potential evidence that STAT1-dependent IFNγ-... | DisGeNET | Detail |
| Co-localization between autophagic marker, LC3, and TLR4 and TLR3 was observed not only in sIBM but ... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| High mobility group box 1 (HMGB1), a recently discovered potent pro-inflammatory cytokine, plays an ... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Emerging studies have focused on the effect of isoflurane (ISO) pretreatment on cerebral ischemia, h... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Thus, an enhanced HMGB1-TLR4 pathway contributes to lung injury induced by bilateral nephrectomy and... | DisGeNET | Detail |
| The protective effect on renal ischemia reperfusion injury Is mediated by IgM ALA as protection was ... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Studies suggest that in addition to effects of cell free plasma hemoglobin on scavenging nitric oxid... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| TLR3 and TLR4 are known to act as anti-inflammatory and pro-inflammatory factors respectively in mul... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| TLR4-deficient mice challenged with either OVA preparation showed eosinophilia but not neutrophilia ... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| TLR4 ligands have received attention as immunotherapies; therefore, we assessed the expression of TL... | DisGeNET | Detail |
| Association of gene variants in TLR4 and IL-6 genes with Perthes disease. | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| This study identifies a novel dichotomous role for TLR4 as a growth regulator and a modulator of tum... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Association between Toll-like receptor 4 and interleukin 17 gene polymorphisms and colorectal cancer... | DisGeNET | Detail |
| Polymorphisms in NFKB1 and TLR4 and interaction with dietary and life style factors in relation to c... | DisGeNET | Detail |
| Using a middle cerebral artery occlusion (MCAO) model, triphenyltetrazolium chloride staining was ut... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Therefore, the aim of this review is to present the recent data regarding the important roles of TLR... | DisGeNET | Detail |
| Cytokine production in patients with cirrhosis and TLR4 polymorphisms. | DisGeNET | Detail |
| Both in microalbuminuria and in overt DN, TLR4 mRNA and protein were overexpressed 4- to 10-fold in ... | DisGeNET | Detail |
| TLR4-deficient mice challenged with either OVA preparation showed eosinophilia but not neutrophilia ... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| In order to investigate this, we studied TLR4 gene and protein expression and TLR4 downward signalin... | DisGeNET | Detail |
| Our aim is to study a transcriptional activation pathway of the innate immune system through the cel... | DisGeNET | Detail |
| Unexpected Roles for Toll-Like Receptor 4 and TRIF in Intraocular Infection with Gram-Positive Bacte... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| TLR 4 T399I and TLR9 -1486 T>C showed a positive association with seizures and photosensitivity, res... | DisGeNET | Detail |
| TLR3 and TLR4 as potential clinically biomarkers of cardiovascular risk in coronary artery disease (... | DisGeNET | Detail |
| Circulating Toll-like receptor 4-responsive microRNA panel in patients with coronary artery disease:... | DisGeNET | Detail |
| The effect of genetic polymorphisms of TLR2 and TLR4 in Turkish patients with coronary artery diseas... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Therefore, the aim of this review is to present the recent data regarding the important roles of TLR... | DisGeNET | Detail |
| A functional variant at miR-34a binding site in toll-like receptor 4 gene alters susceptibility to h... | DisGeNET | Detail |
| Toll like receptor 4 facilitates invasion and migration as a cancer stem cell marker in hepatocellul... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Toll-like receptor 4 (TLR4), a component of the innate immune system, is recognized to promote tubul... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Co-localization between autophagic marker, LC3, and TLR4 and TLR3 was observed not only in sIBM but ... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| TLR4 mRNA levels were significantly increased in subjects with NASH compared with NAFL as was interf... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Circulating levels of endotoxin in plasma from patients with AAH caused over expression of immune in... | DisGeNET | Detail |
| Toll-like receptor 4 polymorphisms to determine acute pancreatitis susceptibility and severity: a me... | DisGeNET | Detail |
| Effect of lornoxicam therapy on expression of TLR2 and TLR4 mRNA during systemic complications of ac... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| The TLR4 single-nucleotide polymorphisms rs1927911, rs10759931, and rs6478317 modified the associati... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| This study shows that 24-hydroxycholesterol, 27-hydroxycholesterol, and 7β-hydroxycholesterol, the t... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| The results of our in silico analysis in vitro provide potential evidence that STAT1-dependent IFNγ-... | DisGeNET | Detail |
| Taken together, our results indicate that LPS up-regulates LOX-1, at least in part through activatio... | DisGeNET | Detail |
| STAT1-dependent signal integration between IFNγ and TLR4 in vascular cells reflect pro-atherogenic r... | DisGeNET | Detail |
| Fibronectin Splicing Variants Containing Extra Domain A Promote Atherosclerosis in Mice Through Toll... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| C-reactive protein gene and Toll-like receptor 4 gene polymorphisms can relate to the development of... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| The results of our in silico analysis in vitro provide potential evidence that STAT1-dependent IFNγ-... | DisGeNET | Detail |
| Taken together, our results indicate that LPS up-regulates LOX-1, at least in part through activatio... | DisGeNET | Detail |
| STAT1-dependent signal integration between IFNγ and TLR4 in vascular cells reflect pro-atherogenic r... | DisGeNET | Detail |
| Fibronectin Splicing Variants Containing Extra Domain A Promote Atherosclerosis in Mice Through Toll... | DisGeNET | Detail |
| TLR2 and TLR4 in autoimmune diseases: a comprehensive review. | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Moreover, we observed that expression of TLR2 and TLR4 was significantly higher in patients with AML... | DisGeNET | Detail |
| Taken together, the current study suggests the importance of bacterial infection or TLR4-activation ... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| The expression of unusual splice variants of TLR2 and TLR4 might explain the observed defect in thes... | DisGeNET | Detail |
| The expression levels of PDCD4, RhoB, PD-1, IL-12p35, and toll-like receptor-4 were also regulated b... | DisGeNET | Detail |
| Here we investigated the potential interaction between genetic variants of Toll-like receptors 2 (TL... | DisGeNET | Detail |
| Toll-like receptor 4 gene polymorphism downregulates gene expression and involves in susceptibility ... | DisGeNET | Detail |
| Our findings demonstrate that bladder cancer cell lines express functional TLR4 and TLR9 with possib... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Expression of TLR2 and TLR4 receptor proteins on colon cancer cells were confirmed by immunohistoche... | DisGeNET | Detail |
| A novel inflammatory regulator TIPE2 inhibits TLR4-mediated development of colon cancer via caspase-... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
Overlapped Transcript Coordinates
| Gene | Transcript ID | Exon Number | Chromosome | Start | Stop | Type | Amino Mutation | Transcript Position | Links |
|---|
Overlapped Transcript
| Gene | Transcript ID | Chromosome | Start | Stop | Links |
|---|
- Gene
- -
- dbSNP
- rs386502799 dbSNP
- Genome
- hg38
- Position
- chr9:117,704,175-117,724,735
- Variant Type
- snv
Genome browser