invasive aspergillosis
Information
- Disease name
- invasive aspergillosis
- Disease ID
- DOID:0050073
- Description
- "An aspergillosis that is a serious fungal infection of the lung with pneumonia caused by Aspergillus, which spreads to other parts of the body through bloodstream in patients with acute leukemia and recipients of tissue transplants. Clinical symptoms include pulmonary nodules and hemorrhage." [url:http\://www.merck.com/mmhe/sec17/ch197/ch197b.html?qt=invasive%20pulmonary%20aspergillosis&alt=sh, url:http\://www.nlm.nih.gov/medlineplus/ency/article/001326.htm]
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
| Genes | Mutation | Description | Source | Links |
|---|
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT02737371 | Completed | Phase 1 | Multiple Ascending Oral Dose Study of F901318 in Healthy Subjects | May 2016 | May 22, 2017 |
| NCT02730442 | Completed | Phase 1 | Study of Potential for Interaction of Fluconazole With F901318 | February 2016 | June 2016 |
| NCT00334412 | Completed | Phase 4 | COMBISTRAT: AmBisome® in Combination With Caspofungin for the Treatment of Invasive Aspergillosis | March 2004 | May 2006 |
| NCT02680808 | Completed | Phase 1 | Evaluation of the Potential for Cytochrome P450 3A4 Inhibition by F901318 Using Oral Midazolam as a Probe | January 2016 | June 2016 |
| NCT00404092 | Completed | Phase 2 | Caspofungin Maximum Tolerated Dose in Patients With Invasive Aspergillosis | October 2006 | October 2009 |
| NCT00816088 | Completed | Diagnostic and Management Strategies for Invasive Aspergillosis | December 2008 | December 2011 | |
| NCT04550936 | Completed | Patterns of Real-World Isavuconazole Use - a Study of Patients With Mucormycosis or Invasive Aspergillosis | March 10, 2021 | December 23, 2023 | |
| NCT04218851 | Completed | Phase 2 | Posaconazole (MK-5592) Intravenous and Oral in Children With Invasive Aspergillosis (IA) (MK-5592-104) | July 2, 2020 | December 18, 2023 |
| NCT03816176 | Completed | Phase 2 | A Study to Evaluate Isavuconazonium Sulfate for the Treatment of Invasive Aspergillosis (IA) or Invasive Mucormycosis (IM) in Pediatric Participants | August 22, 2019 | December 14, 2022 |
| NCT00158730 | Completed | Phase 3 | Study Safety/Efficacy of AmBisome Loading Dose Regimen Versus Standard AmBisome Regimen for Initial Treatment | April 2003 | January 2005 |
| NCT01080651 | Completed | Phase 1 | Influence of Drug-drug Interactions on the Pharmacokinetics (PK) of Voriconazole | December 2008 | March 2009 |
| NCT01128907 | Completed | Galactomannan Antigen in Bronchoalveolar Lavage in the Diagnosis of Invasive Aspergillosis in Neutropenic Patients | October 2006 | December 2012 | |
| NCT03340597 | Completed | Phase 1 | Assessment of Varying Oral Dosing Regimens for F901318 in Healthy Subjects | December 12, 2017 | April 13, 2018 |
| NCT00163722 | Completed | Phase 3 | A Multicentre Randomised Controlled Trial Comparing Two Strategies for the Diagnosis of Invasive Aspergillosis in High-risk Haematology Patients | September 2005 | August 2011 |
| NCT01430663 | Completed | Diagnosing Pulmonary Aspergillosis in Patients With Hematological Malignancies: A Multicentre Prospective Evaluation of an Aspergillus PCR Assay and a Galactomannan ELISA in Bronchoalveolar Lavage Samples | April 2007 | February 2011 | |
| NCT01448226 | Completed | Diagnosing Invasive Aspergillosis by Polymerase Chain Reaction (PCR) Based Investigation of Bronchoalveolar Lavage Samples During Antifungal Therapy | January 2000 | May 2011 | |
| NCT03221075 | Completed | Clinical Implications of Azole-Resistant Aspergillosis in Hematological Malignancy | March 1, 2017 | October 25, 2022 | |
| NCT03067350 | Completed | Influence of a Combined Pharmacogenetic Score on Through Plasma Voriconazole Concentrations in Haematological Patients | January 2015 | January 2019 | |
| NCT02900430 | Completed | Invasives Aspergillosis in Acute Myeloid Leukemia | January 2009 | December 2015 | |
| NCT02106117 | Completed | Exhaled Breath Analysis in the Early Detection of Aspergillosis | December 2012 | March 2017 | |
| NCT02142153 | Completed | Phase 1 | F901318 Single Ascending Dose Study in Healthy Male Volunteers | August 2014 | October 2014 |
| NCT02342574 | Completed | Phase 1 | F901318 Multiple Ascending Dose Study | February 2015 | September 2016 |
| NCT02394483 | Completed | Phase 1 | Single Ascending Oral Dose Study of F901318 | October 2015 | September 2016 |
| NCT02808741 | Completed | Phase 1 | Evaluation of Immediate Release Tablet | July 2016 | November 2016 |
| NCT05707832 | Not yet recruiting | Phase 3 | A Study of ABCD for Injection in Subjects With Invasive Candidiasis and Invasive Aspergillus | March 30, 2023 | December 15, 2025 |
| NCT03717623 | Recruiting | Phase 4 | Posaconazole Pharmacokinetics in Patients Receiving Chemotherapy or Stem Cell Transplants | August 1, 2019 | December 30, 2023 |
| NCT01386437 | Recruiting | Natural History of Individuals With Immune System Problems That Lead to Fungal Infections | November 5, 2012 | ||
| NCT05101187 | Recruiting | Phase 3 | Olorofim Aspergillus Infection Study | March 31, 2022 | November 1, 2026 |
| NCT06028451 | Recruiting | ManagemEnt of Antifungal Drug in Invasive Aspergillosis：a Real-word Study | September 25, 2023 | December 15, 2024 | |
| NCT06069505 | Recruiting | Detection of Azole Resistance Inducing Mutations on DNA Extracted Directly From Serum or Plasma of Immunocompromised Patients With an Invasive Aspergillus Infection Azole Resistance PCR Optimalization-study | July 1, 2017 | December 31, 2030 | |
| NCT06344117 | Recruiting | Assessment of Volatile Organic Compounds (VOC) for the Diagnosis of Invasive Aspergillosis (IA) in Lung Transplant Recipients | December 12, 2023 | December 2025 | |
| NCT06382922 | Recruiting | Role of Antifungal Prophylaxis in Elderly Patients With Acute Myeloid Leukemia During Consolidation Therapy | March 29, 2023 | June 1, 2025 | |
| NCT02396225 | Terminated | N/A | Concentrations of Voriconazole in Blood and BAL-fluid After Inhalation and Oral Administration | March 2015 | December 2016 |
| NCT03327727 | Terminated | Phase 2 | VL-2397 Compared to Standard First-Line Treatment for Invasive Aspergillosis (IA) in Adults | February 20, 2018 | January 14, 2019 |
| NCT02646774 | Terminated | Phase 4 | Post Marketing Study to Evaluate the Efficacy and Safety of Micafungin Treatment on Invasive Aspergillosis | March 1, 2014 | June 26, 2015 |
| NCT00982540 | Terminated | N/A | Validation of an Index of Neutropenia (D-index) in Febrile Neutropenic Cancer Patients | February 2010 | December 2013 |
| NCT00836875 | Terminated | Phase 3 | A Study To Evaluate The Safety Of Voriconazole As Treatment Of Invasive Aspergillosis (Fungal Infection) And Other Rare Molds In Children | May 2009 | May 2013 |
| NCT04876716 | Terminated | Phase 3 | Azole-echinocandin Combination Therapy for Invasive Aspergillosis | May 11, 2021 | May 1, 2024 |
| NCT00376337 | Terminated | Phase 2 | Micafungin Salvage Mono-therapy in Invasive Aspergillosis | June 2006 | September 2008 |
| NCT04486885 | Unknown status | European Study of Cerebral Aspergillosis Treated With Isavuconazole | August 1, 2021 | March 1, 2023 | |
| NCT03014934 | Unknown status | Impact of Pre-existing Invasive Aspergillosis on Allogeneic Stem Cell Transplantation | January 2016 | December 2021 | |
| NCT01695512 | Unknown status | Diagnostic Study of Combined Biomnarker Testing in Bronchoalveolar Lavage Samples of Immunocompromised Patients | August 2012 | December 2020 | |
| NCT01695499 | Unknown status | Diagnostic Study of Biomarkers in BAL of ICU Patients With Lung Infiltrates | August 2012 | December 2020 | |
| NCT01176071 | Unknown status | Correlation Between Circulating Galactomannan and Beta-D-glucan and Clinical Outcome of Invasive Aspergillosis | July 2010 | January 2011 | |
| NCT00843804 | Unknown status | Surveillance for Nosocomial Infections in Pediatric Cancer Patients | March 2007 | June 2010 | |
| NCT00838643 | Unknown status | Invasive Aspergillosis After Allogeneic Hematopoietic Stem Cell Transplantation (HSCT) | May 2002 | December 2009 | |
| NCT04225195 | Unknown status | Phase 2 | Amphotericin B Cholesteryl Sulfate Complex for Injection(ABCD) in the Treatment of Invasive Candidiasis and Invasive Aspergillosis | January 2020 | June 2022 |
| NCT02773342 | Unknown status | An Evaluation of Sequential Computed Tomography of the Chest in Management of Invasive Pulmonal Aspergillosis in Neutropenic Patients With Haematological Malignancies | June 2013 | ||
| NCT02104479 | Unknown status | Diagnostic Accuracy of Pleural Effusion Aspergillosis Biomarker Testing | March 31, 2014 | December 31, 2020 | |
| NCT03076905 | Withdrawn | Phase 1 | Pharmacokinetics of IV Formulation | May 2017 | August 2017 |
| NCT03095547 | Withdrawn | Phase 1 | Drug/Drug Interactions With F901318 | May 2017 | October 2017 |
| NCT02912026 | Withdrawn | Phase 1 | Radiolabelled IV and Oral Metabolism Study of F901318 | May 2019 | July 2019 |
- Disase is a (Disease Ontology)
- DOID:13564