chr2:112773925:> Detail (hg38)

Information

Genome

Assembly Position
hg19 chr2:113,531,502-113,542,070 
hg38 chr2:112,773,925-112,784,493

HGVS

Type Transcript Protein
Summary

MGeND

Clinical significance
Variant entry
GWAS entry
Disease area statistics Show details

Frequency

[No Data.]

Prediction

[No Data.]

ClinVar

Clinical Significance
Review star [No Data.]
Show details
Links
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
[No Data.]
CIViC
[No Data.]
DisGeNET
Score Disease name Description Source Pubmed Links
0.005 squamous cell carcinoma Reciprocal interaction between carcinoma-associated fibroblasts and squamous car... BeFree,GAD 25425967 Detail
0.008 Cardiovascular Diseases NA BeFree,GAD Detail
0.003 celiac disease NA BeFree,GAD Detail
0.002 cellulitis NA GAD Detail
<0.001 intracranial aneurysm NA BeFree Detail
0.003 intracranial arteriosclerosis NA LHGDN Detail
<0.001 cerebral atherosclerosis NA BeFree Detail
0.006 cerebral infarction NA BeFree,GAD Detail
0.122 brain ischemia NA CTD_human,GAD Detail
<0.001 cerebral palsy NA BeFree Detail
<0.001 Malignant tumor of cervix NA BeFree Detail
0.002 Chagas Cardiomyopathy NA GAD Detail
0.002 Chlamydia Infections NA GAD Detail
<0.001 Cholangitis, Sclerosing NA BeFree Detail
0.080 cholestasis NA RGD Detail
<0.001 cholesteatoma NA BeFree Detail
0.122 chorioamnionitis NA CTD_human,GAD Detail
<0.001 colitis NA BeFree Detail
0.005 ulcerative colitis NA BeFree,GAD Detail
0.001 colorectal carcinoma NA BeFree Detail
0.002 common variable immunodeficiency NA GAD Detail
0.002 Connective Tissue Diseases NA GAD Detail
<0.001 Contracture NA BeFree Detail
<0.001 Contracture of joint NA BeFree Detail
0.003 Febrile Convulsions NA BeFree,GAD Detail
0.001 Coronary Arteriosclerosis NA BeFree Detail
0.006 Coronary heart disease NA BeFree,GAD,LHGDN Detail
<0.001 craniosynostosis NA BeFree Detail
0.001 Crohn Disease As Th17 cytokines, such as IL-17A, and IL-1 family members, such as IL-36, play ... BeFree 25299544 Detail
0.003 cystic fibrosis NA BeFree,GAD Detail
<0.001 Multi-infarct dementia NA BeFree Detail
0.002 Presenile dementia NA BeFree Detail
<0.001 Senile dementia NA BeFree Detail
0.003 Dementia, Vascular NA BeFree,GAD Detail
0.002 Dental Fistula NA GAD Detail
0.002 Dental Occlusion, Traumatic NA GAD Detail
0.005 Dental Plaque NA BeFree,GAD Detail
0.001 Mental Depression NA BeFree Detail
0.001 depressive disorder NA BeFree Detail
0.001 dermatitis NA BeFree Detail
0.004 Dermatitis, Atopic However, there was a significant relationship between the A/A genotype in the -1... BeFree,GAD 25223230 Detail
0.005 contact dermatitis NA LHGDN Detail
0.126 dermatomyositis NA BeFree,CTD_human,GAD,LHGDN Detail
0.002 Diabetes NA BeFree Detail
0.002 diabetes mellitus NA BeFree Detail
0.080 Diabetes Mellitus, Experimental NA RGD Detail
0.012 Diabetes Mellitus, Insulin-Dependent NA BeFree,GAD Detail
0.013 Diabetes Mellitus, Non-Insulin-Dependent These data provide the first in vivo evidence—using a transgenic mouse model wit... BeFree,GAD 25491100 Detail
<0.001 Diabetic Nephropathy Oxidative stress and its association with TNF-α-308 G/C and IL-1α-889 C/T gene p... BeFree 25732517 Detail
0.120 diarrhea NA CTD_human Detail
<0.001 Down syndrome NA BeFree Detail
<0.001 Dry Eye Syndromes Primary human corneal epithelial cells (HCEC), an SV40 HCEC cell line or a norma... BeFree 25817729 Detail
<0.001 duodenal ulcer NA BeFree Detail
<0.001 Amebic colitis NA BeFree Detail
0.002 dysthymic disorder NA GAD Detail
0.001 Eczema However, there was a significant relationship between the A/A genotype in the -1... BeFree 25223230 Detail
<0.001 Experimental Autoimmune Encephalomyelitis NA BeFree Detail
<0.001 Leukoencephalitis, Acute Hemorrhagic NA BeFree Detail
0.003 endocarditis NA LHGDN Detail
0.003 Endometrial Neoplasms NA LHGDN Detail
0.009 endometriosis NA BeFree,GAD,LHGDN Detail
0.080 Enterocolitis NA RGD Detail
0.001 epilepsy NA BeFree Detail
0.003 Epilepsy, Temporal Lobe NA BeFree,GAD Detail
0.002 Equine Infectious Anemia NA GAD Detail
0.002 erythema nodosum NA GAD Detail
<0.001 Exanthema NA BeFree Detail
0.003 Fatty Liver NA LHGDN Detail
<0.001 fetal alcohol syndrome NA BeFree Detail
0.002 Fetal Diseases NA GAD Detail
0.002 Fetal Membranes, Premature Rupture NA GAD Detail
0.120 Fever NA CTD_human Detail
<0.001 Periodic fever NA BeFree Detail
<0.001 fibrosarcoma NA BeFree Detail
0.007 gastritis The data from the current study showed that the genotype IL-1B -511T/-31C-IL1-RN... BeFree,GAD,LHGDN 25292060 Detail
0.003 Gastritis, Atrophic NA BeFree,GAD Detail
<0.001 gastroesophageal reflux disease NA BeFree Detail
<0.001 Gastrointestinal Diseases NA BeFree Detail
0.009 Gingival Diseases NA BeFree Detail
0.005 Gingival Hemorrhage NA GAD Detail
0.002 Gingival Hyperplasia NA GAD Detail
0.008 gingival recession NA BeFree,GAD Detail
0.008 gingivitis NA BeFree,GAD Detail
<0.001 glaucoma NA BeFree Detail
0.005 Glaucoma, Open-Angle NA GAD Detail
0.002 glioblastoma Specifically, the ability to produce IL-1 by glioblastoma cells may confer them ... BeFree 25054228 Detail
<0.001 Glioma IL-1 also activated Stat3, a transcription factor crucial in glioma progression. BeFree 25054228 Detail
<0.001 glomerulonephritis NA BeFree Detail
0.004 IgA glomerulonephritis NA BeFree,GAD Detail
0.013 Graft-vs-Host Disease NA BeFree,GAD Detail
<0.001 chronic granulomatous disease NA BeFree Detail
0.006 Graves Disease NA BeFree,GAD Detail
0.002 Hand Dermatoses NA GAD Detail
0.003 Heart Diseases NA BeFree,GAD Detail
<0.001 Heart failure NA BeFree Detail
<0.001 congestive heart failure NA BeFree Detail
0.200 Heat Stroke NA CTD_human,RGD Detail
0.005 Hematological Disease NA GAD Detail
0.120 hemolytic-uremic syndrome NA CTD_human Detail
0.003 Hemorrhage NA LHGDN Detail
0.005 Hemorrhagic Fever with Renal Syndrome NA GAD Detail
<0.001 hepatitis NA BeFree Detail
<0.001 hepatitis A NA BeFree Detail
0.002 hepatitis B NA BeFree Detail
<0.001 Hepatitis, Chronic NA BeFree Detail
<0.001 hepatitis C NA BeFree Detail
<0.001 Histiocytosis, Langerhans-Cell MCPyV infection can trigger precursor LCH cells with BRAF mutation to produce IL... BeFree 25889448 Detail
0.021 HIV Infections NA BeFree,GAD Detail
<0.001 Hodgkin Disease NA BeFree Detail
<0.001 Huntington disease NA BeFree Detail
0.120 Hyperalgesia NA CTD_human Detail
<0.001 hypercalcemia NA BeFree Detail
<0.001 Hypercalciuria NA BeFree Detail
<0.001 Hypercholesterolemia NA BeFree Detail
0.003 hyperglycemia NA LHGDN Detail
<0.001 hyperinsulinism NA BeFree Detail
0.002 Immediate hypersensitivity NA GAD Detail
0.003 Hypertensive disease NA BeFree,GAD Detail
<0.001 pulmonary hypertension NA BeFree Detail
0.120 Hypotension NA CTD_human Detail
<0.001 Immunologic Deficiency Syndromes NA BeFree Detail
<0.001 infectious mononucleosis NA BeFree Detail
0.003 infertility NA LHGDN Detail
0.156 Inflammation NA CTD_human,GAD Detail
0.003 Inflammatory Bowel Diseases IL-1 SNPs seem to be associated with IBD and could affect the disease severity a... BeFree 25466956 Detail
<0.001 influenza NA BeFree Detail
<0.001 insulinoma NA BeFree Detail
0.005 Intervertebral Disk Displacement NA GAD Detail
0.003 irritable bowel syndrome Polymorphisms of IL-RA gene (anti-inflammatory) was evaluated in IBS and healthy... BeFree,GAD 25073651 Detail
0.001 ischemia Our data suggest that central inhibition of IL-1α or Tox3 overexpression during ... BeFree 26224856 Detail
<0.001 arthropathy NA BeFree Detail
0.120 Kearns-Sayre syndrome NA CTD_human Detail
0.003 keratoconjunctivitis sicca NA LHGDN Detail
0.003 keratoconus NA BeFree,GAD Detail
<0.001 Kidney Calculi NA BeFree Detail
<0.001 Kidney Diseases NA BeFree Detail
0.006 Kidney Failure, Chronic NA BeFree,GAD Detail
0.002 Kidney Neoplasm NA GAD Detail
0.002 Premature Obstetric Labor NA GAD Detail
<0.001 leishmaniasis NA BeFree Detail
<0.001 Leishmaniasis, Cutaneous NA BeFree Detail
0.002 leptospirosis NA GAD Detail
0.002 leukemia NA BeFree Detail
0.003 chronic lymphocytic leukemia NA BeFree,GAD Detail
<0.001 hairy cell leukemia NA BeFree Detail
<0.001 Acute Megakaryocytic Leukemias NA BeFree Detail
0.004 Leukemia, Myelocytic, Acute NA BeFree Detail
0.008 Myeloid Leukemia, Chronic NA BeFree,GAD Detail
0.001 Leukemia, T-Cell NA BeFree Detail
0.001 Adult T-Cell Lymphoma/Leukemia NA BeFree Detail
<0.001 Lichen Sclerosus et Atrophicus NA BeFree Detail
<0.001 lipodystrophy NA BeFree Detail
0.003 liver cirrhosis NA BeFree,GAD Detail
<0.001 Liver diseases NA BeFree Detail
0.003 Alcoholic Liver Diseases NA BeFree,GAD Detail
0.006 Liver neoplasms NA BeFree,GAD Detail
0.003 Low Back Pain NA BeFree,GAD Detail
0.001 Lung diseases Moreover, recent studies suggested that IL-1 participates in the progression of ... BeFree 25858413 Detail
0.002 Lung Diseases, Fungal NA GAD Detail
0.003 Chronic Obstructive Airway Disease The interleukin-1 (IL-1) gene polymorphisms have been implicated in chronic obst... BeFree,GAD 25174605 Detail
<0.001 Lupus Vulgaris NA BeFree Detail
<0.001 Lupus Erythematosus, Discoid NA BeFree Detail
0.006 Lupus Erythematosus, Systemic Meta-analysis of associations of IL1 receptor antagonist and estrogen receptor g... BeFree,GAD 25286391 Detail
0.002 Lymphocytosis NA GAD Detail
0.003 Lymphohistiocytosis, Hemophagocytic NA BeFree,LHGDN Detail
0.003 lymphoma NA BeFree,GAD Detail
0.002 Lymphoma, Non-Hodgkin NA GAD Detail
0.005 Lymphoproliferative Disorders NA BeFree,GAD Detail
<0.001 Malaria, Cerebral NA BeFree Detail
0.003 Malaria, Falciparum NA BeFree,GAD Detail
0.014 Malignant neoplasm of stomach Inflammation, especially the cytokine response of the IL-1 family, has been show... BeFree,GAD 24557417 Detail
0.014 Malignant neoplasm of stomach Moreover, the in vitro production of proangiogenic factors in response to FPR2/3... BeFree,GAD 25263443 Detail
0.002 Mandibular Diseases NA GAD Detail
0.002 Maxillary Diseases NA GAD Detail
<0.001 measles NA BeFree Detail
0.010 melanoma NA BeFree,LHGDN Detail
<0.001 melioidosis NA BeFree Detail
<0.001 Meningitis, Pneumococcal NA BeFree Detail
0.006 Meningococcal Infections NA BeFree,GAD Detail
<0.001 Mesothelioma NA BeFree Detail
<0.001 Metabolic Diseases NA BeFree Detail
<0.001 mitral valve stenosis NA BeFree Detail
<0.001 Monoclonal Gammopathy of Undetermined Significance NA BeFree Detail
<0.001 Monosomy NA BeFree Detail
0.002 Mouth Neoplasms NA GAD Detail
0.003 Mucocutaneous Lymph Node Syndrome NA BeFree,GAD Detail
0.009 multiple myeloma NA BeFree,GAD,LHGDN Detail
0.002 Multiple Organ Failure NA GAD Detail
0.008 Nasal Polyps To replicate and extend recent findings in a Turkish population of associations ... BeFree 20157068 Detail
0.013 multiple sclerosis NA BeFree,GAD Detail
<0.001 Chronic sinusitis To replicate and extend recent findings in a Turkish population of associations ... BeFree 20157068 Detail
0.002 Musculoskeletal Diseases NA GAD Detail
0.003 myasthenia gravis NA BeFree,GAD Detail
<0.001 Mycoplasma Infections NA BeFree Detail
0.005 myocardial infarction NA BeFree,GAD Detail
0.080 Myocardial Reperfusion Injury NA RGD Detail
<0.001 myositis NA BeFree Detail
0.002 narcolepsy NA GAD Detail
0.008 Nasal Polyps NA BeFree,GAD Detail
0.007 Neoplasm Metastasis These results suggest that tested SNPs associated with differential production o... BeFree,GAD,LHGDN 26753456 Detail
0.004 breast carcinoma Assuming a dominant genetic model, IL1A A114S significantly modified the dose-re... BeFree 17932347 Detail
0.018 Malignant neoplasm of breast Assuming a dominant genetic model, IL1A A114S significantly modified the dose-re... BeFree 17932347 Detail
0.002 Neoplasm Recurrence, Local NA GAD Detail
<0.001 Neoplasms, Experimental NA BeFree Detail
0.002 Pathologic Neovascularization NA GAD Detail
<0.001 nephritis NA BeFree Detail
0.004 osteoporosis Our results of the association of IL-1α gene single nucleotide polymorphisms (SN... BeFree 22868802 Detail
<0.001 nephrotic syndrome NA BeFree Detail
0.002 Nerve Degeneration NA GAD Detail
0.007 obesity Cytokines of the IL-1 family are important modulators of obesity-induced inflamm... BeFree,GAD 25182023 Detail
0.007 obesity Furthermore, the administration of IL-1 receptor antagonist to obese mice marked... BeFree,GAD 25216251 Detail
0.002 Dermatitis, Occupational NA GAD Detail
0.002 Occupational Diseases NA GAD Detail
0.003 Odontogenic Tumors NA BeFree,LHGDN Detail
0.001 Osteitis NA BeFree Detail
<0.001 Osteitis Deformans NA BeFree Detail
0.028 Degenerative polyarthritis Using rabbit and human synovial fibroblast cell lines, we examined the effects o... BeFree,GAD 25496568 Detail
<0.001 Osteoarthritis of hip NA BeFree Detail
0.005 osteomyelitis NA BeFree,GAD Detail
0.004 osteoporosis NA BeFree,LHGDN Detail
0.008 Osteoporosis, Postmenopausal NA BeFree,GAD Detail
0.001 osteosarcoma NA BeFree Detail
0.082 otitis media NA GAD,RGD Detail
0.003 ovarian carcinoma NA BeFree Detail
<0.001 Ovarian Diseases NA BeFree Detail
<0.001 Pain The interleukin-1α gene C>T polymorphism rs1800587 is associated with increased ... BeFree 24300227 Detail
<0.001 Pain Our purpose was to investigate the influence of polymorphisms in IL1A/B/RN on cy... BeFree 24747159 Detail
0.002 Pain, Postoperative NA GAD Detail
0.006 Pancreatic Neoplasm NA BeFree,LHGDN Detail
0.002 pancreatitis NA GAD Detail
<0.001 papilloma NA BeFree Detail
0.014 Parkinson disease NA GAD Detail
0.003 Pemphigoid, Benign Mucous Membrane NA LHGDN Detail
0.007 pemphigus NA GAD Detail
0.002 pemphigus vulgaris NA GAD Detail
0.001 familial Mediterranean fever NA BeFree Detail
0.030 Periodontal Diseases NA BeFree,GAD Detail
0.014 Periodontal Pocket NA BeFree,GAD Detail
0.106 periodontitis A meta-analysis of the three populations supported the association between the I... BeFree,GAD,LHGDN 24690098 Detail
0.015 Periodontitis, Juvenile NA BeFree,GAD,LHGDN Detail
<0.001 Polymorphous light eruption NA BeFree Detail
<0.001 pituitary adenoma NA BeFree Detail
0.002 Pituitary Diseases NA BeFree Detail
<0.001 plasmacytoma NA BeFree Detail
0.002 Pleural effusion disorder NA GAD Detail
<0.001 pleuropneumonia NA BeFree Detail
<0.001 Pneumococcal Infections NA BeFree Detail
0.005 pneumoconiosis NA GAD Detail
0.083 pneumonia NA BeFree,GAD,RGD Detail
0.080 aspiration pneumonia NA RGD Detail
0.009 polycystic ovary syndrome The studies involved the following polymorphisms: TNF-α -308G > A, TNF-α -805C>T... BeFree,GAD,LHGDN 25690158 Detail
<0.001 polymyalgia rheumatica NA BeFree Detail
0.002 Postoperative Complications NA GAD Detail
0.007 pre-eclampsia NA GAD Detail
0.002 Pregnancy Complications, Hematologic NA GAD Detail
<0.001 ectopic pregnancy NA BeFree Detail
<0.001 Pseudorabies NA BeFree Detail
0.006 psoriasis NA BeFree,GAD Detail
0.002 Puerperal Disorders NA GAD Detail
0.090 pulmonary fibrosis NA BeFree,GAD,RGD Detail
<0.001 Raynaud disease NA BeFree Detail
0.002 reflex sympathetic dystrophy NA GAD Detail
0.002 kidney failure NA BeFree Detail
0.200 Reperfusion Injury NA CTD_human,RGD Detail
0.003 Respiratory Distress Syndrome, Newborn NA BeFree,GAD Detail
0.002 Respiratory Distress Syndrome, Adult NA BeFree Detail
0.002 Respiratory Hypersensitivity NA GAD Detail
0.002 Respiratory Syncytial Virus Infections NA GAD Detail
0.002 retinopathy of prematurity NA GAD Detail
<0.001 Rheumatism NA BeFree Detail
<0.001 Rheumatoid Nodule NA BeFree Detail
0.005 rhinitis NA GAD Detail
0.009 sarcoidosis NA BeFree,GAD Detail
0.003 Sarcoidosis, Pulmonary NA BeFree,GAD Detail
<0.001 Kaposi sarcoma NA BeFree Detail
0.008 schizophrenia Moreover, recent studies suggested that IL-1 participates in the progression of ... BeFree,GAD 25858413 Detail
0.032 systemic scleroderma NA BeFree,GAD,LHGDN Detail
<0.001 Seizures NA BeFree Detail
0.001 Septicemia NA BeFree Detail
0.080 Shock, Hemorrhagic NA RGD Detail
<0.001 Shoulder Pain NA BeFree Detail
<0.001 Shy-Drager Syndrome NA BeFree Detail
0.010 silicosis NA BeFree,GAD,LHGDN Detail
0.003 sinusitis NA BeFree,GAD Detail
0.124 Dermatologic disorders IL-33 is a novel IL-1 family member with a putative role in inflammatory skin di... BeFree,CTD_human,GAD 25739051 Detail
<0.001 Skin lesion As Th17 cytokines, such as IL-17A, and IL-1 family members, such as IL-36, play ... BeFree 25299544 Detail
0.120 Skin Neoplasms NA CTD_human Detail
0.002 Skin Ulcer NA GAD Detail
<0.001 smallpox NA BeFree Detail
0.005 Spinal Diseases NA GAD Detail
0.015 ankylosing spondylitis NA BeFree,GAD Detail
<0.001 Stomach Diseases NA BeFree Detail
0.015 Stomach Neoplasms NA BeFree,GAD,LHGDN Detail
<0.001 gastric ulcer NA BeFree Detail
0.003 stomatitis NA LHGDN Detail
0.007 aphthous stomatitis NA GAD Detail
0.002 Streptococcal Infections NA GAD Detail
<0.001 Stress, Psychological NA BeFree Detail
0.008 Cerebrovascular accident The association between three promoter polymorphisms of IL-1 and stroke: a meta-... BeFree,GAD 25917615 Detail
0.005 Subarachnoid Hemorrhage NA BeFree,GAD Detail
0.003 sudden infant death syndrome NA BeFree,GAD Detail
<0.001 synovitis NA BeFree Detail
<0.001 Giant Cell Arteritis NA BeFree Detail
<0.001 Testicular Neoplasms NA BeFree Detail
<0.001 thromboangiitis obliterans NA BeFree Detail
<0.001 thymoma NA BeFree Detail
0.002 Thyroid Diseases NA GAD Detail
0.003 trachoma NA BeFree,GAD Detail
<0.001 Chagas disease NA BeFree Detail
0.009 tuberculosis Most of the host components involved in TB inflammation, including cytokines (in... BeFree,GAD 25453228 Detail
0.003 Tuberculosis, Pulmonary Peripheral blood mononuclear cells from 42 healthy controls (HCs) and 42 pulmona... BeFree,GAD 25194676 Detail
0.003 Tuberculosis, Pulmonary In this study we aimed to examine the possible association between the variable ... BeFree,GAD 25530139 Detail
<0.001 typhoid fever NA BeFree Detail
<0.001 Unipolar Depression NA BeFree Detail
0.003 Erythema NA BeFree,GAD Detail
0.080 urinary tract infection NA BeFree,RGD Detail
<0.001 urticaria NA BeFree Detail
0.081 uveitis New cytokine inhibitors targeting IL-1 and IL-6 appear to be effective especiall... BeFree,RGD 26487500 Detail
0.080 varicocele NA RGD Detail
<0.001 Vascular Diseases NA BeFree Detail
<0.001 vasculitis NA BeFree Detail
0.080 Venous Thrombosis NA RGD Detail
0.002 Viremia NA GAD Detail
<0.001 Virus Diseases NA BeFree Detail
<0.001 Congenital Nonbullous Ichthyosiform Erythroderma NA BeFree Detail
0.002 Helicobacter Infections NA GAD Detail
0.002 B-Cell Lymphomas NA GAD Detail
0.003 diffuse large B-cell lymphoma NA BeFree,GAD Detail
0.003 T-Cell Lymphoma NA BeFree,GAD Detail
0.006 Tooth Loss NA BeFree,GAD Detail
<0.001 severe combined immunodeficiency NA BeFree Detail
0.002 Bronchial Hyperreactivity NA GAD Detail
<0.001 bacterial vaginosis The levels of interleukin-1α (IL-1α), IL-1β, IL-6, IL-12(p70), and IL-8 were ele... BeFree 25761460 Detail
<0.001 Neurofibrillary degeneration (morphologic abnormality) NA BeFree Detail
<0.001 Restrictive lung disease NA BeFree Detail
<0.001 pyoderma gangrenosum IL-1 may be involved in clinical manifestation of certain (genetic) forms of PG. BeFree 24898196 Detail
0.121 polymyositis NA BeFree,CTD_human Detail
<0.001 acute leukemia The aim of this study was to investigate the mannose-binding lectin 2 (MBL-2), i... BeFree 24819208 Detail
<0.001 Chronic gastritis NA BeFree Detail
<0.001 Hypokinesia NA BeFree Detail
<0.001 Chronic sinusitis NA BeFree Detail
<0.001 Pancreatitis, Chronic NA BeFree Detail
0.003 Epstein-Barr Virus Infections NA BeFree,GAD Detail
0.005 Migraine Disorders NA BeFree,GAD Detail
0.019 Premature Birth NA GAD,LHGDN Detail
0.120 Myocardial Ischemia NA BeFree,CTD_human Detail
<0.001 Adenocarcinoma of lung (disorder) NA BeFree Detail
<0.001 Pustular psoriasis NA BeFree Detail
<0.001 Malignant neoplasm of oropharynx A functional variant at miRNA-122 binding site in IL-1α 3' UTR predicts risk and... BeFree 25981582 Detail
<0.001 Secondary malignant neoplasm of lung NA BeFree Detail
<0.001 Corneal pannus NA BeFree Detail
<0.001 Middle Ear Cholesteatoma NA BeFree Detail
<0.001 Peritoneal adhesion NA BeFree Detail
0.004 Intervertebral Disc Degeneration NA BeFree,GAD Detail
<0.001 adrenoleukodystrophy NA BeFree Detail
<0.001 iron deficiency anemia NA BeFree Detail
<0.001 Polyarthritis NA BeFree Detail
<0.001 Prion Diseases NA BeFree Detail
0.120 Mitochondrial Myopathies NA CTD_human Detail
0.120 MELAS syndrome NA CTD_human Detail
0.120 MERRF syndrome NA CTD_human Detail
0.120 chronic progressive external ophthalmoplegia NA CTD_human Detail
0.120 Dermatitis, Allergic Contact NA CTD_human Detail
0.005 Dermatitis, Irritant NA BeFree,GAD Detail
<0.001 hidradenitis suppurativa In patients with a pyoderma gangrenosum, acne, and suppurative hidradenitis synd... BeFree 24898196 Detail
0.002 Aortic Aneurysm, Abdominal NA GAD Detail
0.001 Tumor Progression Mounting evidence supports that chronic inflammation (such as chronic overactiva... BeFree 25054228 Detail
0.001 Tumor Progression Reciprocal interaction between carcinoma-associated fibroblasts and squamous car... BeFree 25425967 Detail
<0.001 Diabetes, Autoimmune NA BeFree Detail
0.083 Lung Diseases, Interstitial NA BeFree,GAD,RGD Detail
0.019 Periodontal Attachment Loss NA BeFree,GAD Detail
0.003 Lichen Planus, Oral NA BeFree,GAD Detail
0.120 Chondrosarcoma, Mesenchymal NA CTD_human Detail
<0.001 Follicular thyroid carcinoma NA BeFree Detail
<0.001 Reactive systemic amyloidosis NA BeFree Detail
<0.001 Adult type dermatomyositis NA BeFree Detail
0.005 Lytic lesion NA GAD Detail
<0.001 Effects of heat NA BeFree Detail
<0.001 Premature aging syndrome NA BeFree Detail
<0.001 Memory impairment NA BeFree Detail
0.001 pancreatic carcinoma NA BeFree Detail
<0.001 Renal interstitial fibrosis NA BeFree Detail
<0.001 Hereditary pancreatitis NA BeFree Detail
<0.001 Papillary thyroid carcinoma NA BeFree Detail
<0.001 Iron deficiency NA BeFree Detail
<0.001 Hepatitis, Autoimmune NA BeFree Detail
0.005 coronary stenosis NA GAD Detail
0.013 Malignant neoplasm of lung NA BeFree,GAD Detail
0.002 age related macular degeneration NA GAD Detail
<0.001 nephropathia epidemica NA BeFree Detail
0.013 Sepsis NA BeFree,GAD Detail
<0.001 Psoriasiform eczema NA BeFree Detail
<0.001 Epithelial hyperplasia of skin NA BeFree Detail
<0.001 Dermatomyositis, Childhood Type NA BeFree Detail
<0.001 Chronic arthritis NA BeFree Detail
<0.001 Osteoarthritis of the hand NA BeFree Detail
<0.001 Degeneration of lumbar intervertebral disc NA BeFree Detail
0.023 Chronic Periodontitis This study validated the influence of IL-1 genetic factors on the severity of ch... BeFree,GAD,LHGDN 24690098 Detail
0.023 Chronic Periodontitis The objectives of this study were to determine the association between single nu... BeFree,GAD,LHGDN 25710474 Detail
<0.001 Muckle-Wells syndrome NA BeFree Detail
<0.001 Spastic syndrome NA BeFree Detail
<0.001 Acquired aplastic anemia NA BeFree Detail
<0.001 Coinfection NA BeFree Detail
<0.001 Tuberculosis of intestines NA BeFree Detail
<0.001 Familial Alzheimer Disease (FAD) NA BeFree Detail
<0.001 Invasive Pulmonary Aspergillosis NA BeFree Detail
<0.001 Radicular pain The interleukin-1α gene C>T polymorphism rs1800587 is associated with increased ... BeFree 24300227 Detail
<0.001 Metastatic melanoma NA BeFree Detail
<0.001 Solid tumour NA BeFree Detail
<0.001 stage, gastric cancer NA BeFree Detail
0.001 Adenocarcinoma of pancreas NA BeFree Detail
0.002 cervix carcinoma Association of an insertion/deletion polymorphism in IL1A 3'-UTR with risk for c... BeFree 24862933 Detail
<0.001 Obesity, Abdominal NA BeFree Detail
0.120 Arsenic Poisoning NA CTD_human Detail
<0.001 Dryness of eye NA BeFree Detail
0.003 Restenosis NA BeFree,GAD Detail
<0.001 Superficial ulcer NA BeFree Detail
0.001 Senile Plaques NA BeFree Detail
0.001 Tumor necrosis NA BeFree Detail
<0.001 Adenocarcinoma of colon NA BeFree Detail
<0.001 Impaired cognition NA BeFree Detail
0.006 Thyroid associated opthalmopathies NA BeFree,GAD Detail
<0.001 Glaucoma, Primary Open Angle NA BeFree Detail
<0.001 Congenital neutropenia NA BeFree Detail
0.002 Complications of Diabetes Mellitus NA GAD Detail
0.002 Familial cold urticaria NA BeFree Detail
0.120 HIV Wasting Syndrome NA CTD_human Detail
<0.001 Malignant neoplasm of liver NA BeFree Detail
<0.001 Malignant neoplasm of pancreas NA BeFree Detail
<0.001 Cervical intraepithelial neoplasia grade 2 NA BeFree Detail
0.003 Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site NA BeFree Detail
<0.001 Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site NA BeFree Detail
0.003 Malignant neoplasm of vulva NA BeFree,GAD Detail
0.006 Malignant neoplasm of prostate Genetic polymorphism of interleukin-1A (IL-1A), IL-1B, and IL-1 receptor antagon... BeFree,GAD 25374200 Detail
0.005 Hematologic Neoplasms NA GAD Detail
0.080 Endotoxemia NA RGD Detail
0.005 Atopy NA GAD Detail
0.005 multiple system atrophy NA BeFree,GAD Detail
<0.001 Dysequilibrium syndrome NA BeFree Detail
<0.001 Primary immune deficiency disorder NA BeFree Detail
0.001 Early onset periodontitis NA BeFree Detail
0.120 Non-alcoholic Fatty Liver Disease NA CTD_human Detail
<0.001 Idiopathic crescentic glomerulonephritis NA BeFree Detail
<0.001 Chronic Kidney Insufficiency NA BeFree Detail
<0.001 Chronic small plaque psoriasis As Th17 cytokines, such as IL-17A, and IL-1 family members, such as IL-36, play ... BeFree 25299544 Detail
0.002 Chronic Infantile Neurological, Cutaneous, and Articular Syndrome However, epiphyseal overgrowth in NOMID is resistant to anti-IL-1 therapy and ma... BeFree 25302486 Detail
<0.001 Idiopathic osteoarthritis NA BeFree Detail
<0.001 Osteoarthritis of distal interphalangeal joint NA BeFree Detail
0.091 Osteoarthritis, Knee NA BeFree,GAD,LHGDN,RGD Detail
0.003 lupus erythematosus NA BeFree,GAD Detail
<0.001 Arthritis by pattern of joint involvement NA BeFree Detail
<0.001 Ichthyosis bullosa of Siemens NA BeFree Detail
<0.001 pricking of skin NA BeFree Detail
<0.001 Respiratory distress NA BeFree Detail
0.005 dementia NA BeFree,GAD Detail
<0.001 Necrotizing Enterocolitis NA BeFree Detail
<0.001 Sleep Apnea, Obstructive NA BeFree Detail
0.003 Metabolic syndrome X NA BeFree,GAD Detail
<0.001 Neurodegenerative Disorders NA BeFree Detail
0.008 Hepatitis C, Chronic NA BeFree,GAD,LHGDN Detail
<0.001 Schnitzler syndrome NA BeFree Detail
0.002 Mood Disorders NA GAD Detail
<0.001 X-Linked Lymphoproliferative Disorder NA BeFree Detail
<0.001 Thyroid carcinoma NA BeFree Detail
<0.001 Malignant glioma In this study, we examined whether human astrocytic cells (including malignant g... BeFree 25054228 Detail
<0.001 primary sclerosing cholangitis NA BeFree Detail
0.001 Osteosarcoma of bone NA BeFree Detail
<0.001 Chemical Carcinogenesis NA BeFree Detail
<0.001 Leukemogenesis NA BeFree Detail
0.002 prostate carcinoma Genetic polymorphism of interleukin-1A (IL-1A), IL-1B, and IL-1 receptor antagon... BeFree 25374200 Detail
0.002 Lung Diseases, Obstructive NA GAD Detail
<0.001 CARCINOMA OF VULVA NA BeFree Detail
<0.001 Hashimoto Disease NA BeFree Detail
0.001 Epithelial ovarian cancer A polymorphism at miRNA-122-binding site in the IL-1α 3'UTR is associated with r... BeFree 25195148 Detail
0.004 breast carcinoma NA BeFree Detail
<0.001 inflammatory joint disease NA BeFree Detail
0.001 Carcinoma of lung NA BeFree Detail
<0.001 CNS metastases New cytokine inhibitors targeting IL-1 and IL-6 appear to be effective especiall... BeFree 26487500 Detail
<0.001 colon carcinoma NA BeFree Detail
0.009 stomach carcinoma Inflammation, especially the cytokine response of the IL-1 family, has been show... BeFree 24557417 Detail
0.009 stomach carcinoma Moreover, the in vitro production of proangiogenic factors in response to FPR2/3... BeFree 25263443 Detail
0.001 Carcinoma of bladder NA BeFree Detail
<0.001 Anxiety state Variations in three cytokine genes (i.e., interleukin (IL) 1 beta, IL1 receptor ... BeFree 25249351 Detail
<0.001 acne NA BeFree Detail
<0.001 Subfertility NA BeFree Detail
<0.001 Febrile Neutropenia The aim of this study was to investigate the mannose-binding lectin 2 (MBL-2), i... BeFree 24819208 Detail
<0.001 Idiopathic Inflammatory Myopathies NA BeFree Detail
0.001 Marden-Walker syndrome NA BeFree Detail
<0.001 Spots on skin NA BeFree Detail
0.009 Helicobacter pylori infection The data from the current study showed that the genotype IL-1B -511T/-31C-IL1-RN... BeFree,GAD 25292060 Detail
<0.001 Cognitive deterioration NA BeFree Detail
<0.001 Acute GVH disease NA BeFree Detail
0.120 Drug-Induced Liver Injury NA CTD_human Detail
0.003 Chronic graft-versus-host disease NA BeFree,GAD Detail
<0.001 Hyperkeratosis NA BeFree Detail
<0.001 Infectious disease of lung NA BeFree Detail
0.121 Cardiomyopathies NA BeFree,CTD_human Detail
0.120 Optic Atrophy, Hereditary, Leber NA CTD_human Detail
<0.001 Cerebral Ischemia NA BeFree Detail
<0.001 Arteriovenous Malformations, Cerebral NA BeFree Detail
0.003 ovarian neoplasm NA BeFree,LHGDN Detail
<0.001 autoimmune thyroiditis NA BeFree Detail
<0.001 Renal ischaemia NA BeFree Detail
<0.001 precancerous lesions NA BeFree Detail
<0.001 Vascular inflammations NA BeFree Detail
0.004 Ischemic stroke NA BeFree,GAD Detail
0.003 Acute coronary syndrome NA BeFree,GAD Detail
<0.001 Ovarian adenocarcinoma NA BeFree Detail
<0.001 Convulsion in childhood NA BeFree Detail
0.002 coronary restenosis NA GAD Detail
<0.001 Tauopathies NA BeFree Detail
<0.001 Spondylarthritis NA BeFree Detail
0.003 Spondylarthropathies NA BeFree,GAD Detail
<0.001 Arthritis, Collagen-Induced NA BeFree Detail
0.080 Arthritis, Experimental NA RGD Detail
<0.001 West Nile viral infection NA BeFree Detail
<0.001 Breakthrough Pain Our purpose was to investigate the influence of polymorphisms in IL1A/B/RN on cy... BeFree 24747159 Detail
<0.001 Monoclonal Gammapathies NA BeFree Detail
<0.001 Mental Retardation, X-Linked NA BeFree Detail
0.007 Malignant neoplasm of ovary NA BeFree,GAD Detail
<0.001 Squamous cell carcinoma of the head and neck Human HNSCC tumors showed higher IL1α mRNA levels compared with matched normal t... BeFree 25712126 Detail
0.002 severe acute respiratory syndrome NA GAD Detail
<0.001 sarcoma NA BeFree Detail
<0.001 major depressive disorder NA BeFree Detail
<0.001 Left ventricular systolic dysfunction NA BeFree Detail
<0.001 Anxiety neurosis (finding) Variations in three cytokine genes (i.e., interleukin (IL) 1 beta, IL1 receptor ... BeFree 25249351 Detail
<0.001 Degenerative disorder NA BeFree Detail
0.002 Inflammatory disorder Interleukin-33 (IL-33), a new member of the IL-1 family, plays an important role... BeFree 25846650 Detail
0.002 Inflammatory disorder Interleukin-33 (IL-33) is a member of the IL-1 cytokine superfamily that potentl... BeFree 26107423 Detail
<0.001 Abdominal bloating Levels of IL-1α and β were higher among patients with SIBO than without (IL-1α: ... BeFree 25073651 Detail
<0.001 Precursor B-cell lymphoblastic leukemia NA BeFree Detail
0.002 Death (finding) NA GAD Detail
<0.001 M5b Acute differentiated monocytic leukemia NA BeFree Detail
<0.001 Hepatitis B Virus-Related Hepatocellular Carcinoma NA BeFree Detail
<0.001 High Grade Cervical Intraepithelial Neoplasia NA BeFree Detail
<0.001 Mucinous Neoplasm Expression of IL-1, TNF-α and COX-2 increased with the stage of the disease in b... BeFree 25007180 Detail
<0.001 pancreatic ductal adenocarcinoma NA BeFree Detail
<0.001 Congenital absence of germinal epithelium of testes NA BeFree Detail
<0.001 Generalized osteoarthritis NA BeFree Detail
<0.001 Systemic onset juvenile chronic arthritis Additionally, DNA microarray technology led to our discovery that the interleuki... BeFree 24839407 Detail
0.003 Mammary Neoplasms NA BeFree,LHGDN Detail
<0.001 Hepatocarcinogenesis NA BeFree Detail
<0.001 Cervical high grade squamous intraepithelial lesion NA BeFree Detail
<0.001 Skin Carcinogenesis NA BeFree Detail
<0.001 Tumor Angiogenesis NA BeFree Detail
<0.001 Xenograft Model NA BeFree Detail
0.006 colorectal cancer NA BeFree,GAD Detail
<0.001 fertility disorders NA BeFree Detail
<0.001 Non-Malignant Ascites Adverse Event NA BeFree Detail
<0.001 Chronic Kidney Diseases NA BeFree Detail
<0.001 Renal Insufficiency NA BeFree Detail
<0.001 Aggressive periodontitis, generalized Genetic polymorphisms of TNFA and IL-1A and generalized aggressive periodontitis... BeFree 26193214 Detail
0.004 Idiopathic Pulmonary Fibrosis NA BeFree,LHGDN Detail
<0.001 NEPHROLITHIASIS, CALCIUM OXALATE NA BeFree Detail
<0.001 IMMUNE SUPPRESSION NA BeFree Detail
<0.001 Recurrent bacterial infection NA BeFree Detail
<0.001 Nakajo syndrome NA BeFree Detail
<0.001 severe congenital neutropenia NA BeFree Detail
0.005 Venous thromboembolism NA GAD Detail
<0.001 SYNOVITIS, GRANULOMATOUS, WITH UVEITIS AND CRANIAL NEUROPATHIES (disorder) NA BeFree Detail
<0.001 Majeed syndrome NA BeFree Detail
<0.001 Severe Aplastic Anemia NA BeFree Detail
0.007 coronary artery disease NA BeFree,GAD Detail
0.008 liver carcinoma NA BeFree,GAD Detail
0.005 Cryopyrin-Associated Periodic Syndromes The use of IL-1-antagonists has been associated with beneficial effects in a lar... BeFree 25149390 Detail
0.005 Cryopyrin-Associated Periodic Syndromes Unexpectedly, IL-1α secretion is increased 10-fold, indicating that inflammatory... BeFree 25730877 Detail
<0.001 Chronic kidney disease stage 5 NA BeFree Detail
<0.001 Destructive Arthritis NA BeFree Detail
<0.001 Oropharyngeal Carcinoma A functional variant at miRNA-122 binding site in IL-1α 3' UTR predicts risk and... BeFree 25981582 Detail
<0.001 Pulmonary Aspergillosis A prominent role for the IL1 pathway and IL15 in susceptibility to chronic cavit... BeFree 24274595 Detail
<0.001 Bronchopulmonary Aspergillosis A prominent role for the IL1 pathway and IL15 in susceptibility to chronic cavit... BeFree 24274595 Detail
<0.001 Allergic rhinitis (disorder) NA BeFree Detail
<0.001 Merkel Cell Polyomavirus Infection MCPyV infection can trigger precursor LCH cells with BRAF mutation to produce IL... BeFree 25889448 Detail
<0.001 Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis NA BeFree Detail
0.002 Infection of amniotic sac and membranes, unspecified, unspecified trimester, not applicable or unspecified NA GAD Detail
0.002 Chronic ulcerative colitis NA GAD Detail
<0.001 Juvenile dermatomyositis NA BeFree Detail
0.001 Nasopharyngeal carcinoma NA BeFree Detail
0.002 Peri-Implantitis NA BeFree Detail
<0.001 Plaque, Amyloid NA BeFree Detail
<0.001 Stroke, Lacunar NA BeFree Detail
<0.001 Nonalcoholic Steatohepatitis NA BeFree Detail
0.004 Ischemic Cerebrovascular Accident NA BeFree,GAD Detail
<0.001 Severe dementia NA BeFree Detail
0.012 Juvenile arthritis NA BeFree,GAD Detail
<0.001 AA amyloidosis NA BeFree Detail
<0.001 Allergic disposition NA BeFree Detail
<0.001 Drug Hypersensitivity Syndrome NA BeFree Detail
0.001 Neutrophilia (disorder) NA BeFree Detail
0.005 Infection NA GAD Detail
<0.001 Pneumonitis NA BeFree Detail
<0.001 intellectual disability Involvement of IL-6 and IL-1 receptor antagonist on intellectual disability. BeFree 25124963 Detail
0.003 juvenile rheumatoid arthritis NA BeFree Detail
0.003 Acne Vulgaris NA BeFree,GAD Detail
0.003 acquired immunodeficiency syndrome NA BeFree,GAD Detail
0.001 acute pancreatitis NA BeFree Detail
0.003 adenocarcinoma NA BeFree,GAD Detail
<0.001 Primary myelofibrosis NA BeFree Detail
0.002 AIDS Dementia Complex NA GAD Detail
0.005 Alcoholic Intoxication, Chronic NA BeFree,GAD Detail
0.004 alopecia areata NA BeFree,GAD Detail
0.024 Alveolar Bone Loss NA GAD Detail
0.079 Alzheimer's disease NA BeFree,GAD,LHGDN Detail
0.120 Amnesia NA CTD_human Detail
<0.001 amyloidosis NA BeFree Detail
<0.001 anemia NA BeFree Detail
0.002 Angina Pectoris NA GAD Detail
0.002 Angina, Unstable NA GAD Detail
0.003 Fabry disease NA BeFree,GAD Detail
<0.001 cutaneous fibrous histiocytoma NA BeFree Detail
0.080 Anorexia NA RGD Detail
0.123 anthracosis NA BeFree,CTD_human,GAD Detail
<0.001 aortic aneurysm NA BeFree Detail
0.006 arteriosclerosis These data also suggest that inhibition of this potentially important source of ... BeFree,GAD 26139463 Detail
0.026 arthritis NA BeFree,GAD,LHGDN Detail
0.006 Arthritis, Psoriatic NA BeFree,GAD Detail
0.046 rheumatoid arthritis Anakinra (IL-1 receptor antagonist) and tocilizumab (monoclonal IL-6 receptor an... BeFree,GAD,LHGDN 23635711 Detail
0.002 aspergillosis NA GAD Detail
0.021 asthma However, there was a significant relationship between the A/A genotype in the -1... BeFree,GAD 25223230 Detail
0.021 asthma IL-33 is a nuclear cytokine from the IL-1 family constitutively expressed in epi... BeFree,GAD 25278425 Detail
0.002 Astrocytoma NA BeFree Detail
0.011 atherosclerosis These data also suggest that inhibition of this potentially important source of ... BeFree,GAD 26139463 Detail
0.002 atrial fibrillation NA GAD Detail
0.006 Autoimmune Diseases IL-37, a new member of the IL-1 cytokine family, is a natural inhibitor of innat... BeFree,GAD 25917106 Detail
<0.001 Bacterial Infections NA BeFree Detail
<0.001 Balkan nephropathy NA BeFree Detail
0.010 Behcet Syndrome NA BeFree,GAD,LHGDN Detail
0.002 berylliosis NA GAD Detail
0.002 Biliary Tract Neoplasm NA GAD Detail
<0.001 bipolar disorder NA BeFree Detail
0.005 Malignant neoplasm of urinary bladder NA BeFree,GAD Detail
0.003 Bladder Neoplasm NA LHGDN Detail
<0.001 Blood Coagulation Disorders NA BeFree Detail
0.003 Bone Diseases NA BeFree,GAD Detail
0.002 Metabolic Bone Disorder NA GAD Detail
0.018 Malignant neoplasm of breast NA BeFree,GAD Detail
0.002 Bronchiolitis, Viral NA GAD Detail
<0.001 Cachexia NA BeFree Detail
<0.001 Malignant tumor of colon NA BeFree Detail
<0.001 Carcinoma, Papillary NA BeFree Detail
0.003 renal cell carcinoma Indeed, targeting of IL-1-IL-1R axis in a human RCC xenograft model abrogated th... BeFree,GAD 25453823 Detail
Annotation

Annotations

DescrptionSourceLinks
Reciprocal interaction between carcinoma-associated fibroblasts and squamous carcinoma cells through... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
As Th17 cytokines, such as IL-17A, and IL-1 family members, such as IL-36, play a significant role i... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
However, there was a significant relationship between the A/A genotype in the -152 G/A IL1-7A SNP an... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
These data provide the first in vivo evidence—using a transgenic mouse model with amyloid deposits r... DisGeNET Detail
Oxidative stress and its association with TNF-α-308 G/C and IL-1α-889 C/T gene polymorphisms in pati... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
Primary human corneal epithelial cells (HCEC), an SV40 HCEC cell line or a normal human conjunctival... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
However, there was a significant relationship between the A/A genotype in the -152 G/A IL1-7A SNP an... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
The data from the current study showed that the genotype IL-1B -511T/-31C-IL1-RN-2 and H. pylori inf... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
Specifically, the ability to produce IL-1 by glioblastoma cells may confer them a mesenchymal phenot... DisGeNET Detail
IL-1 also activated Stat3, a transcription factor crucial in glioma progression. DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
MCPyV infection can trigger precursor LCH cells with BRAF mutation to produce IL-1; the IL-1 loop is... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
IL-1 SNPs seem to be associated with IBD and could affect the disease severity as well. DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
Polymorphisms of IL-RA gene (anti-inflammatory) was evaluated in IBS and healthy subjects (HS); smal... DisGeNET Detail
Our data suggest that central inhibition of IL-1α or Tox3 overexpression during the acute phase of a... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
Moreover, recent studies suggested that IL-1 participates in the progression of lung disease in smok... DisGeNET Detail
NA DisGeNET Detail
The interleukin-1 (IL-1) gene polymorphisms have been implicated in chronic obstructive pulmonary di... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
Meta-analysis of associations of IL1 receptor antagonist and estrogen receptor gene polymorphisms wi... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
Inflammation, especially the cytokine response of the IL-1 family, has been shown to influence susce... DisGeNET Detail
Moreover, the in vitro production of proangiogenic factors in response to FPR2/3 agonists (WKYMVm, L... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
To replicate and extend recent findings in a Turkish population of associations between chronic rhin... DisGeNET Detail
NA DisGeNET Detail
To replicate and extend recent findings in a Turkish population of associations between chronic rhin... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
These results suggest that tested SNPs associated with differential production of IL-1 female and IL... DisGeNET Detail
Assuming a dominant genetic model, IL1A A114S significantly modified the dose-response relationship ... DisGeNET Detail
Assuming a dominant genetic model, IL1A A114S significantly modified the dose-response relationship ... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
Our results of the association of IL-1α gene single nucleotide polymorphisms (SNPs) rs2071375 (+1253... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
Cytokines of the IL-1 family are important modulators of obesity-induced inflammation and the develo... DisGeNET Detail
Furthermore, the administration of IL-1 receptor antagonist to obese mice markedly reduced obesity-i... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
Using rabbit and human synovial fibroblast cell lines, we examined the effects of Cx43 overexpressio... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
The interleukin-1α gene C>T polymorphism rs1800587 is associated with increased pain intensity and d... DisGeNET Detail
Our purpose was to investigate the influence of polymorphisms in IL1A/B/RN on cytokine serum levels ... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
A meta-analysis of the three populations supported the association between the IL-1 genotype pattern... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
The studies involved the following polymorphisms: TNF-α -308G > A, TNF-α -805C>T, TNF-α -1031 T>C, I... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
Moreover, recent studies suggested that IL-1 participates in the progression of lung disease in smok... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
IL-33 is a novel IL-1 family member with a putative role in inflammatory skin disorders and a comple... DisGeNET Detail
As Th17 cytokines, such as IL-17A, and IL-1 family members, such as IL-36, play a significant role i... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
The association between three promoter polymorphisms of IL-1 and stroke: a meta-analysis. DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
Most of the host components involved in TB inflammation, including cytokines (interferons, interleuk... DisGeNET Detail
Peripheral blood mononuclear cells from 42 healthy controls (HCs) and 42 pulmonary tuberculosis (PTB... DisGeNET Detail
In this study we aimed to examine the possible association between the variable number of tandem rep... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
New cytokine inhibitors targeting IL-1 and IL-6 appear to be effective especially for uveitis and CN... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
The levels of interleukin-1α (IL-1α), IL-1β, IL-6, IL-12(p70), and IL-8 were elevated, whereas the I... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
IL-1 may be involved in clinical manifestation of certain (genetic) forms of PG. DisGeNET Detail
NA DisGeNET Detail
The aim of this study was to investigate the mannose-binding lectin 2 (MBL-2), interleukin (IL)-4, T... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
A functional variant at miRNA-122 binding site in IL-1α 3' UTR predicts risk and HPV-positive tumour... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
In patients with a pyoderma gangrenosum, acne, and suppurative hidradenitis syndrome these mutations... DisGeNET Detail
NA DisGeNET Detail
Mounting evidence supports that chronic inflammation (such as chronic overactivation of IL-1 system)... DisGeNET Detail
Reciprocal interaction between carcinoma-associated fibroblasts and squamous carcinoma cells through... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
This study validated the influence of IL-1 genetic factors on the severity of chronic periodontitis ... DisGeNET Detail
The objectives of this study were to determine the association between single nucleotide polymorphis... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
The interleukin-1α gene C>T polymorphism rs1800587 is associated with increased pain intensity and d... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
Association of an insertion/deletion polymorphism in IL1A 3'-UTR with risk for cervical carcinoma in... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
Genetic polymorphism of interleukin-1A (IL-1A), IL-1B, and IL-1 receptor antagonist (IL-1RN) and pro... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
As Th17 cytokines, such as IL-17A, and IL-1 family members, such as IL-36, play a significant role i... DisGeNET Detail
However, epiphyseal overgrowth in NOMID is resistant to anti-IL-1 therapy and may therefore occur in... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
In this study, we examined whether human astrocytic cells (including malignant gliomas) can produce ... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
Genetic polymorphism of interleukin-1A (IL-1A), IL-1B, and IL-1 receptor antagonist (IL-1RN) and pro... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
A polymorphism at miRNA-122-binding site in the IL-1α 3'UTR is associated with risk of epithelial ov... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
New cytokine inhibitors targeting IL-1 and IL-6 appear to be effective especially for uveitis and CN... DisGeNET Detail
NA DisGeNET Detail
Inflammation, especially the cytokine response of the IL-1 family, has been shown to influence susce... DisGeNET Detail
Moreover, the in vitro production of proangiogenic factors in response to FPR2/3 agonists (WKYMVm, L... DisGeNET Detail
NA DisGeNET Detail
Variations in three cytokine genes (i.e., interleukin (IL) 1 beta, IL1 receptor 2 (IL1R2), nuclear f... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
The aim of this study was to investigate the mannose-binding lectin 2 (MBL-2), interleukin (IL)-4, T... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
The data from the current study showed that the genotype IL-1B -511T/-31C-IL1-RN-2 and H. pylori inf... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
Our purpose was to investigate the influence of polymorphisms in IL1A/B/RN on cytokine serum levels ... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
Human HNSCC tumors showed higher IL1α mRNA levels compared with matched normal tissue, and IL1α was ... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
Variations in three cytokine genes (i.e., interleukin (IL) 1 beta, IL1 receptor 2 (IL1R2), nuclear f... DisGeNET Detail
NA DisGeNET Detail
Interleukin-33 (IL-33), a new member of the IL-1 family, plays an important role in both inflammator... DisGeNET Detail
Interleukin-33 (IL-33) is a member of the IL-1 cytokine superfamily that potently drives production ... DisGeNET Detail
Levels of IL-1α and β were higher among patients with SIBO than without (IL-1α: 35.4 [20.1-66.8] vs ... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
Expression of IL-1, TNF-α and COX-2 increased with the stage of the disease in both serous and mucin... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
Additionally, DNA microarray technology led to our discovery that the interleukin (IL)-1 gene signat... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
Genetic polymorphisms of TNFA and IL-1A and generalized aggressive periodontitis. DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
The use of IL-1-antagonists has been associated with beneficial effects in a large number of HAID as... DisGeNET Detail
Unexpectedly, IL-1α secretion is increased 10-fold, indicating that inflammatory episodes in CAPS ma... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
A functional variant at miRNA-122 binding site in IL-1α 3' UTR predicts risk and HPV-positive tumour... DisGeNET Detail
A prominent role for the IL1 pathway and IL15 in susceptibility to chronic cavitary pulmonary asperg... DisGeNET Detail
A prominent role for the IL1 pathway and IL15 in susceptibility to chronic cavitary pulmonary asperg... DisGeNET Detail
NA DisGeNET Detail
MCPyV infection can trigger precursor LCH cells with BRAF mutation to produce IL-1; the IL-1 loop is... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
Involvement of IL-6 and IL-1 receptor antagonist on intellectual disability. DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
These data also suggest that inhibition of this potentially important source of chronic inflammation... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
Anakinra (IL-1 receptor antagonist) and tocilizumab (monoclonal IL-6 receptor antibody) are two know... DisGeNET Detail
NA DisGeNET Detail
However, there was a significant relationship between the A/A genotype in the -152 G/A IL1-7A SNP an... DisGeNET Detail
IL-33 is a nuclear cytokine from the IL-1 family constitutively expressed in epithelial barrier tiss... DisGeNET Detail
NA DisGeNET Detail
These data also suggest that inhibition of this potentially important source of chronic inflammation... DisGeNET Detail
NA DisGeNET Detail
IL-37, a new member of the IL-1 cytokine family, is a natural inhibitor of innate immunity associate... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
Indeed, targeting of IL-1-IL-1R axis in a human RCC xenograft model abrogated the protumor phenotype... DisGeNET Detail

Overlapped Transcript Coordinates

Gene Transcript ID Exon Number Chromosome Start Stop Type Amino Mutation Transcript Position Links

Overlapped Transcript

Gene Transcript ID Chromosome Start Stop Links
Gene
-
dbSNP
rs17651 dbSNP
Genome
hg38
Position
chr2:112,773,925-112,784,493
Variant Type
snv
Genome browser