chr7:55086710:> Detail (hg19) (EGFR)

Information

Genome

Assembly Position
hg19 chr7:55,086,710-55,279,321
hg38 chr7:55,019,017-55,211,628 

HGVS

Type Transcript Protein
Summary

MGeND

Clinical significance
Variant entry
GWAS entry
Disease area statistics Show details

Frequency

[No Data.]

Prediction

[No Data.]

ClinVar

Clinical Significance
Review star [No Data.]
Show details
Links
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
[No Data.]
CIViC
Disease Drug EL ET ED CS VO TR Pubmed Links
lung non-small cell carcinoma Gefitinib C Predictive Supports Sensitivity/Response Somatic 4 24755888 Detail
lung adenocarcinoma Erlotinib B Predictive Supports Sensitivity/Response Somatic 4 22285168 Detail
lung non-small cell carcinoma Erlotinib C Predictive Supports Sensitivity/Response Somatic 21531810 Detail
lung non-small cell carcinoma Erlotinib,Gefitinib B Predictive Supports Sensitivity/Response Somatic 4 21531810 Detail
lung non-small cell carcinoma Erlotinib,Gefitinib B Predictive Supports Sensitivity/Response Somatic 4 21531810 Detail
lung non-small cell carcinoma Erlotinib,Gefitinib B Predictive Does Not Support Sensitivity/Response Somatic 2 21531810 Detail
lung adenocarcinoma Erlotinib C Predictive Supports Resistance Somatic 24353160 Detail
lung non-small cell carcinoma Erlotinib C Predictive Supports Resistance Somatic 24353160 Detail
lung adenocarcinoma Erlotinib C Predictive Supports Resistance Somatic 24353160 Detail
DisGeNET
Score Disease name Description Source Pubmed Links
0.277 squamous cell carcinoma Detection of mutation-specific epidermal growth factor receptor (E746-A750del) a... BeFree,CTD_human,GAD,LHGDN 24818747 Detail
0.277 squamous cell carcinoma Lack of mutations in protein tyrosine kinase domain coding exons 19 and 21 of th... BeFree,CTD_human,GAD,LHGDN 24969895 Detail
0.277 squamous cell carcinoma Over-expression of epidermal growth factor receptor (EGFR) has been identified a... BeFree,CTD_human,GAD,LHGDN 25081654 Detail
0.277 squamous cell carcinoma Our results suggest that EGFR expression in squamous cell carcinoma is different... BeFree,CTD_human,GAD,LHGDN 25279714 Detail
0.277 squamous cell carcinoma Acquired resistance to EGFR tyrosine kinase inhibitor in A431 squamous cell carc... BeFree,CTD_human,GAD,LHGDN 25510664 Detail
0.277 squamous cell carcinoma Our data show that the overall frequency of EGFR gene mutations in lung adenocar... BeFree,CTD_human,GAD,LHGDN 25534657 Detail
0.277 squamous cell carcinoma The occurrence of EGFR mutations in pulmonary SQCC might be overestimated. BeFree,CTD_human,GAD,LHGDN 25684486 Detail
0.277 squamous cell carcinoma Shikonin causes cell-cycle arrest and induces apoptosis by regulating the EGFR-N... BeFree,CTD_human,GAD,LHGDN 25720435 Detail
0.277 squamous cell carcinoma Epidermal growth factor receptor inhibition reduces angiogenesis via hypoxia-ind... BeFree,CTD_human,GAD,LHGDN 25723392 Detail
0.277 squamous cell carcinoma High-Frequency Targetable EGFR Mutations in Sinonasal Squamous Cell Carcinomas A... BeFree,CTD_human,GAD,LHGDN 25931286 Detail
0.277 squamous cell carcinoma This study details the empirical basis for a feasible clinical solution for squa... BeFree,CTD_human,GAD,LHGDN 26216950 Detail
0.004 Carcinoma, Transitional Cell NA BeFree Detail
<0.001 carcinosarcoma NA BeFree Detail
0.203 Cardiomyopathy, Dilated NA BeFree,CTD_human,GAD,RGD Detail
<0.001 celiac disease NA BeFree Detail
0.006 Malignant tumor of cervix Studies in cervical cancer indicate that E5 increases epidermal growth factor re... BeFree 25027574 Detail
0.006 Malignant tumor of cervix FTS is responsible for radiation-induced nuclear phosphorylation of EGFR and rep... BeFree 25151576 Detail
<0.001 Cervical dysplasia NA BeFree Detail
0.130 Uterine Cervical Neoplasm NA CTD_human,GAD,LHGDN Detail
<0.001 Developmental Disabilities NA BeFree Detail
<0.001 cholera NA BeFree Detail
<0.001 cholesteatoma NA BeFree Detail
<0.001 chondrosarcoma NA BeFree Detail
0.002 chordoma We find that miR-34a inversely correlates with MET expression and miR-608 invers... BeFree 24621885 Detail
0.001 choriocarcinoma NA BeFree Detail
0.005 Chromosome Aberrations NA GAD Detail
<0.001 Congenital chromosomal disease NA BeFree Detail
0.002 Chromosome Deletion NA GAD Detail
<0.001 colitis NA BeFree Detail
<0.001 ulcerative colitis NA BeFree Detail
0.140 Colonic Neoplasms NA BeFree,CTD_human,GAD,LHGDN Detail
0.170 Colorectal Neoplasms Three different macroscopic subtypes of colorectal neoplasms display distinct ca... BeFree,CTD_human,GAD,LHGDN 25551625 Detail
0.170 Colorectal Neoplasms We exploited circulating tumor DNA (ctDNA) to genotype colorectal tumors and tra... BeFree,CTD_human,GAD,LHGDN 26030179 Detail
<0.001 common cold We validated COLD-ddPCR on multiple mutations in TP53 and in EGFR using serial m... BeFree 25772705 Detail
<0.001 Coughing NA BeFree Detail
<0.001 craniopharyngioma NA BeFree Detail
<0.001 craniosynostosis NA BeFree Detail
0.001 adenoid cystic carcinoma NA BeFree Detail
0.004 Phyllodes Tumor Taken together, this study defines the genomic landscape underlying phyllodes tu... BeFree,LHGDN 25593300 Detail
0.003 Cytomegalovirus Infections NA LHGDN Detail
0.003 Cessation of life NA LHGDN Detail
<0.001 Demyelinating Diseases NA BeFree Detail
<0.001 Mental Depression NA BeFree Detail
<0.001 depressive disorder NA BeFree Detail
<0.001 dermatitis NA BeFree Detail
0.002 Drug Eruptions NA GAD Detail
<0.001 Dermatitis, Atopic Staphylococcus aureus skin colonization is universal in atopic dermatitis and co... BeFree 25902485 Detail
<0.001 dermoid cyst NA BeFree Detail
<0.001 Diabetes NA BeFree Detail
0.001 diabetes mellitus The 13 patients with DM were more likely to express IGF-1R (p=0.001) and had sho... BeFree 25617986 Detail
0.080 Diabetes Mellitus, Experimental NA RGD Detail
0.080 Diabetes Mellitus, Insulin-Dependent NA RGD Detail
0.120 Diabetes Mellitus, Non-Insulin-Dependent NA BeFree,CTD_human Detail
<0.001 Diabetic Nephropathy NA BeFree Detail
0.007 diarrhea In addition, EGFR wild type receptor inhibition inherent with these agents can l... BeFree,GAD 25271963 Detail
<0.001 diphtheria NA BeFree Detail
<0.001 Dry Eye Syndromes IL-6, IL-9, CCL24, CCL18, IL-10, IFN-γ, and CCL2 were highly increased (>6-fold)... BeFree 26200497 Detail
<0.001 Dupuytren Contracture NA BeFree Detail
<0.001 Dyspnea NA BeFree Detail
<0.001 Eczema Staphylococcus aureus skin colonization is universal in atopic dermatitis and co... BeFree 25902485 Detail
<0.001 subacute bacterial endocarditis Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have s... BeFree 25242669 Detail
<0.001 Endocrine Gland Neoplasms NA BeFree Detail
<0.001 Yolk Sac Tumor NA BeFree Detail
0.005 Endometrial Neoplasms NA GAD,LHGDN Detail
0.127 endometriosis NA BeFree,CTD_human,GAD,LHGDN Detail
0.004 Ependymoma NA BeFree,LHGDN Detail
<0.001 Epilepsy, Temporal Lobe NA BeFree Detail
<0.001 Erythroplasia NA BeFree Detail
0.140 Esophageal Neoplasms We show for the first time a significant treatment response to the EGFR tyrosine... BeFree,CTD_human,GAD,LHGDN 25070024 Detail
0.080 peptic esophagitis NA RGD Detail
0.011 Exanthema NA BeFree,GAD Detail
<0.001 Muscular fasciculation NA BeFree Detail
<0.001 Fatty Liver NA BeFree Detail
<0.001 breast fibrocystic disease NA BeFree Detail
0.003 Fibrosis NA LHGDN Detail
<0.001 pathologic fistula NA BeFree Detail
<0.001 Flatulence NA BeFree Detail
0.120 gallbladder neoplasm NA CTD_human Detail
<0.001 gastrinoma NA BeFree Detail
<0.001 gastritis NA BeFree Detail
<0.001 Gastritis, Atrophic NA BeFree Detail
<0.001 gastroesophageal reflux disease NA BeFree Detail
<0.001 Gastrointestinal Neoplasms NA BeFree Detail
0.003 Gliosis NA LHGDN Detail
<0.001 goiter NA BeFree Detail
<0.001 Graft-vs-Host Disease IL-6, IL-9, CCL24, CCL18, IL-10, IFN-γ, and CCL2 were highly increased (>6-fold)... BeFree 26200497 Detail
<0.001 granulosa cell tumor Epidermal growth factor receptor (EGFR), HER2 and insulin-like growth factor-1 r... BeFree 24206174 Detail
<0.001 Hamartoma NA BeFree Detail
0.003 Hay fever NA BeFree,LHGDN Detail
0.130 Head and Neck Neoplasms NA BeFree,CTD_human,GAD,LHGDN Detail
<0.001 Heart Diseases NA BeFree Detail
<0.001 Heart failure NA BeFree Detail
<0.001 congestive heart failure NA BeFree Detail
<0.001 Helminthiasis NA BeFree Detail
<0.001 Hematological Disease NA BeFree Detail
<0.001 hepatitis B NA BeFree Detail
0.006 hepatitis C Interferon-α inducible protein 6 impairs EGFR activation by CD81 and inhibits he... BeFree,GAD,LHGDN 25757571 Detail
0.006 hepatitis C Hepatitis C virus NS5A protein blocks epidermal growth factor receptor degradati... BeFree,GAD,LHGDN 25872741 Detail
0.006 hepatitis C Impact of epidermal growth factor receptor and transforming growth factor-α on h... BeFree,GAD,LHGDN 26279457 Detail
0.001 Herpes Simplex Infections To address the concern that this safety feature may reduce oncolytic activity, w... BeFree 25200130 Detail
0.001 HIV Infections A multi-institutional study of clinicopathological features and molecular epidem... BeFree 25800620 Detail
<0.001 Hydatidiform mole NA BeFree Detail
<0.001 Hydrothorax Diagnostic values of vascular endothelial growth factor and epidermal growth fac... BeFree 25635424 Detail
<0.001 hypercalcemia NA BeFree Detail
0.003 Hypercholesterolemia, Familial NA LHGDN Detail
<0.001 hyperparathyroidism NA BeFree Detail
0.002 Hyperparathyroidism, Secondary NA GAD Detail
0.102 Hyperplasia NA LHGDN,RGD Detail
0.002 Hypersensitivity NA GAD Detail
0.080 Hypertensive disease NA BeFree,RGD Detail
0.002 Hypopharyngeal Neoplasms NA GAD Detail
<0.001 Immunologic Deficiency Syndromes NA BeFree Detail
0.080 Inflammation NA RGD Detail
<0.001 Inflammatory Bowel Diseases NA BeFree Detail
<0.001 influenza NA BeFree Detail
0.120 Insulin resistance NA CTD_human Detail
<0.001 Intestinal Neoplasms NA BeFree Detail
<0.001 Intestinal Polyps NA BeFree Detail
<0.001 Keloid NA BeFree Detail
<0.001 actinic keratosis NA BeFree Detail
0.003 Kidney Diseases NA BeFree,LHGDN Detail
0.003 Kidney Neoplasm NA BeFree,GAD Detail
0.003 Polycystic Kidney Diseases NA BeFree,GAD Detail
0.006 Fibroid Tumor NA BeFree,LHGDN Detail
0.003 leukemia NA BeFree,LHGDN Detail
0.003 chronic lymphocytic leukemia NA BeFree,GAD Detail
0.001 Acute Erythroblastic Leukemia NA BeFree Detail
0.001 Leukemia, Myelocytic, Acute NA BeFree Detail
0.002 Myeloid Leukemia, Chronic A common germline deletion in the BIM gene was recently shown to favor the produ... BeFree 25090024 Detail
<0.001 acute promyelocytic leukemia NA BeFree Detail
<0.001 Leukoplakia NA BeFree Detail
<0.001 liver cirrhosis By immunohistochemistry EGFR and TGF-α were overexpressed in HCC and cirrhotic c... BeFree 26279457 Detail
<0.001 Liver diseases NA BeFree Detail
0.006 Liver neoplasms NA BeFree,GAD Detail
0.082 Lung diseases NA BeFree,RGD Detail
0.083 Chronic Obstructive Airway Disease NA BeFree,GAD,RGD Detail
<0.001 Lupus Vulgaris NA BeFree Detail
<0.001 Lupus Erythematosus, Discoid NA BeFree Detail
0.003 Lupus Erythematosus, Systemic NA BeFree,LHGDN Detail
0.013 Lymphatic Metastasis MiR-133a expression was negatively correlated to lymphatic metastasis (r = -0.18... BeFree,GAD 25903369 Detail
0.001 lymphoma The initial set of trials will focus on different questions: (1) Exceptional Res... BeFree 24857062 Detail
<0.001 Malabsorption Syndrome Consistent with previous studies demonstrating a role for muscarinic and epiderm... BeFree 26210740 Detail
0.030 Malignant neoplasm of stomach The present study was to determine the role of KRAS status in EGFR antibody trea... BeFree,GAD 24467518 Detail
0.030 Malignant neoplasm of stomach Many molecular pathways are currently under investigation as therapeutic targets... BeFree,GAD 24587678 Detail
0.030 Malignant neoplasm of stomach These results support the involvement of EGFR and HER2 in gastric cancer and sug... BeFree,GAD 24728052 Detail
0.030 Malignant neoplasm of stomach Inhibition of epidermal growth factor receptor signaling prohibits metastasis of... BeFree,GAD 25085584 Detail
0.030 Malignant neoplasm of stomach Identification of EGFR expression status association with metastatic lymph node ... BeFree,GAD 25154973 Detail
0.030 Malignant neoplasm of stomach Patients with HER2(+) /EGFR(+) /MET(+) GCs had a substantial risk of death with ... BeFree,GAD 25157953 Detail
0.030 Malignant neoplasm of stomach Knockdown of EGFR inhibits growth and invasion of gastric cancer cells. BeFree,GAD 25394504 Detail
0.030 Malignant neoplasm of stomach Gastric cancer in young vs old Romanian patients: immunoprofile with emphasis on... BeFree,GAD 25556597 Detail
0.030 Malignant neoplasm of stomach The prevalence of genomic copy number aberrations of epidermal growth factor rec... BeFree,GAD 25558650 Detail
0.030 Malignant neoplasm of stomach In addition, synergy in growth inhibition was observed when the GC cells were tr... BeFree,GAD 25576915 Detail
0.030 Malignant neoplasm of stomach The results demonstrated that EGFR phosphorylation was markedly inhibited in gas... BeFree,GAD 25625229 Detail
0.030 Malignant neoplasm of stomach Cetuximab, an immunoglobulin G1 chimeric monoclonal antibody directed against th... BeFree,GAD 25815786 Detail
0.030 Malignant neoplasm of stomach EGFR gene polymorphisms -216G>T and -191C>A are risk markers for gastric cancer ... BeFree,GAD 25867325 Detail
0.030 Malignant neoplasm of stomach In gastric cancer (GC), epidermal growth factor receptor (EGFR) overexpression a... BeFree,GAD 26318594 Detail
0.120 Animal Mammary Neoplasms NA CTD_human Detail
0.120 Mammary Neoplasms, Experimental NA CTD_human Detail
<0.001 Marijuana Abuse Higher expression of the EGFR cascade in cannabis smokers revealed that cannabis... BeFree 25736926 Detail
<0.001 measles NA BeFree Detail
0.002 medulloblastoma Overexpression of EGFR predicts poor outcomes of MBs, small cell GBMs and PNETs,... BeFree 24986561 Detail
0.023 melanoma Epigenetic changes of EGFR have an important role in BRAF inhibitor-resistant cu... BeFree,GAD,LHGDN 25243790 Detail
0.023 melanoma An inverse relationship between MITF, vemurafenib resistance, and EGFR was then ... BeFree,GAD,LHGDN 25789707 Detail
<0.001 multiple endocrine neoplasia type 2B NA BeFree Detail
0.002 meningioma NA BeFree Detail
0.129 Mesothelioma Regarding that also EGFR amplifications in MPM are absolute rarities, our findin... BeFree,CTD_human,LHGDN 25138167 Detail
0.008 Metaplasia NA LHGDN Detail
<0.001 Mixed Salivary Gland Tumor NA BeFree Detail
0.001 Monosomy NA BeFree Detail
0.008 Mouth Neoplasms NA GAD,LHGDN Detail
<0.001 multiple myeloma Multiple myeloma acquires resistance to EGFR inhibitor via induction of pentose ... BeFree 25894462 Detail
<0.001 Xeroderma Pigmentosum, Complementation Group D The germline polymorphisms studied were thymidylate synthase, (VNTR/5'UTR, 2R G&... BeFree 21570215 Detail
<0.001 Mycoplasma Infections NA BeFree Detail
<0.001 Nasal Polyps NA BeFree Detail
0.120 Nasopharyngeal Neoplasms NA CTD_human Detail
0.002 Neck Neoplasms NA BeFree Detail
<0.001 Neonatal hepatitis NA BeFree Detail
0.122 Neoplasm Invasiveness NA CTD_human,GAD Detail
0.002 rheumatoid arthritis Association of PTPN22 rs2476601 and EGFR rs17337023 Gene polymorphisms and rheum... BeFree 23350658 Detail
0.134 Neoplasm Recurrence, Local NA CTD_human,GAD Detail
0.002 Neoplasms, Glandular and Epithelial NA GAD Detail
0.001 nephroblastoma NA BeFree Detail
<0.001 Nesidioblastosis NA BeFree Detail
0.005 neurilemmoma NA BeFree,LHGDN Detail
0.003 neuroblastoma Using the Snapshot assay, mutation statuses were detected for EGFR, Kirsten rate... BeFree 24823994 Detail
0.003 neuroblastoma Clinically, EGFR inhibitors are ineffective as single agent compounds in patient... BeFree 25756510 Detail
0.001 neurofibroma Transgenic mice heterozygous for a Trp53-null allele and overexpressing EGFR in ... BeFree 24832557 Detail
0.001 neurofibromatosis 1 NA BeFree Detail
0.006 acoustic neuroma NA BeFree,LHGDN Detail
<0.001 Nevus NA BeFree Detail
<0.001 Melanocytic nevus NA BeFree Detail
0.001 Nodule For overall patients, EGFR mutation status was associated with gender, pStage, p... BeFree 25605150 Detail
<0.001 obesity NA BeFree Detail
0.007 oligodendroglioma NA BeFree,LHGDN Detail
0.003 Disorder of the optic nerve NA LHGDN Detail
0.137 osteosarcoma Thus, miR-143, EGFR, and MMP9 are therapeutic targets for inhibiting OS invasion... BeFree,CTD_human,GAD,LHGDN 25227664 Detail
0.002 Otorhinolaryngologic Neoplasms NA GAD Detail
0.024 ovarian carcinoma Yes-associated protein (YAP) has been reported to be associated with the prognos... BeFree 24770679 Detail
0.024 ovarian carcinoma The crosstalk between PAFR and EGFR suggests a potentially important signaling l... BeFree 25261977 Detail
0.024 ovarian carcinoma miR-491-5p-induced apoptosis in ovarian carcinoma depends on the direct inhibiti... BeFree 25299770 Detail
0.024 ovarian carcinoma We found that ErbB-1 was localized predominantly in the nucleus of ovarian cance... BeFree 25670170 Detail
0.024 ovarian carcinoma Of the two postulated miR-7 target genes we examined, BCL2, but not EGFR, seems ... BeFree 25862909 Detail
0.024 ovarian carcinoma Both epidermal growth factor receptor (EGFR) and fibroblast growth factor recept... BeFree 25919378 Detail
<0.001 Ovarian Cysts NA BeFree Detail
0.026 Pancreatic Neoplasm NA BeFree,GAD,LHGDN Detail
0.122 papilloma EGFR mutations were not identified in exophytic or oncocytic papillomas or non-I... BeFree,CTD_human 25931286 Detail
<0.001 pericardial effusion NA BeFree Detail
<0.001 Peripheral neuropathy NA BeFree Detail
<0.001 Peripheral Nervous System Neoplasms NA BeFree Detail
<0.001 Peutz-Jeghers syndrome NA BeFree Detail
<0.001 pituitary adenoma NA BeFree Detail
0.001 Pituitary Diseases NA BeFree Detail
0.004 Pituitary Neoplasms NA BeFree,LHGDN Detail
<0.001 plague NA BeFree Detail
0.006 Pleural effusion disorder It is feasible to detect the gene copy number of the pleural effusion cell mass ... BeFree,GAD 25635424 Detail
0.006 Pleural effusion disorder The results established the important role of HRM as a reliable and efficient me... BeFree,GAD 25674250 Detail
<0.001 Pleural Neoplasms NA BeFree Detail
<0.001 Staphylococcal Pneumonia NA BeFree Detail
<0.001 Pneumoperitoneum NA BeFree Detail
<0.001 Adenomatous Polyposis Coli NA BeFree Detail
0.001 polyps NA BeFree Detail
0.005 Precancerous Conditions NA BeFree,GAD Detail
<0.001 Pregnancy Complications NA BeFree Detail
<0.001 prolactinoma ErbB receptor-driven prolactinomas respond to targeted lapatinib treatment in fe... BeFree 25375038 Detail
0.144 Prostatic Neoplasms NA BeFree,CTD_human,LHGDN Detail
<0.001 Prurigo NA BeFree Detail
<0.001 Pruritus NA BeFree Detail
<0.001 pterygium NA BeFree Detail
0.082 pulmonary fibrosis NA BeFree,RGD Detail
<0.001 pyruvate carboxylase deficiency disease NA BeFree Detail
0.135 Rectal Neoplasms NA BeFree,CTD_human,GAD,LHGDN Detail
<0.001 kidney failure NA BeFree Detail
0.002 retinoblastoma Analysis of tumour samples and cell lines derived from resistant EGFR mutant pat... BeFree 25758528 Detail
<0.001 Retroviridae Infections NA BeFree Detail
0.001 rhabdomyosarcoma NA BeFree Detail
0.003 rhinitis NA LHGDN Detail
<0.001 Salivary Gland Neoplasms However, the results of phase II trials of EGFR inhibitors-as well as other targ... BeFree 26470903 Detail
<0.001 schistosomiasis NA BeFree Detail
<0.001 Seizures NA BeFree Detail
<0.001 seminoma NA BeFree Detail
<0.001 Dermatologic disorders NA BeFree Detail
0.004 Skin Neoplasms NA BeFree,LHGDN Detail
0.001 Soft Tissue Neoplasms NA BeFree Detail
<0.001 Splenic Neoplasms NA BeFree Detail
<0.001 Staphylococcal Infections NA BeFree Detail
<0.001 Stereotyped Behavior NA BeFree Detail
0.132 Stomach Neoplasms NA BeFree,CTD_human,LHGDN Detail
<0.001 gastric ulcer NA BeFree Detail
0.010 synovial sarcoma NA BeFree,LHGDN Detail
<0.001 synovitis NA BeFree Detail
<0.001 Testicular Neoplasms NA BeFree Detail
0.006 thymoma Does gefitinib have effects on EGFR mutation-positive thymoma? -Case report of t... BeFree,LHGDN 24492164 Detail
0.008 Thyroid Neoplasm NA BeFree,GAD,LHGDN Detail
0.080 Tobacco use disorder NA RGD Detail
0.002 Tonsillar Neoplasms NA GAD Detail
<0.001 tonsillitis NA BeFree Detail
<0.001 trigeminal neuralgia NA BeFree Detail
0.003 Trisomy NA BeFree Detail
<0.001 tuberculosis Gender-based impact of epidermal growth factor receptor mutation in patients wit... BeFree 25634180 Detail
<0.001 Tuberculosis, Pulmonary Comparing to male with pulmonary TB history, female with or without pulmonary TB... BeFree 25634180 Detail
<0.001 tuberous sclerosis NA BeFree Detail
<0.001 Unipolar Depression NA BeFree Detail
<0.001 uremia NA BeFree Detail
<0.001 Uterine Fibroids NA BeFree Detail
0.003 Uterine Neoplasms NA BeFree,LHGDN Detail
<0.001 Zollinger-Ellison syndrome NA BeFree Detail
<0.001 B-Cell Lymphomas Some miR-7 targets, including B-cell lymphoma 2 (BCL2) and epidermal growth fact... BeFree 25862909 Detail
0.010 Pleural Effusion, Malignant Frequency of EGFR mutations in lung adenocarcinoma with malignant pleural effusi... BeFree,GAD,LHGDN 25239875 Detail
0.010 Pleural Effusion, Malignant Sea-urchin-like Au nanocluster with surface-enhanced raman scattering in detecti... BeFree,GAD,LHGDN 25495142 Detail
<0.001 severe combined immunodeficiency NA BeFree Detail
0.002 Bronchial Hyperreactivity NA GAD Detail
<0.001 Central Nervous System Neoplasms NA BeFree Detail
0.003 hepatitis E NA LHGDN Detail
<0.001 Li-Fraumeni syndrome EGFR-mutated lung cancer in Li-Fraumeni syndrome. BeFree 25047674 Detail
<0.001 Li-Fraumeni syndrome We report two cases of non-smoker patients diagnosed with EGFR-mutated lung aden... BeFree 25433984 Detail
<0.001 Neurofibrillary degeneration (morphologic abnormality) NA BeFree Detail
0.003 Polycystic Kidney, Autosomal Dominant NA BeFree,LHGDN Detail
0.120 autosomal recessive polycystic kidney disease NA BeFree,CTD_human Detail
<0.001 Burning sensation NA BeFree Detail
<0.001 Alcohol abuse NA BeFree Detail
<0.001 cataract NA BeFree Detail
<0.001 benign neoplasm NA BeFree Detail
<0.001 Pancreatitis, Chronic NA BeFree Detail
<0.001 Epstein-Barr Virus Infections NA BeFree Detail
0.080 Left Ventricular Hypertrophy NA RGD Detail
0.005 Squamous cell carcinoma of lung Finally, an inverse correlation was observed between Fhit and phospho-EGFR level... BeFree 24464917 Detail
0.005 Squamous cell carcinoma of lung The initial set of trials will focus on different questions: (1) Exceptional Res... BeFree 24857062 Detail
0.005 Squamous cell carcinoma of lung Tumor-suppressive microRNA-206 as a dual inhibitor of MET and EGFR oncogenic sig... BeFree 25522678 Detail
0.005 Squamous cell carcinoma of lung We examined EGFR mutations in exons 19 and 21 in 147 NSCLC patients (excluding s... BeFree 25684509 Detail
0.005 Squamous cell carcinoma of lung Cell membrane CD44v6 levels in squamous cell carcinoma of the lung: association ... BeFree 25809603 Detail
0.005 Squamous cell carcinoma of lung Epidermal growth factor receptor gene mutation status in pure squamous-cell lung... BeFree 25886585 Detail
<0.001 Humoral hypercalcemia of malignancy (disorder) NA BeFree Detail
<0.001 Adenocarcinoma of rectum NA BeFree Detail
0.003 Oral Cavity Carcinoma NA BeFree,GAD Detail
<0.001 renal fibrosis NA BeFree Detail
<0.001 Cutaneous Melanoma Epigenetic changes of EGFR have an important role in BRAF inhibitor-resistant cu... BeFree 25243790 Detail
0.007 esophageal carcinoma Esophageal carcinoma cell line with high EGFR polysomy is responsive to gefitini... BeFree 25070024 Detail
0.009 Malignant neoplasm of mouth Inhibition of EGFR in pre-clinical models of oral pre-malignancies validates thi... BeFree,GAD 24412287 Detail
0.009 Malignant neoplasm of mouth Targeting Ley on EGFR could have a potential therapeutic effect on oral cancer. BeFree,GAD 25799278 Detail
0.001 Malignant neoplasm of oropharynx NA BeFree Detail
<0.001 Malignant neoplasm of nasopharynx NA BeFree Detail
<0.001 Malignant neoplasm of anus Anecdotal benefit from EGFR-targeted therapy has been reported in anal cancer an... BeFree 25244542 Detail
<0.001 Malignant neoplasm of gallbladder In conclusion, the present study indicated that the mechanism of action of miR-1... BeFree 25760482 Detail
<0.001 uterine cancer NA BeFree Detail
<0.001 Malignant neoplasm of fallopian tube NA BeFree Detail
<0.001 Malignant neoplasm of testis In this study, we analyzed the expression of MAGE-A, a cancer-testis antigen, in... BeFree 24866168 Detail
<0.001 Malignant neoplasm of penis NA BeFree Detail
0.005 Malignant neoplasm of brain NA BeFree,GAD Detail
0.004 Secondary malignant neoplasm of lung In multivariate analysis, lobulated margins (odds ratio, 4.815; 95% confidence i... BeFree 25575117 Detail
0.002 Secondary malignant neoplasm of bone Our findings support a model in which nuclear EGFR acts as a transcriptional rep... BeFree 26071255 Detail
<0.001 Stage 0 Breast Carcinoma NA BeFree Detail
<0.001 Middle Ear Cholesteatoma NA BeFree Detail
<0.001 Christ-Siemens-Touraine syndrome NA BeFree Detail
<0.001 acute intermittent porphyria NA BeFree Detail
<0.001 Neurofibromatoses NA BeFree Detail
<0.001 Dermatitis, Allergic Contact NA BeFree Detail
<0.001 Russell-Silver syndrome NA BeFree Detail
0.002 Agenesis of corpus callosum NA BeFree Detail
0.026 Tumor Progression Aberrant epidermal growth factor receptor (EGFR) signaling in non-small cell lun... BeFree 25174397 Detail
0.026 Tumor Progression ERBB2/HER2 belongs to the EGFR-family of receptor tyrosine kinases and its overe... BeFree 25596742 Detail
0.026 Tumor Progression One mechanism by which EGFR promotes tumor progression is by activating signal c... BeFree 25622907 Detail
0.026 Tumor Progression Epidermal growth factor receptor (EGFR) mutation is one of the hallmarks of canc... BeFree 25701783 Detail
0.026 Tumor Progression Activation of epidermal growth factor receptor (EGFR), which occurs in many type... BeFree 26280537 Detail
<0.001 Adenocarcinoma, Tubular NA BeFree Detail
<0.001 Anaplastic carcinoma NA BeFree Detail
<0.001 Carcinoma, Spindle-Cell NA BeFree Detail
<0.001 Undifferentiated carcinoma NA BeFree Detail
<0.001 Carcinomatosis NA BeFree Detail
<0.001 Dysplastic Nevus NA BeFree Detail
<0.001 Germ cell tumor NA BeFree Detail
<0.001 Sarcoma, Epithelioid NA BeFree Detail
0.003 thymic carcinoma NA BeFree Detail
0.004 Lung Diseases, Interstitial Epidermal growth factor receptor (EGFR) pathway genes and interstitial lung dise... BeFree 24819665 Detail
0.004 Lung Diseases, Interstitial The frequency of interstitial lung disease (ILD) of grade ≥3 was low (0.6-2.2%) ... BeFree 25704957 Detail
<0.001 Neuroectodermal Tumors NA BeFree Detail
<0.001 Lichen Planus, Oral NA BeFree Detail
<0.001 Leukoplakia, Hairy NA BeFree Detail
0.009 adenosquamous carcinoma NA BeFree,LHGDN Detail
<0.001 hepatoblastoma NA BeFree Detail
<0.001 pulmonary blastoma NA BeFree Detail
<0.001 endometrial stromal sarcoma NA BeFree Detail
0.003 angiomyolipoma NA BeFree,LHGDN Detail
<0.001 Giant Cell Tumor of Bone NA BeFree Detail
0.003 Sarcoma, Clear Cell NA BeFree,LHGDN Detail
<0.001 alveolar rhabdomyosarcoma NA BeFree Detail
<0.001 Rhabdomyosarcoma, Embryonal NA BeFree Detail
0.003 embryonal carcinoma NA BeFree,LHGDN Detail
0.001 Neuroectodermal Tumor, Primitive Overexpression of EGFR predicts poor outcomes of MBs, small cell GBMs and PNETs,... BeFree 24986561 Detail
<0.001 adrenal cortical adenoma NA BeFree Detail
0.002 Adenomatosis, Pulmonary NA GAD Detail
<0.001 Adenocarcinoma, Clear Cell NA BeFree Detail
<0.001 Follicular thyroid carcinoma NA BeFree Detail
<0.001 acinar cell carcinoma NA BeFree Detail
0.121 adrenocortical carcinoma NA BeFree,CTD_human Detail
0.005 mucoepidermoid carcinoma NA BeFree,LHGDN Detail
<0.001 Carcinoma, Neuroendocrine We identified 126 EGFR-mutated (21.8% of 578 successful genotyped cases) lung ca... BeFree 25700797 Detail
0.132 cholangiocarcinoma In this review article, we discuss the molecular aspects of CCA including the ro... BeFree,CTD_human,GAD,LHGDN 24420749 Detail
0.002 Cystadenocarcinoma, Mucinous NA GAD Detail
0.003 Cystadenocarcinoma, Serous NA BeFree,GAD Detail
0.002 Carcinoma, Giant Cell NA GAD Detail
0.004 Carcinoma, Large Cell A significantly higher incidence of EGFR mutations was observed in bronchioloalv... BeFree,GAD 25684509 Detail
0.003 verrucous carcinoma NA LHGDN Detail
0.003 Cervical Intraepithelial Neoplasia NA BeFree,GAD Detail
<0.001 ganglioglioma NA BeFree Detail
<0.001 ganglioneuroblastoma NA BeFree Detail
0.002 Squamous Cell Neoplasms NA GAD Detail
0.003 inverted papilloma NA BeFree,LHGDN Detail
0.121 gliosarcoma NA BeFree,ORPHANET Detail
0.004 Nerve Sheath Tumors Transgenic mice heterozygous for a Trp53-null allele and overexpressing EGFR in ... BeFree,LHGDN 24832557 Detail
<0.001 hemangioblastoma NA BeFree Detail
<0.001 Rhabdoid Tumor NA BeFree Detail
0.004 Neuroendocrine Tumors NA BeFree,LHGDN Detail
<0.001 childhood rhabdomyosarcoma NA BeFree Detail
<0.001 uveal melanoma NA BeFree Detail
<0.001 Malignant neoplasm of salivary gland NA BeFree Detail
0.005 Lip and oral cavity carcinoma Inhibition of EGFR in pre-clinical models of oral pre-malignancies validates thi... BeFree 24412287 Detail
0.005 Lip and oral cavity carcinoma Targeting Ley on EGFR could have a potential therapeutic effect on oral cancer. BeFree 25799278 Detail
0.001 Meningeal Carcinomatosis Our case suggests that dual targeting of epidermal growth factor receptor (EGFR)... BeFree 24999085 Detail
<0.001 Comedone NA BeFree Detail
<0.001 rapidly progressive glomerulonephritis NA BeFree Detail
<0.001 pituitary-dependent Cushing's disease NA BeFree Detail
<0.001 Lesion of brain NA BeFree Detail
<0.001 Neurologic Symptoms It represents a potential therapeutic option against LM after failure of standar... BeFree 25921002 Detail
<0.001 Thoracic lymphadenopathy ALK positive lung adenocarcinomas are more likely than EGFR mutant lung adenocar... BeFree 25312988 Detail
0.001 gallbladder carcinoma In conclusion, the present study indicated that the mechanism of action of miR-1... BeFree 25760482 Detail
0.024 pancreatic carcinoma EGFR has been implicated in various malignancies such as NSCLC, breast, head and... BeFree 24921970 Detail
0.024 pancreatic carcinoma Together, these studies provide further support for a role for EGFR and HER2 in ... BeFree 25117978 Detail
0.024 pancreatic carcinoma Lumican plays a restrictive role in EGFR-expressing pancreatic cancer progressio... BeFree 25336691 Detail
0.024 pancreatic carcinoma Low expression of the E3 ubiquitin ligase CBL confers chemoresistance in human p... BeFree 25348515 Detail
0.024 pancreatic carcinoma In conclusion, our studies will enhance the translational acquaintance of pan-EG... BeFree 25686822 Detail
0.024 pancreatic carcinoma Moreover, EGFR was found to mediate the REG3A signal for PaC cell growth and JAK... BeFree 25779676 Detail
<0.001 Carcinoma of male breast NA BeFree Detail
<0.001 fallopian tube carcinoma NA BeFree Detail
0.008 Gastrointestinal Stromal Tumors Targeting c-Kit plus HER1 or AXL/c-Met abrogates IM resistance in GIST. BeFree,LHGDN 25557174 Detail
<0.001 Lymphangitis carcinomatosa NA BeFree Detail
0.005 Cancer of Nasopharynx NA BeFree,GAD Detail
<0.001 Squamous cell carcinoma of penis NA BeFree Detail
<0.001 Female Pseudohermaphroditism Localisation of PTPD1 at the plasma membrane was mediated by its FERM domain and... BeFree 25062045 Detail
0.002 Anaplastic thyroid carcinoma NA BeFree Detail
0.002 Medullary carcinoma of thyroid NA BeFree Detail
0.002 Papillary thyroid carcinoma NA BeFree Detail
0.001 Fibrosis, Liver In conclusion, miR-214 appears to participate in the development of hepatic fibr... BeFree 26122702 Detail
<0.001 Squamous Papilloma of the Larynx NA BeFree Detail
0.005 Biliary calculi NA LHGDN Detail
0.080 Parkinsonian Disorders NA RGD Detail
0.120 Disease Progression NA CTD_human Detail
<0.001 Malignant neoplasm of male breast NA BeFree Detail
<0.001 Carcinoma, Lewis Lung NA BeFree Detail
<0.001 mixed gliomas NA BeFree Detail
<0.001 Carcinoma of ampulla of Vater NA BeFree Detail
0.004 Carcinoma, Small Cell NA BeFree,LHGDN Detail
0.120 Chloracne NA BeFree,CTD_human Detail
<0.001 Epithelial hyperplasia of skin NA BeFree Detail
<0.001 Disorder of skeletal system NA BeFree Detail
<0.001 Thickening of pleura NA BeFree Detail
<0.001 Greig cephalopolysyndactyly syndrome NA BeFree Detail
<0.001 Donohue syndrome NA BeFree Detail
<0.001 Xeroderma Pigmentosum, Complementation Group D NA BeFree Detail
<0.001 Simple renal cyst NA BeFree Detail
<0.001 Endometrioma NA BeFree Detail
<0.001 Parathyroid hyperplasia NA BeFree Detail
<0.001 Erythroblastosis NA BeFree Detail
<0.001 Rhinovirus infection NA BeFree Detail
<0.001 Malignant neoplasm of colon stage IV NA BeFree Detail
0.005 Carcinoma breast stage IV Epidermal growth factor receptor overexpression is a predictive factor for trast... BeFree 25349977 Detail
0.005 Carcinoma breast stage IV Resistance to the human epidermal growth factor receptor (HER2)-targeted antibod... BeFree 25391374 Detail
0.005 Carcinoma breast stage IV The antitumorigenic function of EGFR in metastatic breast cancer is regulated by... BeFree 25622905 Detail
<0.001 Breast cancer recurrent NA BeFree Detail
<0.001 Malignant neoplasm of stomach stage IV NA BeFree Detail
<0.001 Non-small cell lung cancer stage I NA BeFree Detail
<0.001 Non-small cell lung cancer stage III To determine the frequency and clinical significance of epidermal growth factor ... BeFree 25442336 Detail
<0.001 Metastatic osteosarcoma NA BeFree Detail
<0.001 Anal cancer recurrent NA BeFree Detail
<0.001 Cervical carcinoma stage IIB NA BeFree Detail
0.002 inflammatory breast carcinoma NA BeFree Detail
<0.001 Stage IV Ovarian Carcinoma NA BeFree Detail
<0.001 gastric adenocarcinoma Chromosome 7 polysomy may be responsible for EGFR gene amplifications, and we co... BeFree 25558650 Detail
<0.001 Recurrent Endometrial Cancer NA BeFree Detail
<0.001 Adenocarcinoma of small intestine Thus, we suggest that Musashi-1, Lgr5, and pEGFR are overexpressed in human SIAs... BeFree 25773390 Detail
<0.001 Prostate cancer recurrent NA BeFree Detail
<0.001 Thymoma malignant invasive NA BeFree Detail
<0.001 adult glioblastoma A randomised, open label phase III trial with nimotuzumab, an anti-epidermal gro... BeFree 25616647 Detail
<0.001 Metastatic melanoma NA BeFree Detail
<0.001 Melanoma recurrent An inverse relationship between MITF, vemurafenib resistance, and EGFR was then ... BeFree 25789707 Detail
0.026 Cancer of Head and Neck Targeting the epidermal growth factor receptor for head and neck cancer chemopre... BeFree,GAD 24412287 Detail
0.026 Cancer of Head and Neck Better anti-EGFR treatment efficacy was related to lower EGFR expression in head... BeFree,GAD 24780353 Detail
0.026 Cancer of Head and Neck Inhibition of EGFR or IGF-1R signaling enhances radiation response in head and n... BeFree,GAD 25355701 Detail
0.026 Cancer of Head and Neck Effective therapeutic approach for head and neck cancer by an engineered minibod... BeFree,GAD 25438047 Detail
0.026 Cancer of Head and Neck MyD88-Dependent Signaling Decreases the Antitumor Efficacy of Epidermal Growth F... BeFree,GAD 25712126 Detail
0.026 Cancer of Head and Neck The EGFR-targeted antibody cetuximab is effective against head and neck cancer (... BeFree,GAD 25832655 Detail
0.001 Liver and Intrahepatic Biliary Tract Carcinoma NA BeFree Detail
<0.001 Adenosquamous cell lung cancer EGFR gene mutations in patients with adenosquamous lung carcinoma. BeFree 24575772 Detail
0.002 Adenocarcinoma Of Esophagus We show for the first time a significant treatment response to the EGFR tyrosine... BeFree 25070024 Detail
0.002 Adenocarcinoma Of Esophagus Epidermal growth factor receptor (EGFR) is an independent adverse prognostic fac... BeFree 25216514 Detail
<0.001 anal carcinoma Anecdotal benefit from EGFR-targeted therapy has been reported in anal cancer an... BeFree 25244542 Detail
0.003 cervical squamous cell carcinoma NA BeFree,GAD Detail
<0.001 Transitional cell carcinoma of bladder NA BeFree Detail
<0.001 bladder adenocarcinoma NA BeFree Detail
0.001 Conventional (Clear Cell) Renal Cell Carcinoma NA BeFree Detail
<0.001 Adenocarcinoma of salivary gland NA BeFree Detail
<0.001 extraosseous Ewings sarcoma-primitive neuroepithelial tumor Overexpression of EGFR predicts poor outcomes of MBs, small cell GBMs and PNETs,... BeFree 24986561 Detail
<0.001 Carcinoid tumor of lung NA BeFree Detail
0.017 Solid tumour The initial set of trials will focus on different questions: (1) Exceptional Res... BeFree 24857062 Detail
0.017 Solid tumour Preclinical studies have shown synergism between epidermal growth factor recepto... BeFree 25590835 Detail
0.017 Solid tumour Cetuximab (anti-epidermal growth factor receptor - EGFR - monoclonal antibody) i... BeFree 25595386 Detail
0.017 Solid tumour Ubiquitous overexpression of wild type EGFR in many solid tumors has led to the ... BeFree 25658924 Detail
0.017 Solid tumour Eligible patients were aged at least 18 years with histologically confirmed, che... BeFree 26159065 Detail
0.002 stage, non-small cell lung cancer Molecular testing for epidermal growth factor receptor (EGFR) mutations is requi... BeFree 24831172 Detail
0.002 stage, non-small cell lung cancer Although surgical resection remains standard treatment for early stage non-small... BeFree 25152277 Detail
0.002 stage, non-small cell lung cancer Epidermal growth factor receptor tyrosine kinase inhibitors in early-stage nonsm... BeFree 25611026 Detail
0.002 stage, non-small cell lung cancer Statins augment efficacy of EGFR-TKIs in patients with advanced-stage non-small ... BeFree 25702091 Detail
<0.001 stage, pancreatic cancer NA BeFree Detail
<0.001 Squamous cell carcinoma of oropharynx NA BeFree Detail
<0.001 Squamous cell carcinoma of tonsil NA BeFree Detail
0.003 laryngeal squamous cell carcinoma NA BeFree Detail
<0.001 glottis squamous cell carcinoma Biopsy specimens of patients with glottic squamous cell carcinoma and simple hyp... BeFree 25279714 Detail
<0.001 high-grade childhood cerebral astrocytoma NA BeFree Detail
<0.001 uterine carcinosarcoma NA BeFree Detail
0.001 diffuse astrocytoma NA BeFree Detail
<0.001 Squamous cell carcinoma of vulva NA BeFree Detail
0.003 Adenocarcinoma of pancreas NA BeFree Detail
0.003 Prostatic Intraepithelial Neoplasias NA BeFree,LHGDN Detail
0.007 cervix carcinoma Studies in cervical cancer indicate that E5 increases epidermal growth factor re... BeFree 25027574 Detail
0.007 cervix carcinoma FTS is responsible for radiation-induced nuclear phosphorylation of EGFR and rep... BeFree 25151576 Detail
<0.001 Dryness of eye IL-6, IL-9, CCL24, CCL18, IL-10, IFN-γ, and CCL2 were highly increased (>6-fold)... BeFree 26200497 Detail
<0.001 Tumor necrosis NA BeFree Detail
0.001 High-Grade Squamous Intraepithelial Lesions NA BeFree Detail
<0.001 Hyperplastic Polyp NA BeFree Detail
0.001 pleomorphic carcinoma NA BeFree Detail
<0.001 Combined small cell carcinoma NA BeFree Detail
0.001 Squamous cell carcinoma, metastatic NA BeFree Detail
<0.001 Lymphoepithelial carcinoma NA BeFree Detail
<0.001 Schneiderian papilloma High-Frequency Targetable EGFR Mutations in Sinonasal Squamous Cell Carcinomas A... BeFree 25931286 Detail
0.002 adenocarcinoma in situ Adenocarcinoma in situ showed significantly higher DPD mRNA levels and more EGFR... BeFree 24405586 Detail
0.002 adenocarcinoma in situ The remaining 26 quadruple-negative tumors were significantly associated with AA... BeFree 25361983 Detail
<0.001 Adenocarcinoma, intestinal type NA BeFree Detail
<0.001 Fibrolamellar hepatocellular carcinoma NA BeFree Detail
<0.001 Carcinoid tumor no ICD-O subtype NA BeFree Detail
0.001 malignant fibrous histiocytoma NA BeFree Detail
<0.001 Teratoma, Malignant NA BeFree Detail
<0.001 Hydatidiform Mole, Partial NA BeFree Detail
0.007 anaplastic astrocytoma NA BeFree,GAD Detail
0.001 pilocytic astrocytoma NA BeFree Detail
0.120 giant cell glioblastoma NA ORPHANET Detail
0.002 anaplastic oligodendroglioma NA BeFree Detail
0.001 Adenocarcinoma of colon NA BeFree Detail
<0.001 Human papilloma virus infection NA BeFree Detail
<0.001 Asymptomatic human immunodeficiency virus infection NA BeFree Detail
<0.001 Carcinoma ex pleomorphic adenoma NA BeFree Detail
0.007 Malignant neoplasm of liver FLC overexpresses EGFR in comparison to hepatocellular cancer, suggesting that E... BeFree,GAD 23676344 Detail
<0.001 intrahepatic cholangiocarcinoma NA BeFree Detail
<0.001 Large cell carcinoma of lung NA BeFree Detail
0.002 malignant mesothelioma NA BeFree Detail
<0.001 Malignant Mesothelioma of Peritoneum NA BeFree Detail
<0.001 Breast Cancer, Familial NA BeFree Detail
<0.001 Endometrioid carcinoma ovary NA BeFree Detail
<0.001 cervical adenosquamous carcinoma NA BeFree Detail
<0.001 pituitary carcinoma NA BeFree Detail
0.001 Multiple malignancy NA BeFree Detail
0.026 Malignant neoplasm of pancreas EGFR has been implicated in various malignancies such as NSCLC, breast, head and... BeFree,GAD 24921970 Detail
0.026 Malignant neoplasm of pancreas Together, these studies provide further support for a role for EGFR and HER2 in ... BeFree,GAD 25117978 Detail
0.026 Malignant neoplasm of pancreas Lumican plays a restrictive role in EGFR-expressing pancreatic cancer progressio... BeFree,GAD 25336691 Detail
0.026 Malignant neoplasm of pancreas Low expression of the E3 ubiquitin ligase CBL confers chemoresistance in human p... BeFree,GAD 25348515 Detail
0.026 Malignant neoplasm of pancreas In conclusion, our studies will enhance the translational acquaintance of pan-EG... BeFree,GAD 25686822 Detail
0.026 Malignant neoplasm of pancreas Moreover, EGFR was found to mediate the REG3A signal for PaC cell growth and JAK... BeFree,GAD 25779676 Detail
<0.001 Disseminated Malignant Neoplasm NA BeFree Detail
<0.001 Early gastric cancer Female gender, tumor size, lymphovascular invasion and EGFR overexpression were ... BeFree 25593477 Detail
0.002 Squamous cell carcinoma of tongue These results suggested that ADAM10 is important in regulating the proliferation... BeFree 25333745 Detail
0.001 Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site Helicobacter pylori transactivates the epidermal growth factor receptor (EGFR) o... BeFree 25499189 Detail
<0.001 Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site NA BeFree Detail
<0.001 Malignant neoplasm of vulva NA BeFree Detail
0.034 Malignant neoplasm of prostate Recently, ETS-related gene (ERG) gene rearrangements, phosphatase tensin homolog... BeFree,GAD 24516518 Detail
0.034 Malignant neoplasm of prostate EGFR mediates docetaxel resistance in human castration-resistant prostate cancer... BeFree,GAD 24888374 Detail
0.034 Malignant neoplasm of prostate Human epidermal growth factor receptor family members (HER) such as EGFR and HER... BeFree,GAD 25000999 Detail
0.034 Malignant neoplasm of prostate We propose that the loss of miR-203 is a molecular link in the progression of pr... BeFree,GAD 25004126 Detail
0.034 Malignant neoplasm of prostate Among these modules, transcription Androgen Receptor (AR) nuclear signaling and ... BeFree,GAD 25080090 Detail
0.034 Malignant neoplasm of prostate Berberine targets epidermal growth factor receptor signaling to suppress prostat... BeFree,GAD 25394789 Detail
0.034 Malignant neoplasm of prostate In this manuscript, we will discuss an inducible EGFR model (v-ERB-B:ER) and its... BeFree,GAD 25453219 Detail
<0.001 Hematologic Neoplasms NA BeFree Detail
0.120 Craniofacial Abnormalities NA CTD_human Detail
<0.001 dermatofibrosarcoma protuberans NA BeFree Detail
<0.001 Troyer syndrome NA BeFree Detail
<0.001 thrombophilia NA BeFree Detail
<0.001 Dysplastic oral leukoplakia NA BeFree Detail
<0.001 Idiopathic crescentic glomerulonephritis NA BeFree Detail
<0.001 Chronic rejection of renal transplant NA BeFree Detail
0.003 lupus erythematosus NA BeFree,GAD Detail
<0.001 Skeletal dysplasia NA BeFree Detail
<0.001 Anaplastic Oligoastrocytoma NA BeFree Detail
0.006 endometrial carcinoma Evidence for different expression profiles for c-Met, EGFR, PTEN and the mTOR pa... BeFree 24811063 Detail
0.006 endometrial carcinoma These new findings about endometrial cancer suggest a potential for targeted the... BeFree 24820961 Detail
<0.001 Respiratory distress A 33-year-old pregnant mother exhibited a disseminated EGFR-mutated lung carcino... BeFree 24997732 Detail
0.003 Secondary malignant neoplasm of liver Patients with an EGFR mutation were more prone to having synchronous LM than pat... BeFree 25240517 Detail
<0.001 Necrotizing Enterocolitis NA BeFree Detail
<0.001 Fibrosis of bile duct NA BeFree Detail
0.002 Recurrent tumor NA BeFree Detail
<0.001 Bilateral cataracts (disorder) NA BeFree Detail
<0.001 Neurodegenerative Disorders NA BeFree Detail
0.015 Malignant neoplasm of esophagus NA BeFree,GAD Detail
0.005 Thyroid carcinoma NA BeFree Detail
0.001 Oropharyngeal disorders NA BeFree Detail
0.004 Squamous cell carcinoma of skin NA BeFree,GAD Detail
0.017 Malignant glioma Because STAT signaling is commonly activated in malignant gliomas as a result of... BeFree 25482928 Detail
0.017 Malignant glioma Development of Resistance to EGFR-Targeted Therapy in Malignant Glioma Can Occur... BeFree 25808866 Detail
<0.001 Cerebral metastasis NA BeFree Detail
<0.001 Tonsillar Carcinoma NA BeFree Detail
<0.001 primary sclerosing cholangitis Additionally, cholangiocytes from LPS-treated mouse livers and human primary scl... BeFree 25915403 Detail
0.002 Squamous cell carcinoma of mouth NA BeFree Detail
0.004 Osteosarcoma of bone Thus, miR-143, EGFR, and MMP9 are therapeutic targets for inhibiting OS invasion... BeFree 25227664 Detail
0.002 Carcinoma of larynx Higher expression of the EGFR cascade in cannabis smokers revealed that cannabis... BeFree 25736926 Detail
<0.001 Leukemogenesis NA BeFree Detail
0.001 Tumor Initiation NA BeFree Detail
0.026 prostate carcinoma Recently, ETS-related gene (ERG) gene rearrangements, phosphatase tensin homolog... BeFree 24516518 Detail
0.026 prostate carcinoma EGFR mediates docetaxel resistance in human castration-resistant prostate cancer... BeFree 24888374 Detail
0.026 prostate carcinoma Human epidermal growth factor receptor family members (HER) such as EGFR and HER... BeFree 25000999 Detail
0.026 prostate carcinoma We propose that the loss of miR-203 is a molecular link in the progression of pr... BeFree 25004126 Detail
0.026 prostate carcinoma Among these modules, transcription Androgen Receptor (AR) nuclear signaling and ... BeFree 25080090 Detail
0.026 prostate carcinoma Berberine targets epidermal growth factor receptor signaling to suppress prostat... BeFree 25394789 Detail
0.026 prostate carcinoma In this manuscript, we will discuss an inducible EGFR model (v-ERB-B:ER) and its... BeFree 25453219 Detail
0.001 CARCINOMA OF VULVA NA BeFree Detail
0.007 Epithelial ovarian cancer miR-491-5p-induced apoptosis in ovarian carcinoma depends on the direct inhibiti... BeFree,GAD 25299770 Detail
0.002 invasive cancer NA BeFree Detail
0.008 Progressive Neoplastic Disease Despite the efficacy and superiority of EGFR TKIs over chemotherapy as first-lin... BeFree 25176972 Detail
0.002 Refractory cancer NA BeFree Detail
<0.001 Sentinel node (disorder) NA BeFree Detail
<0.001 Stage IV Colorectal Cancer Although KRAS mutation has a predictive role in stage IV colorectal cancer (CRC)... BeFree 24889488 Detail
<0.001 Complete hydatidiform mole NA BeFree Detail
0.080 breast carcinoma A new class of protein cancer biomarker candidates: differentially expressed spl... BeFree 24802673 Detail
0.080 breast carcinoma Complete pharmacologic EGFR/HER2 inhibition is required to reverse Src-dependent... BeFree 24887236 Detail
0.080 breast carcinoma This is a revised case report of a 52 year old Caucasian female with Li-Fraumeni... BeFree 25047674 Detail
0.080 breast carcinoma We suggest that TJE is a new potential reagent for EGFR-targeted therapy and ant... BeFree 25051266 Detail
0.080 breast carcinoma The targeting of the hormone receptor, HER2 and EGFR1 in breast cancer will be r... BeFree 25051360 Detail
0.080 breast carcinoma The epidermal growth factor receptor (EGFR) is a member of the ErbB family that ... BeFree 25140053 Detail
0.080 breast carcinoma Here, we report a proof-of-concept experiment demonstrating that small peptides ... BeFree 25220456 Detail
0.080 breast carcinoma Our results showed that CD44 expression was significantly increased by epidermal... BeFree 25269647 Detail
0.080 breast carcinoma Prognostic and predictive values of EGFR overexpression and EGFR copy number alt... BeFree 25349977 Detail
0.080 breast carcinoma In both the primary cancers and the metastases, Claudin-4 was most frequently ex... BeFree 25417118 Detail
0.080 breast carcinoma BRCA1 regulation of epidermal growth factor receptor (EGFR) expression in human ... BeFree 25417703 Detail
0.080 breast carcinoma Because mutations within HER1/EGFR are predictive of response to tyrosine kinase... BeFree 25435280 Detail
0.080 breast carcinoma Oncogenic signaling in amphiregulin and EGFR-expressing PTEN-null human breast c... BeFree 25454348 Detail
0.080 breast carcinoma Coexpression of EGFR and HER2 has been associated with poor disease outcome, hig... BeFree 25510900 Detail
0.080 breast carcinoma While ERBB1, ERBB2 and ERBB3 are often overexpressed or activated in breast canc... BeFree 25516216 Detail
0.080 breast carcinoma We propose that miR-7 regulated pathways, including EGFR and Src kinase, represe... BeFree 25532106 Detail
0.080 breast carcinoma Estrogen-responsive genes most significantly influenced by cohesin were enriched... BeFree 25542856 Detail
0.080 breast carcinoma This study identifies mutant p53 as an essential player in ErbB2 and EGFR-mediat... BeFree 25573952 Detail
0.080 breast carcinoma TXNIP interaction with the Her-1/2 pathway contributes to overall survival in br... BeFree 25605021 Detail
0.080 breast carcinoma Lapatinib, a dual tyrosine kinase inhibitor that interrupts the epidermal growth... BeFree 25605188 Detail
0.080 breast carcinoma Amplified HER2, which encodes a member of the epidermal growth factor receptor (... BeFree 25605973 Detail
0.080 breast carcinoma Further understanding of the paradoxical function of EGFR between primary and me... BeFree 25622905 Detail
0.080 breast carcinoma Loss of catalytically functional PTPN14 increased the secretion of growth factor... BeFree 25690013 Detail
0.080 breast carcinoma More and more evidences demonstrate that androgen receptor (AR), epidermal growt... BeFree 25695063 Detail
0.080 breast carcinoma Epidermal growth factor receptor and AKT1 gene copy numbers by multi-gene fluore... BeFree 25702787 Detail
0.080 breast carcinoma A benzimidazole derivative exhibiting antitumor activity blocks EGFR and HER2 ac... BeFree 25766325 Detail
0.080 breast carcinoma To identify a prognostic signature for breast cancer, we performed DNA methylati... BeFree 25773928 Detail
0.080 breast carcinoma Kindlin-2 interacts with and stabilizes EGFR and is required for EGF-induced bre... BeFree 25790908 Detail
0.080 breast carcinoma Upregulation of HER3 has been found to be a major mechanism underlying drug resi... BeFree 25849870 Detail
0.080 breast carcinoma Endocrine therapy considerations in postmenopausal patients with hormone recepto... BeFree 25857348 Detail
0.080 breast carcinoma Correlation between p53 and epidermal growth factor receptor expression in breas... BeFree 25966200 Detail
0.080 breast carcinoma Using the MCF10A/MCF10CA1a Breast Cancer Progression Cell Line Model to Investig... BeFree 25969993 Detail
0.080 breast carcinoma Requirement of ERα and basal activities of EGFR and Src kinase in Cd-induced act... BeFree 26006730 Detail
0.080 breast carcinoma The majority of breast cancers present with estrogen receptor (ER)-positive and ... BeFree 26059247 Detail
0.080 breast carcinoma Thirty-two locally/systemically advanced breast cancers treated with first-line ... BeFree 26178788 Detail
0.001 Ewings sarcoma-primitive neuroectodermal tumor (PNET) Overexpression of EGFR predicts poor outcomes of MBs, small cell GBMs and PNETs,... BeFree 24986561 Detail
0.002 Malignant neoplasm of gastrointestinal tract NA BeFree Detail
0.003 CNS metastases Afatinib may therefore be an effective treatment for heavily pretreated patients... BeFree 25247337 Detail
0.014 Secondary malignant neoplasm of lymph node Moreover, the expression of miR-183-3p in tumor tissue was found to be associate... BeFree 24805982 Detail
0.014 Secondary malignant neoplasm of lymph node The overall analysis showed that higher expression of ALDH1A1 is associated with... BeFree 24938375 Detail
0.014 Secondary malignant neoplasm of lymph node Upregulation of EGFR expression is associated with lymph node metastases of GC, ... BeFree 25394504 Detail
0.014 Secondary malignant neoplasm of lymph node Female gender, tumor size, lymphovascular invasion and EGFR overexpression were ... BeFree 25593477 Detail
0.014 Secondary malignant neoplasm of lymph node Both Univariate (U) and COX multivariate (C) analyses revealed that high EGFR an... BeFree 25702787 Detail
0.014 Secondary malignant neoplasm of lymph node The COX-2(+)/EGFR(+) group was associated with tumor size (p=0.002), mitotic ind... BeFree 25964576 Detail
0.014 Secondary malignant neoplasm of lymph node TNBC had a lower lymph node metastasis rate but higher CK5/6 and EGFR expression... BeFree 25966200 Detail
0.025 colon carcinoma Here we show a clear correlation between the efficacy of anti-EGFR inhibitors wi... BeFree 24556630 Detail
0.025 colon carcinoma These results indicate that ERBB3 is a potential target for EGFR- and ERBB2-resi... BeFree 24970817 Detail
0.025 colon carcinoma Importantly, hyperactivation of SRC/EGFR signaling triggered by loss of PTPRO le... BeFree 25301722 Detail
0.025 colon carcinoma To elucidate the role of HMGA1 proteins in chemoresistance we analyzed resistanc... BeFree 25409711 Detail
0.025 colon carcinoma EZH2 inhibition enhances the efficacy of an EGFR inhibitor in suppressing colon ... BeFree 25535899 Detail
0.025 colon carcinoma KRAS mutations also induce anti-EGFR antibody resistance in adenocarcinoma such ... BeFree 25589625 Detail
0.025 colon carcinoma Mutations at the K-RAS locus in colon cancer cells are frequently associated wit... BeFree 25675084 Detail
0.025 colon carcinoma In contrast, forced expression of MITF in melanoma and colon cancer cells inhibi... BeFree 25789707 Detail
0.025 colon carcinoma Treatment of metastatic colon carcinoma with the anti-epidermal growth factor re... BeFree 25975014 Detail
0.022 stomach carcinoma The present study was to determine the role of KRAS status in EGFR antibody trea... BeFree 24467518 Detail
0.022 stomach carcinoma Many molecular pathways are currently under investigation as therapeutic targets... BeFree 24587678 Detail
0.022 stomach carcinoma These results support the involvement of EGFR and HER2 in gastric cancer and sug... BeFree 24728052 Detail
0.022 stomach carcinoma Inhibition of epidermal growth factor receptor signaling prohibits metastasis of... BeFree 25085584 Detail
0.022 stomach carcinoma Identification of EGFR expression status association with metastatic lymph node ... BeFree 25154973 Detail
0.022 stomach carcinoma Patients with HER2(+) /EGFR(+) /MET(+) GCs had a substantial risk of death with ... BeFree 25157953 Detail
0.022 stomach carcinoma Knockdown of EGFR inhibits growth and invasion of gastric cancer cells. BeFree 25394504 Detail
0.022 stomach carcinoma Gastric cancer in young vs old Romanian patients: immunoprofile with emphasis on... BeFree 25556597 Detail
0.022 stomach carcinoma The prevalence of genomic copy number aberrations of epidermal growth factor rec... BeFree 25558650 Detail
0.022 stomach carcinoma In addition, synergy in growth inhibition was observed when the GC cells were tr... BeFree 25576915 Detail
0.022 stomach carcinoma The results demonstrated that EGFR phosphorylation was markedly inhibited in gas... BeFree 25625229 Detail
0.022 stomach carcinoma Cetuximab, an immunoglobulin G1 chimeric monoclonal antibody directed against th... BeFree 25815786 Detail
0.022 stomach carcinoma EGFR gene polymorphisms -216G>T and -191C>A are risk markers for gastric cancer ... BeFree 25867325 Detail
0.022 stomach carcinoma In gastric cancer (GC), epidermal growth factor receptor (EGFR) overexpression a... BeFree 26318594 Detail
0.014 Carcinoma of bladder EGFR as a potential therapeutic target for a subset of muscle-invasive bladder c... BeFree 25009231 Detail
0.014 Carcinoma of bladder Dual regulation of receptor tyrosine kinase genes EGFR and c-Met by the tumor-su... BeFree 25405368 Detail
0.014 Carcinoma of bladder The epidermal growth factor receptor (EGFR) family is reportedly overexpressed i... BeFree 25482142 Detail
<0.001 skin carcinoma NA BeFree Detail
0.003 Central neuroblastoma Using the Snapshot assay, mutation statuses were detected for EGFR, Kirsten rate... BeFree 24823994 Detail
0.003 Central neuroblastoma Clinically, EGFR inhibitors are ineffective as single agent compounds in patient... BeFree 25756510 Detail
0.004 Dissecting aneurysm of the thoracic aorta To show additional prognostic information about the mutational profile and new I... BeFree 25833149 Detail
0.004 Dissecting aneurysm of the thoracic aorta A prospective, multicentre phase II trial of low-dose erlotinib in non-small cel... BeFree 26174465 Detail
<0.001 Carcinoma of glottis The aim of the present study was to examine EGFR on protein level, confronting c... BeFree 25279714 Detail
<0.001 bile duct carcinoma NA BeFree Detail
<0.001 germ cell cancer NA BeFree Detail
0.004 Malignant neoplasm of kidney Lung and renal cancer, two areas in which huge progress has been made in the las... BeFree 25338550 Detail
0.004 Malignant neoplasm of kidney Molecular interaction of a kinase inhibitor midostaurin with anticancer drug tar... BeFree 25789858 Detail
<0.001 cervical cancer metastasis NA BeFree Detail
<0.001 early pregnancy The epidermal growth factor receptor critically regulates endometrial function d... BeFree 24945252 Detail
<0.001 Multiple Pulmonary Nodules NA BeFree Detail
<0.001 Arnold-Chiari Malformation, Type I NA BeFree Detail
0.003 biliary tract cancer TCDC also increased the expression of epidermal growth factor receptor (EGFR) li... BeFree 24839254 Detail
<0.001 Brain Tumor, Primary NA BeFree Detail
<0.001 Primary malignant neoplasm of brain NA BeFree Detail
0.004 Well Differentiated Oligodendroglioma NA BeFree Detail
<0.001 Malignant neoplasm tonsil NA BeFree Detail
<0.001 lymphangioleiomyomatosis Anti-EGFR antibody reduces lung nodules by inhibition of EGFR-pathway in a model... BeFree 25699271 Detail
0.002 Malignant Squamous Cell Neoplasm NA BeFree Detail
<0.001 peripheral nerve sheath neoplasm NA BeFree Detail
0.004 malignant peripheral nerve sheath tumor Transgenic mice heterozygous for a Trp53-null allele and overexpressing EGFR in ... BeFree 24832557 Detail
0.003 malignant pleural mesothelioma Next, the identification of less EGFR mutations in the EGFR gene of the pleural ... BeFree 25679064 Detail
<0.001 Helicobacter pylori infection NA BeFree Detail
0.001 Smoker's lung NA BeFree Detail
<0.001 In situ cancer NA BeFree Detail
<0.001 penis carcinoma NA BeFree Detail
0.003 Invasive breast carcinoma NA BeFree Detail
<0.001 Metastases to adrenals NA BeFree Detail
0.002 Rhabdoid Tumor of the Kidney RTK expression (c-Kit, c-Met, AXL, HER-1, HER-2, IGF-1R) in pre-/post-imatinib (... BeFree 25557174 Detail
<0.001 Lung adenocarcinoma recurrent NA BeFree Detail
0.001 Adenocarcinoma of lung, stage I Correlations Between the EGFR Mutation Status and Clinicopathological Features o... BeFree 26496308 Detail
<0.001 Recurrent Lung Carcinoma Cell Type Unspecified NA BeFree Detail
<0.001 breast adenocarcinoma NA BeFree Detail
<0.001 Pancreatic adenocarcinoma metastatic NA BeFree Detail
<0.001 Recurrent lung cancer NA BeFree Detail
<0.001 Lung cancer stage I NA BeFree Detail
0.001 Advanced cancer The initial set of trials will focus on different questions: (1) Exceptional Res... BeFree 24857062 Detail
<0.001 Intraepithelial Neoplasia NA BeFree Detail
<0.001 Stromal Neoplasm NA BeFree Detail
0.158 ovarian neoplasm NA BeFree,CTD_human,GAD,LHGDN Detail
<0.001 cancer recurrence NA BeFree Detail
0.001 Metastatic Prostate Carcinoma Activation of EGFR signaling pathway leads to prostate cancer bone metastasis; h... BeFree 25004126 Detail
<0.001 precancerous lesions NA BeFree Detail
0.005 Acute coronary syndrome NA BeFree,GAD,LHGDN Detail
<0.001 salivary gland carcinoma NA BeFree Detail
<0.001 Hurthle Cell Tumor NA BeFree Detail
0.002 Papillomavirus Infections NA GAD Detail
<0.001 Arthritis, Collagen-Induced NA BeFree Detail
0.120 Arthritis, Experimental NA CTD_human Detail
<0.001 Bronchial dysplasia NA BeFree Detail
0.001 Invasive Ductal Breast Carcinoma Strong adverse effect of epidermal growth factor receptor 2 overexpression on pr... BeFree 25804795 Detail
<0.001 Gestational Trophoblastic Neoplasms NA BeFree Detail
0.021 Malignant neoplasm of ovary Yes-associated protein (YAP) has been reported to be associated with the prognos... BeFree 24770679 Detail
0.021 Malignant neoplasm of ovary The crosstalk between PAFR and EGFR suggests a potentially important signaling l... BeFree 25261977 Detail
0.021 Malignant neoplasm of ovary We found that ErbB-1 was localized predominantly in the nucleus of ovarian cance... BeFree 25670170 Detail
0.021 Malignant neoplasm of ovary Of the two postulated miR-7 target genes we examined, BCL2, but not EGFR, seems ... BeFree 25862909 Detail
0.021 Malignant neoplasm of ovary Both epidermal growth factor receptor (EGFR) and fibroblast growth factor recept... BeFree 25919378 Detail
<0.001 respiratory failure NA BeFree Detail
0.001 endometrial adenocarcinoma NA BeFree Detail
0.004 Skin toxicity Gene regulatory biomarker identification for skin toxicities induced by EGFR inh... BeFree 26521924 Detail
<0.001 High-Grade Prostatic Intraepithelial Neoplasia NA BeFree Detail
0.163 Squamous cell carcinoma of the head and neck HRAS mutations and resistance to the epidermal growth factor receptor tyrosine k... BeFree,CLINVAR 24123531 Detail
0.163 Squamous cell carcinoma of the head and neck If ultimately shown to reduce the risk of oral cancer, chemoprevention with EGFR... BeFree,CLINVAR 24412287 Detail
0.163 Squamous cell carcinoma of the head and neck Influence of epidermal growth factor receptor expression on the cetuximab and pa... BeFree,CLINVAR 24780353 Detail
0.163 Squamous cell carcinoma of the head and neck Increased growth-inhibitory and cytotoxic activity of arsenic trioxide in head a... BeFree,CLINVAR 24927258 Detail
0.163 Squamous cell carcinoma of the head and neck Targeted therapy against the epidermal growth factor receptor (EGFR) only variab... BeFree,CLINVAR 24993889 Detail
0.163 Squamous cell carcinoma of the head and neck The tumor antigen (TA)-targeted monoclonal antibodies (mAb) cetuximab and panitu... BeFree,CLINVAR 24997207 Detail
0.163 Squamous cell carcinoma of the head and neck These findings underscore the importance of ADAM17 and suggest that D1(A12) migh... BeFree,CLINVAR 25013379 Detail
0.163 Squamous cell carcinoma of the head and neck The expression and subcellular localization of β-catenin and EGFR activation wer... BeFree,CLINVAR 25209444 Detail
0.163 Squamous cell carcinoma of the head and neck The epidermal growth factor receptor (EGFR) is a transmembrane tyrosine kinase r... BeFree,CLINVAR 25255959 Detail
0.163 Squamous cell carcinoma of the head and neck We investigated the effects of cetuximab (EGFR antibody) and IMC-A12 (IGF-1R ant... BeFree,CLINVAR 25355701 Detail
0.163 Squamous cell carcinoma of the head and neck Identification of epidermal growth factor receptor (EGFR) genetic variants that ... BeFree,CLINVAR 25511740 Detail
0.163 Squamous cell carcinoma of the head and neck We show that upon EGF stimulation, EGFR and RhoC were strongly activated in HNSC... BeFree,CLINVAR 25622907 Detail
0.163 Squamous cell carcinoma of the head and neck Further, large scale automated alignment of sequencing are unlikely to identify ... BeFree,CLINVAR 25658924 Detail
0.163 Squamous cell carcinoma of the head and neck However, many patients with HNSCC respond poorly to the EGFR inhibitors (EGFRI) ... BeFree,CLINVAR 25712126 Detail
0.163 Squamous cell carcinoma of the head and neck Epidermal growth factor receptor (EGFR) and its downstream elements are overexpr... BeFree,CLINVAR 25736926 Detail
0.163 Squamous cell carcinoma of the head and neck Cetuximab is the only approved molecular targeting agent for HNSCC and despite u... BeFree,CLINVAR 25826749 Detail
0.163 Squamous cell carcinoma of the head and neck To date, cetuximab is the only FDA-approved anti-epidermal growth factor recepto... BeFree,CLINVAR 25967534 Detail
0.001 Ductal Carcinoma Breast cancer 1 (BRCA1)-associated breast cancers are mostly basal-like high-gra... BeFree 25417703 Detail
0.001 Ductal Carcinoma Short telomere lengths have been previously associated with triple-negative and ... BeFree 26092192 Detail
<0.001 Mammary Carcinoma, Human NA BeFree Detail
<0.001 Dendritic Cell Sarcoma, Follicular NA BeFree Detail
0.012 sarcoma EGFR (exons 18-21) and Kirsten RNA-associated rat sarcoma 2 virus (exon 2) mutat... BeFree,LHGDN 24993594 Detail
0.012 sarcoma Compared with patients with ALK(-) lung adenocarcinomas (33 patients; 12 with ep... BeFree,LHGDN 25557162 Detail
<0.001 large cell neuroendocrine carcinoma De novo pulmonary small cell carcinomas and large cell neuroendocrine carcinomas... BeFree 25700797 Detail
<0.001 Non-small cell carcinoma NA BeFree Detail
<0.001 Nonseminomatous germ cell tumor NA BeFree Detail
<0.001 major depressive disorder NA BeFree Detail
<0.001 Multiple basal cell papillomata NA BeFree Detail
<0.001 acute interstitial pneumonia NA BeFree Detail
<0.001 Disorder of skull NA BeFree Detail
0.002 Single tumor Thus, the association between diverse activating mutations in EGFR and other sub... BeFree 24893890 Detail
0.002 Single tumor Surprisingly, the authors identify convergent evolution of multiple, mutually ex... BeFree 25092745 Detail
<0.001 Salivary duct carcinoma NA BeFree Detail
<0.001 Adenoma of large intestine NA BeFree Detail
<0.001 Low Grade Squamous Intraepithelial Neoplasia NA BeFree Detail
<0.001 ACTH-secreting pituitary adenoma NA BeFree Detail
<0.001 Astrocytoma, low grade NA BeFree Detail
<0.001 Liver regeneration disorder NA BeFree Detail
<0.001 Asthmatic bronchitis NA BeFree Detail
0.003 Adenocarcinoma of large intestine The aim of this study was to compare colorectal adenocarcinoma with mucinous com... BeFree 25907382 Detail
<0.001 Squamous cell carcinoma of pharynx NA BeFree Detail
<0.001 Anaplastic large B-cell lymphoma EGFR(epidermal growth factor receptor) mutations and ALK(anaplastic lymphoma kin... BeFree 24727987 Detail
<0.001 Thymoma, type C NA BeFree Detail
0.001 Hormone refractory prostate cancer NA BeFree Detail
<0.001 adult astrocytic tumors NA BeFree Detail
<0.001 Cerebellar Glioblastoma All of the cases of six cerebellar GBMs were p53‑positive and EGFR‑negative, as ... BeFree 25199771 Detail
<0.001 Esophageal Basaloid Carcinoma NA BeFree Detail
<0.001 Hereditary Nonpolyposis Colorectal Cancer NA BeFree Detail
<0.001 Infiltrating Cervical Carcinoma NA BeFree Detail
<0.001 Invasive Apocrine Breast Carcinoma NA BeFree Detail
<0.001 Invasive Carcinoma NA BeFree Detail
<0.001 Infiltrating Bladder Urothelial Carcinoma NA BeFree Detail
<0.001 pulmonary sclerosing hemangioma NA BeFree Detail
<0.001 Malignant Mixed Mesodermal (Mullerian) Tumor NA BeFree Detail
<0.001 Malignant Phyllodes Tumor of Prostate NA BeFree Detail
<0.001 Metaplastic breast carcinoma NA BeFree Detail
<0.001 Mucinous Neoplasm NA BeFree Detail
<0.001 Ovarian Serous Adenocarcinoma Ovarian serous carcinomas (n=112) and solid metastases (n=63; total=175) were an... BeFree 26232338 Detail
0.005 pancreatic ductal adenocarcinoma Cotargeting of epidermal growth factor receptor and PI3K overcomes PI3K-Akt onco... BeFree 24895459 Detail
0.005 pancreatic ductal adenocarcinoma Previous studies have demonstrated that combinatorial treatment of PDAC xenograf... BeFree 25117978 Detail
0.005 pancreatic ductal adenocarcinoma Inactivating Sox9 expression in mice confirmed its role in PDAC initiation; it d... BeFree 25336113 Detail
0.005 pancreatic ductal adenocarcinoma These results suggest that dysregulation of ubiquitination is a key mechanism of... BeFree 25348515 Detail
0.005 pancreatic ductal adenocarcinoma (i) hERG1 was expressed at high levels in 59% of primary PDAC; (ii) hERG1 blocka... BeFree 25719829 Detail
0.005 pancreatic ductal adenocarcinoma Proteomic analysis evidenced that MEK1 inhibition was accompanied by a sustained... BeFree 25736685 Detail
<0.001 Mucoepidermoid carcinoma of parotid gland NA BeFree Detail
<0.001 periampullary adenocarcinoma NA BeFree Detail
<0.001 Prostate Phyllodes Tumor NA BeFree Detail
0.001 Primary Carcinoma NA BeFree Detail
<0.001 Squamous Lung Dysplasia NA BeFree Detail
<0.001 Stage IB Lung Adenocarcinoma We proposed to investigate the distribution of concurrent oncogene mutations in ... BeFree 25546673 Detail
<0.001 Supratentorial Glioblastoma NA BeFree Detail
<0.001 supratentorial primitive neuroectodermal tumor NA BeFree Detail
<0.001 differentiated thyroid gland carcinoma NA BeFree Detail
<0.001 pineal parenchymal tumor of intermediate differentiation NA BeFree Detail
<0.001 Mixed Neoplasm NA BeFree Detail
<0.001 Hypopharyngeal Carcinoma NA BeFree Detail
0.006 Epithelioma NA BeFree Detail
<0.001 mature teratoma NA BeFree Detail
<0.001 Anal cancer metastatic NA BeFree Detail
<0.001 Granulosa cell tumor of the ovary NA BeFree Detail
<0.001 Liposarcoma, well differentiated NA BeFree Detail
0.001 peritoneal mesothelioma EGFR mutations were previously found in patients suffering from peritoneal mesot... BeFree 25679064 Detail
<0.001 Pleural Mesothelioma Next, the identification of less EGFR mutations in the EGFR gene of the pleural ... BeFree 25679064 Detail
0.004 renal carcinoma Lung and renal cancer, two areas in which huge progress has been made in the las... BeFree 25338550 Detail
0.004 renal carcinoma Molecular interaction of a kinase inhibitor midostaurin with anticancer drug tar... BeFree 25789858 Detail
<0.001 Metastatic Carcinoma NA BeFree Detail
<0.001 Primary Lesion In addition to the well-known characteristics of patients carrying EGFR mutation... BeFree 25442336 Detail
<0.001 anal squamous cell carcinoma NA BeFree Detail
<0.001 Benign melanocytic nevus NA BeFree Detail
0.215 Mammary Neoplasms For example, CDH3 was significantly up-regulated in the stromals of both breast ... BeFree,CTD_human,GAD,LHGDN 25826086 Detail
0.215 Mammary Neoplasms Positive Interplay Between CD3+ T-lymphocytes and Concurrent COX-2/EGFR Expressi... BeFree,CTD_human,GAD,LHGDN 25964576 Detail
<0.001 Breast Cancer Model Epidermal growth factor-receptor activation modulates Src-dependent resistance t... BeFree 24887236 Detail
0.001 Hepatocarcinogenesis Impact of epidermal growth factor receptor and transforming growth factor-α on h... BeFree 26279457 Detail
<0.001 Mammary Tumorigenesis Mutant p53 Amplifies Epidermal Growth Factor Receptor Family Signaling to Promot... BeFree 25573952 Detail
0.003 Primary Glioblastoma Correlation between EGFR amplification and the expression of microRNA-200c in pr... BeFree 25058589 Detail
<0.001 Primary Peritoneal Carcinoma NA BeFree Detail
<0.001 Prostate Basal Cell Carcinoma Basal cell carcinoma of the prostate is an aggressive tumor with frequent loss o... BeFree 25870120 Detail
0.002 Cancer Cell Growth NA BeFree Detail
<0.001 Secondary Glioblastoma NA BeFree Detail
<0.001 Tumor-Associated Vasculature NA BeFree Detail
0.003 Tumor Angiogenesis In this study, the role of EGFR in tumor angiogenesis was examined in H292 NSCLC... BeFree 25272226 Detail
0.003 Tumor Angiogenesis EGFR is involved in the tumor angiogenesis of HNSCC via the HIF-1α and Notch1 pa... BeFree 25723392 Detail
0.008 Xenograft Model Association of EGFR expression level and cetuximab activity in patient-derived x... BeFree 24947928 Detail
0.008 Xenograft Model Moreover, combined therapeutic inhibition of EGFR and c-Kit may abrogate this ac... BeFree 25510664 Detail
0.008 Xenograft Model In vivo studies using mouse xenograft models of CRC showed that Erbin promotes t... BeFree 25521828 Detail
0.008 Xenograft Model We engineered the human NSCLC cell line PC-9 (MET-positive cells harboring an ex... BeFree 25522765 Detail
<0.001 Ductal Breast Carcinoma Breast cancer 1 (BRCA1)-associated breast cancers are mostly basal-like high-gra... BeFree 25417703 Detail
<0.001 Ductal Breast Carcinoma Short telomere lengths have been previously associated with triple-negative and ... BeFree 26092192 Detail
0.001 Neoplasms, Intracranial Approaches used in this investigation include: bioluminescence imaging (BLI) for... BeFree 25313012 Detail
<0.001 Rectal Tumors NA BeFree Detail
0.003 Rash and Dermatitis Adverse Event Associated with Chemoradiation NA BeFree Detail
<0.001 Non-Malignant Ascites Adverse Event NA BeFree Detail
<0.001 Chronic Kidney Diseases NA BeFree Detail
<0.001 Adenocarcinoma, Endometrioid NA BeFree Detail
0.031 Glioblastoma multiforme Interestingly, the extent of these SHP2 signaling regulatory functions is dimini... BeFree,GAD 24951116 Detail
0.031 Glioblastoma multiforme These findings may explain reports on the common occurrence of mutant EGFR (EGFR... BeFree,GAD 25053824 Detail
0.031 Glioblastoma multiforme Whole genome sequencing of glioblastoma multiforme identifies multiple structura... BeFree,GAD 25103728 Detail
0.031 Glioblastoma multiforme Although EGFR phosphorylation and STAT3 activation are essential for the mainten... BeFree,GAD 25313011 Detail
0.031 Glioblastoma multiforme Tf-NP-miR-1 treatment on GBM spheres significantly inhibited migration of GBM sp... BeFree,GAD 25374033 Detail
0.031 Glioblastoma multiforme Together with our previous findings, these data suggest that GRh2 may suppress G... BeFree,GAD 25431263 Detail
0.031 Glioblastoma multiforme EGFR gene amplification also represents a signature of genetic abnormality in GB... BeFree,GAD 25576921 Detail
0.031 Glioblastoma multiforme Elevated expression of Notch-1 and EGFR induced apoptosis in glioblastoma multif... BeFree,GAD 25704190 Detail
0.031 Glioblastoma multiforme A common characteristic of glioblastoma multiforme histology is EGFR amplificati... BeFree,GAD 25760022 Detail
0.031 Glioblastoma multiforme Endogenous expressions of EGFR in various GBM cells were determined by western b... BeFree,GAD 25886314 Detail
<0.001 Cirrhosis By immunohistochemistry EGFR and TGF-α were overexpressed in HCC and cirrhotic c... BeFree 26279457 Detail
0.002 androgen independent prostate cancer NA BeFree Detail
0.004 Metastatic Malignant Neoplasm to the Leptomeninges Erlotinib combined with pemetrexed/cisplatin may be effective in the treatment o... BeFree 24985049 Detail
0.004 Metastatic Malignant Neoplasm to the Leptomeninges It represents a potential therapeutic option against LM after failure of standar... BeFree 25921002 Detail
0.001 Benign Prostatic Hyperplasia NA BeFree Detail
<0.001 Uterine Corpus Carcinosarcoma NA BeFree Detail
<0.001 Intimal sarcoma NA BeFree Detail
<0.001 lung sarcomatoid carcinoma NA BeFree Detail
0.002 Non-Neoplastic Disorder NA BeFree Detail
<0.001 sinonasal undifferentiated carcinoma NA BeFree Detail
<0.001 carcinosarcoma of lung NA BeFree Detail
0.001 Meningioma, benign, no ICD-O subtype NA BeFree Detail
<0.001 Idiopathic Pulmonary Fibrosis NA BeFree Detail
<0.001 rippling muscle disease 1 NA BeFree Detail
<0.001 Familial ependymoma NA BeFree Detail
0.001 Myeloproliferative disorder, chronic, with eosinophilia EGFR mutations may play an important role in the formation of MPE. BeFree 25239875 Detail
0.001 Myeloproliferative disorder, chronic, with eosinophilia SERS measurement based on sea-urchin-like AuNC was an efficient method for EGFR ... BeFree 25495142 Detail
0.001 Myeloproliferative disorder, chronic, with eosinophilia Metastatic RET-rearranged lung adenocarcinoma patients with MPE might have favor... BeFree 25773866 Detail
<0.001 Rippling muscle disease NA BeFree Detail
<0.001 ALKALINE PHOSPHATASE, PLASMA LEVEL OF, QUANTITATIVE TRAIT LOCUS 1 NA BeFree Detail
0.004 uterine corpus cancer These new findings about endometrial cancer suggest a potential for targeted the... BeFree 24820961 Detail
<0.001 low grade glioma The protein expression of PCNA and EGFR was significantly higher in high-grade t... BeFree 25688509 Detail
<0.001 Urothelial Carcinoma NA BeFree Detail
0.145 liver carcinoma This study suggests that γ-H2AX is associated with angiogenesis of HCC and γ-H2A... BeFree,CTD_human,GAD,LHGDN 25537504 Detail
0.145 liver carcinoma B3GNT2, a polylactosamine synthase, regulates glycosylation of EGFR in H7721 hum... BeFree,CTD_human,GAD,LHGDN 25605193 Detail
0.145 liver carcinoma UNC50 prompts G1/S transition and proliferation in HCC by regulation of epiderma... BeFree,CTD_human,GAD,LHGDN 25738771 Detail
0.145 liver carcinoma These results suggested that ECHS1 may promote cell proliferation in HCC in an E... BeFree,CTD_human,GAD,LHGDN 25760819 Detail
0.145 liver carcinoma Overexpression of EGFR in HCC patients can be promising in selecting those who c... BeFree,CTD_human,GAD,LHGDN 26279457 Detail
<0.001 Triple-negative breast carcinoma NA BeFree Detail
0.002 Oropharyngeal Carcinoma NA BeFree Detail
0.200 Acute kidney injury NA CTD_human,RGD Detail
<0.001 Merkel Cell Polyomavirus Infection NA BeFree Detail
<0.001 Steatohepatitis NA BeFree Detail
<0.001 Promyelocytic leukemia NA BeFree Detail
<0.001 Human Papillomavirus Positive Oropharyngeal Squamous Cell Carcinoma Expression levels of p16, β-catenin, and epidermal growth factor receptor (EGFR)... BeFree 25209444 Detail
<0.001 Gestational trophoblastic disease NA BeFree Detail
0.005 Nasopharyngeal carcinoma NA BeFree Detail
0.005 Prostatic Hyperplasia NA GAD,LHGDN Detail
<0.001 Pregnancy Related Skin Change NA BeFree Detail
<0.001 Early-Stage Breast Carcinoma NA BeFree Detail
<0.001 Stage IV Colorectal Cancer AJCC v7 Although KRAS mutation has a predictive role in stage IV colorectal cancer (CRC)... BeFree 24889488 Detail
<0.001 Combined large cell neuroendocrine carcinoma We assume that the LCNEC originated from the adenocarcinoma based on the fact th... BeFree 23518631 Detail
<0.001 Serrated polyp NA BeFree Detail
0.008 Progressive cGVHD Despite the efficacy and superiority of EGFR TKIs over chemotherapy as first-lin... BeFree 25176972 Detail
0.015 Triple Negative Breast Neoplasms Triple-negative breast cancer (TNBC) is a distinct breast cancer subtype defined... BeFree 24786829 Detail
0.015 Triple Negative Breast Neoplasms Mutations in exons 19 and 21 of EGFR are commonly found to be associated with no... BeFree 24969895 Detail
0.015 Triple Negative Breast Neoplasms In aggressive, triple-negative, basal-like breast cancers, most tumors display i... BeFree 25073112 Detail
0.015 Triple Negative Breast Neoplasms Abrogating phosphorylation of eIF4B is required for EGFR and mTOR inhibitor syne... BeFree 25129346 Detail
0.015 Triple Negative Breast Neoplasms When TNBCs were divided into basal (cytokeratin 5/6 (CK5/6)+ and/or epidermal gr... BeFree 25179840 Detail
0.015 Triple Negative Breast Neoplasms We used cell line models of EGFR-positive/PTEN null TNBC to elucidate the signal... BeFree 25454348 Detail
0.015 Triple Negative Breast Neoplasms Ad-p53 enhances the sensitivity of triple-negative breast cancer MDA-MB-468 cell... BeFree 25501339 Detail
0.015 Triple Negative Breast Neoplasms The further determination of how the NHERF1‑EGFR interaction is regulated may im... BeFree 25530180 Detail
0.015 Triple Negative Breast Neoplasms The distinct expression of AR and EGFR and the prevalence of BRCA1 mutation indi... BeFree 25695063 Detail
0.015 Triple Negative Breast Neoplasms Triple negative breast cancer (TNBC) is a distinct breast cancer subtype, which ... BeFree 25748387 Detail
0.015 Triple Negative Breast Neoplasms Here, we describe how PEA-15 expression affects the dephosphorylation of epiderm... BeFree 25796184 Detail
0.015 Triple Negative Breast Neoplasms Neurokinin-1 activation affects EGFR related signal transduction in triple negat... BeFree 25817575 Detail
0.015 Triple Negative Breast Neoplasms Signaling via epidermal growth factor receptor (EGFR) and Src kinase pathways pr... BeFree 25823823 Detail
0.015 Triple Negative Breast Neoplasms The expression of p53 was higher in luminal B, HER2-enriched, and triple-negativ... BeFree 25966200 Detail
0.015 Triple Negative Breast Neoplasms EGFR is one of the best-validated driver genes for TNBC. BeFree 26010411 Detail
<0.001 Breast cancer, lobular Strong adverse effect of epidermal growth factor receptor 2 overexpression on pr... BeFree 25804795 Detail
<0.001 Basal-Like Breast Carcinoma NA BeFree Detail
<0.001 Prostatic Cancer, Castration-Resistant NA BeFree Detail
<0.001 Intracranial glioma NA BeFree Detail
0.014 Infection NA LHGDN Detail
0.003 Thymus Neoplasms NA BeFree,LHGDN Detail
0.001 ESTROGEN RESISTANCE NA BeFree Detail
0.002 Experimental Organism Basal Cell Carcinoma NA BeFree Detail
<0.001 Tumors in children NA BeFree Detail
0.120 Inflammatory skin and bowel disease, neonatal, 2 NA UNIPROT Detail
0.008 papillary adenocarcinoma NA BeFree,GAD,LHGDN Detail
0.002 adenoma Inhibition of USP8 or EGFR is promising for treating USP8-mutated corticotrophin... BeFree 25675982 Detail
<0.001 adenosarcoma NA BeFree Detail
<0.001 Adenovirus Infections NA BeFree Detail
<0.001 adrenal gland hyperfunction NA BeFree Detail
<0.001 Alzheimer's disease NA BeFree Detail
<0.001 ameloblastoma NA BeFree Detail
<0.001 amyotrophic lateral sclerosis NA BeFree Detail
0.001 Anaplasia NA BeFree Detail
0.002 Anus Neoplasms NA GAD Detail
<0.001 arteriosclerosis NA BeFree Detail
0.002 rheumatoid arthritis NA BeFree Detail
0.087 asthma Amphiregulin is a member of the family of epidermal growth factor receptor (EGFR... BeFree,GAD,LHGDN,RGD 26047642 Detail
0.024 Astrocytoma These findings provide important information on the mechanisms involved in the p... BeFree,GAD,LHGDN 24170555 Detail
<0.001 atherosclerosis NA BeFree Detail
0.003 Bacterial Infections NA LHGDN Detail
0.003 Barrett esophagus NA LHGDN Detail
0.120 Bile Duct Neoplasms NA CTD_human Detail
0.005 Biliary Tract Neoplasm NA GAD Detail
0.019 Malignant neoplasm of urinary bladder EGFR as a potential therapeutic target for a subset of muscle-invasive bladder c... BeFree,GAD 25009231 Detail
0.019 Malignant neoplasm of urinary bladder Dual regulation of receptor tyrosine kinase genes EGFR and c-Met by the tumor-su... BeFree,GAD 25405368 Detail
0.019 Malignant neoplasm of urinary bladder The epidermal growth factor receptor (EGFR) family is reportedly overexpressed i... BeFree,GAD 25482142 Detail
0.130 Bladder Neoplasm NA BeFree,CTD_human,LHGDN Detail
<0.001 Bone Diseases NA BeFree Detail
<0.001 Bone neoplasms NA BeFree Detail
<0.001 borderline personality disorder NA BeFree Detail
0.024 Brain Neoplasms The mechanisms that drive therapeutic resistance to EGFR inhibitors in brain tum... BeFree,GAD,LHGDN 25103728 Detail
0.024 Brain Neoplasms Here, human brain tumor-initiating cell (BTIC) lines with different combinations... BeFree,GAD,LHGDN 25316808 Detail
0.024 Brain Neoplasms Optical imaging of targeted β-galactosidase in brain tumors to detect EGFR level... BeFree,GAD,LHGDN 25775241 Detail
0.024 Brain Neoplasms The naturally secreted and O-GlcNAcylated MIF binds to EGFR, thereby inhibiting ... BeFree,GAD,LHGDN 26280537 Detail
0.104 Malignant neoplasm of breast A new class of protein cancer biomarker candidates: differentially expressed spl... BeFree,GAD 24802673 Detail
0.104 Malignant neoplasm of breast Complete pharmacologic EGFR/HER2 inhibition is required to reverse Src-dependent... BeFree,GAD 24887236 Detail
0.104 Malignant neoplasm of breast This is a revised case report of a 52 year old Caucasian female with Li-Fraumeni... BeFree,GAD 25047674 Detail
0.104 Malignant neoplasm of breast We suggest that TJE is a new potential reagent for EGFR-targeted therapy and ant... BeFree,GAD 25051266 Detail
0.104 Malignant neoplasm of breast The targeting of the hormone receptor, HER2 and EGFR1 in breast cancer will be r... BeFree,GAD 25051360 Detail
0.104 Malignant neoplasm of breast The epidermal growth factor receptor (EGFR) is a member of the ErbB family that ... BeFree,GAD 25140053 Detail
0.104 Malignant neoplasm of breast Here, we report a proof-of-concept experiment demonstrating that small peptides ... BeFree,GAD 25220456 Detail
0.104 Malignant neoplasm of breast Our results showed that CD44 expression was significantly increased by epidermal... BeFree,GAD 25269647 Detail
0.104 Malignant neoplasm of breast Prognostic and predictive values of EGFR overexpression and EGFR copy number alt... BeFree,GAD 25349977 Detail
0.104 Malignant neoplasm of breast In both the primary cancers and the metastases, Claudin-4 was most frequently ex... BeFree,GAD 25417118 Detail
0.104 Malignant neoplasm of breast BRCA1 regulation of epidermal growth factor receptor (EGFR) expression in human ... BeFree,GAD 25417703 Detail
0.104 Malignant neoplasm of breast Because mutations within HER1/EGFR are predictive of response to tyrosine kinase... BeFree,GAD 25435280 Detail
0.104 Malignant neoplasm of breast Oncogenic signaling in amphiregulin and EGFR-expressing PTEN-null human breast c... BeFree,GAD 25454348 Detail
0.104 Malignant neoplasm of breast Coexpression of EGFR and HER2 has been associated with poor disease outcome, hig... BeFree,GAD 25510900 Detail
0.104 Malignant neoplasm of breast While ERBB1, ERBB2 and ERBB3 are often overexpressed or activated in breast canc... BeFree,GAD 25516216 Detail
0.104 Malignant neoplasm of breast We propose that miR-7 regulated pathways, including EGFR and Src kinase, represe... BeFree,GAD 25532106 Detail
0.104 Malignant neoplasm of breast Estrogen-responsive genes most significantly influenced by cohesin were enriched... BeFree,GAD 25542856 Detail
0.104 Malignant neoplasm of breast This study identifies mutant p53 as an essential player in ErbB2 and EGFR-mediat... BeFree,GAD 25573952 Detail
0.104 Malignant neoplasm of breast TXNIP interaction with the Her-1/2 pathway contributes to overall survival in br... BeFree,GAD 25605021 Detail
0.104 Malignant neoplasm of breast Lapatinib, a dual tyrosine kinase inhibitor that interrupts the epidermal growth... BeFree,GAD 25605188 Detail
0.104 Malignant neoplasm of breast Amplified HER2, which encodes a member of the epidermal growth factor receptor (... BeFree,GAD 25605973 Detail
0.104 Malignant neoplasm of breast Further understanding of the paradoxical function of EGFR between primary and me... BeFree,GAD 25622905 Detail
0.104 Malignant neoplasm of breast Loss of catalytically functional PTPN14 increased the secretion of growth factor... BeFree,GAD 25690013 Detail
0.104 Malignant neoplasm of breast More and more evidences demonstrate that androgen receptor (AR), epidermal growt... BeFree,GAD 25695063 Detail
0.104 Malignant neoplasm of breast Epidermal growth factor receptor and AKT1 gene copy numbers by multi-gene fluore... BeFree,GAD 25702787 Detail
0.104 Malignant neoplasm of breast A benzimidazole derivative exhibiting antitumor activity blocks EGFR and HER2 ac... BeFree,GAD 25766325 Detail
0.104 Malignant neoplasm of breast To identify a prognostic signature for breast cancer, we performed DNA methylati... BeFree,GAD 25773928 Detail
0.104 Malignant neoplasm of breast Kindlin-2 interacts with and stabilizes EGFR and is required for EGF-induced bre... BeFree,GAD 25790908 Detail
0.104 Malignant neoplasm of breast Upregulation of HER3 has been found to be a major mechanism underlying drug resi... BeFree,GAD 25849870 Detail
0.104 Malignant neoplasm of breast Endocrine therapy considerations in postmenopausal patients with hormone recepto... BeFree,GAD 25857348 Detail
0.104 Malignant neoplasm of breast Correlation between p53 and epidermal growth factor receptor expression in breas... BeFree,GAD 25966200 Detail
0.104 Malignant neoplasm of breast Using the MCF10A/MCF10CA1a Breast Cancer Progression Cell Line Model to Investig... BeFree,GAD 25969993 Detail
0.104 Malignant neoplasm of breast Requirement of ERα and basal activities of EGFR and Src kinase in Cd-induced act... BeFree,GAD 26006730 Detail
0.104 Malignant neoplasm of breast The majority of breast cancers present with estrogen receptor (ER)-positive and ... BeFree,GAD 26059247 Detail
0.104 Malignant neoplasm of breast Thirty-two locally/systemically advanced breast cancers treated with first-line ... BeFree,GAD 26178788 Detail
0.003 Breast Diseases NA LHGDN Detail
<0.001 bronchitis NA BeFree Detail
<0.001 bronchopulmonary dysplasia NA BeFree Detail
<0.001 Cachexia NA BeFree Detail
0.004 Carcinoid Tumor NA BeFree,LHGDN Detail
0.023 Malignant tumor of colon Here we show a clear correlation between the efficacy of anti-EGFR inhibitors wi... BeFree 24556630 Detail
0.023 Malignant tumor of colon These results indicate that ERBB3 is a potential target for EGFR- and ERBB2-resi... BeFree 24970817 Detail
0.023 Malignant tumor of colon Importantly, hyperactivation of SRC/EGFR signaling triggered by loss of PTPRO le... BeFree 25301722 Detail
0.023 Malignant tumor of colon EZH2 inhibition enhances the efficacy of an EGFR inhibitor in suppressing colon ... BeFree 25535899 Detail
0.023 Malignant tumor of colon KRAS mutations also induce anti-EGFR antibody resistance in adenocarcinoma such ... BeFree 25589625 Detail
0.023 Malignant tumor of colon Mutations at the K-RAS locus in colon cancer cells are frequently associated wit... BeFree 25675084 Detail
0.023 Malignant tumor of colon In contrast, forced expression of MITF in melanoma and colon cancer cells inhibi... BeFree 25789707 Detail
0.004 Malignant neoplasm of endometrium These new findings about endometrial cancer suggest a potential for targeted the... BeFree 24820961 Detail
0.002 Malignant neoplasm of larynx Higher expression of the EGFR cascade in cannabis smokers revealed that cannabis... BeFree 25736926 Detail
<0.001 Adenocarcinoma of prostate Molecular Characterization of KRAS, BRAF, and EGFR Genes in Cases with Prostatic... BeFree 26299074 Detail
0.006 Rectal Carcinoma EGFR ligands and DNA repair genes: genomic predictors of complete response after... BeFree,GAD 25026457 Detail
<0.001 Malignant neoplasm of skin NA BeFree Detail
0.003 Malignant neoplasm of thyroid NA BeFree Detail
0.003 basal cell carcinoma NA LHGDN Detail
0.027 Bronchioloalveolar Adenocarcinoma We assume that the LCNEC originated from the adenocarcinoma based on the fact th... BeFree,GAD,LHGDN 23518631 Detail
0.027 Bronchioloalveolar Adenocarcinoma A significantly higher incidence of EGFR mutations was observed in bronchioloalv... BeFree,GAD,LHGDN 25684509 Detail
<0.001 Bronchogenic Carcinoma NA BeFree Detail
0.008 Noninfiltrating Intraductal Carcinoma NA BeFree,LHGDN Detail
<0.001 Merkel cell carcinoma NA BeFree Detail
0.005 mucinous adenocarcinoma A single-institute cohort study in Taiwan was performed to determine the mutatio... BeFree,GAD 24913807 Detail
0.005 mucinous adenocarcinoma The clinicopathological significance of ALK rearrangements and KRAS and EGFR mut... BeFree,GAD 25813151 Detail
0.005 mucinous adenocarcinoma The aim of this study was to compare colorectal adenocarcinoma with mucinous com... BeFree,GAD 25907382 Detail
0.002 Carcinoma, Papillary NA GAD Detail
0.016 renal cell carcinoma NA BeFree,GAD,LHGDN Detail
Annotation

Annotations

DescrptionSourceLinks
A phase 2 study of 120 stage IIIB-IV lung adenocarcinoma patients reported improved progression free... CIViC Evidence Detail
The phase 3 (EURTAC) study consisted of of 173 non-small cell lung cancer patients who had not had p... CIViC Evidence Detail
In a study of 1261 non-small cell lung cancer patients, 49.8% of the analyzed tumors had EGFR mutati... CIViC Evidence Detail
In a cohort of NSCLC patients treated with tyrosine kinase inhibitors erlotinib or gefitinib, 61 pat... CIViC Evidence Detail
In a study of 1261 non-small cell lung cancer patients, 49.8% of the analyzed tumors had EGFR mutati... CIViC Evidence Detail
In a cohort of NSCLC patients tested for mutation in EGFR exons 18-21 a subset had uncommon mutation... CIViC Evidence Detail
In a study of 19 non-small cell lung carcinoma patients with EGFR exon 20 insertion mutation and tre... CIViC Evidence Detail
In a non-small cell lung cancer patient harboring EGFR P772_H773insYNP mutation, EGFR P772_H773insYN... CIViC Evidence Detail
In a lung adenocarcinoma patient harboring EGFR P772_V774insPHV mutation, EGFR P772_V774insPHV was a... CIViC Evidence Detail
Detection of mutation-specific epidermal growth factor receptor (E746-A750del) and lack of detection... DisGeNET Detail
Lack of mutations in protein tyrosine kinase domain coding exons 19 and 21 of the EGFR gene in oral ... DisGeNET Detail
Over-expression of epidermal growth factor receptor (EGFR) has been identified as a common feature a... DisGeNET Detail
Our results suggest that EGFR expression in squamous cell carcinoma is different with regard to tumo... DisGeNET Detail
Acquired resistance to EGFR tyrosine kinase inhibitor in A431 squamous cell carcinoma xenografts is ... DisGeNET Detail
Our data show that the overall frequency of EGFR gene mutations in lung adenocarcinomas in the East ... DisGeNET Detail
The occurrence of EGFR mutations in pulmonary SQCC might be overestimated. DisGeNET Detail
Shikonin causes cell-cycle arrest and induces apoptosis by regulating the EGFR-NF-κB signalling path... DisGeNET Detail
Epidermal growth factor receptor inhibition reduces angiogenesis via hypoxia-inducible factor-1α and... DisGeNET Detail
High-Frequency Targetable EGFR Mutations in Sinonasal Squamous Cell Carcinomas Arising from Inverted... DisGeNET Detail
This study details the empirical basis for a feasible clinical solution for squamous cell carcinomas... DisGeNET Detail
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Studies in cervical cancer indicate that E5 increases epidermal growth factor receptor (EGFR) recycl... DisGeNET Detail
FTS is responsible for radiation-induced nuclear phosphorylation of EGFR and repair of DNA damage in... DisGeNET Detail
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We find that miR-34a inversely correlates with MET expression and miR-608 inversely correlates with ... DisGeNET Detail
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Three different macroscopic subtypes of colorectal neoplasms display distinct carcinogenetic pathway... DisGeNET Detail
We exploited circulating tumor DNA (ctDNA) to genotype colorectal tumors and track clonal evolution ... DisGeNET Detail
We validated COLD-ddPCR on multiple mutations in TP53 and in EGFR using serial mutation dilutions an... DisGeNET Detail
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Taken together, this study defines the genomic landscape underlying phyllodes tumor development, sug... DisGeNET Detail
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Staphylococcus aureus skin colonization is universal in atopic dermatitis and common in cancer patie... DisGeNET Detail
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The 13 patients with DM were more likely to express IGF-1R (p=0.001) and had shorter PFS times when ... DisGeNET Detail
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In addition, EGFR wild type receptor inhibition inherent with these agents can lead to dose limiting... DisGeNET Detail
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IL-6, IL-9, CCL24, CCL18, IL-10, IFN-γ, and CCL2 were highly increased (>6-fold); 26 genes were mode... DisGeNET Detail
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Staphylococcus aureus skin colonization is universal in atopic dermatitis and common in cancer patie... DisGeNET Detail
Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have shown improved progre... DisGeNET Detail
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We show for the first time a significant treatment response to the EGFR tyrosine kinase inhibitor ge... DisGeNET Detail
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IL-6, IL-9, CCL24, CCL18, IL-10, IFN-γ, and CCL2 were highly increased (>6-fold); 26 genes were mode... DisGeNET Detail
Epidermal growth factor receptor (EGFR), HER2 and insulin-like growth factor-1 receptor (IGF-1R) sta... DisGeNET Detail
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Interferon-α inducible protein 6 impairs EGFR activation by CD81 and inhibits hepatitis C virus infe... DisGeNET Detail
Hepatitis C virus NS5A protein blocks epidermal growth factor receptor degradation via a proline mot... DisGeNET Detail
Impact of epidermal growth factor receptor and transforming growth factor-α on hepatitis C virus-ind... DisGeNET Detail
To address the concern that this safety feature may reduce oncolytic activity, we inserted the miR-1... DisGeNET Detail
A multi-institutional study of clinicopathological features and molecular epidemiology of epidermal ... DisGeNET Detail
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Diagnostic values of vascular endothelial growth factor and epidermal growth factor receptor for ben... DisGeNET Detail
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A common germline deletion in the BIM gene was recently shown to favor the production of non-apoptot... DisGeNET Detail
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By immunohistochemistry EGFR and TGF-α were overexpressed in HCC and cirrhotic cases compared to CHC... DisGeNET Detail
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MiR-133a expression was negatively correlated to lymphatic metastasis (r = -0.182, P = 0.042), tumor... DisGeNET Detail
The initial set of trials will focus on different questions: (1) Exceptional Responders Initiative-w... DisGeNET Detail
Consistent with previous studies demonstrating a role for muscarinic and epidermal growth factor rec... DisGeNET Detail
The present study was to determine the role of KRAS status in EGFR antibody treatment for gastric ca... DisGeNET Detail
Many molecular pathways are currently under investigation as therapeutic targets in gastric cancer, ... DisGeNET Detail
These results support the involvement of EGFR and HER2 in gastric cancer and suggest an interesting ... DisGeNET Detail
Inhibition of epidermal growth factor receptor signaling prohibits metastasis of gastric cancer via ... DisGeNET Detail
Identification of EGFR expression status association with metastatic lymph node density (ND) by expr... DisGeNET Detail
Patients with HER2(+) /EGFR(+) /MET(+) GCs had a substantial risk of death with a hazard ratio of 3.... DisGeNET Detail
Knockdown of EGFR inhibits growth and invasion of gastric cancer cells. DisGeNET Detail
Gastric cancer in young vs old Romanian patients: immunoprofile with emphasis on maspin and mena pro... DisGeNET Detail
The prevalence of genomic copy number aberrations of epidermal growth factor receptor (EGFR), human ... DisGeNET Detail
In addition, synergy in growth inhibition was observed when the GC cells were treated with a combina... DisGeNET Detail
The results demonstrated that EGFR phosphorylation was markedly inhibited in gastric cancer cell lin... DisGeNET Detail
Cetuximab, an immunoglobulin G1 chimeric monoclonal antibody directed against the epidermal growth f... DisGeNET Detail
EGFR gene polymorphisms -216G>T and -191C>A are risk markers for gastric cancer in Mexican populatio... DisGeNET Detail
In gastric cancer (GC), epidermal growth factor receptor (EGFR) overexpression associates with poor ... DisGeNET Detail
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Higher expression of the EGFR cascade in cannabis smokers revealed that cannabis smoking may be a ma... DisGeNET Detail
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Overexpression of EGFR predicts poor outcomes of MBs, small cell GBMs and PNETs, suggesting those th... DisGeNET Detail
Epigenetic changes of EGFR have an important role in BRAF inhibitor-resistant cutaneous melanomas. DisGeNET Detail
An inverse relationship between MITF, vemurafenib resistance, and EGFR was then observed in patient ... DisGeNET Detail
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Regarding that also EGFR amplifications in MPM are absolute rarities, our findings may be a hint tha... DisGeNET Detail
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Multiple myeloma acquires resistance to EGFR inhibitor via induction of pentose phosphate pathway. DisGeNET Detail
The germline polymorphisms studied were thymidylate synthase, (VNTR/5'UTR, 2R G&gt;C single nucleoti... DisGeNET Detail
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Association of PTPN22 rs2476601 and EGFR rs17337023 Gene polymorphisms and rheumatoid arthritis in Z... DisGeNET Detail
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Using the Snapshot assay, mutation statuses were detected for EGFR, Kirsten rate sarcoma viral oncog... DisGeNET Detail
Clinically, EGFR inhibitors are ineffective as single agent compounds in patients with recurrent NB,... DisGeNET Detail
Transgenic mice heterozygous for a Trp53-null allele and overexpressing EGFR in Schwann cells had a ... DisGeNET Detail
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For overall patients, EGFR mutation status was associated with gender, pStage, pT status, lepidic do... DisGeNET Detail
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Thus, miR-143, EGFR, and MMP9 are therapeutic targets for inhibiting OS invasion. DisGeNET Detail
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Yes-associated protein (YAP) has been reported to be associated with the prognosis of various cancer... DisGeNET Detail
The crosstalk between PAFR and EGFR suggests a potentially important signaling linkage between infla... DisGeNET Detail
miR-491-5p-induced apoptosis in ovarian carcinoma depends on the direct inhibition of both BCL-XL an... DisGeNET Detail
We found that ErbB-1 was localized predominantly in the nucleus of ovarian cancer cells examined, co... DisGeNET Detail
Of the two postulated miR-7 target genes we examined, BCL2, but not EGFR, seems to be a possible miR... DisGeNET Detail
Both epidermal growth factor receptor (EGFR) and fibroblast growth factor receptor 1 (FGFR1) are ove... DisGeNET Detail
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EGFR mutations were not identified in exophytic or oncocytic papillomas or non-ISP-associated SNSCC,... DisGeNET Detail
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It is feasible to detect the gene copy number of the pleural effusion cell mass EGFR by FISH techniq... DisGeNET Detail
The results established the important role of HRM as a reliable and efficient method to determine EG... DisGeNET Detail
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ErbB receptor-driven prolactinomas respond to targeted lapatinib treatment in female transgenic mice... DisGeNET Detail
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Analysis of tumour samples and cell lines derived from resistant EGFR mutant patients revealed that ... DisGeNET Detail
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However, the results of phase II trials of EGFR inhibitors-as well as other targeted agents--in sali... DisGeNET Detail
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Does gefitinib have effects on EGFR mutation-positive thymoma? -Case report of thymoma recurrence. DisGeNET Detail
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Gender-based impact of epidermal growth factor receptor mutation in patients with nonsmall cell lung... DisGeNET Detail
Comparing to male with pulmonary TB history, female with or without pulmonary TB history and male wi... DisGeNET Detail
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Some miR-7 targets, including B-cell lymphoma 2 (BCL2) and epidermal growth factor receptor (EGFR), ... DisGeNET Detail
Frequency of EGFR mutations in lung adenocarcinoma with malignant pleural effusion: Implication of c... DisGeNET Detail
Sea-urchin-like Au nanocluster with surface-enhanced raman scattering in detecting epidermal growth ... DisGeNET Detail
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EGFR-mutated lung cancer in Li-Fraumeni syndrome. DisGeNET Detail
We report two cases of non-smoker patients diagnosed with EGFR-mutated lung adenocarcinoma and beari... DisGeNET Detail
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Finally, an inverse correlation was observed between Fhit and phospho-EGFR levels in a cohort of hum... DisGeNET Detail
The initial set of trials will focus on different questions: (1) Exceptional Responders Initiative-w... DisGeNET Detail
Tumor-suppressive microRNA-206 as a dual inhibitor of MET and EGFR oncogenic signaling in lung squam... DisGeNET Detail
We examined EGFR mutations in exons 19 and 21 in 147 NSCLC patients (excluding squamous cell lung ca... DisGeNET Detail
Cell membrane CD44v6 levels in squamous cell carcinoma of the lung: association with high cellular p... DisGeNET Detail
Epidermal growth factor receptor gene mutation status in pure squamous-cell lung cancer in Chinese p... DisGeNET Detail
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Epigenetic changes of EGFR have an important role in BRAF inhibitor-resistant cutaneous melanomas. DisGeNET Detail
Esophageal carcinoma cell line with high EGFR polysomy is responsive to gefitinib. DisGeNET Detail
Inhibition of EGFR in pre-clinical models of oral pre-malignancies validates this approach as an eff... DisGeNET Detail
Targeting Ley on EGFR could have a potential therapeutic effect on oral cancer. DisGeNET Detail
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Anecdotal benefit from EGFR-targeted therapy has been reported in anal cancer and a negative correla... DisGeNET Detail
In conclusion, the present study indicated that the mechanism of action of miR-146b-5p in GBC involv... DisGeNET Detail
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In this study, we analyzed the expression of MAGE-A, a cancer-testis antigen, in tumors from a cohor... DisGeNET Detail
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In multivariate analysis, lobulated margins (odds ratio, 4.815; 95% confidence interval [CI]: 1.789,... DisGeNET Detail
Our findings support a model in which nuclear EGFR acts as a transcriptional repressor to constrain ... DisGeNET Detail
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Aberrant epidermal growth factor receptor (EGFR) signaling in non-small cell lung cancer (NSCLC) is ... DisGeNET Detail
ERBB2/HER2 belongs to the EGFR-family of receptor tyrosine kinases and its overexpression can promot... DisGeNET Detail
One mechanism by which EGFR promotes tumor progression is by activating signal cascades that lead to... DisGeNET Detail
Epidermal growth factor receptor (EGFR) mutation is one of the hallmarks of cancer progression and r... DisGeNET Detail
Activation of epidermal growth factor receptor (EGFR), which occurs in many types of tumour, promote... DisGeNET Detail
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Epidermal growth factor receptor (EGFR) pathway genes and interstitial lung disease: an association ... DisGeNET Detail
The frequency of interstitial lung disease (ILD) of grade ≥3 was low (0.6-2.2%) with all three EGFR-... DisGeNET Detail
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Overexpression of EGFR predicts poor outcomes of MBs, small cell GBMs and PNETs, suggesting those th... DisGeNET Detail
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We identified 126 EGFR-mutated (21.8% of 578 successful genotyped cases) lung cancers and only 2 (1.... DisGeNET Detail
In this review article, we discuss the molecular aspects of CCA including the role of erbB receptor ... DisGeNET Detail
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A significantly higher incidence of EGFR mutations was observed in bronchioloalveolar carcinomas (28... DisGeNET Detail
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Transgenic mice heterozygous for a Trp53-null allele and overexpressing EGFR in Schwann cells had a ... DisGeNET Detail
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Inhibition of EGFR in pre-clinical models of oral pre-malignancies validates this approach as an eff... DisGeNET Detail
Targeting Ley on EGFR could have a potential therapeutic effect on oral cancer. DisGeNET Detail
Our case suggests that dual targeting of epidermal growth factor receptor (EGFR) by a combination of... DisGeNET Detail
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It represents a potential therapeutic option against LM after failure of standard-dose EGFR-TKIs, es... DisGeNET Detail
ALK positive lung adenocarcinomas are more likely than EGFR mutant lung adenocarcinomas to be associ... DisGeNET Detail
In conclusion, the present study indicated that the mechanism of action of miR-146b-5p in GBC involv... DisGeNET Detail
EGFR has been implicated in various malignancies such as NSCLC, breast, head and neck, and pancreati... DisGeNET Detail
Together, these studies provide further support for a role for EGFR and HER2 in pancreatic cancer pr... DisGeNET Detail
Lumican plays a restrictive role in EGFR-expressing pancreatic cancer progression. DisGeNET Detail
Low expression of the E3 ubiquitin ligase CBL confers chemoresistance in human pancreatic cancer and... DisGeNET Detail
In conclusion, our studies will enhance the translational acquaintance of pan-EGFR inhibitors for co... DisGeNET Detail
Moreover, EGFR was found to mediate the REG3A signal for PaC cell growth and JAK2/STAT3 activation, ... DisGeNET Detail
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Targeting c-Kit plus HER1 or AXL/c-Met abrogates IM resistance in GIST. DisGeNET Detail
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Localisation of PTPD1 at the plasma membrane was mediated by its FERM domain and enabled the formati... DisGeNET Detail
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In conclusion, miR-214 appears to participate in the development of hepatic fibrosis by modulating t... DisGeNET Detail
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Epidermal growth factor receptor overexpression is a predictive factor for trastuzumab response in H... DisGeNET Detail
Resistance to the human epidermal growth factor receptor (HER2)-targeted antibody trastuzumab is a m... DisGeNET Detail
The antitumorigenic function of EGFR in metastatic breast cancer is regulated by expression of Mig6. DisGeNET Detail
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To determine the frequency and clinical significance of epidermal growth factor receptor (EGFR) muta... DisGeNET Detail
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Chromosome 7 polysomy may be responsible for EGFR gene amplifications, and we concluded that MET and... DisGeNET Detail
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Thus, we suggest that Musashi-1, Lgr5, and pEGFR are overexpressed in human SIAs and may play roles ... DisGeNET Detail
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A randomised, open label phase III trial with nimotuzumab, an anti-epidermal growth factor receptor ... DisGeNET Detail
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An inverse relationship between MITF, vemurafenib resistance, and EGFR was then observed in patient ... DisGeNET Detail
Targeting the epidermal growth factor receptor for head and neck cancer chemoprevention. DisGeNET Detail
Better anti-EGFR treatment efficacy was related to lower EGFR expression in head and neck cancer cel... DisGeNET Detail
Inhibition of EGFR or IGF-1R signaling enhances radiation response in head and neck cancer models bu... DisGeNET Detail
Effective therapeutic approach for head and neck cancer by an engineered minibody targeting the EGFR... DisGeNET Detail
MyD88-Dependent Signaling Decreases the Antitumor Efficacy of Epidermal Growth Factor Receptor Inhib... DisGeNET Detail
The EGFR-targeted antibody cetuximab is effective against head and neck cancer (HNSCC), but in only ... DisGeNET Detail
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EGFR gene mutations in patients with adenosquamous lung carcinoma. DisGeNET Detail
We show for the first time a significant treatment response to the EGFR tyrosine kinase inhibitor ge... DisGeNET Detail
Epidermal growth factor receptor (EGFR) is an independent adverse prognostic factor in esophageal ad... DisGeNET Detail
Anecdotal benefit from EGFR-targeted therapy has been reported in anal cancer and a negative correla... DisGeNET Detail
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Overexpression of EGFR predicts poor outcomes of MBs, small cell GBMs and PNETs, suggesting those th... DisGeNET Detail
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The initial set of trials will focus on different questions: (1) Exceptional Responders Initiative-w... DisGeNET Detail
Preclinical studies have shown synergism between epidermal growth factor receptor (EGFR) tyrosine ki... DisGeNET Detail
Cetuximab (anti-epidermal growth factor receptor - EGFR - monoclonal antibody) is a promising target... DisGeNET Detail
Ubiquitous overexpression of wild type EGFR in many solid tumors has led to the development of EGFR ... DisGeNET Detail
Eligible patients were aged at least 18 years with histologically confirmed, chemotherapy-naive, sta... DisGeNET Detail
Molecular testing for epidermal growth factor receptor (EGFR) mutations is required to select the mo... DisGeNET Detail
Although surgical resection remains standard treatment for early stage non-small-cell lung cancer (N... DisGeNET Detail
Epidermal growth factor receptor tyrosine kinase inhibitors in early-stage nonsmall cell lung cancer... DisGeNET Detail
Statins augment efficacy of EGFR-TKIs in patients with advanced-stage non-small cell lung cancer har... DisGeNET Detail
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Biopsy specimens of patients with glottic squamous cell carcinoma and simple hyperplasia (control sa... DisGeNET Detail
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Studies in cervical cancer indicate that E5 increases epidermal growth factor receptor (EGFR) recycl... DisGeNET Detail
FTS is responsible for radiation-induced nuclear phosphorylation of EGFR and repair of DNA damage in... DisGeNET Detail
IL-6, IL-9, CCL24, CCL18, IL-10, IFN-γ, and CCL2 were highly increased (>6-fold); 26 genes were mode... DisGeNET Detail
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High-Frequency Targetable EGFR Mutations in Sinonasal Squamous Cell Carcinomas Arising from Inverted... DisGeNET Detail
Adenocarcinoma in situ showed significantly higher DPD mRNA levels and more EGFR mutation frequency ... DisGeNET Detail
The remaining 26 quadruple-negative tumors were significantly associated with AAH/AIS (P < 0.01) and... DisGeNET Detail
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FLC overexpresses EGFR in comparison to hepatocellular cancer, suggesting that EGFR targeting may be... DisGeNET Detail
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EGFR has been implicated in various malignancies such as NSCLC, breast, head and neck, and pancreati... DisGeNET Detail
Together, these studies provide further support for a role for EGFR and HER2 in pancreatic cancer pr... DisGeNET Detail
Lumican plays a restrictive role in EGFR-expressing pancreatic cancer progression. DisGeNET Detail
Low expression of the E3 ubiquitin ligase CBL confers chemoresistance in human pancreatic cancer and... DisGeNET Detail
In conclusion, our studies will enhance the translational acquaintance of pan-EGFR inhibitors for co... DisGeNET Detail
Moreover, EGFR was found to mediate the REG3A signal for PaC cell growth and JAK2/STAT3 activation, ... DisGeNET Detail
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Female gender, tumor size, lymphovascular invasion and EGFR overexpression were predictive risk fact... DisGeNET Detail
These results suggested that ADAM10 is important in regulating the proliferation, invasion and migra... DisGeNET Detail
Helicobacter pylori transactivates the epidermal growth factor receptor (EGFR) on gastric epithelial... DisGeNET Detail
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Recently, ETS-related gene (ERG) gene rearrangements, phosphatase tensin homologue (PTEN) deletions ... DisGeNET Detail
EGFR mediates docetaxel resistance in human castration-resistant prostate cancer through the Akt-dep... DisGeNET Detail
Human epidermal growth factor receptor family members (HER) such as EGFR and HER2 are involved in mi... DisGeNET Detail
We propose that the loss of miR-203 is a molecular link in the progression of prostate cancer metast... DisGeNET Detail
Among these modules, transcription Androgen Receptor (AR) nuclear signaling and Epidermal Growth Fac... DisGeNET Detail
Berberine targets epidermal growth factor receptor signaling to suppress prostate cancer proliferati... DisGeNET Detail
In this manuscript, we will discuss an inducible EGFR model (v-ERB-B:ER) and its effects on cell gro... DisGeNET Detail
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Evidence for different expression profiles for c-Met, EGFR, PTEN and the mTOR pathway in low and hig... DisGeNET Detail
These new findings about endometrial cancer suggest a potential for targeted therapy with lapatinib,... DisGeNET Detail
A 33-year-old pregnant mother exhibited a disseminated EGFR-mutated lung carcinoma with respiratory ... DisGeNET Detail
Patients with an EGFR mutation were more prone to having synchronous LM than patients with EGFR wild... DisGeNET Detail
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Because STAT signaling is commonly activated in malignant gliomas as a result of constitutive EGFR a... DisGeNET Detail
Development of Resistance to EGFR-Targeted Therapy in Malignant Glioma Can Occur through EGFR-Depend... DisGeNET Detail
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Additionally, cholangiocytes from LPS-treated mouse livers and human primary sclerosing cholangitis ... DisGeNET Detail
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Thus, miR-143, EGFR, and MMP9 are therapeutic targets for inhibiting OS invasion. DisGeNET Detail
Higher expression of the EGFR cascade in cannabis smokers revealed that cannabis smoking may be a ma... DisGeNET Detail
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Recently, ETS-related gene (ERG) gene rearrangements, phosphatase tensin homologue (PTEN) deletions ... DisGeNET Detail
EGFR mediates docetaxel resistance in human castration-resistant prostate cancer through the Akt-dep... DisGeNET Detail
Human epidermal growth factor receptor family members (HER) such as EGFR and HER2 are involved in mi... DisGeNET Detail
We propose that the loss of miR-203 is a molecular link in the progression of prostate cancer metast... DisGeNET Detail
Among these modules, transcription Androgen Receptor (AR) nuclear signaling and Epidermal Growth Fac... DisGeNET Detail
Berberine targets epidermal growth factor receptor signaling to suppress prostate cancer proliferati... DisGeNET Detail
In this manuscript, we will discuss an inducible EGFR model (v-ERB-B:ER) and its effects on cell gro... DisGeNET Detail
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miR-491-5p-induced apoptosis in ovarian carcinoma depends on the direct inhibition of both BCL-XL an... DisGeNET Detail
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Despite the efficacy and superiority of EGFR TKIs over chemotherapy as first-line therapy, all patie... DisGeNET Detail
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Although KRAS mutation has a predictive role in stage IV colorectal cancer (CRC) patients treated wi... DisGeNET Detail
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A new class of protein cancer biomarker candidates: differentially expressed splice variants of ERBB... DisGeNET Detail
Complete pharmacologic EGFR/HER2 inhibition is required to reverse Src-dependent resistance to lapat... DisGeNET Detail
This is a revised case report of a 52 year old Caucasian female with Li-Fraumeni syndrome with a rar... DisGeNET Detail
We suggest that TJE is a new potential reagent for EGFR-targeted therapy and anti-abnormal metastasi... DisGeNET Detail
The targeting of the hormone receptor, HER2 and EGFR1 in breast cancer will be reviewed in associati... DisGeNET Detail
The epidermal growth factor receptor (EGFR) is a member of the ErbB family that can promote the migr... DisGeNET Detail
Here, we report a proof-of-concept experiment demonstrating that small peptides interfering with the... DisGeNET Detail
Our results showed that CD44 expression was significantly increased by epidermal growth factor recep... DisGeNET Detail
Prognostic and predictive values of EGFR overexpression and EGFR copy number alteration in HER2-posi... DisGeNET Detail
In both the primary cancers and the metastases, Claudin-4 was most frequently expressed, followed by... DisGeNET Detail
BRCA1 regulation of epidermal growth factor receptor (EGFR) expression in human breast cancer cells ... DisGeNET Detail
Because mutations within HER1/EGFR are predictive of response to tyrosine kinase inhibitors (TKI) in... DisGeNET Detail
Oncogenic signaling in amphiregulin and EGFR-expressing PTEN-null human breast cancer. DisGeNET Detail
Coexpression of EGFR and HER2 has been associated with poor disease outcome, high rates of metastasi... DisGeNET Detail
While ERBB1, ERBB2 and ERBB3 are often overexpressed or activated in breast cancer, and are oncogeni... DisGeNET Detail
We propose that miR-7 regulated pathways, including EGFR and Src kinase, represent targets for the t... DisGeNET Detail
Estrogen-responsive genes most significantly influenced by cohesin were enriched in pathways associa... DisGeNET Detail
This study identifies mutant p53 as an essential player in ErbB2 and EGFR-mediated mammary tumorigen... DisGeNET Detail
TXNIP interaction with the Her-1/2 pathway contributes to overall survival in breast cancer. DisGeNET Detail
Lapatinib, a dual tyrosine kinase inhibitor that interrupts the epidermal growth factor receptor (EG... DisGeNET Detail
Amplified HER2, which encodes a member of the epidermal growth factor receptor (EGFR) family, is a t... DisGeNET Detail
Further understanding of the paradoxical function of EGFR between primary and metastatic tumors will... DisGeNET Detail
Loss of catalytically functional PTPN14 increased the secretion of growth factors and cytokines, suc... DisGeNET Detail
More and more evidences demonstrate that androgen receptor (AR), epidermal growth factor receptor (E... DisGeNET Detail
Epidermal growth factor receptor and AKT1 gene copy numbers by multi-gene fluorescence in situ hybri... DisGeNET Detail
A benzimidazole derivative exhibiting antitumor activity blocks EGFR and HER2 activity and upregulat... DisGeNET Detail
To identify a prognostic signature for breast cancer, we performed DNA methylation profiling and ide... DisGeNET Detail
Kindlin-2 interacts with and stabilizes EGFR and is required for EGF-induced breast cancer cell migr... DisGeNET Detail
Upregulation of HER3 has been found to be a major mechanism underlying drug resistance to EGFR and H... DisGeNET Detail
Endocrine therapy considerations in postmenopausal patients with hormone receptor positive, human ep... DisGeNET Detail
Correlation between p53 and epidermal growth factor receptor expression in breast cancer classificat... DisGeNET Detail
Using the MCF10A/MCF10CA1a Breast Cancer Progression Cell Line Model to Investigate the Effect of Ac... DisGeNET Detail
Requirement of ERα and basal activities of EGFR and Src kinase in Cd-induced activation of MAPK/ERK ... DisGeNET Detail
The majority of breast cancers present with estrogen receptor (ER)-positive and human epidermal grow... DisGeNET Detail
Thirty-two locally/systemically advanced breast cancers treated with first-line fulvestrant (250 mg/... DisGeNET Detail
Overexpression of EGFR predicts poor outcomes of MBs, small cell GBMs and PNETs, suggesting those th... DisGeNET Detail
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Afatinib may therefore be an effective treatment for heavily pretreated patients with EGFR-mutated o... DisGeNET Detail
Moreover, the expression of miR-183-3p in tumor tissue was found to be associated with lymph node me... DisGeNET Detail
The overall analysis showed that higher expression of ALDH1A1 is associated with larger tumor size, ... DisGeNET Detail
Upregulation of EGFR expression is associated with lymph node metastases of GC, and blockade of EGFR... DisGeNET Detail
Female gender, tumor size, lymphovascular invasion and EGFR overexpression were predictive risk fact... DisGeNET Detail
Both Univariate (U) and COX multivariate (C) analyses revealed that high EGFR and AKT1 gene copy num... DisGeNET Detail
The COX-2(+)/EGFR(+) group was associated with tumor size (p=0.002), mitotic index (p=0.019), histol... DisGeNET Detail
TNBC had a lower lymph node metastasis rate but higher CK5/6 and EGFR expression than the other thre... DisGeNET Detail
Here we show a clear correlation between the efficacy of anti-EGFR inhibitors with their ability to ... DisGeNET Detail
These results indicate that ERBB3 is a potential target for EGFR- and ERBB2-resistant colon cancer t... DisGeNET Detail
Importantly, hyperactivation of SRC/EGFR signaling triggered by loss of PTPRO leads to high resistan... DisGeNET Detail
To elucidate the role of HMGA1 proteins in chemoresistance we analyzed resistance to conventional dr... DisGeNET Detail
EZH2 inhibition enhances the efficacy of an EGFR inhibitor in suppressing colon cancer cells. DisGeNET Detail
KRAS mutations also induce anti-EGFR antibody resistance in adenocarcinoma such as colon cancer. DisGeNET Detail
Mutations at the K-RAS locus in colon cancer cells are frequently associated with lack of responsive... DisGeNET Detail
In contrast, forced expression of MITF in melanoma and colon cancer cells inhibited EGFR and conferr... DisGeNET Detail
Treatment of metastatic colon carcinoma with the anti-epidermal growth factor receptor antibody cetu... DisGeNET Detail
The present study was to determine the role of KRAS status in EGFR antibody treatment for gastric ca... DisGeNET Detail
Many molecular pathways are currently under investigation as therapeutic targets in gastric cancer, ... DisGeNET Detail
These results support the involvement of EGFR and HER2 in gastric cancer and suggest an interesting ... DisGeNET Detail
Inhibition of epidermal growth factor receptor signaling prohibits metastasis of gastric cancer via ... DisGeNET Detail
Identification of EGFR expression status association with metastatic lymph node density (ND) by expr... DisGeNET Detail
Patients with HER2(+) /EGFR(+) /MET(+) GCs had a substantial risk of death with a hazard ratio of 3.... DisGeNET Detail
Knockdown of EGFR inhibits growth and invasion of gastric cancer cells. DisGeNET Detail
Gastric cancer in young vs old Romanian patients: immunoprofile with emphasis on maspin and mena pro... DisGeNET Detail
The prevalence of genomic copy number aberrations of epidermal growth factor receptor (EGFR), human ... DisGeNET Detail
In addition, synergy in growth inhibition was observed when the GC cells were treated with a combina... DisGeNET Detail
The results demonstrated that EGFR phosphorylation was markedly inhibited in gastric cancer cell lin... DisGeNET Detail
Cetuximab, an immunoglobulin G1 chimeric monoclonal antibody directed against the epidermal growth f... DisGeNET Detail
EGFR gene polymorphisms -216G>T and -191C>A are risk markers for gastric cancer in Mexican populatio... DisGeNET Detail
In gastric cancer (GC), epidermal growth factor receptor (EGFR) overexpression associates with poor ... DisGeNET Detail
EGFR as a potential therapeutic target for a subset of muscle-invasive bladder cancers presenting a ... DisGeNET Detail
Dual regulation of receptor tyrosine kinase genes EGFR and c-Met by the tumor-suppressive microRNA-2... DisGeNET Detail
The epidermal growth factor receptor (EGFR) family is reportedly overexpressed in bladder cancer, an... DisGeNET Detail
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Using the Snapshot assay, mutation statuses were detected for EGFR, Kirsten rate sarcoma viral oncog... DisGeNET Detail
Clinically, EGFR inhibitors are ineffective as single agent compounds in patients with recurrent NB,... DisGeNET Detail
To show additional prognostic information about the mutational profile and new International Associa... DisGeNET Detail
A prospective, multicentre phase II trial of low-dose erlotinib in non-small cell lung cancer patien... DisGeNET Detail
The aim of the present study was to examine EGFR on protein level, confronting cellular pattern of e... DisGeNET Detail
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Lung and renal cancer, two areas in which huge progress has been made in the last decade, will be us... DisGeNET Detail
Molecular interaction of a kinase inhibitor midostaurin with anticancer drug targets, S100A8 and EGF... DisGeNET Detail
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The epidermal growth factor receptor critically regulates endometrial function during early pregnanc... DisGeNET Detail
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TCDC also increased the expression of epidermal growth factor receptor (EGFR) ligands and TACE activ... DisGeNET Detail
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Anti-EGFR antibody reduces lung nodules by inhibition of EGFR-pathway in a model of lymphangioleiomy... DisGeNET Detail
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Transgenic mice heterozygous for a Trp53-null allele and overexpressing EGFR in Schwann cells had a ... DisGeNET Detail
Next, the identification of less EGFR mutations in the EGFR gene of the pleural mesothelioma an up t... DisGeNET Detail
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RTK expression (c-Kit, c-Met, AXL, HER-1, HER-2, IGF-1R) in pre-/post-imatinib (IM) GIST patient sam... DisGeNET Detail
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Correlations Between the EGFR Mutation Status and Clinicopathological Features of Clinical Stage I L... DisGeNET Detail
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The initial set of trials will focus on different questions: (1) Exceptional Responders Initiative-w... DisGeNET Detail
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Activation of EGFR signaling pathway leads to prostate cancer bone metastasis; however, therapies ta... DisGeNET Detail
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Strong adverse effect of epidermal growth factor receptor 2 overexpression on prognosis of patients ... DisGeNET Detail
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Yes-associated protein (YAP) has been reported to be associated with the prognosis of various cancer... DisGeNET Detail
The crosstalk between PAFR and EGFR suggests a potentially important signaling linkage between infla... DisGeNET Detail
We found that ErbB-1 was localized predominantly in the nucleus of ovarian cancer cells examined, co... DisGeNET Detail
Of the two postulated miR-7 target genes we examined, BCL2, but not EGFR, seems to be a possible miR... DisGeNET Detail
Both epidermal growth factor receptor (EGFR) and fibroblast growth factor receptor 1 (FGFR1) are ove... DisGeNET Detail
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Gene regulatory biomarker identification for skin toxicities induced by EGFR inhibitor treatment. DisGeNET Detail
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HRAS mutations and resistance to the epidermal growth factor receptor tyrosine kinase inhibitor erlo... DisGeNET Detail
If ultimately shown to reduce the risk of oral cancer, chemoprevention with EGFR inhibitors may sign... DisGeNET Detail
Influence of epidermal growth factor receptor expression on the cetuximab and panitumumab response r... DisGeNET Detail
Increased growth-inhibitory and cytotoxic activity of arsenic trioxide in head and neck carcinoma ce... DisGeNET Detail
Targeted therapy against the epidermal growth factor receptor (EGFR) only variably represents a ther... DisGeNET Detail
The tumor antigen (TA)-targeted monoclonal antibodies (mAb) cetuximab and panitumumab target the hum... DisGeNET Detail
These findings underscore the importance of ADAM17 and suggest that D1(A12) might be an effective ta... DisGeNET Detail
The expression and subcellular localization of β-catenin and EGFR activation were also studied in HP... DisGeNET Detail
The epidermal growth factor receptor (EGFR) is a transmembrane tyrosine kinase receptor and is overe... DisGeNET Detail
We investigated the effects of cetuximab (EGFR antibody) and IMC-A12 (IGF-1R antibody) on the respon... DisGeNET Detail
Identification of epidermal growth factor receptor (EGFR) genetic variants that modify risk for head... DisGeNET Detail
We show that upon EGF stimulation, EGFR and RhoC were strongly activated in HNSCC. DisGeNET Detail
Further, large scale automated alignment of sequencing are unlikely to identify EGFRvIII and an assa... DisGeNET Detail
However, many patients with HNSCC respond poorly to the EGFR inhibitors (EGFRI) cetuximab and erloti... DisGeNET Detail
Epidermal growth factor receptor (EGFR) and its downstream elements are overexpressed in most cases ... DisGeNET Detail
Cetuximab is the only approved molecular targeting agent for HNSCC and despite ubiquitous expression... DisGeNET Detail
To date, cetuximab is the only FDA-approved anti-epidermal growth factor receptor therapy for the tr... DisGeNET Detail
Breast cancer 1 (BRCA1)-associated breast cancers are mostly basal-like high-grade ductal carcinomas... DisGeNET Detail
Short telomere lengths have been previously associated with triple-negative and human epidermal grow... DisGeNET Detail
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EGFR (exons 18-21) and Kirsten RNA-associated rat sarcoma 2 virus (exon 2) mutations were determined... DisGeNET Detail
Compared with patients with ALK(-) lung adenocarcinomas (33 patients; 12 with epidermal growth facto... DisGeNET Detail
De novo pulmonary small cell carcinomas and large cell neuroendocrine carcinomas harboring EGFR muta... DisGeNET Detail
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Thus, the association between diverse activating mutations in EGFR and other subclonal mutations wit... DisGeNET Detail
Surprisingly, the authors identify convergent evolution of multiple, mutually exclusive, independent... DisGeNET Detail
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The aim of this study was to compare colorectal adenocarcinoma with mucinous component, ordinary ade... DisGeNET Detail
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EGFR(epidermal growth factor receptor) mutations and ALK(anaplastic lymphoma kinase) rearrangement a... DisGeNET Detail
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All of the cases of six cerebellar GBMs were p53‑positive and EGFR‑negative, as detected by immunost... DisGeNET Detail
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Ovarian serous carcinomas (n=112) and solid metastases (n=63; total=175) were analyzed for mRNA expr... DisGeNET Detail
Cotargeting of epidermal growth factor receptor and PI3K overcomes PI3K-Akt oncogenic dependence in ... DisGeNET Detail
Previous studies have demonstrated that combinatorial treatment of PDAC xenografts with the mitogen-... DisGeNET Detail
Inactivating Sox9 expression in mice confirmed its role in PDAC initiation; it demonstrated that Sox... DisGeNET Detail
These results suggest that dysregulation of ubiquitination is a key mechanism of EGFR hyperactivatio... DisGeNET Detail
(i) hERG1 was expressed at high levels in 59% of primary PDAC; (ii) hERG1 blockade decreased PDAC ce... DisGeNET Detail
Proteomic analysis evidenced that MEK1 inhibition was accompanied by a sustained activation of the P... DisGeNET Detail
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We proposed to investigate the distribution of concurrent oncogene mutations in stage Ib lung adenoc... DisGeNET Detail
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EGFR mutations were previously found in patients suffering from peritoneal mesothelioma but have not... DisGeNET Detail
Next, the identification of less EGFR mutations in the EGFR gene of the pleural mesothelioma an up t... DisGeNET Detail
Lung and renal cancer, two areas in which huge progress has been made in the last decade, will be us... DisGeNET Detail
Molecular interaction of a kinase inhibitor midostaurin with anticancer drug targets, S100A8 and EGF... DisGeNET Detail
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In addition to the well-known characteristics of patients carrying EGFR mutations (female, adenocarc... DisGeNET Detail
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For example, CDH3 was significantly up-regulated in the stromals of both breast and prostate tumors,... DisGeNET Detail
Positive Interplay Between CD3+ T-lymphocytes and Concurrent COX-2/EGFR Expression in Canine Maligna... DisGeNET Detail
Epidermal growth factor-receptor activation modulates Src-dependent resistance to lapatinib in breas... DisGeNET Detail
Impact of epidermal growth factor receptor and transforming growth factor-α on hepatitis C virus-ind... DisGeNET Detail
Mutant p53 Amplifies Epidermal Growth Factor Receptor Family Signaling to Promote Mammary Tumorigene... DisGeNET Detail
Correlation between EGFR amplification and the expression of microRNA-200c in primary glioblastoma m... DisGeNET Detail
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Basal cell carcinoma of the prostate is an aggressive tumor with frequent loss of PTEN expression an... DisGeNET Detail
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In this study, the role of EGFR in tumor angiogenesis was examined in H292 NSCLC cells under the pre... DisGeNET Detail
EGFR is involved in the tumor angiogenesis of HNSCC via the HIF-1α and Notch1 pathways. DisGeNET Detail
Association of EGFR expression level and cetuximab activity in patient-derived xenograft models of h... DisGeNET Detail
Moreover, combined therapeutic inhibition of EGFR and c-Kit may abrogate this acquired mechanism of ... DisGeNET Detail
In vivo studies using mouse xenograft models of CRC showed that Erbin promotes tumour growth, and th... DisGeNET Detail
We engineered the human NSCLC cell line PC-9 (MET-positive cells harboring an exon 19 deletion of EG... DisGeNET Detail
Breast cancer 1 (BRCA1)-associated breast cancers are mostly basal-like high-grade ductal carcinomas... DisGeNET Detail
Short telomere lengths have been previously associated with triple-negative and human epidermal grow... DisGeNET Detail
Approaches used in this investigation include: bioluminescence imaging (BLI) for monitoring intracra... DisGeNET Detail
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Interestingly, the extent of these SHP2 signaling regulatory functions is diminished in glioblastoma... DisGeNET Detail
These findings may explain reports on the common occurrence of mutant EGFR (EGFRvIII) and EGFR expan... DisGeNET Detail
Whole genome sequencing of glioblastoma multiforme identifies multiple structural variations involve... DisGeNET Detail
Although EGFR phosphorylation and STAT3 activation are essential for the maintenance of GBM cancer s... DisGeNET Detail
Tf-NP-miR-1 treatment on GBM spheres significantly inhibited migration of GBM spheres by 30-50% with... DisGeNET Detail
Together with our previous findings, these data suggest that GRh2 may suppress GBM growth through it... DisGeNET Detail
EGFR gene amplification also represents a signature of genetic abnormality in GBM. DisGeNET Detail
Elevated expression of Notch-1 and EGFR induced apoptosis in glioblastoma multiforme patients. DisGeNET Detail
A common characteristic of glioblastoma multiforme histology is EGFR amplification, which affects si... DisGeNET Detail
Endogenous expressions of EGFR in various GBM cells were determined by western blotting. DisGeNET Detail
By immunohistochemistry EGFR and TGF-α were overexpressed in HCC and cirrhotic cases compared to CHC... DisGeNET Detail
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Erlotinib combined with pemetrexed/cisplatin may be effective in the treatment of LM in EGFR mutatio... DisGeNET Detail
It represents a potential therapeutic option against LM after failure of standard-dose EGFR-TKIs, es... DisGeNET Detail
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EGFR mutations may play an important role in the formation of MPE. DisGeNET Detail
SERS measurement based on sea-urchin-like AuNC was an efficient method for EGFR mutation detection i... DisGeNET Detail
Metastatic RET-rearranged lung adenocarcinoma patients with MPE might have favorable survival compar... DisGeNET Detail
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These new findings about endometrial cancer suggest a potential for targeted therapy with lapatinib,... DisGeNET Detail
The protein expression of PCNA and EGFR was significantly higher in high-grade than low-grade glioma... DisGeNET Detail
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This study suggests that γ-H2AX is associated with angiogenesis of HCC and γ-H2AX or a combination o... DisGeNET Detail
B3GNT2, a polylactosamine synthase, regulates glycosylation of EGFR in H7721 human hepatocellular ca... DisGeNET Detail
UNC50 prompts G1/S transition and proliferation in HCC by regulation of epidermal growth factor rece... DisGeNET Detail
These results suggested that ECHS1 may promote cell proliferation in HCC in an EGFR-dependent manner... DisGeNET Detail
Overexpression of EGFR in HCC patients can be promising in selecting those who can get benefit from ... DisGeNET Detail
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Expression levels of p16, β-catenin, and epidermal growth factor receptor (EGFR) were examined in OP... DisGeNET Detail
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Although KRAS mutation has a predictive role in stage IV colorectal cancer (CRC) patients treated wi... DisGeNET Detail
We assume that the LCNEC originated from the adenocarcinoma based on the fact that the patient was a... DisGeNET Detail
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Despite the efficacy and superiority of EGFR TKIs over chemotherapy as first-line therapy, all patie... DisGeNET Detail
Triple-negative breast cancer (TNBC) is a distinct breast cancer subtype defined by the absence of e... DisGeNET Detail
Mutations in exons 19 and 21 of EGFR are commonly found to be associated with non small cell lung ca... DisGeNET Detail
In aggressive, triple-negative, basal-like breast cancers, most tumors display increased MEK and ERK... DisGeNET Detail
Abrogating phosphorylation of eIF4B is required for EGFR and mTOR inhibitor synergy in triple-negati... DisGeNET Detail
When TNBCs were divided into basal (cytokeratin 5/6 (CK5/6)+ and/or epidermal growth factor receptor... DisGeNET Detail
We used cell line models of EGFR-positive/PTEN null TNBC to elucidate the signaling networks that dr... DisGeNET Detail
Ad-p53 enhances the sensitivity of triple-negative breast cancer MDA-MB-468 cells to the EGFR inhibi... DisGeNET Detail
The further determination of how the NHERF1‑EGFR interaction is regulated may improve our understand... DisGeNET Detail
The distinct expression of AR and EGFR and the prevalence of BRCA1 mutation indicated that AR, EGFR,... DisGeNET Detail
Triple negative breast cancer (TNBC) is a distinct breast cancer subtype, which is defined by the ab... DisGeNET Detail
Here, we describe how PEA-15 expression affects the dephosphorylation of epidermal growth factor rec... DisGeNET Detail
Neurokinin-1 activation affects EGFR related signal transduction in triple negative breast cancer. DisGeNET Detail
Signaling via epidermal growth factor receptor (EGFR) and Src kinase pathways promote triple-negativ... DisGeNET Detail
The expression of p53 was higher in luminal B, HER2-enriched, and triple-negative breast cancers, an... DisGeNET Detail
EGFR is one of the best-validated driver genes for TNBC. DisGeNET Detail
Strong adverse effect of epidermal growth factor receptor 2 overexpression on prognosis of patients ... DisGeNET Detail
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Inhibition of USP8 or EGFR is promising for treating USP8-mutated corticotrophin adenoma. DisGeNET Detail
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Amphiregulin is a member of the family of epidermal growth factor receptor (EGFR) agonists with cell... DisGeNET Detail
These findings provide important information on the mechanisms involved in the progression of astroc... DisGeNET Detail
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EGFR as a potential therapeutic target for a subset of muscle-invasive bladder cancers presenting a ... DisGeNET Detail
Dual regulation of receptor tyrosine kinase genes EGFR and c-Met by the tumor-suppressive microRNA-2... DisGeNET Detail
The epidermal growth factor receptor (EGFR) family is reportedly overexpressed in bladder cancer, an... DisGeNET Detail
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The mechanisms that drive therapeutic resistance to EGFR inhibitors in brain tumours are not well de... DisGeNET Detail
Here, human brain tumor-initiating cell (BTIC) lines with different combinations of endogenous EGFR ... DisGeNET Detail
Optical imaging of targeted β-galactosidase in brain tumors to detect EGFR levels. DisGeNET Detail
The naturally secreted and O-GlcNAcylated MIF binds to EGFR, thereby inhibiting the binding of EGF t... DisGeNET Detail
A new class of protein cancer biomarker candidates: differentially expressed splice variants of ERBB... DisGeNET Detail
Complete pharmacologic EGFR/HER2 inhibition is required to reverse Src-dependent resistance to lapat... DisGeNET Detail
This is a revised case report of a 52 year old Caucasian female with Li-Fraumeni syndrome with a rar... DisGeNET Detail
We suggest that TJE is a new potential reagent for EGFR-targeted therapy and anti-abnormal metastasi... DisGeNET Detail
The targeting of the hormone receptor, HER2 and EGFR1 in breast cancer will be reviewed in associati... DisGeNET Detail
The epidermal growth factor receptor (EGFR) is a member of the ErbB family that can promote the migr... DisGeNET Detail
Here, we report a proof-of-concept experiment demonstrating that small peptides interfering with the... DisGeNET Detail
Our results showed that CD44 expression was significantly increased by epidermal growth factor recep... DisGeNET Detail
Prognostic and predictive values of EGFR overexpression and EGFR copy number alteration in HER2-posi... DisGeNET Detail
In both the primary cancers and the metastases, Claudin-4 was most frequently expressed, followed by... DisGeNET Detail
BRCA1 regulation of epidermal growth factor receptor (EGFR) expression in human breast cancer cells ... DisGeNET Detail
Because mutations within HER1/EGFR are predictive of response to tyrosine kinase inhibitors (TKI) in... DisGeNET Detail
Oncogenic signaling in amphiregulin and EGFR-expressing PTEN-null human breast cancer. DisGeNET Detail
Coexpression of EGFR and HER2 has been associated with poor disease outcome, high rates of metastasi... DisGeNET Detail
While ERBB1, ERBB2 and ERBB3 are often overexpressed or activated in breast cancer, and are oncogeni... DisGeNET Detail
We propose that miR-7 regulated pathways, including EGFR and Src kinase, represent targets for the t... DisGeNET Detail
Estrogen-responsive genes most significantly influenced by cohesin were enriched in pathways associa... DisGeNET Detail
This study identifies mutant p53 as an essential player in ErbB2 and EGFR-mediated mammary tumorigen... DisGeNET Detail
TXNIP interaction with the Her-1/2 pathway contributes to overall survival in breast cancer. DisGeNET Detail
Lapatinib, a dual tyrosine kinase inhibitor that interrupts the epidermal growth factor receptor (EG... DisGeNET Detail
Amplified HER2, which encodes a member of the epidermal growth factor receptor (EGFR) family, is a t... DisGeNET Detail
Further understanding of the paradoxical function of EGFR between primary and metastatic tumors will... DisGeNET Detail
Loss of catalytically functional PTPN14 increased the secretion of growth factors and cytokines, suc... DisGeNET Detail
More and more evidences demonstrate that androgen receptor (AR), epidermal growth factor receptor (E... DisGeNET Detail
Epidermal growth factor receptor and AKT1 gene copy numbers by multi-gene fluorescence in situ hybri... DisGeNET Detail
A benzimidazole derivative exhibiting antitumor activity blocks EGFR and HER2 activity and upregulat... DisGeNET Detail
To identify a prognostic signature for breast cancer, we performed DNA methylation profiling and ide... DisGeNET Detail
Kindlin-2 interacts with and stabilizes EGFR and is required for EGF-induced breast cancer cell migr... DisGeNET Detail
Upregulation of HER3 has been found to be a major mechanism underlying drug resistance to EGFR and H... DisGeNET Detail
Endocrine therapy considerations in postmenopausal patients with hormone receptor positive, human ep... DisGeNET Detail
Correlation between p53 and epidermal growth factor receptor expression in breast cancer classificat... DisGeNET Detail
Using the MCF10A/MCF10CA1a Breast Cancer Progression Cell Line Model to Investigate the Effect of Ac... DisGeNET Detail
Requirement of ERα and basal activities of EGFR and Src kinase in Cd-induced activation of MAPK/ERK ... DisGeNET Detail
The majority of breast cancers present with estrogen receptor (ER)-positive and human epidermal grow... DisGeNET Detail
Thirty-two locally/systemically advanced breast cancers treated with first-line fulvestrant (250 mg/... DisGeNET Detail
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Here we show a clear correlation between the efficacy of anti-EGFR inhibitors with their ability to ... DisGeNET Detail
These results indicate that ERBB3 is a potential target for EGFR- and ERBB2-resistant colon cancer t... DisGeNET Detail
Importantly, hyperactivation of SRC/EGFR signaling triggered by loss of PTPRO leads to high resistan... DisGeNET Detail
EZH2 inhibition enhances the efficacy of an EGFR inhibitor in suppressing colon cancer cells. DisGeNET Detail
KRAS mutations also induce anti-EGFR antibody resistance in adenocarcinoma such as colon cancer. DisGeNET Detail
Mutations at the K-RAS locus in colon cancer cells are frequently associated with lack of responsive... DisGeNET Detail
In contrast, forced expression of MITF in melanoma and colon cancer cells inhibited EGFR and conferr... DisGeNET Detail
These new findings about endometrial cancer suggest a potential for targeted therapy with lapatinib,... DisGeNET Detail
Higher expression of the EGFR cascade in cannabis smokers revealed that cannabis smoking may be a ma... DisGeNET Detail
Molecular Characterization of KRAS, BRAF, and EGFR Genes in Cases with Prostatic Adenocarcinoma; Rep... DisGeNET Detail
EGFR ligands and DNA repair genes: genomic predictors of complete response after capecitabine-based ... DisGeNET Detail
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We assume that the LCNEC originated from the adenocarcinoma based on the fact that the patient was a... DisGeNET Detail
A significantly higher incidence of EGFR mutations was observed in bronchioloalveolar carcinomas (28... DisGeNET Detail
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A single-institute cohort study in Taiwan was performed to determine the mutations of epidermal grow... DisGeNET Detail
The clinicopathological significance of ALK rearrangements and KRAS and EGFR mutations in primary pu... DisGeNET Detail
The aim of this study was to compare colorectal adenocarcinoma with mucinous component, ordinary ade... DisGeNET Detail
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Overlapped Transcript Coordinates

Gene Transcript ID Exon Number Chromosome Start Stop Type Amino Mutation Transcript Position Links

Overlapped Transcript

Gene Transcript ID Chromosome Start Stop Links
Gene
-
dbSNP
rs17337023 dbSNP
Genome
hg19
Position
chr7:55,086,710-55,279,321
Variant Type
snv
Variant (CIViC) (CIViC Variant)
3' UTR MUTATION
Variant URL (CIViC Variant)
https://civic.genome.wustl.edu/links/variants/253
Variant (CIViC) (CIViC Variant)
S752_I759delSPKANKEI
Variant URL (CIViC Variant)
https://civic.genome.wustl.edu/links/variants/891
Variant (CIViC) (CIViC Variant)
V851I
Variant URL (CIViC Variant)
https://civic.genome.wustl.edu/links/variants/1466
Variant (CIViC) (CIViC Variant)
V774_C775insHV
Variant URL (CIViC Variant)
https://civic.genome.wustl.edu/links/variants/1567
Variant (CIViC) (CIViC Variant)
D770_N771insNPG
Variant URL (CIViC Variant)
https://civic.genome.wustl.edu/links/variants/1569
Variant (CIViC) (CIViC Variant)
D770_N771insGY
Variant URL (CIViC Variant)
https://civic.genome.wustl.edu/links/variants/1666
Variant (CIViC) (CIViC Variant)
P772_H773insYNP
Variant URL (CIViC Variant)
https://civic.genome.wustl.edu/links/variants/1667
Variant (CIViC) (CIViC Variant)
P772_V774insPHV
Variant URL (CIViC Variant)
https://civic.genome.wustl.edu/links/variants/1668
Variant (CIViC) (CIViC Variant)
Ex19 del L858R
Variant URL (CIViC Variant)
https://civic.genome.wustl.edu/links/variants/1854
Variant (CIViC) (CIViC Variant)
RARE EX 18-21 MUT
Variant URL (CIViC Variant)
https://civic.genome.wustl.edu/links/variants/1863
Summary (CIViC Variant)
Rare exon 18-21 mutations in EGFR consist of all EGFR mutations excluding sensitizing L858R substitutions and exon 19 deletions, as well as resistance mutation T790M.
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