lymphangioleiomyomatosis
Information
- Disease name
- lymphangioleiomyomatosis
- Disease ID
- DOID:3319
- Description
- "A lung disease that is characterized by progressive cystic destruction of the lung and lymphatic abnormalities, frequently associated with renal angiomyolipomas." [url:https\://pubmed.ncbi.nlm.nih.gov/31610670/]
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
| Genes | Mutation | Description | Source | Links |
|---|
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT01552434 | Active, not recruiting | Phase 1 | Bevacizumab and Temsirolimus Alone or in Combination With Valproic Acid or Cetuximab in Treating Patients With Advanced or Metastatic Malignancy or Other Benign Disease | March 16, 2012 | March 31, 2026 |
| NCT03131999 | Completed | Phase 1/Phase 2 | LAM Pilot Study With Imatinib Mesylate | January 23, 2018 | March 7, 2019 |
| NCT00457808 | Completed | Phase 2 | Rapamycin Therapy for Patients With Tuberous Sclerosis Complex and Sporadic LAM | December 2002 | March 2006 |
| NCT03253913 | Completed | Phase 2 | Resveratrol and Sirolimus in Lymphangioleiomyomatosis Trial | March 31, 2018 | October 15, 2022 |
| NCT00457964 | Completed | Phase 1/Phase 2 | RAD001 Therapy of Angiomyolipomata in Patients With TS Complex and Sporadic LAM | August 2005 | July 2013 |
| NCT04184193 | Completed | Benefits of Pulmonary Rehabilitation in Patients With Severe Lymphangioleiomyomatosis (LAM) | December 3, 2019 | December 23, 2019 | |
| NCT00552955 | Completed | Effect of Fasting on the Size of Abdominal Lymphatic Tumors in Women | October 26, 2007 | March 21, 2016 | |
| NCT00960895 | Completed | Pulmonary Hypertension in Lymphangioleiomyomatosis | August 2009 | December 2010 | |
| NCT00989742 | Completed | Phase 4 | Doxycycline In Lymphangioleiomyomatosis (LAM) | July 2009 | January 2013 |
| NCT01059318 | Completed | Phase 2 | A Study to Determine the Safety and Effectiveness of RAD001 (Everolimus) in Patients With Lymphangioleiomyomatosis | January 2010 | June 2012 |
| NCT01353209 | Completed | Phase 2 | Letrozole for Lymphangioleiomyomatosis | May 2011 | September 2014 |
| NCT00005906 | Completed | Phase 2 | Treatment With Octreotide in Patients With Lymphangioleiomyomatosis | June 2000 | |
| NCT02859194 | Completed | N/A | The Effect of Lt to Rt Shunt Using Veno-veno-arterial Extracorporeal Membrane Oxygenation (ECMO) on Coronary Oxygenation in Lung Transplantation Patients | May 31, 2016 | October 14, 2016 |
| NCT03062943 | Completed | Phase 2 | A Study of Nintedanib for LymphAngioleioMyomatosis (LAM) | December 6, 2016 | December 2021 |
| NCT01687179 | Completed | Phase 1 | Safety Study of Sirolimus and Hydroxychloroquine in Women With Lymphangioleiomyomatosis | September 2012 | August 2015 |
| NCT00366509 | Completed | Role of Helicobacter Pylori and Its Toxins in Lung and Digestive System Diseases | September 18, 2006 | October 27, 2016 | |
| NCT02009241 | Completed | N/A | Pulmonary Rehabilitation in Lymphangioleiomyomatosis | November 2013 | May 2015 |
| NCT02061397 | Completed | Phase 1/Phase 2 | Safety of Simvastatin in LAM and TSC | March 2014 | December 13, 2019 |
| NCT02325505 | Completed | Characterization of Patients With Tuberous Sclerosis Complex, Lymphangioleiomyomatosis and Angiomyolipoma | April 2016 | August 2022 | |
| NCT00414648 | Completed | Phase 3 | Efficacy and Safety of Sirolimus in LAM | December 2006 | February 2011 |
| NCT05323370 | Completed | Lymphangioleiomyomatosis, a Study on Cathepsin K | May 31, 2022 | October 30, 2022 | |
| NCT05727852 | Enrolling by invitation | Breath Analysis and Arterial Stiffness in Patients With Respiratory Diseases | January 30, 2023 | December 2026 | |
| NCT06160310 | Recruiting | Tuberous Sclerosis Complex and Lymphangioleiomyomatosis Pregnancy Registry (TSC-LAM Registry) | July 1, 2023 | July 1, 2029 | |
| NCT01484236 | Recruiting | National Lymphangioleiomyomatosis Registry, France | January 2012 | December 2025 | |
| NCT01799538 | Recruiting | Phase 1/Phase 2 | Nebulized or Inhaled Albuterol for Lymphangioleiomyomatosis | June 10, 2013 | November 1, 2026 |
| NCT02432560 | Recruiting | Safety and Durability of Sirolimus for Treatment of LAM | March 2015 | July 31, 2025 | |
| NCT03150914 | Recruiting | Phase 3 | Multicenter Interventional Lymphangioleiomyomatosis (LAM) Early Disease Trial | January 1, 2018 | June 30, 2025 |
| NCT03304678 | Recruiting | Phase 2 | Discovery of Sirolimus Sensitive Biomarkers in Blood | December 4, 2017 | September 30, 2025 |
| NCT05467397 | Recruiting | Phase 1/Phase 2 | Feasibility of [11C]Acetate-PET in LAM and TSC | August 30, 2021 | December 31, 2023 |
| NCT05676099 | Recruiting | TSC Biosample Repository and Natural History Database | January 2016 | December 2050 | |
| NCT00001465 | Recruiting | Study of the Disease Process of Lymphangioleiomyomatosis | December 18, 1995 | ||
| NCT02654340 | Terminated | Biomarkers for Tuberous Sclerosis Complex (BioTuScCom) | August 1, 2018 | December 30, 2022 | |
| NCT00490789 | Unknown status | Phase 2 | Trial of Efficacy and Safety of Sirolimus in Tuberous Sclerosis and LAM | October 2005 | September 2009 |
| NCT04577937 | Unknown status | N/A | Sleep Patterns in Patients Affected by Lymphangioleiomiomatosis | June 30, 2020 | November 1, 2021 |
| NCT05087134 | Unknown status | Early Phase 1 | Characterizing LAM With 11C-Choline PET/CT | November 2021 | September 2023 |
| NCT05190627 | Unknown status | Phase 2 | Effect of Loratadine in Lymphangioleiomyomatosis | November 1, 2021 | December 30, 2023 |
- Disase is a (Disease Ontology)
- DOID:850
- Cross Reference ID (Disease Ontology)
- GARD:3319
- Cross Reference ID (Disease Ontology)
- ICDO:9174/1
- Cross Reference ID (Disease Ontology)
- MIM:606690
- Cross Reference ID (Disease Ontology)
- NCI:C38153
- Cross Reference ID (Disease Ontology)
- ORDO:538
- Cross Reference ID (Disease Ontology)
- SNOMEDCT_US_2023_03_01:277844007
- Cross Reference ID (Disease Ontology)
- UMLS_CUI:C0349649
- Exact Synonym (Disease Ontology)
- lung lymphangioleiomyomatosis
- Exact Synonym (Disease Ontology)
- lymphangiomyomatosis
- Exact Synonym (Disease Ontology)
- pulmonary lymphangioleiomyomatosis
- OrphaNumber from OrphaNet (Orphanet)
- 538
- MeSH unique ID (MeSH (Medical Subject Headings))
- D018192