chr7:100770385:> Detail (hg19)

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Summary
Information
Links
Disease area statistics
MGeND
ClinVar
CIViC
DisGeNET
Annotation
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Information

Genome

Assembly	Position
hg19	chr7:100,770,385-100,782,528
hg38	chr7:101,127,104-101,139,247

HGVS

RefSeq

Type	Transcript	Protein

Summary

MGeND

Clinical significance
Variant entry
GWAS entry
Disease area statistics	Show details

Frequency

[No Data.]

Prediction

[No Data.]

ClinVar

Clinical Significance
Review star	[No Data.]
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Links

Disease area statistics

[No Data.]

MGeND

[No Data.]

ClinVar

[No Data.]

CIViC

[No Data.]

DisGeNET

Score	Disease name	Description	Source	Pubmed	Links
0.004	squamous cell carcinoma	NA	BeFree,LHGDN		Detail
<0.001	Cardiomyopathy, Dilated	NA	BeFree		Detail
0.049	Cardiovascular Diseases	This review provides an overview on the current knowledge on PAI-1 especially im...	BeFree,GAD,LHGDN	25386620	Detail
0.002	carotid stenosis	NA	GAD		Detail
0.003	intracranial aneurysm	NA	BeFree,GAD		Detail
0.002	Cerebral Arterial Diseases	NA	GAD		Detail
0.006	cerebral infarction	NA	BeFree,GAD		Detail
0.009	brain ischemia	NA	GAD		Detail
0.007	cerebral palsy	NA	GAD		Detail
0.002	Cerebrovascular Disorders	NA	GAD		Detail
0.001	Malignant tumor of cervix	NA	BeFree		Detail
0.120	cholestasis	NA	CTD_human		Detail
0.002	chorioamnionitis	NA	GAD		Detail
<0.001	colitis	NA	BeFree		Detail
0.003	Colonic Neoplasms	NA	BeFree,LHGDN		Detail
0.004	colorectal carcinoma	Furthermore, unlike CEA and PAI-1, up-regulation of TRFM in pathological stages ...	BeFree	25216327	Detail
0.004	colorectal carcinoma	Silencing of plasminogen activator inhibitor-1 suppresses colorectal cancer prog...	BeFree	26275833	Detail
0.003	Colorectal Neoplasms	NA	LHGDN		Detail
<0.001	allergic conjunctivitis	NA	BeFree		Detail
0.002	Connective Tissue Diseases	NA	GAD		Detail
0.003	coronary aneurysm	NA	LHGDN		Detail
0.031	Coronary Arteriosclerosis	NA	BeFree,GAD		Detail
0.020	Coronary heart disease	NA	BeFree,GAD,LHGDN		Detail
<0.001	coronary thrombosis	NA	BeFree		Detail
0.005	Crohn Disease	NA	BeFree,GAD		Detail
<0.001	cystic fibrosis	NA	BeFree		Detail
<0.001	cystitis	NA	BeFree		Detail
0.002	Hearing Loss, Sudden	NA	GAD		Detail
<0.001	Presenile dementia	Our results show that plasma PAI-1 levels gradually increased as dementia progre...	BeFree	25304332	Detail
0.003	Mental Depression	Using data from the borderline subscale of the Personality Assessment Inventory ...	BeFree,GAD	23979607	Detail
<0.001	depressive disorder	Using data from the borderline subscale of the Personality Assessment Inventory ...	BeFree	23979607	Detail
<0.001	scleroderma	NA	BeFree		Detail
0.008	Diabetes	Role of plasminogen activator inhibitor-1 in glucocorticoid-induced diabetes and...	BeFree,GAD	25552599	Detail
0.014	diabetes mellitus	Role of plasminogen activator inhibitor-1 in glucocorticoid-induced diabetes and...	BeFree,GAD	25552599	Detail
0.120	Diabetes Mellitus, Experimental	NA	CTD_human		Detail
<0.001	Diabetes Mellitus, Insulin-Dependent	NA	BeFree		Detail
0.120	Diabetes Mellitus, Non-Insulin-Dependent	Patients with type 2 diabetes showed increased expression of PAI-1, indicative o...	BeFree,GAD,RGD	25496999	Detail
<0.001	Diabetic Angiopathies	NA	BeFree		Detail
0.203	Diabetic Nephropathy	NA	BeFree,CTD_human,RGD		Detail
0.007	diabetic retinopathy	NA	BeFree,GAD,LHGDN		Detail
0.005	disseminated intravascular coagulation	NA	BeFree,GAD,LHGDN		Detail
<0.001	duodenal ulcer	NA	BeFree		Detail
<0.001	Dyspepsia	NA	BeFree		Detail
0.002	eclampsia	NA	BeFree		Detail
0.002	Pathological accumulation of air in tissues	NA	GAD		Detail
0.012	endometriosis	NA	BeFree,GAD,LHGDN		Detail
<0.001	Enteritis	NA	BeFree		Detail
0.123	Fatty Liver	NA	BeFree,CTD_human,LHGDN		Detail
0.002	Fetal Diseases	NA	GAD		Detail
0.002	Fetal Membranes, Premature Rupture	NA	GAD		Detail
0.002	fibromyalgia	NA	GAD		Detail
<0.001	fibrosarcoma	NA	BeFree		Detail
0.008	Fibrosis	NA	LHGDN		Detail
<0.001	gastritis	NA	BeFree		Detail
<0.001	Gastrointestinal Neoplasms	NA	BeFree		Detail
0.002	generalized atherosclerosis	NA	GAD		Detail
0.005	Glaucoma, Open-Angle	NA	GAD,LHGDN		Detail
0.004	glioblastoma	NA	BeFree,LHGDN		Detail
0.008	Glioma	NA	BeFree,LHGDN		Detail
0.003	glomerulonephritis	NA	BeFree,LHGDN		Detail
0.123	IgA glomerulonephritis	Association between plasminogen activator inhibitor-1 4G/5G gene polymorphism an...	BeFree,CTD_human,GAD	24918969	Detail
0.003	membranous glomerulonephritis	NA	BeFree,LHGDN		Detail
0.120	Focal glomerulosclerosis	NA	CTD_human		Detail
0.002	Graft Occlusion, Vascular	NA	GAD		Detail
0.002	Hay fever	NA	GAD		Detail
<0.001	cardiac arrest	NA	BeFree		Detail
0.005	Heart Diseases	NA	BeFree,GAD		Detail
0.120	Heart failure	NA	BeFree,CTD_human		Detail
<0.001	Myocardial rupture	NA	BeFree		Detail
<0.001	Hemangioendothelioma	Penile pseudomyogenic hemangioendothelioma/epithelioid sarcoma-like hemangioendo...	BeFree	25749627	Detail
<0.001	Hemangiosarcoma	NA	BeFree		Detail
0.002	hemolytic-uremic syndrome	NA	GAD		Detail
0.003	Hemophilia A	NA	BeFree,GAD		Detail
0.002	Hemorrhagic Disorders	NA	GAD		Detail
<0.001	Hemorrhagic Fever with Renal Syndrome	NA	BeFree		Detail
<0.001	Hepatic Vein Thrombosis	NA	BeFree		Detail
<0.001	hepatitis B	In conclusion, thrombo and fibro-genetic mechanisms of PAI-1 4G-4G and MTHFR 677...	BeFree	25987440	Detail
0.002	hepatitis C	NA	GAD		Detail
<0.001	HIV Infections	NA	BeFree		Detail
<0.001	Hodgkin Disease	NA	BeFree		Detail
<0.001	Huntington disease	NA	BeFree		Detail
0.006	Hypercholesterolemia	NA	BeFree,GAD,LHGDN		Detail
0.001	Hypercholesterolemia, Familial	NA	BeFree		Detail
0.001	hyperglycemia	NA	BeFree		Detail
0.002	hyperinsulinism	PAI-1 polymorphism was synergistic with hyperinsulinemia.	BeFree	25205258	Detail
0.001	Hyperlipidemia	PAI-1 deficiency significantly reduced insulin resistance and glucose intoleranc...	BeFree	25552599	Detail
0.003	Hyperlipidemia, Familial Combined	NA	BeFree,LHGDN		Detail
0.003	Hyperplasia	NA	LHGDN		Detail
0.002	Immediate hypersensitivity	NA	GAD		Detail
0.175	Hypertensive disease	Hypertension is associated with increased expression of FABP3, FAS, FN1, IL1R2, ...	BeFree,CTD_human,GAD,LHGDN	23337395	Detail
0.175	Hypertensive disease	The presence of type 2 diabetes associated with 3.2-fold increased PAI-1 express...	BeFree,CTD_human,GAD,LHGDN	25496999	Detail
0.003	hyperthyroidism	NA	LHGDN		Detail
0.003	Hypertriglyceridemia	NA	LHGDN		Detail
<0.001	Ileal Diseases	NA	BeFree		Detail
<0.001	Immunologic Deficiency Syndromes	NA	BeFree		Detail
0.002	infertility	NA	GAD		Detail
0.005	Female infertility	NA	GAD		Detail
0.015	Inflammation	NA	GAD,LHGDN		Detail
0.003	Inflammatory Bowel Diseases	NA	BeFree,GAD		Detail
<0.001	influenza	Plasminogen activator inhibitor-1 in cigarette smoke exposure and influenza A vi...	BeFree	25932922	Detail
0.082	Insulin resistance	NA	GAD,RGD		Detail
<0.001	intermittent claudication	NA	BeFree		Detail
<0.001	Intestinal Diseases	NA	BeFree		Detail
<0.001	ischemia	NA	BeFree		Detail
0.003	Keloid	Association of the plasminogen activator inhibitor-1 (PAI-1) Gene -675 4G/5G and...	BeFree	25350781	Detail
<0.001	Keratoconjunctivitis, Vernal	NA	BeFree		Detail
0.009	Kidney Diseases	NA	BeFree,GAD		Detail
0.128	Kidney Failure, Chronic	NA	BeFree,CTD_human,GAD		Detail
<0.001	acute kidney tubular necrosis	NA	BeFree		Detail
<0.001	Klinefelter syndrome	NA	BeFree		Detail
0.002	Premature Obstetric Labor	NA	GAD		Detail
<0.001	Leg Ulcer	NA	BeFree		Detail
<0.001	Fibroid Tumor	NA	BeFree		Detail
<0.001	leiomyosarcoma	NA	BeFree		Detail
0.003	lymphoid leukemia	NA	LHGDN		Detail
<0.001	Acute lymphocytic leukemia	NA	BeFree		Detail
<0.001	lipodystrophy	NA	BeFree		Detail
0.010	liver cirrhosis	In conclusion, thrombo and fibro-genetic mechanisms of PAI-1 4G-4G and MTHFR 677...	BeFree,GAD,LHGDN	25987440	Detail
0.002	Liver Cirrhosis, Alcoholic	NA	GAD		Detail
0.002	Liver diseases	NA	GAD		Detail
0.122	Liver neoplasms	NA	BeFree,CTD_human		Detail
<0.001	Lung diseases	NA	BeFree		Detail
0.090	Chronic Obstructive Airway Disease	We found increased p53, PAI-1 and apoptosis in AECs, with accumulation of macrop...	BeFree,GAD,RGD	25932922	Detail
<0.001	Lupus Vulgaris	NA	BeFree		Detail
<0.001	Lupus Erythematosus, Discoid	NA	BeFree		Detail
0.008	Lupus Erythematosus, Systemic	NA	BeFree,GAD		Detail
0.011	lupus nephritis	NA	BeFree,GAD,LHGDN		Detail
<0.001	Lymphatic Metastasis	Plasma PAI-1 level was higher in CRC patients with liver metastasis and correlat...	BeFree	26275833	Detail
0.005	Malignant neoplasm of stomach	miR-30b may function as a novel tumor suppressor gene in gastric cancer by targe...	BeFree	25170877	Detail
0.004	melanoma	NA	BeFree,LHGDN		Detail
<0.001	meningioma	NA	BeFree		Detail
<0.001	meningitis	NA	BeFree		Detail
<0.001	Meningitis, Pneumococcal	NA	BeFree		Detail
0.019	Meningococcal Infections	NA	BeFree,GAD,LHGDN		Detail
0.001	Meningococcemia	NA	BeFree		Detail
<0.001	Mesothelioma	NA	BeFree		Detail
0.002	Metabolic Diseases	NA	BeFree		Detail
<0.001	Mucocutaneous Lymph Node Syndrome	NA	BeFree		Detail
0.001	multiple myeloma	NA	BeFree		Detail
0.005	Multiple Organ Failure	NA	GAD,LHGDN		Detail
0.006	multiple sclerosis	NA	BeFree,GAD,LHGDN		Detail
0.080	muscular atrophy	In conclusion, the current study indicated that PAI-1 is involved in GC-induced ...	BeFree,RGD	25552599	Detail
<0.001	muscular dystrophy	NA	BeFree		Detail
0.002	Musculoskeletal Diseases	NA	GAD		Detail
<0.001	Myeloproliferative disease	Elevated levels of PAI-1 in MPN patients may result from its increased productio...	BeFree	24509338	Detail
0.173	myocardial infarction	The association between plasminogen activator inhibitor type 1 (PAI-1) levels, P...	BeFree,GAD,LHGDN,RGD	24695040	Detail
0.173	myocardial infarction	We aimed to investigate the association of plasminogen activator inhibitor-1 (PA...	BeFree,GAD,LHGDN,RGD	25113642	Detail
0.173	myocardial infarction	PAI-1 plays a pivotal role in acute thrombotic events such as deep vein thrombos...	BeFree,GAD,LHGDN,RGD	25386620	Detail
<0.001	myoma	NA	BeFree		Detail
0.002	Neoplasm Invasiveness	NA	GAD		Detail
0.020	Neoplasm Metastasis	NA	BeFree,LHGDN		Detail
0.002	Neoplasm Recurrence, Local	NA	GAD		Detail
<0.001	nephritis	NA	BeFree		Detail
0.121	nephrotic syndrome	NA	BeFree,CTD_human		Detail
0.120	nervous system disorder	NA	CTD_human		Detail
<0.001	neuroblastoma	NA	BeFree		Detail
0.002	Fibrosis, Liver	The aim of this work was to establish an association between the single-nucleoti...	BeFree	23941979	Detail
0.001	Virus Diseases	The aim of this work was to establish an association between the single-nucleoti...	BeFree	23941979	Detail
0.164	obesity	NA	BeFree,CTD_human,GAD		Detail
<0.001	Obesity, Morbid	NA	BeFree		Detail
<0.001	oral submucous fibrosis	NA	BeFree		Detail
0.003	Degenerative polyarthritis	NA	BeFree,LHGDN		Detail
<0.001	Osteoarthropathy, Primary Hypertrophic	NA	BeFree		Detail
<0.001	osteomyelitis	NA	BeFree		Detail
0.013	Bone necrosis	NA	GAD,LHGDN		Detail
<0.001	Osteoporosis, Postmenopausal	NA	BeFree		Detail
<0.001	Ear Inflammation	NA	BeFree		Detail
0.003	otitis media	NA	BeFree,LHGDN		Detail
0.004	ovarian carcinoma	Inhibition of plasminogen activator inhibitor-1 is a potential therapeutic strat...	BeFree	25587663	Detail
0.004	ovarian carcinoma	P21, GADD45 and PAI-1 expression were down-regulated in mutant OCCs.	BeFree	25958320	Detail
0.002	Ovarian Diseases	NA	BeFree		Detail
0.003	Pancreatic Neoplasm	NA	LHGDN		Detail
0.002	pancreatitis	NA	GAD		Detail
<0.001	Peyronie Disease	NA	BeFree		Detail
<0.001	Peptic Ulcer	NA	BeFree		Detail
0.003	familial Mediterranean fever	NA	BeFree,GAD		Detail
0.003	Periodontal Diseases	NA	BeFree,LHGDN		Detail
0.006	periodontitis	NA	BeFree,GAD		Detail
<0.001	peritonitis	NA	BeFree		Detail
<0.001	pheochromocytoma	NA	BeFree		Detail
0.002	Placenta Disorders	NA	GAD		Detail
<0.001	placental insufficiency	The 4G/4G polymorphism of the plasminogen activator inhibitor-1 (PAI-1) gene as ...	BeFree	25723084	Detail
0.002	Pneumococcal Infections	NA	GAD		Detail
0.002	pneumoconiosis	NA	GAD		Detail
0.014	pneumonia	These observations indicate that increased PAI-1 expression promotes AEC apoptos...	BeFree,GAD,LHGDN	25932922	Detail
<0.001	Lobar Pneumonia	NA	BeFree		Detail
0.047	polycystic ovary syndrome	4G/5G polymorphism of plasminogen activator inhibitor-1 gene is associated with ...	BeFree,GAD,LHGDN	25731152	Detail
<0.001	polycythemia vera	Concentration of PAI-1:Ag was increased in patients with essential thrombocythem...	BeFree	24509338	Detail
0.003	Adenomatous Polyposis Coli	NA	BeFree,LHGDN		Detail
<0.001	Polyuria	NA	BeFree		Detail
0.005	Postoperative Complications	NA	GAD		Detail
0.005	Postoperative Hemorrhage	NA	GAD		Detail
0.145	pre-eclampsia	NA	CTD_human,GAD,LHGDN		Detail
<0.001	Pregnancy Complications	Hereditary hypofibrinolysis, which is mediated by 4G/4G homozygosity for the PAI...	BeFree	25723084	Detail
0.002	Pregnancy Complications, Cardiovascular	NA	GAD		Detail
0.005	Pregnancy Complications, Hematologic	NA	GAD		Detail
0.123	Prostatic Neoplasms	NA	BeFree,CTD_human,LHGDN		Detail
0.002	Puerperal Disorders	NA	GAD		Detail
<0.001	pulmonary edema	NA	BeFree		Detail
0.008	pulmonary embolism	NA	BeFree,GAD		Detail
<0.001	pulmonary emphysema	NA	BeFree		Detail
0.082	pulmonary fibrosis	The biological effects of PAI-1 extend far beyond thrombosis including its criti...	BeFree,RGD	25386620	Detail
<0.001	pyelonephritis	NA	BeFree		Detail
<0.001	kidney failure	NA	BeFree		Detail
0.006	Respiratory Distress Syndrome, Adult	NA	BeFree,GAD,LHGDN		Detail
0.120	Respiratory Hypersensitivity	NA	CTD_human		Detail
0.002	retinal artery occlusion	NA	GAD		Detail
0.002	Retinal Diseases	NA	BeFree		Detail
0.005	retinal vascular occlusion	NA	GAD		Detail
0.003	retinal vein occlusion	In our study, the FII G20210A and the MTHFR C677T mutations resulted significant...	BeFree,GAD	24569626	Detail
<0.001	rhabdomyosarcoma	NA	BeFree		Detail
0.002	Rhinitis, Allergic, Perennial	NA	GAD		Detail
<0.001	systemic scleroderma	Expression levels of other TGF-β-regulated genes, including SERPINE1 and CTGF, d...	BeFree	26098215	Detail
<0.001	Seizures	NA	BeFree		Detail
<0.001	seminoma	NA	BeFree		Detail
<0.001	Age-related cataract	NA	BeFree		Detail
0.002	Septicemia	NA	BeFree		Detail
0.002	Septic Shock	NA	GAD		Detail
0.003	sinusitis	NA	BeFree,GAD		Detail
<0.001	Skin Abnormalities	NA	BeFree		Detail
0.002	Dermatologic disorders	NA	GAD		Detail
<0.001	Soft Tissue Neoplasms	NA	BeFree		Detail
<0.001	Stomach Diseases	NA	BeFree		Detail
0.128	Stomach Neoplasms	NA	BeFree,CTD_human,GAD,LHGDN		Detail
0.003	gastric ulcer	NA	BeFree,GAD		Detail
0.002	Streptococcal Infections	NA	GAD		Detail
<0.001	Stress, Psychological	NA	BeFree		Detail
0.063	Cerebrovascular accident	Pai-1 gene variants and COC use are associated with stroke risk: a case-control ...	BeFree,GAD,LHGDN	25231632	Detail
0.007	Subarachnoid Hemorrhage	NA	BeFree,GAD		Detail
<0.001	synovitis	NA	BeFree		Detail
0.002	Testicular Neoplasms	NA	GAD		Detail
<0.001	Thrombocythemia, Essential	Concentration of PAI-1:Ag was increased in patients with essential thrombocythem...	BeFree	24509338	Detail
0.004	Thromboembolism	Association between the plasminogen activator inhibitor-1 4G/5G polymorphism and...	BeFree	25450536	Detail
0.174	thrombosis	NA	CTD_human,GAD,LHGDN		Detail
<0.001	Turner syndrome	NA	BeFree		Detail
<0.001	Unipolar Depression	NA	BeFree		Detail
0.080	ureteral obstruction	ATM activation (pATM(Ser1981)) increased 4-fold in the tubulointerstitial region...	BeFree,RGD	25480384	Detail
0.002	Uterine Diseases	NA	GAD		Detail
<0.001	Uterine Fibroids	NA	BeFree		Detail
0.018	Vascular Diseases	The inactivation of plasminogen activator inhibitor-1 (PAI-1) has been shown to ...	BeFree,GAD,LHGDN	25040736	Detail
0.002	venous insufficiency	NA	GAD		Detail
0.102	Venous Thrombosis	NA	GAD,LHGDN,RGD		Detail
0.002	Virilism	NA	GAD		Detail
0.001	Virus Diseases	Plasminogen activator inhibitor-1 in cigarette smoke exposure and influenza A vi...	BeFree	25932922	Detail
0.001	Werner syndrome	NA	BeFree		Detail
<0.001	Yersinia infections	NA	BeFree		Detail
0.003	Cerebral Thrombosis	NA	BeFree,GAD		Detail
0.008	Fibromatosis, Aggressive	NA	BeFree,GAD,LHGDN		Detail
<0.001	Ichthyosis, X-Linked	NA	BeFree		Detail
0.003	Bronchial Hyperreactivity	NA	BeFree,GAD		Detail
0.003	gestational diabetes	NA	BeFree,GAD		Detail
<0.001	Ovarian Failure, Premature	NA	BeFree		Detail
0.008	antiphospholipid syndrome	NA	BeFree,GAD		Detail
0.002	Sudden cardiac death	NA	GAD		Detail
0.001	Polyendocrinopathies, Autoimmune	NA	BeFree		Detail
0.001	essential hypertension	NA	BeFree		Detail
<0.001	Encephalopathies	NA	BeFree		Detail
0.003	Liver failure	NA	LHGDN		Detail
<0.001	Hamman-Rich syndrome	NA	BeFree		Detail
<0.001	Idiopathic Membranous Glomerulonephritis	NA	BeFree		Detail
<0.001	cataract	NA	BeFree		Detail
<0.001	benign neoplasm	NA	BeFree		Detail
<0.001	Left Ventricular Hypertrophy	NA	BeFree		Detail
<0.001	Sepsis due to urinary tract infection	NA	BeFree		Detail
0.014	Deep Vein Thrombosis	PAI-1 4G/5G and MTHFR C677T polymorphisms increased the accuracy of two predicti...	BeFree,GAD	24715181	Detail
0.014	Deep Vein Thrombosis	PAI-1 plays a pivotal role in acute thrombotic events such as deep vein thrombos...	BeFree,GAD	25386620	Detail
<0.001	Small cell carcinoma of lung	NA	BeFree		Detail
<0.001	obstructive nephropathy	NA	BeFree		Detail
<0.001	Adenocarcinoma of rectum	NA	BeFree		Detail
0.012	Premature Birth	NA	GAD		Detail
<0.001	Oral Cavity Carcinoma	NA	BeFree		Detail
<0.001	renal fibrosis	NA	BeFree		Detail
0.012	Myocardial Ischemia	NA	BeFree,GAD		Detail
0.002	Abnormal renal function	NA	GAD		Detail
0.003	Arterial thrombosis	NA	BeFree		Detail
<0.001	Thrombosis of cerebral veins	NA	BeFree		Detail
0.001	Deep thrombophlebitis	NA	BeFree		Detail
<0.001	Idiopathic pulmonary hypertension	NA	BeFree		Detail
<0.001	Chronic glomerulonephritis	NA	BeFree		Detail
0.003	Malignant neoplasm of mouth	NA	BeFree,GAD		Detail
<0.001	Malignant neoplasm of testis	NA	BeFree		Detail
<0.001	Secondary malignant neoplasm of lung	NA	BeFree		Detail
<0.001	Secondary malignant neoplasm of bone	NA	BeFree		Detail
<0.001	proliferative diabetic retinopathy	NA	BeFree		Detail
<0.001	central retinal vein occlusion	NA	BeFree		Detail
0.003	acute myocardial infarction	Relation of PAI-1 and TPA genes polymorphisms to acute myocardial infarction and...	BeFree	25113642	Detail
<0.001	Old myocardial infarction	NA	BeFree		Detail
<0.001	portal vein thrombosis	In conclusion, thrombo and fibro-genetic mechanisms of PAI-1 4G-4G and MTHFR 677...	BeFree	25987440	Detail
<0.001	Streptococcal pneumonia	NA	BeFree		Detail
0.001	allergic asthma	NA	BeFree		Detail
<0.001	Peritoneal adhesion	NA	BeFree		Detail
<0.001	retinal ischemia	NA	BeFree		Detail
<0.001	adrenoleukodystrophy	NA	BeFree		Detail
0.003	Colitis, Ischemic	NA	BeFree,GAD		Detail
<0.001	Cicatrix, Hypertrophic	MiR-10a and miR-181c regulate collagen type I generation in hypertrophic scars b...	BeFree	25554417	Detail
0.005	Aneurysm, Ruptured	NA	GAD		Detail
0.091	Aortic Aneurysm, Abdominal	NA	BeFree,GAD,RGD		Detail
<0.001	Aortic Aneurysm, Thoracic	NA	BeFree		Detail
0.002	Glomerulosclerosis (disorder)	NA	BeFree		Detail
0.003	Tumor Progression	NA	BeFree		Detail
<0.001	histiocytoid hemangioma	Although FOSB-rearranged EH do not show significant morphologic overlap with SER...	BeFree	25043949	Detail
0.002	Community-Acquired Infections	NA	GAD		Detail
<0.001	hepatoblastoma	NA	BeFree		Detail
<0.001	Adenocarcinoma, Clear Cell	Interestingly, expression of PAI-1 was increased in ovarian clear cell carcinoma...	BeFree	25587663	Detail
<0.001	Follicular thyroid carcinoma	NA	BeFree		Detail
<0.001	uveal melanoma	NA	BeFree		Detail
<0.001	Lip and oral cavity carcinoma	NA	BeFree		Detail
0.005	alpha 1-antitrypsin deficiency	NA	GAD		Detail
<0.001	Premature aging syndrome	NA	BeFree		Detail
<0.001	pancreatic carcinoma	NA	BeFree		Detail
<0.001	Renal interstitial fibrosis	NA	BeFree		Detail
<0.001	Thrombosis of renal vein	NA	BeFree		Detail
<0.001	Papillary thyroid carcinoma	NA	BeFree		Detail
0.002	Fibrosis, Liver	NA	BeFree		Detail
<0.001	Interstitial fibrosis	NA	BeFree		Detail
0.006	coronary stenosis	NA	BeFree,GAD,LHGDN		Detail
0.009	Dyslipidemias	NA	BeFree,GAD,LHGDN		Detail
0.007	Malignant neoplasm of lung	Plasminogen activator inhibitor-1 and susceptibility to lung cancer: a populatio...	BeFree,GAD	24955483	Detail
<0.001	age related macular degeneration	NA	BeFree		Detail
0.002	Acute Lung Injury	NA	GAD		Detail
0.002	Oxidative Stress	NA	GAD		Detail
<0.001	protein S deficiency	NA	BeFree		Detail
<0.001	Systemic Inflammatory Response Syndrome	NA	BeFree		Detail
0.019	Sepsis	NA	BeFree,GAD,LHGDN		Detail
<0.001	subendocardial myocardial infarction	NA	BeFree		Detail
<0.001	Coronary artery atheroma	NA	BeFree		Detail
0.003	Chronic Periodontitis	NA	BeFree,LHGDN		Detail
0.080	Pancreatitis, Acute Necrotizing	NA	BeFree,RGD		Detail
<0.001	5,10-Methylenetetrahydrofolate reductase deficiency	NA	BeFree		Detail
<0.001	Renal glomerular disease	NA	BeFree		Detail
<0.001	Endometrioma	NA	BeFree		Detail
<0.001	Atopic cataract	NA	BeFree		Detail
<0.001	Acute otitis media	NA	BeFree		Detail
<0.001	Impaired glucose tolerance	PAI-1 deficiency significantly reduced insulin resistance and glucose intoleranc...	BeFree	25552599	Detail
<0.001	Cancer of Head and Neck	NA	BeFree		Detail
<0.001	Conventional (Clear Cell) Renal Cell Carcinoma	NA	BeFree		Detail
<0.001	Solid tumour	NA	BeFree		Detail
<0.001	Adenocarcinoma of pancreas	NA	BeFree		Detail
0.001	cervix carcinoma	NA	BeFree		Detail
0.001	Obesity, Abdominal	NA	BeFree		Detail
<0.001	Lupus anticoagulant disorder	NA	BeFree		Detail
<0.001	Fibrous nodule	NA	BeFree		Detail
0.003	Restenosis	NA	BeFree,GAD		Detail
<0.001	Mural thrombus	NA	BeFree		Detail
<0.001	Platelet thrombus	NA	BeFree		Detail
<0.001	Senile Plaques	In contrary, PAI-1 expression increases during aging or Aβ deposition with its c...	BeFree	25454795	Detail
<0.001	Tumor necrosis	NA	BeFree		Detail
<0.001	anaplastic astrocytoma	NA	BeFree		Detail
<0.001	Proliferative retinopathy	NA	BeFree		Detail
<0.001	Anterior myocardial infarction	NA	BeFree		Detail
<0.001	Aortic aneurysm without mention of rupture NOS	NA	BeFree		Detail
<0.001	Dissection of aorta	NA	BeFree		Detail
0.003	Deep vein thrombosis of lower limb	PAI-1 4G/5G and MTHFR C677T polymorphisms increased the accuracy of two predicti...	BeFree	24715181	Detail
<0.001	Venous hypertension	NA	BeFree		Detail
0.002	Complications of Diabetes Mellitus	NA	GAD		Detail
<0.001	Deficiency of testosterone biosynthesis	NA	BeFree		Detail
<0.001	Precocious pubarche	NA	BeFree		Detail
<0.001	Organ dysfunction syndrome	NA	BeFree		Detail
<0.001	malignant mesothelioma	NA	BeFree		Detail
<0.001	Malignant neoplasm of pancreas	NA	BeFree		Detail
<0.001	Asthma attack	NA	BeFree		Detail
<0.001	Pulmonary lymphangioleiomyomatosis	NA	BeFree		Detail
<0.001	Ischemic cardiomyopathy	NA	BeFree		Detail
0.001	Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site	NA	BeFree		Detail
0.007	Malignant neoplasm of prostate	NA	BeFree,GAD		Detail
0.080	Endotoxemia	NA	RGD		Detail
<0.001	Recurrent acute otitis media	NA	BeFree		Detail
0.023	thrombophilia	NA	BeFree,GAD,LHGDN		Detail
<0.001	Non-alcoholic Fatty Liver Disease	Animal models of non-alcoholic fatty liver disease (NAFLD) suggest that an incre...	BeFree	24351080	Detail
<0.001	Idiopathic crescentic glomerulonephritis	NA	BeFree		Detail
0.003	Chronic Kidney Insufficiency	NA	BeFree,GAD		Detail
0.003	Osteoarthritis, Knee	NA	LHGDN		Detail
<0.001	lupus erythematosus	NA	BeFree		Detail
<0.001	Klinefelter's syndrome - male with more than two X chromosomes	NA	BeFree		Detail
<0.001	Non-obstructive reflux-associated chronic pyelonephritis (disorder)	NA	BeFree		Detail
0.001	endometrial carcinoma	NA	BeFree		Detail
<0.001	pricking of skin	NA	BeFree		Detail
0.001	Secondary malignant neoplasm of liver	Silencing of plasminogen activator inhibitor-1 suppresses colorectal cancer prog...	BeFree	26275833	Detail
<0.001	dementia	Our results show that plasma PAI-1 levels gradually increased as dementia progre...	BeFree	25304332	Detail
<0.001	Overweight	NA	BeFree		Detail
<0.001	acute pyelonephritis	NA	BeFree		Detail
0.003	Sleep Apnea, Obstructive	NA	BeFree,GAD		Detail
<0.001	Bilateral cataracts (disorder)	NA	BeFree		Detail
<0.001	Associated symptom	NA	BeFree		Detail
0.016	Metabolic syndrome X	The current study tried to investigate in parallel the association of PAI-1 acti...	BeFree,GAD	24695040	Detail
0.003	Pulmonary Thromboembolisms	NA	BeFree,GAD		Detail
<0.001	Atherosclerotic occlusive disease	NA	BeFree		Detail
0.002	Brain hemorrhage	NA	GAD		Detail
0.002	Menopause present (finding)	NA	GAD		Detail
0.004	Factor V Leiden mutation	The polymorphisms of FVL and FII should be screened in RM women, whereas PAI-1 s...	BeFree	24484533	Detail
0.004	Factor V Leiden mutation	In terms of subgroup analyses on co-existence of other thrombotic risk factors, ...	BeFree	25450536	Detail
0.002	Carcinogenesis	NA	BeFree		Detail
<0.001	hyperhomocysteinemia	NA	BeFree		Detail
0.002	prostate carcinoma	NA	BeFree		Detail
0.001	Activated Protein C Resistance	NA	BeFree		Detail
0.005	hepatopulmonary syndrome	NA	BeFree,GAD,LHGDN		Detail
0.001	Epithelial ovarian cancer	P21, GADD45 and PAI-1 expression were down-regulated in mutant OCCs.	BeFree	25958320	Detail
0.012	breast carcinoma	NA	BeFree		Detail
0.002	Carcinoma of lung	Plasminogen activator inhibitor-1 and susceptibility to lung cancer: a populatio...	BeFree	24955483	Detail
0.002	Secondary malignant neoplasm of lymph node	NA	BeFree		Detail
0.014	Pregnancy loss	NA	GAD		Detail
<0.001	Community acquired pneumonia	NA	BeFree		Detail
<0.001	Infection of ear	NA	BeFree		Detail
0.002	colon carcinoma	The biologic consequences of PAI-1 silencing in colon cancer cell lines and CRC ...	BeFree	26275833	Detail
0.005	stomach carcinoma	miR-30b may function as a novel tumor suppressor gene in gastric cancer by targe...	BeFree	25170877	Detail
<0.001	Carcinoma of bladder	NA	BeFree		Detail
<0.001	skin carcinoma	NA	BeFree		Detail
<0.001	Central neuroblastoma	NA	BeFree		Detail
<0.001	Dissecting aneurysm of the thoracic aorta	NA	BeFree		Detail
<0.001	Central Serous Chorioretinopathy	The prevalence of 4G/5G polymorphism of plasminogen activator inhibitor-1 (PAI-1...	BeFree	24446892	Detail
<0.001	Middle Cerebral Artery Occlusion	NA	BeFree		Detail
0.080	Infarction, Middle Cerebral Artery	NA	RGD		Detail
<0.001	cardiac event	NA	BeFree		Detail
<0.001	early pregnancy	NA	BeFree		Detail
<0.001	Acute Cerebrovascular Accidents	NA	BeFree		Detail
<0.001	Myasthenia Gravis, Autoimmune, Experimental	In an attempt to treat EAMG with an 18aa peptide derived from the PA system inhi...	BeFree	24423642	Detail
0.002	intracranial embolism	NA	GAD		Detail
<0.001	Dural Arteriovenous Fistula	NA	BeFree		Detail
<0.001	Helicobacter pylori infection	NA	BeFree		Detail
0.009	Pregnancy associated hypertension	NA	GAD		Detail
0.002	Blood Coagulation Disorders, Inherited	NA	GAD		Detail
<0.001	Arteriopathic disease	NA	BeFree		Detail
<0.001	Invasive breast carcinoma	NA	BeFree		Detail
<0.001	Testicular malignant germ cell tumor	NA	BeFree		Detail
0.002	Endothelial dysfunction	NA	BeFree		Detail
0.003	Budd-Chiari syndrome	NA	BeFree,LHGDN		Detail
<0.001	Muscle fibrosis	NA	BeFree		Detail
<0.001	Asthma chronic	NA	BeFree		Detail
<0.001	Cerebral Ischemia	NA	BeFree		Detail
0.008	ovarian neoplasm	NA	BeFree,LHGDN		Detail
<0.001	Vascular inflammations	NA	BeFree		Detail
0.014	Ischemic stroke	Plasminogen activator inhibitor-1 4G/5G polymorphism and ischemic stroke risk: a...	BeFree,GAD	24472072	Detail
0.014	Ischemic stroke	Global fibrinolytic activity, PAI-1 level, and 4G/5G polymorphism in Thai childr...	BeFree,GAD	25284719	Detail
0.004	Acute coronary syndrome	Healthy HDL inhibited thrombin-induced plasminogen activator inhibitor type 1 (P...	BeFree,GAD	25056722	Detail
0.004	Acute coronary syndrome	The -844 G>A PAI-1 polymorphism is associated with acute coronary syndrome in Me...	BeFree,GAD	25788758	Detail
<0.001	Venoocclusive disease	NA	BeFree		Detail
0.002	coronary restenosis	NA	GAD		Detail
<0.001	Macroangiopathy	NA	BeFree		Detail
0.001	Vascular occlusion	NA	BeFree		Detail
0.003	Invasive Ductal Breast Carcinoma	NA	BeFree,GAD		Detail
0.008	Malignant neoplasm of ovary	Inhibition of plasminogen activator inhibitor-1 is a potential therapeutic strat...	BeFree,GAD	25587663	Detail
0.003	Ductal Carcinoma	NA	LHGDN		Detail
<0.001	prothrombin gene mutation	NA	BeFree		Detail
<0.001	Mural thrombus of heart	NA	BeFree		Detail
0.003	sarcoma	NA	BeFree,LHGDN		Detail
<0.001	attention deficit hyperactivity disorder	NA	BeFree		Detail
<0.001	major depressive disorder	NA	BeFree		Detail
<0.001	Mild cognitive disorder	The mean levels of plasma PAI-1 in patients with MCI and AD patients were signif...	BeFree	25304332	Detail
<0.001	First myocardial infarction	Three hundred and fifty six patients with first myocardial infarction (MI) were ...	BeFree	23990179	Detail
<0.001	nonspecific interstitial pneumonia	NA	BeFree		Detail
<0.001	Chronic myeloproliferative disorder	Elevated levels of PAI-1 in MPN patients may result from its increased productio...	BeFree	24509338	Detail
<0.001	Peripheral arterial occlusive disease	NA	BeFree		Detail
<0.001	Epithelioma	NA	BeFree		Detail
<0.001	Conn Syndrome	NA	BeFree		Detail
<0.001	Cardiomyopathy, Familial Idiopathic	NA	BeFree		Detail
0.036	Mammary Neoplasms	NA	BeFree,GAD,LHGDN		Detail
<0.001	Angiogenic Switch	We conclude that the HIF-2α target gene PAI-1 favors the angiogenic switch in HC...	BeFree	25489981	Detail
<0.001	Hepatocarcinogenesis	NA	BeFree		Detail
<0.001	Tumor Angiogenesis	NA	BeFree		Detail
<0.001	Xenograft Model	NA	BeFree		Detail
0.011	colorectal cancer	Furthermore, unlike CEA and PAI-1, up-regulation of TRFM in pathological stages ...	BeFree,GAD	25216327	Detail
0.011	colorectal cancer	Silencing of plasminogen activator inhibitor-1 suppresses colorectal cancer prog...	BeFree,GAD	26275833	Detail
<0.001	brain edema	NA	BeFree		Detail
<0.001	Non-Malignant Ascites Adverse Event	NA	BeFree		Detail
<0.001	Chronic Kidney Diseases	NA	BeFree		Detail
0.002	Fibrinogen Adverse Event	NA	GAD		Detail
<0.001	tumor vasculature	NA	BeFree		Detail
<0.001	Aggressive periodontitis, generalized	NA	BeFree		Detail
0.001	Severe Sepsis	NA	BeFree		Detail
0.001	Idiopathic Pulmonary Fibrosis	NA	BeFree		Detail
0.002	ASPIRIN RESISTANCE	NA	GAD		Detail
<0.001	Fibrinolytic Defect	NA	BeFree		Detail
<0.001	THROMBOPHILIA DUE TO ACTIVATED PROTEIN C RESISTANCE (disorder)	NA	BeFree		Detail
0.012	Venous thromboembolism	NA	GAD		Detail
0.001	uterine corpus cancer	NA	BeFree		Detail
0.038	coronary artery disease	NA	BeFree,GAD,LHGDN		Detail
0.005	Precursor Cell Lymphoblastic Leukemia Lymphoma	NA	BeFree,GAD,LHGDN		Detail
0.011	liver carcinoma	HIF-2alpha-dependent PAI-1 induction contributes to angiogenesis in hepatocellul...	BeFree,GAD,LHGDN	25489981	Detail
<0.001	Idiopathic Interstitial Pneumonias	NA	BeFree		Detail
<0.001	Prothrombin G20210A mutation	NA	BeFree		Detail
<0.001	Hereditary protein S deficiency	NA	BeFree		Detail
<0.001	Allergic rhinitis (disorder)	NA	BeFree		Detail
0.001	Thrombotic Microangiopathies	NA	BeFree		Detail
<0.001	Infectious Otitis Media	NA	BeFree		Detail
0.002	Infection of amniotic sac and membranes, unspecified, unspecified trimester, not applicable or unspecified	NA	GAD		Detail
0.002	Recurrent pregnancy loss	NA	GAD		Detail
<0.001	Obesity, Visceral	NA	BeFree		Detail
<0.001	Plaque, Amyloid	In contrary, PAI-1 expression increases during aging or Aβ deposition with its c...	BeFree	25454795	Detail
0.080	Neointima	NA	RGD		Detail
<0.001	Idiopathic pulmonary arterial hypertension	NA	BeFree		Detail
0.004	Ischemic Cerebrovascular Accident	Plasminogen activator inhibitor-1 4G/5G polymorphism and ischemic stroke risk: a...	BeFree	24472072	Detail
0.004	Ischemic Cerebrovascular Accident	Global fibrinolytic activity, PAI-1 level, and 4G/5G polymorphism in Thai childr...	BeFree	25284719	Detail
<0.001	Homocysteinemia	NA	BeFree		Detail
<0.001	Reflux nephropathy (disorder)	NA	BeFree		Detail
0.002	granulomatosis with polyangiitis	NA	GAD		Detail
<0.001	Allergic disposition	NA	BeFree		Detail
0.005	Infection	NA	GAD		Detail
0.002	Insulin resistance syndrome	NA	BeFree		Detail
0.008	Spontaneous abortion	NA	GAD,LHGDN		Detail
0.005	Abortion, Habitual	NA	GAD		Detail
<0.001	acute pancreatitis	NA	BeFree		Detail
0.005	adenocarcinoma	NA	BeFree,LHGDN		Detail
<0.001	adenoma	NA	BeFree		Detail
<0.001	Adenovirus Infections	NA	BeFree		Detail
<0.001	Postoperative adhesion	NA	BeFree		Detail
0.002	Albuminuria	NA	GAD		Detail
0.006	Alzheimer's disease	Plasminogen activator inhibitor-1 as an early potential diagnostic marker for Al...	BeFree,GAD	25304332	Detail
0.006	Alzheimer's disease	Impacts of aging and amyloid-β deposition on plasminogen activators and plasmino...	BeFree,GAD	25454795	Detail
0.003	amyloidosis	NA	BeFree,GAD		Detail
0.005	amyotrophic lateral sclerosis	NA	GAD		Detail
<0.001	Anaplasia	NA	BeFree		Detail
0.005	Anemia, Sickle Cell	NA	BeFree,GAD		Detail
0.003	Aneurysm	NA	BeFree,GAD		Detail
0.003	Angina Pectoris	NA	LHGDN		Detail
0.003	Angina, Unstable	NA	BeFree,GAD		Detail
0.002	Anoxia	NA	GAD		Detail
<0.001	Anxiety Disorders	Using data from the borderline subscale of the Personality Assessment Inventory ...	BeFree	23979607	Detail
0.081	aortic aneurysm	NA	BeFree,RGD		Detail
0.008	arteriosclerosis	NA	BeFree		Detail
<0.001	arthritis	NA	BeFree		Detail
0.019	rheumatoid arthritis	NA	BeFree,GAD,LHGDN		Detail
0.107	asthma	NA	BeFree,GAD,LHGDN,RGD		Detail
<0.001	Astrocytoma	NA	BeFree		Detail
0.145	atherosclerosis	NA	BeFree,CTD_human,GAD,LHGDN		Detail
0.002	atrial fibrillation	NA	GAD		Detail
0.120	autistic disorder	NA	BeFree,CTD_human		Detail
0.002	Bacteremia	NA	GAD		Detail
<0.001	Bacterial Infections	NA	BeFree		Detail
0.125	Behcet Syndrome	NA	BeFree,CTD_human,GAD		Detail
0.002	beta thalassemia	NA	GAD		Detail
<0.001	biliary atresia	NA	BeFree		Detail
<0.001	Malignant neoplasm of urinary bladder	NA	BeFree		Detail
0.006	Blood Coagulation Disorders	Using a murine model of severe TBI, we found that ICH is reduced in tPA(-/-) and...	BeFree,GAD	25673638	Detail
<0.001	borderline personality disorder	NA	BeFree		Detail
<0.001	Brain Neoplasms	NA	BeFree		Detail
0.024	Malignant neoplasm of breast	NA	BeFree,GAD		Detail
0.003	bronchopulmonary dysplasia	NA	BeFree,GAD		Detail
0.001	Malignant tumor of colon	The biologic consequences of PAI-1 silencing in colon cancer cell lines and CRC ...	BeFree	26275833	Detail
0.001	Malignant neoplasm of endometrium	NA	BeFree		Detail
<0.001	Adenocarcinoma of prostate	NA	BeFree		Detail
<0.001	Noninfiltrating Intraductal Carcinoma	NA	BeFree		Detail
<0.001	Non-small cell lung carcinoma	NA	BeFree		Detail
0.001	renal cell carcinoma	NA	BeFree		Detail

Annotation

Annotations

Descrption	Source	Links
NA	DisGeNET	Detail
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This review provides an overview on the current knowledge on PAI-1 especially importance of PAI-1 le...	DisGeNET	Detail
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NA	DisGeNET	Detail
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NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
Furthermore, unlike CEA and PAI-1, up-regulation of TRFM in pathological stages I & II groups compar...	DisGeNET	Detail
Silencing of plasminogen activator inhibitor-1 suppresses colorectal cancer progression and liver me...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
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Our results show that plasma PAI-1 levels gradually increased as dementia progressed.	DisGeNET	Detail
Using data from the borderline subscale of the Personality Assessment Inventory Borderline Features ...	DisGeNET	Detail
Using data from the borderline subscale of the Personality Assessment Inventory Borderline Features ...	DisGeNET	Detail
NA	DisGeNET	Detail
Role of plasminogen activator inhibitor-1 in glucocorticoid-induced diabetes and osteopenia in mice.	DisGeNET	Detail
Role of plasminogen activator inhibitor-1 in glucocorticoid-induced diabetes and osteopenia in mice.	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
Patients with type 2 diabetes showed increased expression of PAI-1, indicative of reduced fibrinolys...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
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Association between plasminogen activator inhibitor-1 4G/5G gene polymorphism and immunoglobulin A n...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
Penile pseudomyogenic hemangioendothelioma/epithelioid sarcoma-like hemangioendothelioma with a nove...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
In conclusion, thrombo and fibro-genetic mechanisms of PAI-1 4G-4G and MTHFR 677TT, could have a rol...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
PAI-1 polymorphism was synergistic with hyperinsulinemia.	DisGeNET	Detail
PAI-1 deficiency significantly reduced insulin resistance and glucose intolerance but not hyperlipid...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
Hypertension is associated with increased expression of FABP3, FAS, FN1, IL1R2, LPL, SERPINE1, TGFB1...	DisGeNET	Detail
The presence of type 2 diabetes associated with 3.2-fold increased PAI-1 expression (adjusted p=0.03...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
Plasminogen activator inhibitor-1 in cigarette smoke exposure and influenza A virus infection-induce...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
Association of the plasminogen activator inhibitor-1 (PAI-1) Gene -675 4G/5G and -844 A/G promoter p...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
In conclusion, thrombo and fibro-genetic mechanisms of PAI-1 4G-4G and MTHFR 677TT, could have a rol...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
We found increased p53, PAI-1 and apoptosis in AECs, with accumulation of macrophages and neutrophil...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
Plasma PAI-1 level was higher in CRC patients with liver metastasis and correlated with liver metast...	DisGeNET	Detail
miR-30b may function as a novel tumor suppressor gene in gastric cancer by targeting PAI-1 and regul...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
In conclusion, the current study indicated that PAI-1 is involved in GC-induced glucose metabolism a...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
Elevated levels of PAI-1 in MPN patients may result from its increased production by elevated number...	DisGeNET	Detail
The association between plasminogen activator inhibitor type 1 (PAI-1) levels, PAI-1 4G/5G polymorph...	DisGeNET	Detail
We aimed to investigate the association of plasminogen activator inhibitor-1 (PAI-1) and tissue plas...	DisGeNET	Detail
PAI-1 plays a pivotal role in acute thrombotic events such as deep vein thrombosis (DVT) and myocard...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
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The aim of this work was to establish an association between the single-nucleotide polymorphisms (SN...	DisGeNET	Detail
The aim of this work was to establish an association between the single-nucleotide polymorphisms (SN...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
Inhibition of plasminogen activator inhibitor-1 is a potential therapeutic strategy in ovarian cance...	DisGeNET	Detail
P21, GADD45 and PAI-1 expression were down-regulated in mutant OCCs.	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
The 4G/4G polymorphism of the plasminogen activator inhibitor-1 (PAI-1) gene as an independent risk ...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
These observations indicate that increased PAI-1 expression promotes AEC apoptosis and exacerbates l...	DisGeNET	Detail
NA	DisGeNET	Detail
4G/5G polymorphism of plasminogen activator inhibitor-1 gene is associated with polycystic ovary syn...	DisGeNET	Detail
Concentration of PAI-1:Ag was increased in patients with essential thrombocythemia and polycythemia ...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
Hereditary hypofibrinolysis, which is mediated by 4G/4G homozygosity for the PAI-1 gene, is an indep...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
The biological effects of PAI-1 extend far beyond thrombosis including its critical role in fibrotic...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
In our study, the FII G20210A and the MTHFR C677T mutations resulted significantly higher in patient...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
Expression levels of other TGF-β-regulated genes, including SERPINE1 and CTGF, declined (P = 0.049 a...	DisGeNET	Detail
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Pai-1 gene variants and COC use are associated with stroke risk: a case-control study in the Han Chi...	DisGeNET	Detail
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Concentration of PAI-1:Ag was increased in patients with essential thrombocythemia and polycythemia ...	DisGeNET	Detail
Association between the plasminogen activator inhibitor-1 4G/5G polymorphism and risk of venous thro...	DisGeNET	Detail
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ATM activation (pATM(Ser1981)) increased 4-fold in the tubulointerstitial region of the unilateral u...	DisGeNET	Detail
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The inactivation of plasminogen activator inhibitor-1 (PAI-1) has been shown to exert beneficial eff...	DisGeNET	Detail
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Plasminogen activator inhibitor-1 in cigarette smoke exposure and influenza A virus infection-induce...	DisGeNET	Detail
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PAI-1 4G/5G and MTHFR C677T polymorphisms increased the accuracy of two prediction scores for the ri...	DisGeNET	Detail
PAI-1 plays a pivotal role in acute thrombotic events such as deep vein thrombosis (DVT) and myocard...	DisGeNET	Detail
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Relation of PAI-1 and TPA genes polymorphisms to acute myocardial infarction and its outcomes in Egy...	DisGeNET	Detail
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In conclusion, thrombo and fibro-genetic mechanisms of PAI-1 4G-4G and MTHFR 677TT, could have a rol...	DisGeNET	Detail
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MiR-10a and miR-181c regulate collagen type I generation in hypertrophic scars by targeting PAI-1 an...	DisGeNET	Detail
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Although FOSB-rearranged EH do not show significant morphologic overlap with SERPINE1-FOSB fusion-po...	DisGeNET	Detail
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Interestingly, expression of PAI-1 was increased in ovarian clear cell carcinoma compared with that ...	DisGeNET	Detail
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Plasminogen activator inhibitor-1 and susceptibility to lung cancer: a population genetics perspecti...	DisGeNET	Detail
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PAI-1 deficiency significantly reduced insulin resistance and glucose intolerance but not hyperlipid...	DisGeNET	Detail
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In contrary, PAI-1 expression increases during aging or Aβ deposition with its clusters surrounding ...	DisGeNET	Detail
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PAI-1 4G/5G and MTHFR C677T polymorphisms increased the accuracy of two prediction scores for the ri...	DisGeNET	Detail
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Animal models of non-alcoholic fatty liver disease (NAFLD) suggest that an increased translocation o...	DisGeNET	Detail
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Silencing of plasminogen activator inhibitor-1 suppresses colorectal cancer progression and liver me...	DisGeNET	Detail
Our results show that plasma PAI-1 levels gradually increased as dementia progressed.	DisGeNET	Detail
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The current study tried to investigate in parallel the association of PAI-1 activity with the PAI-1 ...	DisGeNET	Detail
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The polymorphisms of FVL and FII should be screened in RM women, whereas PAI-1 seems to be weakly as...	DisGeNET	Detail
In terms of subgroup analyses on co-existence of other thrombotic risk factors, the PAI-1 4G/5G poly...	DisGeNET	Detail
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P21, GADD45 and PAI-1 expression were down-regulated in mutant OCCs.	DisGeNET	Detail
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Plasminogen activator inhibitor-1 and susceptibility to lung cancer: a population genetics perspecti...	DisGeNET	Detail
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The biologic consequences of PAI-1 silencing in colon cancer cell lines and CRC bearing nude mice we...	DisGeNET	Detail
miR-30b may function as a novel tumor suppressor gene in gastric cancer by targeting PAI-1 and regul...	DisGeNET	Detail
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The prevalence of 4G/5G polymorphism of plasminogen activator inhibitor-1 (PAI-1) gene in central se...	DisGeNET	Detail
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In an attempt to treat EAMG with an 18aa peptide derived from the PA system inhibitor (PAI-1), desig...	DisGeNET	Detail
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Plasminogen activator inhibitor-1 4G/5G polymorphism and ischemic stroke risk: a meta-analysis in Ch...	DisGeNET	Detail
Global fibrinolytic activity, PAI-1 level, and 4G/5G polymorphism in Thai children with arterial isc...	DisGeNET	Detail
Healthy HDL inhibited thrombin-induced plasminogen activator inhibitor type 1 (PAI-1) expression, wh...	DisGeNET	Detail
The -844 G>A PAI-1 polymorphism is associated with acute coronary syndrome in Mexican population.	DisGeNET	Detail
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Inhibition of plasminogen activator inhibitor-1 is a potential therapeutic strategy in ovarian cance...	DisGeNET	Detail
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The mean levels of plasma PAI-1 in patients with MCI and AD patients were significantly higher than ...	DisGeNET	Detail
Three hundred and fifty six patients with first myocardial infarction (MI) were followed up during a...	DisGeNET	Detail
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Elevated levels of PAI-1 in MPN patients may result from its increased production by elevated number...	DisGeNET	Detail
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We conclude that the HIF-2α target gene PAI-1 favors the angiogenic switch in HCC.	DisGeNET	Detail
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Furthermore, unlike CEA and PAI-1, up-regulation of TRFM in pathological stages I & II groups compar...	DisGeNET	Detail
Silencing of plasminogen activator inhibitor-1 suppresses colorectal cancer progression and liver me...	DisGeNET	Detail
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HIF-2alpha-dependent PAI-1 induction contributes to angiogenesis in hepatocellular carcinoma.	DisGeNET	Detail
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In contrary, PAI-1 expression increases during aging or Aβ deposition with its clusters surrounding ...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
Plasminogen activator inhibitor-1 4G/5G polymorphism and ischemic stroke risk: a meta-analysis in Ch...	DisGeNET	Detail
Global fibrinolytic activity, PAI-1 level, and 4G/5G polymorphism in Thai children with arterial isc...	DisGeNET	Detail
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Plasminogen activator inhibitor-1 as an early potential diagnostic marker for Alzheimer's disease.	DisGeNET	Detail
Impacts of aging and amyloid-β deposition on plasminogen activators and plasminogen activator inhibi...	DisGeNET	Detail
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Using data from the borderline subscale of the Personality Assessment Inventory Borderline Features ...	DisGeNET	Detail
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Using a murine model of severe TBI, we found that ICH is reduced in tPA(-/-) and uPA(-/-) mice but i...	DisGeNET	Detail
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The biologic consequences of PAI-1 silencing in colon cancer cell lines and CRC bearing nude mice we...	DisGeNET	Detail
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Overlapped Transcript Coordinates

Gene	Transcript ID	Exon Number	Chromosome	Start	Stop	Type	Amino Mutation	Transcript Position	Links

Overlapped Transcript

Gene	Transcript ID	Chromosome	Start	Stop	Links

Gene: -
dbSNP: rs17886084 dbSNP
Genome: hg19
Position: chr7:100,770,385-100,782,528
Variant Type: snv

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