Thrombotic Microangiopathies
Information
- Disease name
- Thrombotic Microangiopathies
- Disease ID
- Description
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
| Genes | Mutation | Description | Source | Links |
|---|
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT04570397 | Active, not recruiting | Phase 3 | Ravulizumab and COVID-19 | December 18, 2020 | November 2023 |
| NCT03384693 | Completed | Phase 2 | Defibrotide TMA Prophylaxis Pilot Trial | May 1, 2018 | July 31, 2020 |
| NCT03252925 | Completed | Phase 3 | A Safety and Efficacy Study of NAC in Patients With TA-TMA | November 1, 2017 | October 1, 2021 |
| NCT02134171 | Completed | N/A | Early Predictive Factors of Cardiac and Cerebral Involvement in TMA | June 10, 2014 | July 30, 2017 |
| NCT03518203 | Completed | Phase 2 | Eculizumab to Treat Thrombotic Microangiopathy/Atypical Hemolytic Uremic Syndrome -Associated Multiple Organ Dysfunction Syndrome in Hematopoietic Stem Cell Transplant Recipients | August 3, 2018 | June 1, 2022 |
| NCT02222545 | Completed | Phase 2 | Safety and Efficacy Study of OMS721 in Patients With Thrombotic Microangiopathies | November 2, 2014 | August 11, 2020 |
| NCT05996679 | Not yet recruiting | Automated Surveillance, Alert, and Rapid Diagnosis of Thrombotic Microangiopathies: the ASARD-TMA Study | October 1, 2023 | October 1, 2025 | |
| NCT06291025 | Not yet recruiting | N/A | Efficacy and Safety of Immunosuppression, Caplacizumab and Plasma Infusion Without Therapeutic Plasma Exchange in Immune-mediated Thrombotic Thrombocytopenic Purpura: Multicentric Non-inferiority Single-arm Study | April 1, 2024 | August 1, 2026 |
| NCT05702996 | Not yet recruiting | Phase 3 | Multicenter, Uncontrolled Pilot Study Evaluating the Efficacy of Eculizumab in the Treatment of Gemcitabine-induced Thrombotic Microangiopathies | March 2023 | September 2025 |
| NCT06182410 | Not yet recruiting | Phase 2 | Defibrotide Prophylaxis of Transplant Associated-Thrombotic Microangiopathy for Neuroblastoma | June 1, 2024 | March 31, 2027 |
| NCT06291415 | Recruiting | Phase 1 | The Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of HMPL-523 in Adult Subjects With Immune Thrombocytopenia (ITP) | April 2, 2024 | November 2026 |
| NCT04098445 | Recruiting | TRANSPIRE: Lung Injury in a Longitudinal Cohort of Pediatric HSCT Patients | September 8, 2021 | September 2036 | |
| NCT04745195 | Recruiting | Complement Prospective Evaluation of Thrombotic Microangiopathy on Endothelium | August 12, 2021 | August 31, 2024 | |
| NCT04784455 | Recruiting | Phase 3 | Nomacopan (rVA576) in Transplant Associated Thrombotic Microangiopathy | February 1, 2021 | December 2025 |
| NCT05634928 | Recruiting | Construction of a Database for TMA | December 1, 2022 | November 30, 2028 | |
| NCT05855083 | Recruiting | Phase 2 | Efficacy and Safety Study of Narsoplimab in Pediatric Patients With High-Risk Hematopoietic Stem Cell Transplant TMA | May 1, 2023 | December 2025 |
| NCT06098378 | Recruiting | Study of Patients With Thrombotic Microangiopathy Associated With Mitomycin C, Treated or Not With Eculizumab | June 7, 2023 | June 7, 2025 | |
| NCT06102694 | Recruiting | Identification of Plasma Biomarkers for Early Diagnosis of Transplant-associated Thrombotic Microangiopathy | November 16, 2023 | December 2025 | |
| NCT02373267 | Unknown status | Screening of TMA Patients für ADAMTS13 Activity (Adamscreen) | March 2015 | February 2019 | |
| NCT03605511 | Unknown status | TTP and aHUS in Complicated Pregnancies | September 21, 2018 | March 14, 2020 | |
| NCT03205995 | Unknown status | Phase 3 | Safety and Efficacy Study of OMS721 in Patients With Atypical Hemolytic Uremic Syndrome | February 23, 2017 | February 2020 |
| NCT04970004 | Withdrawn | Study in Adult and Pediatric Patients With HSCT-TMA | July 12, 2021 | April 1, 2022 |
- MeSH unique ID (MeSH (Medical Subject Headings))
- D057049