Annotation Detail
Information
- Associated Genes
- SERPINE1
- Associated Variants
-
SERPINE1 MUTATION
SERPINE1 MUTATION - Associated Disease
- ureteral obstruction
- Source Database
- DisGeNET
- Description
- ATM activation (pATM(Ser1981)) increased 4-fold in the tubulointerstitial region of the unilateral ureteral obstruction-injured kidney in mice correlating with SMAD3 and p53(Ser15) phosphorylation and elevated levels of p22(phox) subunit of the NADPH oxidases (NOXs), and fibrotic markers, plasminogen activator inhibitor-1 (PAI-1), and fibronectin, when compared to contralateral (contra) or sham controls.
- Pubmed
- 25480384
- Section of the abstract supporting the evidence
- ALL_TEXT_1/3
- Number of the section of the abstract supporting the evidence
- 1
- Number of the sentence supporting the evidence
- 3
- Original source reporting the Gene Disease association
- BeFree,RGD
- DisGENET score for the Gene Disease association
- 0.0802714418720803
Drugs