chr11:2181009:> Detail (hg19)

Information

Genome

Assembly Position
hg19 chr11:2,181,009-2,182,451
hg38 chr11:2,159,779-2,161,221 

HGVS

Type Transcript Protein
Summary

MGeND

Clinical significance
Variant entry
GWAS entry
Disease area statistics Show details

Frequency

[No Data.]

Prediction

[No Data.]

ClinVar

Clinical Significance
Review star [No Data.]
Show details
Links
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
[No Data.]
CIViC
[No Data.]
DisGeNET
Score Disease name Description Source Pubmed Links
<0.001 renal cell carcinoma NA BeFree Detail
0.120 hypertrophic cardiomyopathy NA BeFree,CTD_human Detail
0.003 Carotid Artery Diseases NA LHGDN Detail
<0.001 carotid stenosis NA BeFree Detail
0.004 celiac disease NA BeFree,GAD Detail
<0.001 cerebellar ataxia NA BeFree Detail
<0.001 cerebral infarction NA BeFree Detail
0.001 Malignant tumor of cervix NA BeFree Detail
<0.001 Primary biliary cirrhosis NA BeFree Detail
0.003 cholelithiasis NA BeFree,GAD Detail
<0.001 cholera NA BeFree Detail
<0.001 cholestasis NA BeFree Detail
<0.001 chondrosarcoma NA BeFree Detail
<0.001 Chorea NA BeFree Detail
<0.001 ulcerative colitis NA BeFree Detail
<0.001 Colonic Polyps NA BeFree Detail
0.011 colorectal carcinoma Body size, physical activity, early-life energy restriction, and associations wi... BeFree 24972776 Detail
0.011 colorectal carcinoma Body size, physical activity, genetic variants in the insulin-like growth factor... BeFree 26025909 Detail
<0.001 Colorectal Neoplasms We investigated body size, physical activity, and early-life energy restriction ... BeFree 24972776 Detail
0.011 Coronary Arteriosclerosis The mechanistic effects of intravenous glucose, insulin and potassium (GIK) in c... BeFree 25135348 Detail
0.012 Coronary heart disease NA BeFree Detail
<0.001 Crohn Disease NA BeFree Detail
0.002 cryptorchidism NA BeFree Detail
0.004 cystic fibrosis Glucose derangements in CF seem to start from early infancy and, even when the p... BeFree 25336504 Detail
0.004 Presenile dementia Long-acting intranasal insulin detemir improves cognition for adults with mild c... BeFree 25374101 Detail
<0.001 Dementia, Vascular NA BeFree Detail
0.002 Mental Depression NA BeFree Detail
0.001 depressive disorder NA BeFree Detail
<0.001 lipoatrophic diabetes mellitus NA BeFree Detail
0.123 Hyperproinsulinemia These mutant proinsulin proteins accumulate in the endoplasmic reticulum (ER) an... BeFree 20034470 Detail
0.002 Diabetic Angiopathies NA GAD Detail
<0.001 diabetic cataract NA BeFree Detail
0.124 diabetic ketoacidosis NA BeFree,CTD_human Detail
0.132 Diabetic Nephropathy To follow-up on the GWAS, tag SNPs across PFKFB2 were genotyped in American Indi... BeFree,CTD_human,GAD 25662186 Detail
<0.001 Diabetic Neuropathies NA BeFree Detail
0.005 diabetic retinopathy Numerous reports suggest prominent vasoprotective effects of insulin growth fact... BeFree 25525174 Detail
<0.001 diarrhea NA BeFree Detail
<0.001 duodenal ulcer NA BeFree Detail
0.004 Dwarfism NA BeFree Detail
<0.001 Pituitary dwarfism NA BeFree Detail
<0.001 Eating Disorders NA BeFree Detail
<0.001 eclampsia The mechanisms may include the following pathways: [TGFB1 or TNFA]-[IL1B]-[pre-e... BeFree 25879409 Detail
0.120 Edema NA CTD_human Detail
<0.001 Experimental Autoimmune Encephalomyelitis NA BeFree Detail
<0.001 Endocrine System Diseases NA BeFree Detail
<0.001 endometriosis NA BeFree Detail
<0.001 Enterovirus Infections NA BeFree Detail
<0.001 epidermodysplasia verruciformis NA BeFree Detail
<0.001 epilepsy NA BeFree Detail
<0.001 Epilepsies, Myoclonic NA BeFree Detail
<0.001 Epilepsy, Temporal Lobe We hypothesized that functional polymorphisms in the insulin pathway genes INSR,... BeFree 25458098 Detail
<0.001 Esophageal Neoplasms NA BeFree Detail
<0.001 External exotoses Maximal insulin response following arginine challenge was also significantly att... BeFree 25541963 Detail
<0.001 hereditary multiple exostoses We hypothesized that loss of function of EXT1 or EXT2 in subjects with hereditar... BeFree 25541963 Detail
<0.001 Failure to Thrive NA BeFree Detail
0.125 Fatty Liver DBC1 KO mice fed a high-fat diet, although obese, remained insulin sensitive, ha... BeFree,CTD_human 25053585 Detail
0.125 Fatty Liver Insulin resistance and liver steatosis in chronic hepatitis C infection genotype... BeFree,CTD_human 25386071 Detail
0.125 Fatty Liver The present study clearly demonstrated that leptin improve fatty liver independe... BeFree,CTD_human 25415231 Detail
<0.001 fetal alcohol syndrome NA BeFree Detail
<0.001 Flushing NA BeFree Detail
<0.001 Friedreich ataxia Fasting glucose, fasting insulin and random HbA1C were obtained in 158 patients ... BeFree 24819921 Detail
0.002 gallbladder neoplasm NA GAD Detail
<0.001 Giant Cell Tumors NA BeFree Detail
<0.001 Gingival Diseases Insulin Response Genes in Different Stages of Periodontal Disease. BeFree 25924856 Detail
<0.001 gingivitis The mRNA expression patterns of genes that are associated with insulin response ... BeFree 25924856 Detail
0.001 glioblastoma NA BeFree Detail
0.002 Glioma NA BeFree Detail
<0.001 glomerulonephritis NA BeFree Detail
0.001 IgA glomerulonephritis NA BeFree Detail
<0.001 Glycogen storage disease type II NA BeFree Detail
<0.001 goiter Insulin resistance is a recently investigated risk factor, and the risk of goitr... BeFree 25047201 Detail
0.005 Graves Disease NA BeFree,GAD Detail
<0.001 Hamartoma Syndrome, Multiple NA BeFree Detail
<0.001 Sensorineural Hearing Loss (disorder) NA BeFree Detail
0.120 cardiac arrest NA CTD_human Detail
0.001 Heart Diseases NA BeFree Detail
0.121 Heart failure NA BeFree,CTD_human Detail
0.001 congestive heart failure NA BeFree Detail
<0.001 Atrial Septal Defects NA BeFree Detail
0.001 Helminthiasis NA BeFree Detail
<0.001 hemochromatosis NA BeFree Detail
0.120 hepatitis NA BeFree,CTD_human Detail
<0.001 hepatitis A NA BeFree Detail
0.002 hepatitis B Although the involvement of insulin-like signaling in cancer has been well docum... BeFree 24758241 Detail
0.002 hepatitis B The baseline characteristics were: 73% men, 17% coinfected with hepatitis C viru... BeFree 25185137 Detail
<0.001 Hepatitis, Chronic NA BeFree Detail
0.006 hepatitis C The baseline characteristics were: 73% men, 17% coinfected with hepatitis C viru... BeFree 25185137 Detail
0.006 hepatitis C To evaluate the expression of different insulin-like growth factor (IGF)-1 mRNA ... BeFree 25852271 Detail
<0.001 Herpes Simplex Infections NA BeFree Detail
0.002 Hirsutism NA GAD Detail
0.002 HIV Infections NA BeFree Detail
<0.001 Huntington disease Insulin and IGF-1 improve mitochondrial function in a PI-3K/Akt-dependent manner... BeFree 24992836 Detail
<0.001 Hydrocephalus, Normal Pressure NA BeFree Detail
<0.001 Hyperaldosteronism NA BeFree Detail
0.004 Hypercholesterolemia NA BeFree,LHGDN Detail
<0.001 Hypercholesterolemia, Familial NA BeFree Detail
0.274 hyperglycemia Gestational diabetes mellitus (GDM) is recognized as an imbalance between insuli... BeFree,CTD_human,CTD_mouse 25036896 Detail
0.274 hyperglycemia Thus, impairment of insulin secretion leads to hyperglycemia and eventually caus... BeFree,CTD_human,CTD_mouse 25084624 Detail
0.274 hyperglycemia Chronic hyperglycaemia is associated with a dramatic reduction in insulin-positi... BeFree,CTD_human,CTD_mouse 25145789 Detail
0.274 hyperglycemia Progressive gain of beta-cell function occurs over 7 months, as measured by gluc... BeFree,CTD_human,CTD_mouse 25402613 Detail
0.274 hyperglycemia These results indicate that high AR expression in the context of hyperglycemia a... BeFree,CTD_human,CTD_mouse 25541468 Detail
0.274 hyperglycemia Diabetes mellitus (DM) is characterized by hyperglycemia, associated to a lack o... BeFree,CTD_human,CTD_mouse 25562150 Detail
0.274 hyperglycemia Our results indicated the considerably aberrant MAPK signaling in both insulin-s... BeFree,CTD_human,CTD_mouse 25758573 Detail
0.274 hyperglycemia Insulin gene therapy, which has shown great efficacy in correcting hyperglycemia... BeFree,CTD_human,CTD_mouse 25894126 Detail
0.274 hyperglycemia Hyperglycemia in HNF-1α pregnancies is easily managed with current insulin proto... BeFree,CTD_human,CTD_mouse 25935773 Detail
<0.001 Hyperglycemic Hyperosmolar Nonketotic Coma NA BeFree Detail
0.193 hyperinsulinism Hyperinsulinemia initially presented in obese rats at 2 months (10.5 ± 0.7 μg/L ... BeFree,CTD_human,GAD,LHGDN 24477469 Detail
0.193 hyperinsulinism Bioactives of Artemisia dracunculus L. (termed PMI 5011) have been shown to impr... BeFree,CTD_human,GAD,LHGDN 24521217 Detail
0.193 hyperinsulinism Moreover, expression of human apoB in fat-fed mice was associated with 32% (p = ... BeFree,CTD_human,GAD,LHGDN 24673444 Detail
0.193 hyperinsulinism ACE genotype and salt status do not impact on insulin sensitivity through change... BeFree,CTD_human,GAD,LHGDN 25154650 Detail
0.193 hyperinsulinism PE cells co-cultured with islet cells or islet cell-derived conditioned medium (... BeFree,CTD_human,GAD,LHGDN 25173880 Detail
0.193 hyperinsulinism In diabetes, energy excess and prolonged hyperinsulinemia suppress muscle and ad... BeFree,CTD_human,GAD,LHGDN 25215442 Detail
0.193 hyperinsulinism A gene trap insertion in Alms1 on the insulin sensitive C57BL6/Ei genetic backgr... BeFree,CTD_human,GAD,LHGDN 25299671 Detail
0.193 hyperinsulinism The hepatic iron content, serum iron parameters, and expressions of TFRs and IRP... BeFree,CTD_human,GAD,LHGDN 25385842 Detail
0.193 hyperinsulinism Insulin production and secretion appeared to be inhibited, suppressing the devel... BeFree,CTD_human,GAD,LHGDN 25473963 Detail
0.193 hyperinsulinism Thiazolidinediones (TZDs), a class of antidiabetic drugs, act as insulin sensiti... BeFree,CTD_human,GAD,LHGDN 25521362 Detail
0.193 hyperinsulinism In addition, anandamide has been shown to stimulate insulin secretion in vitro, ... BeFree,CTD_human,GAD,LHGDN 25855974 Detail
0.120 Hyperkalemia NA CTD_human Detail
0.003 Hyperlipidemia Insulin resistance, obesity, and hyperlipidemia (high lipid levels in the blood)... BeFree 24944010 Detail
0.003 Hyperlipidemia, Familial Combined NA BeFree Detail
<0.001 Hyperlipoproteinemias NA BeFree Detail
<0.001 hyperlipoproteinemia type III NA BeFree Detail
<0.001 hyperlipoproteinemia type IV NA BeFree Detail
<0.001 Hypernatremia NA BeFree Detail
<0.001 hyperparathyroidism NA BeFree Detail
0.001 Hyperphagia NA BeFree Detail
<0.001 hyperprolactinemia NA BeFree Detail
0.234 Hypertensive disease Gβ3-deficient mice were normal as judged by body weight gain by age or by feedin... BeFree,CTD_human,LHGDN,RGD 25093805 Detail
0.234 Hypertensive disease This phenomenon, which may impair insulin secretion, has been suggested to be a ... BeFree,CTD_human,LHGDN,RGD 25201287 Detail
0.234 Hypertensive disease Preserved Na/HCO3 cotransporter sensitivity to insulin may promote hypertension ... BeFree,CTD_human,LHGDN,RGD 25354240 Detail
<0.001 hyperthyroidism NA BeFree Detail
0.123 Hypertriglyceridemia NA CTD_human,LHGDN Detail
0.168 hypoglycemia Congenital hyperinsulinism (CHI) is a rare metabolic disease characterized by in... BeFree,CTD_human,LHGDN 24756053 Detail
0.168 hypoglycemia Congenital hyperinsulinemic hypoglycemia (HI) is a heterogeneous genetic disorde... BeFree,CTD_human,LHGDN 25117148 Detail
0.168 hypoglycemia Of note, 40% of people with HNF1A-MODY and medical treatment were receiving insu... BeFree,CTD_human,LHGDN 25483937 Detail
0.168 hypoglycemia Loss-of-function abnormalities in cardiac Kir2.1 currents can lead to the long Q... BeFree,CTD_human,LHGDN 25727015 Detail
0.168 hypoglycemia Both cases had normal levels of fasting plasma glucose (FPG), fasting hyperinsul... BeFree,CTD_human,LHGDN 25753915 Detail
0.168 hypoglycemia Insulinomas are β-cell tumors that cause hypoglycemia through inappropriate secr... BeFree,CTD_human,LHGDN 26116696 Detail
0.168 hypoglycemia Congenital hyperinsulinism (CHI) is a severe heterogeneous disorder due to dysre... BeFree,CTD_human,LHGDN 26162674 Detail
0.168 hypoglycemia Insulin secretion becomes inappropriate for the level of blood glucose leading t... BeFree,CTD_human,LHGDN 26210630 Detail
0.120 hypokalemia NA CTD_human Detail
0.120 Hypotension NA CTD_human Detail
0.001 hypothyroidism NA BeFree Detail
<0.001 Immunologic Deficiency Syndromes NA BeFree Detail
0.001 Immune System Diseases NA BeFree Detail
<0.001 Neonatal disorder NA BeFree Detail
<0.001 male infertility NA BeFree Detail
<0.001 influenza NA BeFree Detail
0.137 Insulin resistance NA CTD_human,GAD Detail
0.019 insulinoma No patient was treated with insulin or had an insulinoma. BeFree 24111525 Detail
0.019 insulinoma In the 60-year-old female proband, hyperinsulinaemic hypoglycaemia (blood glucos... BeFree 24890200 Detail
0.019 insulinoma Examples of β-cell autoantigens are insulin, glutamic acid decarboxylase, tyrosi... BeFree 24993340 Detail
0.019 insulinoma Overexpression of angiotensin II type 2 receptor promotes apoptosis and impairs ... BeFree 25430897 Detail
0.019 insulinoma Characterization of the in vitro dynamics of insulin secretion by perifused frag... BeFree 26116696 Detail
<0.001 intermittent explosive disorder NA BeFree Detail
0.001 ischemia In our study, BMSCs were modified with insulin-like growth factor-1 (IGF-1) gene... BeFree 25767192 Detail
<0.001 Kearns-Sayre syndrome NA BeFree Detail
<0.001 Keloid NA BeFree Detail
0.012 Kidney Diseases In humans, inactivating mutations in GLUT2 cause Fanconi-Bickel syndrome, which ... BeFree 25421524 Detail
0.007 Kidney Failure, Chronic NA BeFree,GAD Detail
<0.001 Polycystic Kidney Diseases NA BeFree Detail
<0.001 Klinefelter syndrome NA BeFree Detail
0.002 Fibroid Tumor NA BeFree Detail
<0.001 leiomyosarcoma As G protein estrogen receptor 1 (GPER1) mediates rapid cell responses to estrog... BeFree 25012984 Detail
<0.001 leukemia NA BeFree Detail
<0.001 chronic lymphocytic leukemia Insulin growth factor 1 receptor expression is associated with NOTCH1 mutation, ... BeFree 25786252 Detail
<0.001 Acute lymphocytic leukemia NA BeFree Detail
<0.001 Leukemia, Myelocytic, Acute NA BeFree Detail
<0.001 Myeloid Leukemia, Chronic NA BeFree Detail
<0.001 Precursor B-Cell Lymphoblastic Leukemia-Lymphoma NA BeFree Detail
0.003 lipodystrophy NA BeFree Detail
<0.001 Hyperlipoproteinemia Type I NA BeFree Detail
<0.001 liposarcoma NA BeFree Detail
0.005 liver cirrhosis NA BeFree,LHGDN Detail
0.002 Liver diseases NA BeFree Detail
<0.001 Alcoholic Liver Diseases NA BeFree Detail
0.013 Liver neoplasms In addition, recent study demonstrates AFB1 positively regulates type I insulin-... BeFree,GAD 25820822 Detail
<0.001 Chronic Obstructive Airway Disease Furthermore, the investigation of extracellular matrix-related genes showed that... BeFree 25119290 Detail
<0.001 Chronic Obstructive Airway Disease Insulin resistance (HOMA-IR) and glomerular filtration rate (GFR) were similar b... BeFree 25785739 Detail
<0.001 Lupus Erythematosus, Systemic NA BeFree Detail
<0.001 lymphocytic choriomeningitis NA BeFree Detail
<0.001 lymphoma NA BeFree Detail
<0.001 Lymphoma, Non-Hodgkin NA BeFree Detail
0.001 lymphopenia NA BeFree Detail
<0.001 Machado-Joseph disease NA BeFree Detail
<0.001 Malabsorption Syndrome NA BeFree Detail
0.167 Metabolic syndrome X Association between rs146052672 variant and MetS occurred independently of T2D, ... BeFree 23512162 Detail
<0.001 malaria NA BeFree Detail
<0.001 Malignant hyperpyrexia due to anesthesia NA BeFree Detail
0.003 Malignant neoplasm of stomach To study the expression of insulin-like growth factor binding proteins (IGFBPs) ... BeFree 25081695 Detail
0.003 Malignant neoplasm of stomach Here, we reported significantly higher levels of serum insulin-like growth facto... BeFree 25596089 Detail
0.001 medulloblastoma NA BeFree Detail
0.003 melanoma NA BeFree Detail
0.120 Memory Disorders NA CTD_human Detail
<0.001 multiple endocrine neoplasia type 1 NA BeFree Detail
<0.001 meningioma NA BeFree Detail
<0.001 premature menopause NA BeFree Detail
<0.001 Mental Retardation NA BeFree Detail
<0.001 Mesothelioma NA BeFree Detail
0.131 Metabolic Diseases This review discusses the role of NO in regulating adiposity and insulin sensiti... BeFree,CTD_human 24878261 Detail
0.131 Metabolic Diseases The present review focuses on the role of aquaglyceroporins and caveolins on lip... BeFree,CTD_human 25008241 Detail
0.131 Metabolic Diseases Type 1 diabetes (T1D) is a metabolic disease that results from the autoimmune at... BeFree,CTD_human 25604067 Detail
0.131 Metabolic Diseases However, the role of adipocytes in linking energy metabolic disorders with insul... BeFree,CTD_human 25743104 Detail
0.131 Metabolic Diseases Excessive secretion of the growth hormone (GH) leads to hepatic secretion of ins... BeFree,CTD_human 25923102 Detail
0.131 Metabolic Diseases Results of this study demonstrate the dependence of insulin-like growth binding ... BeFree,CTD_human 25960008 Detail
<0.001 Microangiopathy, Diabetic NA BeFree Detail
<0.001 Mild Mental Retardation NA BeFree Detail
<0.001 Monosomy NA BeFree Detail
0.003 multiple myeloma In this study, we examined changes in gene expression profile in human mesenchym... BeFree 24410591 Detail
<0.001 multiple sclerosis The serum levels of numerous cytokines (IL-1β, IL-12, IL-6, TNF-α, IFN-γ, IL-4, ... BeFree 25173940 Detail
<0.001 mumps NA BeFree Detail
0.002 muscular atrophy NA BeFree Detail
<0.001 spinal muscular atrophy In this study, we evaluated the efficacy of intravenous administration of a reco... BeFree 24814151 Detail
<0.001 spinal muscular atrophy Recent evidence of IGF-1 axis alteration in spinal muscular atrophy (SMA), a ver... BeFree 26311784 Detail
0.120 myopathy NA BeFree,CTD_human Detail
<0.001 muscular dystrophy NA BeFree Detail
<0.001 myasthenia gravis NA BeFree Detail
<0.001 Myelodysplasia NA BeFree Detail
0.003 myocardial infarction Insulin-like growth factor-1 (IGF-1), a small protein/polypeptide with a short c... BeFree 24604065 Detail
<0.001 myocarditis NA BeFree Detail
<0.001 myositis NA BeFree Detail
0.002 Myotonic dystrophy NA BeFree Detail
0.006 Neoplasm Metastasis Elevated insulin levels have been associated with an increased cancer risk as we... BeFree 25012984 Detail
0.006 Neoplasm Metastasis The importance of the insulin-like growth factor, IGF, as a signaling axis in ca... BeFree 25095896 Detail
0.002 nephroblastoma NA BeFree Detail
<0.001 nervous system disorder NA BeFree Detail
0.006 Nesidioblastosis NA BeFree Detail
0.120 Neural Tube Defects NA CTD_human Detail
<0.001 neurilemmoma NA BeFree Detail
0.005 neuroblastoma NA BeFree Detail
<0.001 Nightmares NA BeFree Detail
<0.001 Nodule The major autopsy findings revealed hypertrophic cardiomyopathy, congenital myop... BeFree 25668678 Detail
0.004 Obesity, Morbid NA BeFree,GAD Detail
0.002 Oligomenorrhea NA GAD Detail
<0.001 oppositional defiant disorder NA BeFree Detail
<0.001 optic atrophy NA BeFree Detail
0.002 Degenerative polyarthritis NA BeFree Detail
<0.001 Cartilaginous exostosis Maximal insulin response following arginine challenge was also significantly att... BeFree 25541963 Detail
<0.001 osteoporosis NA BeFree Detail
0.002 osteosarcoma NA BeFree Detail
0.003 ovarian carcinoma Pregnancy-associated plasma protein-A (PAPP-A) plays a key role in promoting ins... BeFree 25695953 Detail
<0.001 Ovarian Cysts NA BeFree Detail
0.020 Ovarian Diseases NA BeFree Detail
<0.001 Pain Three specific genes in the pain group overlap with sleep quality, including ins... BeFree 25358868 Detail
<0.001 Pancreatic Diseases NA BeFree Detail
<0.001 Pancreatic Insufficiency NA BeFree Detail
0.003 Pancreatic Neoplasm NA BeFree,GAD Detail
0.121 pancreatitis NA BeFree,CTD_human Detail
0.120 panic disorder NA CTD_human Detail
<0.001 Paresis NA BeFree Detail
0.120 Paresthesia NA CTD_human Detail
0.125 Parkinson disease Our studies establish important function of ida-1 as a modulator in Daf-2/Daf-16... BeFree,CTD_human,GAD,LHGDN 25469508 Detail
<0.001 pemphigus vulgaris NA BeFree Detail
<0.001 Peptic Ulcer NA BeFree Detail
<0.001 Periodontal Diseases Insulin Response Genes in Different Stages of Periodontal Disease. BeFree 25924856 Detail
<0.001 periodontitis We conducted this study to examine whether insulin response genes are differenti... BeFree 25924856 Detail
<0.001 pheochromocytoma NA BeFree Detail
0.001 pituitary adenoma NA BeFree Detail
0.006 Pituitary Diseases A prospective study in 118 patients (mean age 47·7 ± 13·6 years, n = 52 women) u... BeFree 25200793 Detail
<0.001 Pituitary Neoplasms NA BeFree Detail
<0.001 poliomyelitis NA BeFree Detail
0.162 polycystic ovary syndrome Insulin resistance is a prominent feature of PCOS. BeFree,CTD_human,GAD,LHGDN 24876175 Detail
0.162 polycystic ovary syndrome Promoter SNPs of the HSD11B1 gene might exert a potential genetic protective rol... BeFree,CTD_human,GAD,LHGDN 24969481 Detail
0.162 polycystic ovary syndrome All the PCOS had elevated body mass index, waist circumference, waist-to-hip rat... BeFree,CTD_human,GAD,LHGDN 25083576 Detail
0.162 polycystic ovary syndrome Insulin resistance associated with abdominal obesity plays a leading role in the... BeFree,CTD_human,GAD,LHGDN 25093427 Detail
0.162 polycystic ovary syndrome The results from these studies demonstrate that the well-established abnormaliti... BeFree,CTD_human,GAD,LHGDN 25123125 Detail
0.162 polycystic ovary syndrome Association of insulin gene variable number of tandem repeats regulatory polymor... BeFree,CTD_human,GAD,LHGDN 25220536 Detail
<0.001 polycythemia vera NA BeFree Detail
0.003 polyps NA LHGDN Detail
<0.001 Polyuria NA BeFree Detail
0.002 Prader-Willi syndrome Compared with OCs, the PWS group had a decreased percentage of trunk FM and a be... BeFree 25478934 Detail
0.002 pre-eclampsia NA GAD Detail
0.002 Pregnancy in Diabetics NA BeFree Detail
<0.001 Preleukemia NA BeFree Detail
<0.001 Premenstrual syndrome Examples of the latter include mGluR5 antagonists in FXS, mTOR inhibitors in TSC... BeFree 25695134 Detail
<0.001 Prostatic Diseases NA BeFree Detail
0.124 Prostatic Neoplasms NA BeFree,CTD_human,LHGDN Detail
<0.001 Pseudorabies NA BeFree Detail
<0.001 psoriasis NA BeFree Detail
<0.001 Psychotic Disorders NA BeFree Detail
<0.001 pterygium NA BeFree Detail
<0.001 Precocious Puberty NA BeFree Detail
<0.001 pulmonary edema In the current study, in a lipopolysaccharide-based mouse model of ALI, we found... BeFree 25265063 Detail
<0.001 pulmonary emphysema NA BeFree Detail
<0.001 pulmonary fibrosis NA BeFree Detail
0.002 kidney failure NA BeFree Detail
<0.001 retinal degeneration NA BeFree Detail
0.005 Retinal Diseases NA BeFree Detail
<0.001 retinitis pigmentosa NA BeFree Detail
<0.001 retinoblastoma A multitude of molecular pathways well-described in carcinogenesis are regulated... BeFree 25048860 Detail
<0.001 Rett syndrome NA BeFree Detail
0.120 Rhabdomyolysis NA CTD_human Detail
0.002 rhabdomyosarcoma Interestingly, members of the miR-378 family presented as a possible target the ... BeFree 25427715 Detail
<0.001 rickets NA BeFree Detail
<0.001 rubella NA BeFree Detail
<0.001 Sarcoidosis, Pulmonary NA BeFree Detail
<0.001 Kaposi sarcoma NA BeFree Detail
<0.001 scabies NA BeFree Detail
<0.001 Schistosomiasis japonica These data re-emphasize the potential of the SjIRs as veterinary transmission bl... BeFree 25961574 Detail
0.374 Diabetes Mellitus, Non-Insulin-Dependent The aim of our study was to investigate whether common polymorphisms in the gene... BeFree 15127203 Detail
0.002 schizophrenia Evidence for disturbed insulin and growth hormone signaling as potential risk fa... BeFree 25158005 Detail
<0.001 systemic scleroderma NA BeFree Detail
0.121 Seizures NA BeFree,CTD_human Detail
<0.001 Septicemia NA BeFree Detail
0.003 siderosis NA BeFree,LHGDN Detail
<0.001 Dermatologic disorders NA BeFree Detail
<0.001 Skin Manifestations NA BeFree Detail
0.002 Stomach Neoplasms NA GAD Detail
<0.001 gastric ulcer NA BeFree Detail
<0.001 Stress, Psychological NA BeFree Detail
0.005 Cerebrovascular accident NA BeFree,LHGDN Detail
0.120 Tachycardia NA CTD_human Detail
<0.001 teratoma NA BeFree Detail
<0.001 Androgen-Insensitivity Syndrome NA BeFree Detail
<0.001 Testicular Neoplasms NA BeFree Detail
<0.001 tetanus NA BeFree Detail
<0.001 thalassemia NA BeFree Detail
0.002 Thinness NA GAD Detail
<0.001 Thyroid Diseases All patients presented with neonatal diabetes with a range of insulin sensitivit... BeFree 26259131 Detail
<0.001 Thyroid Neoplasm NA BeFree Detail
<0.001 Thyroid Nodule NA BeFree Detail
<0.001 tic disorder NA BeFree Detail
<0.001 Trisomy NA BeFree Detail
<0.001 Tuberculosis, Meningeal NA BeFree Detail
<0.001 tuberous sclerosis Examples of the latter include mGluR5 antagonists in FXS, mTOR inhibitors in TSC... BeFree 25695134 Detail
0.001 Turner syndrome NA BeFree Detail
<0.001 Unipolar Depression NA BeFree Detail
<0.001 uremia NA BeFree Detail
0.002 Uterine Fibroids NA BeFree Detail
0.003 Vascular Diseases NA BeFree Detail
0.120 Ventricular fibrillation NA CTD_human Detail
0.120 Ventricular Outflow Obstruction NA CTD_human Detail
0.002 Virus Diseases NA BeFree Detail
<0.001 Vitamin D Deficiency NA BeFree Detail
<0.001 Vitamin E Deficiency NA BeFree Detail
0.005 Weight Gain NA GAD Detail
0.002 Wolfram syndrome NA BeFree Detail
<0.001 Lymphoma, Large-Cell, Follicular NA BeFree Detail
<0.001 T-Cell Lymphoma The type I insulin-like growth factor receptor (IGF-IR) tyrosine kinase promotes... BeFree 25884514 Detail
0.003 motor neuron disease Recent evidence of IGF-1 axis alteration in spinal muscular atrophy (SMA), a ver... BeFree,LHGDN 26311784 Detail
<0.001 severe combined immunodeficiency NA BeFree Detail
0.024 gestational diabetes The elevated GLP-1 levels in gestational diabetes women suggested some abnormali... BeFree,GAD,LHGDN 24639413 Detail
0.024 gestational diabetes The GDM pregnant women were treated by diet control or diet control and insulin ... BeFree,GAD,LHGDN 24664457 Detail
0.024 gestational diabetes Increased hepatic lipid storage is an early abnormality in insulin resistant wom... BeFree,GAD,LHGDN 25083080 Detail
0.024 gestational diabetes Insulin requires normal expression and signaling of insulin receptor A to revers... BeFree,GAD,LHGDN 25351985 Detail
<0.001 Ovarian Failure, Premature NA BeFree Detail
<0.001 Neurofibrillary degeneration (morphologic abnormality) NA BeFree Detail
0.007 Polyendocrinopathies, Autoimmune NA GAD Detail
<0.001 Polycystic Kidney, Autosomal Dominant NA BeFree Detail
0.008 essential hypertension As 50% of patients with essential hypertension are insulin resistant and hyperin... BeFree 25133511 Detail
<0.001 Polydipsia NA BeFree Detail
<0.001 acute leukemia NA BeFree Detail
<0.001 Autoimmune Syndrome Type II, Polyglandular NA BeFree Detail
<0.001 cataract NA BeFree Detail
<0.001 benign neoplasm NA BeFree Detail
<0.001 Rous Sarcoma NA BeFree Detail
<0.001 Ataxia, Spinocerebellar NA BeFree Detail
0.001 Pancreatitis, Chronic NA BeFree Detail
<0.001 Epstein-Barr Virus Infections NA BeFree Detail
<0.001 Left Ventricular Hypertrophy NA BeFree Detail
0.001 Small cell carcinoma of lung NA BeFree Detail
<0.001 obstructive nephropathy NA BeFree Detail
<0.001 Atrophic condition of skin NA BeFree Detail
<0.001 renal fibrosis NA BeFree Detail
0.002 Myocardial Ischemia The mechanistic effects of intravenous glucose, insulin and potassium (GIK) in c... BeFree 25135348 Detail
<0.001 Muscle Weakness NA BeFree Detail
<0.001 Adenocarcinoma of lung (disorder) NA BeFree Detail
<0.001 esophageal carcinoma NA BeFree Detail
<0.001 hypertensive heart disease NA BeFree Detail
<0.001 Idiopathic pulmonary hypertension NA BeFree Detail
<0.001 Non-arthropod borne lymphocytic choriomeningitis NA BeFree Detail
<0.001 Malignant neoplasm of mouth NA BeFree Detail
<0.001 Secondary malignant neoplasm of lung NA BeFree Detail
<0.001 Secondary malignant neoplasm of bone NA BeFree Detail
<0.001 proliferative diabetic retinopathy NA BeFree Detail
<0.001 Hearing Loss, Mixed Conductive-Sensorineural NA BeFree Detail
<0.001 acute myocardial infarction NA BeFree Detail
<0.001 Atherosclerosis of aorta NA BeFree Detail
0.002 Disease of capillaries NA BeFree Detail
<0.001 allergic asthma NA BeFree Detail
<0.001 Acute gingivitis This study suggests that acute gingival inflammation may induce localized change... BeFree 25924856 Detail
0.020 Neonatal diabetes mellitus Neonatal diabetes in an infant of diabetic mother: same novel INS missense mutat... BeFree 24566359 Detail
0.020 Neonatal diabetes mellitus In permanent neonatal diabetes (PNDM) patients, homozygous GCK (n=6), EIF2AK3 (n... BeFree 25755231 Detail
0.020 Neonatal diabetes mellitus A family with permanent neonatal diabetes due to a novel mutation in INS gene. BeFree 25765664 Detail
0.020 Neonatal diabetes mellitus We have previously shown that amino acid changes in the human Kruppel-Like Facto... BeFree 26248217 Detail
0.020 Neonatal diabetes mellitus All patients presented with neonatal diabetes with a range of insulin sensitivit... BeFree 26259131 Detail
0.001 Ketonuria NA BeFree Detail
<0.001 adrenoleukodystrophy NA BeFree Detail
<0.001 Androgenetic Alopecia NA BeFree Detail
0.002 Malnutrition Different nutritional deficiencies such as a low availability of proteins in the... BeFree 25660337 Detail
0.002 Malnutrition Malnutrition in the elderly is accompanied by several metabolic dysfunctions, es... BeFree 25994005 Detail
0.120 Liver Failure, Acute NA CTD_human Detail
<0.001 acute intermittent porphyria NA BeFree Detail
<0.001 Mitochondrial Myopathies NA BeFree Detail
<0.001 MELAS syndrome NA BeFree Detail
<0.001 Cicatrix, Hypertrophic NA BeFree Detail
<0.001 Russell-Silver syndrome NA BeFree Detail
0.002 Autoimmune thyroid disease NA BeFree Detail
<0.001 Glomerulosclerosis (disorder) NA BeFree Detail
0.005 Tumor Progression Altogether, our data indicate that GPER1 may be included among the complex netwo... BeFree 25012984 Detail
0.009 Diabetes, Autoimmune We report a peculiar case of a GCK/MODY2 family in whom monogenic and autoimmune... BeFree 25467089 Detail
0.009 Diabetes, Autoimmune Currently, there is no treatment to restore endogenous insulin secretion in pati... BeFree 25604067 Detail
0.009 Diabetes, Autoimmune Materno-Fetal Transfer of Preproinsulin Through the Neonatal Fc Receptor Prevent... BeFree 25918233 Detail
0.001 Microvascular Angina NA BeFree Detail
0.004 hyperandrogenism Insulin resistance associated with abdominal obesity plays a leading role in the... BeFree 25093427 Detail
0.002 hepatoblastoma NA BeFree Detail
<0.001 Sarcoma, Clear Cell NA BeFree Detail
<0.001 smooth muscle tumor NA BeFree Detail
<0.001 embryonal carcinoma NA BeFree Detail
<0.001 Adenomatous Polyps NA BeFree Detail
0.001 adrenocortical carcinoma NA BeFree Detail
<0.001 Carcinoma, Endometrioid NA BeFree Detail
<0.001 cholangiocarcinoma NA BeFree Detail
<0.001 ganglioglioma NA BeFree Detail
<0.001 Neuroendocrine Tumors NA BeFree Detail
<0.001 uveal melanoma NA BeFree Detail
<0.001 Lip and oral cavity carcinoma NA BeFree Detail
<0.001 Metastatic malignant neoplasm to brain NA BeFree Detail
<0.001 Acquired partial lipodystrophy NA BeFree Detail
<0.001 Familial generalized lipodystrophy NA BeFree Detail
<0.001 Eruptive xanthoma NA BeFree Detail
<0.001 Premature aging syndrome Finally, the accelerated cellular senescence was also observed at the organismal... BeFree 25274775 Detail
<0.001 Premature aging syndrome Different nutritional deficiencies such as a low availability of proteins in the... BeFree 25660337 Detail
<0.001 Fibrillation NA BeFree Detail
<0.001 Memory impairment NA BeFree Detail
0.005 pancreatic carcinoma Liposomal insulin promoter-thymidine kinase gene therapy followed by ganciclovir... BeFree 25596375 Detail
<0.001 Inclusion Body Myositis (disorder) NA BeFree Detail
0.001 Gastrointestinal Stromal Tumors NA BeFree Detail
<0.001 pycnodysostosis NA BeFree Detail
<0.001 Papillary thyroid carcinoma NA BeFree Detail
0.002 Fibrosis, Liver NA BeFree Detail
<0.001 Prodrome NA BeFree Detail
<0.001 myotonic muscular dystrophy NA BeFree Detail
<0.001 color blindness NA BeFree Detail
0.008 Dyslipidemias NA BeFree Detail
<0.001 panhypopituitarism NA BeFree Detail
<0.001 islet cell tumor NA BeFree Detail
0.006 Malignant neoplasm of lung NA BeFree Detail
<0.001 age related macular degeneration NA BeFree Detail
<0.001 protein S deficiency NA BeFree Detail
0.120 Ventricular Dysfunction, Left NA CTD_human Detail
<0.001 Sepsis NA BeFree Detail
<0.001 autonomic neuropathy NA BeFree Detail
<0.001 Hearing problem NA BeFree Detail
<0.001 Chronic heart failure NA BeFree Detail
0.005 Donohue syndrome NA BeFree Detail
<0.001 Congenital hypoplasia of penis NA BeFree Detail
<0.001 cerebellar hypoplasia NA BeFree Detail
<0.001 Fibrosis of pancreas NA BeFree Detail
0.001 exocrine pancreatic insufficiency NA BeFree Detail
<0.001 Pancreatic acinar atrophy NA BeFree Detail
<0.001 Congenital glucose-galactose malabsorption NA BeFree Detail
<0.001 Niemann-Pick disease, type B NA BeFree Detail
0.001 Alstrom syndrome Here we investigated the role of Alms1 disruption in AT expansion and insulin re... BeFree 25299671 Detail
<0.001 methylmalonic acidemia NA BeFree Detail
<0.001 Renal glomerular disease NA BeFree Detail
<0.001 Endometrioma NA BeFree Detail
<0.001 Syndrome of infant of diabetic mother Neonatal diabetes in an infant of diabetic mother: same novel INS missense mutat... BeFree 24566359 Detail
<0.001 generalized anxiety disorder NA BeFree Detail
<0.001 Spastic syndrome NA BeFree Detail
<0.001 Severe myopia NA BeFree Detail
0.001 Somatotropin deficiency Complete and partial GHD were defined as peak GH responses of 5 and 7 μg/l (15 a... BeFree 25041402 Detail
0.001 Laron syndrome NA BeFree Detail
<0.001 Malnutrition related diabetes mellitus NA BeFree Detail
<0.001 Fibrocalculous pancreatic diabetes NA BeFree Detail
0.168 Impaired glucose tolerance NUCKS knockout mice exhibit decreased insulin signaling and increased body weigh... BeFree,CTD_human,LHGDN 24931609 Detail
0.168 Impaired glucose tolerance Furthermore, other than its established role in regulating insulin secretion by ... BeFree,CTD_human,LHGDN 24992457 Detail
0.168 Impaired glucose tolerance Insulin resistance, a hallmark of impaired glucose tolerance and type 2 diabetes... BeFree,CTD_human,LHGDN 25028245 Detail
0.168 Impaired glucose tolerance Here, we demonstrate that with progressive age, skeletal muscle-specific TWEAK-t... BeFree,CTD_human,LHGDN 25466899 Detail
0.168 Impaired glucose tolerance Thus, overexpression of human IGFBP-3 or its mutant devoid of IGF binding abilit... BeFree,CTD_human,LHGDN 25490144 Detail
0.168 Impaired glucose tolerance We have identified significant behavioural deficits, together with a degree of g... BeFree,CTD_human,LHGDN 25681319 Detail
0.168 Impaired glucose tolerance Maternal alcohol intake around the time of conception causes glucose intolerance... BeFree,CTD_human,LHGDN 25733565 Detail
0.168 Impaired glucose tolerance Adult Tshz1(+/-) mice display glucose intolerance due to defects in glucose-stim... BeFree,CTD_human,LHGDN 25918232 Detail
0.168 Impaired glucose tolerance HFD-fed GPR43 knockout (KO) mice develop glucose intolerance due to a defect in ... BeFree,CTD_human,LHGDN 26023106 Detail
0.168 Impaired glucose tolerance Moreover, islet-specific Senp1 deletion in mice caused impaired glucose toleranc... BeFree,CTD_human,LHGDN 26389676 Detail
<0.001 Insulin Receptor, Defect in NA BeFree Detail
0.002 Rabson-Mendenhall syndrome NA BeFree Detail
0.002 Fasting Hypoglycemia NA BeFree Detail
<0.001 Reactive hypoglycemia NA BeFree Detail
<0.001 Spontaneous hypoglycemia NA BeFree Detail
<0.001 Hereditary persistence of fetal hemoglobin thalassemia NA BeFree Detail
<0.001 inflammatory breast carcinoma NA BeFree Detail
<0.001 gastric adenocarcinoma NA BeFree Detail
<0.001 Malignant Childhood Neoplasm NA BeFree Detail
<0.001 Cancer of Head and Neck NA BeFree Detail
<0.001 Liver and Intrahepatic Biliary Tract Carcinoma NA BeFree Detail
<0.001 Squamous cell carcinoma of esophagus NA BeFree Detail
<0.001 Adenocarcinoma Of Esophagus NA BeFree Detail
<0.001 pancreatic beta islet cell adenoma NA BeFree Detail
0.002 Iron Overload NA BeFree Detail
<0.001 Vascular Neoplasms NA BeFree Detail
<0.001 Very Low Birth Weight NA BeFree Detail
0.001 cervix carcinoma NA BeFree Detail
0.006 Obesity, Abdominal Insulin resistance associated with abdominal obesity plays a leading role in the... BeFree 25093427 Detail
<0.001 Restenosis NA BeFree Detail
<0.001 cystic disease NA BeFree Detail
<0.001 Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse NA BeFree Detail
<0.001 Adenocarcinoma of colon NA BeFree Detail
0.003 Impaired cognition NA BeFree Detail
0.001 Proliferative retinopathy NA BeFree Detail
<0.001 Autosomal dominant retinitis pigmentosa NA BeFree Detail
<0.001 Familial primary pulmonary hypertension NA BeFree Detail
<0.001 Chronic liver disease NA BeFree Detail
0.002 transient neonatal diabetes mellitus NA BeFree Detail
0.104 Maturity onset diabetes mellitus in young Genetic testing for maturity-onset diabetes of the young (MODY) may be relevant ... BeFree,MGD 24736738 Detail
0.104 Maturity onset diabetes mellitus in young The mean centroid of gene expression of T2DM and MODY pathways was shown to be a... BeFree,MGD 25379510 Detail
0.104 Maturity onset diabetes mellitus in young Structural and functional study of the GlnB22-insulin mutant responsible for mat... BeFree,MGD 25423173 Detail
0.104 Maturity onset diabetes mellitus in young Frameshift mutations in the insulin gene leading to prolonged molecule of insuli... BeFree,MGD 25721872 Detail
0.104 Maturity onset diabetes mellitus in young We have previously shown that amino acid changes in the human Kruppel-Like Facto... BeFree,MGD 26248217 Detail
<0.001 Diabetes mellitus autosomal dominant type II (disorder) NA BeFree Detail
0.123 Hyperproinsulinemia NA BeFree,UNIPROT Detail
0.002 Diabetes-deafness syndrome maternally transmitted (disorder) NA BeFree Detail
0.001 Insulin resistance in diabetes NA BeFree Detail
0.002 Insulin resistance - type A NA BeFree Detail
<0.001 Precocious pubarche NA BeFree Detail
<0.001 Premature adrenarche NA BeFree Detail
<0.001 Generalized glycogen storage disease of infants NA BeFree Detail
<0.001 Android obesity NA BeFree Detail
<0.001 Malignant neoplasm of liver NA BeFree Detail
0.001 Breast Cancer, Familial NA BeFree Detail
0.004 Malignant neoplasm of pancreas Liposomal insulin promoter-thymidine kinase gene therapy followed by ganciclovir... BeFree 25596375 Detail
<0.001 Disseminated Malignant Neoplasm Elevated insulin levels have been associated with an increased cancer risk as we... BeFree 25012984 Detail
<0.001 Nonorganic psychosis NA BeFree Detail
0.008 prediabetes syndrome There is a growing interest in food constituents that could reduce intestinal gl... BeFree 25074384 Detail
0.008 prediabetes syndrome In contrast, in pre-diabetic conditions, reduced oxidative capacity, high levels... BeFree 25226800 Detail
0.008 prediabetes syndrome Insulin levels (mRNA/protein) were higher in AT derived from prediabetes BB rats... BeFree 25743104 Detail
0.008 prediabetes syndrome The aim of our study was to investigate associations between these novel risk va... BeFree 25799151 Detail
0.029 Malignant neoplasm of prostate Genetic variation at insulin-like growth factor 1 (IGF1) has been linked to pros... BeFree,GAD 24904019 Detail
0.029 Malignant neoplasm of prostate Inhibition of the mitogenic insulin-like growth factor receptor 1 (IGF-1R) signa... BeFree,GAD 25344862 Detail
0.029 Malignant neoplasm of prostate The insulin-like growth factor (IGF)/Akt signaling pathway appears to be the key... BeFree,GAD 25533015 Detail
0.029 Malignant neoplasm of prostate The insulin-like growth factor (IGF) axis as an anticancer target in prostate ca... BeFree,GAD 26231734 Detail
0.001 Hereditary hemochromatosis NA BeFree Detail
<0.001 thrombophilia NA BeFree Detail
<0.001 Low renal threshold for glucose NA BeFree Detail
<0.001 Muscle damage NA BeFree Detail
<0.001 Eichsfeld type congenital muscular dystrophy NA BeFree Detail
0.002 Congenital Myotonic Dystrophy NA BeFree Detail
<0.001 Skeletal dysplasia NA BeFree Detail
<0.001 Hypochondroplasia (disorder) NA BeFree Detail
<0.001 Adolescent idiopathic scoliosis NA BeFree Detail
<0.001 Developmental delay (disorder) NA BeFree Detail
<0.001 Anovulatory NA BeFree Detail
<0.001 Dysmorphic features NA BeFree Detail
<0.001 Wolcott-Rallison syndrome A 3 year old patient with NDM diagnosed at 3 months of age, who previously teste... BeFree 25306193 Detail
<0.001 Klinefelter's syndrome - male with more than two X chromosomes NA BeFree Detail
0.001 neuropathy NA BeFree Detail
<0.001 Simple obesity NA BeFree Detail
<0.001 Soft tissue mass NA BeFree Detail
0.004 endometrial carcinoma As metformin can inhibit endometrial carcinoma (EC) cell growth and the insulin ... BeFree 25640355 Detail
0.004 endometrial carcinoma This study provides evidence to support a causal association of higher insulin l... BeFree 26134033 Detail
<0.001 Secondary malignant neoplasm of liver NA BeFree Detail
0.004 dementia Long-acting intranasal insulin detemir improves cognition for adults with mild c... BeFree 25374101 Detail
<0.001 Benign neurologic neoplasms NA BeFree Detail
0.005 body mass NA GAD Detail
<0.001 Chronic active hepatitis NA BeFree Detail
<0.001 Sleep Apnea, Obstructive NA BeFree Detail
<0.001 Recurrent tumor NA BeFree Detail
<0.001 Bilateral cataracts (disorder) NA BeFree Detail
0.120 Paralysed NA CTD_human Detail
0.167 Metabolic syndrome X Insulin-sensitizing thiazolidinediones exert a pleiotropic pharmacology with the... BeFree,CTD_human 24774061 Detail
0.167 Metabolic syndrome X Effect of dietary fat modification on subcutaneous white adipose tissue insulin ... BeFree,CTD_human 25044988 Detail
0.167 Metabolic syndrome X Association of common genetic variants with diabetes and metabolic syndrome rela... BeFree,CTD_human 25060389 Detail
0.167 Metabolic syndrome X Insulin resistance (IR) is a distinct and early feature of type 2 diabetes melli... BeFree,CTD_human 25060738 Detail
0.167 Metabolic syndrome X We also discuss relevant issues such as the role of leptin, insulin and renin-an... BeFree,CTD_human 25084549 Detail
0.167 Metabolic syndrome X Plasma EETs correlated with insulin sensitivity index (r=0.64, p=0.015 for total... BeFree,CTD_human 25173047 Detail
0.167 Metabolic syndrome X Insulin resistance is a major hallmark of metabolic syndromes, including Type 2 ... BeFree,CTD_human 25222560 Detail
0.167 Metabolic syndrome X Preserved Na/HCO3 cotransporter sensitivity to insulin may promote hypertension ... BeFree,CTD_human 25354240 Detail
0.167 Metabolic syndrome X Regression analysis showed significant correlation of body mass index, waist and... BeFree,CTD_human 25639755 Detail
0.167 Metabolic syndrome X A LGI diet, particularly associated with the use of Policaptil Gel Retard, may r... BeFree,CTD_human 25774705 Detail
0.167 Metabolic syndrome X We investigated the association of various lipoprotein traits, apolipoproteins a... BeFree,CTD_human 25818853 Detail
0.167 Metabolic syndrome X After further adjustment for the adiponectin levels, participants with a minor a... BeFree,CTD_human 25875811 Detail
0.167 Metabolic syndrome X In addition this SNP may play a role in the development of cardiovascular diseas... BeFree,CTD_human 26051417 Detail
0.002 Neurodegenerative Disorders Important inconsistencies have emerged recently regarding the role of insulin-li... BeFree 25200290 Detail
<0.001 Hepatitis B, Chronic NA BeFree Detail
0.007 Hepatitis C, Chronic Insulin resistance (IR) affects sustained virological response (SVR) to peginter... BeFree 24974131 Detail
0.007 Hepatitis C, Chronic Insulin resistance, adipokine profile and hepatic expression of SOCS-3 gene in c... BeFree 25132761 Detail
0.007 Hepatitis C, Chronic Insulin resistance and liver steatosis in chronic hepatitis C infection genotype... BeFree 25386071 Detail
0.007 Hepatitis C, Chronic Insulin-like growth factor-1 mRNA isoforms and insulin-like growth factor-1 rece... BeFree 25852271 Detail
<0.001 Malignant neoplasm of esophagus NA BeFree Detail
<0.001 X-Linked Lymphoproliferative Disorder NA BeFree Detail
0.012 Overweight MC4R variants were detected in three patients: the known I169S variant was found... BeFree 19214805 Detail
0.193 hyperinsulinism MC4R variants were detected in three patients: the known I169S variant was found... BeFree 19214805 Detail
0.002 Thyroid carcinoma NA BeFree Detail
<0.001 Ewings sarcoma NA BeFree Detail
<0.001 Malignant glioma NA BeFree Detail
<0.001 Insulin allergy NA BeFree Detail
<0.001 Loss of scalp hair NA BeFree Detail
<0.001 Equilibration disorder NA BeFree Detail
<0.001 Carotid Atherosclerosis Significant improvements in classical and emerging CVD risk factors also support... BeFree 25940230 Detail
0.002 Osteosarcoma of bone NA BeFree Detail
0.295 diabetes mellitus The E23K polymorphism of the pancreatic beta-cell ATP-sensitive K(+) (K(ATP)) ch... BeFree 12540638 Detail
0.374 Diabetes Mellitus, Non-Insulin-Dependent The E23K variant of Kir6.2 associates with impaired post-OGTT serum insulin resp... BeFree 12540638 Detail
0.080 Diabetes The E23K polymorphism of the pancreatic beta-cell ATP-sensitive K(+) (K(ATP)) ch... BeFree 12540638 Detail
0.168 Impaired glucose tolerance We conclude that the lysine variant in KCNJ11 E23K leads to diminished insulin s... BeFree 17259403 Detail
<0.001 Carcinoma of larynx NA BeFree Detail
0.015 Carcinogenesis Insulin-like growth factors (IGFs) can promote tumorigenesis via inhibiting the ... BeFree 25592043 Detail
<0.001 Islets of Langerhans hyperplasia NA BeFree Detail
0.002 genetic hypertension NA BeFree Detail
<0.001 hyperhomocysteinemia NA BeFree Detail
0.002 schizophrenia Forty-nine patients, with schizophrenia or schizoaffective disorder and treated ... BeFree 20521326 Detail
0.018 prostate carcinoma Genetic variation at insulin-like growth factor 1 (IGF1) has been linked to pros... BeFree 24904019 Detail
0.018 prostate carcinoma Inhibition of the mitogenic insulin-like growth factor receptor 1 (IGF-1R) signa... BeFree 25344862 Detail
0.018 prostate carcinoma The insulin-like growth factor (IGF)/Akt signaling pathway appears to be the key... BeFree 25533015 Detail
0.018 prostate carcinoma The insulin-like growth factor (IGF) axis as an anticancer target in prostate ca... BeFree 26231734 Detail
<0.001 toxic shock syndrome NA BeFree Detail
0.003 Hashimoto Disease NA BeFree,GAD Detail
0.004 Epithelial ovarian cancer NA BeFree,GAD Detail
<0.001 Progressive Neoplastic Disease Type 2 diabetes mellitus (T2DM) is a progressive disease resulting from increasi... BeFree 25539584 Detail
0.045 breast carcinoma Insulin resistance and inflammation may mediate the effects of central adiposity... BeFree 25056184 Detail
0.045 breast carcinoma Insulin growth factor binding protein-5 (IGFBP-5) can show different effects on ... BeFree 25422220 Detail
0.045 breast carcinoma The insulin-like growth factor type I receptor (IGF1R) is frequently dysregulate... BeFree 25465188 Detail
0.045 breast carcinoma Epidemiologic studies have shown that diabetics receiving the biguanide metformi... BeFree 25681088 Detail
0.045 breast carcinoma The role of the insulin-like growth factor-1 system in breast cancer. BeFree 25743390 Detail
0.045 breast carcinoma Induction of anterior gradient 2 (AGR2) plays a key role in insulin-like growth ... BeFree 25956506 Detail
<0.001 polycythemia vera Expression of the JAK2 V617F mutant renders Ba/F3 cells hypersensitive to insuli... BeFree 16239216 Detail
0.006 Carcinoma of lung NA BeFree Detail
<0.001 Malignant neoplasm of gastrointestinal tract NA BeFree Detail
<0.001 Secondary malignant neoplasm of lymph node NA BeFree Detail
<0.001 heavy drinking NA BeFree Detail
<0.001 Moderate obesity NA BeFree Detail
0.005 colon carcinoma NA BeFree Detail
0.004 stomach carcinoma To study the expression of insulin-like growth factor binding proteins (IGFBPs) ... BeFree 25081695 Detail
0.004 stomach carcinoma Here, we reported significantly higher levels of serum insulin-like growth facto... BeFree 25596089 Detail
0.001 Carcinoma of bladder NA BeFree Detail
0.005 Central neuroblastoma NA BeFree Detail
<0.001 Observation of Neuromuscular Block NA BeFree Detail
<0.001 acne To evaluate the possible role of insulin-like growth factor (IGF)-1 in acne vulg... BeFree 25803999 Detail
<0.001 diabetic macular edema NA BeFree Detail
0.003 Microalbuminuria NA BeFree Detail
<0.001 Disorder of macula of retina NA BeFree Detail
<0.001 bile duct carcinoma NA BeFree Detail
<0.001 Middle Cerebral Artery Occlusion NA BeFree Detail
<0.001 hyperuricemia NA BeFree Detail
<0.001 Malignant neoplasm of kidney NA BeFree Detail
0.001 Premenopausal breast cancer NA BeFree Detail
<0.001 Cardiac defects NA BeFree Detail
0.001 growth hormone treatment Genetic markers of insulin sensitivity and insulin secretion are associated with... BeFree 25494864 Detail
0.001 growth hormone treatment SHOX gene variants: growth hormone/insulin-like growth factor-1 status and respo... BeFree 25659810 Detail
<0.001 Hyperlipoproteinemia Type IIa NA BeFree Detail
<0.001 Hypoglycaemic episode Group C (three patients with fasting hypoglycemic episodes) displayed very low r... BeFree 26116696 Detail
<0.001 Chronic lung disease NA BeFree Detail
<0.001 metabolic disturbance NA BeFree Detail
<0.001 Ovarian failure NA BeFree Detail
<0.001 early pregnancy NA BeFree Detail
<0.001 biliary tract cancer NA BeFree Detail
<0.001 adult acute lymphocytic leukemia NA BeFree Detail
<0.001 Mitochondrial Diseases Therefore, multiple defects in insulin and glucose metabolism are required for D... BeFree 25086207 Detail
<0.001 Parkinsonism, Juvenile NA BeFree Detail
<0.001 Ballismus NA BeFree Detail
0.120 Lewy Body Disease NA BeFree,CTD_human Detail
<0.001 Smith-Magenis syndrome NA BeFree Detail
<0.001 SIMPSON-GOLABI-BEHMEL SYNDROME, TYPE 1 NA BeFree Detail
<0.001 alcohol-related liver disease NA BeFree Detail
<0.001 malignant pleural mesothelioma NA BeFree Detail
<0.001 21-hydroxylase deficiency NA BeFree Detail
0.120 Diabetic Cardiomyopathies NA CTD_human Detail
0.001 Insulin resistant diabetes NA BeFree Detail
<0.001 Cells in urine NA BeFree Detail
0.003 Insulin autoimmune syndrome Insulin autoimmune syndrome (IAS, Hirata disease) is a rare cause of spontaneous... BeFree 24111525 Detail
<0.001 Fat redistribution NA BeFree Detail
0.003 Endothelial dysfunction NA BeFree Detail
<0.001 Cholesterol gallstones NA BeFree Detail
<0.001 Carcinogenicity NA BeFree Detail
<0.001 Diabetic gastropathy NA BeFree Detail
<0.001 Cardiomyopathies NA BeFree Detail
<0.001 Growth failure NA BeFree Detail
<0.001 Sleeplessness NA BeFree Detail
0.005 autoimmune thyroiditis NA BeFree,GAD,LHGDN Detail
0.002 Insulin Sensitivity NA GAD Detail
<0.001 Metastatic Prostate Carcinoma NA BeFree Detail
0.003 cholecystolithiasis NA BeFree,GAD Detail
<0.001 Vascular inflammations NA BeFree Detail
<0.001 Ischemic stroke NA BeFree Detail
<0.001 Acute coronary syndrome NA BeFree Detail
<0.001 Colorectal cancer metastatic NA BeFree Detail
<0.001 Arthritis, Collagen-Induced NA BeFree Detail
<0.001 Cholestasis in newborn NA BeFree Detail
<0.001 Critical illness myopathy NA BeFree Detail
0.005 Malignant neoplasm of ovary Pregnancy-associated plasma protein-A (PAPP-A) plays a key role in promoting ins... BeFree,GAD 25695953 Detail
<0.001 endometrial adenocarcinoma NA BeFree Detail
<0.001 Squamous cell carcinoma of the head and neck Expression levels of insulin-like growth factors 1 and 2 in head and neck squamo... BeFree 24802266 Detail
0.001 Glucose Metabolism Disorders NA BeFree Detail
0.001 Compensatory Hyperinsulinemia Alterations in insulin stimulated trafficking of glucose transporter 4 are an ea... BeFree 25299671 Detail
0.001 sarcoma NA BeFree Detail
<0.001 Lymphocytic infiltration NA BeFree Detail
0.120 Weight decreased NA CTD_human Detail
<0.001 Chronic metabolic disorder Type II diabetes mellitus (T2D) is a chronic metabolic disorder that results fro... BeFree 26770982 Detail
<0.001 attention deficit hyperactivity disorder NA BeFree Detail
<0.001 Atypical teratoid/rhabdoid tumor NA BeFree Detail
0.001 Mild cognitive disorder Intranasal (IN) insulin acutely improves verbal memory in mild cognitive impairm... BeFree 25373630 Detail
0.001 Mild cognitive disorder Long-acting intranasal insulin detemir improves cognition for adults with mild c... BeFree 25374101 Detail
0.001 Mild cognitive disorder Association of insulin-like growth factor-1 with mild cognitive impairment and s... BeFree 25467636 Detail
0.007 Systemic arterial pressure NA GAD Detail
<0.001 Xanthoma diabeticorum (disorder) NA BeFree Detail
0.002 Lipoatrophy NA BeFree Detail
<0.001 Familial obesity NA BeFree Detail
<0.001 Chronic inflammatory disorder Insulin resistance, selfish brain, and selfish immune system: an evolutionarily ... BeFree 25608958 Detail
<0.001 Precursor B-cell lymphoblastic leukemia NA BeFree Detail
<0.001 Precursor T cell lymphoblastic leukemia/lymphoblastic lymphoma Inhibition of type I insulin-like growth factor receptor tyrosine kinase by picr... BeFree 24206093 Detail
<0.001 Adenoma of large intestine NA BeFree Detail
<0.001 Adenocarcinoma of large intestine NA BeFree Detail
<0.001 childhood leukemia NA BeFree Detail
<0.001 Endocrine Syndrome NA BeFree Detail
0.001 pancreatic ductal adenocarcinoma Co-expression of both c-kit and KRAS, typical markers for CSC with overlapping w... BeFree 23978330 Detail
<0.001 differentiated thyroid gland carcinoma NA BeFree Detail
<0.001 renal carcinoma NA BeFree Detail
<0.001 Conn Syndrome NA BeFree Detail
<0.001 Penis agenesis NA BeFree Detail
<0.001 Carbohydrate intolerance NA BeFree Detail
0.006 Mammary Neoplasms NA BeFree,LHGDN Detail
<0.001 histiocytoma NA BeFree Detail
<0.001 Fetal malnutrition without mention of light-for-dates NA BeFree Detail
0.001 Hepatocarcinogenesis NA BeFree Detail
<0.001 Mammary Tumorigenesis NA BeFree Detail
<0.001 Primary Glioblastoma NA BeFree Detail
<0.001 Tumor Angiogenesis NA BeFree Detail
<0.001 Tumor Promotion NA BeFree Detail
0.016 colorectal cancer Body size, physical activity, early-life energy restriction, and associations wi... BeFree,GAD 24972776 Detail
0.016 colorectal cancer Body size, physical activity, genetic variants in the insulin-like growth factor... BeFree,GAD 26025909 Detail
<0.001 Ductal Breast Carcinoma NA BeFree Detail
<0.001 Hyperplastic obesity NA BeFree Detail
<0.001 Overweight and obesity NA BeFree Detail
0.121 Renal Insufficiency NA BeFree,CTD_human Detail
<0.001 Adenocarcinoma, Endometrioid NA BeFree Detail
<0.001 Glioblastoma multiforme NA BeFree Detail
0.002 Cirrhosis NA BeFree Detail
<0.001 tumor vasculature Important mechanisms we discuss include (1) improved DNA repair in normal, but n... BeFree 24436017 Detail
0.120 Cystic Kidney Diseases NA CTD_human Detail
0.001 Benign Prostatic Hyperplasia NA BeFree Detail
<0.001 Hyperlipoproteinemia Type IIb NA BeFree Detail
<0.001 Peripheral Arterial Diseases NA BeFree Detail
<0.001 HIV Lipodystrophy NA BeFree Detail
<0.001 Endometrial Diseases NA BeFree Detail
<0.001 Dysmorphism NA BeFree Detail
<0.001 Idiopathic Pulmonary Fibrosis NA BeFree Detail
0.002 Diabetes mellitus, transient neonatal, 1 A variable phenotype was associated with the homozygous c.-331C>A INS mutation, ... BeFree 25755231 Detail
0.568 DIABETES MELLITUS, PERMANENT NEONATAL We report four cases of PNDM.None of the infants or their parents had INS, KCNJ1... BeFree,CLINVAR,CTD_human,MGD,ORPHANET,UNIPROT 25052923 Detail
<0.001 Insulin-Like Growth Factor I Deficiency NA BeFree Detail
0.001 MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 3 (disorder) NA BeFree Detail
0.001 MAJOR AFFECTIVE DISORDER 2 NA BeFree Detail
<0.001 IMMUNE SUPPRESSION NA BeFree Detail
<0.001 Mammographic Density NA BeFree Detail
0.001 Hyperinsulinemic hypoglycemia, familial, 6 NA BeFree Detail
<0.001 Insulin-Like Growth Factor I, Resistance To NA BeFree Detail
<0.001 Pygmy (disorder) NA BeFree Detail
0.240 DIABETES MELLITUS, INSULIN-DEPENDENT, 2 NA CTD_human,UNIPROT Detail
0.120 Maturity-Onset Diabetes of the Young, Type 1 NA BeFree,CTD_human Detail
0.001 MAJOR AFFECTIVE DISORDER 1 NA BeFree Detail
<0.001 Neutral Lipid Storage Disease with Myopathy NA BeFree Detail
0.120 22q13.3 Deletion Syndrome NA BeFree,CTD_human Detail
<0.001 Syndactyly, Type IV NA BeFree Detail
0.003 uterine corpus cancer This study provides evidence to support a causal association of higher insulin l... BeFree 26134033 Detail
<0.001 Osteophyte NA BeFree Detail
0.008 coronary artery disease NA BeFree Detail
<0.001 Latent autoimmune diabetes mellitus in adult NA BeFree Detail
<0.001 Dysglycemia NA BeFree Detail
<0.001 Precursor Cell Lymphoblastic Leukemia Lymphoma NA BeFree Detail
0.001 MAJOR AFFECTIVE DISORDER 4 NA BeFree Detail
0.001 MAJOR AFFECTIVE DISORDER 5 NA BeFree Detail
0.001 MAJOR AFFECTIVE DISORDER 6 NA BeFree Detail
<0.001 Photoreceptor degeneration NA BeFree Detail
0.022 liver carcinoma Although the involvement of insulin-like signaling in cancer has been well docum... BeFree,GAD 24758241 Detail
0.022 liver carcinoma In the present study, we report a novel insulin-like growth factor 1 (IGF1) path... BeFree,GAD 25420499 Detail
0.022 liver carcinoma To unravel the role of interleukin (IL)-6 and insulin-like growth factor (IGF)-I... BeFree,GAD 25564572 Detail
0.022 liver carcinoma As the insulin-like growth factor (IGF) axis is a highly tumorigenic pathway in ... BeFree,GAD 25739014 Detail
0.022 liver carcinoma In addition, recent study demonstrates AFB1 positively regulates type I insulin-... BeFree,GAD 25820822 Detail
0.001 Chronic kidney disease stage 5 NA BeFree Detail
0.003 Pediatric Obesity Insulin resistance may develop in early stage of childhood obesity and in very y... BeFree 25868061 Detail
0.003 Pediatric Obesity Studies examining vitamin D levels in association with childhood obesity usually... BeFree 26317560 Detail
0.120 Acute kidney injury NA CTD_human Detail
<0.001 Hypoadiponectinemia NA BeFree Detail
0.001 Major affective disorder 7 NA BeFree Detail
0.001 MAJOR AFFECTIVE DISORDER 8 NA BeFree Detail
0.001 MAJOR AFFECTIVE DISORDER 9 NA BeFree Detail
0.004 Steatohepatitis DBC1 KO mice fed a high-fat diet, although obese, remained insulin sensitive, ha... BeFree 25053585 Detail
0.004 Steatohepatitis Insulin resistance and liver steatosis in chronic hepatitis C infection genotype... BeFree 25386071 Detail
0.004 Steatohepatitis Hepatocyte Nicotinamide Adenine Dinucleotide Phosphate Reduced Oxidase 4 Regulat... BeFree 25888330 Detail
<0.001 Short stature (child) NA BeFree Detail
0.005 Weight Gain Adverse Event NA GAD Detail
<0.001 Testicular dysgenesis syndrome NA BeFree Detail
<0.001 Polycystic kidney disease, type 1 NA BeFree Detail
<0.001 Nasopharyngeal carcinoma NA BeFree Detail
0.005 Hyperinsulinemic hypoglycemia, familial, 2 NA BeFree Detail
0.004 Obesity, Visceral NA BeFree Detail
0.001 Plaque, Amyloid NA BeFree Detail
<0.001 Congenital adrenal hyperplasia due to 21 hydroxylase deficiency NA BeFree Detail
<0.001 Pulmonary arterial hypertension NA BeFree Detail
<0.001 Fetal Alcohol Spectrum Disorders NA BeFree Detail
0.240 Maturity-onset diabetes of the young, type 10 NA CTD_human,UNIPROT Detail
0.001 Nonalcoholic Steatohepatitis Inhibitors of NOX4 reduce liver inflammation and fibrosis and increase insulin s... BeFree 25888330 Detail
<0.001 Ischemic Cerebrovascular Accident NA BeFree Detail
<0.001 Homocysteinemia NA BeFree Detail
<0.001 Fanconi-Bickel syndrome NA BeFree Detail
0.002 Juvenile arthritis NA GAD Detail
<0.001 Progressive cGVHD Type 2 diabetes mellitus (T2DM) is a progressive disease resulting from increasi... BeFree 25539584 Detail
<0.001 Triple Negative Breast Neoplasms NA BeFree Detail
<0.001 Hypertriglyceridemic Waist NA BeFree Detail
<0.001 Unspecified visual loss NA BeFree Detail
<0.001 Meckel syndrome type 1 NA BeFree Detail
<0.001 Multicystic Dysplastic Kidney NA BeFree Detail
0.008 Insulin resistance syndrome NA BeFree Detail
<0.001 juvenile rheumatoid arthritis NA BeFree Detail
<0.001 Isolated somatotropin deficiency NA BeFree Detail
<0.001 Pulmonary hypertension, primary, 1, with hereditary hemorrhagic telangiectasia NA BeFree Detail
<0.001 Experimental Organism Basal Cell Carcinoma NA BeFree Detail
<0.001 Obesity in animals NA BeFree Detail
<0.001 Diabetes in youth NA BeFree Detail
<0.001 Hypoglycemia in children NA BeFree Detail
0.002 Diabetes in children NA BeFree Detail
<0.001 Pre-Gestational Diabetes NA BeFree Detail
0.120 Neurocognitive Disorders NA CTD_human Detail
0.001 Congenital Abnormality NA BeFree Detail
0.003 acanthosis nigricans NA BeFree Detail
<0.001 achondroplasia NA BeFree Detail
<0.001 Acne Vulgaris To evaluate the possible role of insulin-like growth factor (IGF)-1 in acne vulg... BeFree 25803999 Detail
0.005 acromegaly NA BeFree,LHGDN Detail
<0.001 Acute Disease NA BeFree Detail
0.002 Addison Disease NA GAD Detail
0.002 adenocarcinoma NA BeFree Detail
0.007 adenoma NA BeFree,LHGDN Detail
<0.001 Adrenal Gland Neoplasms NA BeFree Detail
0.120 Albuminuria NA CTD_human Detail
<0.001 Alcoholic Intoxication, Chronic NA BeFree Detail
0.213 Alzheimer's disease We also discuss relevant issues such as the role of leptin, insulin and renin-an... BeFree,CTD_human,GAD,LHGDN,RGD 25084549 Detail
0.213 Alzheimer's disease Insulin resistance and type 2 diabetes are associated with clinical Alzheimer's ... BeFree,CTD_human,GAD,LHGDN,RGD 25200290 Detail
0.213 Alzheimer's disease D2M is linked with Alzheimer's disease through deregulation of calcium ions ther... BeFree,CTD_human,GAD,LHGDN,RGD 25230224 Detail
0.213 Alzheimer's disease A regulatory role for the insulin- and BDNF-linked RORA in the hippocampus: impl... BeFree,CTD_human,GAD,LHGDN,RGD 25362032 Detail
0.213 Alzheimer's disease A single-dose pilot trial of intranasal rapid-acting insulin in apolipoprotein E... BeFree,CTD_human,GAD,LHGDN,RGD 25373630 Detail
0.213 Alzheimer's disease Long-acting intranasal insulin detemir improves cognition for adults with mild c... BeFree,CTD_human,GAD,LHGDN,RGD 25374101 Detail
0.213 Alzheimer's disease The decrease in serum insulin-like growth factor-1 (IGF-I) with aging is related... BeFree,CTD_human,GAD,LHGDN,RGD 25467636 Detail
0.213 Alzheimer's disease Partial Loss of the Glutamate Transporter GLT-1 Alters Brain Akt and Insulin Sig... BeFree,CTD_human,GAD,LHGDN,RGD 25589729 Detail
0.002 amenorrhea NA GAD Detail
0.001 amyloidosis NA BeFree Detail
0.001 amyotrophic lateral sclerosis NA BeFree Detail
<0.001 Anaplasia NA BeFree Detail
<0.001 Cooley's anemia NA BeFree Detail
<0.001 Anemia, Pernicious NA BeFree Detail
<0.001 Angina, Unstable NA BeFree Detail
<0.001 cutaneous fibrous histiocytoma NA BeFree Detail
<0.001 aniridia NA BeFree Detail
<0.001 Anophthalmos NA BeFree Detail
<0.001 Anorexia NA BeFree Detail
<0.001 anorexia nervosa NA BeFree Detail
<0.001 anovulation NA BeFree Detail
<0.001 aortic valve insufficiency NA BeFree Detail
0.021 arteriosclerosis Insulin resistance aggravates atherosclerosis by reducing vascular smooth muscle... BeFree 24788416 Detail
0.002 rheumatoid arthritis Inhibition of the insulin-like growth factor system is a potential therapy for r... BeFree 25352179 Detail
0.002 rheumatoid arthritis These findings suggest that insulin/IRS-1 signaling is important in the pathogen... BeFree 25760103 Detail
0.001 Astrocytoma NA BeFree Detail
<0.001 Ataxia NA BeFree Detail
<0.001 ataxia telangiectasia NA BeFree Detail
0.034 atherosclerosis Insulin resistance aggravates atherosclerosis by reducing vascular smooth muscle... BeFree,GAD,LHGDN 24788416 Detail
<0.001 Tooth Attrition NA BeFree Detail
0.026 Autoimmune Diseases Diabetes mellitus type 1 (DM1) is an autoimmune disease that gradually destroys ... BeFree,GAD 25157497 Detail
0.026 Autoimmune Diseases Type 1 diabetes (T1D) is an autoimmune disease which is caused by destruction of... BeFree,GAD 25661663 Detail
0.002 Beckwith-Wiedemann syndrome NA BeFree Detail
0.002 Bile Duct Neoplasms NA GAD Detail
0.122 bipolar disorder An abnormal inverse pattern of insulin-GU and insulin-MoCA correlation was found... BeFree,CTD_human 25727318 Detail
0.001 Malignant neoplasm of urinary bladder NA BeFree Detail
0.120 Urinary Bladder Diseases NA CTD_human Detail
0.001 Brain Neoplasms NA BeFree Detail
0.047 Malignant neoplasm of breast Insulin resistance and inflammation may mediate the effects of central adiposity... BeFree,GAD 25056184 Detail
0.047 Malignant neoplasm of breast Insulin growth factor binding protein-5 (IGFBP-5) can show different effects on ... BeFree,GAD 25422220 Detail
0.047 Malignant neoplasm of breast The insulin-like growth factor type I receptor (IGF1R) is frequently dysregulate... BeFree,GAD 25465188 Detail
0.047 Malignant neoplasm of breast Epidemiologic studies have shown that diabetics receiving the biguanide metformi... BeFree,GAD 25681088 Detail
0.047 Malignant neoplasm of breast The role of the insulin-like growth factor-1 system in breast cancer. BeFree,GAD 25743390 Detail
0.047 Malignant neoplasm of breast Induction of anterior gradient 2 (AGR2) plays a key role in insulin-like growth ... BeFree,GAD 25956506 Detail
<0.001 bronchopulmonary dysplasia NA BeFree Detail
<0.001 Burkitt lymphoma NA BeFree Detail
<0.001 Cachexia NA BeFree Detail
0.006 Malignant tumor of colon In the present study we show that insulin reduced the 11beta-HSD2 activity in ca... BeFree 25133511 Detail
0.003 Malignant neoplasm of endometrium This study provides evidence to support a causal association of higher insulin l... BeFree 26134033 Detail
<0.001 Rectal Carcinoma Insulin-like growth factor receptor-1 overexpression is associated with poor res... BeFree 25473182 Detail
0.001 Malignant neoplasm of thyroid NA BeFree Detail
0.005 Non-small cell lung carcinoma Insulin-like growth factor (IGF)-dependent and -independent antitumor activities... BeFree 24942865 Detail
0.005 Non-small cell lung carcinoma Insulin-like growth factor (IGF) pathway has been suggested as a new molecular t... BeFree 25402559 Detail
Annotation

Annotations

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Body size, physical activity, early-life energy restriction, and associations with methylated insuli... DisGeNET Detail
Body size, physical activity, genetic variants in the insulin-like growth factor pathway and colorec... DisGeNET Detail
We investigated body size, physical activity, and early-life energy restriction in relation to color... DisGeNET Detail
The mechanistic effects of intravenous glucose, insulin and potassium (GIK) in cardiac ischemia are ... DisGeNET Detail
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Glucose derangements in CF seem to start from early infancy and, even when the pathophysiology is mu... DisGeNET Detail
Long-acting intranasal insulin detemir improves cognition for adults with mild cognitive impairment ... DisGeNET Detail
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These mutant proinsulin proteins accumulate in the endoplasmic reticulum (ER) and are poorly secrete... DisGeNET Detail
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To follow-up on the GWAS, tag SNPs across PFKFB2 were genotyped in American Indians (AI) who had lon... DisGeNET Detail
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Numerous reports suggest prominent vasoprotective effects of insulin growth factor binding protein-3... DisGeNET Detail
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The mechanisms may include the following pathways: [TGFB1 or TNFA]-[IL1B]-[pre-eclampsia]; [TNFA or ... DisGeNET Detail
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We hypothesized that functional polymorphisms in the insulin pathway genes INSR, insulin receptor su... DisGeNET Detail
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Maximal insulin response following arginine challenge was also significantly attenuated (iAUC HME: 7... DisGeNET Detail
We hypothesized that loss of function of EXT1 or EXT2 in subjects with hereditary multiple exostoses... DisGeNET Detail
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DBC1 KO mice fed a high-fat diet, although obese, remained insulin sensitive, had lower free fatty a... DisGeNET Detail
Insulin resistance and liver steatosis in chronic hepatitis C infection genotype 3. DisGeNET Detail
The present study clearly demonstrated that leptin improve fatty liver independently of insulin sens... DisGeNET Detail
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Fasting glucose, fasting insulin and random HbA1C were obtained in 158 patients with Friedreich atax... DisGeNET Detail
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Insulin Response Genes in Different Stages of Periodontal Disease. DisGeNET Detail
The mRNA expression patterns of genes that are associated with insulin response and glucose metaboli... DisGeNET Detail
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Insulin resistance is a recently investigated risk factor, and the risk of goitre may be reversible ... DisGeNET Detail
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Although the involvement of insulin-like signaling in cancer has been well documented in various typ... DisGeNET Detail
The baseline characteristics were: 73% men, 17% coinfected with hepatitis C virus and/or hepatitis B... DisGeNET Detail
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The baseline characteristics were: 73% men, 17% coinfected with hepatitis C virus and/or hepatitis B... DisGeNET Detail
To evaluate the expression of different insulin-like growth factor (IGF)-1 mRNA isoforms and IGF-1 r... DisGeNET Detail
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Insulin and IGF-1 improve mitochondrial function in a PI-3K/Akt-dependent manner and reduce mitochon... DisGeNET Detail
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Gestational diabetes mellitus (GDM) is recognized as an imbalance between insulin resistance and ins... DisGeNET Detail
Thus, impairment of insulin secretion leads to hyperglycemia and eventually causes diabetes. DisGeNET Detail
Chronic hyperglycaemia is associated with a dramatic reduction in insulin-positive cells and an incr... DisGeNET Detail
Progressive gain of beta-cell function occurs over 7 months, as measured by glucose-regulated insuli... DisGeNET Detail
These results indicate that high AR expression in the context of hyperglycemia and insulin deficienc... DisGeNET Detail
Diabetes mellitus (DM) is characterized by hyperglycemia, associated to a lack or inefficiency of th... DisGeNET Detail
Our results indicated the considerably aberrant MAPK signaling in both insulin-sensitive tissues of ... DisGeNET Detail
Insulin gene therapy, which has shown great efficacy in correcting hyperglycemia in animal models, h... DisGeNET Detail
Hyperglycemia in HNF-1α pregnancies is easily managed with current insulin protocols; in contrast, g... DisGeNET Detail
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Hyperinsulinemia initially presented in obese rats at 2 months (10.5 ± 0.7 μg/L plasma insulin vs. 0... DisGeNET Detail
Bioactives of Artemisia dracunculus L. (termed PMI 5011) have been shown to improve insulin action b... DisGeNET Detail
Moreover, expression of human apoB in fat-fed mice was associated with 32% (p = 0.02) and 37% (p = 0... DisGeNET Detail
ACE genotype and salt status do not impact on insulin sensitivity through changes in limb blood flow... DisGeNET Detail
PE cells co-cultured with islet cells or islet cell-derived conditioned medium (CM) showed increased... DisGeNET Detail
In diabetes, energy excess and prolonged hyperinsulinemia suppress muscle and adipose response to in... DisGeNET Detail
A gene trap insertion in Alms1 on the insulin sensitive C57BL6/Ei genetic background leads to early ... DisGeNET Detail
The hepatic iron content, serum iron parameters, and expressions of TFRs and IRPs in the liver were ... DisGeNET Detail
Insulin production and secretion appeared to be inhibited, suppressing the developing hyperinsulinem... DisGeNET Detail
Thiazolidinediones (TZDs), a class of antidiabetic drugs, act as insulin sensitizers increasing insu... DisGeNET Detail
In addition, anandamide has been shown to stimulate insulin secretion in vitro, suggesting that anan... DisGeNET Detail
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Insulin resistance, obesity, and hyperlipidemia (high lipid levels in the blood) have a strong conne... DisGeNET Detail
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Gβ3-deficient mice were normal as judged by body weight gain by age or by feeding with high-fat diet... DisGeNET Detail
This phenomenon, which may impair insulin secretion, has been suggested to be a reason for the adver... DisGeNET Detail
Preserved Na/HCO3 cotransporter sensitivity to insulin may promote hypertension in metabolic syndrom... DisGeNET Detail
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Congenital hyperinsulinism (CHI) is a rare metabolic disease characterized by inappropriate insulin ... DisGeNET Detail
Congenital hyperinsulinemic hypoglycemia (HI) is a heterogeneous genetic disorder of insulin secreti... DisGeNET Detail
Of note, 40% of people with HNF1A-MODY and medical treatment were receiving insulin alone and thus w... DisGeNET Detail
Loss-of-function abnormalities in cardiac Kir2.1 currents can lead to the long QT syndrome and alter... DisGeNET Detail
Both cases had normal levels of fasting plasma glucose (FPG), fasting hyperinsulinemia, low insulin ... DisGeNET Detail
Insulinomas are β-cell tumors that cause hypoglycemia through inappropriate secretion of insulin. DisGeNET Detail
Congenital hyperinsulinism (CHI) is a severe heterogeneous disorder due to dysregulation of insulin ... DisGeNET Detail
Insulin secretion becomes inappropriate for the level of blood glucose leading to severe hypoglycemi... DisGeNET Detail
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No patient was treated with insulin or had an insulinoma. DisGeNET Detail
In the 60-year-old female proband, hyperinsulinaemic hypoglycaemia (blood glucose 2·1 mmol/mol, insu... DisGeNET Detail
Examples of β-cell autoantigens are insulin, glutamic acid decarboxylase, tyrosine phosphatase, and ... DisGeNET Detail
Overexpression of angiotensin II type 2 receptor promotes apoptosis and impairs insulin secretion in... DisGeNET Detail
Characterization of the in vitro dynamics of insulin secretion by perifused fragments of 10 human in... DisGeNET Detail
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In our study, BMSCs were modified with insulin-like growth factor-1 (IGF-1) gene, loaded into a fibr... DisGeNET Detail
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In humans, inactivating mutations in GLUT2 cause Fanconi-Bickel syndrome, which is characterised by ... DisGeNET Detail
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As G protein estrogen receptor 1 (GPER1) mediates rapid cell responses to estrogens, we evaluated th... DisGeNET Detail
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Insulin growth factor 1 receptor expression is associated with NOTCH1 mutation, trisomy 12 and aggre... DisGeNET Detail
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In addition, recent study demonstrates AFB1 positively regulates type I insulin-like growth factor r... DisGeNET Detail
Furthermore, the investigation of extracellular matrix-related genes showed that genes like collagen... DisGeNET Detail
Insulin resistance (HOMA-IR) and glomerular filtration rate (GFR) were similar between control smoke... DisGeNET Detail
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Association between rs146052672 variant and MetS occurred independently of T2D, indicating that HMGA... DisGeNET Detail
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To study the expression of insulin-like growth factor binding proteins (IGFBPs) in paclitaxel-treate... DisGeNET Detail
Here, we reported significantly higher levels of serum insulin-like growth factor (IGF)-1 in GC pati... DisGeNET Detail
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This review discusses the role of NO in regulating adiposity and insulin sensitivity and places its ... DisGeNET Detail
The present review focuses on the role of aquaglyceroporins and caveolins on lipid and glucose metab... DisGeNET Detail
Type 1 diabetes (T1D) is a metabolic disease that results from the autoimmune attack against insulin... DisGeNET Detail
However, the role of adipocytes in linking energy metabolic disorders with insulin regulation is unk... DisGeNET Detail
Excessive secretion of the growth hormone (GH) leads to hepatic secretion of insulin-like growth fac... DisGeNET Detail
Results of this study demonstrate the dependence of insulin-like growth binding proteins as well as ... DisGeNET Detail
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In this study, we examined changes in gene expression profile in human mesenchymal stem cells (MSCs)... DisGeNET Detail
The serum levels of numerous cytokines (IL-1β, IL-12, IL-6, TNF-α, IFN-γ, IL-4, IL-10, and IL-17) se... DisGeNET Detail
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In this study, we evaluated the efficacy of intravenous administration of a recombinant adeno-associ... DisGeNET Detail
Recent evidence of IGF-1 axis alteration in spinal muscular atrophy (SMA), a very severe neurodegene... DisGeNET Detail
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Insulin-like growth factor-1 (IGF-1), a small protein/polypeptide with a short circulating-half life... DisGeNET Detail
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Elevated insulin levels have been associated with an increased cancer risk as well as with aggressiv... DisGeNET Detail
The importance of the insulin-like growth factor, IGF, as a signaling axis in cancer development, pr... DisGeNET Detail
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The major autopsy findings revealed hypertrophic cardiomyopathy, congenital myopathy, and a 1.4-cm p... DisGeNET Detail
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Maximal insulin response following arginine challenge was also significantly attenuated (iAUC HME: 7... DisGeNET Detail
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Pregnancy-associated plasma protein-A (PAPP-A) plays a key role in promoting insulin-like growth fac... DisGeNET Detail
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Three specific genes in the pain group overlap with sleep quality, including insulin-like growth fac... DisGeNET Detail
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Our studies establish important function of ida-1 as a modulator in Daf-2/Daf-16 insulin like signal... DisGeNET Detail
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Insulin Response Genes in Different Stages of Periodontal Disease. DisGeNET Detail
We conducted this study to examine whether insulin response genes are differentially expressed in gi... DisGeNET Detail
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A prospective study in 118 patients (mean age 47·7 ± 13·6 years, n = 52 women) undergoing insulin to... DisGeNET Detail
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Insulin resistance is a prominent feature of PCOS. DisGeNET Detail
Promoter SNPs of the HSD11B1 gene might exert a potential genetic protective role against the develo... DisGeNET Detail
All the PCOS had elevated body mass index, waist circumference, waist-to-hip ratio, fasting insulin,... DisGeNET Detail
Insulin resistance associated with abdominal obesity plays a leading role in the etiology of hyperan... DisGeNET Detail
The results from these studies demonstrate that the well-established abnormalities in insulin action... DisGeNET Detail
Association of insulin gene variable number of tandem repeats regulatory polymorphism with polycysti... DisGeNET Detail
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Compared with OCs, the PWS group had a decreased percentage of trunk FM and a better metabolic profi... DisGeNET Detail
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Examples of the latter include mGluR5 antagonists in FXS, mTOR inhibitors in TSC and insulin-like gr... DisGeNET Detail
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In the current study, in a lipopolysaccharide-based mouse model of ALI, we found that insulin allevi... DisGeNET Detail
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A multitude of molecular pathways well-described in carcinogenesis are regulated in part by TFE3 or ... DisGeNET Detail
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Interestingly, members of the miR-378 family presented as a possible target the insulin-like growth ... DisGeNET Detail
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These data re-emphasize the potential of the SjIRs as veterinary transmission blocking vaccine candi... DisGeNET Detail
The aim of our study was to investigate whether common polymorphisms in the genes regulating the ear... DisGeNET Detail
Evidence for disturbed insulin and growth hormone signaling as potential risk factors in the develop... DisGeNET Detail
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All patients presented with neonatal diabetes with a range of insulin sensitivities.Thyroid disease ... DisGeNET Detail
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Examples of the latter include mGluR5 antagonists in FXS, mTOR inhibitors in TSC and insulin-like gr... DisGeNET Detail
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The type I insulin-like growth factor receptor (IGF-IR) tyrosine kinase promotes the survival of an ... DisGeNET Detail
Recent evidence of IGF-1 axis alteration in spinal muscular atrophy (SMA), a very severe neurodegene... DisGeNET Detail
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The elevated GLP-1 levels in gestational diabetes women suggested some abnormality in insulin secret... DisGeNET Detail
The GDM pregnant women were treated by diet control or diet control and insulin injection. DisGeNET Detail
Increased hepatic lipid storage is an early abnormality in insulin resistant women with a history of... DisGeNET Detail
Insulin requires normal expression and signaling of insulin receptor A to reverse gestational diabet... DisGeNET Detail
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As 50% of patients with essential hypertension are insulin resistant and hyperinsulinemic, we hypoth... DisGeNET Detail
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The mechanistic effects of intravenous glucose, insulin and potassium (GIK) in cardiac ischemia are ... DisGeNET Detail
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This study suggests that acute gingival inflammation may induce localized changes that modify tissue... DisGeNET Detail
Neonatal diabetes in an infant of diabetic mother: same novel INS missense mutation in the mother an... DisGeNET Detail
In permanent neonatal diabetes (PNDM) patients, homozygous GCK (n=6), EIF2AK3 (n=3), PTF1A (n=3), an... DisGeNET Detail
A family with permanent neonatal diabetes due to a novel mutation in INS gene. DisGeNET Detail
We have previously shown that amino acid changes in the human Kruppel-Like Factor (KLF) 11 protein i... DisGeNET Detail
All patients presented with neonatal diabetes with a range of insulin sensitivities.Thyroid disease ... DisGeNET Detail
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Different nutritional deficiencies such as a low availability of proteins in the maternal diet produ... DisGeNET Detail
Malnutrition in the elderly is accompanied by several metabolic dysfunctions, especially alterations... DisGeNET Detail
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Altogether, our data indicate that GPER1 may be included among the complex network of transduction s... DisGeNET Detail
We report a peculiar case of a GCK/MODY2 family in whom monogenic and autoimmune diabetes coexist an... DisGeNET Detail
Currently, there is no treatment to restore endogenous insulin secretion in patients with autoimmune... DisGeNET Detail
Materno-Fetal Transfer of Preproinsulin Through the Neonatal Fc Receptor Prevents Autoimmune Diabete... DisGeNET Detail
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Insulin resistance associated with abdominal obesity plays a leading role in the etiology of hyperan... DisGeNET Detail
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Finally, the accelerated cellular senescence was also observed at the organismal level as shown by d... DisGeNET Detail
Different nutritional deficiencies such as a low availability of proteins in the maternal diet produ... DisGeNET Detail
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Liposomal insulin promoter-thymidine kinase gene therapy followed by ganciclovir effectively ablates... DisGeNET Detail
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Here we investigated the role of Alms1 disruption in AT expansion and insulin responsiveness in a mu... DisGeNET Detail
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Neonatal diabetes in an infant of diabetic mother: same novel INS missense mutation in the mother an... DisGeNET Detail
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Complete and partial GHD were defined as peak GH responses of 5 and 7 μg/l (15 and 21 mIU/l) [IRMA/D... DisGeNET Detail
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NUCKS knockout mice exhibit decreased insulin signaling and increased body weight/fat mass along wit... DisGeNET Detail
Furthermore, other than its established role in regulating insulin secretion by β-cells, evidence is... DisGeNET Detail
Insulin resistance, a hallmark of impaired glucose tolerance and type 2 diabetes (T2D), arises from ... DisGeNET Detail
Here, we demonstrate that with progressive age, skeletal muscle-specific TWEAK-transgenic (TWEAK-Tg)... DisGeNET Detail
Thus, overexpression of human IGFBP-3 or its mutant devoid of IGF binding ability leads to glucose i... DisGeNET Detail
We have identified significant behavioural deficits, together with a degree of glucose intolerance a... DisGeNET Detail
Maternal alcohol intake around the time of conception causes glucose intolerance and insulin insensi... DisGeNET Detail
Adult Tshz1(+/-) mice display glucose intolerance due to defects in glucose-stimulated insulin secre... DisGeNET Detail
HFD-fed GPR43 knockout (KO) mice develop glucose intolerance due to a defect in insulin secretion. DisGeNET Detail
Moreover, islet-specific Senp1 deletion in mice caused impaired glucose tolerance by reducing the am... DisGeNET Detail
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Insulin resistance associated with abdominal obesity plays a leading role in the etiology of hyperan... DisGeNET Detail
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Genetic testing for maturity-onset diabetes of the young (MODY) may be relevant for treatment and pr... DisGeNET Detail
The mean centroid of gene expression of T2DM and MODY pathways was shown to be associated positively... DisGeNET Detail
Structural and functional study of the GlnB22-insulin mutant responsible for maturity-onset diabetes... DisGeNET Detail
Frameshift mutations in the insulin gene leading to prolonged molecule of insulin in two families wi... DisGeNET Detail
We have previously shown that amino acid changes in the human Kruppel-Like Factor (KLF) 11 protein i... DisGeNET Detail
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Liposomal insulin promoter-thymidine kinase gene therapy followed by ganciclovir effectively ablates... DisGeNET Detail
Elevated insulin levels have been associated with an increased cancer risk as well as with aggressiv... DisGeNET Detail
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There is a growing interest in food constituents that could reduce intestinal glucose absorption to ... DisGeNET Detail
In contrast, in pre-diabetic conditions, reduced oxidative capacity, high levels of reactive oxygen ... DisGeNET Detail
Insulin levels (mRNA/protein) were higher in AT derived from prediabetes BB rats with destructed pan... DisGeNET Detail
The aim of our study was to investigate associations between these novel risk variants and type 2 di... DisGeNET Detail
Genetic variation at insulin-like growth factor 1 (IGF1) has been linked to prostate cancer risk. DisGeNET Detail
Inhibition of the mitogenic insulin-like growth factor receptor 1 (IGF-1R) signaling axis is a compe... DisGeNET Detail
The insulin-like growth factor (IGF)/Akt signaling pathway appears to be the key pathway moderating ... DisGeNET Detail
The insulin-like growth factor (IGF) axis as an anticancer target in prostate cancer. DisGeNET Detail
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A 3 year old patient with NDM diagnosed at 3 months of age, who previously tested negative for INS, ... DisGeNET Detail
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As metformin can inhibit endometrial carcinoma (EC) cell growth and the insulin growth factor (IGF) ... DisGeNET Detail
This study provides evidence to support a causal association of higher insulin levels, independently... DisGeNET Detail
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Long-acting intranasal insulin detemir improves cognition for adults with mild cognitive impairment ... DisGeNET Detail
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Insulin-sensitizing thiazolidinediones exert a pleiotropic pharmacology with therapeutic potential i... DisGeNET Detail
Effect of dietary fat modification on subcutaneous white adipose tissue insulin sensitivity in patie... DisGeNET Detail
Association of common genetic variants with diabetes and metabolic syndrome related traits in the Ar... DisGeNET Detail
Insulin resistance (IR) is a distinct and early feature of type 2 diabetes mellitus and metabolic sy... DisGeNET Detail
We also discuss relevant issues such as the role of leptin, insulin and renin-angiotensin signaling ... DisGeNET Detail
Plasma EETs correlated with insulin sensitivity index (r=0.64, p=0.015 for total EETs) and were decr... DisGeNET Detail
Insulin resistance is a major hallmark of metabolic syndromes, including Type 2 diabetes. DisGeNET Detail
Preserved Na/HCO3 cotransporter sensitivity to insulin may promote hypertension in metabolic syndrom... DisGeNET Detail
Regression analysis showed significant correlation of body mass index, waist and hip circumference, ... DisGeNET Detail
A LGI diet, particularly associated with the use of Policaptil Gel Retard, may reduce weight gain an... DisGeNET Detail
We investigated the association of various lipoprotein traits, apolipoproteins and their ratios with... DisGeNET Detail
After further adjustment for the adiponectin levels, participants with a minor allele of rs12051272 ... DisGeNET Detail
In addition this SNP may play a role in the development of cardiovascular diseases and metabolic syn... DisGeNET Detail
Important inconsistencies have emerged recently regarding the role of insulin-like signalling and th... DisGeNET Detail
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Insulin resistance (IR) affects sustained virological response (SVR) to peginterferon alfa plus riba... DisGeNET Detail
Insulin resistance, adipokine profile and hepatic expression of SOCS-3 gene in chronic hepatitis C. DisGeNET Detail
Insulin resistance and liver steatosis in chronic hepatitis C infection genotype 3. DisGeNET Detail
Insulin-like growth factor-1 mRNA isoforms and insulin-like growth factor-1 receptor mRNA expression... DisGeNET Detail
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MC4R variants were detected in three patients: the known I169S variant was found in heterozygote sta... DisGeNET Detail
MC4R variants were detected in three patients: the known I169S variant was found in heterozygote sta... DisGeNET Detail
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Significant improvements in classical and emerging CVD risk factors also supported a favorable effec... DisGeNET Detail
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The E23K polymorphism of the pancreatic beta-cell ATP-sensitive K(+) (K(ATP)) channel subunit Kir6.2... DisGeNET Detail
The E23K variant of Kir6.2 associates with impaired post-OGTT serum insulin response and increased r... DisGeNET Detail
The E23K polymorphism of the pancreatic beta-cell ATP-sensitive K(+) (K(ATP)) channel subunit Kir6.2... DisGeNET Detail
We conclude that the lysine variant in KCNJ11 E23K leads to diminished insulin secretion in individu... DisGeNET Detail
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Insulin-like growth factors (IGFs) can promote tumorigenesis via inhibiting the apoptosis of cancer ... DisGeNET Detail
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Forty-nine patients, with schizophrenia or schizoaffective disorder and treated with clozapine (n = ... DisGeNET Detail
Genetic variation at insulin-like growth factor 1 (IGF1) has been linked to prostate cancer risk. DisGeNET Detail
Inhibition of the mitogenic insulin-like growth factor receptor 1 (IGF-1R) signaling axis is a compe... DisGeNET Detail
The insulin-like growth factor (IGF)/Akt signaling pathway appears to be the key pathway moderating ... DisGeNET Detail
The insulin-like growth factor (IGF) axis as an anticancer target in prostate cancer. DisGeNET Detail
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Type 2 diabetes mellitus (T2DM) is a progressive disease resulting from increasing insulin resistanc... DisGeNET Detail
Insulin resistance and inflammation may mediate the effects of central adiposity on mortality among ... DisGeNET Detail
Insulin growth factor binding protein-5 (IGFBP-5) can show different effects on apoptosis, cell moti... DisGeNET Detail
The insulin-like growth factor type I receptor (IGF1R) is frequently dysregulated in breast cancers,... DisGeNET Detail
Epidemiologic studies have shown that diabetics receiving the biguanide metformin, as compared with ... DisGeNET Detail
The role of the insulin-like growth factor-1 system in breast cancer. DisGeNET Detail
Induction of anterior gradient 2 (AGR2) plays a key role in insulin-like growth factor-1 (IGF-1)-ind... DisGeNET Detail
Expression of the JAK2 V617F mutant renders Ba/F3 cells hypersensitive to insulin-like growth factor... DisGeNET Detail
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To study the expression of insulin-like growth factor binding proteins (IGFBPs) in paclitaxel-treate... DisGeNET Detail
Here, we reported significantly higher levels of serum insulin-like growth factor (IGF)-1 in GC pati... DisGeNET Detail
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To evaluate the possible role of insulin-like growth factor (IGF)-1 in acne vulgaris (AV) pathogenes... DisGeNET Detail
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Genetic markers of insulin sensitivity and insulin secretion are associated with spontaneous postnat... DisGeNET Detail
SHOX gene variants: growth hormone/insulin-like growth factor-1 status and response to growth hormon... DisGeNET Detail
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Group C (three patients with fasting hypoglycemic episodes) displayed very low rates of insulin secr... DisGeNET Detail
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Therefore, multiple defects in insulin and glucose metabolism are required for DM to occur in indivi... DisGeNET Detail
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Insulin autoimmune syndrome (IAS, Hirata disease) is a rare cause of spontaneous hypoglycaemia, extr... DisGeNET Detail
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Pregnancy-associated plasma protein-A (PAPP-A) plays a key role in promoting insulin-like growth fac... DisGeNET Detail
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Expression levels of insulin-like growth factors 1 and 2 in head and neck squamous cell carcinoma. DisGeNET Detail
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Alterations in insulin stimulated trafficking of glucose transporter 4 are an early sign of metaboli... DisGeNET Detail
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Type II diabetes mellitus (T2D) is a chronic metabolic disorder that results from defects in both in... DisGeNET Detail
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Intranasal (IN) insulin acutely improves verbal memory in mild cognitive impairment (MCI)/Alzheimer'... DisGeNET Detail
Long-acting intranasal insulin detemir improves cognition for adults with mild cognitive impairment ... DisGeNET Detail
Association of insulin-like growth factor-1 with mild cognitive impairment and slow gait speed. DisGeNET Detail
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Insulin resistance, selfish brain, and selfish immune system: an evolutionarily positively selected ... DisGeNET Detail
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Inhibition of type I insulin-like growth factor receptor tyrosine kinase by picropodophyllin induces... DisGeNET Detail
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Co-expression of both c-kit and KRAS, typical markers for CSC with overlapping with insulin in islet... DisGeNET Detail
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Body size, physical activity, early-life energy restriction, and associations with methylated insuli... DisGeNET Detail
Body size, physical activity, genetic variants in the insulin-like growth factor pathway and colorec... DisGeNET Detail
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Important mechanisms we discuss include (1) improved DNA repair in normal, but not tumor cells; (2) ... DisGeNET Detail
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A variable phenotype was associated with the homozygous c.-331C>A INS mutation, which was identified... DisGeNET Detail
We report four cases of PNDM.None of the infants or their parents had INS, KCNJ11, or ABCC8 genetic ... DisGeNET Detail
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This study provides evidence to support a causal association of higher insulin levels, independently... DisGeNET Detail
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Although the involvement of insulin-like signaling in cancer has been well documented in various typ... DisGeNET Detail
In the present study, we report a novel insulin-like growth factor 1 (IGF1) pathway that mediates de... DisGeNET Detail
To unravel the role of interleukin (IL)-6 and insulin-like growth factor (IGF)-I receptor (IGFIR) in... DisGeNET Detail
As the insulin-like growth factor (IGF) axis is a highly tumorigenic pathway in HCC, the present stu... DisGeNET Detail
In addition, recent study demonstrates AFB1 positively regulates type I insulin-like growth factor r... DisGeNET Detail
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Insulin resistance may develop in early stage of childhood obesity and in very young children may be... DisGeNET Detail
Studies examining vitamin D levels in association with childhood obesity usually do not consider the... DisGeNET Detail
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DBC1 KO mice fed a high-fat diet, although obese, remained insulin sensitive, had lower free fatty a... DisGeNET Detail
Insulin resistance and liver steatosis in chronic hepatitis C infection genotype 3. DisGeNET Detail
Hepatocyte Nicotinamide Adenine Dinucleotide Phosphate Reduced Oxidase 4 Regulates Stress Signaling,... DisGeNET Detail
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Inhibitors of NOX4 reduce liver inflammation and fibrosis and increase insulin sensitivity, and migh... DisGeNET Detail
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Type 2 diabetes mellitus (T2DM) is a progressive disease resulting from increasing insulin resistanc... DisGeNET Detail
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To evaluate the possible role of insulin-like growth factor (IGF)-1 in acne vulgaris (AV) pathogenes... DisGeNET Detail
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We also discuss relevant issues such as the role of leptin, insulin and renin-angiotensin signaling ... DisGeNET Detail
Insulin resistance and type 2 diabetes are associated with clinical Alzheimer's disease, whereas stu... DisGeNET Detail
D2M is linked with Alzheimer's disease through deregulation of calcium ions thereby leading to metab... DisGeNET Detail
A regulatory role for the insulin- and BDNF-linked RORA in the hippocampus: implications for Alzheim... DisGeNET Detail
A single-dose pilot trial of intranasal rapid-acting insulin in apolipoprotein E4 carriers with mild... DisGeNET Detail
Long-acting intranasal insulin detemir improves cognition for adults with mild cognitive impairment ... DisGeNET Detail
The decrease in serum insulin-like growth factor-1 (IGF-I) with aging is related to the neurobiologi... DisGeNET Detail
Partial Loss of the Glutamate Transporter GLT-1 Alters Brain Akt and Insulin Signaling in a Mouse Mo... DisGeNET Detail
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Insulin resistance aggravates atherosclerosis by reducing vascular smooth muscle cell survival and i... DisGeNET Detail
Inhibition of the insulin-like growth factor system is a potential therapy for rheumatoid arthritis. DisGeNET Detail
These findings suggest that insulin/IRS-1 signaling is important in the pathogenesis of RA. DisGeNET Detail
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Insulin resistance aggravates atherosclerosis by reducing vascular smooth muscle cell survival and i... DisGeNET Detail
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Diabetes mellitus type 1 (DM1) is an autoimmune disease that gradually destroys insulin-producing be... DisGeNET Detail
Type 1 diabetes (T1D) is an autoimmune disease which is caused by destruction of insulin producing β... DisGeNET Detail
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An abnormal inverse pattern of insulin-GU and insulin-MoCA correlation was found in BD-pairs. DisGeNET Detail
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Insulin resistance and inflammation may mediate the effects of central adiposity on mortality among ... DisGeNET Detail
Insulin growth factor binding protein-5 (IGFBP-5) can show different effects on apoptosis, cell moti... DisGeNET Detail
The insulin-like growth factor type I receptor (IGF1R) is frequently dysregulated in breast cancers,... DisGeNET Detail
Epidemiologic studies have shown that diabetics receiving the biguanide metformin, as compared with ... DisGeNET Detail
The role of the insulin-like growth factor-1 system in breast cancer. DisGeNET Detail
Induction of anterior gradient 2 (AGR2) plays a key role in insulin-like growth factor-1 (IGF-1)-ind... DisGeNET Detail
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In the present study we show that insulin reduced the 11beta-HSD2 activity in cancer colon cell line... DisGeNET Detail
This study provides evidence to support a causal association of higher insulin levels, independently... DisGeNET Detail
Insulin-like growth factor receptor-1 overexpression is associated with poor response of rectal canc... DisGeNET Detail
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Insulin-like growth factor (IGF)-dependent and -independent antitumor activities of insulin-like gro... DisGeNET Detail
Insulin-like growth factor (IGF) pathway has been suggested as a new molecular target for the treatm... DisGeNET Detail

Overlapped Transcript Coordinates

Gene Transcript ID Exon Number Chromosome Start Stop Type Amino Mutation Transcript Position Links

Overlapped Transcript

Gene Transcript ID Chromosome Start Stop Links
Gene
-
dbSNP
rs146052672 dbSNP
Genome
hg19
Position
chr11:2,181,009-2,182,451
Variant Type
snv
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