retinitis pigmentosa
Information
- Disease name
- retinitis pigmentosa
- Disease ID
- DOID:10584
- Description
- "A retinal degeneration characterized by the gradual deterioration of the photoreceptors or the retinal pigment epithelium of the retina leading to progressive sight loss." [url:http\://en.wikipedia.org/wiki/Retinitis_pigmentosa, url:http\://ghr.nlm.nih.gov/condition/retinitis-pigmentosa, url:http\://www.ncbi.nlm.nih.gov/pmc/articles/PMC4043609/, url:https\://www.genome.gov/Genetic-Disorders/Retinitis-Pigmentosa]
Disease area statistics
Chromosome band
| Gene symbol | Chromosome | Start | Stop | The number of variant |
|---|---|---|---|---|
| EYS | 6 | 63,720,136 | 65,707,214 | 32 |
| USH2A | 1 | 215,622,891 | 216,423,448 | 26 |
| RDH12 | 14 | 67,701,886 | 67,734,451 | 16 |
| CFAP410 | 21 | 44,329,891 | 44,339,393 | 12 |
| RPGR | X | 38,284,408 | 38,327,509 | 10 |
| PDE6B | 4 | 625,573 | 670,782 | 10 |
| RHO | 3 | 129,528,639 | 129,535,344 | 10 |
| CNGA1 | 4 | 47,935,977 | 48,016,681 | 8 |
| PRPF31 | 19 | 54,115,754 | 54,131,713 | 6 |
| MERTK | 2 | 111,898,607 | 112,029,561 | 6 |
Annotation
| Genes | Mutation | Description | Source | Links |
|---|
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT04285398 | Active, not recruiting | N/A | Prospective Natural History Study of Retinitis Pigmentosa | February 12, 2020 | June 30, 2026 |
| NCT01680510 | Active, not recruiting | Phase 1/Phase 2 | The Effect of Oral Administration of 9-cis β Carotene Rich Powder of the Alga Dunaliella Bardawil | September 1, 2012 | December 31, 2025 |
| NCT01736059 | Active, not recruiting | Phase 1 | Clinical Trial of Autologous Intravitreal Bone-marrow CD34+ Stem Cells for Retinopathy | July 2012 | October 2025 |
| NCT02464436 | Active, not recruiting | Phase 1/Phase 2 | Safety and Tolerability of hRPC in Retinitis Pigmentosa | December 2015 | December 2023 |
| NCT03999021 | Active, not recruiting | Phase 1 | FIGHT-RP 1 Extension Study | June 24, 2019 | June 2027 |
| NCT04765345 | Active, not recruiting | Rate of Progression of PCDH15-Related Retinal Degeneration in Usher Syndrome 1F | June 8, 2021 | April 1, 2025 | |
| NCT05392751 | Active, not recruiting | Phase 1/Phase 2 | Dose Escalation Study to Evaluate the Safety/Tolerability and Efficacy of EA-2353 in Subjects With Retinitis Pigmentosa | June 2, 2022 | June 30, 2025 |
| NCT00378742 | Active, not recruiting | Repository for Inherited Eye Diseases | September 20, 2006 | ||
| NCT03963154 | Active, not recruiting | Phase 1/Phase 2 | Interventional Study of Implantation of hESC-derived RPE in Patients With RP Due to Monogenic Mutation | August 19, 2019 | December 15, 2026 |
| NCT02086890 | Active, not recruiting | N/A | Electro-acupuncture and Transcorneal Electrical Stimulation (TES) for Retinitis Pigmentosa | August 2014 | December 2024 |
| NCT03349242 | Active, not recruiting | Natural History Study of Patients With X-linked Retinal Dystrophy Associated With Mutations in Retinitis Pigmentosa GTPase Regulator (RPGR) | December 19, 2017 | May 31, 2024 | |
| NCT04127006 | Active, not recruiting | Rate of Progression in EYS Related Retinal Degeneration | February 25, 2020 | December 2025 | |
| NCT04611503 | Active, not recruiting | Phase 1/Phase 2 | PDE6A Gene Therapy for Retinitis Pigmentosa | September 24, 2019 | July 2027 |
| NCT05158296 | Active, not recruiting | Phase 2/Phase 3 | Study to Evaluate the Efficacy Safety and Tolerability of Ultevursen in Subjects With RP Due to Mutations in Exon 13 of the USH2A Gene (Sirius) | December 8, 2021 | December 2024 |
| NCT04356716 | Active, not recruiting | Phase 2 | Sildenafil for Treatment of Choroidal Ischemia | November 11, 2014 | December 2024 |
| NCT03374657 | Active, not recruiting | Phase 1/Phase 2 | A First-in-human, Proof of Concept Study of CPK850 in Patients With RLBP1 Retinitis Pigmentosa | August 22, 2018 | May 11, 2026 |
| NCT05820100 | Completed | Observational Study to Assess the Reliability and Validity of the MLYMT and MLSDT | April 25, 2023 | October 17, 2023 | |
| NCT00461435 | Completed | N/A | Slowing the Degenerative Process, Long Lasting Effect of Hyperbaric Oxygen Therapy in Retinitis Pigmentosa | ||
| NCT00475254 | Completed | Stress and Vision Fluctuations in Retinitis Pigmentosa | August 2007 | April 2011 | |
| NCT00515814 | Completed | N/A | Retina Implant Pilot Trial to Evaluate Safety & Efficacy in Blind Patients Having Degenerated Photo-receptors | September 2005 | December 2009 |
| NCT00559234 | Completed | Potential Research Participants for Future Studies of Inherited Eye Diseases | November 9, 2007 | October 3, 2008 | |
| NCT00661479 | Completed | Phase 1/Phase 2 | An Exploratory Study to Evaluate the Safety of Brimonidine Intravitreal Implant in Patients With Retinitis Pigmentosa | July 2008 | May 2010 |
| NCT00717080 | Completed | Phase 4 | The Role of Capsular Tension Ring (CTR) in Anterior Capsular Contraction | July 2008 | June 2010 |
| NCT00784901 | Completed | Study of the Correlation Between Macular Thickness Analyzed by Optical Coherence Tomography and the Visual Functions in Retinitis Pigmemtosa | August 2008 | November 2008 | |
| NCT00804102 | Completed | N/A | Transcorneal Electrical Stimulation Therapy for Retinal Disease | January 2008 | April 2011 |
| NCT01021982 | Completed | Evaluation of Objective Perimetry Using Pupillometer | November 2009 | January 2013 | |
| NCT01024803 | Completed | N/A | Safety and Efficacy of Subretinal Implants for Partial Restoration of Vision in Blind Patients | December 2009 | April 2018 |
| NCT01068561 | Completed | Phase 1 | Autologous Bone Marrow-Derived Stem Cells Transplantation For Retinitis Pigmentosa | May 2009 | February 2010 |
| NCT01233609 | Completed | Phase 2 | Trial of Oral Valproic Acid for Retinitis Pigmentosa | November 2010 | December 2015 |
| NCT01256697 | Completed | N/A | The Effect of Oral Administration of 9-cis Rich Powder of the Alga Dunaliella Bardawil on Visual Functions im Patients With Retinitis Pigmentosa | August 2008 | January 2011 |
| NCT01399515 | Completed | Phase 2 | Efficacy and Safety of Oral Valproic Acid for Retinitis Pigmentosa | March 2011 | November 2015 |
| NCT05800301 | Completed | Phase 3 | Management of Retinitis Pigmentosa Via Combination of Wharton's Jelly-derived Mesenchymal Stem Cells and Magnovision | January 1, 2019 | December 31, 2022 |
| NCT01482195 | Completed | Phase 1 | Trial of Subretinal Injection of (rAAV2-VMD2-hMERTK) | August 2011 | August 2019 |
| NCT05712148 | Completed | Phase 1/Phase 2 | Spheroidal Mesenchymal Stem Cells in Retinitis Pigmentosa | October 11, 2019 | June 14, 2022 |
| NCT01497379 | Completed | N/A | Safety & Efficacy of Subretinal Implants for Partial Restoration of Vision in Blind Patients | October 2011 | January 2015 |
| NCT01530659 | Completed | Phase 2 | Retinal Imaging in CNTF -Releasing Encapsulated Cell Implant Treated Patients for Early-stage Retinitis Pigmentosa | January 2012 | July 1, 2019 |
| NCT01531348 | Completed | Phase 1 | Intravitreal Injection of MSCs in Retinitis Pigmentosa | April 2012 | July 2020 |
| NCT01560715 | Completed | Phase 2 | Autologous Bone Marrow-Derived Stem Cells Transplantation For Retinitis Pigmentosa | June 2011 | June 2013 |
| NCT01603576 | Completed | N/A | Pilot Study of a Suprachoroidal Retinal Prosthesis | May 2012 | August 2014 |
| NCT01604356 | Completed | Phase 1 | Acupuncture for the Treatment of Vision Loss Due to Retinitis Pigmentosa | April 2012 | December 2013 |
| NCT05392179 | Completed | Phase 2 | A Study in Subjects With Retinitis Pigmentosa | July 14, 2022 | June 23, 2023 |
| NCT01790958 | Completed | Microcurrent Stimulation to Treat Macular Degeneration | June 2012 | December 2012 | |
| NCT05285618 | Completed | N/A | The Perceptual Experience of Argus II Users | January 11, 2022 | August 31, 2023 |
| NCT01835002 | Completed | N/A | Transcorneal Electrical Stimulation - Multicenter Safety Study | September 2012 | August 2015 |
| NCT01837901 | Completed | N/A | Transcorneal Electrostimulation for Therapy of Retinitis Pigmentosa | July 2011 | February 2014 |
| NCT01847365 | Completed | N/A | TES for the Treatment of RP | April 2013 | February 2015 |
| NCT01864486 | Completed | N/A | Restoring Vision With the Intelligent Retinal Implant System (IRIS V1)in Patients With Retinal Dystrophy | April 2013 | October 13, 2017 |
| NCT01876147 | Completed | Visual and Functional Assessment in Low Vision Patients | August 2013 | March 2016 | |
| NCT04983914 | Completed | Retrospective NIS to Evaluate the Patient Benefit of TES | September 6, 2021 | August 19, 2022 | |
| NCT01949623 | Completed | Biomarkers In Retinitis Pigmentosa (BIRP) | September 2013 | July 2017 | |
| NCT04945772 | Completed | Phase 2 | Efficacy and Safety of MCO-010 Optogenetic Therapy in Adults With Retinitis Pigmentosa [RESTORE] | July 13, 2021 | January 18, 2024 |
| NCT04925687 | Completed | Phase 1 | Phase 1 Study of Intravitreal Autologous CD34+ Stem Cell Therapy for Retinitis Pigmentosa | June 1, 2021 | November 1, 2023 |
| NCT00000116 | Completed | Phase 3 | Randomized Trial of DHA for Retinitis Pigmentosa Patients Receiving Vitamin A | May 1996 | September 2002 |
| NCT02110225 | Completed | Phase 1/Phase 2 | A Dose Ranging Study to Evaluate the Safety and Potential Efficacy of rhNGF in Patients With Retinitis Pigmentosa (RP) | January 2014 | November 2015 |
| NCT02140164 | Completed | Phase 1/Phase 2 | Study of Oral Minocycline in Treating Bilateral Cystoid Macular Edema Associated With Retinitis Pigmentosa | May 2014 | June 2016 |
| NCT02244996 | Completed | N/A | Cone Rescue in Retinitis Pigmentosa by the Treatment of Lycium Barbarum | November 2014 | November 2017 |
| NCT02280135 | Completed | Phase 1 | Clinical Trial of Intravitreal Injection of Autologous Bone Marrow Stem Cells in Patients With Retinitis Pigmentosa | November 2014 | March 2017 |
| NCT02303288 | Completed | Post-Market Study of the Argus® II Retinal Prosthesis System - France | November 20, 2014 | November 20, 2018 | |
| NCT04919473 | Completed | Phase 1/Phase 2 | Dose-Escalation Study to Evaluate the Safety and Tolerability of Intravitreal vMCO-I in Patients With Advanced Retinitis Pigmentosa | October 23, 2019 | October 31, 2020 |
| NCT04909398 | Completed | N/A | Pupil Dynamics and Color Vision for the Detection of Eye Diseases | March 22, 2018 | May 22, 2019 |
| NCT00001347 | Completed | Study of Usher Syndromes, Type 1 and Type 2 | June 1993 | August 2002 | |
| NCT04723160 | Completed | Computer Aided Diagnosis of Multiple Eye Fundus Diseases From Color Fundus Photograph | August 10, 2020 | May 30, 2021 | |
| NCT02609165 | Completed | Phase 2 | Nerve Growth Factor Eye Drops Treatment in Patients With Retinitis Pigmentosa and Cystoid Macular Edema | May 2015 | February 2017 |
| NCT02614651 | Completed | N/A | AUgmented REality for the Visually Impaired - Part 1 | May 2016 | May 29, 2017 |
| NCT04636853 | Completed | Phase 3 | CB-PRP in Retinitis Pigmentosa and Dry Age-related Macular Degeneration | December 23, 2020 | December 2, 2021 |
| NCT02661711 | Completed | Phase 2 | Aflibercept for Macular Oedema With Underlying Retinitis Pigmentosa (AMOUR) Study | March 2016 | October 2017 |
| NCT02670980 | Completed | N/A | Compensation for Blindness With the Intelligent Retinal Implant System (IRIS V2) in Patients With Retinal Dystrophy | January 2016 | May 2019 |
| NCT02720640 | Completed | N/A | Safety and Efficacy of the Alpha AMS Subretinal Implant | May 2015 | October 2017 |
| NCT04604899 | Completed | Phase 2 | Safety of Repeat Intravitreal Injection of Human Retinal Progenitor Cells (jCell) in Adult Subjects With Retinitis Pigmentosa | December 1, 2020 | March 22, 2022 |
| NCT03901391 | Completed | Prospective Open Clinical and Genetic Study of Patients With Retinitis Pigmentosa | March 26, 2019 | October 20, 2020 | |
| NCT00000114 | Completed | Phase 3 | Randomized Trial of Vitamin A and Vitamin E Supplementation for Retinitis Pigmentosa | May 1984 | June 1987 |
| NCT00004827 | Completed | N/A | Study of Docosahexaenoic Acid (DHA) Supplementation in Patients With X-Linked Retinitis Pigmentosa | March 1996 | June 2002 |
| NCT00016471 | Completed | A Genetic Analysis of Usher Syndrome in Ashkenazi Jews | March 2001 | February 2002 | |
| NCT00029289 | Completed | Phase 1/Phase 2 | Effects of Lutein in Retinitis Pigmentosa | April 2001 | October 2002 |
| NCT00063765 | Completed | Phase 1 | Evaluation of Safety of Ciliary Neurotrophic Factor Implants in the Eye | June 2003 | March 2006 |
| NCT00065455 | Completed | Phase 1 | Investigating the Effect of Vitamin A Supplementation on Retinitis Pigmentosa | July 17, 2003 | May 6, 2009 |
| NCT00100230 | Completed | Phase 2 | DHA and X-Linked Retinitis Pigmentosa | September 2004 | August 2014 |
| NCT00106743 | Completed | Natural History and Genetic Studies of Usher Syndrome | March 21, 2005 | April 30, 2019 | |
| NCT00231010 | Completed | Molecular Genetics of Retinal Degenerations | September 26, 2005 | June 23, 2016 | |
| NCT06368375 | Completed | Clinical and Genetic Findings in Patients With PRPF31-associated Retinitis Pigmentosa | January 1, 2023 | June 30, 2023 | |
| NCT00279500 | Completed | N/A | Feasibility Study of a Chronic Retinal Stimulator in Retinitis Pigmentosa | February 27, 2002 | December 31, 2014 |
| NCT00346333 | Completed | Phase 3 | Clinical Trial of Lutein for Patients With Retinitis Pigmentosa Receiving Vitamin A | July 2003 | December 2008 |
| NCT00407602 | Completed | N/A | Argus® II Retinal Stimulation System Feasibility Protocol | September 2006 | December 31, 2019 |
| NCT00447980 | Completed | Phase 2 | A Study of Encapsulated Cell Technology (ECT) Implant for Participants With Early Stage Retinitis Pigmentosa | January 2007 | July 2010 |
| NCT00447993 | Completed | Phase 2 | A Study of Encapsulated Cell Technology (ECT) Implant for Patients With Late Stage Retinitis Pigmentosa | January 2007 | October 2009 |
| NCT04224207 | Completed | Phase 3 | Management of Retinitis Pigmentosa by Mesenchymal Stem Cells by Wharton's Jelly Derived Mesenchymal Stem Cells | April 1, 2019 | January 1, 2020 |
| NCT04141891 | Completed | N/A | Advancing Understanding of Transportation Options | December 12, 2019 | December 21, 2023 |
| NCT03780257 | Completed | Phase 1/Phase 2 | Study to Evaluate Safety and Tolerability of QR-421a in Subjects With RP Due to Mutations in Exon 13 of the USH2A Gene | March 6, 2019 | October 14, 2021 |
| NCT04068207 | Completed | Phase 2 | Minocycline Treatment in Retinitis Pigmentosa | August 25, 2019 | December 1, 2023 |
| NCT04008771 | Completed | N/A | Intravitreal Injection of SeeQ CdSe 655 Alt Nanoparticles for Patients With Degenerative Retinal Diseases | January 6, 2014 | December 19, 2014 |
| NCT04319809 | Completed | N/A | Object Finder for a Retinal Prosthesis | July 1, 2017 | August 31, 2022 |
| NCT02909985 | Completed | N/A | Visual Activity Evoked by Infrared in Humans After Dark Adaptation | September 2015 | August 2016 |
| NCT04315025 | Completed | Phase 1/Phase 2 | Safety Issues of Peribulbar Injection of UC-MSC in Patients With Retinitis Pigmentosa | October 7, 2018 | September 20, 2019 |
| NCT03057496 | Completed | N/A | Collision Warning Device for Blind and Visually Impaired | January 22, 2018 | December 5, 2019 |
| NCT03063021 | Completed | Phase 1 | The FIGHT-RP1 Study | February 15, 2017 | February 11, 2019 |
| NCT03073733 | Completed | Phase 2 | Safety and Efficacy of Intravitreal Injection of Human Retinal Progenitor Cells in Adults With Retinitis Pigmentosa | March 1, 2017 | November 13, 2020 |
| NCT04252534 | Completed | N/A | Management of Retinitis Pigmentosa Via Electromagnetic Stimulation and Platelet Rich Plasma | January 1, 2017 | December 30, 2019 |
| NCT03248388 | Completed | N/A | Argus II/ORCAM Device Study | August 31, 2017 | October 15, 2020 |
| NCT03281005 | Completed | Development of Visual Function Evaluation Method | November 1, 2017 | November 21, 2019 | |
| NCT03319524 | Completed | Clinical and Genetic Testing of Patients With Usher Syndrome | May 17, 2017 | June 1, 2018 | |
| NCT03322930 | Completed | Rod Sensitivity in Age-related Macular Degeneration (AMD) and Retinitis Pigmentosa (RP) | October 1, 2017 | March 1, 2019 | |
| NCT04238858 | Completed | N/A | Effects of Subtenon-injected Autologous Platelet-rich Plasma on Visual Functions in Eyes With Retinitis Pigmentosa | September 1, 2016 | January 30, 2018 |
| NCT03381235 | Completed | N/A | Exercise and RP (AVAMC and Emory) | February 23, 2018 | November 28, 2018 |
| NCT03406416 | Completed | N/A | Study of a Suprachoroidal Retinal Prosthesis | February 13, 2018 | December 18, 2020 |
| NCT04234438 | Completed | N/A | Management of Cystoid Macular Edema Secondary to Retinitis Pigmentosa Via Subliminal Micropulse Yellow Laser | January 1, 2018 | December 30, 2019 |
| NCT03444961 | Completed | N/A | Computer-Assisted Rehabilitation Environment Training After Argus Retinal Prosthesis | January 30, 2018 | June 20, 2018 |
| NCT03626207 | Completed | Development of Visual Function Evaluation Method (2) | October 4, 2018 | June 26, 2019 | |
| NCT02759952 | Enrolling by invitation | Clinical Characterization on PDE6A-related Retinitis Pigmentosa in Preparation to a Gene Therapy Trial | January 2013 | December 2025 | |
| NCT05786287 | Enrolling by invitation | Long-term Safety of UC-MSC Transplantation in Patients With Retinitis Pigmentosa | July 1, 2023 | July 13, 2025 | |
| NCT05921162 | Enrolling by invitation | A Long-Term Follow-Up Study in Subjects Who Received vMCO-I Administered Via Intravitreal Injection | July 14, 2023 | December 2024 | |
| NCT06162585 | Enrolling by invitation | Non-Interventional Long Term Follow-up Study of Participants Previously Enrolled in the RESTORE Study | December 8, 2023 | September 2027 | |
| NCT05158049 | Enrolling by invitation | Longitudinal Study of a Bionic Eye | December 9, 2021 | December 9, 2026 | |
| NCT06460844 | Not yet recruiting | Phase 1 | Study to Evaluate Safety of RTx-015 Injection in Retinitis Pigmentosa Patients | August 2024 | May 2026 |
| NCT02018692 | Not yet recruiting | Phase 1/Phase 2 | The Effect of Oral Administration of 9-cis Rich Powder of the Alga Dunaliella Bardawil on Visual Functions in Adolescent Patients With Retinitis Pigmentosa | March 1, 2025 | December 31, 2027 |
| NCT02465749 | Not yet recruiting | Early Phase 1 | Clinical Trials of Continuous Oxygen Therapy Combined With Blue Light Deprivation in the Treatment of Retinitis Pigmentosa | May 2015 | June 2025 |
| NCT05841862 | Not yet recruiting | N/A | Intravitreal Quantum Dots (QD) for Advanced Retinitis Pigmentosa (RP) (QUANTUM) | March 2024 | March 2025 |
| NCT05849987 | Not yet recruiting | In Depth Observational Clinical Trial Of Retinitis Pigmentosa Patients | May 2024 | May 2026 | |
| NCT05914233 | Not yet recruiting | N/A | Non-invasive Ultrasound Retinal Stimulation for Vision Restoration | June 15, 2024 | July 15, 2025 |
| NCT06076720 | Not yet recruiting | N/A | Evaluation of New Head-mounted Visual Aids Among Patients With Low Vision | October 10, 2023 | October 10, 2024 |
| NCT06224114 | Not yet recruiting | N/A | Coloured-light in Retinitis Pigmentosa. | March 2024 | October 2024 |
| NCT06292650 | Not yet recruiting | Early Phase 1 | Safety and Efficacy Study of Novel Gene Therapy ZM-02 for Retinitis Pigmentosa Patients | February 25, 2024 | December 25, 2028 |
| NCT06319872 | Not yet recruiting | Phase 1 | The Effects of Disulfiram (Antabuse®) on Visual Acuity in Patients With Retinal Degeneration | April 15, 2024 | April 15, 2025 |
| NCT06306690 | Recruiting | Biomarkers in Retinitis Pigmentosa | February 1, 2024 | April 2025 | |
| NCT03635645 | Recruiting | N/A | Experimental and Clinical Studies of Retinal Stimulation | October 30, 2017 | October 30, 2023 |
| NCT04558983 | Recruiting | A Natural History Study to Evaluate Functional and Anatomical Progression in Retinitis Pigmentosa | June 11, 2020 | January 2025 | |
| NCT04620876 | Recruiting | N/A | Bimodal and Coaxial High Resolution Ophtalmic Imaging | October 1, 2019 | October 15, 2024 |
| NCT02617966 | Recruiting | Rod and Cone Mediated Function in Retinal Disease | March 24, 2016 | December 30, 2029 | |
| NCT04805658 | Recruiting | Natural History Study of Retinitis Pigmentosa Type 11 | February 1, 2021 | February 1, 2025 | |
| NCT02435940 | Recruiting | Inherited Retinal Degenerative Disease Registry | June 2014 | June 2037 | |
| NCT02014389 | Recruiting | Evaluation of Objective Perimetry Using Chromatic Multifocal Pupillometer | December 1, 2013 | December 31, 2026 | |
| NCT05147701 | Recruiting | Phase 1 | Safety of Cultured Allogeneic Adult Umbilical Cord Derived Mesenchymal Stem Cells for Eye Diseases | February 1, 2022 | January 2026 |
| NCT01866371 | Recruiting | High Resolution Retinal Imaging | May 2013 | December 2027 | |
| NCT05203939 | Recruiting | Phase 1/Phase 2 | Study to Assess the Safety and Efficacy of OCU400 for Retinitis Pigmentosa and Leber Congenital Amaurosis | January 24, 2022 | December 2024 |
| NCT05258032 | Recruiting | Structural and Functional Characterization of Rare Ocular Diseases | November 24, 2021 | November 24, 2025 | |
| NCT05282953 | Recruiting | Phase 1/Phase 2 | A Phase I/II Dose-escalating Study of the Safety, Tolerability and Efficacy of KIO-301 Administered Intravitreally to Patients With Retinitis Pigmentosa and Choroideremia (ABACUS) | November 10, 2022 | January 2025 |
| NCT01793168 | Recruiting | Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford | July 2010 | December 2100 | |
| NCT05355415 | Recruiting | Adaptive Optics Imaging of Outer Retinal Diseases | August 27, 2021 | April 25, 2024 | |
| NCT05413148 | Recruiting | Phase 2/Phase 3 | The Effect of Stem Cells and Stem Cell Exosomes on Visual Functions in Patients With Retinitis Pigmentosa | August 5, 2022 | December 15, 2023 |
| NCT05537220 | Recruiting | Phase 3 | Oral N-acetylcysteine for Retinitis Pigmentosa | October 11, 2023 | December 2028 |
| NCT05573984 | Recruiting | Natural History of PRPF31 Mutation-Associated Retinal Dystrophy | July 7, 2022 | April 30, 2027 | |
| NCT05589714 | Recruiting | Universal Rare Gene Study: A Registry and Natural History Study of Retinal Dystrophies Associated With Rare Disease-Causing Genetic Variants | May 11, 2023 | December 15, 2026 | |
| NCT05748873 | Recruiting | Phase 1/Phase 2 | Promising ROd-cone DYstrophy Gene therapY | April 12, 2023 | March 2029 |
| NCT01432847 | Recruiting | Cell Collection to Study Eye Diseases | September 7, 2011 | ||
| NCT05793515 | Recruiting | Mechanisms of Inherited Retinal Dystrophies Using Whole Genome Sequencing and in Vitro and in Vivo Models | November 15, 2022 | November 15, 2025 | |
| NCT05805007 | Recruiting | Early Phase 1 | Safety and Tolerability Study of Gene Editing Drug ZVS203e in Participants With Retinitis Pigmentosa | September 12, 2023 | April 2026 |
| NCT05809635 | Recruiting | Study of BEST1 Vitelliform Macular Dystrophy | March 30, 2021 | May 31, 2025 | |
| NCT05853107 | Recruiting | N/A | Pilot Study of AuTNA I | May 12, 2023 | February 28, 2026 |
| NCT05909488 | Recruiting | Phase 2/Phase 3 | Role of UC-MSC and CM to Inhibit Vision Loss in Retinitis Pigmentosa Phase I/II | September 1, 2023 | December 1, 2025 |
| NCT06323772 | Recruiting | Natural History Study in Patients With PDE6A-, PDE6B- and RHO-linked Retinitis Pigmentosa | November 17, 2023 | March 2027 | |
| NCT00254605 | Recruiting | Retinal Imaging in Patients With Inherited Retinal Degenerations | November 2005 | November 2028 | |
| NCT06375239 | Recruiting | Observational Study to Assess Endpoint Operational Feasibility & Measurement Properties in Retinitis Pigmentosa Patients | April 5, 2024 | April 30, 2026 | |
| NCT06242379 | Recruiting | Phase 1/Phase 2 | Safety and Efficacy of Stem Cell Small Extracellular Vesicles in Patients With Retinitis Pigmentosa | May 23, 2024 | February 2026 |
| NCT06291935 | Recruiting | Phase 1 | Safety and Tolerability of Intravitreal Administration of VG901 in Patients With Retinitis Pigmentosa Due to Mutations in the CNGA1 Gene | September 1, 2023 | December 2025 |
| NCT06388200 | Recruiting | Phase 3 | A Phase 3 Study Of OCU400 Gene Therapy for the Treatment Of Retinitis Pigmentosa | April 26, 2024 | October 30, 2026 |
| NCT03990727 | Recruiting | Phenotype Correlates Genotype of Inherited Retina Dystrophies, Retinitis Pigmentosa, Con>Rod Dystrophies. | August 2009 | September 30, 2025 | |
| NCT03845218 | Recruiting | Retinitis Pigmentosa Clinical Measures and Repeatability Testing of Potential Outcome Measures | September 27, 2019 | October 30, 2024 | |
| NCT04120883 | Recruiting | Phase 1/Phase 2 | Oral Hydroxychloroquine (HCQ) for Retinitis Pigmentosa Caused by P23H- Rhodopsin (RHO) | February 25, 2020 | January 2026 |
| NCT03328130 | Recruiting | Phase 1/Phase 2 | Safety and Efficacy Study in Patients With Retinitis Pigmentosa Due to Mutations in PDE6B Gene | November 6, 2017 | December 2029 |
| NCT04278131 | Recruiting | Phase 1/Phase 2 | BS01 in Patients With Retinitis Pigmentosa | February 6, 2020 | December 30, 2029 |
| NCT04284293 | Recruiting | Phase 1 | CNS10-NPC for the Treatment of RP | July 22, 2021 | November 2025 |
| NCT03011541 | Recruiting | N/A | Stem Cell Ophthalmology Treatment Study II | January 2016 | July 31, 2026 |
| NCT02860520 | Recruiting | Clinical Implication of Retinitis Pigmentosa Molecular Diagnostic Using High Throughput Sequencing. | November 3, 2015 | August 2025 | |
| NCT04359108 | Recruiting | N/A | Environmental Localization Mapping and Guidance for Visual Prosthesis Users | March 16, 2021 | July 30, 2024 |
| NCT04295304 | Terminated | N/A | NR600 System Retinal Prosthesis for Patients With Retinal Degenerative Diseases | January 17, 2020 | March 12, 2023 |
| NCT01786395 | Terminated | Phase 3 | Phase III Efficacy and Safety Clinical Study of UF-021 for Treatment of Retinitis Pigmentosa | March 2013 | |
| NCT02926092 | Terminated | Observational Natural History Study of Autosomal Dominant Retinitis Pigmentosa (adRP) | March 13, 2017 | April 13, 2017 | |
| NCT01490827 | Terminated | Argus® II Retinal Prosthesis System Post-Market Surveillance Study | November 2011 | March 31, 2020 | |
| NCT01505062 | Terminated | Phase 1/Phase 2 | Study of SAR421869 in Participants With Retinitis Pigmentosa Associated With Usher Syndrome Type 1B | March 26, 2012 | August 16, 2019 |
| NCT00458575 | Terminated | Phase 1 | A Study to Evaluate the Safety of CNTO 2476 in Patients With Advanced Retinitis Pigmentosa | April 2007 | August 2013 |
| NCT05085964 | Terminated | Phase 2 | An Open-Label Extension Study to Evaluate Safety & Tolerability of QR-421a in Subjects With Retinitis Pigmentosa | September 16, 2021 | October 18, 2022 |
| NCT00004345 | Terminated | Study of Dietary N-3 Fatty Acids in Patients With Retinitis Pigmentosa and Usher Syndrome | October 1999 | ||
| NCT01860092 | Terminated | New Enrollment Post-Approval Study of the Argus® II Retinal Prosthesis System | January 2014 | March 2020 | |
| NCT05176717 | Terminated | Phase 2/Phase 3 | Study to Evaluate the Efficacy Safety and Tolerability of QR-421a in Subjects With RP Due to Mutations in Exon 13 of the USH2A Gene With Early to Moderate Vision Loss (Celeste) | December 15, 2021 | August 2, 2022 |
| NCT01415453 | Terminated | N/A | Evoked Retinal Response | July 2011 | June 2012 |
| NCT04820244 | Unknown status | Characterizing Rate of Progression in USHer Syndrome (CRUSH) Study | February 11, 2019 | March 2, 2024 | |
| NCT04864496 | Unknown status | Phase 2 | Effects of Treatment With N- Acetylcysteine on Visual Outcomes in Patients With Retinitis Pigmentosa | April 17, 2021 | December 20, 2022 |
| NCT02709876 | Unknown status | Phase 1/Phase 2 | Autologous Bone Marrow-Derived CD34+, CD133+, and CD271+ Stem Cell Transplantation for Retinitis Pigmentosa | April 2014 | March 2021 |
| NCT03078309 | Unknown status | Early Phase 1 | The Effects of Cannabis on Visual Functions in Healthy and Retinitis Pigmentosa Patients | September 1, 2018 | December 2021 |
| NCT03944239 | Unknown status | Phase 1 | Safety and Efficacy of Subretinal Transplantation of Clinical Human Embryonic Stem Cell Derived Retinal Pigment Epitheliums in Treatment of Retinitis Pigmentosa | May 2020 | December 2021 |
| NCT04281732 | Unknown status | Visual Performance Measures in a Virtual Reality Environment for Assessing Clinical Trial Outcomes in Those With Severely Reduced Vision | October 1, 2018 | December 31, 2020 | |
| NCT00433277 | Unknown status | N/A | Autoimmunity in Retinitis Pigmentosa | ||
| NCT03772938 | Unknown status | Phase 1 | Stem Cells Therapy in Degenerative Diseases of the Retina | December 13, 2018 | March 31, 2020 |
| NCT02837640 | Unknown status | Phase 2 | Studying a Potential Protective Effect of L-Dopa on Retinitis Pigmentosa | June 2016 | June 2021 |
| NCT00427180 | Unknown status | N/A | IRIS PILOT - Extended Pilot Study With a Retinal Implant System | December 2006 | December 2010 |
| NCT04448860 | Unknown status | N/A | Validation of Standardized Test Protocols to Assess the Impact of Visual Pathologies in Daily Life Activities | October 4, 2019 | October 4, 2023 |
| NCT02804360 | Unknown status | Phase 2 | Intravitreal Dexamethasone Implant in Retinitis Pigmentosa-related Macular Edema- a Retrospective Study | January 2015 | December 2016 |
| NCT04129021 | Unknown status | N/A | Multimodal Ophthalmic Imaging | July 15, 2019 | June 30, 2023 |
| NCT03998384 | Unknown status | N/A | A New Treatment of Retinitis Pigmentosa | January 1, 2020 | December 31, 2022 |
| NCT01999049 | Unknown status | Observational Study of the Argus® II Retinal Prosthesis System | April 2014 | January 2017 | |
| NCT01914913 | Unknown status | Phase 1/Phase 2 | Clinical Study to Evaluate Safety and Efficacy of BMMNC in Retinitis Pigmentosa | September 2014 | November 2016 |
| NCT04128150 | Unknown status | High Resolution Retina Imaging | January 17, 2018 | January 30, 2024 | |
| NCT02309866 | Unknown status | Identifying Genes and Mutations Underlying Retinitis Pigmentosa and Allied Diseases | January 2015 | January 2018 | |
| NCT02548572 | Withdrawn | N/A | Transcorneal Electrical Stimulation for the Treatment of Retinitis Pigmentosa - a Safety and Efficacy Multicenter Study | January 2019 | December 2020 |
| NCT03418116 | Withdrawn | N/A | Argus II Retinal Prosthesis System - Better Vision RP Study | November 1, 2018 | November 2021 |
| NCT02588430 | Withdrawn | PMCF Study for Partial Vision Restoration Using the Subretinal Implant RETINA IMPLANT Alpha AMS | March 2019 | June 2030 | |
| NCT03629899 | Withdrawn | N/A | RETINA IMPLANT Alpha AMS in Blind Patients With Retinitis Pigmentosa | March 2019 | July 2025 |
- Disase is a (Disease Ontology)
- DOID:8466
- Cross Reference ID (Disease Ontology)
- GARD:5694
- Cross Reference ID (Disease Ontology)
- ICD10CM:H35.52
- Cross Reference ID (Disease Ontology)
- MESH:C538365
- Cross Reference ID (Disease Ontology)
- MESH:D012174
- Cross Reference ID (Disease Ontology)
- MIM:PS268000
- Cross Reference ID (Disease Ontology)
- NCI:C85045
- Cross Reference ID (Disease Ontology)
- ORDO:791
- Cross Reference ID (Disease Ontology)
- SNOMEDCT_US_2023_03_01:155113002
- Cross Reference ID (Disease Ontology)
- UMLS_CUI:C0035334
- Cross Reference ID (Disease Ontology)
- UMLS_CUI:C0220701
- Exact Synonym (Disease Ontology)
- pericentral pigmentary retinopathy
- OMIM Phenotype Series Number (OMIM)
- PS268000
- OrphaNumber from OrphaNet (Orphanet)
- 791
- MedGen concept unique identifier (MedGen Concept name)
- C0035334
- MedGen unique identifier (MedGen Concept name)
- 20551
- MeSH unique ID (MeSH (Medical Subject Headings))
- D012174