chr9:21967751:> Detail (hg19) (CDKN2A)

Information

Genome

Assembly Position
hg19 chr9:21,967,751-21,995,300
hg38 chr9:21,967,752-21,995,301 

HGVS

Type Transcript Protein
Summary

MGeND

Clinical significance
Variant entry
GWAS entry
Disease area statistics Show details

Frequency

[No Data.]

Prediction

[No Data.]

ClinVar

Clinical Significance
Review star [No Data.]
Show details
Links
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
[No Data.]
CIViC
Disease Drug EL ET ED CS VO TR Pubmed Links
pancreatic cancer Palbociclib B Predictive Does Not Support Sensitivity/Response Somatic 4 Detail
cholangiocarcinoma Palbociclib B Predictive Does Not Support Sensitivity/Response Somatic 4 Detail
DisGeNET
Score Disease name Description Source Pubmed Links
0.144 squamous cell carcinoma The p14 promoter was unmethylated in 86.7 % of OSCC and in 85.7 % of LSCC patien... BeFree,GAD,LHGDN 24710824 Detail
0.144 squamous cell carcinoma The correlation between p16 expression and INK4a locus mutation with grades and ... BeFree,GAD,LHGDN 24739827 Detail
0.144 squamous cell carcinoma HPV infection appears to be involved in cancer progression in SQC by promoting t... BeFree,GAD,LHGDN 25544708 Detail
0.144 squamous cell carcinoma p16INK4A expression in squamous cell carcinomas of the vagina and the vulva in T... BeFree,GAD,LHGDN 25605180 Detail
0.144 squamous cell carcinoma Development of squamous cell cancer of head and neck (SCCHN) is associated with ... BeFree,GAD,LHGDN 25640361 Detail
0.144 squamous cell carcinoma Human papillomavirus (HPV), p16 expression, and TP53 mutations are known prognos... BeFree,GAD,LHGDN 25871546 Detail
0.144 squamous cell carcinoma These findings utilize morphologic and immunohistochemical analysis to support H... BeFree,GAD,LHGDN 26171917 Detail
0.008 Carcinoma, Transitional Cell To determine the potential association between HPV infection and the squamous ce... BeFree,LHGDN 24675970 Detail
<0.001 carcinosarcoma NA BeFree Detail
<0.001 Cardiomyopathy, Dilated Transcriptome analysis of mouse and human DCM samples indicates that p16(INK4a) ... BeFree 25751743 Detail
<0.001 Cardiovascular Diseases NA BeFree Detail
<0.001 celiac disease A dense infiltrate of IL-6(+) mononuclear cells was detected in active coeliac d... BeFree 25198673 Detail
0.007 intracranial aneurysm NA BeFree,GAD Detail
0.005 brain ischemia NA GAD Detail
0.014 Malignant tumor of cervix Medline, Embase and China National Knowledge Infrastructures were searched to id... BeFree 25461355 Detail
0.014 Malignant tumor of cervix Methylation of the p16(INK4a) gene occurs early in the development of cervical c... BeFree 25579180 Detail
0.014 Malignant tumor of cervix p16INK4A expression could be used as a useful marker for HPV positivity in vagin... BeFree 25605180 Detail
0.014 Malignant tumor of cervix Moreover, p16 protein was associated with CIN grade and lymph node metastases in... BeFree 25910412 Detail
<0.001 cervical polyp NA BeFree Detail
<0.001 Uterine Cervicitis Immunohistochemistry of p16INK4A staining shows nil (0/25) expression in the cer... BeFree 25361681 Detail
<0.001 Cervix Diseases NA BeFree Detail
0.002 Cervical dysplasia NA BeFree Detail
0.003 Uterine Cervical Neoplasm NA BeFree,LHGDN Detail
<0.001 bile duct adenoma In contrast, the expression of p16INK4a was seen in most bile duct adenomas and ... BeFree 25289642 Detail
<0.001 cholangitis NA BeFree Detail
<0.001 Primary biliary cirrhosis NA BeFree Detail
0.005 Cholangitis, Sclerosing NA BeFree,GAD,LHGDN Detail
0.005 chondrosarcoma We show that p16/CDKN2A copy number variation occurs subsequent to the IDH1 muta... BeFree,LHGDN 25432631 Detail
<0.001 chordoma Genotyping cancer-associated genes in chordoma identifies mutations in oncogenes... BeFree 24983247 Detail
0.002 Congenital chromosomal disease NA BeFree Detail
0.008 ulcerative colitis Progression from ulcerative colitis (UC) toward colorectal carcinoma (CRC) is mu... BeFree,LHGDN 25076849 Detail
0.084 Colonic Neoplasms NA BeFree,LHGDN,RGD Detail
0.024 colorectal carcinoma Investigation of IL-23 (p19, p40) and IL-23R identifies nuclear expression of IL... BeFree 25015728 Detail
0.024 colorectal carcinoma Progression from ulcerative colitis (UC) toward colorectal carcinoma (CRC) is mu... BeFree 25076849 Detail
0.024 colorectal carcinoma Combined methylation of p16 and hMLH1 (CMETH2) discriminates a subpopulation wit... BeFree 25576161 Detail
0.024 colorectal carcinoma An adenoviral construct of the human p14ARF gene (a tumor suppressor) and a 22 a... BeFree 25935465 Detail
0.046 Colorectal Neoplasms NA BeFree,GAD,LHGDN Detail
<0.001 Condylomata Acuminata NA BeFree Detail
<0.001 Crohn Disease NA BeFree Detail
0.007 adenoid cystic carcinoma NA BeFree,LHGDN Detail
<0.001 cystadenoma NA BeFree Detail
<0.001 cystitis NA BeFree Detail
<0.001 Phyllodes Tumor NA BeFree Detail
<0.001 Mental Depression NA BeFree Detail
<0.001 depressive disorder NA BeFree Detail
0.001 Diabetes We review the current knowledge, from studies using human and mouse models, desc... BeFree 25744911 Detail
0.011 diabetes mellitus We review the current knowledge, from studies using human and mouse models, desc... BeFree,GAD 25744911 Detail
0.003 Diabetes Mellitus, Insulin-Dependent NA BeFree,GAD Detail
<0.001 Diabetic Nephropathy NA BeFree Detail
<0.001 Dwarfism NA BeFree Detail
0.007 dysplastic nevus syndrome NA BeFree,GAD,LHGDN Detail
0.002 Eczema NA GAD Detail
<0.001 Experimental Autoimmune Encephalomyelitis NA BeFree Detail
0.088 Endometrial Neoplasms NA LHGDN,RGD Detail
<0.001 endometrial hyperplasia NA BeFree Detail
0.038 Malignant neoplasm of lung Therefore, we hypothesized that the genetic variants in these three genes influe... BeFree 16912209 Detail
0.030 Carcinoma of lung Therefore, we hypothesized that the genetic variants in these three genes influe... BeFree 16912209 Detail
0.004 endometriosis NA BeFree,LHGDN Detail
0.002 Ependymoma NA BeFree Detail
<0.001 erythema nodosum NA BeFree Detail
0.222 Esophageal Neoplasms Thus, p16 hypermethylation may aid as a biomarker in identifying habitués at gre... BeFree,CTD_human,GAD,LHGDN,RGD 25361631 Detail
<0.001 peptic esophagitis NA BeFree Detail
<0.001 Exanthema Polysomy 6 and p16 deletion were significantly more frequent in noninvasive than... BeFree 25517961 Detail
<0.001 Eyelid Neoplasms Furthermore, p16 overexpression in eyelid SCs was also significantly higher than... BeFree 25468813 Detail
<0.001 Fatty Liver NA BeFree Detail
0.002 Fetal Diseases NA GAD Detail
<0.001 fibrosarcoma NA BeFree Detail
<0.001 pathologic fistula NA BeFree Detail
<0.001 Fuchs Endothelial Dystrophy NA BeFree Detail
<0.001 Gall Bladder Diseases NA BeFree Detail
0.003 gallbladder neoplasm NA BeFree,LHGDN Detail
<0.001 gastrinoma Deletions of RDINK4/ARF enhancer in gastrinomas and nonfunctioning pancreatic ne... BeFree 25003221 Detail
<0.001 gastritis NA BeFree Detail
<0.001 Gastritis, Atrophic NA BeFree Detail
0.120 glaucoma NA BeFree,CTD_human Detail
0.023 glioblastoma Finally, the G-CIMP+ Ink4a-Arf-/- EGFRvIII glioblastoma line was more resistant ... BeFree,GAD,LHGDN 25277177 Detail
0.023 glioblastoma CD47 activation-induced UHRF1 over-expression is associated with silencing of tu... BeFree,GAD,LHGDN 25550546 Detail
0.173 Glioma Bmi-1 regulates the migration and invasion of glioma cells through p16. BeFree,CTD_human,GAD,LHGDN 25262972 Detail
0.173 Glioma BRAF mutation and CDKN2A deletion define a clinically distinct subgroup of child... BeFree,CTD_human,GAD,LHGDN 25667294 Detail
0.173 Glioma These findings suggest that CDKN2A testing may provide further clinical aid in l... BeFree,CTD_human,GAD,LHGDN 25853694 Detail
0.173 Glioma CDKN2A (p16) mRNA decreased expression is a marker of poor prognosis in malignan... BeFree,CTD_human,GAD,LHGDN 25921285 Detail
0.173 Glioma These findings show that CDKN2 p16 540 C>G, CDKN2 p16 580 C>T and MDM2 SNP309 T>... BeFree,CTD_human,GAD,LHGDN 26124340 Detail
<0.001 Glycogen Storage Disease Type VI NA BeFree Detail
<0.001 granulosa cell tumor NA BeFree Detail
<0.001 Graves Disease NA BeFree Detail
<0.001 Hamartoma NA BeFree Detail
0.002 Hay fever NA GAD Detail
0.005 Head and Neck Neoplasms NA GAD Detail
<0.001 cardiac arrest ECCCs had SCA-like features with rare expression of estrogen receptor/progestero... BeFree 25473756 Detail
0.005 Heart Diseases NA GAD Detail
<0.001 hemangiopericytoma NA BeFree Detail
0.001 Hemangiosarcoma NA BeFree Detail
0.002 Hemorrhage NA GAD Detail
<0.001 hepatitis NA BeFree Detail
<0.001 hepatitis A NA BeFree Detail
0.012 hepatitis B NA BeFree,LHGDN Detail
<0.001 Hepatitis, Chronic NA BeFree Detail
0.002 hepatitis C NA BeFree Detail
<0.001 Herpes NOS NA BeFree Detail
<0.001 Herpes Simplex Infections NA BeFree Detail
<0.001 Histiocytosis, Langerhans-Cell Interestingly, all the aggressive cases did not express p16(INK4a), thus suggest... BeFree 24471909 Detail
0.005 HIV Infections Peptides (9mer to 11mer) were designed based on HLA-I-binding algorithms for B*2... BeFree,GAD 26322665 Detail
0.007 Hodgkin Disease NA BeFree,LHGDN Detail
<0.001 Huntington disease NA BeFree Detail
0.005 Hypercholesterolemia, Familial NA GAD Detail
0.002 hyperglycemia NA GAD Detail
0.080 Hyperplasia NA RGD Detail
0.002 Hypersensitivity NA GAD Detail
0.085 Hypertensive disease NA BeFree,GAD,RGD Detail
<0.001 pulmonary hypertension NA BeFree Detail
0.002 Insulin resistance NA GAD Detail
<0.001 insulinoma NA BeFree Detail
0.003 keratoacanthoma NA BeFree,LHGDN Detail
<0.001 keratosis NA BeFree Detail
0.010 actinic keratosis NA BeFree,LHGDN Detail
<0.001 seborrheic keratosis NA BeFree Detail
<0.001 Kidney Diseases NA BeFree Detail
0.011 Kidney Failure, Acute NA BeFree Detail
0.081 Kidney Neoplasm NA BeFree,RGD Detail
0.121 Vulvar Lichen Sclerosus NA BeFree,CTD_human Detail
0.002 Laryngeal neoplasm NA GAD Detail
0.006 Fibroid Tumor NA BeFree,LHGDN Detail
0.004 leiomyosarcoma NA BeFree,LHGDN Detail
<0.001 tuberculoid leprosy NA BeFree Detail
0.022 leukemia NA BeFree,GAD,LHGDN Detail
0.004 chronic lymphocytic leukemia NA BeFree Detail
<0.001 hairy cell leukemia NA BeFree Detail
0.005 lymphoid leukemia NA BeFree,LHGDN Detail
0.020 Acute lymphocytic leukemia Deletions of EBF1, IKZF1, and CDKN2A/B have an independent adverse prognosis for... BeFree 26194343 Detail
0.008 Leukemia, Lymphocytic, Acute, L1 NA BeFree Detail
<0.001 acute monocytic leukemia NA BeFree Detail
0.017 Leukemia, Myelocytic, Acute NA BeFree,GAD,LHGDN Detail
0.001 myeloid leukemia NA BeFree Detail
0.009 Myeloid Leukemia, Chronic NA BeFree,LHGDN Detail
<0.001 Leukemia, Myeloid, Chronic-Phase NA BeFree Detail
0.001 Leukemia, Plasma Cell NA BeFree Detail
0.001 Precursor B-Cell Lymphoblastic Leukemia-Lymphoma NA BeFree Detail
<0.001 acute promyelocytic leukemia NA BeFree Detail
0.003 Leukemia, T-Cell NA BeFree Detail
0.009 Adult T-Cell Lymphoma/Leukemia NA BeFree,GAD Detail
0.003 Leukoplakia NA BeFree,LHGDN Detail
0.003 Leukoplakia, Oral NA BeFree,GAD Detail
0.001 Lichen Sclerosus et Atrophicus NA BeFree Detail
0.004 liposarcoma NA BeFree,LHGDN Detail
0.005 liver cirrhosis NA BeFree,GAD Detail
0.001 Liver diseases NA BeFree Detail
<0.001 Alcoholic Liver Diseases NA BeFree Detail
0.123 Liver neoplasms NA BeFree,CTD_human Detail
<0.001 Lung diseases NA BeFree Detail
0.003 Chronic Obstructive Airway Disease NA BeFree,GAD Detail
0.245 Lung Neoplasms NA BeFree,CTD_human,LHGDN,RGD Detail
<0.001 Lupus Erythematosus, Systemic NA BeFree Detail
<0.001 Lymphatic Metastasis NA BeFree Detail
0.147 lymphoma NA BeFree,CTD_human,GAD,LHGDN Detail
0.005 Lymphoma, Follicular NA BeFree,LHGDN Detail
<0.001 reticulosarcoma NA BeFree Detail
0.002 Lymphoma, Non-Hodgkin NA GAD Detail
<0.001 Waldenstrom Macroglobulinemia NA BeFree Detail
0.019 Malignant neoplasm of stomach Cell-cycle regulation was affected by aberrant methylation of CDKN2A and CHFR in... BeFree,GAD 24510342 Detail
0.019 Malignant neoplasm of stomach The present results indicated that the methylation of p16, CDH1, MGMT, and hMLH1... BeFree,GAD 24816738 Detail
0.019 Malignant neoplasm of stomach The relationship between P16 gene promoter methylation and gastric cancer: a met... BeFree,GAD 25693938 Detail
0.019 Malignant neoplasm of stomach ANRIL, a lncRNA co-clustered mainly with p14/ARF has been reported to be dysregu... BeFree,GAD 25966845 Detail
0.019 Malignant neoplasm of stomach Moreover, their combined treatment synergistically arrested GC cells at G0/G1 ph... BeFree,GAD 26173505 Detail
0.002 Animal Mammary Neoplasms NA GAD Detail
0.080 Mammary Neoplasms, Experimental NA RGD Detail
0.005 medulloblastoma NA BeFree,LHGDN Detail
0.002 multiple endocrine neoplasia type 1 NA GAD Detail
0.014 meningioma Progression to a clinically aggressive meningioma is linked to inactivation of C... BeFree,GAD,LHGDN 25993161 Detail
0.220 Mesothelioma NA BeFree,CTD_human,LHGDN,RGD Detail
<0.001 Metabolic Diseases Functional genomics of the CDKN2A/B locus in cardiovascular and metabolic diseas... BeFree 25744911 Detail
0.003 Metaplasia NA LHGDN Detail
<0.001 Microphthalmos NA BeFree Detail
0.007 Mixed Salivary Gland Tumor NA BeFree,LHGDN Detail
0.001 Monoclonal Gammopathy of Undetermined Significance NA BeFree Detail
0.002 Monosomy NA BeFree Detail
0.013 Mouth Neoplasms NA BeFree,GAD,LHGDN Detail
0.134 multiple myeloma The cyclin-dependent kinase inhibitor 1 (CDKN2B or p15(INK4B) ) gene lies adjace... BeFree,CTD_human,LHGDN 25382971 Detail
<0.001 multiple sclerosis NA BeFree Detail
<0.001 myasthenia gravis As p16 (CDKN2A), a marker of HPV infections, was up-regulated in MG-T, we thus s... BeFree 24440286 Detail
0.007 mycosis fungoides NA BeFree,LHGDN Detail
<0.001 Myeloproliferative disease Dysregulation of the MIRLET7/HMGA2 axis with methylation of the CDKN2A promoter ... BeFree 25236537 Detail
0.002 Nasopharyngeal Neoplasms NA GAD Detail
0.001 Neck Neoplasms NA BeFree Detail
0.120 Neoplasm Invasiveness NA CTD_human Detail
0.034 Neoplasm Metastasis Alcohol consumption, location, and features of neck metastasis were correlated w... BeFree,LHGDN 24993345 Detail
0.002 Neoplasm Recurrence, Local NA GAD Detail
0.003 multiple endocrine neoplasia NA LHGDN Detail
0.007 Neoplasms, Multiple Primary NA GAD Detail
0.003 nephritis NA LHGDN Detail
<0.001 nephroblastoma NA BeFree Detail
0.001 Nervous System Neoplasms NA BeFree Detail
0.003 neurilemmoma NA BeFree,LHGDN Detail
0.129 neuroblastoma NA BeFree,CTD_human,LHGDN Detail
0.002 neurofibroma NA BeFree Detail
0.004 neurofibromatosis 1 NA BeFree,GAD Detail
<0.001 Neurofibromatosis 2 NA BeFree Detail
0.002 acoustic neuroma NA GAD Detail
0.007 Nevus NA BeFree,GAD Detail
0.007 Melanocytic nevus NA BeFree,LHGDN Detail
0.085 obesity NA BeFree,GAD,RGD Detail
0.002 Occupational Diseases NA GAD Detail
0.006 oligodendroglioma After adjustment for IDH mutation, sex, and age, CDKN2A deletion was strongly as... BeFree,GAD 25853694 Detail
<0.001 Oropharyngeal Neoplasms NA BeFree Detail
0.081 Degenerative polyarthritis NA BeFree,RGD Detail
0.014 osteosarcoma Further, we could deduce genes with possible prognostic significance in OS for f... BeFree,LHGDN 25848766 Detail
0.011 ovarian carcinoma NA BeFree Detail
0.004 Pancreatic Diseases NA BeFree,LHGDN Detail
0.153 Pancreatic Neoplasm NA BeFree,CTD_human,GAD,LHGDN Detail
<0.001 pancreatitis NA BeFree Detail
0.005 papilloma None of the cell lines showed strong immunopositivity of p16 or presence of huma... BeFree 24816148 Detail
0.005 papilloma Immunohistochemical staining provided diagnostic results for all of the examined... BeFree 24914388 Detail
0.005 papilloma Human papilloma virus early proteins E6 (HPV16/18-E6) and the cell cycle marker ... BeFree 24925218 Detail
0.005 papilloma Another significant finding was a very poor concordance between p16 expression a... BeFree 25339028 Detail
0.005 papilloma Positivity for HPV DNA (44 samples, 18.9 %) and p16(INK4A) expression (102 sampl... BeFree 25575976 Detail
0.005 papilloma Formalin-fixed, paraffin-embedded material from each case was evaluated for p16 ... BeFree 25724573 Detail
0.004 paraganglioma FGFR1, -2, and -4, VEGFR2, PDGFRα, and p16 were overexpressed in primary human p... BeFree,LHGDN 24390213 Detail
<0.001 Extra-Adrenal Paraganglioma NA BeFree Detail
0.003 Parkinson disease NA LHGDN Detail
<0.001 Penile Neoplasms NA BeFree Detail
0.005 periodontitis NA GAD,LHGDN Detail
<0.001 Periodontitis, Juvenile NA BeFree Detail
0.120 Peripheral neuropathy NA CTD_human Detail
<0.001 Peutz-Jeghers syndrome NA BeFree Detail
0.002 Pharyngeal Neoplasms NA GAD Detail
0.002 pheochromocytoma FGFR1, -2, and -4, VEGFR2, PDGFRα, and p16 were overexpressed in primary human p... BeFree 24390213 Detail
0.004 pituitary adenoma NA BeFree Detail
0.004 Pituitary Diseases NA BeFree Detail
0.011 Pituitary Neoplasms NA BeFree,LHGDN Detail
<0.001 plasmacytoma NA BeFree Detail
0.004 Pleural effusion disorder NA BeFree,LHGDN Detail
<0.001 polycythemia vera NA BeFree Detail
0.003 Adenomatous Polyposis Coli In the present study, the diagnostic utility of the SHOX2 assay was tested with ... BeFree 25331797 Detail
0.003 Adenomatous Polyposis Coli The aim of this study was to investigate promoter methylation of certain tumor s... BeFree 25417611 Detail
<0.001 polyps NA BeFree Detail
0.013 Precancerous Conditions NA BeFree,GAD Detail
<0.001 Preleukemia NA BeFree Detail
0.009 Prostatic Neoplasms NA BeFree,GAD,LHGDN Detail
<0.001 SKIN/HAIR/EYE PIGMENTATION, VARIATION IN, 2 (disorder) Sequence analysis demonstrated a known deleterious mutation in CDKN2A (G-34T) an... BeFree 18025365 Detail
<0.001 Protein Deficiency The prime aim of this study was to evaluate the mismatch-repair (MMR)-protein de... BeFree 25457183 Detail
0.002 psoriasis NA BeFree Detail
<0.001 pterygium NA BeFree Detail
<0.001 pulmonary emphysema NA BeFree Detail
<0.001 Rectal polyp NA BeFree Detail
0.029 retinoblastoma The aim was to explore putative differences in p16(INK) (4a) -retinoblastoma (Rb... BeFree,LHGDN 25123601 Detail
0.088 rhabdomyosarcoma NA BeFree,LHGDN,RGD Detail
0.001 schistosomiasis NA BeFree Detail
0.002 schizophrenia NA GAD Detail
<0.001 Sebaceous Gland Neoplasms The prime aim of this study was to evaluate the mismatch-repair (MMR)-protein de... BeFree 25457183 Detail
<0.001 seminoma NA BeFree Detail
0.123 Sezary syndrome NA CTD_human,LHGDN Detail
<0.001 silicosis NA BeFree Detail
<0.001 Dermatologic disorders NA BeFree Detail
0.042 Skin Neoplasms NA BeFree,GAD Detail
<0.001 Soft Tissue Neoplasms NA BeFree Detail
0.002 Starvation NA GAD Detail
0.210 Stomach Neoplasms NA BeFree,CTD_human,GAD,LHGDN,RGD Detail
0.008 Cerebrovascular accident NA BeFree,GAD Detail
0.002 Sunburn NA GAD Detail
<0.001 Supratentorial Neoplasms NA BeFree Detail
0.001 synovial sarcoma NA BeFree Detail
0.003 teratoma NA LHGDN Detail
<0.001 Testicular Neoplasms NA BeFree Detail
0.121 thymoma As p16 (CDKN2A), a marker of HPV infections, was up-regulated in MG-T, we thus s... BeFree,CTD_human 24440286 Detail
0.007 Thyroid Neoplasm NA BeFree,LHGDN Detail
0.080 Tongue Neoplasms NA RGD Detail
0.120 Chromosomal translocation NA CTD_human Detail
0.002 Chagas disease NA GAD Detail
<0.001 tuberous sclerosis NA BeFree Detail
<0.001 Unipolar Depression NA BeFree Detail
0.120 Genitourinary Neoplasms NA CTD_human Detail
<0.001 Urologic Diseases NA BeFree Detail
<0.001 Uterine Fibroids NA BeFree Detail
0.002 Uveal Neoplasms NA GAD Detail
<0.001 Malignant Vaginal Neoplasm NA BeFree Detail
0.003 Vascular Diseases NA BeFree,GAD Detail
0.001 Virus Diseases NA BeFree Detail
<0.001 xeroderma pigmentosum NA BeFree Detail
<0.001 Hallopeau-Siemens Disease NA BeFree Detail
<0.001 Ichthyosis, X-Linked NA BeFree Detail
0.012 B-Cell Lymphomas NA BeFree,LHGDN Detail
<0.001 High Grade Lymphoma (neoplasm) NA BeFree Detail
0.125 diffuse large B-cell lymphoma NA BeFree,CTD_human Detail
<0.001 Immunoblastic Large-Cell Lymphoma NA BeFree Detail
<0.001 Low Grade Lymphoma (neoplasm) NA BeFree Detail
0.001 T-Cell Lymphoma Our findings demonstrate that while deletions on chromosomes 4 and 11 affecting ... BeFree 26141385 Detail
0.121 Lymphoma, T-Cell, Cutaneous NA BeFree,CTD_human Detail
0.001 Pleural Effusion, Malignant NA BeFree Detail
<0.001 severe combined immunodeficiency NA BeFree Detail
0.005 Neoplasms, Second Primary NA BeFree,GAD Detail
<0.001 gestational diabetes NA BeFree Detail
0.001 Li-Fraumeni syndrome NA BeFree Detail
<0.001 Neurofibrillary degeneration (morphologic abnormality) NA BeFree Detail
0.004 acute leukemia p19ARF is a critical mediator of both cellular senescence and an innate immune r... BeFree 25784651 Detail
<0.001 Chronic cholecystitis NA BeFree Detail
<0.001 Chronic gastritis NA BeFree Detail
0.002 benign neoplasm NA BeFree Detail
<0.001 Rous Sarcoma NA BeFree Detail
<0.001 Sicca Syndrome NA BeFree Detail
0.007 Pancreatitis, Chronic NA BeFree,LHGDN Detail
0.002 Epstein-Barr Virus Infections NA BeFree Detail
0.002 Squamous cell carcinoma of lung Correlation between squamous cell carcinoma of the lung and human papillomavirus... BeFree 25544708 Detail
0.004 Small cell carcinoma of lung NA BeFree Detail
<0.001 Atrophic condition of skin NA BeFree Detail
0.003 Oral Cavity Carcinoma NA BeFree,GAD Detail
0.144 Cutaneous Melanoma This is the first estimate of the contribution of BAP1 and CDK4 to a population-... BeFree,CTD_human,GAD 25787093 Detail
0.144 Cutaneous Melanoma To conclude, we propose that mutation screening of CDKN2A and CDK4 in Denmark sh... BeFree,CTD_human,GAD 25803691 Detail
0.002 Adenocarcinoma of lung (disorder) Two-hit inactivation of CDKN2A and CDKN2B occurs frequently in patients with mut... BeFree 24618618 Detail
0.005 esophageal carcinoma Thus, p16 hypermethylation may aid as a biomarker in identifying habitués at gre... BeFree 25361631 Detail
<0.001 congenital heart disease NA BeFree Detail
<0.001 Malignant neoplasm of tongue Risk stratification of early stage oral tongue cancers based on HPV status and p... BeFree 25339028 Detail
0.005 Malignant neoplasm of mouth NA BeFree Detail
0.004 Malignant neoplasm of oropharynx The majority of North American respondents in this survey systematically test fo... BeFree 25096827 Detail
0.004 Malignant neoplasm of oropharynx Interestingly, the prognostic significance of p16 overexpression is different fr... BeFree 25339028 Detail
0.004 Malignant neoplasm of oropharynx Among these biomarkers, p53 is the strongest prognostic marker in OPC and p53 in... BeFree 25380690 Detail
0.004 Malignant neoplasm of oropharynx Significant correlations were confirmed between p16 positivity and oropharyngeal... BeFree 25503184 Detail
0.004 Malignant neoplasm of oropharynx Overall, this study provides evidence of epigenetic changes to the downstream re... BeFree 25619363 Detail
0.004 Malignant neoplasm of oropharynx Population-based p16 and HPV positivity rates in oropharyngeal cancer in Southea... BeFree 26152733 Detail
<0.001 Malignant neoplasm of nasopharynx We here evaluated p16 INK4A as a prognostic marker of treatment response and sur... BeFree 25640361 Detail
<0.001 Hypopharyngeal Cancer NA BeFree Detail
<0.001 Malignant neoplasm of anus We evaluated combined HPV DNA and p16 status as a prognostic factor of treatment... BeFree 26530750 Detail
0.001 Malignant neoplasm of gallbladder NA BeFree Detail
<0.001 uterine cancer NA BeFree Detail
<0.001 Malignant neoplasm of penis Thus, patients with P16(ink4a) negative penile cancer, particularly those with l... BeFree 25261804 Detail
<0.001 Malignant neoplasm of brain NA BeFree Detail
<0.001 Secondary malignant neoplasm of lung NA BeFree Detail
0.002 Malnutrition NA GAD Detail
0.003 Neurofibromatoses NA BeFree,LHGDN Detail
<0.001 Agenesis of corpus callosum NA BeFree Detail
<0.001 Autoimmune thyroid disease NA BeFree Detail
<0.001 Glomerulosclerosis (disorder) NA BeFree Detail
0.024 Tumor Progression HPV infection appears to be involved in cancer progression in SQC by promoting t... BeFree 25544708 Detail
<0.001 Microinvasive tumor NA BeFree Detail
<0.001 follicular adenoma NA BeFree Detail
<0.001 Carcinoma, Spindle-Cell Copy number analyses by molecular inversion probe assays of the three spindle ce... BeFree 25713418 Detail
0.001 Undifferentiated carcinoma NA BeFree Detail
0.003 Familial Atypical Multiple Mole-Melanoma The p16-Leiden founder mutation in the CDKN2A gene is the most common cause of F... BeFree 26111702 Detail
0.007 Dysplastic Nevus NA BeFree,GAD Detail
<0.001 Liposarcoma, Dedifferentiated NA BeFree Detail
0.001 Germ cell tumor NA BeFree Detail
<0.001 Glandular Neoplasms NA BeFree Detail
<0.001 thymic carcinoma NA BeFree Detail
<0.001 Lichen Planus, Oral NA BeFree Detail
<0.001 Ki-1+ Anaplastic Large Cell Lymphoma NA BeFree Detail
<0.001 hepatoblastoma NA BeFree Detail
<0.001 Fibroadenoma NA BeFree Detail
<0.001 Sarcoma, Clear Cell NA BeFree Detail
<0.001 alveolar rhabdomyosarcoma NA BeFree Detail
0.007 embryonal carcinoma NA BeFree Detail
<0.001 germinoma NA BeFree Detail
0.004 Neuroectodermal Tumor, Primitive NA BeFree,LHGDN Detail
<0.001 teratocarcinoma NA BeFree Detail
<0.001 hepatocellular adenoma NA BeFree Detail
<0.001 Follicular thyroid carcinoma NA BeFree Detail
<0.001 sebaceous adenocarcinoma Nevertheless, p16 overexpression was found in 71.4% (10/14) of SCs, irrespective... BeFree 25468813 Detail
0.120 adrenocortical carcinoma NA BeFree,CTD_human Detail
0.001 Carcinoma, Endometrioid ECCCs had SCA-like features with rare expression of estrogen receptor/progestero... BeFree 25473756 Detail
<0.001 mucoepidermoid carcinoma NA BeFree Detail
<0.001 Carcinoma, Neuroendocrine NA BeFree Detail
<0.001 Carcinoma, Signet Ring Cell NA BeFree Detail
0.008 cholangiocarcinoma Exome and the following prevalence sequencing identified mutations of the BAP1, ... BeFree,GAD,LHGDN 24532422 Detail
<0.001 Cystadenocarcinoma, Mucinous NA BeFree Detail
0.003 Cystadenocarcinoma, Serous NA BeFree,GAD Detail
<0.001 Carcinoma, Large Cell NA BeFree Detail
0.002 verrucous carcinoma β-PV DNA was detected in 5/30 VC (16.7%) and in 18/30 normal tissue samples (60.... BeFree 24350715 Detail
0.002 verrucous carcinoma Diffuse p16 expression was associated with younger age at presentation (P<0.0001... BeFree 26171917 Detail
0.019 Cervical Intraepithelial Neoplasia In this study, high-risk HPV E6/E7 and p16 mRNA expression patterns in eighty-si... BeFree,LHGDN 24625757 Detail
0.019 Cervical Intraepithelial Neoplasia We also used immunohistochemistry (IHC) to detect the P16(INK4a) protein, the ex... BeFree,LHGDN 25120798 Detail
0.019 Cervical Intraepithelial Neoplasia Immunohistochemistry of p16INK4A staining shows nil (0/25) expression in the cer... BeFree,LHGDN 25361681 Detail
0.019 Cervical Intraepithelial Neoplasia P16INK4A and survivin: Diagnostic and prognostic markers in cervical intraepithe... BeFree,LHGDN 25910412 Detail
0.019 Cervical Intraepithelial Neoplasia PanHPVE4 and p16INK4a staining are complementary markers that could provide simp... BeFree,LHGDN 26379150 Detail
<0.001 Cystadenoma, Serous NA BeFree Detail
<0.001 Mucoepidermoid Tumor NA BeFree Detail
<0.001 ganglioglioma NA BeFree Detail
<0.001 inverted papilloma NA BeFree Detail
<0.001 gliosarcoma NA BeFree Detail
0.124 Nerve Sheath Tumors NA BeFree,CTD_human,LHGDN Detail
0.003 Melanoma, Amelanotic NA BeFree,GAD Detail
0.007 Rhabdoid Tumor NA BeFree,LHGDN Detail
<0.001 Neuroendocrine Tumors NA BeFree Detail
<0.001 childhood rhabdomyosarcoma NA BeFree Detail
<0.001 Adult Acute Myeloblastic Leukemia NA BeFree Detail
0.006 uveal melanoma Epigenetic regulation of p14ARF and p16INK4A expression in cutaneous and uveal m... BeFree,GAD 25497382 Detail
0.007 Lip and oral cavity carcinoma NA BeFree,GAD Detail
<0.001 Carcinoma of unknown primary NA BeFree Detail
<0.001 Metastatic malignant neoplasm to brain CDKN2A/B deletions were associated with multiple MBMs and frequently hypermethyl... BeFree 24968695 Detail
<0.001 Chondromyxoid fibroma NA BeFree Detail
0.003 pituitary-dependent Cushing's disease NA LHGDN Detail
<0.001 Premature aging syndrome NA BeFree Detail
<0.001 Malignant neoplasm of female breast NA BeFree Detail
0.001 gallbladder carcinoma NA BeFree Detail
0.028 pancreatic carcinoma Increasing knowledge about the molecular pathogenesis of the disease has shown t... BeFree 24976721 Detail
0.028 pancreatic carcinoma Our results strongly support that the deletion of RD may represent a novel mecha... BeFree 25003221 Detail
0.028 pancreatic carcinoma Our results show that the clinical candidate AKT inhibitor MK-2206 promotes ARF ... BeFree 25071014 Detail
0.028 pancreatic carcinoma Studies of the molecular pathology of pancreatic cancer have revealed that activ... BeFree 25152585 Detail
0.028 pancreatic carcinoma The p16-Leiden germline variant in the CDKN2A gene is associated with a high ris... BeFree 25227142 Detail
0.028 pancreatic carcinoma This review presents current evidence regarding both senescence induction and es... BeFree 25461770 Detail
0.013 Gastrointestinal Stromal Tumors NA BeFree,LHGDN Detail
<0.001 Cancer of Nasopharynx We here evaluated p16 INK4A as a prognostic marker of treatment response and sur... BeFree 25640361 Detail
0.002 Squamous cell carcinoma of penis Lack of P16ink4a over expression in penile squamous cell carcinoma is associated... BeFree 25261804 Detail
0.002 Squamous cell carcinoma of penis HR-HPV(+) PSCCs overexpressed p16(INK4a) in 88% cases and p53 in 35% of cases, w... BeFree 25455689 Detail
0.002 Squamous cell carcinoma of penis The role of histologic subtype, p16(INK4a) expression, and presence of human pap... BeFree 25885064 Detail
<0.001 Anaplastic thyroid carcinoma NA BeFree Detail
<0.001 Papillary thyroid carcinoma NA BeFree Detail
<0.001 Squamous cell carcinoma of the vagina NA BeFree Detail
<0.001 Fibrosis, Liver NA BeFree Detail
<0.001 Interstitial fibrosis NA BeFree Detail
<0.001 Hepatitis, Autoimmune NA BeFree Detail
<0.001 islet cell tumor NA BeFree Detail
0.038 Malignant neoplasm of lung Furthermore, comparative analysis of mutant Kras;Cdkn2a null with Kras;Cdkn2ab n... BeFree,GAD 24618618 Detail
0.038 Malignant neoplasm of lung A cross-sectional study was conducted in which the methylation status of DAPK, C... BeFree,GAD 25069886 Detail
0.038 Malignant neoplasm of lung In the present study, the diagnostic utility of the SHOX2 assay was tested with ... BeFree,GAD 25331797 Detail
0.038 Malignant neoplasm of lung ANRIL, a lncRNA co-clustered mainly with p14/ARF has been reported to be dysregu... BeFree,GAD 25966845 Detail
0.003 Neoplasm, Residual NA BeFree,LHGDN Detail
<0.001 Isochromosomes NA BeFree Detail
0.005 Mucosa-Associated Lymphoid Tissue Lymphoma NA BeFree,LHGDN Detail
<0.001 Malignant Meningioma NA BeFree Detail
<0.001 Multiple tumors NA BeFree Detail
0.005 Carcinoma, Small Cell NA BeFree,LHGDN Detail
<0.001 parathyroid adenoma NA BeFree Detail
<0.001 Vagina Carcinoma NA BeFree Detail
<0.001 spongiotic dermatitis NA BeFree Detail
<0.001 Psoriasis vulgaris NA BeFree Detail
0.011 Acute respiratory failure NA BeFree Detail
<0.001 Renal sclerosis with hypertension NA BeFree Detail
<0.001 Secondary pulmonary hypertension NA BeFree Detail
<0.001 Turcot syndrome (disorder) NA BeFree Detail
<0.001 Chronic Periodontitis NA BeFree Detail
<0.001 Gastric dysplasia NA BeFree Detail
<0.001 Superficial gastritis NA BeFree Detail
<0.001 Carcinoma breast stage IV NA BeFree Detail
<0.001 Non-small cell lung cancer stage I NA BeFree Detail
<0.001 Non-small cell lung cancer stage II NA BeFree Detail
<0.001 recurrent childhood acute lymphoblastic leukemia NA BeFree Detail
<0.001 extramedullary plasmacytoma NA BeFree Detail
<0.001 Neuroblastoma recurrent NA BeFree Detail
0.002 gastric adenocarcinoma NA BeFree Detail
0.001 Malignant Childhood Neoplasm NA BeFree Detail
<0.001 Adenocarcinoma of small intestine NA BeFree Detail
<0.001 Growth Hormone-Producing Pituitary Gland Neoplasm NA BeFree Detail
0.002 Metastatic melanoma BRAF mutation and CDKN2A loss occurred early and TERT promoter mutation later in... BeFree 25407517 Detail
<0.001 Non-small cell lung cancer metastatic NA BeFree Detail
0.015 Cancer of Head and Neck Frequency of genetic and epigenetic alterations of p14ARF and p16INK4A in head a... BeFree,GAD 24710824 Detail
0.015 Cancer of Head and Neck Combination of p16(INK4a) /Ki67 immunocytology and HPV polymerase chain reaction... BeFree,GAD 25557267 Detail
0.015 Cancer of Head and Neck P16(INK4A) expression and HGAOT are independent prognostic factors for OS of pat... BeFree,GAD 25575976 Detail
0.015 Cancer of Head and Neck HPV-associated p16 INK4A expression and response to therapy and survival in sele... BeFree,GAD 25640361 Detail
0.015 Cancer of Head and Neck p16INK4a Status and Response to Induction Low-Dose Fractionated Radiation in Adv... BeFree,GAD 25810339 Detail
0.001 Liver and Intrahepatic Biliary Tract Carcinoma NA BeFree Detail
0.001 T-cell childhood acute lymphoblastic leukemia NA BeFree Detail
0.133 Squamous cell carcinoma of esophagus The results of this study suggested that MDM2 and p16 are predictive markers for... BeFree,CTD_human,GAD 25880782 Detail
0.125 Adenocarcinoma Of Esophagus Reanalysis of additional EAC exome data showed that the majority (62.5%) of EACs... BeFree,CTD_human 26192918 Detail
<0.001 anal carcinoma We evaluated combined HPV DNA and p16 status as a prognostic factor of treatment... BeFree 26530750 Detail
<0.001 gallbladder adenocarcinoma These results indicate that p16, p63 and p53 can be used as prognostic markers i... BeFree 24178677 Detail
0.001 cervical squamous cell carcinoma P16INK4A and survivin: Diagnostic and prognostic markers in cervical intraepithe... BeFree 25910412 Detail
<0.001 cervical adenocarcinoma NA BeFree Detail
<0.001 Small cell carcinoma of the cervix NA BeFree Detail
<0.001 Transitional cell carcinoma of bladder NA BeFree Detail
<0.001 bladder squamous cell carcinoma NA BeFree Detail
<0.001 bladder adenocarcinoma The expression patterns of p53 and p16 and an analysis of a possible role of HPV... BeFree 24752337 Detail
<0.001 Conventional (Clear Cell) Renal Cell Carcinoma Changes in PTEN and CDKN2A gene sets were associated with worsened prognosis of ... BeFree 25853938 Detail
<0.001 extraosseous Ewings sarcoma-primitive neuroepithelial tumor NA BeFree Detail
0.004 Solid tumour NA BeFree Detail
<0.001 stage, non-small cell lung cancer NA BeFree Detail
0.007 Squamous cell carcinoma of oropharynx The combination of both HPV-DNA sequencing analysis and immunohistochemistry (IH... BeFree 25399886 Detail
0.007 Squamous cell carcinoma of oropharynx We assessed a population-based cohort of patients diagnosed with oropharyngeal s... BeFree 26152733 Detail
0.007 Squamous cell carcinoma of oropharynx The authors explored the prognostic significance of heregulin/HER3 expression in... BeFree 26195293 Detail
0.001 Squamous cell carcinoma of tonsil We applied HPV DNA PCR and p16 immunohistochemistry to all TSCCs registered in t... BeFree 25283302 Detail
0.003 laryngeal squamous cell carcinoma P16(INK⁴a) overexpression is associated with CDKN2A mutation and worse prognosis... BeFree 25652585 Detail
0.003 laryngeal squamous cell carcinoma Frequency and prognostic significance of p16(INK4A) protein overexpression and t... BeFree 25688737 Detail
<0.001 high-grade childhood cerebral astrocytoma NA BeFree Detail
<0.001 diffuse astrocytoma NA BeFree Detail
<0.001 anaplastic ependymoma NA BeFree Detail
<0.001 mixed oligodendroglioma-astrocytoma After adjustment for IDH mutation, sex, and age, CDKN2A deletion was strongly as... BeFree 25853694 Detail
<0.001 Primary central nervous system lymphoma NA BeFree Detail
0.002 Squamous cell carcinoma of vulva p16INK4A expression could be used as a useful marker for HPV positivity in vagin... BeFree 25605180 Detail
0.004 Adenocarcinoma of pancreas NA BeFree Detail
<0.001 benign meningioma NA BeFree Detail
<0.001 Myomatous neoplasm NA BeFree Detail
<0.001 Condyloma NA BeFree Detail
0.016 cervix carcinoma Human papilloma virus early proteins E6 (HPV16/18-E6) and the cell cycle marker ... BeFree 24925218 Detail
0.016 cervix carcinoma Immunohistochemistry of p16INK4A staining shows nil (0/25) expression in the cer... BeFree 25361681 Detail
0.016 cervix carcinoma Medline, Embase and China National Knowledge Infrastructures were searched to id... BeFree 25461355 Detail
0.016 cervix carcinoma Methylation of the p16(INK4a) gene occurs early in the development of cervical c... BeFree 25579180 Detail
0.016 cervix carcinoma p16INK4A expression could be used as a useful marker for HPV positivity in vagin... BeFree 25605180 Detail
0.016 cervix carcinoma Moreover, p16 protein was associated with CIN grade and lymph node metastases in... BeFree 25910412 Detail
<0.001 Superficial ulcer NA BeFree Detail
0.001 Tumor necrosis NA BeFree Detail
0.002 Squamous intraepithelial lesion NA BeFree Detail
0.007 High-Grade Squamous Intraepithelial Lesions The combination TOP2A and CDKN2A/p16 has a good balance between sensitivity and ... BeFree 25189639 Detail
0.007 High-Grade Squamous Intraepithelial Lesions A marker with high sensitivity and specificity for the detection of HSIL in cerv... BeFree 25862555 Detail
0.001 Hyperplastic Polyp NA BeFree Detail
<0.001 Multiple polyps NA BeFree Detail
<0.001 Papillary squamous cell carcinoma NA BeFree Detail
<0.001 Squamous cell carcinoma, metastatic NA BeFree Detail
<0.001 Squamous cell carcinoma, keratinizing NA BeFree Detail
<0.001 Transitional cell carcinoma in situ NA BeFree Detail
<0.001 adenocarcinoma in situ NA BeFree Detail
<0.001 tubular adenomas and adenocarcinomas NA BeFree Detail
<0.001 Carcinoid tumor no ICD-O subtype NA BeFree Detail
<0.001 Nodular melanoma NA BeFree Detail
<0.001 Superficial spreading malignant melanoma of skin Compared with CDKN2A(-) cases, mutation carriers tended to have histologic featu... BeFree 25592620 Detail
0.003 malignant fibrous histiocytoma NA BeFree,LHGDN Detail
<0.001 Proliferating Brenner Tumor NA BeFree Detail
<0.001 myxoid chondrosarcoma NA BeFree Detail
0.003 anaplastic astrocytoma NA BeFree Detail
0.002 pilocytic astrocytoma NA BeFree Detail
0.004 anaplastic oligodendroglioma Within the 1p/19q-codeleted AO, the contrast enhancement was associated with lar... BeFree 24353325 Detail
0.004 anaplastic oligodendroglioma After adjustment for IDH mutation, sex, and age, CDKN2A deletion was strongly as... BeFree 25853694 Detail
0.006 Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse High-dose cytarabine does not overcome the adverse prognostic value of CDKN2A an... BeFree,LHGDN 26022239 Detail
<0.001 histiocytic sarcoma NA BeFree Detail
<0.001 Glaucoma, Primary Open Angle Evaluation of genetic association of the INK4 locus with primary open angle glau... BeFree 24875940 Detail
<0.001 Internal Carotid Artery Stenosis The severity of internal carotid artery stenosis is associated with the cyclin-d... BeFree 24599170 Detail
<0.001 Aortic aneurysm without mention of rupture NOS NA BeFree Detail
0.004 Human papilloma virus infection Detection of human papillomavirus infection and p16 immunohistochemistry express... BeFree 24675970 Detail
0.004 Human papilloma virus infection Correlation between squamous cell carcinoma of the lung and human papillomavirus... BeFree 25544708 Detail
0.004 Human papilloma virus infection Frequency and prognostic significance of p16(INK4A) protein overexpression and t... BeFree 25688737 Detail
<0.001 Carcinoma ex pleomorphic adenoma NA BeFree Detail
0.001 Malignant neoplasm of liver NA BeFree Detail
<0.001 intrahepatic cholangiocarcinoma Given overexpression of a polycomb group protein EZH2 in intrahepatic cholangioc... BeFree 25289642 Detail
<0.001 Angiosarcoma of liver NA BeFree Detail
0.005 malignant mesothelioma NA BeFree Detail
<0.001 Stage 0 Skin Melanoma NA BeFree Detail
0.003 Vulval intraepithelial neoplasia Diffuse p16 expression was associated with younger age at presentation (P<0.0001... BeFree 26171917 Detail
<0.001 Malignant melanoma of iris NA BeFree Detail
<0.001 Malignant neoplasm of adrenal cortex NA BeFree Detail
0.035 Malignant neoplasm of pancreas Increasing knowledge about the molecular pathogenesis of the disease has shown t... BeFree,GAD 24976721 Detail
0.035 Malignant neoplasm of pancreas Our results strongly support that the deletion of RD may represent a novel mecha... BeFree,GAD 25003221 Detail
0.035 Malignant neoplasm of pancreas Our results show that the clinical candidate AKT inhibitor MK-2206 promotes ARF ... BeFree,GAD 25071014 Detail
0.035 Malignant neoplasm of pancreas Studies of the molecular pathology of pancreatic cancer have revealed that activ... BeFree,GAD 25152585 Detail
0.035 Malignant neoplasm of pancreas The p16-Leiden germline variant in the CDKN2A gene is associated with a high ris... BeFree,GAD 25227142 Detail
0.035 Malignant neoplasm of pancreas This review presents current evidence regarding both senescence induction and es... BeFree,GAD 25461770 Detail
<0.001 Disseminated Malignant Neoplasm NA BeFree Detail
0.002 Anal intraepithelial neoplasia NA BeFree Detail
<0.001 Carcinoma in situ of fallopian tube Stathmin 1 and p16(INK4A) are sensitive adjunct biomarkers for serous tubal intr... BeFree 26206555 Detail
<0.001 Penile intraepithelial neoplasia NA BeFree Detail
<0.001 Cervix adenomatous polyp NA BeFree Detail
0.005 Cervical intraepithelial neoplasia grade 1 NA BeFree Detail
0.005 Cervical intraepithelial neoplasia grade 2 Compared with high-risk HPV genotyping, p16(INK4a)/Ki-67 immunocytochemistry was... BeFree 24744261 Detail
<0.001 gastric lymphoma NA BeFree Detail
<0.001 Carcinoma of anal margin By contrast, p16 negatively, but not HPV 16 genotype, is an independent adverse ... BeFree 25702585 Detail
<0.001 Vaginal intraepithelial neoplasia grade 1 NA BeFree Detail
<0.001 Vulval intraepithelial neoplasia grade 3 NA BeFree Detail
<0.001 Squamous cell carcinoma of tongue To combine clinical and molecular markers into an algorithm for predicting outco... BeFree 26025766 Detail
<0.001 Pleomorphic adenoma of parotid gland NA BeFree Detail
<0.001 Richter's syndrome NA BeFree Detail
<0.001 juvenile myelomonocytic leukemia NA BeFree Detail
0.002 Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site NA BeFree Detail
<0.001 Human T-cell lymphotrophic virus, type I [HTLV-I] NA BeFree Detail
0.001 Malignant neoplasm of vulva NA BeFree Detail
0.006 Malignant neoplasm of prostate Association of p16 gene methylation with prostate cancer risk: a meta-analysis. BeFree 26416059 Detail
0.002 Hematopoietic Neoplasms NA BeFree Detail
0.007 Hematologic Neoplasms NA BeFree,LHGDN Detail
<0.001 Hereditary hemochromatosis NA BeFree Detail
0.360 melanoma An assessment of the CDKN2A variant Ala148Thr as a nevus/melanoma susceptibility... BeFree 12406345 Detail
0.002 Benign melanocytic nevus An assessment of the CDKN2A variant Ala148Thr as a nevus/melanoma susceptibility... BeFree 12406345 Detail
<0.001 Nijmegen breakage syndrome NA BeFree Detail
0.144 Cutaneous Melanoma The CDKN2A p.A148T variant is associated with cutaneous melanoma in Southern Bra... BeFree 21895773 Detail
0.360 melanoma The CDKN2A p.A148T variant is associated with cutaneous melanoma in Southern Bra... BeFree 21895773 Detail
0.007 Nevus An assessment of the CDKN2A variant Ala148Thr as a nevus/melanoma susceptibility... BeFree 12406345 Detail
0.023 breast carcinoma In the total set of 189 patients we found a novel change Pro48Arg (nt 143 c &gt;... BeFree 18714178 Detail
0.007 Melanocytic nevus An assessment of the CDKN2A variant Ala148Thr as a nevus/melanoma susceptibility... BeFree 12406345 Detail
0.001 Melanocytic nevus of skin An assessment of the CDKN2A variant Ala148Thr as a nevus/melanoma susceptibility... BeFree 12406345 Detail
0.023 breast carcinoma The CDKN2A A148T variant seems to contribute to early-onset breast cancer in Pol... BeFree 17061045 Detail
0.360 melanoma The CDKN2a common variants: 148 Ala/Thr and 500 C/G in 3' UTR, and their associa... BeFree 17351674 Detail
0.043 Malignant neoplasm of breast In the total set of 189 patients we found a novel change Pro48Arg (nt 143 c &gt;... BeFree 18714178 Detail
0.360 melanoma In the total set of 189 patients we found a novel change Pro48Arg (nt 143 c &gt;... BeFree 18714178 Detail
<0.001 Chronic rejection of renal transplant NA BeFree Detail
<0.001 Poikiloderma of Kindler NA BeFree Detail
<0.001 Developmental delay (disorder) NA BeFree Detail
<0.001 Atypical meningioma NA BeFree Detail
<0.001 Chromosome 9, trisomy NA BeFree Detail
<0.001 Post-transplant lymphoproliferative disorder NA BeFree Detail
<0.001 Follicular neoplasm NA BeFree Detail
<0.001 Plasma cell tumor, malignant NA BeFree Detail
0.004 endometrial carcinoma Aberrant promoter hypermethylation of p16 gene in endometrial carcinoma. BeFree 25596080 Detail
0.002 Secondary malignant neoplasm of liver NA BeFree Detail
0.002 physical function NA GAD Detail
<0.001 Sleep Apnea, Obstructive NA BeFree Detail
0.002 Recurrent tumor NA BeFree Detail
<0.001 Neurodegenerative Disorders NA BeFree Detail
<0.001 Hepatitis C, Chronic NA BeFree Detail
0.010 Malignant neoplasm of esophagus Thus, p16 hypermethylation may aid as a biomarker in identifying habitués at gre... BeFree,GAD 25361631 Detail
<0.001 Recurrent Carcinoma NA BeFree Detail
0.003 Thyroid carcinoma NA BeFree Detail
0.004 Oropharynx (excludes nasopharynx) In total, 24% of the HNSCCUP patients were p16 positive. p16 overexpression in n... BeFree 24993345 Detail
0.004 Oropharynx (excludes nasopharynx) No association between KRAS-variant status and p16 expression was observed in th... BeFree 25081901 Detail
0.004 Oropharynx (excludes nasopharynx) Among those HNSCCs that were positive for HR-HPV, 18 (100%) of 18 originated fro... BeFree 25873503 Detail
0.004 Oropharynx (excludes nasopharynx) HPV E7 seropositivity correlated with positive tumor HPV-DNA and p16 expression,... BeFree 26116154 Detail
0.003 Ewings sarcoma Strikingly, STAG2 mutations and CDKN2A deletions were mutually exclusive, as con... BeFree 25223734 Detail
0.003 Ewings sarcoma A growing collection of retrospective studies have suggested that TP53 mutations... BeFree 25464386 Detail
0.005 Oropharyngeal disorders MiR-34a tumor levels significantly correlated with oropharyngeal origin (p=0.028... BeFree 25862914 Detail
0.005 Oropharyngeal disorders Immunohistochemistry for p16 protein is often used as a surrogate marker for onc... BeFree 26650695 Detail
0.002 Squamous cell carcinoma of skin NA BeFree Detail
0.006 Malignant glioma NA BeFree Detail
<0.001 tongue carcinoma Risk stratification of early stage oral tongue cancers based on HPV status and p... BeFree 25339028 Detail
0.001 Tonsillar Carcinoma NA BeFree Detail
<0.001 Malignant melanoma of eye NA BeFree Detail
<0.001 primary sclerosing cholangitis NA BeFree Detail
<0.001 Carotid Atherosclerosis In addition, the p16(INK4a) expression is associated with carotid atherosclerosi... BeFree 24599170 Detail
<0.001 Squamous cell carcinoma of mouth NA BeFree Detail
0.005 Osteosarcoma of bone Further, we could deduce genes with possible prognostic significance in OS for f... BeFree 25848766 Detail
<0.001 Costello syndrome (disorder) The role of p19 and p21 H-Ras proteins and mutants in miRNA expression in cancer... BeFree 26138095 Detail
<0.001 Intraocular pressure disorder Our data indicate that SIX6 and/or IOP promotes POAG by directly increasing p16I... BeFree 26365380 Detail
0.028 pancreatic carcinoma To verify the S305N association with melanoma risk in an independent larger Fren... BeFree 21507037 Detail
<0.001 Carcinoma of larynx NA BeFree Detail
0.360 melanoma To verify the S305N association with melanoma risk in an independent larger Fren... BeFree 21507037 Detail
0.035 Malignant neoplasm of pancreas To verify the S305N association with melanoma risk in an independent larger Fren... BeFree 21507037 Detail
0.080 Carcinogenesis These results indicate that RD deletion and BMI1 overexpression frequently occur... BeFree 24302590 Detail
0.080 Carcinogenesis Slug regulates E-cadherin repression via p19Arf in prostate tumorigenesis. BeFree 24910389 Detail
0.080 Carcinogenesis Cooperativity of oncogenic K-ras and downregulated p16/INK4A in human pancreatic... BeFree 25029561 Detail
0.080 Carcinogenesis Deletion of Ptprd and Cdkn2a cooperate to accelerate tumorigenesis. BeFree 25138050 Detail
0.080 Carcinogenesis p16(INK4a) is a tumor suppressor gene, frequently hypermethylated in breast canc... BeFree 25344837 Detail
0.080 Carcinogenesis There is a need for identification of biomarkers to identify people at risk of e... BeFree 25361631 Detail
0.080 Carcinogenesis The aim of this study was to investigate promoter methylation of certain tumor s... BeFree 25417611 Detail
0.080 Carcinogenesis We hypothesize that the presence of the fourth product, pALT(INK4a/b) of the INK... BeFree 25550505 Detail
0.080 Carcinogenesis We have shown that an epigenetic diet can influence both cellular longevity and ... BeFree 25568452 Detail
0.080 Carcinogenesis Regarding the oncogenesis of primary brain tumors, it was shown that changes in ... BeFree 26124340 Detail
<0.001 Chemical Carcinogenesis NA BeFree Detail
<0.001 Biliary stricture NA BeFree Detail
0.004 Leukemogenesis NA BeFree Detail
<0.001 Lymphoid neoplasm NA BeFree Detail
<0.001 Infective cystitis NA BeFree Detail
0.006 prostate carcinoma Association of increased levels of TGF-β1 and p14ARF in prostate carcinoma cell ... BeFree 25224321 Detail
0.006 prostate carcinoma Association of p16 gene methylation with prostate cancer risk: a meta-analysis. BeFree 26416059 Detail
0.002 hepatopulmonary syndrome NA GAD Detail
0.002 CARCINOMA OF VULVA However, our data support the presence of 2 different mechanisms for p16INK4A ex... BeFree 25605180 Detail
<0.001 Gastro-esophageal reflux disease with esophagitis NA BeFree Detail
<0.001 Hereditary Breast and Ovarian Cancer Syndrome NA BeFree Detail
0.120 Brain Stem Neoplasms NA CTD_human Detail
0.006 Epithelial ovarian cancer p16/CDKN2A FISH in Differentiation of Diffuse Malignant Peritoneal Mesothelioma ... BeFree,GAD 25972325 Detail
0.002 invasive cancer NA BeFree Detail
<0.001 Progressive Neoplastic Disease NA BeFree Detail
<0.001 Locally Advanced Malignant Neoplasm Six genes were differentially expressed in patients with localized and locally a... BeFree 26408707 Detail
0.023 breast carcinoma In a cross-sectional study of 138 women with no history of breast cancer who und... BeFree 25344837 Detail
<0.001 Lesion of stomach NA BeFree Detail
0.030 Carcinoma of lung Furthermore, comparative analysis of mutant Kras;Cdkn2a null with Kras;Cdkn2ab n... BeFree,GAD 24618618 Detail
0.030 Carcinoma of lung A cross-sectional study was conducted in which the methylation status of DAPK, C... BeFree,GAD 25069886 Detail
0.030 Carcinoma of lung In the present study, the diagnostic utility of the SHOX2 assay was tested with ... BeFree,GAD 25331797 Detail
0.030 Carcinoma of lung ANRIL, a lncRNA co-clustered mainly with p14/ARF has been reported to be dysregu... BeFree,GAD 25966845 Detail
<0.001 Ewings sarcoma-primitive neuroectodermal tumor (PNET) NA BeFree Detail
<0.001 Malignant neoplasm of gastrointestinal tract NA BeFree Detail
0.010 Secondary malignant neoplasm of lymph node Patients with a lower alcohol consumption, only level II/III metastasis, and cys... BeFree 24993345 Detail
0.010 Secondary malignant neoplasm of lymph node The results showed that the membrane weighted index of β-catenin was inversely c... BeFree 25209444 Detail
0.010 Secondary malignant neoplasm of lymph node Thus, patients with P16(ink4a) negative penile cancer, particularly those with l... BeFree 25261804 Detail
0.010 Secondary malignant neoplasm of lymph node Moreover, p16 protein was associated with CIN grade and lymph node metastases in... BeFree 25910412 Detail
<0.001 extranodal lymphoma NA BeFree Detail
0.005 colon carcinoma Molecular subtypes in stage II-III colon cancer defined by genomic instability: ... BeFree 25879218 Detail
0.017 stomach carcinoma Cell-cycle regulation was affected by aberrant methylation of CDKN2A and CHFR in... BeFree 24510342 Detail
0.017 stomach carcinoma The present results indicated that the methylation of p16, CDH1, MGMT, and hMLH1... BeFree 24816738 Detail
0.017 stomach carcinoma The relationship between P16 gene promoter methylation and gastric cancer: a met... BeFree 25693938 Detail
0.017 stomach carcinoma ANRIL, a lncRNA co-clustered mainly with p14/ARF has been reported to be dysregu... BeFree 25966845 Detail
0.017 stomach carcinoma Moreover, their combined treatment synergistically arrested GC cells at G0/G1 ph... BeFree 26173505 Detail
0.015 Carcinoma of bladder Detection of human papillomavirus infection and p16 immunohistochemistry express... BeFree 24675970 Detail
0.015 Carcinoma of bladder Transfection of the DNAzyme caused significant down-regulation of DNMT1 expressi... BeFree 25888794 Detail
0.002 skin carcinoma NA BeFree Detail
0.006 Central neuroblastoma NA BeFree Detail
<0.001 Dissecting aneurysm of the thoracic aorta NA BeFree Detail
<0.001 bile duct carcinoma NA BeFree Detail
<0.001 Malignant neoplasm of kidney NA BeFree Detail
<0.001 anal cancer squamous cell Prognostic Relevance of HPV Infection and p16 Overexpression in Squamous Cell An... BeFree 26530750 Detail
<0.001 Poorly differentiated carcinoma NA BeFree Detail
<0.001 cervical cancer squamous cell NA BeFree Detail
<0.001 gastritis h pylori NA BeFree Detail
<0.001 biliary tract cancer NA BeFree Detail
<0.001 Brain Tumor, Primary Distribution and Effects of CDKN2 p16 540 C>G and 580 C>T, and MDM2 SNP309 T>G P... BeFree 26124340 Detail
<0.001 Primary malignant neoplasm of brain NA BeFree Detail
0.004 Well Differentiated Oligodendroglioma After adjustment for IDH mutation, sex, and age, CDKN2A deletion was strongly as... BeFree 25853694 Detail
<0.001 Malignant neoplasm tonsil NA BeFree Detail
0.002 adult acute lymphocytic leukemia The p16(INK4A)/pRb pathway and telomerase activity define a subgroup of Ph+ adul... BeFree 25675863 Detail
<0.001 Basal Cell Cancer NA BeFree Detail
0.004 Malignant Squamous Cell Neoplasm The p14 promoter was unmethylated in 86.7 % of OSCC and in 85.7 % of LSCC patien... BeFree 24710824 Detail
0.004 Malignant Squamous Cell Neoplasm Development of squamous cell cancer of head and neck (SCCHN) is associated with ... BeFree 25640361 Detail
0.005 malignant peripheral nerve sheath tumor Genetic inactivation of PRC2 components, NF1, and CDKN2A are frequently detected... BeFree 25367955 Detail
<0.001 Chromosome 10, monosomy 10q NA BeFree Detail
0.004 malignant pleural mesothelioma MDM2 is an important prognostic and predictive factor for platin-pemetrexed ther... BeFree 25668009 Detail
<0.001 psychological distress NA BeFree Detail
<0.001 Spots on skin Polysomy 6 and p16 deletion were significantly more frequent in noninvasive than... BeFree 25517961 Detail
0.002 Helicobacter pylori infection NA BeFree Detail
0.002 Carcinoma in situ of uterine cervix NA BeFree Detail
<0.001 Arteriopathic disease NA BeFree Detail
<0.001 penis carcinoma Thus, patients with P16(ink4a) negative penile cancer, particularly those with l... BeFree 25261804 Detail
<0.001 Invasive breast carcinoma NA BeFree Detail
<0.001 Pineal germinoma NA BeFree Detail
<0.001 Carcinogenicity NA BeFree Detail
<0.001 Pancreatic adenocarcinoma metastatic NA BeFree Detail
<0.001 Mycosis fungoides/Sezary syndrome NOS NA BeFree Detail
<0.001 Borderline ovarian tumour NA BeFree Detail
<0.001 dedifferentiated chondrosarcoma NA BeFree Detail
<0.001 Ewing's tumour localised Tumoral TP53 and/or CDKN2A alterations are not reliable prognostic biomarkers in... BeFree 25464386 Detail
<0.001 Hyperkeratosis NA BeFree Detail
0.003 Intraepithelial Neoplasia NA BeFree Detail
<0.001 Gastric hyperplastic polyp NA BeFree Detail
0.123 Carcinoma, Pancreatic Ductal NA BeFree,CTD_human,GAD Detail
0.020 ovarian neoplasm NA BeFree,GAD,LHGDN Detail
<0.001 Metastatic Prostate Carcinoma NA BeFree Detail
0.003 precancerous lesions NA BeFree Detail
<0.001 Ischemic stroke NA BeFree Detail
<0.001 salivary gland carcinoma NA BeFree Detail
<0.001 Polyomavirus Infections NA BeFree Detail
0.003 Papillomavirus Infections NA BeFree,LHGDN Detail
<0.001 Plasma cell dyscrasia NA BeFree Detail
0.021 Malignant neoplasm of ovary NA BeFree,GAD Detail
0.140 Squamous cell carcinoma of the head and neck Alterations in RD(INK4/ARF) -mediated en bloc regulation of the INK4-ARF locus i... BeFree,CTD_human 24302590 Detail
0.140 Squamous cell carcinoma of the head and neck KRAS-variant genotyping was conducted for these samples and 8 HNSCC cell lines. ... BeFree,CTD_human 25081901 Detail
0.140 Squamous cell carcinoma of the head and neck North-American survey on HPV-DNA and p16 testing for head and neck squamous cell... BeFree,CTD_human 25096827 Detail
0.140 Squamous cell carcinoma of the head and neck All HPV oncogene-expressing HNSCC showed p16(INK4a) /Ki-67 co-expression. BeFree,CTD_human 25104331 Detail
0.140 Squamous cell carcinoma of the head and neck In conclusion, the data emphasize the urge for further data on HPV-infection in ... BeFree,CTD_human 25310104 Detail
0.140 Squamous cell carcinoma of the head and neck A simultaneous immunocytochemical detection of p16(INK4a) and Ki67 can reliably ... BeFree,CTD_human 25557267 Detail
0.140 Squamous cell carcinoma of the head and neck High-grade acute organ toxicity and p16(INK4A) expression as positive prognostic... BeFree,CTD_human 25575976 Detail
0.140 Squamous cell carcinoma of the head and neck To evaluate the impact of p16INK4a (p16) expression on clinical efficacy of indu... BeFree,CTD_human 25810339 Detail
0.140 Squamous cell carcinoma of the head and neck Human papillomavirus (HPV), p16 expression, and TP53 mutations are known prognos... BeFree,CTD_human 25871546 Detail
0.140 Squamous cell carcinoma of the head and neck Among those HNSCCs that were positive for HR-HPV, 18 (100%) of 18 originated fro... BeFree,CTD_human 25873503 Detail
0.140 Squamous cell carcinoma of the head and neck These results suggest that UGT2B17-deletion interacting with p16 (+) may modify ... BeFree,CTD_human 25886176 Detail
0.140 Squamous cell carcinoma of the head and neck Human papillomavirus E7 serology and association with p16 immunohistochemistry i... BeFree,CTD_human 26116154 Detail
<0.001 Ductal Carcinoma NA BeFree Detail
0.002 Chromosomal Instability NA GAD Detail
0.002 Glucose Metabolism Disorders NA GAD Detail
0.008 sarcoma NA BeFree,LHGDN Detail
<0.001 Persistent infection NA BeFree Detail
<0.001 large cell neuroendocrine carcinoma NA BeFree Detail
<0.001 basaloid squamous cell carcinoma NA BeFree Detail
<0.001 Traditional Serrated Adenoma However, CDKN2A (encoding the p16 protein) is silenced nearly exclusively in the... BeFree 25216220 Detail
<0.001 metanephric adenoma NA BeFree Detail
<0.001 Solitary fibrous tumor NA BeFree Detail
<0.001 Intracortical osteosarcoma NA BeFree Detail
<0.001 major depressive disorder NA BeFree Detail
<0.001 Primary cutaneous B-cell lymphoma NA BeFree Detail
<0.001 Familial multiple trichoepitheliomata NA BeFree Detail
<0.001 Avellino corneal dystrophy These accumulations were associated with decreased levels of Cyclin A1, B1, and ... BeFree 25450621 Detail
<0.001 Chronic leukemia (category) NA BeFree Detail
<0.001 Primary Effusion Lymphoma NA BeFree Detail
0.003 Precursor B-cell lymphoblastic leukemia NA BeFree Detail
<0.001 Chronic myeloproliferative disorder Dysregulation of the MIRLET7/HMGA2 axis with methylation of the CDKN2A promoter ... BeFree 25236537 Detail
<0.001 Therapy-related myelodysplastic syndrome NA BeFree Detail
<0.001 Single tumor NA BeFree Detail
<0.001 Pancreatic intraepithelial neoplasia NA BeFree Detail
<0.001 Salivary duct carcinoma NA BeFree Detail
<0.001 blastic plasmacytoid dendritic cell neoplasm NA BeFree Detail
0.001 Adenoma of large intestine NA BeFree Detail
<0.001 Melanocytic neoplasm Cdkn2a loss is associated with mTORC2 and Akt activation in human and murine mel... BeFree 25584893 Detail
0.007 Low Grade Squamous Intraepithelial Neoplasia Performance of p16INK4a/Ki-67 immunocytochemistry for identifying CIN2+ in atypi... BeFree 24744261 Detail
0.007 Low Grade Squamous Intraepithelial Neoplasia HPV DNA genotyping and methylation of gene p16 INK4A in cervical LSIL. BeFree 25579180 Detail
<0.001 ACTH-secreting pituitary adenoma NA BeFree Detail
<0.001 Adenocarcinoma of large intestine NA BeFree Detail
<0.001 Acute Myeloid Leukemia Arising from Previous Myelodysplastic Syndrome NA BeFree Detail
<0.001 Atypical Ductal Breast Hyperplasia NA BeFree Detail
<0.001 Brain Stem Astrocytoma NA BeFree Detail
<0.001 Cervical Squamous Intraepithelial Neoplasia NA BeFree Detail
0.001 Hereditary Malignant Neoplasm In specific PC populations, including in Italy, hereditary cancer predisposition... BeFree 25152581 Detail
<0.001 Flat Ductal Epithelial Atypia of the Breast NA BeFree Detail
<0.001 Gastric Mucosa-Associated Lymphoid Tissue Lymphoma NA BeFree Detail
<0.001 Hepatitis B Virus-Related Hepatocellular Carcinoma NA BeFree Detail
<0.001 Hereditary Nonpolyposis Colorectal Cancer NA BeFree Detail
<0.001 Hereditary Non-Polyposis Colon Cancer Type 2 NA BeFree Detail
0.003 High Grade Cervical Intraepithelial Neoplasia NA BeFree Detail
<0.001 High Grade Intraepithelial Neoplasia NA BeFree Detail
<0.001 indolent lymphoma NA BeFree Detail
<0.001 Infiltrating Cervical Carcinoma NA BeFree Detail
0.002 Invasive Carcinoma Copy number and loss of heterogeneity (LOH) profiles were similar in all six car... BeFree 25502898 Detail
<0.001 Large Cell Lung Neuroendocrine Carcinoma NA BeFree Detail
<0.001 Mucinous Neoplasm NA BeFree Detail
<0.001 Opisthorchis Viverrini-Related Cholangiocarcinoma NA BeFree Detail
<0.001 optic nerve astrocytoma NA BeFree Detail
0.004 pancreatic ductal adenocarcinoma Loss of the CDK4/6 inhibitor CDKN2A is a signature genetic event in PDA. BeFree 25156567 Detail
<0.001 Conventional Chondrosarcoma Isocitrate dehydrogenase 1 mutations (IDH1) and p16/CDKN2A copy number change in... BeFree 25432631 Detail
<0.001 Primary Carcinoma NA BeFree Detail
<0.001 Vulvar Intraepithelial Neoplasia, Differentiated Type NA BeFree Detail
<0.001 Sporadic Breast Carcinoma NA BeFree Detail
<0.001 Carcinoma of urinary bladder, superficial NA BeFree Detail
<0.001 supratentorial primitive neuroectodermal tumor NA BeFree Detail
<0.001 Well Differentiated Pancreatic Endocrine Tumor Deletions of RDINK4/ARF enhancer in gastrinomas and nonfunctioning pancreatic ne... BeFree 25003221 Detail
<0.001 differentiated thyroid gland carcinoma NA BeFree Detail
<0.001 Hypopharyngeal Carcinoma NA BeFree Detail
0.001 Epithelioma NA BeFree Detail
<0.001 Pleural Mesothelioma NA BeFree Detail
0.001 renal carcinoma NA BeFree Detail
<0.001 Metastatic Carcinoma NA BeFree Detail
<0.001 Primary Lesion In total, 24% of the HNSCCUP patients were p16 positive. p16 overexpression in n... BeFree 24993345 Detail
<0.001 Primary Lesion Germline CDKN2A mutations affecting p16(INK4a) were detected in 8 unrelated prob... BeFree 25023876 Detail
<0.001 anal squamous cell carcinoma By contrast, p16 negatively, but not HPV 16 genotype, is an independent adverse ... BeFree 25702585 Detail
<0.001 Chronic esophagitis NA BeFree Detail
<0.001 Cardiomyopathy, Familial Idiopathic NA BeFree Detail
0.120 Micronuclei, Chromosome-Defective NA CTD_human Detail
0.002 Benign melanocytic nevus NA BeFree Detail
0.158 Mammary Neoplasms NA BeFree,CTD_human,GAD,LHGDN Detail
<0.001 Angiogenic Switch NA BeFree Detail
0.006 Hepatocarcinogenesis NA BeFree Detail
0.145 Hereditary Melanoma Germline mutations in the tumour suppressor gene CDKN2A occur in 5-20% of famili... BeFree,CLINVAR,GAD 24935963 Detail
0.145 Hereditary Melanoma Germline CDKN2A mutations in Brazilian patients of hereditary cutaneous melanoma... BeFree,CLINVAR,GAD 25023876 Detail
0.145 Hereditary Melanoma Genetics of familial melanoma: 20 years after CDKN2A. BeFree,CLINVAR,GAD 25431349 Detail
0.145 Hereditary Melanoma Familial melanomas with CDKN2A mutations preferentially express a histologic phe... BeFree,CLINVAR,GAD 25592620 Detail
0.001 Cervical high grade squamous intraepithelial lesion NA BeFree Detail
<0.001 Mammary Tumorigenesis NA BeFree Detail
<0.001 Primary Glioblastoma NA BeFree Detail
<0.001 cholangiolocellular carcinoma A borderline between cholangiolocellular carcinoma and the surrounding ductular ... BeFree 25289642 Detail
<0.001 Low Grade Cervical Squamous Intraepithelial Neoplasia NA BeFree Detail
<0.001 Malignant Conversion NA BeFree Detail
<0.001 ovarian clear cell adenocarcinoma NA BeFree Detail
<0.001 Secondary Glioblastoma NA BeFree Detail
<0.001 Skin Carcinogenesis NA BeFree Detail
<0.001 Xenograft Model Our results show that the clinical candidate AKT inhibitor MK-2206 promotes ARF ... BeFree 25071014 Detail
0.036 colorectal cancer Investigation of IL-23 (p19, p40) and IL-23R identifies nuclear expression of IL... BeFree,GAD 25015728 Detail
0.036 colorectal cancer Combined methylation of p16 and hMLH1 (CMETH2) discriminates a subpopulation wit... BeFree,GAD 25576161 Detail
0.036 colorectal cancer An adenoviral construct of the human p14ARF gene (a tumor suppressor) and a 22 a... BeFree,GAD 25935465 Detail
<0.001 Ductal Breast Carcinoma NA BeFree Detail
<0.001 Neoplasms, Intracranial NA BeFree Detail
<0.001 smoldering myeloma NA BeFree Detail
0.001 Rash and Dermatitis Adverse Event Associated with Chemoradiation NA BeFree Detail
<0.001 Non-Malignant Ascites Adverse Event NA BeFree Detail
0.001 Adenocarcinoma, Endometrioid ECCCs had SCA-like features with rare expression of estrogen receptor/progestero... BeFree 25473756 Detail
0.002 Glioblastoma multiforme NA BeFree Detail
0.002 Cirrhosis NA BeFree Detail
<0.001 Benign Prostatic Hyperplasia NA BeFree Detail
<0.001 Enchondroma NA BeFree Detail
<0.001 Colorectal Mucinous Adenocarcinoma NA BeFree Detail
<0.001 Colorectal Signet Ring Cell Carcinoma NA BeFree Detail
<0.001 Invasive Skin Melanoma Biallelic inactivation of CDKN2A emerged exclusively in invasive melanomas. BeFree 26559571 Detail
0.004 Non-Neoplastic Disorder Polysomy 6 and p16 deletion were significantly more frequent in noninvasive than... BeFree 25517961 Detail
<0.001 Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type NA BeFree Detail
<0.001 Pyothorax-Associated Lymphoma NA BeFree Detail
0.002 Meningioma, benign, no ICD-O subtype Progression to a clinically aggressive meningioma is linked to inactivation of C... BeFree 25993161 Detail
0.003 Idiopathic Pulmonary Fibrosis NA BeFree,LHGDN Detail
0.361 Melanoma astrocytoma syndrome NA BeFree,CLINVAR,CTD_human,ORPHANET Detail
0.240 MELANOMA, CUTANEOUS MALIGNANT, 2 NA CTD_human,UNIPROT Detail
0.240 Li-Fraumeni syndrome 1 NA CTD_human,UNIPROT Detail
<0.001 SKIN/HAIR/EYE PIGMENTATION, VARIATION IN, 2 (disorder) NA BeFree Detail
0.080 Oculopalatocerebral Syndrome NA MGD Detail
<0.001 Familial primary gastric lymphoma NA BeFree Detail
<0.001 lateral meningocele syndrome NA BeFree Detail
<0.001 ulnar-mammary syndrome NA BeFree Detail
<0.001 Retinomas (translucent, grayish retinal mass protruding into the vitreous) NA BeFree Detail
<0.001 B-CELL MALIGNANCY, LOW-GRADE NA BeFree Detail
<0.001 biliary papillomatosis NA BeFree Detail
<0.001 Inverted Squamous Cell Papilloma NA BeFree Detail
0.002 uterine corpus cancer NA BeFree Detail
<0.001 Wolf-Hirschhorn syndrome NA BeFree Detail
0.012 coronary artery disease Using this approach, numerous studies have associated SNPs on chromosome 9p21.3 ... BeFree,GAD 25744911 Detail
0.009 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma NA BeFree,LHGDN Detail
0.275 Precursor Cell Lymphoblastic Leukemia Lymphoma Deletions of EBF1, IKZF1, and CDKN2A/B have an independent adverse prognosis for... BeFree,CTD_human,GAD,GWASCAT,LHGDN 26194343 Detail
<0.001 low grade glioma NA BeFree Detail
<0.001 Autosomal aneuploidy NA BeFree Detail
0.002 Urothelial Carcinoma To determine the potential association between HPV infection and the squamous ce... BeFree 24675970 Detail
<0.001 eyelids (symptom) Furthermore, p16 overexpression in eyelid SCs was also significantly higher than... BeFree 25468813 Detail
0.252 liver carcinoma Role of P14 and MGMT gene methylation in hepatocellular carcinomas: a meta-analy... BeFree,CTD_human,LHGDN,RGD 25169493 Detail
0.252 liver carcinoma Sirtuin 6 in turn abrogated the inducing effect of TGF-β1/H2O2/HOCl on cellular ... BeFree,CTD_human,LHGDN,RGD 25683165 Detail
0.252 liver carcinoma During the last 10 years, there has been a clear delineation of the landscape of... BeFree,CTD_human,LHGDN,RGD 26099527 Detail
0.003 Familial Atypical Mole Melanoma Syndrome The p16-Leiden founder mutation in the CDKN2A gene is the most common cause of F... BeFree 26111702 Detail
<0.001 Triple-negative breast carcinoma NA BeFree Detail
0.006 Oropharyngeal Carcinoma The majority of North American respondents in this survey systematically test fo... BeFree 25096827 Detail
0.006 Oropharyngeal Carcinoma Interestingly, the prognostic significance of p16 overexpression is different fr... BeFree 25339028 Detail
0.006 Oropharyngeal Carcinoma Among these biomarkers, p53 is the strongest prognostic marker in OPC and p53 in... BeFree 25380690 Detail
0.006 Oropharyngeal Carcinoma Significant correlations were confirmed between p16 positivity and oropharyngeal... BeFree 25503184 Detail
0.006 Oropharyngeal Carcinoma Overall, this study provides evidence of epigenetic changes to the downstream re... BeFree 25619363 Detail
0.006 Oropharyngeal Carcinoma Prognostic value of p16 expression irrespective of human papillomavirus status i... BeFree 26056326 Detail
0.006 Oropharyngeal Carcinoma Population-based p16 and HPV positivity rates in oropharyngeal cancer in Southea... BeFree 26152733 Detail
<0.001 Cerebral Small Vessel Diseases NA BeFree Detail
<0.001 Human Papillomavirus Positive Oropharyngeal Squamous Cell Carcinoma The results showed that the membrane weighted index of β-catenin was inversely c... BeFree 25209444 Detail
<0.001 Human Papillomavirus Positive Oropharyngeal Squamous Cell Carcinoma Epigenetic changes in the CDKN2A locus are associated with differential expressi... BeFree 25619363 Detail
<0.001 Chronic ulcerative colitis NA BeFree Detail
0.123 Pancreatic carcinoma, familial NA BeFree,ORPHANET Detail
<0.001 Atypical Hemolytic Uremic Syndrome Genomic aberrations affecting the genes encoding factor H (FH) and the five FH-r... BeFree 24904082 Detail
0.126 Nasopharyngeal carcinoma We here evaluated p16 INK4A as a prognostic marker of treatment response and sur... BeFree,CTD_human 25640361 Detail
<0.001 Cervix Intraepithelial Neoplasia Grade 3 AJCC v7 NA BeFree Detail
0.002 Solar Erythema NA GAD Detail
<0.001 Condylomatous carcinoma Diffuse p16 expression was associated with younger age at presentation (P<0.0001... BeFree 26171917 Detail
<0.001 Ischemic Cerebrovascular Accident NA BeFree Detail
<0.001 Biliary System Disorder NA BeFree Detail
0.003 myelodysplastic syndrome NA BeFree,GAD Detail
<0.001 plasmablastic lymphoma NA BeFree Detail
<0.001 Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor NA BeFree Detail
<0.001 Progressive cGVHD NA BeFree Detail
<0.001 Triple Negative Breast Neoplasms NA BeFree Detail
0.001 Melanocytic nevus of skin NA BeFree Detail
<0.001 Mammary adenocarcinoma NA BeFree Detail
<0.001 Proliferative verrucous oral leukoplakia NA BeFree Detail
0.014 Infection NA LHGDN Detail
0.120 Leukemia, acute lymphoblastic, susceptibility to, 3 NA ORPHANET Detail
0.003 Experimental Organism Basal Cell Carcinoma NA BeFree Detail
<0.001 High grade serous carcinoma Immunohistochemistry (IHC) was used to examine STMN1 and p16 expression in fallo... BeFree 26206555 Detail
<0.001 Cytogenetically normal acute myeloid leukemia NA BeFree Detail
0.180 adenocarcinoma Different roles for p16(INK) (4a) -Rb pathway and INK4a/ARF methylation between ... BeFree,CTD_human,GAD,LHGDN 25123601 Detail
0.021 adenoma NA BeFree,LHGDN Detail
0.120 Adrenal Gland Neoplasms NA CTD_human Detail
<0.001 Primary myelofibrosis NA BeFree Detail
0.003 Alzheimer's disease NA BeFree,GAD Detail
<0.001 ameloblastoma NA BeFree Detail
<0.001 amyotrophic lateral sclerosis NA BeFree Detail
0.001 Anaplasia NA BeFree Detail
<0.001 anemia NA BeFree Detail
0.002 Aneuploidy NA GAD Detail
<0.001 Anxiety Disorders NA BeFree Detail
<0.001 aortic aneurysm NA BeFree Detail
0.002 arteriosclerosis An increased CDKN2A gene expression in carotid plaques may increase the severity... BeFree 24599170 Detail
<0.001 arthritis NA BeFree Detail
<0.001 Arthritis, Adjuvant-Induced NA BeFree Detail
0.002 rheumatoid arthritis NA BeFree Detail
0.002 asthma NA GAD Detail
0.015 Astrocytoma Herein we showed that activation of CD47 in human astrocytoma cell lines U87 and... BeFree,LHGDN 25550546 Detail
0.015 Astrocytoma CDKN2A loss is associated with shortened overall survival in lower-grade (World ... BeFree,LHGDN 25853694 Detail
<0.001 ataxia telangiectasia NA BeFree Detail
0.004 atherosclerosis An increased CDKN2A gene expression in carotid plaques may increase the severity... BeFree,GAD 24599170 Detail
<0.001 Tooth Attrition NA BeFree Detail
<0.001 Autoimmune Diseases NA BeFree Detail
0.011 Barrett esophagus Barrett's esophagus is thought to progress to esophageal adenocarcinoma (EAC) th... BeFree,GAD,LHGDN 26192918 Detail
<0.001 Behcet Syndrome NA BeFree Detail
0.002 Bile Duct Neoplasms NA GAD Detail
0.022 Malignant neoplasm of urinary bladder Detection of human papillomavirus infection and p16 immunohistochemistry express... BeFree,GAD 24675970 Detail
0.022 Malignant neoplasm of urinary bladder Transfection of the DNAzyme caused significant down-regulation of DNMT1 expressi... BeFree,GAD 25888794 Detail
0.145 Bladder Neoplasm NA BeFree,CTD_human,LHGDN Detail
0.002 Blast Phase NA BeFree Detail
0.136 Brain Neoplasms NA BeFree,CTD_human,GAD Detail
<0.001 Branchioma However, cases of ambiguous p16(INK4a) overexpression are regularly detected in ... BeFree 25104331 Detail
0.043 Malignant neoplasm of breast In a cross-sectional study of 138 women with no history of breast cancer who und... BeFree,GAD 25344837 Detail
<0.001 Brenner Tumor NA BeFree Detail
0.002 Burkitt lymphoma Quantitative analysis of CDKN2A methylation, mRNA, and p16(INK4a) protein expres... BeFree 25542698 Detail
0.002 calcinosis NA GAD Detail
<0.001 Carcinoid Tumor NA BeFree Detail
0.005 Malignant tumor of colon Molecular subtypes in stage II-III colon cancer defined by genomic instability: ... BeFree 25879218 Detail
0.002 Malignant neoplasm of endometrium NA BeFree Detail
<0.001 female breast carcinoma NA BeFree Detail
<0.001 Malignant neoplasm of larynx NA BeFree Detail
<0.001 Rectal Carcinoma NA BeFree Detail
0.002 Malignant neoplasm of skin Vitamin C protects against UV irradiation-induced apoptosis through reactivating... BeFree 25003799 Detail
0.002 Malignant neoplasm of skin CDKN2a mutation-negative melanoma families have increased risk exclusively for s... BeFree 25943250 Detail
0.002 Malignant neoplasm of thyroid NA BeFree Detail
0.008 basal cell carcinoma NA GAD,LHGDN Detail
0.001 Noninfiltrating Intraductal Carcinoma NA BeFree Detail
0.001 Merkel cell carcinoma NA BeFree Detail
<0.001 mucinous adenocarcinoma NA BeFree Detail
0.150 Non-small cell lung carcinoma Assessment of the prognostic value of methylation status and expression levels o... BeFree,CTD_human,GAD 24935385 Detail
0.150 Non-small cell lung carcinoma Methylation of APC and/or p16 was related to advanced staging in non-small cell ... BeFree,CTD_human,GAD 26119430 Detail
0.004 Carcinoma, Papillary NA BeFree,LHGDN Detail
0.014 renal cell carcinoma NA BeFree,LHGDN Detail
Annotation

Annotations

DescrptionSourceLinks
In a phase 2 trial, patients with pancreatic cancer with CDKN2A loss or mutation were received palbo... CIViC Evidence Detail
In a phase 2 trial, patients with gallbladder cancer or bile duct cancer with CDKN2A loss or mutatio... CIViC Evidence Detail
The p14 promoter was unmethylated in 86.7 % of OSCC and in 85.7 % of LSCC patients; for the p16 prom... DisGeNET Detail
The correlation between p16 expression and INK4a locus mutation with grades and stages in oral squam... DisGeNET Detail
HPV infection appears to be involved in cancer progression in SQC by promoting the expression of p53... DisGeNET Detail
p16INK4A expression in squamous cell carcinomas of the vagina and the vulva in Tunisian women. DisGeNET Detail
Development of squamous cell cancer of head and neck (SCCHN) is associated with human papillomavirus... DisGeNET Detail
Human papillomavirus (HPV), p16 expression, and TP53 mutations are known prognostic factors in head ... DisGeNET Detail
These findings utilize morphologic and immunohistochemical analysis to support HPV-associated and HP... DisGeNET Detail
To determine the potential association between HPV infection and the squamous cell component of urot... DisGeNET Detail
NA DisGeNET Detail
Transcriptome analysis of mouse and human DCM samples indicates that p16(INK4a) derepression, accomp... DisGeNET Detail
NA DisGeNET Detail
A dense infiltrate of IL-6(+) mononuclear cells was detected in active coeliac disease, also localis... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
Medline, Embase and China National Knowledge Infrastructures were searched to identify studies on th... DisGeNET Detail
Methylation of the p16(INK4a) gene occurs early in the development of cervical cancer. DisGeNET Detail
p16INK4A expression could be used as a useful marker for HPV positivity in vaginal SCCs similar to t... DisGeNET Detail
Moreover, p16 protein was associated with CIN grade and lymph node metastases in cervical cancer (al... DisGeNET Detail
NA DisGeNET Detail
Immunohistochemistry of p16INK4A staining shows nil (0/25) expression in the cervicitis patients, 72... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
In contrast, the expression of p16INK4a was seen in most bile duct adenomas and all ductular reactio... DisGeNET Detail
NA DisGeNET Detail
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We show that p16/CDKN2A copy number variation occurs subsequent to the IDH1 mutation, and confirm th... DisGeNET Detail
Genotyping cancer-associated genes in chordoma identifies mutations in oncogenes and areas of chromo... DisGeNET Detail
NA DisGeNET Detail
Progression from ulcerative colitis (UC) toward colorectal carcinoma (CRC) is multistep process that... DisGeNET Detail
NA DisGeNET Detail
Investigation of IL-23 (p19, p40) and IL-23R identifies nuclear expression of IL-23 p19 as a favorab... DisGeNET Detail
Progression from ulcerative colitis (UC) toward colorectal carcinoma (CRC) is multistep process that... DisGeNET Detail
Combined methylation of p16 and hMLH1 (CMETH2) discriminates a subpopulation with better prognosis i... DisGeNET Detail
An adenoviral construct of the human p14ARF gene (a tumor suppressor) and a 22 amino acid sequence o... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
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We review the current knowledge, from studies using human and mouse models, describing the function ... DisGeNET Detail
We review the current knowledge, from studies using human and mouse models, describing the function ... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
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Therefore, we hypothesized that the genetic variants in these three genes influence the predispositi... DisGeNET Detail
Therefore, we hypothesized that the genetic variants in these three genes influence the predispositi... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
Thus, p16 hypermethylation may aid as a biomarker in identifying habitués at greater risk for esopha... DisGeNET Detail
NA DisGeNET Detail
Polysomy 6 and p16 deletion were significantly more frequent in noninvasive than in non-neoplastic s... DisGeNET Detail
Furthermore, p16 overexpression in eyelid SCs was also significantly higher than that in other eyeli... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
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Deletions of RDINK4/ARF enhancer in gastrinomas and nonfunctioning pancreatic neuroendocrine tumors. DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
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Finally, the G-CIMP+ Ink4a-Arf-/- EGFRvIII glioblastoma line was more resistant to the EGFR inhibito... DisGeNET Detail
CD47 activation-induced UHRF1 over-expression is associated with silencing of tumor suppressor gene ... DisGeNET Detail
Bmi-1 regulates the migration and invasion of glioma cells through p16. DisGeNET Detail
BRAF mutation and CDKN2A deletion define a clinically distinct subgroup of childhood secondary high-... DisGeNET Detail
These findings suggest that CDKN2A testing may provide further clinical aid in lower-grade glioma su... DisGeNET Detail
CDKN2A (p16) mRNA decreased expression is a marker of poor prognosis in malignant high-grade glioma. DisGeNET Detail
These findings show that CDKN2 p16 540 C>G, CDKN2 p16 580 C>T and MDM2 SNP309 T>G variants and their... DisGeNET Detail
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ECCCs had SCA-like features with rare expression of estrogen receptor/progesterone receptor (18.8%/6... DisGeNET Detail
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Interestingly, all the aggressive cases did not express p16(INK4a), thus suggesting that loss of sen... DisGeNET Detail
Peptides (9mer to 11mer) were designed based on HLA-I-binding algorithms for B*27, B*57, or B*5801 (... DisGeNET Detail
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Deletions of EBF1, IKZF1, and CDKN2A/B have an independent adverse prognosis for adolescents and adu... DisGeNET Detail
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Cell-cycle regulation was affected by aberrant methylation of CDKN2A and CHFR in 13 GCs. DisGeNET Detail
The present results indicated that the methylation of p16, CDH1, MGMT, and hMLH1 was both frequent a... DisGeNET Detail
The relationship between P16 gene promoter methylation and gastric cancer: a meta-analysis based on ... DisGeNET Detail
ANRIL, a lncRNA co-clustered mainly with p14/ARF has been reported to be dysregulated in gastric can... DisGeNET Detail
Moreover, their combined treatment synergistically arrested GC cells at G0/G1 phase, down-regulated ... DisGeNET Detail
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Progression to a clinically aggressive meningioma is linked to inactivation of CDKN2A/B genes, and a... DisGeNET Detail
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Functional genomics of the CDKN2A/B locus in cardiovascular and metabolic disease: what have we lear... DisGeNET Detail
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The cyclin-dependent kinase inhibitor 1 (CDKN2B or p15(INK4B) ) gene lies adjacent to the tumor supp... DisGeNET Detail
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As p16 (CDKN2A), a marker of HPV infections, was up-regulated in MG-T, we thus screened DNA from thy... DisGeNET Detail
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Dysregulation of the MIRLET7/HMGA2 axis with methylation of the CDKN2A promoter in myeloproliferativ... DisGeNET Detail
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Alcohol consumption, location, and features of neck metastasis were correlated with p16 expression. DisGeNET Detail
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After adjustment for IDH mutation, sex, and age, CDKN2A deletion was strongly associated with poorer... DisGeNET Detail
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Further, we could deduce genes with possible prognostic significance in OS for further investigation... DisGeNET Detail
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None of the cell lines showed strong immunopositivity of p16 or presence of human papilloma virus. DisGeNET Detail
Immunohistochemical staining provided diagnostic results for all of the examined tissue samples, and... DisGeNET Detail
Human papilloma virus early proteins E6 (HPV16/18-E6) and the cell cycle marker P16 (INK4a) are usef... DisGeNET Detail
Another significant finding was a very poor concordance between p16 expression and HPV infection sug... DisGeNET Detail
Positivity for HPV DNA (44 samples, 18.9 %) and p16(INK4A) expression (102 samples, 43.8 %) were sig... DisGeNET Detail
Formalin-fixed, paraffin-embedded material from each case was evaluated for p16 expression using imm... DisGeNET Detail
FGFR1, -2, and -4, VEGFR2, PDGFRα, and p16 were overexpressed in primary human pheochromocytomas and... DisGeNET Detail
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FGFR1, -2, and -4, VEGFR2, PDGFRα, and p16 were overexpressed in primary human pheochromocytomas and... DisGeNET Detail
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In the present study, the diagnostic utility of the SHOX2 assay was tested with regard to cytology f... DisGeNET Detail
The aim of this study was to investigate promoter methylation of certain tumor suppressor genes, Cyc... DisGeNET Detail
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Sequence analysis demonstrated a known deleterious mutation in CDKN2A (G-34T) and homozygosity for a... DisGeNET Detail
The prime aim of this study was to evaluate the mismatch-repair (MMR)-protein deficiency and the p16... DisGeNET Detail
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The aim was to explore putative differences in p16(INK) (4a) -retinoblastoma (Rb) pathway and INK4a/... DisGeNET Detail
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The prime aim of this study was to evaluate the mismatch-repair (MMR)-protein deficiency and the p16... DisGeNET Detail
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As p16 (CDKN2A), a marker of HPV infections, was up-regulated in MG-T, we thus screened DNA from thy... DisGeNET Detail
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Our findings demonstrate that while deletions on chromosomes 4 and 11 affecting Cdkn2a and Ikaros ar... DisGeNET Detail
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p19ARF is a critical mediator of both cellular senescence and an innate immune response associated w... DisGeNET Detail
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Correlation between squamous cell carcinoma of the lung and human papillomavirus infection and the r... DisGeNET Detail
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This is the first estimate of the contribution of BAP1 and CDK4 to a population-based sample of CMM ... DisGeNET Detail
To conclude, we propose that mutation screening of CDKN2A and CDK4 in Denmark should predominantly b... DisGeNET Detail
Two-hit inactivation of CDKN2A and CDKN2B occurs frequently in patients with mutant KRAS lung adenoc... DisGeNET Detail
Thus, p16 hypermethylation may aid as a biomarker in identifying habitués at greater risk for esopha... DisGeNET Detail
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Risk stratification of early stage oral tongue cancers based on HPV status and p16 immunoexpression. DisGeNET Detail
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The majority of North American respondents in this survey systematically test for HPV-DNA and/or p16... DisGeNET Detail
Interestingly, the prognostic significance of p16 overexpression is different from that reported in ... DisGeNET Detail
Among these biomarkers, p53 is the strongest prognostic marker in OPC and p53 in addition to p16 sup... DisGeNET Detail
Significant correlations were confirmed between p16 positivity and oropharyngeal cancer, MMP1 and p1... DisGeNET Detail
Overall, this study provides evidence of epigenetic changes to the downstream region of the CDKN2A l... DisGeNET Detail
Population-based p16 and HPV positivity rates in oropharyngeal cancer in Southeast Scotland. DisGeNET Detail
We here evaluated p16 INK4A as a prognostic marker of treatment response and survival in our SCCHN p... DisGeNET Detail
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We evaluated combined HPV DNA and p16 status as a prognostic factor of treatment response in anal ca... DisGeNET Detail
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Thus, patients with P16(ink4a) negative penile cancer, particularly those with lymph node metastases... DisGeNET Detail
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HPV infection appears to be involved in cancer progression in SQC by promoting the expression of p53... DisGeNET Detail
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Copy number analyses by molecular inversion probe assays of the three spindle cell carcinoma samples... DisGeNET Detail
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The p16-Leiden founder mutation in the CDKN2A gene is the most common cause of Familial Atypical Mul... DisGeNET Detail
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Nevertheless, p16 overexpression was found in 71.4% (10/14) of SCs, irrespective of the status of HP... DisGeNET Detail
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ECCCs had SCA-like features with rare expression of estrogen receptor/progesterone receptor (18.8%/6... DisGeNET Detail
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Exome and the following prevalence sequencing identified mutations of the BAP1, ARID1A, IDH1 and IDH... DisGeNET Detail
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β-PV DNA was detected in 5/30 VC (16.7%) and in 18/30 normal tissue samples (60.0%): HPV-19, -24 and... DisGeNET Detail
Diffuse p16 expression was associated with younger age at presentation (P<0.0001), basaloid and wart... DisGeNET Detail
In this study, high-risk HPV E6/E7 and p16 mRNA expression patterns in eighty-six CIN lesions were i... DisGeNET Detail
We also used immunohistochemistry (IHC) to detect the P16(INK4a) protein, the expression of which is... DisGeNET Detail
Immunohistochemistry of p16INK4A staining shows nil (0/25) expression in the cervicitis patients, 72... DisGeNET Detail
P16INK4A and survivin: Diagnostic and prognostic markers in cervical intraepithelial neoplasia and c... DisGeNET Detail
PanHPVE4 and p16INK4a staining are complementary markers that could provide simple, reliable support... DisGeNET Detail
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Epigenetic regulation of p14ARF and p16INK4A expression in cutaneous and uveal melanoma. DisGeNET Detail
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CDKN2A/B deletions were associated with multiple MBMs and frequently hypermethylated genes with shor... DisGeNET Detail
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Increasing knowledge about the molecular pathogenesis of the disease has shown that genetic alterati... DisGeNET Detail
Our results strongly support that the deletion of RD may represent a novel mechanism to simultaneous... DisGeNET Detail
Our results show that the clinical candidate AKT inhibitor MK-2206 promotes ARF nucleolar localizati... DisGeNET Detail
Studies of the molecular pathology of pancreatic cancer have revealed that activation of KRAS, overe... DisGeNET Detail
The p16-Leiden germline variant in the CDKN2A gene is associated with a high risk of melanoma and pa... DisGeNET Detail
This review presents current evidence regarding both senescence induction and escape with respect to... DisGeNET Detail
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We here evaluated p16 INK4A as a prognostic marker of treatment response and survival in our SCCHN p... DisGeNET Detail
Lack of P16ink4a over expression in penile squamous cell carcinoma is associated with recurrence aft... DisGeNET Detail
HR-HPV(+) PSCCs overexpressed p16(INK4a) in 88% cases and p53 in 35% of cases, whereas HR-HPV(-) PSC... DisGeNET Detail
The role of histologic subtype, p16(INK4a) expression, and presence of human papillomavirus DNA in p... DisGeNET Detail
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Furthermore, comparative analysis of mutant Kras;Cdkn2a null with Kras;Cdkn2ab null mice and experim... DisGeNET Detail
A cross-sectional study was conducted in which the methylation status of DAPK, CDKN2A (p16) and RASS... DisGeNET Detail
In the present study, the diagnostic utility of the SHOX2 assay was tested with regard to cytology f... DisGeNET Detail
ANRIL, a lncRNA co-clustered mainly with p14/ARF has been reported to be dysregulated in gastric can... DisGeNET Detail
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BRAF mutation and CDKN2A loss occurred early and TERT promoter mutation later in a case of lethal me... DisGeNET Detail
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Frequency of genetic and epigenetic alterations of p14ARF and p16INK4A in head and neck cancer in a ... DisGeNET Detail
Combination of p16(INK4a) /Ki67 immunocytology and HPV polymerase chain reaction for the noninvasive... DisGeNET Detail
P16(INK4A) expression and HGAOT are independent prognostic factors for OS of patients with HNSCC, wh... DisGeNET Detail
HPV-associated p16 INK4A expression and response to therapy and survival in selected head and neck c... DisGeNET Detail
p16INK4a Status and Response to Induction Low-Dose Fractionated Radiation in Advanced Head and Neck ... DisGeNET Detail
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The results of this study suggested that MDM2 and p16 are predictive markers for chemoradioresistanc... DisGeNET Detail
Reanalysis of additional EAC exome data showed that the majority (62.5%) of EACs emerged following g... DisGeNET Detail
We evaluated combined HPV DNA and p16 status as a prognostic factor of treatment response in anal ca... DisGeNET Detail
These results indicate that p16, p63 and p53 can be used as prognostic markers in gallbladder adenoc... DisGeNET Detail
P16INK4A and survivin: Diagnostic and prognostic markers in cervical intraepithelial neoplasia and c... DisGeNET Detail
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The expression patterns of p53 and p16 and an analysis of a possible role of HPV in primary adenocar... DisGeNET Detail
Changes in PTEN and CDKN2A gene sets were associated with worsened prognosis of ccRCC. DisGeNET Detail
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The combination of both HPV-DNA sequencing analysis and immunohistochemistry (IHC) for p16(INK4A) is... DisGeNET Detail
We assessed a population-based cohort of patients diagnosed with oropharyngeal squamous cell carcino... DisGeNET Detail
The authors explored the prognostic significance of heregulin/HER3 expression in patients with oroph... DisGeNET Detail
We applied HPV DNA PCR and p16 immunohistochemistry to all TSCCs registered in the Danish Head and N... DisGeNET Detail
P16(INK⁴a) overexpression is associated with CDKN2A mutation and worse prognosis in HPV-negative lar... DisGeNET Detail
Frequency and prognostic significance of p16(INK4A) protein overexpression and transcriptionally act... DisGeNET Detail
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After adjustment for IDH mutation, sex, and age, CDKN2A deletion was strongly associated with poorer... DisGeNET Detail
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p16INK4A expression could be used as a useful marker for HPV positivity in vaginal SCCs similar to t... DisGeNET Detail
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Human papilloma virus early proteins E6 (HPV16/18-E6) and the cell cycle marker P16 (INK4a) are usef... DisGeNET Detail
Immunohistochemistry of p16INK4A staining shows nil (0/25) expression in the cervicitis patients, 72... DisGeNET Detail
Medline, Embase and China National Knowledge Infrastructures were searched to identify studies on th... DisGeNET Detail
Methylation of the p16(INK4a) gene occurs early in the development of cervical cancer. DisGeNET Detail
p16INK4A expression could be used as a useful marker for HPV positivity in vaginal SCCs similar to t... DisGeNET Detail
Moreover, p16 protein was associated with CIN grade and lymph node metastases in cervical cancer (al... DisGeNET Detail
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The combination TOP2A and CDKN2A/p16 has a good balance between sensitivity and specificity for the ... DisGeNET Detail
A marker with high sensitivity and specificity for the detection of HSIL in cervical, vulvar, and an... DisGeNET Detail
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Compared with CDKN2A(-) cases, mutation carriers tended to have histologic features of superficial s... DisGeNET Detail
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Within the 1p/19q-codeleted AO, the contrast enhancement was associated with larger tumor volumes (P... DisGeNET Detail
After adjustment for IDH mutation, sex, and age, CDKN2A deletion was strongly associated with poorer... DisGeNET Detail
High-dose cytarabine does not overcome the adverse prognostic value of CDKN2A and TP53 deletions in ... DisGeNET Detail
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Evaluation of genetic association of the INK4 locus with primary open angle glaucoma in East Indian ... DisGeNET Detail
The severity of internal carotid artery stenosis is associated with the cyclin-dependent kinase inhi... DisGeNET Detail
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Detection of human papillomavirus infection and p16 immunohistochemistry expression in bladder cance... DisGeNET Detail
Correlation between squamous cell carcinoma of the lung and human papillomavirus infection and the r... DisGeNET Detail
Frequency and prognostic significance of p16(INK4A) protein overexpression and transcriptionally act... DisGeNET Detail
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Given overexpression of a polycomb group protein EZH2 in intrahepatic cholangiocarcinoma and high ex... DisGeNET Detail
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Diffuse p16 expression was associated with younger age at presentation (P<0.0001), basaloid and wart... DisGeNET Detail
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Increasing knowledge about the molecular pathogenesis of the disease has shown that genetic alterati... DisGeNET Detail
Our results strongly support that the deletion of RD may represent a novel mechanism to simultaneous... DisGeNET Detail
Our results show that the clinical candidate AKT inhibitor MK-2206 promotes ARF nucleolar localizati... DisGeNET Detail
Studies of the molecular pathology of pancreatic cancer have revealed that activation of KRAS, overe... DisGeNET Detail
The p16-Leiden germline variant in the CDKN2A gene is associated with a high risk of melanoma and pa... DisGeNET Detail
This review presents current evidence regarding both senescence induction and escape with respect to... DisGeNET Detail
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Stathmin 1 and p16(INK4A) are sensitive adjunct biomarkers for serous tubal intraepithelial carcinom... DisGeNET Detail
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Compared with high-risk HPV genotyping, p16(INK4a)/Ki-67 immunocytochemistry was a more accurate tri... DisGeNET Detail
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By contrast, p16 negatively, but not HPV 16 genotype, is an independent adverse prognosticator after... DisGeNET Detail
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To combine clinical and molecular markers into an algorithm for predicting outcome for individual pa... DisGeNET Detail
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Association of p16 gene methylation with prostate cancer risk: a meta-analysis. DisGeNET Detail
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An assessment of the CDKN2A variant Ala148Thr as a nevus/melanoma susceptibility allele. DisGeNET Detail
An assessment of the CDKN2A variant Ala148Thr as a nevus/melanoma susceptibility allele. DisGeNET Detail
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The CDKN2A p.A148T variant is associated with cutaneous melanoma in Southern Brazil. DisGeNET Detail
The CDKN2A p.A148T variant is associated with cutaneous melanoma in Southern Brazil. DisGeNET Detail
An assessment of the CDKN2A variant Ala148Thr as a nevus/melanoma susceptibility allele. DisGeNET Detail
In the total set of 189 patients we found a novel change Pro48Arg (nt 143 c &gt; g), a novel introni... DisGeNET Detail
An assessment of the CDKN2A variant Ala148Thr as a nevus/melanoma susceptibility allele. DisGeNET Detail
An assessment of the CDKN2A variant Ala148Thr as a nevus/melanoma susceptibility allele. DisGeNET Detail
The CDKN2A A148T variant seems to contribute to early-onset breast cancer in Poland. DisGeNET Detail
The CDKN2a common variants: 148 Ala/Thr and 500 C/G in 3' UTR, and their association with clinical c... DisGeNET Detail
In the total set of 189 patients we found a novel change Pro48Arg (nt 143 c &gt; g), a novel introni... DisGeNET Detail
In the total set of 189 patients we found a novel change Pro48Arg (nt 143 c &gt; g), a novel introni... DisGeNET Detail
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Aberrant promoter hypermethylation of p16 gene in endometrial carcinoma. DisGeNET Detail
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Thus, p16 hypermethylation may aid as a biomarker in identifying habitués at greater risk for esopha... DisGeNET Detail
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In total, 24% of the HNSCCUP patients were p16 positive. p16 overexpression in neck metastasis was p... DisGeNET Detail
No association between KRAS-variant status and p16 expression was observed in the oropharynx subset ... DisGeNET Detail
Among those HNSCCs that were positive for HR-HPV, 18 (100%) of 18 originated from the oropharynx, wh... DisGeNET Detail
HPV E7 seropositivity correlated with positive tumor HPV-DNA and p16 expression, and was strongly as... DisGeNET Detail
Strikingly, STAG2 mutations and CDKN2A deletions were mutually exclusive, as confirmed in Ewing sarc... DisGeNET Detail
A growing collection of retrospective studies have suggested that TP53 mutations and/or CDKN2A delet... DisGeNET Detail
MiR-34a tumor levels significantly correlated with oropharyngeal origin (p=0.0284) and p16 positivit... DisGeNET Detail
Immunohistochemistry for p16 protein is often used as a surrogate marker for oncogenic HPV in the or... DisGeNET Detail
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Risk stratification of early stage oral tongue cancers based on HPV status and p16 immunoexpression. DisGeNET Detail
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In addition, the p16(INK4a) expression is associated with carotid atherosclerosis in various patient... DisGeNET Detail
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Further, we could deduce genes with possible prognostic significance in OS for further investigation... DisGeNET Detail
The role of p19 and p21 H-Ras proteins and mutants in miRNA expression in cancer and a Costello synd... DisGeNET Detail
Our data indicate that SIX6 and/or IOP promotes POAG by directly increasing p16INK4a expression, lea... DisGeNET Detail
To verify the S305N association with melanoma risk in an independent larger French population (378 p... DisGeNET Detail
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To verify the S305N association with melanoma risk in an independent larger French population (378 p... DisGeNET Detail
To verify the S305N association with melanoma risk in an independent larger French population (378 p... DisGeNET Detail
These results indicate that RD deletion and BMI1 overexpression frequently occur in the early stage ... DisGeNET Detail
Slug regulates E-cadherin repression via p19Arf in prostate tumorigenesis. DisGeNET Detail
Cooperativity of oncogenic K-ras and downregulated p16/INK4A in human pancreatic tumorigenesis. DisGeNET Detail
Deletion of Ptprd and Cdkn2a cooperate to accelerate tumorigenesis. DisGeNET Detail
p16(INK4a) is a tumor suppressor gene, frequently hypermethylated in breast cancer; this epigenetic ... DisGeNET Detail
There is a need for identification of biomarkers to identify people at risk of esophageal cancer. p1... DisGeNET Detail
The aim of this study was to investigate promoter methylation of certain tumor suppressor genes, Cyc... DisGeNET Detail
We hypothesize that the presence of the fourth product, pALT(INK4a/b) of the INK4a/b locus in the na... DisGeNET Detail
We have shown that an epigenetic diet can influence both cellular longevity and carcinogenesis throu... DisGeNET Detail
Regarding the oncogenesis of primary brain tumors, it was shown that changes in functions of p16 and... DisGeNET Detail
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Association of increased levels of TGF-β1 and p14ARF in prostate carcinoma cell lines overexpressing... DisGeNET Detail
Association of p16 gene methylation with prostate cancer risk: a meta-analysis. DisGeNET Detail
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However, our data support the presence of 2 different mechanisms for p16INK4A expression in HPV-rela... DisGeNET Detail
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p16/CDKN2A FISH in Differentiation of Diffuse Malignant Peritoneal Mesothelioma From Mesothelial Hyp... DisGeNET Detail
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Six genes were differentially expressed in patients with localized and locally advanced cancer (GOLM... DisGeNET Detail
In a cross-sectional study of 138 women with no history of breast cancer who underwent reduction mam... DisGeNET Detail
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Furthermore, comparative analysis of mutant Kras;Cdkn2a null with Kras;Cdkn2ab null mice and experim... DisGeNET Detail
A cross-sectional study was conducted in which the methylation status of DAPK, CDKN2A (p16) and RASS... DisGeNET Detail
In the present study, the diagnostic utility of the SHOX2 assay was tested with regard to cytology f... DisGeNET Detail
ANRIL, a lncRNA co-clustered mainly with p14/ARF has been reported to be dysregulated in gastric can... DisGeNET Detail
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Patients with a lower alcohol consumption, only level II/III metastasis, and cystic lymph node metas... DisGeNET Detail
The results showed that the membrane weighted index of β-catenin was inversely correlated with p16 p... DisGeNET Detail
Thus, patients with P16(ink4a) negative penile cancer, particularly those with lymph node metastases... DisGeNET Detail
Moreover, p16 protein was associated with CIN grade and lymph node metastases in cervical cancer (al... DisGeNET Detail
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Molecular subtypes in stage II-III colon cancer defined by genomic instability: early recurrence-ris... DisGeNET Detail
Cell-cycle regulation was affected by aberrant methylation of CDKN2A and CHFR in 13 GCs. DisGeNET Detail
The present results indicated that the methylation of p16, CDH1, MGMT, and hMLH1 was both frequent a... DisGeNET Detail
The relationship between P16 gene promoter methylation and gastric cancer: a meta-analysis based on ... DisGeNET Detail
ANRIL, a lncRNA co-clustered mainly with p14/ARF has been reported to be dysregulated in gastric can... DisGeNET Detail
Moreover, their combined treatment synergistically arrested GC cells at G0/G1 phase, down-regulated ... DisGeNET Detail
Detection of human papillomavirus infection and p16 immunohistochemistry expression in bladder cance... DisGeNET Detail
Transfection of the DNAzyme caused significant down-regulation of DNMT1 expression and reactivation ... DisGeNET Detail
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Prognostic Relevance of HPV Infection and p16 Overexpression in Squamous Cell Anal Cancer. DisGeNET Detail
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Distribution and Effects of CDKN2 p16 540 C>G and 580 C>T, and MDM2 SNP309 T>G Polymorphisms in Pati... DisGeNET Detail
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After adjustment for IDH mutation, sex, and age, CDKN2A deletion was strongly associated with poorer... DisGeNET Detail
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The p16(INK4A)/pRb pathway and telomerase activity define a subgroup of Ph+ adult Acute Lymphoblasti... DisGeNET Detail
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The p14 promoter was unmethylated in 86.7 % of OSCC and in 85.7 % of LSCC patients; for the p16 prom... DisGeNET Detail
Development of squamous cell cancer of head and neck (SCCHN) is associated with human papillomavirus... DisGeNET Detail
Genetic inactivation of PRC2 components, NF1, and CDKN2A are frequently detected in MPNSTs. DisGeNET Detail
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MDM2 is an important prognostic and predictive factor for platin-pemetrexed therapy in malignant ple... DisGeNET Detail
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Polysomy 6 and p16 deletion were significantly more frequent in noninvasive than in non-neoplastic s... DisGeNET Detail
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Thus, patients with P16(ink4a) negative penile cancer, particularly those with lymph node metastases... DisGeNET Detail
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Tumoral TP53 and/or CDKN2A alterations are not reliable prognostic biomarkers in patients with local... DisGeNET Detail
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Alterations in RD(INK4/ARF) -mediated en bloc regulation of the INK4-ARF locus in human squamous cel... DisGeNET Detail
KRAS-variant genotyping was conducted for these samples and 8 HNSCC cell lines. p16 expression was d... DisGeNET Detail
North-American survey on HPV-DNA and p16 testing for head and neck squamous cell carcinoma. DisGeNET Detail
All HPV oncogene-expressing HNSCC showed p16(INK4a) /Ki-67 co-expression. DisGeNET Detail
In conclusion, the data emphasize the urge for further data on HPV-infection in HNSCC to, e.g. clari... DisGeNET Detail
A simultaneous immunocytochemical detection of p16(INK4a) and Ki67 can reliably be performed on liqu... DisGeNET Detail
High-grade acute organ toxicity and p16(INK4A) expression as positive prognostic factors in primary ... DisGeNET Detail
To evaluate the impact of p16INK4a (p16) expression on clinical efficacy of induction low-dose fract... DisGeNET Detail
Human papillomavirus (HPV), p16 expression, and TP53 mutations are known prognostic factors in head ... DisGeNET Detail
Among those HNSCCs that were positive for HR-HPV, 18 (100%) of 18 originated from the oropharynx, wh... DisGeNET Detail
These results suggest that UGT2B17-deletion interacting with p16 (+) may modify effects of smoking o... DisGeNET Detail
Human papillomavirus E7 serology and association with p16 immunohistochemistry in squamous cell carc... DisGeNET Detail
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However, CDKN2A (encoding the p16 protein) is silenced nearly exclusively in the advanced areas of t... DisGeNET Detail
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These accumulations were associated with decreased levels of Cyclin A1, B1, and E1, and increased ex... DisGeNET Detail
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Dysregulation of the MIRLET7/HMGA2 axis with methylation of the CDKN2A promoter in myeloproliferativ... DisGeNET Detail
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Cdkn2a loss is associated with mTORC2 and Akt activation in human and murine melanocytic neoplasms. DisGeNET Detail
Performance of p16INK4a/Ki-67 immunocytochemistry for identifying CIN2+ in atypical squamous cells o... DisGeNET Detail
HPV DNA genotyping and methylation of gene p16 INK4A in cervical LSIL. DisGeNET Detail
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In specific PC populations, including in Italy, hereditary cancer predisposition genes such as CDKN2... DisGeNET Detail
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Copy number and loss of heterogeneity (LOH) profiles were similar in all six carcinomas; however, th... DisGeNET Detail
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Loss of the CDK4/6 inhibitor CDKN2A is a signature genetic event in PDA. DisGeNET Detail
Isocitrate dehydrogenase 1 mutations (IDH1) and p16/CDKN2A copy number change in conventional chondr... DisGeNET Detail
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Deletions of RDINK4/ARF enhancer in gastrinomas and nonfunctioning pancreatic neuroendocrine tumors. DisGeNET Detail
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In total, 24% of the HNSCCUP patients were p16 positive. p16 overexpression in neck metastasis was p... DisGeNET Detail
Germline CDKN2A mutations affecting p16(INK4a) were detected in 8 unrelated probands (13.6 %), inclu... DisGeNET Detail
By contrast, p16 negatively, but not HPV 16 genotype, is an independent adverse prognosticator after... DisGeNET Detail
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Germline mutations in the tumour suppressor gene CDKN2A occur in 5-20% of familial melanoma cases. DisGeNET Detail
Germline CDKN2A mutations in Brazilian patients of hereditary cutaneous melanoma. DisGeNET Detail
Genetics of familial melanoma: 20 years after CDKN2A. DisGeNET Detail
Familial melanomas with CDKN2A mutations preferentially express a histologic phenotype of dense pigm... DisGeNET Detail
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A borderline between cholangiolocellular carcinoma and the surrounding ductular reaction was clearly... DisGeNET Detail
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Our results show that the clinical candidate AKT inhibitor MK-2206 promotes ARF nucleolar localizati... DisGeNET Detail
Investigation of IL-23 (p19, p40) and IL-23R identifies nuclear expression of IL-23 p19 as a favorab... DisGeNET Detail
Combined methylation of p16 and hMLH1 (CMETH2) discriminates a subpopulation with better prognosis i... DisGeNET Detail
An adenoviral construct of the human p14ARF gene (a tumor suppressor) and a 22 amino acid sequence o... DisGeNET Detail
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ECCCs had SCA-like features with rare expression of estrogen receptor/progesterone receptor (18.8%/6... DisGeNET Detail
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Biallelic inactivation of CDKN2A emerged exclusively in invasive melanomas. DisGeNET Detail
Polysomy 6 and p16 deletion were significantly more frequent in noninvasive than in non-neoplastic s... DisGeNET Detail
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Progression to a clinically aggressive meningioma is linked to inactivation of CDKN2A/B genes, and a... DisGeNET Detail
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Using this approach, numerous studies have associated SNPs on chromosome 9p21.3 situated near the cy... DisGeNET Detail
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Deletions of EBF1, IKZF1, and CDKN2A/B have an independent adverse prognosis for adolescents and adu... DisGeNET Detail
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To determine the potential association between HPV infection and the squamous cell component of urot... DisGeNET Detail
Furthermore, p16 overexpression in eyelid SCs was also significantly higher than that in other eyeli... DisGeNET Detail
Role of P14 and MGMT gene methylation in hepatocellular carcinomas: a meta-analysis. DisGeNET Detail
Sirtuin 6 in turn abrogated the inducing effect of TGF-β1/H2O2/HOCl on cellular senescence of HCC ce... DisGeNET Detail
During the last 10 years, there has been a clear delineation of the landscape of genetic alterations... DisGeNET Detail
The p16-Leiden founder mutation in the CDKN2A gene is the most common cause of Familial Atypical Mul... DisGeNET Detail
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The majority of North American respondents in this survey systematically test for HPV-DNA and/or p16... DisGeNET Detail
Interestingly, the prognostic significance of p16 overexpression is different from that reported in ... DisGeNET Detail
Among these biomarkers, p53 is the strongest prognostic marker in OPC and p53 in addition to p16 sup... DisGeNET Detail
Significant correlations were confirmed between p16 positivity and oropharyngeal cancer, MMP1 and p1... DisGeNET Detail
Overall, this study provides evidence of epigenetic changes to the downstream region of the CDKN2A l... DisGeNET Detail
Prognostic value of p16 expression irrespective of human papillomavirus status in patients with orop... DisGeNET Detail
Population-based p16 and HPV positivity rates in oropharyngeal cancer in Southeast Scotland. DisGeNET Detail
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The results showed that the membrane weighted index of β-catenin was inversely correlated with p16 p... DisGeNET Detail
Epigenetic changes in the CDKN2A locus are associated with differential expression of P16INK4A and P... DisGeNET Detail
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Genomic aberrations affecting the genes encoding factor H (FH) and the five FH-related proteins (FHR... DisGeNET Detail
We here evaluated p16 INK4A as a prognostic marker of treatment response and survival in our SCCHN p... DisGeNET Detail
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Diffuse p16 expression was associated with younger age at presentation (P<0.0001), basaloid and wart... DisGeNET Detail
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Immunohistochemistry (IHC) was used to examine STMN1 and p16 expression in fallopian tube specimens ... DisGeNET Detail
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Different roles for p16(INK) (4a) -Rb pathway and INK4a/ARF methylation between adenocarcinomas of g... DisGeNET Detail
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An increased CDKN2A gene expression in carotid plaques may increase the severity of ICA stenosis, th... DisGeNET Detail
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Herein we showed that activation of CD47 in human astrocytoma cell lines U87 and CCF- STTG1 (Grade I... DisGeNET Detail
CDKN2A loss is associated with shortened overall survival in lower-grade (World Health Organization ... DisGeNET Detail
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An increased CDKN2A gene expression in carotid plaques may increase the severity of ICA stenosis, th... DisGeNET Detail
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Barrett's esophagus is thought to progress to esophageal adenocarcinoma (EAC) through a stepwise pro... DisGeNET Detail
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Detection of human papillomavirus infection and p16 immunohistochemistry expression in bladder cance... DisGeNET Detail
Transfection of the DNAzyme caused significant down-regulation of DNMT1 expression and reactivation ... DisGeNET Detail
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However, cases of ambiguous p16(INK4a) overexpression are regularly detected in the head and neck: p... DisGeNET Detail
In a cross-sectional study of 138 women with no history of breast cancer who underwent reduction mam... DisGeNET Detail
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Quantitative analysis of CDKN2A methylation, mRNA, and p16(INK4a) protein expression in children and... DisGeNET Detail
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Molecular subtypes in stage II-III colon cancer defined by genomic instability: early recurrence-ris... DisGeNET Detail
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Vitamin C protects against UV irradiation-induced apoptosis through reactivating silenced tumor supp... DisGeNET Detail
CDKN2a mutation-negative melanoma families have increased risk exclusively for skin cancers but not ... DisGeNET Detail
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Assessment of the prognostic value of methylation status and expression levels of FHIT, GSTP1 and p1... DisGeNET Detail
Methylation of APC and/or p16 was related to advanced staging in non-small cell lung cancer (NSCLC) ... DisGeNET Detail
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Overlapped Transcript Coordinates

Gene Transcript ID Exon Number Chromosome Start Stop Type Amino Mutation Transcript Position Links

Overlapped Transcript

Gene Transcript ID Chromosome Start Stop Links
Gene
-
dbSNP
rs386505388 dbSNP
Genome
hg19
Position
chr9:21,967,751-21,995,300
Variant Type
snv
Variant (CIViC) (CIViC Variant)
MUTATION
Variant URL (CIViC Variant)
https://civic.genome.wustl.edu/links/variants/2704
Variant (CIViC) (CIViC Variant)
LOSS-OF-FUNCTION
Variant URL (CIViC Variant)
https://civic.genome.wustl.edu/links/variants/2708
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