chr4:153684050:> Detail (hg38)

Information

Genome

Assembly Position
hg19 chr4:154,605,202-154,627,412 
hg38 chr4:153,684,050-153,706,260

HGVS

Type Transcript Protein
Summary

MGeND

Clinical significance
Variant entry
GWAS entry
Disease area statistics Show details

Frequency

[No Data.]

Prediction

[No Data.]

ClinVar

Clinical Significance
Review star [No Data.]
Show details
Links
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
[No Data.]
CIViC
[No Data.]
DisGeNET
Score Disease name Description Source Pubmed Links
0.003 Cardiovascular Diseases NA BeFree,GAD Detail
0.080 carotid stenosis NA RGD Detail
<0.001 celiac disease NA BeFree Detail
<0.001 Malignant tumor of cervix NA BeFree Detail
0.005 Chagas Cardiomyopathy NA GAD Detail
<0.001 Chediak-Higashi syndrome For the first time, results from our study indicate defective trafficking of TLR... BeFree 25528552 Detail
0.003 Chlamydia Infections NA BeFree,GAD Detail
0.003 cholangitis NA BeFree,LHGDN Detail
<0.001 Primary biliary cirrhosis NA BeFree Detail
0.005 chorioamnionitis NA GAD,LHGDN Detail
0.002 colitis Our results indicate that S. Typhimurium ΔmsbB triggers exacerbated colitis in t... BeFree 25423082 Detail
0.002 colorectal carcinoma NA BeFree Detail
0.123 Colorectal Neoplasms NA BeFree,CTD_human,LHGDN Detail
<0.001 common variable immunodeficiency NA BeFree Detail
0.002 Connective Tissue Diseases NA GAD Detail
<0.001 corneal ulcer NA BeFree Detail
0.006 Coronary Arteriosclerosis The effect of genetic polymorphisms of TLR2 and TLR4 in Turkish patients with co... BeFree,GAD 25542811 Detail
0.003 Coronary heart disease The effect of genetic polymorphisms of TLR2 and TLR4 in Turkish patients with co... BeFree,GAD 25542811 Detail
<0.001 craniosynostosis NA BeFree Detail
0.004 cystic fibrosis NA BeFree,LHGDN Detail
0.002 cystitis NA GAD Detail
<0.001 dental caries NA BeFree Detail
<0.001 depressive disorder TLR2 and TLR4 risk genotype carrier state and history of childhood emotional, ph... BeFree 25790282 Detail
<0.001 dermatitis TLR2 activation in skin resident cells triggered interleukin-6 (IL-6), which ind... BeFree 25456159 Detail
0.024 Dermatitis, Atopic NA BeFree,GAD,LHGDN Detail
<0.001 Diabetes NA BeFree Detail
0.003 diabetes mellitus HMEC-1 cells (a human microvascular endothelial cell line) were exposed to contr... BeFree,LHGDN 25303153 Detail
0.080 Diabetes Mellitus, Experimental NA RGD Detail
0.009 Diabetes Mellitus, Insulin-Dependent NA BeFree,GAD,LHGDN Detail
0.001 Diabetes Mellitus, Non-Insulin-Dependent Genetic and epigenetic alterations in Toll like receptor 2 and wound healing imp... BeFree 25541252 Detail
<0.001 Diabetic Nephropathy NA BeFree Detail
<0.001 diabetic retinopathy Hyperglycemia induces Toll-like receptor-2 and -4 expression and activity in hum... BeFree 25610879 Detail
<0.001 Duodenal Diseases NA BeFree Detail
0.005 duodenal ulcer NA BeFree,GAD Detail
<0.001 Dyspepsia NA BeFree Detail
<0.001 eclampsia NA BeFree Detail
0.004 Eczema NA BeFree Detail
0.003 Filarial Elephantiases NA BeFree,LHGDN Detail
0.080 Experimental Autoimmune Encephalomyelitis NA RGD Detail
0.002 Endometrial Neoplasms NA GAD Detail
<0.001 endophthalmitis Residual inflammation observed during B. cereus endophthalmitis in TLR2(-/-) mic... BeFree 26195555 Detail
<0.001 Eosinophilia NA BeFree Detail
0.003 Toxic Epidermal Necrolysis NA BeFree,GAD Detail
<0.001 esophagitis NA BeFree Detail
0.120 Eye Infections, Bacterial NA CTD_human Detail
0.080 Fungal eye infections NA RGD Detail
0.002 Fetal Diseases NA GAD Detail
0.002 Fetal Membranes, Premature Rupture NA GAD Detail
0.003 filariasis NA BeFree,GAD Detail
0.005 gastritis NA BeFree,GAD Detail
0.003 Gastritis, Atrophic NA BeFree,GAD Detail
0.002 Female Genital Diseases NA GAD Detail
0.003 gingivitis NA BeFree,LHGDN Detail
<0.001 Glioma Additionally, an established TLR2 neutralizing antibody reduced glioma-induced m... BeFree 25452390 Detail
0.120 IgA glomerulonephritis NA CTD_human Detail
0.002 Head and Neck Neoplasms NA GAD Detail
<0.001 Helminthiasis NA BeFree Detail
0.002 hepatitis B The elevated expressions of TLR2/4 on DC cell surfaces in peripheral blood may s... BeFree 25337250 Detail
0.003 Hepatitis, Alcoholic NA LHGDN Detail
0.007 hepatitis C NA BeFree,LHGDN Detail
0.003 genital herpes NA BeFree,GAD Detail
0.001 Herpes Simplex Infections The PAMP of the HSV-induced innate response is the gH/gL virion glycoprotein, wh... BeFree 25375272 Detail
<0.001 Herpesviridae Infections NA BeFree Detail
0.016 HIV Infections Furthermore, neutrophils from HESN challenged with HIV-1 and stimulated with TLR... BeFree,GAD 25785697 Detail
0.080 Hyperalgesia NA RGD Detail
<0.001 Hyperbilirubinemia NA BeFree Detail
<0.001 hyperglycemia Hyperglycemia induces Toll-like receptor-2 and -4 expression and activity in hum... BeFree 25610879 Detail
0.007 Hypersensitivity NA GAD,LHGDN Detail
0.005 Immediate hypersensitivity NA GAD Detail
0.001 Hypertensive disease In men, TLR1, TLR2, and TLR3 were associated with lipid and TLR8 with hypertensi... BeFree 25657311 Detail
0.001 Hypertensive disease Candesartan cilexetil, a drug approved for treating hypertension and that inhibi... BeFree 25969543 Detail
0.080 ileitis NA RGD Detail
0.221 Inflammation NA CTD_human,GAD,LHGDN,RGD Detail
0.002 Inflammatory Bowel Diseases Polymorphisms in the inflammatory pathway genes TLR2, TLR4, TLR9, LY96, NFKBIA, ... BeFree 24971461 Detail
0.002 influenza We previously reported that pneumococcus, one of the commonly carried bacteria i... BeFree 24903905 Detail
0.002 Insulin resistance NA GAD Detail
<0.001 irritable bowel syndrome NA BeFree Detail
0.002 ischemia Toll-like receptor 2 mediates ischemia-reperfusion injury of the small intestine... BeFree 25329155 Detail
0.201 keratitis NA BeFree,CTD_human,RGD Detail
<0.001 Keratoconjunctivitis, Vernal NA BeFree Detail
<0.001 Kidney Diseases NA BeFree Detail
<0.001 Kidney Failure, Acute NA BeFree Detail
0.003 Kidney Failure, Chronic NA LHGDN Detail
0.002 Premature Obstetric Labor NA GAD Detail
<0.001 Legionnaires' disease NA BeFree Detail
0.001 Leishmaniasis, Cutaneous NA BeFree Detail
<0.001 Leishmaniasis, Visceral L. donovani increases the expression of TLR4 and TLR9 in patients with VL and TL... BeFree 25982946 Detail
0.132 leprosy NA BeFree,CTD_human,GAD Detail
0.007 Leprosy, Lepromatous NA BeFree,LHGDN Detail
<0.001 chronic lymphocytic leukemia NA BeFree Detail
<0.001 Leukemia, Myelocytic, Acute Moreover, we observed that expression of TLR2 and TLR4 was significantly higher ... BeFree 25412934 Detail
<0.001 Leukemia, Myelocytic, Acute Polymorphisms of Toll-like receptors (TLR2 and TLR4) are associated with the ris... BeFree 25427560 Detail
<0.001 Globoid cell leukodystrophy NA BeFree Detail
0.002 liver cirrhosis NA BeFree Detail
0.080 Liver Cirrhosis, Experimental NA RGD Detail
0.003 Liver diseases This novel TLR2-S100A9-CXCL-2 pathway may be of use in development of new strate... BeFree,LHGDN 24333183 Detail
<0.001 Liver neoplasms NA BeFree Detail
0.089 Lung diseases NA BeFree,GAD,LHGDN,RGD Detail
0.002 Lung Diseases, Fungal NA GAD Detail
0.015 Tuberculosis, Pulmonary In the present study, we investigated whether variants in the TLR-1 1805T/G (Ile... BeFree 20797905 Detail
0.013 Chronic Obstructive Airway Disease NA BeFree,GAD,LHGDN Detail
<0.001 Lupus Vulgaris Hence, this study was carried out to analyze the G to A and C to T transitions i... BeFree 25466615 Detail
<0.001 Lupus Erythematosus, Discoid Hence, this study was carried out to analyze the G to A and C to T transitions i... BeFree 25466615 Detail
0.002 Lupus Erythematosus, Systemic Susceptibility to SLE in South Indian Tamils may be influenced by genetic select... BeFree 25466615 Detail
0.002 Lupus Erythematosus, Systemic After reading the article Susceptibility to SLE in South Indian Tamils may be in... BeFree 25879159 Detail
0.002 Lupus Erythematosus, Systemic Increased expression of TLR2 in CD4(+) T cells from SLE patients enhances immune... BeFree 26079624 Detail
0.002 lymphoma NA GAD Detail
<0.001 Lymphoma, Follicular NA BeFree Detail
0.003 Lymphoma, Non-Hodgkin NA BeFree,GAD Detail
0.007 malaria Of particular importance, we revealed characteristic expression changes in the h... BeFree,GAD,LHGDN 25091627 Detail
0.003 Malaria, Cerebral NA BeFree,GAD Detail
0.007 Malaria, Falciparum NA GAD Detail
0.002 Malignant neoplasm of stomach Statistical analyses assessing the joint effect of H. pylori infection and the s... BeFree 24929142 Detail
<0.001 measles NA BeFree Detail
0.003 melanoma NA LHGDN Detail
<0.001 melioidosis NA BeFree Detail
<0.001 meningitis NA BeFree Detail
<0.001 Meningitis, Listeria NA BeFree Detail
0.003 meningococcal meningitis NA BeFree,GAD Detail
<0.001 Meningitis, Pneumococcal NA BeFree Detail
0.003 Meningococcal Infections NA BeFree,GAD Detail
0.002 Metaplasia NA GAD Detail
<0.001 Microangiopathy, Diabetic Collectively, our results suggest that targeting the signalling pathway of TLR2 ... BeFree 25303153 Detail
<0.001 mitral valve stenosis NA BeFree Detail
<0.001 Mucocutaneous Lymph Node Syndrome NA BeFree Detail
0.002 multiple myeloma NA GAD Detail
0.003 multiple sclerosis NA BeFree,GAD Detail
0.002 Musculoskeletal Diseases NA GAD Detail
0.002 Mycobacterium avium-intracellulare Infection NA GAD Detail
0.002 Mycobacterium Infections NA BeFree Detail
0.002 Mycobacterium Infections, Nontuberculous NA GAD Detail
<0.001 Mycoplasma Infections NA BeFree Detail
0.002 Mycoses Moreover, we observed that expression of TLR2 and TLR4 was significantly higher ... BeFree 25412934 Detail
0.003 mycosis fungoides NA BeFree,LHGDN Detail
0.002 myocardial infarction NA GAD Detail
0.080 Myocardial Reperfusion Injury NA RGD Detail
0.003 Nasal Polyps Patients with CRSwNP (n = 16) and CRSsNP (n = 20) showed lower mean expression o... BeFree,GAD 25198021 Detail
0.002 Neoplasm Recurrence, Local NA GAD Detail
0.080 Neuritis, Autoimmune, Experimental NA RGD Detail
<0.001 Neurosyphilis A common TLR1 polymorphism is associated with an increased risk of laboratory-de... BeFree 24922103 Detail
<0.001 Nodule NA BeFree Detail
0.003 obesity However, a high-fat diet activates TLR-2s, and obesity activates TLR-4s and indu... BeFree,GAD 25840582 Detail
<0.001 Osteitis Toll-like receptor 2 subfamily gene polymorphisms are associated with Bacillus C... BeFree 25605403 Detail
<0.001 Degenerative polyarthritis NA BeFree Detail
<0.001 osteomyelitis Involvement of toll-like receptor 2 and pro-apoptotic signaling pathways in bone... BeFree 25503704 Detail
0.003 otitis media NA BeFree,GAD Detail
<0.001 Otitis Media with Effusion NA BeFree Detail
<0.001 ovarian carcinoma NA BeFree Detail
0.080 Pain NA RGD Detail
<0.001 Pancreatic Neoplasm NA BeFree Detail
0.080 pancreatitis NA RGD Detail
<0.001 papilloma The expression profile of pattern recognition receptors in HIBCPP cells and the ... BeFree 25347003 Detail
<0.001 Paratuberculosis NA BeFree Detail
<0.001 Parkinson disease We used flow cytometry and western blots to detect toll-like receptor 2 and 4 ex... BeFree 25522431 Detail
<0.001 Parkinson disease We validated the authenticity of this tool in vivo by analysing the expression o... BeFree 25653107 Detail
0.002 Peptic Ulcer NA GAD Detail
0.004 familial Mediterranean fever TLR2 and TLR4 gene expression levels and associated factors during acute attack ... BeFree,GAD 25208763 Detail
0.017 periodontitis NA BeFree,GAD,LHGDN Detail
0.002 Periodontitis, Juvenile NA GAD Detail
<0.001 peritonitis NA BeFree Detail
0.008 Pneumococcal Infections TBX21 participates in innate immune response by regulating Toll-like receptor 2 ... BeFree,GAD 24903905 Detail
<0.001 Lobar Pneumonia NA BeFree Detail
<0.001 polyps NA BeFree Detail
0.010 pre-eclampsia NA GAD,LHGDN Detail
0.002 Pregnancy Complications, Hematologic NA GAD Detail
0.002 Pregnancy Complications, Infectious NA GAD Detail
<0.001 ectopic pregnancy NA BeFree Detail
0.001 psoriasis We analyzed the role of functional single-nucleotide polymorphisms (SNPs) of TLR... BeFree 25561051 Detail
0.002 Puerperal Disorders NA GAD Detail
<0.001 pulmonary emphysema NA BeFree Detail
<0.001 pulmonary fibrosis NA BeFree Detail
0.002 pyelonephritis NA GAD Detail
<0.001 Radiation Syndrome NA BeFree Detail
0.200 Reperfusion Injury NA CTD_human,RGD Detail
0.005 Respiratory Syncytial Virus Infections NA BeFree,GAD Detail
0.006 rheumatic fever NA BeFree,GAD,LHGDN Detail
<0.001 rheumatic heart disease NA BeFree Detail
0.003 rhinitis NA BeFree,GAD Detail
<0.001 rosacea NA BeFree Detail
<0.001 Rotavirus Infections NA BeFree Detail
0.002 Salmonella infections NA GAD Detail
0.006 sarcoidosis NA BeFree,GAD,LHGDN Detail
<0.001 Sarcoidosis, Pulmonary NA BeFree Detail
<0.001 systemic scleroderma NA BeFree Detail
0.001 Septicaemia due to gram-negative organism, unspecified NA BeFree Detail
<0.001 Gram positive sepsis NA BeFree Detail
0.005 Septicemia TLR-2 and TLR-4 expression in monocytes of newborns with late-onset sepsis. BeFree 24878008 Detail
0.005 Septicemia In patients with neutropenic fever, the mRNA expression of TLR2 and TLR4 was sig... BeFree 25412934 Detail
<0.001 Sexually Transmitted Diseases, Bacterial NA BeFree Detail
0.003 Shock NA LHGDN Detail
0.005 sinusitis NA GAD Detail
0.003 Dermatologic disorders NA BeFree,GAD Detail
0.002 Skin Diseases, Infectious NA BeFree Detail
0.125 Staphylococcal Infections NA BeFree,CTD_human,GAD Detail
0.003 Stevens-Johnson syndrome NA BeFree,GAD Detail
0.012 Stomach Neoplasms NA GAD,LHGDN Detail
<0.001 gastric ulcer NA BeFree Detail
0.002 Streptococcal Infections NA GAD Detail
<0.001 Stress, Psychological Combined effect of TLR2 gene polymorphism and early life stress on the age at on... BeFree 25790282 Detail
<0.001 syphilis Polymorphisms in the genes for TLR1 (a T→G mutation at position 1805), TLR2 (a G... BeFree 24922103 Detail
0.002 Tobacco use disorder NA GAD Detail
<0.001 Septic Toxemia NA BeFree Detail
<0.001 Trichomonas Infections NA BeFree Detail
<0.001 Chagas disease NA BeFree Detail
0.008 Tuberculosis, Meningeal NA BeFree,GAD,LHGDN Detail
<0.001 Tuberculosis, Miliary NA BeFree Detail
0.015 Tuberculosis, Pulmonary Aberrant Toll-like receptor 2 promoter methylation in blood cells from patients ... BeFree,GAD 25218055 Detail
0.015 Tuberculosis, Pulmonary Our results suggest that genetic variation in TLR2, 4, 8 and 9, implicating TLR-... BeFree,GAD 25928077 Detail
<0.001 tuberous sclerosis NA BeFree Detail
<0.001 tularemia NA BeFree Detail
0.009 urinary tract infection NA BeFree,GAD,LHGDN Detail
<0.001 uveitis Residual inflammation observed during B. cereus endophthalmitis in TLR2(-/-) mic... BeFree 26195555 Detail
0.003 anterior uveitis NA LHGDN Detail
<0.001 Vesico-Ureteral Reflux NA BeFree Detail
0.004 Virus Diseases NA BeFree,GAD Detail
<0.001 vitiligo NA BeFree Detail
<0.001 intestinal volvulus NA BeFree Detail
<0.001 Yersinia infections NA BeFree Detail
0.014 Helicobacter Infections NA GAD Detail
<0.001 Lymphoma, Large-Cell, Follicular NA BeFree Detail
0.005 Bronchial Hyperreactivity NA GAD Detail
0.008 bacterial vaginosis Although mucosal fluids from BV patients exhibit increases in proinflammatory cy... BeFree,GAD,LHGDN 25280956 Detail
0.002 Neoplasms, Second Primary NA GAD Detail
<0.001 gestational diabetes NA BeFree Detail
<0.001 ehrlichiosis NA BeFree Detail
<0.001 Polyendocrinopathies, Autoimmune These results suggest that immune responses induced by PGA occur via TLR2, TLR6,... BeFree 26195551 Detail
<0.001 Gram-Negative Bacterial Infections NA BeFree Detail
0.006 Gram-Positive Bacterial Infections NA BeFree,GAD,LHGDN Detail
0.005 Arthritis, Reactive NA BeFree,GAD,LHGDN Detail
<0.001 Meningitis, Bacterial NA BeFree Detail
<0.001 acute leukemia We especially observed that mRNA expression of TLR2 and TLR4 was significantly h... BeFree 25624047 Detail
<0.001 Chronic sinusitis NA BeFree Detail
<0.001 Active tuberculosis NA BeFree Detail
0.012 Premature Birth NA GAD,LHGDN Detail
0.003 low tension glaucoma NA BeFree,GAD Detail
<0.001 Idiopathic pulmonary hypertension NA BeFree Detail
<0.001 Streptococcal sepsis NA BeFree Detail
<0.001 Malignant neoplasm of gallbladder NA BeFree Detail
<0.001 Secondary malignant neoplasm of lung NA BeFree Detail
<0.001 Hearing Loss, Mixed Conductive-Sensorineural NA BeFree Detail
<0.001 acute myocardial infarction NA BeFree Detail
<0.001 Streptococcal pneumonia NA BeFree Detail
<0.001 allergic asthma NA BeFree Detail
<0.001 HELLP syndrome NA BeFree Detail
<0.001 Aortic Aneurysm, Abdominal NA BeFree Detail
<0.001 Tumor Progression NA BeFree Detail
<0.001 Diabetes, Autoimmune In this review, we summarized the biological characteristics, signaling mechanis... BeFree 24352680 Detail
0.004 Lichen Planus, Oral NA BeFree,LHGDN Detail
<0.001 pediatric acute myeloblastic leukemia NA BeFree Detail
<0.001 Reactive systemic amyloidosis NA BeFree Detail
<0.001 gallbladder carcinoma NA BeFree Detail
<0.001 pancreatic carcinoma NA BeFree Detail
<0.001 pelvic inflammatory disease NA BeFree Detail
0.080 Dyslipidemias NA BeFree,RGD Detail
0.002 Malignant neoplasm of lung NA GAD Detail
<0.001 Lyme Arthritis NA BeFree Detail
<0.001 Mucosa-Associated Lymphoid Tissue Lymphoma NA BeFree Detail
0.003 Parasitemia NA BeFree,GAD Detail
0.003 Systemic Inflammatory Response Syndrome NA BeFree,GAD Detail
0.100 Sepsis TLR-2 and TLR-4 expression in monocytes of newborns with late-onset sepsis. BeFree,GAD,RGD 24878008 Detail
0.100 Sepsis In patients with neutropenic fever, the mRNA expression of TLR2 and TLR4 was sig... BeFree,GAD,RGD 25412934 Detail
<0.001 Asymptomatic bacteriuria NA BeFree Detail
<0.001 Childhood asthma NA BeFree Detail
<0.001 Acute respiratory failure NA BeFree Detail
<0.001 Coronary arteritis NA BeFree Detail
<0.001 Miller Dieker syndrome NA BeFree Detail
0.005 Chronic Periodontitis NA BeFree,GAD Detail
<0.001 Chronic colitis NA BeFree Detail
0.080 Pancreatitis, Acute Necrotizing NA BeFree,RGD Detail
<0.001 chronic purulent otitis media The etiology, pathological profile, expression levels of TLR2, TLR4, TLR5, TLR9 ... BeFree 24882571 Detail
<0.001 Impaired glucose tolerance NA BeFree Detail
<0.001 Coinfection NA BeFree Detail
<0.001 Primary bacterial peritonitis NA BeFree Detail
0.080 Herpes encephalitis NA RGD Detail
<0.001 Extreme exhaustion Moreover, the polymorphisms in the toll-like receptor 1 (TLR1) and TLR2 genes va... BeFree 25200597 Detail
<0.001 Carcinoma breast stage IV NA BeFree Detail
<0.001 Adenocarcinoma Of Esophagus NA BeFree Detail
<0.001 bubonic plague NA BeFree Detail
<0.001 Disease caused by Shigella dysenteriae NA BeFree Detail
0.003 cervix carcinoma NA BeFree,GAD Detail
<0.001 Restenosis NA BeFree Detail
<0.001 Chronic ulcer TLR2 down regulation in wounds of T2DM patients compared to non diabetic patient... BeFree 25541252 Detail
<0.001 Superficial ulcer NA BeFree Detail
<0.001 Hyperplastic Polyp NA BeFree Detail
<0.001 Impaired cognition NA BeFree Detail
<0.001 Stable angina NA BeFree Detail
<0.001 Chronic liver disease NA BeFree Detail
<0.001 Microscopic Polyangiitis Single nucleotide polymorphisms in the toll-like receptor 2 (TLR2) gene are asso... BeFree 25180613 Detail
<0.001 Leprosy reversal reaction NA BeFree Detail
<0.001 Erythema nodosum leprosum NA BeFree Detail
<0.001 Malignant neoplasm of pancreas NA BeFree Detail
<0.001 Depressive episode, unspecified TLR2 and TLR4 risk genotype carrier state and history of childhood emotional, ph... BeFree 25790282 Detail
0.002 Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site NA BeFree Detail
0.005 Malignant neoplasm of prostate NA GAD Detail
0.080 Endotoxemia NA RGD Detail
<0.001 Pulmonary Cystic Fibrosis NA BeFree Detail
0.002 Immune thrombocytopenic purpura NA GAD Detail
<0.001 Supragingival dental plaque NA BeFree Detail
<0.001 Simple diverticular disease We investigated the pattern of TLRs 2 and 4 and the intestinal homing in patient... BeFree 25133198 Detail
<0.001 lupus erythematosus Hence, this study was carried out to analyze the G to A and C to T transitions i... BeFree 25466615 Detail
<0.001 Prosthetic joint infection NA BeFree Detail
<0.001 Cortical Dysplasia NA BeFree Detail
<0.001 Ichthyosis bullosa of Siemens NA BeFree Detail
<0.001 Alzheimer Disease, Late Onset Association of CLU and TLR2 gene polymorphisms with late-onset Alzheimer disease... BeFree 26738351 Detail
<0.001 Overweight NA BeFree Detail
<0.001 Chlamydia trachomatis infection NA BeFree Detail
<0.001 Acute Q fever NA BeFree Detail
0.080 Necrotizing Enterocolitis NA RGD Detail
<0.001 acute pyelonephritis NA BeFree Detail
<0.001 Sleep Apnea, Obstructive NA BeFree Detail
0.001 Metabolic syndrome X Evaluation of Toll-Like receptor 2 and 4 RNA expression and the cytokine profile... BeFree 25329057 Detail
0.001 Metabolic syndrome X Down-regulation of miR-144 elicits proinflammatory cytokine production by target... BeFree 25534427 Detail
0.003 Hepatitis B, Chronic NA BeFree,LHGDN Detail
0.007 Hepatitis C, Chronic NA BeFree,GAD,LHGDN Detail
<0.001 Mixed cryoglobulinemia NA BeFree Detail
<0.001 Chagas disease T. cruzi-infected individuals who are heterozygous for the MAL/TIRAP S180L varia... BeFree 19456234 Detail
<0.001 Spondylarthritis This study did not show significant associations of SNP S180L of the TLR2/4 adap... BeFree 18073264 Detail
<0.001 Carotid Atherosclerosis NA BeFree Detail
0.001 Carcinogenesis A cell-intrinsic role for TLR2-MYD88 in intestinal and breast epithelia and onco... BeFree 25362351 Detail
<0.001 toxic shock syndrome NA BeFree Detail
<0.001 breast carcinoma NA BeFree Detail
<0.001 Tuberculosis, extrapulmonary NA BeFree Detail
<0.001 colon carcinoma Expression of TLR2 and TLR4 receptor proteins on colon cancer cells were confirm... BeFree 24390484 Detail
<0.001 Acute anterior uveitis NA BeFree Detail
<0.001 acne NA BeFree Detail
<0.001 Viral respiratory infection NA BeFree Detail
<0.001 allergic symptom NA BeFree Detail
<0.001 Febrile Neutropenia In patients with neutropenic fever, the mRNA expression of TLR2 and TLR4 was sig... BeFree 25412934 Detail
<0.001 Experimental Pneumococcal Meningitis NA BeFree Detail
0.002 Helicobacter pylori infection Statistical analyses assessing the joint effect of H. pylori infection and the s... BeFree 24929142 Detail
0.002 Helicobacter pylori infection We conclude that TLR10 is a functional receptor involved in the innate immune re... BeFree 25977263 Detail
0.002 Carcinoma in situ of uterine cervix NA GAD Detail
<0.001 Peritoneal infections NA BeFree Detail
<0.001 Endothelial dysfunction This study examined the role of TLR2 and 4 in regulating inflammation and endoth... BeFree 25303153 Detail
0.003 Pancolitis NA BeFree,GAD Detail
<0.001 Carditis NA BeFree Detail
<0.001 Infectious disease of lung High mobility group box 1 (HMGB1), a recently discovered potent pro-inflammatory... BeFree 24099632 Detail
<0.001 Candidemia NA BeFree Detail
0.120 Cardiomyopathies NA CTD_human Detail
<0.001 ovarian neoplasm NA BeFree Detail
<0.001 Oropharyngeal candidiasis NA BeFree Detail
<0.001 Renal ischaemia NA BeFree Detail
<0.001 Vascular inflammations Collectively, our results suggest that targeting the signalling pathway of TLR2 ... BeFree 25303153 Detail
<0.001 Ischemic stroke NA BeFree Detail
<0.001 Acute coronary syndrome NA BeFree Detail
0.003 coronary restenosis NA LHGDN Detail
<0.001 Candida sepsis NA BeFree Detail
<0.001 Spondylarthritis NA BeFree Detail
0.080 Arthritis, Experimental NA BeFree,RGD Detail
<0.001 Malignant neoplasm of ovary NA BeFree Detail
0.003 Stenosis NA LHGDN Detail
<0.001 Fungal keratitis NA BeFree Detail
<0.001 Inflammatory disorder NA BeFree Detail
<0.001 Eosinophilic disorder NA BeFree Detail
<0.001 Herpes simplex type 1 infection NA BeFree Detail
<0.001 Staphylococcus aureus infection NA BeFree Detail
<0.001 AIDS-Related Non-Hodgkin Lymphoma NA BeFree Detail
<0.001 Marginal Zone B-Cell Lymphoma NA BeFree Detail
<0.001 Bacteroides fragilis infection in conditions classified elsewhere and of unspecified site NA BeFree Detail
0.004 colorectal cancer NA BeFree,GAD Detail
<0.001 fertility disorders NA BeFree Detail
<0.001 Non-Malignant Ascites Adverse Event NA BeFree Detail
0.080 Renal Insufficiency NA RGD Detail
0.001 Cirrhosis NA BeFree Detail
<0.001 Disorder characterized by eosinophilia NA BeFree Detail
<0.001 Peripheral Arterial Diseases Our aim is to study a transcriptional activation pathway of the innate immune sy... BeFree 24472415 Detail
<0.001 PERIODONTITIS, LOCALIZED AGGRESSIVE NA BeFree Detail
<0.001 Aggressive periodontitis, generalized NA BeFree Detail
<0.001 Severe Sepsis NA BeFree Detail
<0.001 Idiopathic Pulmonary Fibrosis NA BeFree Detail
<0.001 IMMUNE SUPPRESSION NA BeFree Detail
<0.001 VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding) NA BeFree Detail
0.003 coronary artery disease The effect of genetic polymorphisms of TLR2 and TLR4 in Turkish patients with co... BeFree,LHGDN 25542811 Detail
0.002 liver carcinoma NA BeFree Detail
<0.001 Infection of bone NA BeFree Detail
<0.001 Reproductive tract infection NA BeFree Detail
<0.001 Destructive Arthritis NA BeFree Detail
0.005 Allergic rhinitis (disorder) NA BeFree,GAD Detail
<0.001 MYD88 Deficiency NA BeFree Detail
<0.001 Infectious Otitis Media NA BeFree Detail
0.002 Infection of amniotic sac and membranes, unspecified, unspecified trimester, not applicable or unspecified NA GAD Detail
<0.001 Nasopharyngeal carcinoma NA BeFree Detail
<0.001 Indolent ulcer TLR2 down regulation in wounds of T2DM patients compared to non diabetic patient... BeFree 25541252 Detail
<0.001 limb ischemia NA BeFree Detail
<0.001 Pulmonary arterial hypertension NA BeFree Detail
<0.001 Nonalcoholic Steatohepatitis Down-regulation of miR-144 elicits proinflammatory cytokine production by target... BeFree 25534427 Detail
<0.001 Ischemic Cerebrovascular Accident NA BeFree Detail
0.002 Allergic disposition NA BeFree Detail
<0.001 aortic valve disease 2 NA BeFree Detail
<0.001 Neutrophilia (disorder) NA BeFree Detail
0.024 Infection NA GAD,LHGDN Detail
<0.001 Pulmonary hypertension, primary, 1, with hereditary hemorrhagic telangiectasia NA BeFree Detail
<0.001 Rheumatic fever in children NA BeFree Detail
<0.001 Disorder of Achilles tendon NA BeFree Detail
0.003 Acne Vulgaris NA BeFree,LHGDN Detail
<0.001 Acute Disease NA BeFree Detail
<0.001 acute pancreatitis Effect of lornoxicam therapy on expression of TLR2 and TLR4 mRNA during systemic... BeFree 25403387 Detail
<0.001 Alzheimer's disease NA BeFree Detail
0.002 amyloidosis NA GAD Detail
0.003 Anoxia NA LHGDN Detail
<0.001 aortic valve stenosis NA BeFree Detail
<0.001 Arterial Occlusive Diseases NA BeFree Detail
0.003 arteriosclerosis NA BeFree Detail
0.004 arthritis NA BeFree,LHGDN Detail
0.138 rheumatoid arthritis Our results show that rheumatoid arthritis synovial fibroblasts (RASF) express a... BeFree,CTD_human,GAD,LHGDN 24936783 Detail
0.005 aspergillosis NA GAD Detail
0.002 Aspergillosis, Allergic Bronchopulmonary NA GAD Detail
0.013 atherosclerosis NA BeFree,GAD,LHGDN Detail
<0.001 Autoimmune Diseases TLR2 and TLR4 in autoimmune diseases: a comprehensive review. BeFree 24352680 Detail
<0.001 Autoimmune Diseases TLR2, a PRR, recognizes exogenous PAMPs, and endogenous damage-associated molecu... BeFree 26079624 Detail
0.008 Bacteremia NA BeFree,GAD Detail
0.025 Bacterial Infections Moreover, we observed that expression of TLR2 and TLR4 was significantly higher ... BeFree,GAD,LHGDN 25412934 Detail
0.080 Pneumonia, Bacterial NA RGD Detail
0.002 bacteriuria NA GAD Detail
0.009 Behcet Syndrome The role of TLR2 and 4 in Behçet's disease pathogenesis. BeFree,GAD 23940075 Detail
<0.001 bipolar disorder Combined effect of TLR2 gene polymorphism and early life stress on the age at on... BeFree 25790282 Detail
0.005 Malignant neoplasm of urinary bladder NA GAD Detail
<0.001 borderline personality disorder NA BeFree Detail
<0.001 Brain Neoplasms NA BeFree Detail
0.003 Malignant neoplasm of breast NA BeFree,GAD Detail
<0.001 bronchiectasis NA BeFree Detail
<0.001 bronchiolitis NA BeFree Detail
0.002 bronchiolitis obliterans NA GAD Detail
0.002 Bronchiolitis, Viral NA GAD Detail
<0.001 bronchopulmonary dysplasia NA BeFree Detail
0.003 burning mouth syndrome NA BeFree,LHGDN Detail
0.002 candidiasis NA GAD Detail
<0.001 cutaneous candidiasis NA BeFree Detail
0.002 oral candidiasis NA GAD Detail
<0.001 Malignant tumor of colon Expression of TLR2 and TLR4 receptor proteins on colon cancer cells were confirm... BeFree 24390484 Detail
<0.001 Merkel cell carcinoma TLR 2, 4, 5, 7 and 9 appear to reflect certain clinicopathological variables and... BeFree 25862837 Detail
<0.001 Non-small cell lung carcinoma NA BeFree Detail
Annotation

Annotations

DescrptionSourceLinks
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For the first time, results from our study indicate defective trafficking of TLR-2 and TLR-4 contrib... DisGeNET Detail
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Our results indicate that S. Typhimurium ΔmsbB triggers exacerbated colitis in the absence of Nod1 a... DisGeNET Detail
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The effect of genetic polymorphisms of TLR2 and TLR4 in Turkish patients with coronary artery diseas... DisGeNET Detail
The effect of genetic polymorphisms of TLR2 and TLR4 in Turkish patients with coronary artery diseas... DisGeNET Detail
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TLR2 and TLR4 risk genotype carrier state and history of childhood emotional, physical and sexual ab... DisGeNET Detail
TLR2 activation in skin resident cells triggered interleukin-6 (IL-6), which induced suppressive MDS... DisGeNET Detail
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HMEC-1 cells (a human microvascular endothelial cell line) were exposed to control (5 mM), 30 mM (hi... DisGeNET Detail
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Genetic and epigenetic alterations in Toll like receptor 2 and wound healing impairment in type 2 di... DisGeNET Detail
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Hyperglycemia induces Toll-like receptor-2 and -4 expression and activity in human microvascular ret... DisGeNET Detail
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Residual inflammation observed during B. cereus endophthalmitis in TLR2(-/-) mice led us to investig... DisGeNET Detail
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Additionally, an established TLR2 neutralizing antibody reduced glioma-induced microglial MT1-MMP ex... DisGeNET Detail
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The elevated expressions of TLR2/4 on DC cell surfaces in peripheral blood may synergistically promo... DisGeNET Detail
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The PAMP of the HSV-induced innate response is the gH/gL virion glycoprotein, which interacts with α... DisGeNET Detail
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Furthermore, neutrophils from HESN challenged with HIV-1 and stimulated with TLR2 and TLR4 agonists,... DisGeNET Detail
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Hyperglycemia induces Toll-like receptor-2 and -4 expression and activity in human microvascular ret... DisGeNET Detail
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In men, TLR1, TLR2, and TLR3 were associated with lipid and TLR8 with hypertension treatment. DisGeNET Detail
Candesartan cilexetil, a drug approved for treating hypertension and that inhibits the expression of... DisGeNET Detail
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Polymorphisms in the inflammatory pathway genes TLR2, TLR4, TLR9, LY96, NFKBIA, NFKB1, TNFA, TNFRSF1... DisGeNET Detail
We previously reported that pneumococcus, one of the commonly carried bacteria in the nasopharynx, r... DisGeNET Detail
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Toll-like receptor 2 mediates ischemia-reperfusion injury of the small intestine in adult mice. DisGeNET Detail
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L. donovani increases the expression of TLR4 and TLR9 in patients with VL and TLR2 in THP1 cells, su... DisGeNET Detail
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Moreover, we observed that expression of TLR2 and TLR4 was significantly higher in patients with AML... DisGeNET Detail
Polymorphisms of Toll-like receptors (TLR2 and TLR4) are associated with the risk of infectious comp... DisGeNET Detail
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This novel TLR2-S100A9-CXCL-2 pathway may be of use in development of new strategies for selectively... DisGeNET Detail
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In the present study, we investigated whether variants in the TLR-1 1805T/G (Ile602Ser), TLR-2 2258G... DisGeNET Detail
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Hence, this study was carried out to analyze the G to A and C to T transitions in TLR2 and TLR9 gene... DisGeNET Detail
Hence, this study was carried out to analyze the G to A and C to T transitions in TLR2 and TLR9 gene... DisGeNET Detail
Susceptibility to SLE in South Indian Tamils may be influenced by genetic selection pressure on TLR2... DisGeNET Detail
After reading the article Susceptibility to SLE in South Indian Tamils may be influenced by genetic ... DisGeNET Detail
Increased expression of TLR2 in CD4(+) T cells from SLE patients enhances immune reactivity and prom... DisGeNET Detail
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Of particular importance, we revealed characteristic expression changes in the human innate immune r... DisGeNET Detail
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Statistical analyses assessing the joint effect of H. pylori infection and the selected polymorphism... DisGeNET Detail
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Collectively, our results suggest that targeting the signalling pathway of TLR2 and 4 may be of ther... DisGeNET Detail
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Moreover, we observed that expression of TLR2 and TLR4 was significantly higher in patients with AML... DisGeNET Detail
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Patients with CRSwNP (n = 16) and CRSsNP (n = 20) showed lower mean expression of TLR2 (p < 0.05) co... DisGeNET Detail
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A common TLR1 polymorphism is associated with an increased risk of laboratory-defined neurosyphilis,... DisGeNET Detail
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However, a high-fat diet activates TLR-2s, and obesity activates TLR-4s and induces spontaneous incr... DisGeNET Detail
Toll-like receptor 2 subfamily gene polymorphisms are associated with Bacillus Calmette-Guérin ostei... DisGeNET Detail
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Involvement of toll-like receptor 2 and pro-apoptotic signaling pathways in bone remodeling in osteo... DisGeNET Detail
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The expression profile of pattern recognition receptors in HIBCPP cells and the response to specific... DisGeNET Detail
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We used flow cytometry and western blots to detect toll-like receptor 2 and 4 expression in blood an... DisGeNET Detail
We validated the authenticity of this tool in vivo by analysing the expression of toll-like receptor... DisGeNET Detail
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TLR2 and TLR4 gene expression levels and associated factors during acute attack and attack-free peri... DisGeNET Detail
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TBX21 participates in innate immune response by regulating Toll-like receptor 2 expression in Strept... DisGeNET Detail
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We analyzed the role of functional single-nucleotide polymorphisms (SNPs) of TLR2, 5, 4, and 9 in cl... DisGeNET Detail
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TLR-2 and TLR-4 expression in monocytes of newborns with late-onset sepsis. DisGeNET Detail
In patients with neutropenic fever, the mRNA expression of TLR2 and TLR4 was significant higher in s... DisGeNET Detail
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Combined effect of TLR2 gene polymorphism and early life stress on the age at onset of bipolar disor... DisGeNET Detail
Polymorphisms in the genes for TLR1 (a T→G mutation at position 1805), TLR2 (a G→A mutation at posit... DisGeNET Detail
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Aberrant Toll-like receptor 2 promoter methylation in blood cells from patients with pulmonary tuber... DisGeNET Detail
Our results suggest that genetic variation in TLR2, 4, 8 and 9, implicating TLR-related pathways aff... DisGeNET Detail
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Residual inflammation observed during B. cereus endophthalmitis in TLR2(-/-) mice led us to investig... DisGeNET Detail
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Although mucosal fluids from BV patients exhibit increases in proinflammatory cytokines and Toll-lik... DisGeNET Detail
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These results suggest that immune responses induced by PGA occur via TLR2, TLR6, CD14, and MyD88 thr... DisGeNET Detail
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We especially observed that mRNA expression of TLR2 and TLR4 was significantly higher in patients wi... DisGeNET Detail
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In this review, we summarized the biological characteristics, signaling mechanisms of TLR2/4, the ne... DisGeNET Detail
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TLR-2 and TLR-4 expression in monocytes of newborns with late-onset sepsis. DisGeNET Detail
In patients with neutropenic fever, the mRNA expression of TLR2 and TLR4 was significant higher in s... DisGeNET Detail
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The etiology, pathological profile, expression levels of TLR2, TLR4, TLR5, TLR9 and proinflammatory ... DisGeNET Detail
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Moreover, the polymorphisms in the toll-like receptor 1 (TLR1) and TLR2 genes varied between the pig... DisGeNET Detail
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TLR2 down regulation in wounds of T2DM patients compared to non diabetic patients may lead to develo... DisGeNET Detail
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Single nucleotide polymorphisms in the toll-like receptor 2 (TLR2) gene are associated with microsco... DisGeNET Detail
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TLR2 and TLR4 risk genotype carrier state and history of childhood emotional, physical and sexual ab... DisGeNET Detail
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We investigated the pattern of TLRs 2 and 4 and the intestinal homing in patients with UDD before an... DisGeNET Detail
Hence, this study was carried out to analyze the G to A and C to T transitions in TLR2 and TLR9 gene... DisGeNET Detail
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Association of CLU and TLR2 gene polymorphisms with late-onset Alzheimer disease in a northwestern I... DisGeNET Detail
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Evaluation of Toll-Like receptor 2 and 4 RNA expression and the cytokine profile in postmenopausal w... DisGeNET Detail
Down-regulation of miR-144 elicits proinflammatory cytokine production by targeting toll-like recept... DisGeNET Detail
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T. cruzi-infected individuals who are heterozygous for the MAL/TIRAP S180L variant that leads to a d... DisGeNET Detail
This study did not show significant associations of SNP S180L of the TLR2/4 adaptor protein TIRAP wi... DisGeNET Detail
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A cell-intrinsic role for TLR2-MYD88 in intestinal and breast epithelia and oncogenesis. DisGeNET Detail
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Expression of TLR2 and TLR4 receptor proteins on colon cancer cells were confirmed by immunohistoche... DisGeNET Detail
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In patients with neutropenic fever, the mRNA expression of TLR2 and TLR4 was significant higher in s... DisGeNET Detail
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Statistical analyses assessing the joint effect of H. pylori infection and the selected polymorphism... DisGeNET Detail
We conclude that TLR10 is a functional receptor involved in the innate immune response to H. pylori ... DisGeNET Detail
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This study examined the role of TLR2 and 4 in regulating inflammation and endothelial dysfunction wh... DisGeNET Detail
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High mobility group box 1 (HMGB1), a recently discovered potent pro-inflammatory cytokine, plays an ... DisGeNET Detail
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Collectively, our results suggest that targeting the signalling pathway of TLR2 and 4 may be of ther... DisGeNET Detail
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Our aim is to study a transcriptional activation pathway of the innate immune system through the cel... DisGeNET Detail
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The effect of genetic polymorphisms of TLR2 and TLR4 in Turkish patients with coronary artery diseas... DisGeNET Detail
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TLR2 down regulation in wounds of T2DM patients compared to non diabetic patients may lead to develo... DisGeNET Detail
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Down-regulation of miR-144 elicits proinflammatory cytokine production by targeting toll-like recept... DisGeNET Detail
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Effect of lornoxicam therapy on expression of TLR2 and TLR4 mRNA during systemic complications of ac... DisGeNET Detail
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Our results show that rheumatoid arthritis synovial fibroblasts (RASF) express a series of TLRs, inc... DisGeNET Detail
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NA DisGeNET Detail
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TLR2 and TLR4 in autoimmune diseases: a comprehensive review. DisGeNET Detail
TLR2, a PRR, recognizes exogenous PAMPs, and endogenous damage-associated molecular patterns and has... DisGeNET Detail
NA DisGeNET Detail
Moreover, we observed that expression of TLR2 and TLR4 was significantly higher in patients with AML... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
The role of TLR2 and 4 in Behçet's disease pathogenesis. DisGeNET Detail
Combined effect of TLR2 gene polymorphism and early life stress on the age at onset of bipolar disor... DisGeNET Detail
NA DisGeNET Detail
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Expression of TLR2 and TLR4 receptor proteins on colon cancer cells were confirmed by immunohistoche... DisGeNET Detail
TLR 2, 4, 5, 7 and 9 appear to reflect certain clinicopathological variables and prognostic markers ... DisGeNET Detail
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Overlapped Transcript Coordinates

Gene Transcript ID Exon Number Chromosome Start Stop Type Amino Mutation Transcript Position Links

Overlapped Transcript

Gene Transcript ID Chromosome Start Stop Links
Gene
-
dbSNP
rs386502799 dbSNP
Genome
hg38
Position
chr4:153,684,050-153,706,260
Variant Type
snv
Genome browser