syphilis
Information
- Disease name
- syphilis
- Disease ID
- DOID:4166
- Description
- "A primary bacterial infectious disease that is a sexually transmitted systemic disease, has_material_basis_in Treponema pallidum subsp pallidum, which is transmitted_by sexual contact, transmitted_by blood product transfusion, transmitted_by congenital method from mother to fetus or transmitted_by contact with infectious lesions. If left untreated, produces chancres, rashes, and systemic lesions in a clinical course with three stages continued over many years." [url:http\://en.wikipedia.org/wiki/Syphilis, url:http\://www2.merriam-webster.com/cgi-bin/mwmednlm?book=Medical&va=syphilis]
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
| Genes | Mutation | Description | Source | Links |
|---|
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT03310424 | Active, not recruiting | Transcriptomic and Next Generation Sequencing Approaches to Infection With Treponema Pallidum | October 27, 2017 | August 2024 | |
| NCT06367621 | Active, not recruiting | Retrospective Study of iStatis Syphilis Ab Test (POC) | November 15, 2023 | April 15, 2024 | |
| NCT05541081 | Active, not recruiting | N/A | Investigating Point-of-care Diagnostics for Sexually Transmitted Infections and Antimicrobial Resistance in Primary Care in Zimbabwe | January 12, 2023 | April 2024 |
| NCT04947475 | Active, not recruiting | N/A | Project MATLINK: Development and Evaluation of a Screening, Brief Intervention, & Referral to Treatment (SBIRT) Program for Opioid Dependent Prisoners and Probationers Transitioning to the Community | January 1, 2017 | July 31, 2024 |
| NCT03980223 | Active, not recruiting | Phase 4 | Evaluation of Doxycycline Post-exposure Prophylaxis to Reduce Sexually Transmitted Infections in PrEP Users and HIV-infected Men Who Have Sex With Men | November 26, 2019 | May 13, 2023 |
| NCT02864550 | Active, not recruiting | Phase 4 | Oral Doxycycline for the Prevention of Syphilis in Men Who Have Sex With Men (DaDHS) | August 15, 2019 | December 31, 2024 |
| NCT00279331 | Completed | Estimating the Incidence of HIV Infection Among Men Who Have Sex With Men in Peru and Ecuador | November 2006 | ||
| NCT00300534 | Completed | N/A | Multi-site Study of Rapid Diagnostic Syphilis Assays | August 2002 | July 2009 |
| NCT00425984 | Completed | Phase 3 | Male Circumcision for HIV Prevention in Rakai, Uganda | August 2002 | December 2006 |
| NCT00552539 | Completed | N/A | Syphilis Video Tool to Promote Knowledge and Testing in the ED | June 2006 | August 2006 |
| NCT00553111 | Completed | N/A | Video Tool to Promote Knowledge of Syphilis as Facilitator of HIV Transmission | November 2006 | April 2007 |
| NCT00023582 | Completed | HIV and Genital Herpes Among High-Risk Men Who Have Sex With Men (MSM) in Lima, Peru | |||
| NCT01439503 | Completed | Phase 2 | Safer Sex Program for Young African-American Men | September 2012 | April 2, 2018 |
| NCT01465607 | Completed | N/A | Implementation of an Efficacious Intervention for High Risk Women in Mexico | November 2011 | April 2015 |
| NCT01530672 | Completed | N/A | Evaluation of the MBio Combined Syphilis/HIV Point-of-Care Diagnostic Test | January 2012 | September 2013 |
| NCT01317784 | Completed | N/A | Behavioral Science Aspects of Rapid Test Acceptance | May 2011 | August 2014 |
| NCT00031499 | Completed | Phase 3 | Azithromycin/Bicillin Syphilis | June 2000 | March 2009 |
| NCT00207506 | Completed | Phase 1/Phase 2 | Lay Health Advisors for Sexually Transmitted Disease Prevention | October 2004 | October 2007 |
| NCT00213018 | Completed | Phase 2 | Safety, Acceptability and Preliminary Effectiveness of Carraguard™ (PC-515) in Preventing HIV/STI Transmission | October 1999 | January 2002 |
| NCT00213031 | Completed | Phase 2 | Safety, Acceptability and Preliminary Effectiveness of PC-515 for Vaginal Use as a Possible Microbicide | February 2000 | December 2001 |
| NCT00213057 | Completed | Phase 1 | Safety and Acceptability of Carraguard™ Among HIV-negative Couples in Thailand | June 2001 | June 2002 |
| NCT02019043 | Completed | N/A | Evaluation of Enhanced Syphilis Screening Among HIV-positive Men | February 1, 2015 | July 31, 2017 |
| NCT02031146 | Completed | N/A | Lumbar Puncture and Syphilis Outcome | August 2013 | December 2020 |
| NCT02059525 | Completed | Treponema Pallidum-specific Proteomic Changes in Patients With Incident Syphilis Infection | July 2014 | November 15, 2017 | |
| NCT02122094 | Completed | N/A | Implementation of a Sexual Health Intervention for Young Men Who Have Sex With Men (MSM) in Two Vietnamese Cities | May 2013 | September 2016 |
| NCT02191527 | Completed | N/A | Evaluating the Effectiveness of Point-of-care Diagnostic Technologies in MCH Services in Mozambique | September 2013 | February 2015 |
| NCT02257658 | Completed | N/A | Efficacy of Doxycycline Prophylaxis to Reduce Syphilis in High-Risk, HIV-Positive MSM | September 2011 | January 2013 |
| NCT02445846 | Completed | Dual Rapid HIV & Syphilis Tests in Zambia | May 2014 | January 2016 | |
| NCT02447484 | Completed | N/A | Texting Intervention to Sustain HIV Prevention in Women in High-drug-use Contexts | July 1, 2015 | August 2021 |
| NCT02454816 | Completed | N/A | Introduction Study of Dual HIV & Syphilis Rapid Diagnostic Tests in Antenatal Clinics in Colombia | May 2014 | April 2015 |
| NCT02611765 | Completed | Phase 4 | Syphilis Response to Higher Penicillin Dosage: The 2.4 Versus 7.2 Study | September 2008 | April 2012 |
| NCT03637660 | Completed | Phase 4 | Phase 4 Comparative Trial of Benzathine Penicillin G for Treatment of Early Syphilis in Subjects With or Without HIV Infection | October 31, 2018 | March 20, 2023 |
| NCT03660488 | Completed | Phase 2 | Cefixime for Alternative Syphilis Treatment | September 3, 2018 | January 30, 2021 |
| NCT03709862 | Completed | Global Syphilis Sequencing | October 8, 2018 | February 28, 2022 | |
| NCT04325555 | Completed | Pre-exposure Prophylaxis: A Miracle Drug or a Moral Hazard | January 20, 2020 | March 15, 2020 | |
| NCT04480749 | Completed | Phase 4 | Syphilis Self-testing to Expand Test Uptake Among Men Who Have Sex With Men (SST) | October 14, 2020 | December 31, 2021 |
| NCT04514848 | Completed | N/A | Point of Care Tests for Syphilis and HIV | July 27, 2020 | February 14, 2022 |
| NCT04782739 | Completed | Impact of COVID-19 on Provision and Uptake of Prevention of Mother-to-child Transmission of HIV Services in Zimbabwe | March 15, 2021 | December 31, 2022 | |
| NCT05307991 | Completed | Integrating Enhanced HIV PrEP Into a STI Clinic in Lilongwe | March 9, 2022 | August 1, 2023 | |
| NCT05951751 | Not yet recruiting | N/A | The TRIple Elimination Model Of Mother-to-child Transmission Program (TRI-MOM) | September 2023 | May 2025 |
| NCT06188442 | Not yet recruiting | Phase 4 | Superiority of On-demand PrEP Versus PEP on Using Doxycycline for Preventing STI in MSM | April 2024 | March 2027 |
| NCT06058286 | Not yet recruiting | N/A | MENJAGA: Continuous Quality Improvement for Antenatal HIV, Syphilis and Hepatitis B Testing in Indonesia | October 1, 2023 | December 31, 2024 |
| NCT06428643 | Not yet recruiting | N/A | A Seek, Test, and Treat Intervention to Reduce Chlamydia Trachomatis Disparities | September 1, 2024 | September 1, 2029 |
| NCT06365606 | Recruiting | N/A | Study to Evaluate Diagnostic Sensitivity and Specificity of iStatis Syphilis Ab Test at the Point- Of-Care Sites | March 14, 2024 | May 29, 2024 |
| NCT06059443 | Recruiting | N/A | mLab App Plus: A Randomized Controlled Trial of a Mobile Health (mHealth) Intervention | October 17, 2023 | September 24, 2024 |
| NCT06100250 | Recruiting | N/A | Zenyth: Motivational Interviewing-based Telehealth Intervention for Bacterial Sexually Transmitted Infection Screening | April 19, 2024 | January 31, 2025 |
| NCT04084379 | Recruiting | Implementation Strategy of Bio-molecular Techniques for Early Diagnose of Congenital Syphilis and Chagas Diseases | July 1, 2019 | September 1, 2024 | |
| NCT06187064 | Recruiting | N/A | Combination Primary Care and Prevention Services for Women Who Inject Drugs and Exchange Sex in Seattle, Washington | March 18, 2024 | June 2025 |
| NCT04793750 | Recruiting | N/A | Ending the HIV Epidemic Through Point-of-Care Technologies (EHPOC) | August 18, 2021 | August 2025 |
| NCT04838717 | Recruiting | Phase 3 | Clinical Trial of Doxycycline VS BPG for Early Syphilis (SY-DOXY) | December 6, 2021 | December 2023 |
| NCT04958122 | Recruiting | Phase 3 | Cefixime Clinical Trial | June 20, 2021 | June 30, 2025 |
| NCT05326061 | Recruiting | Vienna HIV Infection Via Sex Study | July 1, 2020 | December 2030 | |
| NCT05548426 | Recruiting | Phase 2 | Linezolid for Syphilis Pilot Study | September 28, 2023 | March 2025 |
| NCT05831098 | Recruiting | N/A | Evaluation of the Sensitivity, Specificity, and Utility of the Reveal® TP (Syphilis) Antibody POCT | May 12, 2023 | April 2024 |
| NCT05863117 | Recruiting | N/A | Syphilis and HIV Point of Care Testing (POCT) in Saskatchewan | February 1, 2023 | July 2024 |
| NCT06082453 | Recruiting | N/A | Modernizing Perinatal Syphilis Testing | May 2, 2023 | November 30, 2027 |
| NCT01540227 | Terminated | Penicillin Therapeutic Drug Monitoring in the Treatment of Infectious Syphilis. | September 2011 | November 10, 2016 | |
| NCT02871505 | Unknown status | Phase 4 | The Association Between Molecular Typing of Treponema Pallidum and Treatment Efficacy and Clinical Findings | August 2016 | August 2020 |
| NCT02884115 | Unknown status | Phase 4 | Serological Response to Retreatment of Serofast Early Syphilis Cases With Benzathine Penicillin | August 2016 | September 2020 |
| NCT01315054 | Unknown status | N/A | A Methadone Maintenance Treatment Outcome Study in Three Provinces in China | May 2011 | December 2014 |
| NCT01300689 | Unknown status | Human Papillomavirus Infection and Knowledge and Attitudes About HPV Vaccines Among Men Who Have Sex With Men (MSM) | July 2011 | ||
| NCT00124878 | Unknown status | Phase 3 | Trial of Male Circumcision: HIV, Sexually Transmitted Disease (STD) and Behavioral Effects in Men, Women and the Community | August 2003 | September 2009 |
| NCT01068015 | Unknown status | Phase 3 | (Men Who Have Sex With Men) MSM Community Intervention Trial | June 2009 | December 2010 |
| NCT02844634 | Unknown status | Phase 4 | Tenofovir/Emtricitabine With Doxycycline for Combination HIV and Syphilis Pre-exposure Prophylaxis in HIV-negative MSM | May 15, 2018 | June 30, 2020 |
| NCT01108614 | Unknown status | Phase 3 | Injecting Drug Use Community Intervention Trial | June 2009 | March 2011 |
| NCT02857959 | Unknown status | Phase 4 | One Dose Versus Three Weekly Doses of Benzathine Penicillin G for Patients With Early Syphilis | August 2016 | August 2020 |
| NCT04753125 | Unknown status | N/A | Interventions for Enhancing Adherence to Syphilis Treatment and Follow-up: Study Protocol for the Health Information and Monitoring of Sexually Transmitted Infections (SIM) Randomized Controlled Trial | April 2021 | July 2023 |
| NCT03754517 | Unknown status | Finding the Latent Treponema Pallidum | August 2016 | December 2019 | |
| NCT01543295 | Withdrawn | Evaluation of the Performance of Chembio's DPP(R) Syphilis Screen & Confirm Rapid Test System | July 2011 | December 2012 |
- Disase is a (Disease Ontology)
- DOID:0050338
- Cross Reference ID (Disease Ontology)
- ICD10CM:A51.0
- Cross Reference ID (Disease Ontology)
- MESH:D002601
- Cross Reference ID (Disease Ontology)
- SNOMEDCT_US_2023_03_01:736686006
- Cross Reference ID (Disease Ontology)
- UMLS_CUI:C0007939
- Exact Synonym (Disease Ontology)
- syphilitic chancre
- MeSH unique ID (MeSH (Medical Subject Headings))
- D013587