Annotation Detail
Information
- Associated Genes
- TLR2
- Associated Variants
-
TLR2 MUTATION
TLR2 MUTATION - Associated Disease
- Hypertensive disease
- Source Database
- DisGeNET
- Description
- Candesartan cilexetil, a drug approved for treating hypertension and that inhibits the expression of TLR2, reversed the activated proinflammatory phenotype of primary microglia exposed to oligomeric α-synuclein, supporting the possibility of repurposing this drug for synucleinopathies.
- Pubmed
- 25969543
- Section of the abstract supporting the evidence
- ALL_TEXT_3/3
- Number of the section of the abstract supporting the evidence
- 3
- Number of the sentence supporting the evidence
- 5
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.00108576748832121
Drugs