chr17:42313324:> Detail (hg38)

Information

Genome

Assembly Position
hg19 chr17:40,465,342-40,540,586 
hg38 chr17:42,313,324-42,388,568

HGVS

Type Transcript Protein
Summary

MGeND

Clinical significance
Variant entry
GWAS entry
Disease area statistics Show details

Frequency

[No Data.]

Prediction

[No Data.]

ClinVar

Clinical Significance
Review star [No Data.]
Show details
Links
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
[No Data.]
CIViC
[No Data.]
DisGeNET
Score Disease name Description Source Pubmed Links
0.142 squamous cell carcinoma Here we show a clear correlation between the efficacy of anti-EGFR inhibitors wi... BeFree,CTD_human,LHGDN 24556630 Detail
<0.001 Carcinoma, Transitional Cell High NF-κB and STAT3 activity in human urothelial carcinoma: a pilot study. BeFree 24448750 Detail
<0.001 Cardiomyopathy, Dilated NA BeFree Detail
0.005 Cardiovascular Diseases NA BeFree,GAD,LHGDN Detail
0.120 brain ischemia NA CTD_human Detail
0.080 Transient ischemic attack NA RGD Detail
0.002 Malignant tumor of cervix miR-21 and Let-7a along with STAT3 may prove useful targets for pharmacological ... BeFree 25539644 Detail
0.002 Malignant tumor of cervix These results suggest that polymorphisms in STAT2, STAT3 and IFN-γ genes are not... BeFree 25921106 Detail
<0.001 Cervical dysplasia NA BeFree Detail
0.120 Uterine Cervical Neoplasm GRIM‑19‑mediated Stat3 activation is a determinant for resveratrol‑induced proli... BeFree,CTD_human 25351437 Detail
0.003 cheilitis NA LHGDN Detail
<0.001 Primary biliary cirrhosis NA BeFree Detail
<0.001 cholesteatoma NA BeFree Detail
<0.001 chordoma NA BeFree Detail
0.007 choriocarcinoma NA BeFree,LHGDN Detail
0.004 colitis Butein effects in colitis and interleukin-6/signal transducer and activator of t... BeFree 25593461 Detail
0.126 Colonic Neoplasms NA BeFree,CTD_human,LHGDN Detail
0.010 colorectal carcinoma Overall, this study suggests that PKM2 overexpression promotes CRC cell migratio... BeFree 24686087 Detail
0.010 colorectal carcinoma Using a unique systems biology approach, we identified JAK1/2-dependent activati... BeFree 24931611 Detail
0.010 colorectal carcinoma Genome-wide uncovering of STAT3-mediated miRNA expression profiles in colorectal... BeFree 25126546 Detail
0.010 colorectal carcinoma Therefore, miR-27a could be a useful biomarker for monitoring colorectal cancer ... BeFree 25166914 Detail
0.010 colorectal carcinoma Th17-type cytokines, IL-6 and TNF-α synergistically activate STAT3 and NF-kB to ... BeFree 25174402 Detail
0.010 colorectal carcinoma This suggests that STAT3 positively regulates β-catenin (at a transcriptional le... BeFree 25348333 Detail
0.010 colorectal carcinoma Inhibition of STAT3/cyclinD1 pathway increased the sensitivity of colorectal can... BeFree 25617735 Detail
0.010 colorectal carcinoma Aberrantly expressed Fra-1 by IL-6/STAT3 transactivation promotes colorectal can... BeFree 25750173 Detail
0.014 Colorectal Neoplasms NA BeFree,LHGDN Detail
<0.001 Coronary Arteriosclerosis NA BeFree Detail
<0.001 cystic fibrosis NA BeFree Detail
<0.001 Cytomegalovirus Infections NA BeFree Detail
0.003 Mental Depression STAT3 controls IL6-dependent regulation of serotonin transporter function and de... BeFree,GAD 25760924 Detail
<0.001 depressive disorder STAT3 controls IL6-dependent regulation of serotonin transporter function and de... BeFree 25760924 Detail
0.003 Dermatitis, Atopic Topical application of the JAK inhibitor suppressed STAT3 activation and improve... BeFree,GAD 26115905 Detail
<0.001 Diabetes NA BeFree Detail
<0.001 diabetes mellitus NA BeFree Detail
0.080 Diabetes Mellitus, Experimental NA RGD Detail
0.122 Diabetes Mellitus, Insulin-Dependent NA CTD_human,GAD Detail
<0.001 Diabetes Mellitus, Non-Insulin-Dependent NA BeFree Detail
0.080 Diabetic Nephropathy NA BeFree,RGD Detail
<0.001 diarrhea NA BeFree Detail
0.002 DNA Damage NA GAD Detail
<0.001 Down syndrome NA BeFree Detail
0.080 duodenal ulcer NA RGD Detail
<0.001 Amebic colitis NA BeFree Detail
0.002 Eczema Topical application of the JAK inhibitor suppressed STAT3 activation and improve... BeFree 26115905 Detail
<0.001 encephalitis NA BeFree Detail
0.001 Experimental Autoimmune Encephalomyelitis In addition to the in vitro inhibition of human Th17 cells in a dose-dependent m... BeFree 25263529 Detail
<0.001 endometriosis Enhanced miR-210 expression promotes the pathogenesis of endometriosis through a... BeFree 25516558 Detail
<0.001 endometriosis Cross-sectional measurements of STAT3 and HIF1A protein levels in eutopic endome... BeFree 25750101 Detail
0.001 Esophageal Neoplasms AURKA regulates JAK2-STAT3 activity in human gastric and esophageal cancers. BeFree 24953013 Detail
0.003 Fatty Liver NA BeFree,GAD Detail
0.123 Fibrosis NA CTD_human,LHGDN Detail
0.001 gastritis Inhibition of Jak1/Stat3 may be beneficial for the treatment of H. pylori-induce... BeFree 25837197 Detail
0.018 glioblastoma Blocking the bFGF/STAT3 interaction through specific signaling pathways induces ... BeFree,LHGDN 25048528 Detail
0.018 glioblastoma RRAD promotes EGFR-mediated STAT3 activation and induces temozolomide resistance... BeFree,LHGDN 25313011 Detail
0.018 glioblastoma FoxM1 Drives a Feed-Forward STAT3-Activation Signaling Loop That Promotes the Se... BeFree,LHGDN 25832656 Detail
0.018 glioblastoma Ceacam1L Modulates STAT3 Signaling to Control the Proliferation of Glioblastoma-... BeFree,LHGDN 26238781 Detail
0.014 Glioma IL-1 also activated Stat3, a transcription factor crucial in glioma progression. BeFree,LHGDN 25054228 Detail
0.014 Glioma TRPM7 channels regulate glioma stem cell through STAT3 and Notch signaling pathw... BeFree,LHGDN 25192910 Detail
0.014 Glioma Furthermore, the suppression of IRG1 expression inhibited the expression of NF-κ... BeFree,LHGDN 25216059 Detail
0.014 Glioma Suppression of autophagy augments the radiosensitizing effects of STAT3 inhibiti... BeFree,LHGDN 25220423 Detail
0.014 Glioma These data suggest that aberrant activation of STAT-3, which is observed in mali... BeFree,LHGDN 25246098 Detail
0.014 Glioma Furthermore, we revealed that STAT3 was required to maintain SCLIP stability, su... BeFree,LHGDN 25511414 Detail
0.014 Glioma Collectively, our findings showed how FoxM1 activates expression of PDGF-A and S... BeFree,LHGDN 25832656 Detail
0.014 Glioma STAT3 Blockade Inhibits Radiation-Induced Malignant Progression in Glioma. BeFree,LHGDN 26282165 Detail
0.003 glomerulonephritis NA LHGDN Detail
<0.001 Graves Disease NA BeFree Detail
0.003 Head and Neck Neoplasms NA LHGDN Detail
0.080 Heart Diseases NA RGD Detail
0.120 Cardiomegaly NA CTD_human Detail
0.001 Heart failure NA BeFree Detail
0.001 congestive heart failure NA BeFree Detail
<0.001 hemangioma Moreover, the protein levels of VEGF, phosphorylated STAT3, total STAT3 and Bcl-... BeFree 25872592 Detail
<0.001 hepatitis NA BeFree Detail
<0.001 hepatitis A NA BeFree Detail
<0.001 hepatitis B NA BeFree Detail
0.120 Hepatitis, Chronic NA CTD_human Detail
0.010 hepatitis C Hepatitis C virus represses the cellular antiviral response by upregulating the ... BeFree,GAD,LHGDN 25377467 Detail
<0.001 Herpes Simplex Infections We found that, like two other herpesviruses, EBV and HSV-1, KSHV exploits the ce... BeFree 26339061 Detail
<0.001 Herpesviridae Infections NA BeFree Detail
0.002 HIV Infections NA BeFree Detail
0.006 Hodgkin Disease NA BeFree,LHGDN Detail
<0.001 Huntington disease The JAK/STAT3 pathway is a common inducer of astrocyte reactivity in Alzheimer's... BeFree 25673868 Detail
<0.001 Hydatidiform mole NA BeFree Detail
0.080 Hyperalgesia NA RGD Detail
<0.001 hyperinsulinism NA BeFree Detail
<0.001 pulmonary hypertension NA BeFree Detail
<0.001 Ileal Diseases NA BeFree Detail
<0.001 Immunologic Deficiency Syndromes NA BeFree Detail
<0.001 Immune System Diseases NA BeFree Detail
0.120 Inflammation NA CTD_human Detail
0.129 Inflammatory Bowel Diseases These data suggest that the STAT3 locus is associated with both IBD and cancer. BeFree,GAD,GWASCAT,LHGDN 25132422 Detail
0.129 Inflammatory Bowel Diseases Therefore, mTORC1 signaling critically protects against inflammatory bowel disea... BeFree,GAD,GWASCAT,LHGDN 26026060 Detail
0.005 Insulin resistance NA GAD Detail
<0.001 Intestinal Diseases Recently, mutations in STAT1, STAT5B, and STAT3 have been linked to development ... BeFree 25349174 Detail
0.004 ischemia NA BeFree,LHGDN Detail
0.003 Keloid NA BeFree,LHGDN Detail
0.003 Kidney Diseases NA BeFree,LHGDN Detail
<0.001 Kidney Failure, Chronic NA BeFree Detail
<0.001 Polycystic Kidney Diseases NA BeFree Detail
<0.001 Laryngeal neoplasm NA BeFree Detail
<0.001 leiomyosarcoma NA BeFree Detail
0.009 leukemia Here, we report the characterization of STAT3 protein regulation by STAT3-intera... BeFree,LHGDN 25417721 Detail
0.004 chronic lymphocytic leukemia STAT3-activated GM-CSFRα translocates to the nucleus and protects CLL cells from... BeFree 24836891 Detail
0.004 chronic lymphocytic leukemia Furthermore, STAT3 activity contributes to the resistance to apoptosis of CLL, b... BeFree 25299776 Detail
0.004 chronic lymphocytic leukemia IL-6, IL-10, c-Jun and STAT3 expression in B-CLL. BeFree 25477266 Detail
0.003 Acute Erythroblastic Leukemia NA BeFree,LHGDN Detail
<0.001 Acute lymphocytic leukemia NA BeFree Detail
0.128 Leukemia, Myelocytic, Acute STAT3 as a possible therapeutic target in human malignancies: lessons from acute... BeFree,CTD_human,LHGDN 25374305 Detail
0.003 myeloid leukemia NA BeFree,GAD Detail
0.005 Myeloid Leukemia, Chronic Combined STAT3 and BCR-ABL1 inhibition induces synthetic lethality in therapy-re... BeFree,LHGDN 25134459 Detail
0.005 Myeloid Leukemia, Chronic Inhibition of STAT3-interacting protein 1 (STATIP1) promotes STAT3 transcription... BeFree,LHGDN 25417721 Detail
0.120 Precursor B-Cell Lymphoblastic Leukemia-Lymphoma NA CTD_human Detail
<0.001 prolymphocytic leukemia In the present study, Poly I:C (PIC, a TLR3 agonist), STAT3 siRNA and OVA antige... BeFree 25457983 Detail
<0.001 acute promyelocytic leukemia NA BeFree Detail
0.121 Leukemia, T-Cell NA BeFree,CTD_human Detail
0.120 Adult T-Cell Lymphoma/Leukemia NA BeFree,CTD_human Detail
<0.001 leukopenia NA BeFree Detail
0.004 liver cirrhosis NA BeFree,LHGDN Detail
0.006 Liver Cirrhosis, Alcoholic NA BeFree,LHGDN Detail
0.003 Biliary cirrhosis NA LHGDN Detail
<0.001 Alcoholic Liver Diseases NA BeFree Detail
0.124 Liver neoplasms Effects of mTOR-STAT3 on the migration and invasion abilities of hepatoma cell a... BeFree,CTD_human 25063062 Detail
0.124 Liver neoplasms Antitumor progression potential of morusin suppressing STAT3 and NFκB in human h... BeFree,CTD_human 25476160 Detail
0.124 Liver neoplasms These results indicate that PML modulates IL-6-induced STAT3 activation and hepa... BeFree,CTD_human 25892518 Detail
<0.001 Lown-Ganong-Levine syndrome NA BeFree Detail
0.003 Lung diseases NA LHGDN Detail
0.001 Chronic Obstructive Airway Disease Liuweibuqi capsules can improve the symptoms of COPD possibly by regulating the ... BeFree 25842729 Detail
0.010 Lung Neoplasms Consistently, KRAS mutant lung tumours exhibit reduced STAT3 levels. BeFree,LHGDN 25734337 Detail
<0.001 Lupus Vulgaris Stat3 promotes IL-10 expression in lupus T cells through trans-activation and ch... BeFree 25187566 Detail
<0.001 Lupus Erythematosus, Discoid Stat3 promotes IL-10 expression in lupus T cells through trans-activation and ch... BeFree 25187566 Detail
0.001 Lupus Erythematosus, Systemic However, this deficit was not primarily at the signaling or the transcriptional ... BeFree 25101889 Detail
0.001 Lupus Erythematosus, Systemic Stat3 promotes IL-10 expression in lupus T cells through trans-activation and ch... BeFree 25187566 Detail
<0.001 lupus nephritis NA BeFree Detail
0.120 Lymphatic Metastasis NA CTD_human Detail
<0.001 Lymphohistiocytosis, Hemophagocytic NA BeFree Detail
0.023 lymphoma Activating mutations of STAT5B and STAT3 in lymphomas derived from γδ-T or NK ce... BeFree,LHGDN 25586472 Detail
0.023 lymphoma Effect of STAT3 inhibition on the metabolic switch in a highly STAT3-activated l... BeFree,LHGDN 25977172 Detail
<0.001 Lymphoma, Follicular NA BeFree Detail
0.003 Lymphoma, Non-Hodgkin ChIP, Co-IP and ChIP-re-IP analysis revealed that ISL-1 could participate with p... BeFree,GAD 25070240 Detail
0.003 Lymphoma, Non-Hodgkin Minor salivary glands (MSGs) from patients with pSS and non-specific chronic sia... BeFree,GAD 25880879 Detail
<0.001 lymphopenia NA BeFree Detail
<0.001 Lymphoproliferative Disorders NA BeFree Detail
0.011 Malignant neoplasm of stomach Silibinin inhibits proliferation, induces apoptosis and causes cell cycle arrest... BeFree 25169527 Detail
0.011 Malignant neoplasm of stomach Piperine inhibits IL-1β-induced IL-6 expression by suppressing p38 MAPK and STAT... BeFree 25234193 Detail
0.011 Malignant neoplasm of stomach Combinatorial targeting on both HER2 and STAT3 may enhance the efficacy of trast... BeFree 25327561 Detail
0.011 Malignant neoplasm of stomach Correlation of RKIP, STAT3 and cyclin D1 expression in pathogenesis of gastric c... BeFree 25337233 Detail
0.011 Malignant neoplasm of stomach Taken together, these findings indicate that down-regulation of miR-874 contribu... BeFree 25596740 Detail
0.011 Malignant neoplasm of stomach Thus, dual use of STAT3 and GSK-3β inhibitors may enhance the efficacy of the an... BeFree 25846563 Detail
0.120 Animal Mammary Neoplasms NA CTD_human Detail
0.120 Mammary Neoplasms, Experimental NA CTD_human Detail
<0.001 mastocytosis NA BeFree Detail
0.125 medulloblastoma Taken together, these findings indicate LY5 inhibits persistent and inducible ST... BeFree,CTD_human,LHGDN 25313399 Detail
0.012 melanoma Critical role of STAT3 in melanoma metastasis through anoikis resistance. BeFree,LHGDN 25216522 Detail
0.012 melanoma FAD104 interacted with STAT3 and down-regulated the phosphorylation level of STA... BeFree,LHGDN 25671570 Detail
0.120 Memory Disorders NA CTD_human Detail
<0.001 multiple endocrine neoplasia type 2B NA BeFree Detail
0.001 meningioma NA BeFree Detail
0.003 Mesothelioma STAT3 downregulation with siRNA or enhanced expression of PIAS3 both inhibited m... BeFree,LHGDN 25124686 Detail
<0.001 Metabolic Diseases Here we explore whether STAT3 common variations influence risks of obesity and o... BeFree 25014397 Detail
<0.001 Mixed Salivary Gland Tumor Using immunohistochemistry, IL-6, JAK1, JAK2 and STAT3 were detected significant... BeFree 26061266 Detail
<0.001 Monosomy NA BeFree Detail
0.021 multiple myeloma Down-regulation of interleukin 6 (IL6) by berberine might lead to inhibition of ... BeFree,LHGDN 25000828 Detail
0.021 multiple myeloma Evaluation of human MM samples revealed recurrent activation of STAT3, a downstr... BeFree,LHGDN 25384216 Detail
0.128 multiple sclerosis NA BeFree,GAD,GWASCAT Detail
<0.001 muscular atrophy NA BeFree Detail
0.001 Mycobacterium Infections Autoimmunity, hypogammaglobulinemia, lymphoproliferation, and mycobacterial dise... BeFree 25349174 Detail
0.002 Mycoses These results demonstrate that central mediators of immune responses like STAT1 ... BeFree 23796786 Detail
0.002 Mycoses Mutations affecting the STAT3/interleukin 17 (IL-17) pathway cause selective sus... BeFree 26255980 Detail
0.003 mycosis fungoides NA BeFree,LHGDN Detail
<0.001 myelofibrosis NA BeFree Detail
<0.001 Myeloproliferative disease Our results demonstrate that JAK-STAT3-mediated cytokine production from maligna... BeFree 25572172 Detail
<0.001 myocardial infarction NA BeFree Detail
0.080 Myocardial Reperfusion Injury NA RGD Detail
<0.001 myocarditis NA BeFree Detail
<0.001 Nasal Polyps NA BeFree Detail
0.001 Neck Neoplasms NA BeFree Detail
0.148 Neoplasm Metastasis These findings identify CXCR7-mediated STAT3 activation and modulation of the tu... BeFree,CTD_human,LHGDN 24886617 Detail
0.148 Neoplasm Metastasis But the exact molecular mechanism on metastasis is still not fully understood; w... BeFree,CTD_human,LHGDN 25038455 Detail
0.148 Neoplasm Metastasis mTORSTAT3 expression in hepatoma cells HepG2 was significantly higher than that ... BeFree,CTD_human,LHGDN 25063062 Detail
0.148 Neoplasm Metastasis Critical role of STAT3 in melanoma metastasis through anoikis resistance. BeFree,CTD_human,LHGDN 25216522 Detail
0.148 Neoplasm Metastasis ACA is a novel drug candidate for the inhibition of tumor metastasis through int... BeFree,CTD_human,LHGDN 25301089 Detail
0.148 Neoplasm Metastasis Our findings suggest that activation of the JAK2/STAT3 pathway via CXCL12-CXCR4 ... BeFree,CTD_human,LHGDN 25310198 Detail
0.148 Neoplasm Metastasis Our study suggested a novel role for CD8(+) T cells in constraining myeloid cell... BeFree,CTD_human,LHGDN 25310972 Detail
0.148 Neoplasm Metastasis In conclusion, these data suggest that RKIP inhibits gastric cancer metastasis v... BeFree,CTD_human,LHGDN 25337233 Detail
0.148 Neoplasm Metastasis In conclusion, JAk2/STAT3 plays a key role in CCR7 regulating SCCHN metastasis. BeFree,CTD_human,LHGDN 25405202 Detail
0.148 Neoplasm Metastasis Taken together, our results established the critical involvement of STAT3 in con... BeFree,CTD_human,LHGDN 25411359 Detail
0.148 Neoplasm Metastasis Activated STAT3, Twist, and EMT markers may serve as potential molecular targets... BeFree,CTD_human,LHGDN 25653024 Detail
0.148 Neoplasm Metastasis Fad104, a positive regulator of adipocyte differentiation, suppresses invasion a... BeFree,CTD_human,LHGDN 25671570 Detail
0.148 Neoplasm Metastasis Cytoplasmic p27 promotes epithelial-mesenchymal transition and tumor metastasis ... BeFree,CTD_human,LHGDN 25684140 Detail
0.148 Neoplasm Metastasis The transcription factor signal transducers and activators of transcription 3 (S... BeFree,CTD_human,LHGDN 25846563 Detail
0.148 Neoplasm Metastasis In summary, our study show for the first time that STAT3 activation may induce i... BeFree,CTD_human,LHGDN 26158169 Detail
0.148 Neoplasm Metastasis Leukemia inhibitory factor promotes tumor growth and metastasis in human osteosa... BeFree,CTD_human,LHGDN 26271643 Detail
<0.001 multiple endocrine neoplasia NA BeFree Detail
0.001 nephroblastoma NA BeFree Detail
0.003 neurilemmoma NA BeFree,LHGDN Detail
0.002 neuroblastoma NA BeFree Detail
<0.001 neutropenia NA BeFree Detail
<0.001 Noonan syndrome NA BeFree Detail
0.090 obesity Association of STAT3 common variations with obesity and hypertriglyceridemia: pr... BeFree,GAD,RGD 25014397 Detail
0.090 obesity Together, our results show how targeting STAT3-G9a signaling regulates CSC plast... BeFree,GAD,RGD 25840984 Detail
<0.001 Obesity, Morbid NA BeFree Detail
<0.001 Degenerative polyarthritis NA BeFree Detail
0.002 osteosarcoma Efficacy of the FLLL32 pharmacological inhibitor in delaying OS growth suggests ... BeFree 25760445 Detail
0.002 osteosarcoma Leukemia inhibitory factor promotes tumor growth and metastasis in human osteosa... BeFree 26271643 Detail
0.008 ovarian carcinoma Altogether, our results demonstrate that targeting JAK1/STAT3, using shRNA knock... BeFree 25319391 Detail
0.008 ovarian carcinoma Ginsenoside 20(S)‑Rg3 inhibits the Warburg effect through STAT3 pathways in ovar... BeFree 25405516 Detail
0.008 ovarian carcinoma Synergistic effects of eukaryotic co-expression plasmid-based STAT3-specific siR... BeFree 25420630 Detail
0.008 ovarian carcinoma Targeted Blockade of JAK/STAT3 Signaling Inhibits Ovarian Carcinoma Growth. BeFree 25646015 Detail
0.008 ovarian carcinoma Here, we report results that may explain this outcome, based on the finding that... BeFree 25670170 Detail
0.008 ovarian carcinoma STAT3 Decoy Oligodeoxynucleotides-Loaded Solid Lipid Nanoparticles Induce Cell D... BeFree 25923701 Detail
0.134 Pancreatic Neoplasm NA BeFree,CTD_human,LHGDN Detail
<0.001 pancreatitis NA BeFree Detail
<0.001 papilloma NA BeFree Detail
<0.001 Pituitary Diseases STAT3 upregulation in pituitary somatotroph adenomas induces growth hormone hype... BeFree 25774503 Detail
<0.001 Pituitary Neoplasms Evaluation of pituitary tumors revealed that STAT3 expression was enhanced in hu... BeFree 25774503 Detail
0.004 pneumonia Induction of STAT3-Dependent CXCL5 Expression and Neutrophil Recruitment by Onco... BeFree,LHGDN 25692402 Detail
0.004 pneumonia Taken together, induction of liver STAT3-dependent gene expression programs is e... BeFree,LHGDN 26216424 Detail
<0.001 polycystic ovary syndrome NA BeFree Detail
<0.001 polycythemia vera NA BeFree Detail
<0.001 Adenomatous Polyposis Coli NA BeFree Detail
0.081 Precancerous Conditions NA BeFree,RGD Detail
<0.001 Preleukemia NA BeFree Detail
0.138 Prostatic Neoplasms NA BeFree,CTD_human,LHGDN Detail
<0.001 Protein Deficiency NA BeFree Detail
0.121 psoriasis NA BeFree,CTD_human Detail
<0.001 pulmonary emphysema NA BeFree Detail
<0.001 pulmonary valve stenosis NA BeFree Detail
<0.001 Q fever NA BeFree Detail
0.002 Rectal Fistula NA GAD Detail
<0.001 pure red-cell aplasia NA BeFree Detail
<0.001 kidney failure NA BeFree Detail
0.120 Reperfusion Injury NA CTD_human Detail
<0.001 Respiratory Distress Syndrome, Adult NA BeFree Detail
0.002 Respiratory Syncytial Virus Infections NA GAD Detail
<0.001 rheumatic heart disease We observed that STAT3 CG and GG genotypes were significantly associated with RH... BeFree 24797343 Detail
<0.001 Kaposi sarcoma Oncovirus Kaposi sarcoma herpesvirus (KSHV) represses tumor suppressor PDLIM2 to... BeFree 25681443 Detail
<0.001 Kaposi sarcoma STAT3 Regulates Lytic Activation of Kaposi's Sarcoma-Associated Herpesvirus. BeFree 26339061 Detail
<0.001 Scoliosis, unspecified NA BeFree Detail
<0.001 Seizures NA BeFree Detail
<0.001 Septicemia Collectively, these findings demonstrate that Zn deficiency enhances the acute p... BeFree 24732911 Detail
<0.001 Septicemia Interruption of macrophage-derived IL-27(p28) production by IL-10 during sepsis ... BeFree 25348624 Detail
<0.001 Septicemia Taken together, induction of liver STAT3-dependent gene expression programs is e... BeFree 26216424 Detail
<0.001 Sezary syndrome NA BeFree Detail
<0.001 Skin Neoplasms NA BeFree Detail
<0.001 Soft Tissue Neoplasms NA BeFree Detail
0.006 ankylosing spondylitis NA BeFree,GAD Detail
<0.001 Staphylococcal Infections NA BeFree Detail
0.143 Stomach Neoplasms NA BeFree,CTD_human,LHGDN Detail
<0.001 gastric ulcer RKIP, STAT3 and cyclin D1 proteins were detected by immunohistochemistry in tiss... BeFree 25337233 Detail
0.080 Subarachnoid Hemorrhage NA RGD Detail
<0.001 synovitis NA BeFree Detail
0.004 Thrombocythemia, Essential NA BeFree,LHGDN Detail
<0.001 Thyroid Diseases NA BeFree Detail
0.003 Thyroid Neoplasm NA BeFree,LHGDN Detail
<0.001 thyroiditis NA BeFree Detail
0.002 Tobacco use disorder NA GAD Detail
<0.001 trigeminal neuralgia NA BeFree Detail
<0.001 tuberculosis SOCS3 and STAT3, major controllers of the outcome of infection with Mycobacteriu... BeFree 25458989 Detail
<0.001 tuberous sclerosis Furthermore, BEX2 was also increased in the liver of a hepatic specific Pten kno... BeFree 26296882 Detail
<0.001 urticaria pigmentosa NA BeFree Detail
<0.001 uveitis NA BeFree Detail
<0.001 Uveitis, Posterior NA BeFree Detail
<0.001 Uveomeningoencephalitic Syndrome NA BeFree Detail
<0.001 Virus Diseases NA BeFree Detail
<0.001 xeroderma pigmentosum NA BeFree Detail
0.013 B-Cell Lymphomas NA BeFree,LHGDN Detail
0.004 diffuse large B-cell lymphoma Clinical implications of phosphorylated STAT3 expression in De Novo diffuse larg... BeFree 25124685 Detail
<0.001 Lymphoma, Large-Cell, Follicular NA BeFree Detail
0.122 T-Cell Lymphoma Here we report frequent activating mutations of STAT3 and STAT5B in NK/T-cell ly... BeFree,CTD_human 25586472 Detail
0.122 T-Cell Lymphoma Receptor-type tyrosine-protein phosphatase κ directly targets STAT3 activation f... BeFree,CTD_human 25612622 Detail
0.002 Lymphoma, T-Cell, Cutaneous Constitutive activation of STAT5 and STAT3 was observed in early and late stages... BeFree 25485578 Detail
<0.001 severe combined immunodeficiency STAT3 knock-down cells and PL treated cells did not form tumors as well as faile... BeFree 25216522 Detail
0.003 hepatitis E NA LHGDN Detail
<0.001 Polycystic Kidney, Autosomal Dominant NA BeFree Detail
<0.001 essential hypertension NA BeFree Detail
<0.001 Plasmacytosis NA BeFree Detail
<0.001 acute leukemia Our findings imply that the clonal landscape of large granular lymphocytic leuke... BeFree 25281507 Detail
<0.001 benign neoplasm The interleukin-6 (IL-6)/Janus kinase (JAK)/signal transducer and activator of t... BeFree 26061266 Detail
<0.001 Pancreatitis, Chronic NA BeFree Detail
<0.001 Epstein-Barr Virus Infections NA BeFree Detail
<0.001 Squamous cell carcinoma of lung In the present report we examine the status of an endogenous inhibitor of STAT3,... BeFree 25573684 Detail
<0.001 Squamous cell carcinoma of lung PARD3 Inactivation in Lung Squamous Cell Carcinomas Impairs STAT3 and Promotes M... BeFree 25833829 Detail
<0.001 Small cell carcinoma of lung NA BeFree Detail
<0.001 Primary Sj�gren's syndrome IL-22R1 expression on PBMC of pSS was functional, as its stimulation with recomb... BeFree 25880879 Detail
<0.001 renal fibrosis NA BeFree Detail
<0.001 Myocardial Ischemia NA BeFree Detail
<0.001 Cutaneous Melanoma NA BeFree Detail
<0.001 Dry skin Topical application of the JAK inhibitor suppressed STAT3 activation and improve... BeFree 26115905 Detail
0.002 Adenocarcinoma of lung (disorder) Knockdown of STAT3 in xenografted human AC cells increases tumour growth. BeFree 25734337 Detail
0.001 esophageal carcinoma AURKA regulates JAK2-STAT3 activity in human gastric and esophageal cancers. BeFree 24953013 Detail
<0.001 congenital heart disease NA BeFree Detail
<0.001 Idiopathic pulmonary hypertension NA BeFree Detail
<0.001 Malignant neoplasm of nasopharynx NA BeFree Detail
<0.001 Malignant neoplasm of brain We have reported that basic fibroblast growth factor (bFGF) demonstrates an inti... BeFree 25048528 Detail
<0.001 Malignant neoplasm of brain These data suggest that aberrant activation of STAT-3, which is observed in mali... BeFree 25246098 Detail
0.002 Secondary malignant neoplasm of lung NA BeFree Detail
<0.001 Secondary malignant neoplasm of bone NA BeFree Detail
<0.001 allergic asthma NA BeFree Detail
<0.001 Neonatal diabetes mellitus For neonatal diabetes, the use of these technologies has resulted in the identif... BeFree 26210631 Detail
<0.001 adrenoleukodystrophy NA BeFree Detail
<0.001 Intestinal infectious disease (disorder) NA BeFree Detail
<0.001 Autoimmune thyroid disease NA BeFree Detail
<0.001 Anaplastic carcinoma NA BeFree Detail
<0.001 Undifferentiated carcinoma NA BeFree Detail
<0.001 Carcinomatosis NA BeFree Detail
<0.001 Dysplastic Nevus NA BeFree Detail
0.129 Ki-1+ Anaplastic Large Cell Lymphoma Convergent mutations and kinase fusions lead to oncogenic STAT3 activation in an... BeFree,CTD_human,LHGDN 25873174 Detail
<0.001 hepatocellular adenoma NA BeFree Detail
0.004 cholangiocarcinoma We have characterized a novel immunosuppressant, which shows potential anti-tumo... BeFree,LHGDN 25344679 Detail
<0.001 Metastatic malignant neoplasm to brain NA BeFree Detail
0.011 pancreatic carcinoma STAT3 induces anoikis resistance, promotes cell invasion and metastatic potentia... BeFree 25411359 Detail
0.011 pancreatic carcinoma MiR-1181 inhibits stem cell-like phenotypes and suppresses SOX2 and STAT3 in hum... BeFree 25444909 Detail
0.011 pancreatic carcinoma Thus, inhibition of HIF-1α and Stat3 is a potential therapeutic strategy for pan... BeFree 25655308 Detail
0.011 pancreatic carcinoma Collectively, our results provide the first evidence for the presence of the syn... BeFree 25779676 Detail
<0.001 Gastrointestinal Stromal Tumors NA BeFree Detail
<0.001 Cancer of Nasopharynx NA BeFree Detail
<0.001 Anaplastic thyroid carcinoma NA BeFree Detail
<0.001 Medullary carcinoma of thyroid NA BeFree Detail
<0.001 Papillary thyroid carcinoma NA BeFree Detail
<0.001 bone destruction NA BeFree Detail
<0.001 Fibrosis, Liver NA BeFree Detail
<0.001 secondary myelofibrosis NA BeFree Detail
0.011 Malignant neoplasm of lung PS2 knockout mice and PS2 knockdown lung cancer cells showed increased DNA-bindi... BeFree 24858037 Detail
0.011 Malignant neoplasm of lung IL6 signaling was blocked with antibodies against IL6, soluble glycoprotein 130 ... BeFree 25461668 Detail
0.011 Malignant neoplasm of lung STAT3 is considered to play an oncogenic role in several malignancies including ... BeFree 25734337 Detail
<0.001 age related macular degeneration NA BeFree Detail
0.003 Disease Progression NA LHGDN Detail
0.081 Sepsis Collectively, these findings demonstrate that Zn deficiency enhances the acute p... BeFree,RGD 24732911 Detail
0.081 Sepsis Interruption of macrophage-derived IL-27(p28) production by IL-10 during sepsis ... BeFree,RGD 25348624 Detail
0.081 Sepsis Taken together, induction of liver STAT3-dependent gene expression programs is e... BeFree,RGD 26216424 Detail
<0.001 Multiple tumors NA BeFree Detail
<0.001 Epithelial hyperplasia of skin NA BeFree Detail
<0.001 Congenital absence of liver Pneumonia alone (without endotoxemia) was effectively controlled in the absence ... BeFree 26216424 Detail
<0.001 Postpartum cardiomyopathy NA BeFree Detail
<0.001 Impaired glucose tolerance NA BeFree Detail
<0.001 Virchow's node (disorder) Our findings implicate STAT3 as a critical signaling node in BCR-ABL1 kinase-ind... BeFree 25134459 Detail
<0.001 Pneumonia due to Escherichia coli NA BeFree Detail
<0.001 Stage II Colon Cancer NA BeFree Detail
<0.001 Carcinoma breast stage IV NA BeFree Detail
<0.001 Metastatic Renal Cell Cancer NA BeFree Detail
<0.001 gastric adenocarcinoma NA BeFree Detail
<0.001 Metastatic melanoma NA BeFree Detail
0.003 Cancer of Head and Neck NA BeFree Detail
0.002 Liver and Intrahepatic Biliary Tract Carcinoma Effects of mTOR-STAT3 on the migration and invasion abilities of hepatoma cell a... BeFree 25063062 Detail
0.002 Liver and Intrahepatic Biliary Tract Carcinoma We proposed that PKM2 activates transcription of hypoxia inducible factor-1α (HI... BeFree 25661370 Detail
0.002 Squamous cell carcinoma of esophagus JAK2 inhibitor blocks the inflammation and growth of esophageal squamous cell ca... BeFree 25405520 Detail
0.002 Squamous cell carcinoma of esophagus Dasatinib enhances cisplatin sensitivity in human esophageal squamous cell carci... BeFree 25843419 Detail
<0.001 Adenocarcinoma Of Esophagus NA BeFree Detail
<0.001 bladder squamous cell carcinoma Given that the tumor-promoting inflammation has been previously established in s... BeFree 24448750 Detail
<0.001 Conventional (Clear Cell) Renal Cell Carcinoma Expression of MEKK3, survivin and stat3 mRNA was significantly higher in RCCC th... BeFree 25388155 Detail
0.004 Solid tumour Therefore, sugiol is the first compound regulating STAT3 activity via modulation... BeFree 26212545 Detail
<0.001 laryngeal squamous cell carcinoma NA BeFree Detail
0.003 cervix carcinoma miR-21 and Let-7a along with STAT3 may prove useful targets for pharmacological ... BeFree 25539644 Detail
0.003 cervix carcinoma Blockage of PTPRJ promotes cell growth and resistance to 5-FU through activation... BeFree 25634668 Detail
0.003 cervix carcinoma These results suggest that polymorphisms in STAT2, STAT3 and IFN-γ genes are not... BeFree 25921106 Detail
<0.001 Dermatitis verrucosa The migration and invasion abilities of cells and expression of STAT3 were detec... BeFree 25063062 Detail
<0.001 Obesity, Abdominal NA BeFree Detail
<0.001 Air cyst NA BeFree Detail
<0.001 Tumor necrosis NA BeFree Detail
0.120 Atrophic NA CTD_human Detail
<0.001 Hyperplastic Polyp NA BeFree Detail
<0.001 Squamous cell carcinoma, metastatic CCR7 regulates cell migration and invasion through JAK2/STAT3 in metastatic squa... BeFree 25405202 Detail
<0.001 malignant fibrous histiocytoma NA BeFree Detail
<0.001 anaplastic astrocytoma NA BeFree Detail
0.001 Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse The STAT3 inhibitor WP1066 synergizes with vorinostat to induce apoptosis of man... BeFree 26116769 Detail
<0.001 Impaired cognition Expression of early growth response 1 affects miR-106a/signal transducer and act... BeFree 24686449 Detail
<0.001 Arterial aneurysm NA BeFree Detail
<0.001 Aortic aneurysm without mention of rupture NOS NA BeFree Detail
<0.001 Human papilloma virus infection NA BeFree Detail
<0.001 Carcinoma ex pleomorphic adenoma NA BeFree Detail
0.002 Malignant neoplasm of liver Effects of mTOR-STAT3 on the migration and invasion abilities of hepatoma cell a... BeFree 25063062 Detail
0.002 Malignant neoplasm of liver We proposed that PKM2 activates transcription of hypoxia inducible factor-1α (HI... BeFree 25661370 Detail
<0.001 malignant mesothelioma Low PIAS3 expression in malignant mesothelioma is associated with increased STAT... BeFree 25124686 Detail
<0.001 Growth Hormone-Secreting Pituitary Adenoma STAT3 upregulation in pituitary somatotroph adenomas induces growth hormone hype... BeFree 25774503 Detail
<0.001 chronic eosinophilic leukemia NA BeFree Detail
<0.001 Multiple malignancy NA BeFree Detail
0.011 Malignant neoplasm of pancreas STAT3 induces anoikis resistance, promotes cell invasion and metastatic potentia... BeFree 25411359 Detail
0.011 Malignant neoplasm of pancreas MiR-1181 inhibits stem cell-like phenotypes and suppresses SOX2 and STAT3 in hum... BeFree 25444909 Detail
0.011 Malignant neoplasm of pancreas Thus, inhibition of HIF-1α and Stat3 is a potential therapeutic strategy for pan... BeFree 25655308 Detail
0.011 Malignant neoplasm of pancreas Collectively, our results provide the first evidence for the presence of the syn... BeFree 25779676 Detail
<0.001 Disseminated Malignant Neoplasm NA BeFree Detail
<0.001 Pleomorphic adenoma of parotid gland Activation of the interleukin-6/Janus kinase/STAT3 pathway in pleomorphic adenom... BeFree 26061266 Detail
<0.001 juvenile myelomonocytic leukemia NA BeFree Detail
<0.001 Pulmonary lymphangioleiomyomatosis NA BeFree Detail
0.002 Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site Jak1/Stat3 is an upstream signaling of NF-κB activation in Helicobacter pylori-i... BeFree 25837197 Detail
0.015 Malignant neoplasm of prostate Prostate cancer is frequently associated with elevated levels of interleukin-6 (... BeFree 25243457 Detail
0.015 Malignant neoplasm of prostate This data suggests that targeting both tumor initiating and differentiated cell ... BeFree 25261365 Detail
0.015 Malignant neoplasm of prostate Activation of proliferation promoting signaling pathways (including β-catenin, c... BeFree 25566960 Detail
0.015 Malignant neoplasm of prostate Genome-wide methylation analysis showed differential methylation in several key ... BeFree 25631332 Detail
<0.001 Hematopoietic Neoplasms NA BeFree Detail
<0.001 Hematologic Neoplasms NA BeFree Detail
0.080 Sepsis-Associated Encephalopathy NA RGD Detail
0.002 Primary immune deficiency disorder Chronic mucocutaneous candidiasis (CMC) and hyper-IgE syndrome (HIES) are primar... BeFree 23796786 Detail
0.002 Primary immune deficiency disorder HIES are a group of primary immunodeficiencies with overlapping and distinct fea... BeFree 25469836 Detail
0.080 Non-alcoholic Fatty Liver Disease NA BeFree,RGD Detail
<0.001 lupus erythematosus Stat3 promotes IL-10 expression in lupus T cells through trans-activation and ch... BeFree 25187566 Detail
0.001 endometrial carcinoma IL6/JAK1/STAT3 Signaling Blockade in Endometrial Cancer Affects the ALDHhi/CD126... BeFree 26130650 Detail
0.001 Sleep Apnea, Obstructive NA BeFree Detail
0.001 Recurrent tumor NA BeFree Detail
<0.001 Neurodegenerative Disorders In this study, we examined whether the JAK/STAT3 pathway promotes astrocyte reac... BeFree 25673868 Detail
0.003 Hepatitis C, Chronic NA LHGDN Detail
0.002 Malignant neoplasm of esophagus AURKA regulates JAK2-STAT3 activity in human gastric and esophageal cancers. BeFree 24953013 Detail
0.001 Thyroid carcinoma NA BeFree Detail
<0.001 Ewings sarcoma NA BeFree Detail
<0.001 Squamous cell carcinoma of skin To investigate the regulatory effect of curcumin on expression of signal transdu... BeFree 25854367 Detail
<0.001 Malignant glioma NA BeFree Detail
<0.001 tongue carcinoma NA BeFree Detail
<0.001 Congenital scoliosis NA BeFree Detail
0.002 Osteosarcoma of bone Efficacy of the FLLL32 pharmacological inhibitor in delaying OS growth suggests ... BeFree 25760445 Detail
0.002 Osteosarcoma of bone Leukemia inhibitory factor promotes tumor growth and metastasis in human osteosa... BeFree 26271643 Detail
0.001 Carcinoma of larynx ERp57 modulates STAT3 activity in radioresistant laryngeal cancer cells and serv... BeFree 25605256 Detail
0.038 Carcinogenesis In our study, we examined a new therapeutic alternative in the treatment of mult... BeFree 24627437 Detail
0.038 Carcinogenesis Although the role of STAT3 and wild-type NPM in oncogenesis has been extensively... BeFree 24793791 Detail
0.038 Carcinogenesis Functionally, RRAD contributes to the activation of STAT3 and expression of the ... BeFree 25313011 Detail
0.038 Carcinogenesis This study aimed to investigate the correlation of RKIP, STAT3 and cyclin D1 exp... BeFree 25337233 Detail
0.038 Carcinogenesis Sphingosine-1-phosphate lyase downregulation promotes colon carcinogenesis throu... BeFree 25347472 Detail
0.038 Carcinogenesis The present study aimed to investigate the role of the JAK/STAT3 pathway in the ... BeFree 25405520 Detail
0.038 Carcinogenesis HIF-1α and Stat3 function cooperatively to regulate a number of downstream genes... BeFree 25655308 Detail
0.038 Carcinogenesis Oncovirus Kaposi sarcoma herpesvirus (KSHV) represses tumor suppressor PDLIM2 to... BeFree 25681443 Detail
0.038 Carcinogenesis Suppressor of cytokine signaling 3 (SOCS3) is a major negative regulator of sign... BeFree 25695729 Detail
0.038 Carcinogenesis In this review, we focus on the role of STAT3 in tumorigenesis, and discuss its ... BeFree 25825152 Detail
0.038 Carcinogenesis Overall, our study suggests that the microRNAs, miR-21 and let-7a function as cl... BeFree 26051842 Detail
0.038 Carcinogenesis The interleukin-6 (IL-6)/Janus kinase (JAK)/signal transducer and activator of t... BeFree 26061266 Detail
0.002 Leukemogenesis NA BeFree Detail
<0.001 Tumor Initiation NA BeFree Detail
0.016 prostate carcinoma Prostate cancer is frequently associated with elevated levels of interleukin-6 (... BeFree 25243457 Detail
0.016 prostate carcinoma This data suggests that targeting both tumor initiating and differentiated cell ... BeFree 25261365 Detail
0.016 prostate carcinoma Activation of proliferation promoting signaling pathways (including β-catenin, c... BeFree 25566960 Detail
0.016 prostate carcinoma Genome-wide methylation analysis showed differential methylation in several key ... BeFree 25631332 Detail
0.128 Leukemia, Myelocytic, Acute Thus, while JAK2 V617F is uncommon in de novo AML and probably does not occur in... BeFree 16598306 Detail
0.004 Primary myelofibrosis Janus kinase 2 (V617F) mutation status, signal transducer and activator of trans... BeFree 16871275 Detail
0.002 Epithelial ovarian cancer Targeted Blockade of JAK/STAT3 Signaling Inhibits Ovarian Carcinoma Growth. BeFree 25646015 Detail
<0.001 Progressive Neoplastic Disease NA BeFree Detail
0.027 breast carcinoma The efficiency of PEI/STAT3-siRNA polyplexes in the induction of STAT3 associate... BeFree 24167124 Detail
0.027 breast carcinoma Drug-repositioning screening identified piperlongumine as a direct STAT3 inhibit... BeFree 24681959 Detail
0.027 breast carcinoma These findings identify CXCR7-mediated STAT3 activation and modulation of the tu... BeFree 24886617 Detail
0.027 breast carcinoma Obatoclax analog SC-2001 inhibits STAT3 phosphorylation through enhancing SHP-1 ... BeFree 24903225 Detail
0.027 breast carcinoma MRTF-A and STAT3 synergistically promote breast cancer cell migration. BeFree 25038455 Detail
0.027 breast carcinoma After adjustment for multiple comparisons, JAK1 (three of ten SNPs) and JAK2 (4 ... BeFree 25104439 Detail
0.027 breast carcinoma rhIL-24 circumvented the drug-resistance of MCF-7/ADM cells via activation of th... BeFree 25150001 Detail
0.027 breast carcinoma In human breast cancer MCF-7 cells, ER stress activator tunicamycin increased th... BeFree 25231320 Detail
0.027 breast carcinoma Zerumbone suppresses EGF-induced CD44 expression through the inhibition of STAT3... BeFree 25269647 Detail
0.027 breast carcinoma Signal transducer and activator of transcription 3 (STAT3) is implicated breast ... BeFree 25301089 Detail
0.027 breast carcinoma Activation of STAT3 is involved in malignancy mediated by CXCL12-CXCR4 signaling... BeFree 25310198 Detail
0.027 breast carcinoma These results provide preclinical evidence to continue the development of alanto... BeFree 25434800 Detail
0.027 breast carcinoma This study disclosed concomitant expression of TAMs marker-CD163 with SOX2 in hu... BeFree 25444903 Detail
0.027 breast carcinoma Signal transducer and activator of transcription 3 (STAT3) has been linked to br... BeFree 25481644 Detail
0.027 breast carcinoma STAT3 genetic variant, alone and in combination with STAT5b polymorphism, contri... BeFree 25487443 Detail
0.027 breast carcinoma Notch1 induces epithelial-mesenchymal transition and the cancer stem cell phenot... BeFree 25544568 Detail
0.027 breast carcinoma Crispene E, a cis-clerodane diterpene inhibits STAT3 dimerization in breast canc... BeFree 25721973 Detail
0.027 breast carcinoma JSI-124 (Cucurbitacin I) inhibits tumor angiogenesis of human breast cancer thro... BeFree 25787299 Detail
0.027 breast carcinoma Together, our results show how targeting STAT3-G9a signaling regulates CSC plast... BeFree 25840984 Detail
0.027 breast carcinoma Signal transducer and activator of transcription 3 and 5 regulate system Xc- and... BeFree 25896132 Detail
0.027 breast carcinoma STAT3 and STAT5b polymorphism contributes to breast cancer risk and clinical out... BeFree 25973100 Detail
0.027 breast carcinoma Recently, signal transducer and activator of transcription 3 (STAT3) activation ... BeFree 26158169 Detail
<0.001 myelofibrosis Janus kinase 2 (V617F) mutation status, signal transducer and activator of trans... BeFree 16871275 Detail
0.011 Carcinoma of lung PS2 knockout mice and PS2 knockdown lung cancer cells showed increased DNA-bindi... BeFree 24858037 Detail
0.011 Carcinoma of lung IL6 signaling was blocked with antibodies against IL6, soluble glycoprotein 130 ... BeFree 25461668 Detail
0.011 Carcinoma of lung STAT3 is considered to play an oncogenic role in several malignancies including ... BeFree 25734337 Detail
<0.001 Malignant neoplasm of gastrointestinal tract NA BeFree Detail
0.003 Secondary malignant neoplasm of lymph node The immunohistochemistry results also showed that the phosphorylation of STAT3 w... BeFree 25405202 Detail
0.003 Secondary malignant neoplasm of lymph node In NSCLC, the expression levels of miR-124 and STAT3 correlated significantly wi... BeFree 25531908 Detail
0.011 stomach carcinoma Silibinin inhibits proliferation, induces apoptosis and causes cell cycle arrest... BeFree 25169527 Detail
0.011 stomach carcinoma Piperine inhibits IL-1β-induced IL-6 expression by suppressing p38 MAPK and STAT... BeFree 25234193 Detail
0.011 stomach carcinoma Combinatorial targeting on both HER2 and STAT3 may enhance the efficacy of trast... BeFree 25327561 Detail
0.011 stomach carcinoma Correlation of RKIP, STAT3 and cyclin D1 expression in pathogenesis of gastric c... BeFree 25337233 Detail
0.011 stomach carcinoma Taken together, these findings indicate that down-regulation of miR-874 contribu... BeFree 25596740 Detail
0.011 stomach carcinoma Thus, dual use of STAT3 and GSK-3β inhibitors may enhance the efficacy of the an... BeFree 25846563 Detail
0.003 Carcinoma of bladder Urothelial bladder carcinoma displayed elevated expression as well as activation... BeFree 24448750 Detail
0.003 Carcinoma of bladder Cell cycle-defective phosphomimetic p27T157DT198D (p27CK-DD) activates STAT3 to ... BeFree 25684140 Detail
0.002 Central neuroblastoma NA BeFree Detail
<0.001 Acquired scoliosis NA BeFree Detail
0.120 Infarction, Middle Cerebral Artery NA CTD_human Detail
0.080 hyperuricemia NA RGD Detail
0.003 Malignant neoplasm of kidney NA BeFree,GAD Detail
<0.001 Poorly differentiated carcinoma NA BeFree Detail
<0.001 Cardiac defects NA BeFree Detail
<0.001 Hypereosinophilia NA BeFree Detail
<0.001 Primary malignant neoplasm of brain We have reported that basic fibroblast growth factor (bFGF) demonstrates an inti... BeFree 25048528 Detail
<0.001 Primary malignant neoplasm of brain These data suggest that aberrant activation of STAT-3, which is observed in mali... BeFree 25246098 Detail
<0.001 Memory Loss We propose a hypothesis accounting for memory impairment related to MHE: DA-depe... BeFree 25500624 Detail
<0.001 lymphangioleiomyomatosis NA BeFree Detail
0.002 Multiple Sclerosis, Relapsing-Remitting NA GAD Detail
<0.001 malignant pleural mesothelioma NA BeFree Detail
<0.001 Helicobacter pylori infection Here, we report that H. pylori infection activated the signal transducer and act... BeFree 25412627 Detail
<0.001 Rhabdoid Tumor of the Kidney NA BeFree Detail
<0.001 vascular aneurysm NA BeFree Detail
<0.001 breast adenocarcinoma NA BeFree Detail
<0.001 latent infection NA BeFree Detail
<0.001 Advanced cancer NA BeFree Detail
0.123 Cardiomyopathies NA CTD_human,LHGDN Detail
<0.001 Arteriovenous Malformations, Cerebral NA BeFree Detail
0.132 ovarian neoplasm Previous studies showed that downregulation of STAT3 using specific short hairpi... BeFree,CTD_human,LHGDN 25420630 Detail
0.132 ovarian neoplasm Taken together, our results show pharmacologic inhibition of the JAK2/STAT3 path... BeFree,CTD_human,LHGDN 25646015 Detail
0.002 Genomic Instability NA GAD Detail
<0.001 Acute coronary syndrome Modulation of STAT3 and STAT5 activity rectifies the imbalance of Th17 and Treg ... BeFree 25572535 Detail
<0.001 Colorectal cancer metastatic NA BeFree Detail
<0.001 Arthritis, Collagen-Induced NA BeFree Detail
0.200 Arthritis, Experimental NA CTD_human,RGD Detail
<0.001 Gestational Trophoblastic Neoplasms NA BeFree Detail
0.009 Malignant neoplasm of ovary Altogether, our results demonstrate that targeting JAK1/STAT3, using shRNA knock... BeFree,GAD 25319391 Detail
0.009 Malignant neoplasm of ovary Ginsenoside 20(S)‑Rg3 inhibits the Warburg effect through STAT3 pathways in ovar... BeFree,GAD 25405516 Detail
0.009 Malignant neoplasm of ovary Synergistic effects of eukaryotic co-expression plasmid-based STAT3-specific siR... BeFree,GAD 25420630 Detail
0.009 Malignant neoplasm of ovary Here, we report results that may explain this outcome, based on the finding that... BeFree,GAD 25670170 Detail
0.009 Malignant neoplasm of ovary STAT3 Decoy Oligodeoxynucleotides-Loaded Solid Lipid Nanoparticles Induce Cell D... BeFree,GAD 25923701 Detail
<0.001 endometrial adenocarcinoma Lastly, we confirmed this IL-6 induction of both STAT3 phosphorylation and HIF1A... BeFree 25750101 Detail
0.008 Squamous cell carcinoma of the head and neck In conclusion, JAk2/STAT3 plays a key role in CCR7 regulating SCCHN metastasis. BeFree 25405202 Detail
0.008 Squamous cell carcinoma of the head and neck JAK kinase inhibition abrogates STAT3 activation and head and neck squamous cell... BeFree 25810010 Detail
0.008 Squamous cell carcinoma of the head and neck NF-κB and stat3 transcription factor signatures differentiate HPV-positive and H... BeFree 25857630 Detail
<0.001 severe acute respiratory syndrome Predicted activation for STAT3 mediating gene expression relevant for epithelial... BeFree 25534508 Detail
<0.001 Ductal Carcinoma NA BeFree Detail
<0.001 Morphologically altered structure In this study, we found that STAT3 activation induced by EGF was associated sign... BeFree 26158169 Detail
<0.001 sarcoma NA BeFree Detail
<0.001 Non-small cell carcinoma NA BeFree Detail
<0.001 Intracortical osteosarcoma Correlation between ERK1 and STAT3 expression and chemoresistance in patients wi... BeFree 25146150 Detail
0.004 Primary Effusion Lymphoma NA BeFree,LHGDN Detail
<0.001 Chronic myeloproliferative disorder Our results demonstrate that JAK-STAT3-mediated cytokine production from maligna... BeFree 25572172 Detail
<0.001 Pancreatic intraepithelial neoplasia NA BeFree Detail
<0.001 Adenoma of large intestine NA BeFree Detail
<0.001 Liver regeneration disorder NA BeFree Detail
<0.001 Hormone refractory prostate cancer NA BeFree Detail
<0.001 autoimmune lymphoproliferative syndrome Combined, these data show that an IL-10/Janus kinase/signal transducer and activ... BeFree 25174872 Detail
0.001 Anaplastic Large Cell Lymphoma, ALK-Positive The tumorigenicity of most cases of ALK-positive anaplastic large-cell lymphoma ... BeFree 25921060 Detail
<0.001 Classical Hodgkin's Lymphoma NA BeFree Detail
<0.001 ALK positive large B-cell lymphoma NA BeFree Detail
0.001 pancreatic ductal adenocarcinoma NA BeFree Detail
<0.001 renal carcinoma NA BeFree Detail
<0.001 Primary Lesion NA BeFree Detail
0.160 Mammary Neoplasms Effective down-regulation of signal transducer and activator of transcription 3 ... BeFree,CTD_human,LHGDN 24167124 Detail
0.160 Mammary Neoplasms Furthermore, our results in the clinic revealed that nuclear interaction between... BeFree,CTD_human,LHGDN 25174405 Detail
<0.001 grade II meningioma NA BeFree Detail
<0.001 Hepatocarcinogenesis NA BeFree Detail
<0.001 ovarian clear cell adenocarcinoma NA BeFree Detail
<0.001 Skin Carcinogenesis NA BeFree Detail
0.003 Tumor Angiogenesis Taken together, these findings indicate that down-regulation of miR-874 contribu... BeFree 25596740 Detail
0.003 Tumor Angiogenesis JSI-124 (Cucurbitacin I) inhibits tumor angiogenesis of human breast cancer thro... BeFree 25787299 Detail
0.001 Tumor Promotion NA BeFree Detail
<0.001 Xenograft Model NA BeFree Detail
0.002 Leukemia, Large Granular Lymphocytic The analysis of clonal diversity and therapy responses using STAT3 mutations as ... BeFree 25281507 Detail
0.008 colorectal cancer Overall, this study suggests that PKM2 overexpression promotes CRC cell migratio... BeFree 24686087 Detail
0.008 colorectal cancer Using a unique systems biology approach, we identified JAK1/2-dependent activati... BeFree 24931611 Detail
0.008 colorectal cancer Genome-wide uncovering of STAT3-mediated miRNA expression profiles in colorectal... BeFree 25126546 Detail
0.008 colorectal cancer Therefore, miR-27a could be a useful biomarker for monitoring colorectal cancer ... BeFree 25166914 Detail
0.008 colorectal cancer Th17-type cytokines, IL-6 and TNF-α synergistically activate STAT3 and NF-kB to ... BeFree 25174402 Detail
0.008 colorectal cancer This suggests that STAT3 positively regulates β-catenin (at a transcriptional le... BeFree 25348333 Detail
0.008 colorectal cancer Inhibition of STAT3/cyclinD1 pathway increased the sensitivity of colorectal can... BeFree 25617735 Detail
0.008 colorectal cancer Aberrantly expressed Fra-1 by IL-6/STAT3 transactivation promotes colorectal can... BeFree 25750173 Detail
0.003 Sjogren's syndrome NA LHGDN Detail
<0.001 Ductal Breast Carcinoma NA BeFree Detail
<0.001 Non-Malignant Ascites Adverse Event The constitutive activation of STAT3 in human ovarian cancer cells appeared to b... BeFree 25319391 Detail
<0.001 Non-Malignant Ascites Adverse Event AZD1480 treatment inhibited STAT3 phosphorylation and DNA binding, and migration... BeFree 25646015 Detail
<0.001 Polycystic Kidney - body part NA BeFree Detail
0.002 Glioblastoma multiforme Whereas the ERK1/2 and STAT3 pathways independently promote proliferation and re... BeFree 24951116 Detail
0.002 Glioblastoma multiforme Although EGFR phosphorylation and STAT3 activation are essential for the mainten... BeFree 25313011 Detail
<0.001 Cirrhosis NA BeFree Detail
<0.001 tumor vasculature NA BeFree Detail
<0.001 bone sarcoma NA BeFree Detail
<0.001 Non-Neoplastic Disorder NA BeFree Detail
0.001 Meningioma, benign, no ICD-O subtype NA BeFree Detail
<0.001 familial medullary thyroid carcinoma NA BeFree Detail
<0.001 SPEECH-SOUND DISORDER SSD treatment inhibited STAT3 activation [phosphorylation of STAT3 (p‑STAT3)], r... BeFree 25231214 Detail
<0.001 IMMUNE SUPPRESSION miR-146a is directly regulated by STAT3 in human hepatocellular carcinoma cells ... BeFree 25607648 Detail
<0.001 IMMUNE SUPPRESSION STAT3 has many roles in physiological processes such as inflammatory signalling,... BeFree 25825152 Detail
<0.001 Recurrent infections (sinusitis and bacterial pneumonia and meningitis) NA BeFree Detail
<0.001 lateral meningocele syndrome NA BeFree Detail
0.120 Copper-Overload Cirrhosis NA CTD_human Detail
<0.001 uterine corpus cancer IL6/JAK1/STAT3 Signaling Blockade in Endometrial Cancer Affects the ALDHhi/CD126... BeFree 26130650 Detail
0.003 T-cell large granular lymphocyte leukemia STAT3 mutation was detected in 12% of the cohort, which is lower than the freque... BeFree 25096606 Detail
0.003 T-cell large granular lymphocyte leukemia The analysis of clonal diversity and therapy responses using STAT3 mutations as ... BeFree 25281507 Detail
0.003 T-cell large granular lymphocyte leukemia The pathogenesis of T-cell large granular lymphocytic leukemia (T-LGL) is poorly... BeFree 26199174 Detail
<0.001 Pulmonary Stenosis NA BeFree Detail
0.003 Precursor Cell Lymphoblastic Leukemia Lymphoma NA BeFree,GAD Detail
<0.001 Hyper-Immunoglobulin E Syndrome, Autosomal Recessive NA BeFree Detail
<0.001 low grade glioma NA BeFree Detail
<0.001 Urothelial Carcinoma High NF-κB and STAT3 activity in human urothelial carcinoma: a pilot study. BeFree 24448750 Detail
0.021 liver carcinoma A novel miR-219-SMC4-JAK2/Stat3 regulatory pathway in human hepatocellular carci... BeFree,GAD 24980149 Detail
0.021 liver carcinoma Effects of mTOR-STAT3 on the migration and invasion abilities of hepatoma cell a... BeFree,GAD 25063062 Detail
0.021 liver carcinoma Transcriptional regulation of STAT3 by SPTBN1 and SMAD3 in HCC through cAMP-resp... BeFree,GAD 25096061 Detail
0.021 liver carcinoma The iron chelator Dp44mT inhibits hepatocellular carcinoma metastasis via N-Myc ... BeFree,GAD 25261367 Detail
0.021 liver carcinoma Suppression of STAT3 phosphorylation by CIMO and knockdown of STAT3 mRNA using s... BeFree,GAD 25320076 Detail
0.021 liver carcinoma We found that IL-8: i) may induce EMT and promote HCC cell migration and invasio... BeFree,GAD 25405790 Detail
0.021 liver carcinoma Antitumor progression potential of morusin suppressing STAT3 and NFκB in human h... BeFree,GAD 25476160 Detail
0.021 liver carcinoma STAT3 regulates the migration and invasion of a stem‑like subpopulation through ... BeFree,GAD 25571964 Detail
0.021 liver carcinoma miR-146a is directly regulated by STAT3 in human hepatocellular carcinoma cells ... BeFree,GAD 25607648 Detail
0.021 liver carcinoma Finally, when administered intraperitoneally, ASC also inhibited tumor growth in... BeFree,GAD 25624051 Detail
0.021 liver carcinoma STAT3 cooperates with Twist to mediate epithelial-mesenchymal transition in huma... BeFree,GAD 25653024 Detail
0.021 liver carcinoma Invasion and migration of HCC cells in vitro were inhibited by both STAT3 and mi... BeFree,GAD 25720799 Detail
0.021 liver carcinoma These results indicate that PML modulates IL-6-induced STAT3 activation and hepa... BeFree,GAD 25892518 Detail
0.021 liver carcinoma STAT3 activation mediates epithelial-to-mesenchymal transition in human hepatoce... BeFree,GAD 26158169 Detail
<0.001 Hyperdiploid B Acute Lymphoblastic Leukemia NA BeFree Detail
<0.001 Clinically isolated syndrome NA BeFree Detail
<0.001 Neutropenia, severe chronic NA BeFree Detail
<0.001 Gestational trophoblastic disease NA BeFree Detail
0.003 Nasopharyngeal carcinoma Activation of miR-21 by STAT3 induces proliferation and suppresses apoptosis in ... BeFree 25365510 Detail
0.122 Hyper-Immunoglobulin E Syndrome, Autosomal Dominant NA BeFree,ORPHANET Detail
<0.001 Pulmonary arterial hypertension NA BeFree Detail
<0.001 Stage II Colon Cancer AJCC v7 NA BeFree Detail
<0.001 myelodysplastic syndrome NA BeFree Detail
<0.001 Hydatidiform mole, recurrent, 1 NA BeFree Detail
0.440 Hyper-Ige Recurrent Infection Syndrome, Autosomal Dominant NA CTD_human,MGD,ORPHANET,UNIPROT Detail
0.120 Juvenile arthritis NA CTD_human Detail
<0.001 Progressive cGVHD NA BeFree Detail
0.001 Triple Negative Breast Neoplasms Induction of fibronectin in response to epidermal growth factor is suppressed by... BeFree 25175149 Detail
0.003 Infection NA LHGDN Detail
<0.001 Pneumonitis Induction of STAT3-Dependent CXCL5 Expression and Neutrophil Recruitment by Onco... BeFree 25692402 Detail
<0.001 Pneumonitis Taken together, induction of liver STAT3-dependent gene expression programs is e... BeFree 26216424 Detail
<0.001 Pulmonary hypertension, primary, 1, with hereditary hemorrhagic telangiectasia NA BeFree Detail
<0.001 Experimental Organism Basal Cell Carcinoma NA BeFree Detail
0.135 Job Syndrome NA CTD_human,GAD,LHGDN Detail
0.120 AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET NA UNIPROT Detail
<0.001 Apert syndrome NA BeFree Detail
0.003 Acute-Phase Reaction NA LHGDN Detail
0.134 adenocarcinoma NA BeFree,CTD_human,LHGDN Detail
<0.001 adenoma Together, these results indicate that adenoma GH hypersecretion is the result of... BeFree 25774503 Detail
0.004 Primary myelofibrosis NA BeFree,LHGDN Detail
0.001 Alzheimer's disease Here we show that the Humanin signaling pathway via htHNR/JAKs/STAT3 increased t... BeFree 25138702 Detail
0.001 Alzheimer's disease The JAK/STAT3 pathway was activated in reactive astrocytes in two transgenic mou... BeFree 25673868 Detail
<0.001 Amnesia We propose a hypothesis accounting for memory impairment related to MHE: DA-depe... BeFree 25500624 Detail
<0.001 aplastic anemia Germline loss-of-function mutations in the transcription factor signal transduce... BeFree 25359994 Detail
<0.001 Anorexia NA BeFree Detail
0.003 Anoxia NA LHGDN Detail
<0.001 aortic aneurysm NA BeFree Detail
0.001 arteriosclerosis NA BeFree Detail
0.001 arthritis NA BeFree Detail
<0.001 Arthritis, Adjuvant-Induced NA BeFree Detail
0.004 rheumatoid arthritis This is the first study to provide evidence of a functional link between HIF1α, ... BeFree 24525913 Detail
0.004 rheumatoid arthritis Treatment with an approved TNFα blocking antibody showed marked reduction in the... BeFree 25436214 Detail
0.004 rheumatoid arthritis CD4 T-cell transcriptome analysis reveals aberrant regulation of STAT3 and Wnt s... BeFree 25880754 Detail
0.011 asthma NA BeFree,GAD,LHGDN Detail
0.001 Astrocytoma STAT-3 knockdown decreased OSM-mediated expression of ADM, indicating that ADM e... BeFree 25246098 Detail
0.003 ataxia telangiectasia NA LHGDN Detail
0.121 atherosclerosis NA BeFree,CTD_human Detail
0.003 atrial fibrillation NA LHGDN Detail
0.123 Autoimmune Diseases Interleukin-23 receptor (IL-23R) and signal transducer and activator of transcri... BeFree,CTD_human 24460100 Detail
0.123 Autoimmune Diseases T-helper 17 (Th17) cells, a recently identified CD4+ T subset with a unique char... BeFree,CTD_human 25263529 Detail
0.123 Autoimmune Diseases Recently, germline mutations in STAT3 have also been associated with autoimmune ... BeFree,CTD_human 25359994 Detail
<0.001 Melanoma, B16 NA BeFree Detail
<0.001 Bacterial Infections NA BeFree Detail
<0.001 Pneumonia, Bacterial NA BeFree Detail
<0.001 Behcet Syndrome Basal US total STAT3 expression was significantly higher in BD (1.2 vs 3.45, P <... BeFree 25410656 Detail
<0.001 biliary atresia Expression of IL-6, Foxa2, and phosphorylated signal transducer activator of tra... BeFree 25450715 Detail
0.003 Malignant neoplasm of urinary bladder Cell cycle-defective phosphomimetic p27T157DT198D (p27CK-DD) activates STAT3 to ... BeFree 25684140 Detail
0.005 Bladder Neoplasm NA LHGDN Detail
<0.001 borderline personality disorder NA BeFree Detail
0.003 Bowen's Disease NA LHGDN Detail
0.001 Brain Neoplasms NA BeFree Detail
0.030 Malignant neoplasm of breast The efficiency of PEI/STAT3-siRNA polyplexes in the induction of STAT3 associate... BeFree,GAD 24167124 Detail
0.030 Malignant neoplasm of breast Drug-repositioning screening identified piperlongumine as a direct STAT3 inhibit... BeFree,GAD 24681959 Detail
0.030 Malignant neoplasm of breast These findings identify CXCR7-mediated STAT3 activation and modulation of the tu... BeFree,GAD 24886617 Detail
0.030 Malignant neoplasm of breast Obatoclax analog SC-2001 inhibits STAT3 phosphorylation through enhancing SHP-1 ... BeFree,GAD 24903225 Detail
0.030 Malignant neoplasm of breast MRTF-A and STAT3 synergistically promote breast cancer cell migration. BeFree,GAD 25038455 Detail
0.030 Malignant neoplasm of breast After adjustment for multiple comparisons, JAK1 (three of ten SNPs) and JAK2 (4 ... BeFree,GAD 25104439 Detail
0.030 Malignant neoplasm of breast rhIL-24 circumvented the drug-resistance of MCF-7/ADM cells via activation of th... BeFree,GAD 25150001 Detail
0.030 Malignant neoplasm of breast In human breast cancer MCF-7 cells, ER stress activator tunicamycin increased th... BeFree,GAD 25231320 Detail
0.030 Malignant neoplasm of breast Zerumbone suppresses EGF-induced CD44 expression through the inhibition of STAT3... BeFree,GAD 25269647 Detail
0.030 Malignant neoplasm of breast Signal transducer and activator of transcription 3 (STAT3) is implicated breast ... BeFree,GAD 25301089 Detail
0.030 Malignant neoplasm of breast Activation of STAT3 is involved in malignancy mediated by CXCL12-CXCR4 signaling... BeFree,GAD 25310198 Detail
0.030 Malignant neoplasm of breast These results provide preclinical evidence to continue the development of alanto... BeFree,GAD 25434800 Detail
0.030 Malignant neoplasm of breast This study disclosed concomitant expression of TAMs marker-CD163 with SOX2 in hu... BeFree,GAD 25444903 Detail
0.030 Malignant neoplasm of breast Signal transducer and activator of transcription 3 (STAT3) has been linked to br... BeFree,GAD 25481644 Detail
0.030 Malignant neoplasm of breast STAT3 genetic variant, alone and in combination with STAT5b polymorphism, contri... BeFree,GAD 25487443 Detail
0.030 Malignant neoplasm of breast Notch1 induces epithelial-mesenchymal transition and the cancer stem cell phenot... BeFree,GAD 25544568 Detail
0.030 Malignant neoplasm of breast Crispene E, a cis-clerodane diterpene inhibits STAT3 dimerization in breast canc... BeFree,GAD 25721973 Detail
0.030 Malignant neoplasm of breast JSI-124 (Cucurbitacin I) inhibits tumor angiogenesis of human breast cancer thro... BeFree,GAD 25787299 Detail
0.030 Malignant neoplasm of breast Together, our results show how targeting STAT3-G9a signaling regulates CSC plast... BeFree,GAD 25840984 Detail
0.030 Malignant neoplasm of breast Signal transducer and activator of transcription 3 and 5 regulate system Xc- and... BeFree,GAD 25896132 Detail
0.030 Malignant neoplasm of breast STAT3 and STAT5b polymorphism contributes to breast cancer risk and clinical out... BeFree,GAD 25973100 Detail
0.030 Malignant neoplasm of breast Recently, signal transducer and activator of transcription 3 (STAT3) activation ... BeFree,GAD 26158169 Detail
<0.001 bronchiectasis NA BeFree Detail
0.002 Bronchiolitis, Viral NA GAD Detail
<0.001 bronchopulmonary dysplasia NA BeFree Detail
<0.001 Cachexia NA BeFree Detail
<0.001 candidiasis Mutations affecting the STAT3/interleukin 17 (IL-17) pathway cause selective sus... BeFree 26255980 Detail
<0.001 Candidiasis, Chronic Mucocutaneous Chronic mucocutaneous candidiasis (CMC) and hyper-IgE syndrome (HIES) are primar... BeFree 23796786 Detail
<0.001 Candidiasis, Chronic Mucocutaneous We therefore hypothesized that STAT1 and STAT3 defects have different effects on... BeFree 25880788 Detail
<0.001 Candidiasis, Chronic Mucocutaneous Gain-of-function STAT1 mutations impair STAT3 activity in patients with chronic ... BeFree 26255980 Detail
<0.001 Malignant neoplasm of endometrium IL6/JAK1/STAT3 Signaling Blockade in Endometrial Cancer Affects the ALDHhi/CD126... BeFree 26130650 Detail
<0.001 Malignant neoplasm of larynx ERp57 modulates STAT3 activity in radioresistant laryngeal cancer cells and serv... BeFree 25605256 Detail
<0.001 Adenocarcinoma of prostate STAT3 knockdown significantly impaired the ability of prostate cancer cells to i... BeFree 25261365 Detail
<0.001 Rectal Carcinoma NA BeFree Detail
<0.001 Malignant neoplasm of skin NA BeFree Detail
0.001 Malignant neoplasm of thyroid NA BeFree Detail
0.003 basal cell carcinoma NA LHGDN Detail
0.131 Non-small cell lung carcinoma Essential role of aldehyde dehydrogenase 1A3 for the maintenance of non-small ce... BeFree,CTD_human 24907115 Detail
0.131 Non-small cell lung carcinoma Four human non-small cell lung cancer cell lines were treated with epidermal gro... BeFree,CTD_human 25439778 Detail
0.131 Non-small cell lung carcinoma Reciprocal activation between IL-6/STAT3 and NOX4/Akt signalings promotes prolif... BeFree,CTD_human 25504436 Detail
0.131 Non-small cell lung carcinoma The tumor suppressor miR-124 inhibits cell proliferation by targeting STAT3 and ... BeFree,CTD_human 25531908 Detail
0.131 Non-small cell lung carcinoma This study also suggests that STAT3 inhibitors may aid in the treatment NSCLC pa... BeFree,CTD_human 25695284 Detail
0.131 Non-small cell lung carcinoma Feed-Forward Reciprocal Activation of PAFR and STAT3 Regulates Epithelial-Mesenc... BeFree,CTD_human 26359459 Detail
<0.001 Carcinoma, Papillary NA BeFree Detail
0.006 renal cell carcinoma Finally, when administered i.p., zerumbone inhibited STAT3 activation in tumor t... BeFree,LHGDN 24797723 Detail
Annotation

Annotations

DescrptionSourceLinks
Here we show a clear correlation between the efficacy of anti-EGFR inhibitors with their ability to ... DisGeNET Detail
High NF-κB and STAT3 activity in human urothelial carcinoma: a pilot study. DisGeNET Detail
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miR-21 and Let-7a along with STAT3 may prove useful targets for pharmacological intervention for man... DisGeNET Detail
These results suggest that polymorphisms in STAT2, STAT3 and IFN-γ genes are not likely to be strong... DisGeNET Detail
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GRIM‑19‑mediated Stat3 activation is a determinant for resveratrol‑induced proliferation and cytotox... DisGeNET Detail
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Butein effects in colitis and interleukin-6/signal transducer and activator of transcription 3 expre... DisGeNET Detail
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Overall, this study suggests that PKM2 overexpression promotes CRC cell migration and cell adhesion ... DisGeNET Detail
Using a unique systems biology approach, we identified JAK1/2-dependent activation of STAT3 as the k... DisGeNET Detail
Genome-wide uncovering of STAT3-mediated miRNA expression profiles in colorectal cancer cell lines. DisGeNET Detail
Therefore, miR-27a could be a useful biomarker for monitoring colorectal cancer development and prog... DisGeNET Detail
Th17-type cytokines, IL-6 and TNF-α synergistically activate STAT3 and NF-kB to promote colorectal c... DisGeNET Detail
This suggests that STAT3 positively regulates β-catenin (at a transcriptional level) and evaluation ... DisGeNET Detail
Inhibition of STAT3/cyclinD1 pathway increased the sensitivity of colorectal cancer cell to chemothe... DisGeNET Detail
Aberrantly expressed Fra-1 by IL-6/STAT3 transactivation promotes colorectal cancer aggressiveness t... DisGeNET Detail
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STAT3 controls IL6-dependent regulation of serotonin transporter function and depression-like behavi... DisGeNET Detail
STAT3 controls IL6-dependent regulation of serotonin transporter function and depression-like behavi... DisGeNET Detail
Topical application of the JAK inhibitor suppressed STAT3 activation and improved skin barrier funct... DisGeNET Detail
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Topical application of the JAK inhibitor suppressed STAT3 activation and improved skin barrier funct... DisGeNET Detail
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In addition to the in vitro inhibition of human Th17 cells in a dose-dependent manner, the antagoniz... DisGeNET Detail
Enhanced miR-210 expression promotes the pathogenesis of endometriosis through activation of signal ... DisGeNET Detail
Cross-sectional measurements of STAT3 and HIF1A protein levels in eutopic endometrium from women wit... DisGeNET Detail
AURKA regulates JAK2-STAT3 activity in human gastric and esophageal cancers. DisGeNET Detail
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Inhibition of Jak1/Stat3 may be beneficial for the treatment of H. pylori-induced gastric inflammati... DisGeNET Detail
Blocking the bFGF/STAT3 interaction through specific signaling pathways induces apoptosis in gliobla... DisGeNET Detail
RRAD promotes EGFR-mediated STAT3 activation and induces temozolomide resistance of malignant gliobl... DisGeNET Detail
FoxM1 Drives a Feed-Forward STAT3-Activation Signaling Loop That Promotes the Self-Renewal and Tumor... DisGeNET Detail
Ceacam1L Modulates STAT3 Signaling to Control the Proliferation of Glioblastoma-Initiating Cells. DisGeNET Detail
IL-1 also activated Stat3, a transcription factor crucial in glioma progression. DisGeNET Detail
TRPM7 channels regulate glioma stem cell through STAT3 and Notch signaling pathways. DisGeNET Detail
Furthermore, the suppression of IRG1 expression inhibited the expression of NF-κB and STAT3, suggest... DisGeNET Detail
Suppression of autophagy augments the radiosensitizing effects of STAT3 inhibition on human glioma c... DisGeNET Detail
These data suggest that aberrant activation of STAT-3, which is observed in malignant brain tumors, ... DisGeNET Detail
Furthermore, we revealed that STAT3 was required to maintain SCLIP stability, suggesting that overex... DisGeNET Detail
Collectively, our findings showed how FoxM1 activates expression of PDGF-A and STAT3 in a pathway re... DisGeNET Detail
STAT3 Blockade Inhibits Radiation-Induced Malignant Progression in Glioma. DisGeNET Detail
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Moreover, the protein levels of VEGF, phosphorylated STAT3, total STAT3 and Bcl-2 were significantly... DisGeNET Detail
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Hepatitis C virus represses the cellular antiviral response by upregulating the expression of signal... DisGeNET Detail
We found that, like two other herpesviruses, EBV and HSV-1, KSHV exploits the cellular transcription... DisGeNET Detail
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The JAK/STAT3 pathway is a common inducer of astrocyte reactivity in Alzheimer's and Huntington's di... DisGeNET Detail
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These data suggest that the STAT3 locus is associated with both IBD and cancer. DisGeNET Detail
Therefore, mTORC1 signaling critically protects against inflammatory bowel disease through modulatio... DisGeNET Detail
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Recently, mutations in STAT1, STAT5B, and STAT3 have been linked to development of immunodysregulati... DisGeNET Detail
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Here, we report the characterization of STAT3 protein regulation by STAT3-interacting protein (STATI... DisGeNET Detail
STAT3-activated GM-CSFRα translocates to the nucleus and protects CLL cells from apoptosis. DisGeNET Detail
Furthermore, STAT3 activity contributes to the resistance to apoptosis of CLL, but not normal B cell... DisGeNET Detail
IL-6, IL-10, c-Jun and STAT3 expression in B-CLL. DisGeNET Detail
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STAT3 as a possible therapeutic target in human malignancies: lessons from acute myeloid leukemia. DisGeNET Detail
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Combined STAT3 and BCR-ABL1 inhibition induces synthetic lethality in therapy-resistant chronic myel... DisGeNET Detail
Inhibition of STAT3-interacting protein 1 (STATIP1) promotes STAT3 transcriptional up-regulation and... DisGeNET Detail
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In the present study, Poly I:C (PIC, a TLR3 agonist), STAT3 siRNA and OVA antigen were co-encapsulat... DisGeNET Detail
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Effects of mTOR-STAT3 on the migration and invasion abilities of hepatoma cell and mTOR-STAT3 expres... DisGeNET Detail
Antitumor progression potential of morusin suppressing STAT3 and NFκB in human hepatoma SK-Hep1 cell... DisGeNET Detail
These results indicate that PML modulates IL-6-induced STAT3 activation and hepatoma cell growth by ... DisGeNET Detail
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Liuweibuqi capsules can improve the symptoms of COPD possibly by regulating the expression of the JA... DisGeNET Detail
Consistently, KRAS mutant lung tumours exhibit reduced STAT3 levels. DisGeNET Detail
Stat3 promotes IL-10 expression in lupus T cells through trans-activation and chromatin remodeling. DisGeNET Detail
Stat3 promotes IL-10 expression in lupus T cells through trans-activation and chromatin remodeling. DisGeNET Detail
However, this deficit was not primarily at the signaling or the transcriptional level, because IL-21... DisGeNET Detail
Stat3 promotes IL-10 expression in lupus T cells through trans-activation and chromatin remodeling. DisGeNET Detail
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Activating mutations of STAT5B and STAT3 in lymphomas derived from γδ-T or NK cells. DisGeNET Detail
Effect of STAT3 inhibition on the metabolic switch in a highly STAT3-activated lymphoma cell line. DisGeNET Detail
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ChIP, Co-IP and ChIP-re-IP analysis revealed that ISL-1 could participate with p-STAT3 and p-c-Jun t... DisGeNET Detail
Minor salivary glands (MSGs) from patients with pSS and non-specific chronic sialoadenitis (nSCS), p... DisGeNET Detail
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Silibinin inhibits proliferation, induces apoptosis and causes cell cycle arrest in human gastric ca... DisGeNET Detail
Piperine inhibits IL-1β-induced IL-6 expression by suppressing p38 MAPK and STAT3 activation in gast... DisGeNET Detail
Combinatorial targeting on both HER2 and STAT3 may enhance the efficacy of trastuzumab or other HER2... DisGeNET Detail
Correlation of RKIP, STAT3 and cyclin D1 expression in pathogenesis of gastric cancer. DisGeNET Detail
Taken together, these findings indicate that down-regulation of miR-874 contributes to tumor angioge... DisGeNET Detail
Thus, dual use of STAT3 and GSK-3β inhibitors may enhance the efficacy of the anti-metastatic treatm... DisGeNET Detail
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Taken together, these findings indicate LY5 inhibits persistent and inducible STAT3 phosphorylation ... DisGeNET Detail
Critical role of STAT3 in melanoma metastasis through anoikis resistance. DisGeNET Detail
FAD104 interacted with STAT3 and down-regulated the phosphorylation level of STAT3 in melanoma cells... DisGeNET Detail
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STAT3 downregulation with siRNA or enhanced expression of PIAS3 both inhibited mesothelioma cell gro... DisGeNET Detail
Here we explore whether STAT3 common variations influence risks of obesity and other metabolic disor... DisGeNET Detail
Using immunohistochemistry, IL-6, JAK1, JAK2 and STAT3 were detected significantly more frequently i... DisGeNET Detail
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Down-regulation of interleukin 6 (IL6) by berberine might lead to inhibition of miR-21 transcription... DisGeNET Detail
Evaluation of human MM samples revealed recurrent activation of STAT3, a downstream target of GP130 ... DisGeNET Detail
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Autoimmunity, hypogammaglobulinemia, lymphoproliferation, and mycobacterial disease in patients with... DisGeNET Detail
These results demonstrate that central mediators of immune responses like STAT1 and STAT3 not only d... DisGeNET Detail
Mutations affecting the STAT3/interleukin 17 (IL-17) pathway cause selective susceptibility to funga... DisGeNET Detail
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Our results demonstrate that JAK-STAT3-mediated cytokine production from malignant and nonmalignant ... DisGeNET Detail
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These findings identify CXCR7-mediated STAT3 activation and modulation of the tumor microenvironment... DisGeNET Detail
But the exact molecular mechanism on metastasis is still not fully understood; we now report that bo... DisGeNET Detail
mTORSTAT3 expression in hepatoma cells HepG2 was significantly higher than that in normal liver cell... DisGeNET Detail
Critical role of STAT3 in melanoma metastasis through anoikis resistance. DisGeNET Detail
ACA is a novel drug candidate for the inhibition of tumor metastasis through interference with the S... DisGeNET Detail
Our findings suggest that activation of the JAK2/STAT3 pathway via CXCL12-CXCR4 signaling plays an i... DisGeNET Detail
Our study suggested a novel role for CD8(+) T cells in constraining myeloid cell activity through di... DisGeNET Detail
In conclusion, these data suggest that RKIP inhibits gastric cancer metastasis via the downregulatio... DisGeNET Detail
In conclusion, JAk2/STAT3 plays a key role in CCR7 regulating SCCHN metastasis. DisGeNET Detail
Taken together, our results established the critical involvement of STAT3 in conferring anoikis resi... DisGeNET Detail
Activated STAT3, Twist, and EMT markers may serve as potential molecular targets in the prevention a... DisGeNET Detail
Fad104, a positive regulator of adipocyte differentiation, suppresses invasion and metastasis of mel... DisGeNET Detail
Cytoplasmic p27 promotes epithelial-mesenchymal transition and tumor metastasis via STAT3-mediated T... DisGeNET Detail
The transcription factor signal transducers and activators of transcription 3 (STAT3) can promote ca... DisGeNET Detail
In summary, our study show for the first time that STAT3 activation may induce invasion and metastas... DisGeNET Detail
Leukemia inhibitory factor promotes tumor growth and metastasis in human osteosarcoma via activating... DisGeNET Detail
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Association of STAT3 common variations with obesity and hypertriglyceridemia: protective and contrib... DisGeNET Detail
Together, our results show how targeting STAT3-G9a signaling regulates CSC plasticity during obesity... DisGeNET Detail
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Efficacy of the FLLL32 pharmacological inhibitor in delaying OS growth suggests that targeting JAK2/... DisGeNET Detail
Leukemia inhibitory factor promotes tumor growth and metastasis in human osteosarcoma via activating... DisGeNET Detail
Altogether, our results demonstrate that targeting JAK1/STAT3, using shRNA knockdown or a small-mole... DisGeNET Detail
Ginsenoside 20(S)‑Rg3 inhibits the Warburg effect through STAT3 pathways in ovarian cancer cells. DisGeNET Detail
Synergistic effects of eukaryotic co-expression plasmid-based STAT3-specific siRNA and LKB1 on ovari... DisGeNET Detail
Targeted Blockade of JAK/STAT3 Signaling Inhibits Ovarian Carcinoma Growth. DisGeNET Detail
Here, we report results that may explain this outcome, based on the finding that neutralizing antibo... DisGeNET Detail
STAT3 Decoy Oligodeoxynucleotides-Loaded Solid Lipid Nanoparticles Induce Cell Death and Inhibit Inv... DisGeNET Detail
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STAT3 upregulation in pituitary somatotroph adenomas induces growth hormone hypersecretion. DisGeNET Detail
Evaluation of pituitary tumors revealed that STAT3 expression was enhanced in human GH-secreting ade... DisGeNET Detail
Induction of STAT3-Dependent CXCL5 Expression and Neutrophil Recruitment by Oncostatin-M during Pneu... DisGeNET Detail
Taken together, induction of liver STAT3-dependent gene expression programs is essential to counteri... DisGeNET Detail
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We observed that STAT3 CG and GG genotypes were significantly associated with RHD (p=0.030 and p=0.0... DisGeNET Detail
Oncovirus Kaposi sarcoma herpesvirus (KSHV) represses tumor suppressor PDLIM2 to persistently activa... DisGeNET Detail
STAT3 Regulates Lytic Activation of Kaposi's Sarcoma-Associated Herpesvirus. DisGeNET Detail
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Collectively, these findings demonstrate that Zn deficiency enhances the acute phase response throug... DisGeNET Detail
Interruption of macrophage-derived IL-27(p28) production by IL-10 during sepsis requires STAT3 but n... DisGeNET Detail
Taken together, induction of liver STAT3-dependent gene expression programs is essential to counteri... DisGeNET Detail
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RKIP, STAT3 and cyclin D1 proteins were detected by immunohistochemistry in tissues of gastric ulcer... DisGeNET Detail
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SOCS3 and STAT3, major controllers of the outcome of infection with Mycobacterium tuberculosis. DisGeNET Detail
Furthermore, BEX2 was also increased in the liver of a hepatic specific Pten knock-out mouse and the... DisGeNET Detail
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Clinical implications of phosphorylated STAT3 expression in De Novo diffuse large B-cell lymphoma. DisGeNET Detail
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Here we report frequent activating mutations of STAT3 and STAT5B in NK/T-cell lymphomas (n=51), γδ-T... DisGeNET Detail
Receptor-type tyrosine-protein phosphatase κ directly targets STAT3 activation for tumor suppression... DisGeNET Detail
Constitutive activation of STAT5 and STAT3 was observed in early and late stages of CTCL, respective... DisGeNET Detail
STAT3 knock-down cells and PL treated cells did not form tumors as well as failed to metastasize in ... DisGeNET Detail
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Our findings imply that the clonal landscape of large granular lymphocytic leukemia is more complex ... DisGeNET Detail
The interleukin-6 (IL-6)/Janus kinase (JAK)/signal transducer and activator of transcription 3 (STAT... DisGeNET Detail
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In the present report we examine the status of an endogenous inhibitor of STAT3, called Protein Inhi... DisGeNET Detail
PARD3 Inactivation in Lung Squamous Cell Carcinomas Impairs STAT3 and Promotes Malignant Invasion. DisGeNET Detail
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IL-22R1 expression on PBMC of pSS was functional, as its stimulation with recombinant IL-22 signific... DisGeNET Detail
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Topical application of the JAK inhibitor suppressed STAT3 activation and improved skin barrier funct... DisGeNET Detail
Knockdown of STAT3 in xenografted human AC cells increases tumour growth. DisGeNET Detail
AURKA regulates JAK2-STAT3 activity in human gastric and esophageal cancers. DisGeNET Detail
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We have reported that basic fibroblast growth factor (bFGF) demonstrates an intimate connection with... DisGeNET Detail
These data suggest that aberrant activation of STAT-3, which is observed in malignant brain tumors, ... DisGeNET Detail
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For neonatal diabetes, the use of these technologies has resulted in the identification of 2 novel d... DisGeNET Detail
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Convergent mutations and kinase fusions lead to oncogenic STAT3 activation in anaplastic large cell ... DisGeNET Detail
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We have characterized a novel immunosuppressant, which shows potential anti-tumor effects on CC via ... DisGeNET Detail
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STAT3 induces anoikis resistance, promotes cell invasion and metastatic potential in pancreatic canc... DisGeNET Detail
MiR-1181 inhibits stem cell-like phenotypes and suppresses SOX2 and STAT3 in human pancreatic cancer... DisGeNET Detail
Thus, inhibition of HIF-1α and Stat3 is a potential therapeutic strategy for pancreatic cancer. DisGeNET Detail
Collectively, our results provide the first evidence for the presence of the synergistic effect of R... DisGeNET Detail
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PS2 knockout mice and PS2 knockdown lung cancer cells showed increased DNA-binding activities of nuc... DisGeNET Detail
IL6 signaling was blocked with antibodies against IL6, soluble glycoprotein 130 Fc fragments, and th... DisGeNET Detail
STAT3 is considered to play an oncogenic role in several malignancies including lung cancer; consequ... DisGeNET Detail
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Collectively, these findings demonstrate that Zn deficiency enhances the acute phase response throug... DisGeNET Detail
Interruption of macrophage-derived IL-27(p28) production by IL-10 during sepsis requires STAT3 but n... DisGeNET Detail
Taken together, induction of liver STAT3-dependent gene expression programs is essential to counteri... DisGeNET Detail
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NA DisGeNET Detail
Pneumonia alone (without endotoxemia) was effectively controlled in the absence of liver STAT3. DisGeNET Detail
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Our findings implicate STAT3 as a critical signaling node in BCR-ABL1 kinase-independent TKI resista... DisGeNET Detail
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Effects of mTOR-STAT3 on the migration and invasion abilities of hepatoma cell and mTOR-STAT3 expres... DisGeNET Detail
We proposed that PKM2 activates transcription of hypoxia inducible factor-1α (HIF-1α) by phosphoryla... DisGeNET Detail
JAK2 inhibitor blocks the inflammation and growth of esophageal squamous cell carcinoma in vitro thr... DisGeNET Detail
Dasatinib enhances cisplatin sensitivity in human esophageal squamous cell carcinoma (ESCC) cells vi... DisGeNET Detail
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Given that the tumor-promoting inflammation has been previously established in squamous cell carcino... DisGeNET Detail
Expression of MEKK3, survivin and stat3 mRNA was significantly higher in RCCC than in CG (P < 0.01). DisGeNET Detail
Therefore, sugiol is the first compound regulating STAT3 activity via modulation of cancer metabolic... DisGeNET Detail
NA DisGeNET Detail
miR-21 and Let-7a along with STAT3 may prove useful targets for pharmacological intervention for man... DisGeNET Detail
Blockage of PTPRJ promotes cell growth and resistance to 5-FU through activation of JAK1/STAT3 in th... DisGeNET Detail
These results suggest that polymorphisms in STAT2, STAT3 and IFN-γ genes are not likely to be strong... DisGeNET Detail
The migration and invasion abilities of cells and expression of STAT3 were detected by scratch adhes... DisGeNET Detail
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CCR7 regulates cell migration and invasion through JAK2/STAT3 in metastatic squamous cell carcinoma ... DisGeNET Detail
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The STAT3 inhibitor WP1066 synergizes with vorinostat to induce apoptosis of mantle cell lymphoma ce... DisGeNET Detail
Expression of early growth response 1 affects miR-106a/signal transducer and activator of transcript... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
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NA DisGeNET Detail
Effects of mTOR-STAT3 on the migration and invasion abilities of hepatoma cell and mTOR-STAT3 expres... DisGeNET Detail
We proposed that PKM2 activates transcription of hypoxia inducible factor-1α (HIF-1α) by phosphoryla... DisGeNET Detail
Low PIAS3 expression in malignant mesothelioma is associated with increased STAT3 activation and poo... DisGeNET Detail
STAT3 upregulation in pituitary somatotroph adenomas induces growth hormone hypersecretion. DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
STAT3 induces anoikis resistance, promotes cell invasion and metastatic potential in pancreatic canc... DisGeNET Detail
MiR-1181 inhibits stem cell-like phenotypes and suppresses SOX2 and STAT3 in human pancreatic cancer... DisGeNET Detail
Thus, inhibition of HIF-1α and Stat3 is a potential therapeutic strategy for pancreatic cancer. DisGeNET Detail
Collectively, our results provide the first evidence for the presence of the synergistic effect of R... DisGeNET Detail
NA DisGeNET Detail
Activation of the interleukin-6/Janus kinase/STAT3 pathway in pleomorphic adenoma of the parotid gla... DisGeNET Detail
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Jak1/Stat3 is an upstream signaling of NF-κB activation in Helicobacter pylori-induced IL-8 producti... DisGeNET Detail
Prostate cancer is frequently associated with elevated levels of interleukin-6 (IL-6), which exerts ... DisGeNET Detail
This data suggests that targeting both tumor initiating and differentiated cell populations by STAT3... DisGeNET Detail
Activation of proliferation promoting signaling pathways (including β-catenin, cMyc, NF-κB, STAT1, S... DisGeNET Detail
Genome-wide methylation analysis showed differential methylation in several key signalling pathways ... DisGeNET Detail
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Chronic mucocutaneous candidiasis (CMC) and hyper-IgE syndrome (HIES) are primary immunodeficiencies... DisGeNET Detail
HIES are a group of primary immunodeficiencies with overlapping and distinct features, most frequent... DisGeNET Detail
NA DisGeNET Detail
Stat3 promotes IL-10 expression in lupus T cells through trans-activation and chromatin remodeling. DisGeNET Detail
IL6/JAK1/STAT3 Signaling Blockade in Endometrial Cancer Affects the ALDHhi/CD126+ Stem-like Componen... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
In this study, we examined whether the JAK/STAT3 pathway promotes astrocyte reactivity in several an... DisGeNET Detail
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AURKA regulates JAK2-STAT3 activity in human gastric and esophageal cancers. DisGeNET Detail
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To investigate the regulatory effect of curcumin on expression of signal transducer and activator of... DisGeNET Detail
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Efficacy of the FLLL32 pharmacological inhibitor in delaying OS growth suggests that targeting JAK2/... DisGeNET Detail
Leukemia inhibitory factor promotes tumor growth and metastasis in human osteosarcoma via activating... DisGeNET Detail
ERp57 modulates STAT3 activity in radioresistant laryngeal cancer cells and serves as a prognostic m... DisGeNET Detail
In our study, we examined a new therapeutic alternative in the treatment of multiresistant lung aden... DisGeNET Detail
Although the role of STAT3 and wild-type NPM in oncogenesis has been extensively investigated, the r... DisGeNET Detail
Functionally, RRAD contributes to the activation of STAT3 and expression of the stem cell factors OC... DisGeNET Detail
This study aimed to investigate the correlation of RKIP, STAT3 and cyclin D1 expression in the tumor... DisGeNET Detail
Sphingosine-1-phosphate lyase downregulation promotes colon carcinogenesis through STAT3-activated m... DisGeNET Detail
The present study aimed to investigate the role of the JAK/STAT3 pathway in the growth and cancer-re... DisGeNET Detail
HIF-1α and Stat3 function cooperatively to regulate a number of downstream genes that are implicated... DisGeNET Detail
Oncovirus Kaposi sarcoma herpesvirus (KSHV) represses tumor suppressor PDLIM2 to persistently activa... DisGeNET Detail
Suppressor of cytokine signaling 3 (SOCS3) is a major negative regulator of signal transducer and ac... DisGeNET Detail
In this review, we focus on the role of STAT3 in tumorigenesis, and discuss its potential as a thera... DisGeNET Detail
Overall, our study suggests that the microRNAs, miR-21 and let-7a function as clinically relevant in... DisGeNET Detail
The interleukin-6 (IL-6)/Janus kinase (JAK)/signal transducer and activator of transcription 3 (STAT... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
Prostate cancer is frequently associated with elevated levels of interleukin-6 (IL-6), which exerts ... DisGeNET Detail
This data suggests that targeting both tumor initiating and differentiated cell populations by STAT3... DisGeNET Detail
Activation of proliferation promoting signaling pathways (including β-catenin, cMyc, NF-κB, STAT1, S... DisGeNET Detail
Genome-wide methylation analysis showed differential methylation in several key signalling pathways ... DisGeNET Detail
Thus, while JAK2 V617F is uncommon in de novo AML and probably does not occur in lymphoid malignancy... DisGeNET Detail
Janus kinase 2 (V617F) mutation status, signal transducer and activator of transcription-3 phosphory... DisGeNET Detail
Targeted Blockade of JAK/STAT3 Signaling Inhibits Ovarian Carcinoma Growth. DisGeNET Detail
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The efficiency of PEI/STAT3-siRNA polyplexes in the induction of STAT3 associated cell death in wild... DisGeNET Detail
Drug-repositioning screening identified piperlongumine as a direct STAT3 inhibitor with potent activ... DisGeNET Detail
These findings identify CXCR7-mediated STAT3 activation and modulation of the tumor microenvironment... DisGeNET Detail
Obatoclax analog SC-2001 inhibits STAT3 phosphorylation through enhancing SHP-1 expression and induc... DisGeNET Detail
MRTF-A and STAT3 synergistically promote breast cancer cell migration. DisGeNET Detail
After adjustment for multiple comparisons, JAK1 (three of ten SNPs) and JAK2 (4 of 11 SNPs) interact... DisGeNET Detail
rhIL-24 circumvented the drug-resistance of MCF-7/ADM cells via activation of the transcription fact... DisGeNET Detail
In human breast cancer MCF-7 cells, ER stress activator tunicamycin increased the expression of CCL5... DisGeNET Detail
Zerumbone suppresses EGF-induced CD44 expression through the inhibition of STAT3 in breast cancer ce... DisGeNET Detail
Signal transducer and activator of transcription 3 (STAT3) is implicated breast cancer metastasis an... DisGeNET Detail
Activation of STAT3 is involved in malignancy mediated by CXCL12-CXCR4 signaling in human breast can... DisGeNET Detail
These results provide preclinical evidence to continue the development of alantolactone as a STAT3 i... DisGeNET Detail
This study disclosed concomitant expression of TAMs marker-CD163 with SOX2 in human breast cancer an... DisGeNET Detail
Signal transducer and activator of transcription 3 (STAT3) has been linked to breast cancer progress... DisGeNET Detail
STAT3 genetic variant, alone and in combination with STAT5b polymorphism, contributes to breast canc... DisGeNET Detail
Notch1 induces epithelial-mesenchymal transition and the cancer stem cell phenotype in breast cancer... DisGeNET Detail
Crispene E, a cis-clerodane diterpene inhibits STAT3 dimerization in breast cancer cells. DisGeNET Detail
JSI-124 (Cucurbitacin I) inhibits tumor angiogenesis of human breast cancer through reduction of STA... DisGeNET Detail
Together, our results show how targeting STAT3-G9a signaling regulates CSC plasticity during obesity... DisGeNET Detail
Signal transducer and activator of transcription 3 and 5 regulate system Xc- and redox balance in hu... DisGeNET Detail
STAT3 and STAT5b polymorphism contributes to breast cancer risk and clinical outcomes. DisGeNET Detail
Recently, signal transducer and activator of transcription 3 (STAT3) activation has been linked to E... DisGeNET Detail
Janus kinase 2 (V617F) mutation status, signal transducer and activator of transcription-3 phosphory... DisGeNET Detail
PS2 knockout mice and PS2 knockdown lung cancer cells showed increased DNA-binding activities of nuc... DisGeNET Detail
IL6 signaling was blocked with antibodies against IL6, soluble glycoprotein 130 Fc fragments, and th... DisGeNET Detail
STAT3 is considered to play an oncogenic role in several malignancies including lung cancer; consequ... DisGeNET Detail
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The immunohistochemistry results also showed that the phosphorylation of STAT3 was correlated with C... DisGeNET Detail
In NSCLC, the expression levels of miR-124 and STAT3 correlated significantly with the tumor node me... DisGeNET Detail
Silibinin inhibits proliferation, induces apoptosis and causes cell cycle arrest in human gastric ca... DisGeNET Detail
Piperine inhibits IL-1β-induced IL-6 expression by suppressing p38 MAPK and STAT3 activation in gast... DisGeNET Detail
Combinatorial targeting on both HER2 and STAT3 may enhance the efficacy of trastuzumab or other HER2... DisGeNET Detail
Correlation of RKIP, STAT3 and cyclin D1 expression in pathogenesis of gastric cancer. DisGeNET Detail
Taken together, these findings indicate that down-regulation of miR-874 contributes to tumor angioge... DisGeNET Detail
Thus, dual use of STAT3 and GSK-3β inhibitors may enhance the efficacy of the anti-metastatic treatm... DisGeNET Detail
Urothelial bladder carcinoma displayed elevated expression as well as activation of NF-κB (P = 5.38e... DisGeNET Detail
Cell cycle-defective phosphomimetic p27T157DT198D (p27CK-DD) activates STAT3 to induce a TWIST1-depe... DisGeNET Detail
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We have reported that basic fibroblast growth factor (bFGF) demonstrates an intimate connection with... DisGeNET Detail
These data suggest that aberrant activation of STAT-3, which is observed in malignant brain tumors, ... DisGeNET Detail
We propose a hypothesis accounting for memory impairment related to MHE: DA-dependent inactivation o... DisGeNET Detail
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Here, we report that H. pylori infection activated the signal transducer and activator of transcript... DisGeNET Detail
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Previous studies showed that downregulation of STAT3 using specific short hairpin RNAs (shRNA) can s... DisGeNET Detail
Taken together, our results show pharmacologic inhibition of the JAK2/STAT3 pathway leads to disrupt... DisGeNET Detail
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Modulation of STAT3 and STAT5 activity rectifies the imbalance of Th17 and Treg cells in patients wi... DisGeNET Detail
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Altogether, our results demonstrate that targeting JAK1/STAT3, using shRNA knockdown or a small-mole... DisGeNET Detail
Ginsenoside 20(S)‑Rg3 inhibits the Warburg effect through STAT3 pathways in ovarian cancer cells. DisGeNET Detail
Synergistic effects of eukaryotic co-expression plasmid-based STAT3-specific siRNA and LKB1 on ovari... DisGeNET Detail
Here, we report results that may explain this outcome, based on the finding that neutralizing antibo... DisGeNET Detail
STAT3 Decoy Oligodeoxynucleotides-Loaded Solid Lipid Nanoparticles Induce Cell Death and Inhibit Inv... DisGeNET Detail
Lastly, we confirmed this IL-6 induction of both STAT3 phosphorylation and HIF1A mRNA expression in ... DisGeNET Detail
In conclusion, JAk2/STAT3 plays a key role in CCR7 regulating SCCHN metastasis. DisGeNET Detail
JAK kinase inhibition abrogates STAT3 activation and head and neck squamous cell carcinoma tumor gro... DisGeNET Detail
NF-κB and stat3 transcription factor signatures differentiate HPV-positive and HPV-negative head and... DisGeNET Detail
Predicted activation for STAT3 mediating gene expression relevant for epithelial cell-to-cell adhere... DisGeNET Detail
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In this study, we found that STAT3 activation induced by EGF was associated significantly with morph... DisGeNET Detail
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Correlation between ERK1 and STAT3 expression and chemoresistance in patients with conventional oste... DisGeNET Detail
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Our results demonstrate that JAK-STAT3-mediated cytokine production from malignant and nonmalignant ... DisGeNET Detail
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Combined, these data show that an IL-10/Janus kinase/signal transducer and activator of transcriptio... DisGeNET Detail
The tumorigenicity of most cases of ALK-positive anaplastic large-cell lymphoma (ALK+ ALCL) is drive... DisGeNET Detail
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Effective down-regulation of signal transducer and activator of transcription 3 (STAT3) by polyplexe... DisGeNET Detail
Furthermore, our results in the clinic revealed that nuclear interaction between ErbB-2 and Stat3 co... DisGeNET Detail
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Taken together, these findings indicate that down-regulation of miR-874 contributes to tumor angioge... DisGeNET Detail
JSI-124 (Cucurbitacin I) inhibits tumor angiogenesis of human breast cancer through reduction of STA... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
The analysis of clonal diversity and therapy responses using STAT3 mutations as a molecular marker i... DisGeNET Detail
Overall, this study suggests that PKM2 overexpression promotes CRC cell migration and cell adhesion ... DisGeNET Detail
Using a unique systems biology approach, we identified JAK1/2-dependent activation of STAT3 as the k... DisGeNET Detail
Genome-wide uncovering of STAT3-mediated miRNA expression profiles in colorectal cancer cell lines. DisGeNET Detail
Therefore, miR-27a could be a useful biomarker for monitoring colorectal cancer development and prog... DisGeNET Detail
Th17-type cytokines, IL-6 and TNF-α synergistically activate STAT3 and NF-kB to promote colorectal c... DisGeNET Detail
This suggests that STAT3 positively regulates β-catenin (at a transcriptional level) and evaluation ... DisGeNET Detail
Inhibition of STAT3/cyclinD1 pathway increased the sensitivity of colorectal cancer cell to chemothe... DisGeNET Detail
Aberrantly expressed Fra-1 by IL-6/STAT3 transactivation promotes colorectal cancer aggressiveness t... DisGeNET Detail
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The constitutive activation of STAT3 in human ovarian cancer cells appeared to be mediated by an aut... DisGeNET Detail
AZD1480 treatment inhibited STAT3 phosphorylation and DNA binding, and migration and adhesion of cul... DisGeNET Detail
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Whereas the ERK1/2 and STAT3 pathways independently promote proliferation and resistance to EGFR and... DisGeNET Detail
Although EGFR phosphorylation and STAT3 activation are essential for the maintenance of GBM cancer s... DisGeNET Detail
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SSD treatment inhibited STAT3 activation [phosphorylation of STAT3 (p‑STAT3)], reduced the protein l... DisGeNET Detail
miR-146a is directly regulated by STAT3 in human hepatocellular carcinoma cells and involved in anti... DisGeNET Detail
STAT3 has many roles in physiological processes such as inflammatory signalling, aerobic glycolysis ... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
IL6/JAK1/STAT3 Signaling Blockade in Endometrial Cancer Affects the ALDHhi/CD126+ Stem-like Componen... DisGeNET Detail
STAT3 mutation was detected in 12% of the cohort, which is lower than the frequency observed in T-LG... DisGeNET Detail
The analysis of clonal diversity and therapy responses using STAT3 mutations as a molecular marker i... DisGeNET Detail
The pathogenesis of T-cell large granular lymphocytic leukemia (T-LGL) is poorly understood, as STAT... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
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High NF-κB and STAT3 activity in human urothelial carcinoma: a pilot study. DisGeNET Detail
A novel miR-219-SMC4-JAK2/Stat3 regulatory pathway in human hepatocellular carcinoma. DisGeNET Detail
Effects of mTOR-STAT3 on the migration and invasion abilities of hepatoma cell and mTOR-STAT3 expres... DisGeNET Detail
Transcriptional regulation of STAT3 by SPTBN1 and SMAD3 in HCC through cAMP-response element-binding... DisGeNET Detail
The iron chelator Dp44mT inhibits hepatocellular carcinoma metastasis via N-Myc downstream-regulated... DisGeNET Detail
Suppression of STAT3 phosphorylation by CIMO and knockdown of STAT3 mRNA using siRNA transfection di... DisGeNET Detail
We found that IL-8: i) may induce EMT and promote HCC cell migration and invasion and ii) is associa... DisGeNET Detail
Antitumor progression potential of morusin suppressing STAT3 and NFκB in human hepatoma SK-Hep1 cell... DisGeNET Detail
STAT3 regulates the migration and invasion of a stem‑like subpopulation through microRNA‑21 and mult... DisGeNET Detail
miR-146a is directly regulated by STAT3 in human hepatocellular carcinoma cells and involved in anti... DisGeNET Detail
Finally, when administered intraperitoneally, ASC also inhibited tumor growth in an orthotopic HCC m... DisGeNET Detail
STAT3 cooperates with Twist to mediate epithelial-mesenchymal transition in human hepatocellular car... DisGeNET Detail
Invasion and migration of HCC cells in vitro were inhibited by both STAT3 and miR-21 antagonists, su... DisGeNET Detail
These results indicate that PML modulates IL-6-induced STAT3 activation and hepatoma cell growth by ... DisGeNET Detail
STAT3 activation mediates epithelial-to-mesenchymal transition in human hepatocellular carcinoma cel... DisGeNET Detail
NA DisGeNET Detail
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Activation of miR-21 by STAT3 induces proliferation and suppresses apoptosis in nasopharyngeal carci... DisGeNET Detail
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Induction of fibronectin in response to epidermal growth factor is suppressed by silibinin through t... DisGeNET Detail
NA DisGeNET Detail
Induction of STAT3-Dependent CXCL5 Expression and Neutrophil Recruitment by Oncostatin-M during Pneu... DisGeNET Detail
Taken together, induction of liver STAT3-dependent gene expression programs is essential to counteri... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
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Together, these results indicate that adenoma GH hypersecretion is the result of STAT3-dependent GH ... DisGeNET Detail
NA DisGeNET Detail
Here we show that the Humanin signaling pathway via htHNR/JAKs/STAT3 increased the expression levels... DisGeNET Detail
The JAK/STAT3 pathway was activated in reactive astrocytes in two transgenic mouse models of Alzheim... DisGeNET Detail
We propose a hypothesis accounting for memory impairment related to MHE: DA-dependent inactivation o... DisGeNET Detail
Germline loss-of-function mutations in the transcription factor signal transducer and activator of t... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
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This is the first study to provide evidence of a functional link between HIF1α, STAT3 and Notch-1 si... DisGeNET Detail
Treatment with an approved TNFα blocking antibody showed marked reduction in the levels of IL-6, IL-... DisGeNET Detail
CD4 T-cell transcriptome analysis reveals aberrant regulation of STAT3 and Wnt signaling pathways in... DisGeNET Detail
NA DisGeNET Detail
STAT-3 knockdown decreased OSM-mediated expression of ADM, indicating that ADM expression is regulat... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
Interleukin-23 receptor (IL-23R) and signal transducer and activator of transcription 3 (STAT3) poly... DisGeNET Detail
T-helper 17 (Th17) cells, a recently identified CD4+ T subset with a unique characteristic to produc... DisGeNET Detail
Recently, germline mutations in STAT3 have also been associated with autoimmune disease. DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
Basal US total STAT3 expression was significantly higher in BD (1.2 vs 3.45, P < 0.05). DisGeNET Detail
Expression of IL-6, Foxa2, and phosphorylated signal transducer activator of transcription 3 (STAT3)... DisGeNET Detail
Cell cycle-defective phosphomimetic p27T157DT198D (p27CK-DD) activates STAT3 to induce a TWIST1-depe... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
The efficiency of PEI/STAT3-siRNA polyplexes in the induction of STAT3 associated cell death in wild... DisGeNET Detail
Drug-repositioning screening identified piperlongumine as a direct STAT3 inhibitor with potent activ... DisGeNET Detail
These findings identify CXCR7-mediated STAT3 activation and modulation of the tumor microenvironment... DisGeNET Detail
Obatoclax analog SC-2001 inhibits STAT3 phosphorylation through enhancing SHP-1 expression and induc... DisGeNET Detail
MRTF-A and STAT3 synergistically promote breast cancer cell migration. DisGeNET Detail
After adjustment for multiple comparisons, JAK1 (three of ten SNPs) and JAK2 (4 of 11 SNPs) interact... DisGeNET Detail
rhIL-24 circumvented the drug-resistance of MCF-7/ADM cells via activation of the transcription fact... DisGeNET Detail
In human breast cancer MCF-7 cells, ER stress activator tunicamycin increased the expression of CCL5... DisGeNET Detail
Zerumbone suppresses EGF-induced CD44 expression through the inhibition of STAT3 in breast cancer ce... DisGeNET Detail
Signal transducer and activator of transcription 3 (STAT3) is implicated breast cancer metastasis an... DisGeNET Detail
Activation of STAT3 is involved in malignancy mediated by CXCL12-CXCR4 signaling in human breast can... DisGeNET Detail
These results provide preclinical evidence to continue the development of alantolactone as a STAT3 i... DisGeNET Detail
This study disclosed concomitant expression of TAMs marker-CD163 with SOX2 in human breast cancer an... DisGeNET Detail
Signal transducer and activator of transcription 3 (STAT3) has been linked to breast cancer progress... DisGeNET Detail
STAT3 genetic variant, alone and in combination with STAT5b polymorphism, contributes to breast canc... DisGeNET Detail
Notch1 induces epithelial-mesenchymal transition and the cancer stem cell phenotype in breast cancer... DisGeNET Detail
Crispene E, a cis-clerodane diterpene inhibits STAT3 dimerization in breast cancer cells. DisGeNET Detail
JSI-124 (Cucurbitacin I) inhibits tumor angiogenesis of human breast cancer through reduction of STA... DisGeNET Detail
Together, our results show how targeting STAT3-G9a signaling regulates CSC plasticity during obesity... DisGeNET Detail
Signal transducer and activator of transcription 3 and 5 regulate system Xc- and redox balance in hu... DisGeNET Detail
STAT3 and STAT5b polymorphism contributes to breast cancer risk and clinical outcomes. DisGeNET Detail
Recently, signal transducer and activator of transcription 3 (STAT3) activation has been linked to E... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
Mutations affecting the STAT3/interleukin 17 (IL-17) pathway cause selective susceptibility to funga... DisGeNET Detail
Chronic mucocutaneous candidiasis (CMC) and hyper-IgE syndrome (HIES) are primary immunodeficiencies... DisGeNET Detail
We therefore hypothesized that STAT1 and STAT3 defects have different effects on trained immunity, a... DisGeNET Detail
Gain-of-function STAT1 mutations impair STAT3 activity in patients with chronic mucocutaneous candid... DisGeNET Detail
IL6/JAK1/STAT3 Signaling Blockade in Endometrial Cancer Affects the ALDHhi/CD126+ Stem-like Componen... DisGeNET Detail
ERp57 modulates STAT3 activity in radioresistant laryngeal cancer cells and serves as a prognostic m... DisGeNET Detail
STAT3 knockdown significantly impaired the ability of prostate cancer cells to initiate development ... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
Essential role of aldehyde dehydrogenase 1A3 for the maintenance of non-small cell lung cancer stem ... DisGeNET Detail
Four human non-small cell lung cancer cell lines were treated with epidermal growth factor to evalua... DisGeNET Detail
Reciprocal activation between IL-6/STAT3 and NOX4/Akt signalings promotes proliferation and survival... DisGeNET Detail
The tumor suppressor miR-124 inhibits cell proliferation by targeting STAT3 and functions as a progn... DisGeNET Detail
This study also suggests that STAT3 inhibitors may aid in the treatment NSCLC patients who exhibit E... DisGeNET Detail
Feed-Forward Reciprocal Activation of PAFR and STAT3 Regulates Epithelial-Mesenchymal Transition in ... DisGeNET Detail
NA DisGeNET Detail
Finally, when administered i.p., zerumbone inhibited STAT3 activation in tumor tissues and the growt... DisGeNET Detail

Overlapped Transcript Coordinates

Gene Transcript ID Exon Number Chromosome Start Stop Type Amino Mutation Transcript Position Links

Overlapped Transcript

Gene Transcript ID Chromosome Start Stop Links
Gene
-
dbSNP
rs386626619 dbSNP
Genome
hg38
Position
chr17:42,313,324-42,388,568
Variant Type
snv
Genome browser