Annotation Detail
Information
- Associated Genes
- STAT3
- Associated Variants
-
STAT3 MUTATION
STAT3 MUTATION - Associated Disease
- colorectal cancer
- Source Database
- DisGeNET
- Description
- Using a unique systems biology approach, we identified JAK1/2-dependent activation of STAT3 as the key mediator of resistance to MEK inhibitors in KRASMT CRC in vitro and in vivo.
- Pubmed
- 24931611
- Section of the abstract supporting the evidence
- ALL_TEXT_2/3
- Number of the section of the abstract supporting the evidence
- 2
- Number of the sentence supporting the evidence
- 2
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.0084146980344894
Drugs