chr6:152011631:> Detail (hg19)

Information

Genome

Assembly Position
hg19 chr6:152,011,631-152,450,754
hg38 chr6:151,690,496-152,129,619 

HGVS

Type Transcript Protein
Summary

MGeND

Clinical significance
Variant entry
GWAS entry
Disease area statistics Show details

Frequency

[No Data.]

Prediction

[No Data.]

ClinVar

Clinical Significance
Review star [No Data.]
Show details
Links
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
[No Data.]
CIViC
[No Data.]
DisGeNET
Score Disease name Description Source Pubmed Links
0.001 squamous cell carcinoma NA BeFree Detail
0.003 Carcinoma, Transitional Cell NA BeFree,LHGDN Detail
0.003 Cardiomyopathy, Dilated NA LHGDN Detail
0.005 hypertrophic cardiomyopathy NA GAD,LHGDN Detail
0.025 Cardiovascular Diseases NA BeFree,GAD,LHGDN Detail
0.002 carotid stenosis NA GAD Detail
0.003 carpal tunnel syndrome NA LHGDN Detail
0.120 Neoplastic Cell Transformation NA CTD_human Detail
0.002 cellulitis NA GAD Detail
0.003 cerebral infarction NA BeFree,GAD Detail
0.005 brain ischemia NA GAD Detail
0.080 Transient ischemic attack NA RGD Detail
0.003 Malignant tumor of cervix Activation of G-protein coupled estrogen receptor inhibits the proliferation of ... BeFree 25753185 Detail
0.003 Malignant tumor of cervix Significantly, despite clinical, epidemiological, and animal model results linki... BeFree 26056290 Detail
<0.001 Cervix Diseases NA BeFree Detail
<0.001 Cervical dysplasia Molecular transitions from papillomavirus infection to cervical precancer and ca... BeFree 26056290 Detail
<0.001 cholecystitis Global DNA Methylation Index (p = 0.02) and promoter methylation of SSBP2 (p = 0... BeFree 25066711 Detail
0.003 cholelithiasis NA BeFree,GAD Detail
<0.001 cholera NA BeFree Detail
0.003 cholestasis Taken together, our data indicate that EE2-induced cholestasis increases SHP and... BeFree,GAD 25943116 Detail
<0.001 chordoma NA BeFree Detail
0.002 chorioamnionitis NA GAD Detail
<0.001 choriocarcinoma NA BeFree Detail
0.002 Cognition Disorders NA GAD Detail
<0.001 ulcerative colitis NA BeFree Detail
0.003 Colonic Neoplasms NA BeFree,GAD Detail
0.004 colorectal carcinoma Independent adverse prognostic significance was retained in multivariable analys... BeFree 25970543 Detail
0.012 Colorectal Neoplasms NA BeFree,LHGDN Detail
0.012 Coronary Arteriosclerosis NA BeFree,GAD Detail
0.019 Coronary heart disease NA BeFree,GAD,LHGDN Detail
<0.001 coronary thrombosis NA BeFree Detail
<0.001 craniopharyngioma NA BeFree Detail
0.088 cryptorchidism NA BeFree,GAD,RGD Detail
<0.001 Phyllodes Tumor NA BeFree Detail
<0.001 Cyst NA BeFree Detail
0.002 Sudden death NA GAD Detail
0.002 Presenile dementia NA BeFree Detail
0.003 Dementia, Vascular NA BeFree,GAD Detail
0.001 Mental Depression NA BeFree Detail
0.001 depressive disorder NA BeFree Detail
0.001 Diabetes Several SNPs in MAP3K9 were associated with ER+/PR+ tumors and interacted with d... BeFree 25629224 Detail
0.001 Diabetes Analyses stratified by estrogen receptor status (ER) showed that the diabetes GR... BeFree 25679392 Detail
0.003 diabetes mellitus Several SNPs in MAP3K9 were associated with ER+/PR+ tumors and interacted with d... BeFree,GAD 25629224 Detail
0.003 diabetes mellitus Analyses stratified by estrogen receptor status (ER) showed that the diabetes GR... BeFree,GAD 25679392 Detail
0.080 Diabetes Mellitus, Experimental NA RGD Detail
<0.001 Diabetes Mellitus, Insulin-Dependent NA BeFree Detail
0.080 Diabetic Nephropathy NA BeFree,RGD Detail
0.003 Down syndrome NA BeFree,LHGDN Detail
0.002 drug allergy NA GAD Detail
0.003 Dry Eye Syndromes NA BeFree,GAD Detail
0.002 Dysmenorrhea NA GAD Detail
<0.001 Eating Disorders NA BeFree Detail
<0.001 Experimental Autoimmune Encephalomyelitis NA BeFree Detail
0.002 Endocrine System Diseases NA GAD Detail
<0.001 Endocrine Gland Neoplasms NA BeFree Detail
<0.001 Yolk Sac Tumor NA BeFree Detail
0.162 Endometrial Neoplasms New target genes in endometrial tumors show a role for the estrogen-receptor pat... BeFree,CTD_human,GAD,LHGDN 25231886 Detail
0.004 endometrial hyperplasia NA BeFree,LHGDN Detail
0.064 endometriosis NA BeFree,GAD,LHGDN Detail
<0.001 epidermodysplasia verruciformis NA BeFree Detail
<0.001 epilepsy NA BeFree Detail
<0.001 absence epilepsy However, the absence of clinical history of hormone exposure, predominance of sm... BeFree 25911262 Detail
<0.001 Epithelial hyperplasia NA BeFree Detail
<0.001 peptic esophagitis NA BeFree Detail
0.002 Facial Pain NA GAD Detail
0.120 Feminization NA CTD_human Detail
0.002 Fetal Membranes, Premature Rupture NA GAD Detail
<0.001 breast fibrocystic disease NA BeFree Detail
0.005 Pathological fracture NA GAD Detail
0.002 Genital Neoplasms, Female NA GAD Detail
<0.001 gingivitis NA BeFree Detail
<0.001 Gingivosis NA BeFree Detail
0.005 Glaucoma, Open-Angle NA BeFree,GAD,LHGDN Detail
<0.001 glioblastoma We present data that letrozole, an extensively used aromatase inhibitor in the t... BeFree 25695958 Detail
0.001 Glioma NA BeFree Detail
0.120 glomerulonephritis NA CTD_human Detail
0.002 Graft-vs-Host Disease NA GAD Detail
<0.001 chronic granulomatous disease NA BeFree Detail
0.003 granulosa cell tumor NA BeFree,LHGDN Detail
<0.001 Graves Disease NA BeFree Detail
<0.001 gynecomastia NA BeFree Detail
<0.001 cardiac arrest ECCCs had SCA-like features with rare expression of estrogen receptor/progestero... BeFree 25473756 Detail
0.003 Heart Diseases NA BeFree,GAD Detail
<0.001 Heart failure NA BeFree Detail
<0.001 congestive heart failure NA BeFree Detail
<0.001 hepatitis NA BeFree Detail
<0.001 hepatitis A NA BeFree Detail
0.004 hepatitis B NA BeFree,LHGDN Detail
<0.001 hepatitis C Sex-specific association of estrogen receptor 2 polymorphisms with hepatitis C v... BeFree 25261585 Detail
<0.001 Herpes NOS NA BeFree Detail
<0.001 Herpes Simplex Infections NA BeFree Detail
0.003 Herpes zoster disease NA LHGDN Detail
0.002 Hip Dislocation, Congenital NA GAD Detail
<0.001 HIV Infections NA BeFree Detail
<0.001 hypercalcemia NA BeFree Detail
<0.001 Hypercholesterolemia, Familial NA BeFree Detail
<0.001 hyperglycemia ERβ, VDR and 1OHase expression and activity were inhibited by hyperglycemia, but... BeFree 25448744 Detail
0.003 Hyperlipidemia NA BeFree,GAD Detail
0.002 Immediate hypersensitivity NA GAD Detail
0.014 Hypertensive disease NA BeFree,GAD,LHGDN Detail
<0.001 pulmonary hypertension NA BeFree Detail
0.002 Hypomenorrhea NA GAD Detail
<0.001 Immune System Diseases NA BeFree Detail
0.002 Infant, Premature, Diseases NA GAD Detail
0.082 infertility NA GAD,RGD Detail
0.125 Female infertility NA CTD_human,GAD Detail
0.139 male infertility It is concluded that as oestrogen is concerned in male gamete maturation, ER-α g... BeFree,CTD_human,GAD,LHGDN 23822672 Detail
0.139 male infertility Association of polymorphisms in estrogen receptors (ESR1 and ESR2) with male inf... BeFree,CTD_human,GAD,LHGDN 24647635 Detail
0.001 Mammary Ductal Carcinoma NA BeFree Detail
0.007 Inflammation NA GAD Detail
<0.001 Inflammatory Bowel Diseases NA BeFree Detail
0.002 Insulin resistance NA GAD Detail
0.012 colorectal cancer Our results suggest that the common Leu84Phe and Ile143Val polymorphisms in MGMT... BeFree 16633920 Detail
0.004 colorectal carcinoma Our results suggest that the common Leu84Phe and Ile143Val polymorphisms in MGMT... BeFree 16633920 Detail
<0.001 arthropathy The primary endpoint, 4-variable, 28-joint disease activity score erythrocyte se... BeFree 25359150 Detail
0.001 Kidney Diseases NA BeFree Detail
0.010 Kidney Failure, Chronic NA BeFree,GAD,LHGDN Detail
0.002 Kidney Neoplasm NA GAD Detail
0.002 Premature Obstetric Labor NA GAD Detail
0.162 Fibroid Tumor Our results suggested that both CYP17A1 and ESR1 polymorphisms may modulate the ... BeFree,CTD_human,GAD,LHGDN 25030786 Detail
<0.001 leiomyosarcoma NA BeFree Detail
0.124 leukemia β2-M silencing significantly inhibited Bcl-2 mRNA expression, but did not inhibi... BeFree,CTD_human,GAD 25292288 Detail
0.124 leukemia Mixed lineage leukaemia histone methylases 1 collaborate with ERα to regulate HO... BeFree,CTD_human,GAD 25307539 Detail
<0.001 chronic lymphocytic leukemia NA BeFree Detail
<0.001 Acute lymphocytic leukemia AYA survival was worse for female breast cancer (regardless of estrogen receptor... BeFree 25417236 Detail
<0.001 Leukemia, Lymphocytic, Acute, L1 NA BeFree Detail
0.004 Leukemia, Myelocytic, Acute Mixed lineage leukaemia histone methylases 1 collaborate with ERα to regulate HO... BeFree,LHGDN 25307539 Detail
0.004 Leukemia, Myelocytic, Acute AYA survival was worse for female breast cancer (regardless of estrogen receptor... BeFree,LHGDN 25417236 Detail
<0.001 myeloid leukemia NA BeFree Detail
<0.001 Myeloid Leukemia, Chronic NA BeFree Detail
<0.001 lipodystrophy NA BeFree Detail
0.003 liver cirrhosis NA BeFree,GAD Detail
0.005 Biliary cirrhosis NA GAD,LHGDN Detail
<0.001 Liver diseases NA BeFree Detail
0.124 Liver neoplasms NA BeFree,CTD_human,GAD Detail
<0.001 Lordosis NA BeFree Detail
0.002 Chronic Obstructive Airway Disease NA GAD Detail
0.124 Lung Neoplasms NA BeFree,CTD_human,LHGDN Detail
0.002 Lupus Vulgaris NA BeFree Detail
0.002 Lupus Erythematosus, Discoid NA BeFree Detail
0.019 Lupus Erythematosus, Systemic Meta-analysis of associations of IL1 receptor antagonist and estrogen receptor g... BeFree,GAD,LHGDN 25286391 Detail
0.019 Lupus Erythematosus, Systemic Association of estrogen receptor 1 (ESR1) haplotypes with risk for systemic lupu... BeFree,GAD,LHGDN 26669013 Detail
0.003 lupus nephritis NA BeFree,GAD Detail
<0.001 Lymphatic Metastasis NA BeFree Detail
<0.001 lymphocytic choriomeningitis NA BeFree Detail
0.003 lymphoma NA BeFree,LHGDN Detail
<0.001 Lymphoma, Follicular NA BeFree Detail
0.002 Lymphoma, Non-Hodgkin NA GAD Detail
0.002 Malignant neoplasm of stomach NA BeFree Detail
0.134 Animal Mammary Neoplasms NA CTD_human,GAD Detail
0.200 Mammary Neoplasms, Experimental NA CTD_human,RGD Detail
<0.001 medulloblastoma The role of ESR2 [estrogen receptor (ER)-β] in promoting Med growth was comprehe... BeFree 25885794 Detail
<0.001 melanoma NA BeFree Detail
0.002 meningioma NA BeFree Detail
0.002 premature menopause NA BeFree Detail
0.120 Mesothelioma NA CTD_human Detail
0.003 Metaplasia NA LHGDN Detail
<0.001 Monosomy NA BeFree Detail
<0.001 multiple myeloma NA BeFree Detail
0.004 multiple sclerosis NA BeFree,GAD Detail
0.003 myasthenia gravis NA BeFree,LHGDN Detail
0.267 myocardial infarction NA BeFree,CLINVAR,CTD_human,GAD,LHGDN Detail
0.080 Myocardial Reperfusion Injury NA RGD Detail
<0.001 myoma NA BeFree Detail
<0.001 myopia NA BeFree Detail
0.005 Neoplasm Invasiveness NA GAD Detail
0.163 Neoplasm Metastasis MTDH overexpression was significantly associated with a high nuclear grade, nega... BeFree,CTD_human,LHGDN 22903204 Detail
0.163 Neoplasm Metastasis IL-13Rα2 mediates PNR-induced migration and metastasis in ERα-negative breast ca... BeFree,CTD_human,LHGDN 24747967 Detail
0.163 Neoplasm Metastasis Triple-negative breast cancer (TNBC) is a distinct breast cancer subtype defined... BeFree,CTD_human,LHGDN 24786829 Detail
0.163 Neoplasm Metastasis Conversely, the IFN metagene was associated with a low risk of metastasis in 104... BeFree,CTD_human,LHGDN 24853384 Detail
0.163 Neoplasm Metastasis Significant association was observed between diversin overexpression and TNM sta... BeFree,CTD_human,LHGDN 24858714 Detail
0.163 Neoplasm Metastasis Furthermore, we find that elevated PHLDA1 expression is associated with a higher... BeFree,CTD_human,LHGDN 24954507 Detail
0.163 Neoplasm Metastasis A small, distinct subgroup of the ER negative patients was identified which exhi... BeFree,CTD_human,LHGDN 25141126 Detail
0.163 Neoplasm Metastasis In breast cancer, PR becomes highly correlated with ER, and this convergence is ... BeFree,CTD_human,LHGDN 25261374 Detail
0.163 Neoplasm Metastasis Recurrence or early metastasis remains the predominant cause of mortality in pat... BeFree,CTD_human,LHGDN 25266665 Detail
0.163 Neoplasm Metastasis Tpx2, the most highly connected gene within a proliferation network specifically... BeFree,CTD_human,LHGDN 25368990 Detail
0.163 Neoplasm Metastasis Association of miR-1266 with recurrence/metastasis potential in estrogen recepto... BeFree,CTD_human,LHGDN 25640367 Detail
0.163 Neoplasm Metastasis Benzophenone-1 and nonylphenol stimulated MCF-7 breast cancer growth by regulati... BeFree,CTD_human,LHGDN 25849766 Detail
0.163 Neoplasm Metastasis These results indicate that tamoxifen can significantly accelerate Twist1 degrad... BeFree,CTD_human,LHGDN 25892968 Detail
0.163 Neoplasm Metastasis Early identification of ESR1 mutations by liquid biopsy might allow for cessatio... BeFree,CTD_human,LHGDN 25979954 Detail
0.163 Neoplasm Metastasis For these patients, Sanger sequencing identified four metastases with clear ESR1... BeFree,CTD_human,LHGDN 25994408 Detail
0.163 Neoplasm Metastasis MicroRNAs associated with the development of distant metastasis were identified ... BeFree,CTD_human,LHGDN 26057454 Detail
0.163 Neoplasm Metastasis Autocrine human growth hormone stimulates the tumor initiating capacity and meta... BeFree,CTD_human,LHGDN 26070963 Detail
0.163 Neoplasm Metastasis In 224 adjuvant hormonal treatment-naïve estrogen receptor (ER, ESR1)-positive p... BeFree,CTD_human,LHGDN 26251419 Detail
0.163 Neoplasm Metastasis Effect of fenhexamid and cyprodinil on the expression of cell cycle- and metasta... BeFree,CTD_human,LHGDN 26344002 Detail
0.163 Neoplasm Metastasis Higher gelsolin expression correlated with lower tumor stage and grade, and slow... BeFree,CTD_human,LHGDN 26408687 Detail
0.120 Neoplasm Recurrence, Local NA CTD_human Detail
0.001 nephroblastoma NA BeFree Detail
0.003 neuroblastoma NA BeFree Detail
<0.001 Nodule Both Esr1 and CYP19A1 overexpressing mice responded to letrozole with reduced hy... BeFree 25421723 Detail
0.229 obesity Estrogen receptor (ER)α-regulated lipocalin 2 expression in adipose tissue links... BeFree,CTD_human,GAD,RGD 25468909 Detail
0.229 obesity Obesity is associated with a worse breast cancer prognosis, particularly in estr... BeFree,CTD_human,GAD,RGD 25476497 Detail
0.229 obesity Obesity is associated with altered methylation overall, and with hypermethylatio... BeFree,CTD_human,GAD,RGD 25583948 Detail
0.229 obesity These results suggest that adipocytes can modify breast cancer cell ER gene expr... BeFree,CTD_human,GAD,RGD 25823469 Detail
0.229 obesity Being highly obese, however, was inversely associated with ESR1 expression (adju... BeFree,CTD_human,GAD,RGD 25884832 Detail
0.003 Obesity, Morbid NA BeFree,GAD Detail
<0.001 obsessive-compulsive disorder NA BeFree Detail
0.125 oligospermia NA CTD_human,GAD Detail
0.008 Osteoarthritis of hip NA BeFree,GAD,LHGDN Detail
<0.001 osteochondritis dissecans NA BeFree Detail
0.002 Bone necrosis NA GAD Detail
0.154 osteoporosis These genes all displayed estradiol (E2)-dependent induction in human fetal oste... BeFree,GAD,LHGDN,RGD 25148458 Detail
0.040 Osteoporosis, Postmenopausal NA BeFree,GAD,LHGDN Detail
0.005 osteosarcoma In this study, OS cell MG-63 was treated with low (1 nM) or high (100 nM) dose o... BeFree,LHGDN 25592968 Detail
0.018 ovarian carcinoma Inhibitory effects of aromatase inhibitor on estrogen receptor-alpha positive ov... BeFree 24410765 Detail
0.018 ovarian carcinoma Importantly, this BTB mediated inhibition of ER activity is selective since BTB ... BeFree 25221777 Detail
0.018 ovarian carcinoma BRCA mutations were detected in 26 of 92 patients (28%) with ovarian cancer, in ... BeFree 25236687 Detail
0.018 ovarian carcinoma E2-ERα activates all three arms of the UPR in breast and ovarian cancer cells in... BeFree 25263449 Detail
0.018 ovarian carcinoma The mRNA level for FOXP1 and ERβ in ovarian carcinoma tissues decreased, while t... BeFree 25500588 Detail
0.018 ovarian carcinoma Using screening and functional validation, we identified BHPI, a potent noncompe... BeFree 25825714 Detail
0.018 ovarian carcinoma Effect of fenhexamid and cyprodinil on the expression of cell cycle- and metasta... BeFree 26344002 Detail
<0.001 Ovarian Cysts NA BeFree Detail
<0.001 Ovarian Diseases NA BeFree Detail
<0.001 Pain Thus, we sought to determine the effects of polymorphisms in COMT and functional... BeFree 25218601 Detail
<0.001 papilloma Early stage of BC demonstrated higher HPV positivity, and BC positive for estrog... BeFree 24858917 Detail
<0.001 Parathyroid Neoplasms NA BeFree Detail
0.005 Parkinson disease NA BeFree,GAD Detail
0.005 periodontitis NA BeFree,GAD Detail
0.120 Peripheral neuropathy NA CTD_human Detail
0.080 peritonitis NA RGD Detail
0.002 pituitary adenoma NA BeFree Detail
0.003 Pituitary Diseases NA BeFree Detail
0.004 Pituitary Neoplasms NA BeFree,LHGDN Detail
0.080 pleurisy NA BeFree,RGD Detail
0.004 polycystic ovary syndrome Estrogen receptor αlpha gene (ESR1) PvuII and XbaI polymorphisms are associated ... BeFree,GAD 25617525 Detail
<0.001 polymyalgia rheumatica NA BeFree Detail
0.005 Adenomatous Polyposis Coli NA BeFree,LHGDN Detail
0.012 pre-eclampsia NA GAD,LHGDN Detail
0.003 Precancerous Conditions NA BeFree,GAD Detail
0.003 Premenstrual syndrome Effect of estrogen receptor gene ESR1 polymorphism on development of premenstrua... BeFree,GAD 25416214 Detail
0.001 prolactinoma NA BeFree Detail
0.140 Prostatic Neoplasms NA BeFree,CTD_human,GAD,LHGDN Detail
<0.001 psoriasis US abnormalities were independent of ePsA clinical indices (except erosions - ev... BeFree 25797649 Detail
<0.001 Tension Headache NA BeFree Detail
0.120 Psychoses, Substance-Induced NA CTD_human Detail
0.002 Psychotic Disorders NA GAD Detail
0.004 Precocious Puberty NA BeFree,LHGDN Detail
<0.001 kidney failure NA BeFree Detail
0.002 retinoblastoma NA BeFree Detail
0.003 retinopathy of prematurity NA BeFree,GAD Detail
<0.001 rhabdomyosarcoma NA BeFree Detail
0.017 schizophrenia NA BeFree,GAD,LHGDN Detail
0.003 systemic scleroderma NA BeFree,GAD Detail
0.012 Scoliosis, unspecified NA BeFree,GAD,LHGDN Detail
<0.001 Seizures NA BeFree Detail
<0.001 seminoma NA BeFree Detail
<0.001 Shared Paranoid Disorder NA BeFree Detail
0.080 Shock, Hemorrhagic NA RGD Detail
<0.001 ankylosing spondylitis Reverse transcription-polymerase chain reaction (RT-PCR), flow cytometry, and en... BeFree 25005770 Detail
0.003 Stomach Neoplasms NA BeFree,LHGDN Detail
0.019 Cerebrovascular accident NA BeFree,GAD Detail
0.080 Subarachnoid Hemorrhage NA RGD Detail
<0.001 Giant Cell Arteritis NA BeFree Detail
0.010 Temporomandibular Joint Disorders NA BeFree,GAD Detail
<0.001 teratoma NA BeFree Detail
<0.001 Thromboembolism NA BeFree Detail
0.002 thrombosis NA GAD Detail
<0.001 thymoma NA BeFree Detail
<0.001 Thymus Hyperplasia NA BeFree Detail
0.006 Thyroid Neoplasm NA BeFree,GAD,LHGDN Detail
0.002 Tobacco use disorder NA GAD Detail
0.003 trigeminal neuralgia An unexpected finding concerns the relatively high numbers of ER-positive and no... BeFree,GAD 25277734 Detail
0.001 Unipolar Depression NA BeFree Detail
0.080 Urination Disorders NA RGD Detail
0.003 Uterine Diseases NA BeFree,GAD Detail
0.011 Uterine Fibroids Our results suggested that both CYP17A1 and ESR1 polymorphisms may modulate the ... BeFree 25030786 Detail
0.012 Uterine Neoplasms NA BeFree,GAD Detail
0.002 Uterine Prolapse NA GAD Detail
0.005 Varicose Ulcer NA BeFree,GAD Detail
<0.001 Varicosity NA BeFree Detail
0.003 Vascular Diseases NA BeFree,GAD Detail
0.013 Venous Thrombosis NA GAD,LHGDN Detail
<0.001 Virus Diseases Sex-specific association of estrogen receptor 2 polymorphisms with hepatitis C v... BeFree 25261585 Detail
0.002 Vision Disorders NA GAD Detail
0.005 vitiligo NA BeFree,GAD Detail
<0.001 Fibromatosis, Aggressive NA BeFree Detail
<0.001 B-Cell Lymphomas B cell lymphoma/leukemia-2 (Bcl-2) expression has generally been associated with... BeFree 25179840 Detail
0.240 Malignant neoplasm of breast However, when this relation was assessed within strata based on estrogen-related... BeFree 22199302 Detail
0.005 Mammographic Density However, when this relation was assessed within strata based on estrogen-related... BeFree 22199302 Detail
0.080 breast carcinoma However, when this relation was assessed within strata based on estrogen-related... BeFree 22199302 Detail
0.003 Tooth Loss NA BeFree,GAD Detail
0.002 Peripheral Vascular Diseases NA GAD Detail
<0.001 severe combined immunodeficiency Importantly, tamoxifen also significantly inhibited invasive behavior in Matrige... BeFree 25892968 Detail
0.003 Bronchial Hyperreactivity NA BeFree,GAD Detail
<0.001 gestational diabetes NA BeFree Detail
0.010 Ovarian Failure, Premature NA BeFree,GAD,LHGDN Detail
0.005 Sudden cardiac death NA GAD Detail
<0.001 Li-Fraumeni syndrome NA BeFree Detail
<0.001 Neurofibrillary degeneration (morphologic abnormality) NA BeFree Detail
<0.001 Synovial Cyst NA BeFree Detail
0.002 Alcohol abuse NA GAD Detail
<0.001 Codependency NA BeFree Detail
0.001 Depressive Symptoms NA BeFree Detail
<0.001 cataract NA BeFree Detail
<0.001 Adnexal mass NA BeFree Detail
0.008 Left Ventricular Hypertrophy NA BeFree,GAD,LHGDN Detail
0.148 Migraine Disorders Impact of ESR1 Gene Polymorphisms on Migraine Susceptibility: A Meta-Analysis. BeFree,CTD_human,GAD,LHGDN 26334887 Detail
0.003 Lumbar spondylosis NA BeFree,GAD Detail
<0.001 Atrophic condition of skin NA BeFree Detail
0.002 Premature Birth NA GAD Detail
0.003 Myocardial Ischemia NA BeFree,GAD Detail
<0.001 Arterial thrombosis NA BeFree Detail
0.002 Adenocarcinoma of lung (disorder) NA BeFree Detail
<0.001 esophageal carcinoma NA BeFree Detail
<0.001 Idiopathic pulmonary hypertension ERα is highly expressed in female hPASMCs from PAH patients and mediates oestrog... BeFree 25765937 Detail
<0.001 Malignant neoplasm of gallbladder Global DNA Methylation Index (p = 0.02) and promoter methylation of SSBP2 (p = 0... BeFree 25066711 Detail
<0.001 Malignant neoplasm of testis NA BeFree Detail
0.001 Secondary malignant neoplasm of lung In line with these results and based on cDNA microarray data of breast cancer pa... BeFree 25666264 Detail
0.001 Secondary malignant neoplasm of lung Importantly, tamoxifen also significantly inhibited invasive behavior in Matrige... BeFree 25892968 Detail
0.002 Secondary malignant neoplasm of bone NA BeFree Detail
<0.001 Disorder of endocrine ovary NA BeFree Detail
0.003 migraine with aura NA BeFree,GAD Detail
<0.001 Hearing Loss, Mixed Conductive-Sensorineural NA BeFree Detail
0.002 acute myocardial infarction NA GAD Detail
0.001 endometriosis of ovary NA BeFree Detail
<0.001 Prolapse of female genital organs NA BeFree Detail
<0.001 Idiopathic osteoporosis NA BeFree Detail
0.003 Aortic Aneurysm, Abdominal NA BeFree,GAD Detail
<0.001 Agenesis of corpus callosum NA BeFree Detail
0.010 Tumor Progression MicroRNAs (miRNAs) are widely recognized as key players in cancer progression an... BeFree 25238878 Detail
0.010 Tumor Progression The findings suggest that selective inhibitors of transactivation by ER may be m... BeFree 25582774 Detail
0.010 Tumor Progression These findings demonstrate that Slug, by regulation of ERα expression, contribut... BeFree 25652255 Detail
0.010 Tumor Progression The development of breast cancer is linked to the loss of estrogen receptor (ER)... BeFree 25823469 Detail
<0.001 Adenocarcinoma, Tubular NA BeFree Detail
<0.001 Germ cell tumor NA BeFree Detail
<0.001 hepatoblastoma NA BeFree Detail
<0.001 endometrial stromal sarcoma NA BeFree Detail
0.003 Fibroadenoma NA BeFree,LHGDN Detail
<0.001 Rhabdomyosarcoma, Embryonal NA BeFree Detail
0.003 adrenal cortical adenoma NA LHGDN Detail
0.003 adrenocortical carcinoma NA BeFree,LHGDN Detail
0.008 Carcinoma, Endometrioid ECCCs had SCA-like features with rare expression of estrogen receptor/progestero... BeFree,GAD,LHGDN 25473756 Detail
0.002 Carcinoma, Lobular Infiltrating lobular carcinoma had a higher ER positivity between groups (85.7%)... BeFree 26266392 Detail
<0.001 Medullary carcinoma NA BeFree Detail
<0.001 cholangiocarcinoma NA BeFree Detail
<0.001 Cystadenocarcinoma, Mucinous NA BeFree Detail
0.001 Cystadenocarcinoma, Serous NA BeFree Detail
<0.001 gliosarcoma NA BeFree Detail
<0.001 Nerve Sheath Tumors NA BeFree Detail
<0.001 Angiofibroma Estrogen receptor α protein was detected in juvenile angiofibroma tumors and mes... BeFree 23996526 Detail
0.003 Neuroendocrine Tumors NA LHGDN Detail
<0.001 Hyperparathyroidism, Primary NA BeFree Detail
<0.001 Comedone NA BeFree Detail
<0.001 Lumbar disc disease NA BeFree Detail
<0.001 Obsessions NA BeFree Detail
<0.001 Malignant neoplasm of female breast AYA survival was worse for female breast cancer (regardless of estrogen receptor... BeFree 25417236 Detail
<0.001 gallbladder carcinoma Global DNA Methylation Index (p = 0.02) and promoter methylation of SSBP2 (p = 0... BeFree 25066711 Detail
<0.001 Cerebral atrophy After false discovery rate correction, we observed 53 significant associations b... BeFree 25570489 Detail
0.001 pancreatic carcinoma NA BeFree Detail
<0.001 Menopausal symptom NA BeFree Detail
0.002 Substance-Related Disorders NA GAD Detail
0.001 Carcinoma of male breast Male breast cancer is a hormone-driven disease that often expresses the estrogen... BeFree 26276719 Detail
<0.001 Medullary carcinoma of thyroid NA BeFree Detail
0.002 Papillary thyroid carcinoma Our investigation identified miR-219-5p as a negative regulator of PTC developme... BeFree 25423566 Detail
0.002 Papillary thyroid carcinoma Estrogen receptor α induces prosurvival autophagy in papillary thyroid cancer vi... BeFree 25594859 Detail
0.002 Papillary thyroid carcinoma We studied the expression of estrogen receptor α (ERα or ESR1) and progesterone ... BeFree 25862786 Detail
0.002 coronary stenosis NA GAD Detail
0.003 Dyslipidemias NA BeFree,GAD Detail
0.009 Malignant neoplasm of lung Knockdown of MEP50 retarded cell growth and migration in selected lung cancer ce... BeFree,GAD 25277535 Detail
0.003 age related macular degeneration NA BeFree,GAD Detail
0.080 Parkinsonian Disorders NA RGD Detail
<0.001 Residual Cancer NA BeFree Detail
<0.001 Neoplasm, Residual NA BeFree Detail
0.122 Disease Progression NA CTD_human,GAD Detail
0.001 Malignant neoplasm of male breast Male breast cancer is a hormone-driven disease that often expresses the estrogen... BeFree 26276719 Detail
0.003 Breast Neoplasms, Male NA BeFree,LHGDN Detail
0.002 Osteopenia/osteoporosis NA GAD Detail
<0.001 parathyroid adenoma NA BeFree Detail
<0.001 Degenerative spondylolisthesis NA BeFree Detail
0.003 Chronic Periodontitis NA BeFree,GAD Detail
<0.001 Cholestasis of pregnancy NA BeFree Detail
<0.001 Nephritic syndrome NA BeFree Detail
0.003 Vulvar Vestibulitis NA LHGDN Detail
0.002 Endometrioma NA BeFree Detail
<0.001 Severe myopia NA BeFree Detail
<0.001 Carcinoma breast stage I NA BeFree Detail
0.006 Carcinoma breast stage IV In estrogen receptor negative (ER-) metastatic breast cancer cells, equol induce... BeFree 25593313 Detail
0.006 Carcinoma breast stage IV A multiplex allele-specific real-time PCR assay for screening of ESR1 mutations ... BeFree 25746663 Detail
0.006 Carcinoma breast stage IV Noninvasive detection of activating estrogen receptor 1 (ESR1) mutations in estr... BeFree 25979954 Detail
0.006 Carcinoma breast stage IV Short report: Monitoring ESR1 mutations by circulating tumor DNA in aromatase in... BeFree 25994408 Detail
0.002 Breast cancer recurrent Tamoxifen has been used not only for the treatment or prevention of recurrence i... BeFree 25712191 Detail
0.002 inflammatory breast carcinoma Molecular aberrations affecting the PI3K pathway may play a role in the progress... BeFree 24634376 Detail
<0.001 gastric adenocarcinoma NA BeFree Detail
<0.001 Malignant Childhood Neoplasm NA BeFree Detail
<0.001 Non-small cell lung cancer metastatic NA BeFree Detail
<0.001 Liver and Intrahepatic Biliary Tract Carcinoma NA BeFree Detail
0.003 Malignant Bone Neoplasm NA BeFree,GAD Detail
<0.001 Invasive lobular breast carcinoma Pre- and on-treatment (after 2 weeks and 3 months) biopsies and surgical samples... BeFree 25100562 Detail
<0.001 Invasive lobular breast carcinoma Here, we evaluate telomere lengths within 48 primary ILCs with complete characte... BeFree 26092192 Detail
<0.001 Squamous cell carcinoma of esophagus NA BeFree Detail
<0.001 Adenocarcinoma Of Esophagus NA BeFree Detail
<0.001 Solid tumour NA BeFree Detail
<0.001 bilateral breast cancer NA BeFree Detail
0.200 Prostatic Intraepithelial Neoplasias NA CTD_human,RGD Detail
<0.001 Condyloma NA BeFree Detail
0.004 cervix carcinoma Activation of G-protein coupled estrogen receptor inhibits the proliferation of ... BeFree 25753185 Detail
0.004 cervix carcinoma Significantly, despite clinical, epidemiological, and animal model results linki... BeFree 26056290 Detail
<0.001 Restenosis NA BeFree Detail
<0.001 Superficial ulcer US abnormalities were independent of ePsA clinical indices (except erosions - ev... BeFree 25797649 Detail
<0.001 Tumor necrosis Independent adverse prognostic significance was retained in multivariable analys... BeFree 25970543 Detail
0.002 Atrophic NA GAD Detail
<0.001 Triploidy syndrome NA BeFree Detail
<0.001 anaplastic astrocytoma NA BeFree Detail
<0.001 Adenocarcinoma of colon NA BeFree Detail
0.005 Impaired cognition NA BeFree,GAD Detail
<0.001 Chronic liver disease NA BeFree Detail
<0.001 endometriosis of uterus NA BeFree Detail
<0.001 Precocious Puberty, Central NA BeFree Detail
<0.001 Malignant neoplasm of liver NA BeFree Detail
<0.001 malignant mesothelioma NA BeFree Detail
<0.001 Benign neoplasm of breast NA BeFree Detail
<0.001 immature teratoma of ovary NA BeFree Detail
<0.001 Malignant neoplasm of adrenal cortex NA BeFree Detail
0.001 Malignant neoplasm of pancreas NA BeFree Detail
<0.001 Disseminated Malignant Neoplasm NA BeFree Detail
<0.001 Depressive episode, unspecified NA BeFree Detail
<0.001 Phobic anxiety disorder NA BeFree Detail
<0.001 Squamous cell carcinoma of tongue NA BeFree Detail
<0.001 Obsessions Nevertheless, on analyzing OCD subphenotypes, SNP rs34535804 in ESR1 and a five ... BeFree 20850223 Detail
<0.001 Obsessive compulsive behavior Nevertheless, on analyzing OCD subphenotypes, SNP rs34535804 in ESR1 and a five ... BeFree 20850223 Detail
<0.001 Pulmonary lymphangioleiomyomatosis NA BeFree Detail
<0.001 Ischemic cardiomyopathy NA BeFree Detail
<0.001 premenstrual tension Effect of estrogen receptor gene ESR1 polymorphism on development of premenstrua... BeFree 25416214 Detail
0.061 Malignant neoplasm of prostate In context of functional enrichment analysis, interestingly candidate disease-as... BeFree,GAD 25080090 Detail
0.061 Malignant neoplasm of prostate Deciphering how this pathway is regulated and how FASTKD2 initiates the apoptoti... BeFree,GAD 25409762 Detail
0.061 Malignant neoplasm of prostate We used this strategy to screen several commercially-available chemical librarie... BeFree,GAD 25422593 Detail
0.061 Malignant neoplasm of prostate While high doses of estrogen, in combination with androgens, can initiate prosta... BeFree,GAD 25436982 Detail
0.061 Malignant neoplasm of prostate The present study shows that Slug has an inverse relationship with ERα in breast... BeFree,GAD 25652255 Detail
0.061 Malignant neoplasm of prostate Genistein has protective effects against prostate cancer (PCa) but whether this ... BeFree,GAD 25931004 Detail
0.061 Malignant neoplasm of prostate Here we report that a novel type of transfer RNA (tRNA)-derived small RNA, terme... BeFree,GAD 26124144 Detail
<0.001 Hematopoietic Neoplasms NA BeFree Detail
<0.001 Carcinoid tumor, malignant NA BeFree Detail
<0.001 thrombophilia Hypercoagulability in adolescent girls on oral contraceptives-global coagulation... BeFree 26014094 Detail
<0.001 Chronic Kidney Insufficiency NA BeFree Detail
<0.001 Undifferentiated inflammatory oligoarthritis NA BeFree Detail
<0.001 Idiopathic osteoarthritis NA BeFree Detail
0.008 Osteoarthritis, Knee NA BeFree,GAD Detail
0.002 lupus erythematosus NA BeFree Detail
0.003 Adolescent idiopathic scoliosis Association between the ESR1 -351A>G single nucleotide polymorphism (rs9340799) ... BeFree 25077943 Detail
0.002 Body Fat Distribution NA GAD Detail
0.002 Senile sclerosis of aortic cusp NA GAD Detail
0.002 Left ventricular mass NA GAD Detail
0.032 endometrial carcinoma The expression of HuR and estrogen receptor alpha (ER-α) protein was examined by... BeFree,GAD 25182852 Detail
0.032 endometrial carcinoma To characterize model cell lines of endometrial cancer, we determined the expres... BeFree,GAD 25437045 Detail
0.032 endometrial carcinoma Stimulation of peroxisome proliferator-activated receptor γ inhibits estrogen re... BeFree,GAD 25592200 Detail
0.032 endometrial carcinoma Our study revealed novel molecular mechanisms underlying the regulation of ERα p... BeFree,GAD 25766326 Detail
0.032 endometrial carcinoma HNRNP G and HTRA2-BETA1 regulate estrogen receptor alpha expression with potenti... BeFree,GAD 25884434 Detail
<0.001 Secondary malignant neoplasm of liver NA BeFree Detail
0.012 dementia NA BeFree,GAD Detail
0.003 Overweight Being highly obese, however, was inversely associated with ESR1 expression (adju... BeFree,GAD 25884832 Detail
0.002 body mass NA GAD Detail
<0.001 Chronic active hepatitis NA BeFree Detail
0.003 Premenstrual dysphoric disorder NA BeFree,GAD Detail
<0.001 Postpartum psychosis NA BeFree Detail
0.002 Recurrent tumor NA BeFree Detail
0.007 Metabolic syndrome X NA BeFree,GAD Detail
0.006 Hepatitis B, Chronic NA BeFree,GAD Detail
0.003 Mood Disorders NA BeFree,GAD Detail
0.001 Thyroid carcinoma NA BeFree Detail
<0.001 MALE GENITAL ABNORMALITIES NA BeFree Detail
0.002 Menopause present (finding) NA GAD Detail
<0.001 Lower Urinary Tract Symptoms NA BeFree Detail
0.005 Non-small cell lung carcinoma In this case-control study (830 non-small cell lung carcinoma (NSCLC) patients; ... BeFree 15331175 Detail
0.003 Osteosarcoma of bone In this study, OS cell MG-63 was treated with low (1 nM) or high (100 nM) dose o... BeFree 25592968 Detail
<0.001 Severe depression NA BeFree Detail
0.002 idiopathic scoliosis The estrogen receptor α gene (XbaI, PvuII) polymorphisms and susceptibility to i... BeFree 24961754 Detail
0.002 idiopathic scoliosis Estrogen receptor 2 gene polymorphism in idiopathic scoliosis. BeFree 25341980 Detail
0.026 Carcinogenesis However, our results suggest that promoter usage of ERα may contribute to its ex... BeFree 24332559 Detail
0.026 Carcinogenesis The BCL9-2 proto-oncogene governs estrogen receptor alpha expression in breast t... BeFree 25149534 Detail
0.026 Carcinogenesis RIP140, a regulator of estrogen receptor, recently has been found to be involved... BeFree 25391428 Detail
0.026 Carcinogenesis Ctr9, a key subunit of PAFc, affects global estrogen signaling and drives ERα-po... BeFree 26494790 Detail
<0.001 Obsessive compulsive behavior NA BeFree Detail
0.024 prostate carcinoma In context of functional enrichment analysis, interestingly candidate disease-as... BeFree,GAD 25080090 Detail
0.024 prostate carcinoma Deciphering how this pathway is regulated and how FASTKD2 initiates the apoptoti... BeFree,GAD 25409762 Detail
0.024 prostate carcinoma We used this strategy to screen several commercially-available chemical librarie... BeFree,GAD 25422593 Detail
0.024 prostate carcinoma While high doses of estrogen, in combination with androgens, can initiate prosta... BeFree,GAD 25436982 Detail
0.024 prostate carcinoma The present study shows that Slug has an inverse relationship with ERα in breast... BeFree,GAD 25652255 Detail
0.024 prostate carcinoma Genistein has protective effects against prostate cancer (PCa) but whether this ... BeFree,GAD 25931004 Detail
0.024 prostate carcinoma Here we report that a novel type of transfer RNA (tRNA)-derived small RNA, terme... BeFree,GAD 26124144 Detail
0.008 Hot flushes NA BeFree,GAD Detail
<0.001 toxic shock syndrome NA BeFree Detail
0.002 hepatopulmonary syndrome NA GAD Detail
<0.001 Gastro-esophageal reflux disease with esophagitis NA BeFree Detail
0.007 Epithelial ovarian cancer Interestingly, loss of PGC1α/TFAM and ERα was found also in a non-clear cell EOC... BeFree,GAD 25243473 Detail
0.007 Epithelial ovarian cancer The mRNA level for FOXP1 and ERβ in ovarian carcinoma tissues decreased, while t... BeFree,GAD 25500588 Detail
0.001 invasive cancer NA BeFree Detail
<0.001 Progressive Neoplastic Disease NA BeFree Detail
<0.001 Refractory cancer NA BeFree Detail
0.003 Carcinoma of lung Knockdown of MEP50 retarded cell growth and migration in selected lung cancer ce... BeFree 25277535 Detail
0.016 Secondary malignant neoplasm of lymph node The overall analysis showed that higher expression of ALDH1A1 is associated with... BeFree,GAD 24938375 Detail
0.016 Secondary malignant neoplasm of lymph node In addition, significant associations were also observed between TNFRSF1A polymo... BeFree,GAD 25010932 Detail
0.016 Secondary malignant neoplasm of lymph node The reduced RASA1 expression was significantly associated with tumor lymph node ... BeFree,GAD 25394563 Detail
0.016 Secondary malignant neoplasm of lymph node LOH in THRB was associated with negative estrogen receptor (ER), negative proges... BeFree,GAD 26350179 Detail
<0.001 Psychoticism NA BeFree Detail
0.002 Pregnancy loss NA GAD Detail
0.002 colon carcinoma In contrast, E2 could exert protective effects in cancer cells by activating apo... BeFree 25683270 Detail
0.002 stomach carcinoma NA BeFree Detail
<0.001 Carcinoma of bladder Estrogen receptor alpha prevents bladder cancer via INPP4B inhibited akt pathway... BeFree 25277204 Detail
<0.001 Malignant Female Reproductive System Neoplasm NA BeFree Detail
0.003 Central neuroblastoma NA BeFree Detail
<0.001 bile duct carcinoma NA BeFree Detail
<0.001 germ cell cancer NA BeFree Detail
<0.001 Postsurgical menopause NA BeFree Detail
<0.001 Substance abuse problem NA BeFree Detail
<0.001 early pregnancy NA BeFree Detail
<0.001 biliary tract cancer NA BeFree Detail
<0.001 lymphangioleiomyomatosis We conclude that together with LHS, ER may be considered a useful tool for evalu... BeFree 26026095 Detail
<0.001 malignant peripheral nerve sheath tumor NA BeFree Detail
<0.001 Marden-Walker syndrome NA BeFree Detail
0.014 hypospadias Genetic polymorphisms in ESR1 and ESR2 genes, and risk of hypospadias in a multi... BeFree,GAD,LHGDN 25463985 Detail
<0.001 Anaphylaxis (non medication) The enhanced severity of anaphylaxis in female mice was eliminated after pretrea... BeFree 25553642 Detail
0.002 Sleep Disorders NA GAD Detail
0.005 Pregnancy associated hypertension NA GAD,LHGDN Detail
<0.001 Arteriopathic disease NA BeFree Detail
0.001 Oestrogen deficiency NA BeFree Detail
0.009 Invasive breast carcinoma The differential regulation of miR-29b by S100A7 in ER-positive and ER-negative ... BeFree 25622979 Detail
0.009 Invasive breast carcinoma These biomarkers are routinely tested for in all invasive breast carcinomas; ER ... BeFree 25770732 Detail
0.009 Invasive breast carcinoma In this study, we analyzed TGFβ receptor type 2 (TGFBR2) expression and correlat... BeFree 25833830 Detail
0.009 Invasive breast carcinoma Selection criteria for study/center inclusion were estrogen receptor (ER) status... BeFree 25857409 Detail
0.009 Invasive breast carcinoma Adjuvant treatment for early stage, estrogen receptor (ER) positive invasive bre... BeFree 26095420 Detail
0.001 Testicular malignant germ cell tumor NA BeFree Detail
<0.001 Cholesterol gallstones NA BeFree Detail
0.002 breast adenocarcinoma With the purpose of evaluating their effect on breast cancer biology, o,p'-DDT, ... BeFree 23913582 Detail
<0.001 Medullary carcinoma of breast NA BeFree Detail
<0.001 lobular neoplasia NA BeFree Detail
<0.001 Pelvic Organ Prolapse NA BeFree Detail
<0.001 Advanced cancer NA BeFree Detail
0.002 arteriolosclerosis NA GAD Detail
<0.001 Stromal Neoplasm NA BeFree Detail
<0.001 Cerebral Aneurysm NA BeFree Detail
0.084 ovarian neoplasm NA BeFree,LHGDN,RGD Detail
0.002 Microsatellite Instability NA GAD Detail
<0.001 cancer recurrence NA BeFree Detail
<0.001 precancerous lesions NA BeFree Detail
0.003 cholecystolithiasis NA BeFree,GAD Detail
0.002 Ischemic stroke NA BeFree Detail
0.005 Acute coronary syndrome NA GAD Detail
0.002 coronary restenosis NA GAD Detail
<0.001 Papillomavirus Infections Molecular transitions from papillomavirus infection to cervical precancer and ca... BeFree 26056290 Detail
<0.001 Arthritis, Collagen-Induced NA BeFree Detail
<0.001 Contralateral breast cancer NA BeFree Detail
0.004 Invasive Ductal Breast Carcinoma Microarray-based gene expression and Affymetrix SNP 6.0 gene copy number profili... BeFree 25041824 Detail
0.004 Invasive Ductal Breast Carcinoma Pre- and on-treatment (after 2 weeks and 3 months) biopsies and surgical samples... BeFree 25100562 Detail
0.004 Invasive Ductal Breast Carcinoma We analyzed the changes in mitochondrial DNA (mtDNA) copy numbers and the shifti... BeFree 25845386 Detail
0.022 Malignant neoplasm of ovary Inhibitory effects of aromatase inhibitor on estrogen receptor-alpha positive ov... BeFree,GAD 24410765 Detail
0.022 Malignant neoplasm of ovary Importantly, this BTB mediated inhibition of ER activity is selective since BTB ... BeFree,GAD 25221777 Detail
0.022 Malignant neoplasm of ovary BRCA mutations were detected in 26 of 92 patients (28%) with ovarian cancer, in ... BeFree,GAD 25236687 Detail
0.022 Malignant neoplasm of ovary E2-ERα activates all three arms of the UPR in breast and ovarian cancer cells in... BeFree,GAD 25263449 Detail
0.022 Malignant neoplasm of ovary Using screening and functional validation, we identified BHPI, a potent noncompe... BeFree,GAD 25825714 Detail
0.022 Malignant neoplasm of ovary Effect of fenhexamid and cyprodinil on the expression of cell cycle- and metasta... BeFree,GAD 26344002 Detail
0.002 endometrial adenocarcinoma NA BeFree Detail
<0.001 Squamous cell carcinoma of the head and neck Aberrant promoter methylation of IGSF4, DAPK1, and ESR1 genes, known to be methy... BeFree 25569158 Detail
0.004 Ductal Carcinoma NA BeFree Detail
0.001 Mammary Carcinoma, Human NA BeFree Detail
<0.001 Myxoid cyst NA BeFree Detail
<0.001 sarcoma NA BeFree Detail
<0.001 Lymphocytic infiltration NA BeFree Detail
<0.001 Atypical carcinoid tumor NA BeFree Detail
<0.001 Thyroid Gland Spindle Cell Tumor with Thymus-Like Differentiation NA BeFree Detail
<0.001 Benign cystic nephroma NA BeFree Detail
<0.001 Nonseminomatous germ cell tumor NA BeFree Detail
0.006 major depressive disorder NA BeFree,GAD,LHGDN Detail
<0.001 Mild cognitive disorder NA BeFree Detail
0.002 Systemic arterial pressure NA GAD Detail
<0.001 Lipoatrophy NA BeFree Detail
<0.001 Enthesitis NA BeFree Detail
<0.001 Degenerative disorder Estrogen receptor-alpha polymorphism in patients with and without degenerative d... BeFree 25178548 Detail
<0.001 Inflammatory disorder NA BeFree Detail
<0.001 Single tumor NA BeFree Detail
<0.001 Salivary duct carcinoma NA BeFree Detail
<0.001 Adenoma of large intestine NA BeFree Detail
0.002 Age at menarche NA GAD Detail
<0.001 Hormone refractory prostate cancer NA BeFree Detail
<0.001 Adenoid cystic breast carcinoma NA BeFree Detail
<0.001 Breast Fibrocystic Change, Proliferative Type NA BeFree Detail
<0.001 Hereditary Paraganglioma NA BeFree Detail
<0.001 Invasive Carcinoma NA BeFree Detail
<0.001 Malignant Mixed Mesodermal (Mullerian) Tumor NA BeFree Detail
<0.001 Ovarian Transitional Cell Carcinoma NA BeFree Detail
<0.001 Refractory Neoplasm NA BeFree Detail
0.005 Sporadic Breast Carcinoma DNA methyltransferase 1/3a overexpression in sporadic breast cancer is associate... BeFree 24464625 Detail
0.003 Testicular Germ Cell Tumor NA BeFree,GAD Detail
<0.001 Endometrial Endometrioid Adenocarcinoma NA BeFree Detail
<0.001 Epithelioma NA BeFree Detail
<0.001 Papillary urothelial carcinoma NA BeFree Detail
<0.001 Granulosa cell tumor of the ovary The G-protein-coupled estrogen receptor (GPER/GPR30) in ovarian granulosa cell t... BeFree 25167139 Detail
<0.001 Generalized osteoarthritis NA BeFree Detail
<0.001 Cognitive changes Thus, a deeper analysis of ERs could elucidate the role of estrogen in age-relat... BeFree 25159676 Detail
<0.001 Cardiomyopathy, Familial Idiopathic Pre- and on-treatment (after 2 weeks and 3 months) biopsies and surgical samples... BeFree 25100562 Detail
0.002 Aortic valve sclerosis NA GAD Detail
<0.001 sclerosing hemangioma NA BeFree Detail
<0.001 Breast Cancer Model Herein, we probed estrogen receptor-α (ER) and progesterone receptor (PR) cross-... BeFree 24469035 Detail
<0.001 Hepatocarcinogenesis NA BeFree Detail
0.002 Mammary Tumorigenesis NA BeFree Detail
<0.001 Cancer Cell Growth NA BeFree Detail
<0.001 ovarian clear cell adenocarcinoma NA BeFree Detail
<0.001 Tumor Promotion NA BeFree Detail
0.002 Xenograft Model NA BeFree Detail
0.012 colorectal cancer Independent adverse prognostic significance was retained in multivariable analys... BeFree,GAD 25970543 Detail
<0.001 Sjogren's syndrome NA BeFree Detail
<0.001 Ductal Breast Carcinoma NA BeFree Detail
<0.001 Neoplasms, Intracranial NA BeFree Detail
<0.001 Chronic Kidney Diseases NA BeFree Detail
<0.001 Progesterone receptor positive tumor The aim of this study was to evaluate the association of CYP2D6*10 (c.100C>T and... BeFree 25701109 Detail
0.002 Adenocarcinoma, Endometrioid ECCCs had SCA-like features with rare expression of estrogen receptor/progestero... BeFree 25473756 Detail
<0.001 Cirrhosis NA BeFree Detail
<0.001 androgen independent prostate cancer Deciphering how this pathway is regulated and how FASTKD2 initiates the apoptoti... BeFree 25409762 Detail
<0.001 androgen independent prostate cancer Accordingly, it decreased expression of ER-α target PS2 (P<0.01) and increased e... BeFree 25655200 Detail
0.002 Penile hypospadias Genetic polymorphisms in ESR1 and ESR2 genes, and risk of hypospadias in a multi... BeFree 25463985 Detail
0.002 Benign Prostatic Hyperplasia NA BeFree Detail
<0.001 Osteoblastic osteosarcoma NA BeFree Detail
<0.001 Neonatal Deformity Estrogenic endocrine disruptors acting via estrogen receptors α (ESR1) and β (ES... BeFree 25463985 Detail
<0.001 Apocrine Gland Carcinoma NA BeFree Detail
0.001 Non-Neoplastic Disorder NA BeFree Detail
<0.001 Endometrial Diseases NA BeFree Detail
0.120 Sudden Cardiac Arrest NA GWASCAT Detail
0.120 Female Urogenital Diseases NA CTD_human Detail
0.002 Meningioma, benign, no ICD-O subtype NA BeFree Detail
<0.001 MULTICYSTIC RENAL DYSPLASIA, BILATERAL NA BeFree Detail
0.002 NEUROTICISM NA GAD Detail
<0.001 VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding) NA BeFree Detail
<0.001 Progesterone Resistance NA BeFree Detail
0.120 HDL CHOLESTEROL, AUGMENTED RESPONSE OF, TO HORMONE REPLACEMENT NA CLINVAR Detail
0.120 Atherosclerosis, susceptibility to NA CLINVAR Detail
<0.001 lateral meningocele syndrome NA BeFree Detail
<0.001 ECTRODACTYLY, ECTODERMAL DYSPLASIA, AND CLEFT LIP/PALATE SYNDROME 1 NA BeFree Detail
<0.001 BREAST CANCER 3 NA BeFree Detail
0.007 Venous thromboembolism NA GAD,LHGDN Detail
<0.001 Syndactyly, Type IV NA BeFree Detail
<0.001 Pulmonary arterial hypertension associated with portal hypertension NA BeFree Detail
0.017 uterine corpus cancer To characterize model cell lines of endometrial cancer, we determined the expres... BeFree 25437045 Detail
0.017 uterine corpus cancer Our study revealed novel molecular mechanisms underlying the regulation of ERα p... BeFree 25766326 Detail
0.017 uterine corpus cancer HNRNP G and HTRA2-BETA1 regulate estrogen receptor alpha expression with potenti... BeFree 25884434 Detail
0.165 coronary artery disease NA BeFree,CTD_human,GAD,LHGDN Detail
0.003 Precursor Cell Lymphoblastic Leukemia Lymphoma AYA survival was worse for female breast cancer (regardless of estrogen receptor... BeFree,GAD 25417236 Detail
<0.001 aromatase excess syndrome NA BeFree Detail
<0.001 Alzheimer Disease 12 NA BeFree Detail
<0.001 malignant neoplasm of breast stage I NA BeFree Detail
<0.001 malignant neoplasm of breast staging NA BeFree Detail
0.138 liver carcinoma Inhibition of hepatocellular carcinoma by fulvestrant involves the estrogen rece... BeFree,CTD_human,GAD,LHGDN 25270093 Detail
0.138 liver carcinoma Western blot analysis indicated that estrogen receptor-α (ERα) was downregulated... BeFree,CTD_human,GAD,LHGDN 25483016 Detail
<0.001 bulimia nervosa NA BeFree Detail
<0.001 Chronic kidney disease stage 5 NA BeFree Detail
<0.001 XERODERMA PIGMENTOSUM, COMPLEMENTATION GROUP C NA BeFree Detail
0.002 Infection of amniotic sac and membranes, unspecified, unspecified trimester, not applicable or unspecified NA GAD Detail
<0.001 Nasopharyngeal carcinoma NA BeFree Detail
0.005 Cerebral Hemorrhage NA GAD,LHGDN Detail
0.080 Prostatic Hyperplasia NA BeFree,RGD Detail
<0.001 Pulmonary arterial hypertension ERα is highly expressed in female hPASMCs from PAH patients and mediates oestrog... BeFree 25765937 Detail
0.001 Early-Stage Breast Carcinoma NA BeFree Detail
0.002 Ischemic Cerebrovascular Accident NA BeFree Detail
<0.001 Mild dementia NA BeFree Detail
0.003 Juvenile arthritis NA BeFree,GAD Detail
<0.001 Progressive cGVHD NA BeFree Detail
0.024 Triple Negative Breast Neoplasms Triple-negative breast cancers (TNBC) are defined as not having amplification of... BeFree 23456737 Detail
0.024 Triple Negative Breast Neoplasms Triple-negative breast cancer (TNBC) is a distinct breast cancer subtype defined... BeFree 24786829 Detail
0.024 Triple Negative Breast Neoplasms Triple-negative breast cancer (TNBC) is a clinically aggressive subtype of breas... BeFree 24866769 Detail
0.024 Triple Negative Breast Neoplasms Triple negative breast cancer (TNBC) and often basal-like cancers are defined as... BeFree 25100201 Detail
0.024 Triple Negative Breast Neoplasms Triple-negative breast cancer (TNBC) is defined by reduced expression of the est... BeFree 25212833 Detail
0.024 Triple Negative Breast Neoplasms Triple-negative breast cancer (TNBC) is a subgroup of breast cancers that by def... BeFree 25310144 Detail
0.024 Triple Negative Breast Neoplasms Triple-negative breast cancers (TNBC), negative for estrogen receptor, progester... BeFree 25344583 Detail
0.024 Triple Negative Breast Neoplasms Previous studies report an association between activation of the UPR and reduced... BeFree 25347741 Detail
0.024 Triple Negative Breast Neoplasms The reduced RASA1 expression was significantly associated with tumor lymph node ... BeFree 25394563 Detail
0.024 Triple Negative Breast Neoplasms Particularly breast cancers, which do not express estrogen receptor α (ERα) and ... BeFree 25420519 Detail
0.024 Triple Negative Breast Neoplasms Triple negative breast cancers (TNBCs) are defined by the lack of estrogen recep... BeFree 25453096 Detail
0.024 Triple Negative Breast Neoplasms Due to the lack of ERα, triple negative breast cancers (TNBCs) are not susceptib... BeFree 25496649 Detail
0.024 Triple Negative Breast Neoplasms HDAC inhibition does not induce estrogen receptor in human triple-negative breas... BeFree 25503779 Detail
0.024 Triple Negative Breast Neoplasms Well-known risk factors for ER-positive cancers, such as reproductive history an... BeFree 25527230 Detail
0.024 Triple Negative Breast Neoplasms Despite these advances, vexing clinical challenges remain particularly related t... BeFree 25566982 Detail
0.024 Triple Negative Breast Neoplasms Triple-negative breast cancer (TNBC) is defined by the absence of expression of ... BeFree 25571912 Detail
0.024 Triple Negative Breast Neoplasms Our results show that PSMC3IP and EPSTI1 are able to modulate the extrinsic apop... BeFree 25590583 Detail
0.024 Triple Negative Breast Neoplasms Triple negative breast cancer (TNBC) represents approximately 15% of breast canc... BeFree 25611337 Detail
0.024 Triple Negative Breast Neoplasms Of the 122 patients with subtypes available, 41 patients (31%) were classified a... BeFree 25638395 Detail
0.024 Triple Negative Breast Neoplasms Positive immunostaining for USP2 was detected in breast tumors and was correlate... BeFree 25687182 Detail
0.024 Triple Negative Breast Neoplasms Triple negative breast cancer (TNBC) is a distinct breast cancer subtype, which ... BeFree 25748387 Detail
0.024 Triple Negative Breast Neoplasms Characterization of macrophage--cancer cell crosstalk in estrogen receptor posit... BeFree 25776849 Detail
0.024 Triple Negative Breast Neoplasms Furthermore, whereas MEL-18 loss in luminal breast cancer cells resulted in the ... BeFree 25822021 Detail
0.024 Triple Negative Breast Neoplasms High-throughput technologies allow deepening into the molecular architecture of ... BeFree 25883093 Detail
0.024 Triple Negative Breast Neoplasms We applied DERA to identify key regulations in triple negative breast cancer (TN... BeFree 25928379 Detail
0.024 Triple Negative Breast Neoplasms We examined the effect of a synthetic REV-ERB agonist, SR9011, on a range of est... BeFree 26074263 Detail
0.024 Triple Negative Breast Neoplasms Since TNBC lacks expression of ERα, PR and HER2, existing targeted treatments ar... BeFree 26088362 Detail
0.024 Triple Negative Breast Neoplasms As a result of the 2010 American Society of Clinical Oncology (ASCO)/College of ... BeFree 26280679 Detail
<0.001 aortic valve disease 2 NA BeFree Detail
<0.001 Basal-Like Breast Carcinoma NA BeFree Detail
<0.001 Mammary adenocarcinoma NA BeFree Detail
0.003 Infection NA LHGDN Detail
<0.001 RETINOSCHISIS 1, X-LINKED, JUVENILE NA BeFree Detail
<0.001 juvenile rheumatoid arthritis NA BeFree Detail
<0.001 Pulmonary hypertension, primary, 1, with hereditary hemorrhagic telangiectasia ERα is highly expressed in female hPASMCs from PAH patients and mediates oestrog... BeFree 25765937 Detail
0.243 ESTROGEN RESISTANCE NA BeFree,ORPHANET,UNIPROT Detail
<0.001 Experimental Organism Basal Cell Carcinoma NA BeFree Detail
<0.001 Vulvar Intraepithelial Neoplasia, Usual Type NA BeFree Detail
<0.001 High grade serous carcinoma NA BeFree Detail
<0.001 Diminished ovarian reserve Twenty-one articles identified genes associated with DOR: one gene mutation (FMR... BeFree 24840722 Detail
<0.001 Congenital Abnormality Estrogenic endocrine disruptors acting via estrogen receptors α (ESR1) and β (ES... BeFree 25463985 Detail
0.002 Spontaneous abortion NA GAD Detail
0.240 Malignant neoplasm of breast In the validation study using Stage I of the 2,273 cases and 2,052 controls, sev... BeFree 22452962 Detail
0.080 breast carcinoma In the validation study using Stage I of the 2,273 cases and 2,052 controls, sev... BeFree 22452962 Detail
0.005 Abortion, Habitual NA GAD Detail
0.134 adenocarcinoma Some studies have shown that activation of estrogen and estrogen receptor α or β... BeFree,CTD_human,LHGDN 25692143 Detail
0.005 adenoma NA BeFree,LHGDN Detail
0.002 Alcoholic Intoxication, Chronic NA GAD Detail
0.003 Alveolar Bone Loss NA BeFree,GAD Detail
<0.001 Anaplasia NA BeFree Detail
<0.001 cutaneous fibrous histiocytoma NA BeFree Detail
0.003 anorexia nervosa NA BeFree,GAD Detail
0.005 Anoxia NA LHGDN Detail
0.001 Anxiety Disorders NA BeFree Detail
<0.001 aortic valve insufficiency Aromatase inhibitors (AIs) are the standard endocrine therapy for postmenopausal... BeFree 24413080 Detail
<0.001 aortic valve insufficiency Aromatase inhibitor (AI) treatment is first-line systemic treatment for the majo... BeFree 25625755 Detail
<0.001 aortic valve stenosis NA BeFree Detail
0.005 arteriosclerosis G protein-coupled estrogen receptor protects from atherosclerosis. BeFree,GAD 25532911 Detail
<0.001 arthritis NA BeFree Detail
0.006 rheumatoid arthritis NA BeFree,GAD Detail
0.005 asthma NA BeFree,GAD Detail
0.121 Astrocytoma NA BeFree,CTD_human Detail
0.134 atherosclerosis G protein-coupled estrogen receptor protects from atherosclerosis. BeFree,CTD_human,GAD,LHGDN 25532911 Detail
0.002 atrial fibrillation NA GAD Detail
0.002 autistic disorder NA GAD Detail
<0.001 Autoimmune Diseases NA BeFree Detail
0.005 azoospermia NA BeFree,GAD Detail
<0.001 Melanoma, B16 NA BeFree Detail
<0.001 Mental disorders NA BeFree Detail
0.002 beta thalassemia NA GAD Detail
0.002 Biliary Tract Neoplasm NA GAD Detail
0.009 bipolar disorder NA BeFree,GAD,LHGDN Detail
0.003 Malignant neoplasm of urinary bladder Estrogen receptor alpha prevents bladder cancer via INPP4B inhibited akt pathway... BeFree,GAD 25277204 Detail
<0.001 bladder neck obstruction NA BeFree Detail
0.120 Bladder Neoplasm NA CTD_human Detail
0.003 Bone Diseases NA BeFree,GAD Detail
0.002 Bone Diseases, Developmental NA GAD Detail
0.120 Metabolic Bone Disorder NA CTD_human Detail
<0.001 Brain Neoplasms NA BeFree Detail
0.003 Breast Diseases NA BeFree,LHGDN Detail
0.002 Cadmium poisoning NA GAD Detail
0.005 Malignant tumor of colon In contrast, E2 could exert protective effects in cancer cells by activating apo... BeFree,GAD 25683270 Detail
0.017 Malignant neoplasm of endometrium To characterize model cell lines of endometrial cancer, we determined the expres... BeFree 25437045 Detail
0.017 Malignant neoplasm of endometrium Our study revealed novel molecular mechanisms underlying the regulation of ERα p... BeFree 25766326 Detail
0.017 Malignant neoplasm of endometrium HNRNP G and HTRA2-BETA1 regulate estrogen receptor alpha expression with potenti... BeFree 25884434 Detail
<0.001 female breast carcinoma AYA survival was worse for female breast cancer (regardless of estrogen receptor... BeFree 25417236 Detail
<0.001 Adenocarcinoma of prostate NA BeFree Detail
0.002 Rectal Carcinoma NA GAD Detail
<0.001 Malignant neoplasm of thyroid NA BeFree Detail
0.006 Noninfiltrating Intraductal Carcinoma Molecular aberrations affecting the PI3K pathway may play a role in the progress... BeFree 24634376 Detail
0.006 Noninfiltrating Intraductal Carcinoma These biomarkers are routinely tested for in all invasive breast carcinomas; ER ... BeFree 25770732 Detail
<0.001 mucinous adenocarcinoma NA BeFree Detail
0.005 Non-small cell lung carcinoma Melatonin exhibits oncostatic activity in several cancers but does not lead to c... BeFree 25085583 Detail
0.005 Non-small cell lung carcinoma Estrogen receptor 1 gene expression and its combination with estrogen receptor 2... BeFree 25310221 Detail
0.005 Non-small cell lung carcinoma SNAI2/SLUG and estrogen receptor mRNA expression are inversely correlated and pr... BeFree 25928859 Detail
<0.001 Carcinoma, Papillary Microarray-based gene expression and Affymetrix SNP 6.0 gene copy number profili... BeFree 25041824 Detail
0.010 renal cell carcinoma Expression analysis of the estrogen receptor target genes in renal cell carcinom... BeFree,GAD,LHGDN 25351113 Detail
0.010 renal cell carcinoma The levels of Smad4 and forkhead box protein H1 (FOXH1) mRNA were reduced, while... BeFree,GAD,LHGDN 25482028 Detail
Annotation

Annotations

DescrptionSourceLinks
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Activation of G-protein coupled estrogen receptor inhibits the proliferation of cervical cancer cell... DisGeNET Detail
Significantly, despite clinical, epidemiological, and animal model results linking estrogen and estr... DisGeNET Detail
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Molecular transitions from papillomavirus infection to cervical precancer and cancer: Role of stroma... DisGeNET Detail
Global DNA Methylation Index (p = 0.02) and promoter methylation of SSBP2 (p = 0.01) and ESR1 (p = 0... DisGeNET Detail
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Taken together, our data indicate that EE2-induced cholestasis increases SHP and represses CYP2D6 ex... DisGeNET Detail
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Independent adverse prognostic significance was retained in multivariable analysis for absence of ne... DisGeNET Detail
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Several SNPs in MAP3K9 were associated with ER+/PR+ tumors and interacted with dietary oxidative bal... DisGeNET Detail
Analyses stratified by estrogen receptor status (ER) showed that the diabetes GRS was inversely asso... DisGeNET Detail
Several SNPs in MAP3K9 were associated with ER+/PR+ tumors and interacted with dietary oxidative bal... DisGeNET Detail
Analyses stratified by estrogen receptor status (ER) showed that the diabetes GRS was inversely asso... DisGeNET Detail
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New target genes in endometrial tumors show a role for the estrogen-receptor pathway in microsatelli... DisGeNET Detail
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However, the absence of clinical history of hormone exposure, predominance of smooth muscle with lac... DisGeNET Detail
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We present data that letrozole, an extensively used aromatase inhibitor in the treatment of estrogen... DisGeNET Detail
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ECCCs had SCA-like features with rare expression of estrogen receptor/progesterone receptor (18.8%/6... DisGeNET Detail
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Sex-specific association of estrogen receptor 2 polymorphisms with hepatitis C virus infection outco... DisGeNET Detail
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ERβ, VDR and 1OHase expression and activity were inhibited by hyperglycemia, but ERα expression was ... DisGeNET Detail
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It is concluded that as oestrogen is concerned in male gamete maturation, ER-α gene polymorphisms mi... DisGeNET Detail
Association of polymorphisms in estrogen receptors (ESR1 and ESR2) with male infertility: a meta-ana... DisGeNET Detail
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Our results suggest that the common Leu84Phe and Ile143Val polymorphisms in MGMT influence risk of c... DisGeNET Detail
Our results suggest that the common Leu84Phe and Ile143Val polymorphisms in MGMT influence risk of c... DisGeNET Detail
The primary endpoint, 4-variable, 28-joint disease activity score erythrocyte sedimentation rate (DA... DisGeNET Detail
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Our results suggested that both CYP17A1 and ESR1 polymorphisms may modulate the effects of phthalate... DisGeNET Detail
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β2-M silencing significantly inhibited Bcl-2 mRNA expression, but did not inhibit ER, PR and HER-2 m... DisGeNET Detail
Mixed lineage leukaemia histone methylases 1 collaborate with ERα to regulate HOXA10 expression in A... DisGeNET Detail
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AYA survival was worse for female breast cancer (regardless of estrogen receptor status), acute lymp... DisGeNET Detail
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Mixed lineage leukaemia histone methylases 1 collaborate with ERα to regulate HOXA10 expression in A... DisGeNET Detail
AYA survival was worse for female breast cancer (regardless of estrogen receptor status), acute lymp... DisGeNET Detail
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Meta-analysis of associations of IL1 receptor antagonist and estrogen receptor gene polymorphisms wi... DisGeNET Detail
Association of estrogen receptor 1 (ESR1) haplotypes with risk for systemic lupus erythematosus amon... DisGeNET Detail
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The role of ESR2 [estrogen receptor (ER)-β] in promoting Med growth was comprehensively examined in ... DisGeNET Detail
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MTDH overexpression was significantly associated with a high nuclear grade, negative estrogen recept... DisGeNET Detail
IL-13Rα2 mediates PNR-induced migration and metastasis in ERα-negative breast cancer. DisGeNET Detail
Triple-negative breast cancer (TNBC) is a distinct breast cancer subtype defined by the absence of e... DisGeNET Detail
Conversely, the IFN metagene was associated with a low risk of metastasis in 104 ERBB2+ tumors (P = ... DisGeNET Detail
Significant association was observed between diversin overexpression and TNM stage (p = 0.0036), nod... DisGeNET Detail
Furthermore, we find that elevated PHLDA1 expression is associated with a higher risk of distant met... DisGeNET Detail
A small, distinct subgroup of the ER negative patients was identified which exhibited a considerably... DisGeNET Detail
In breast cancer, PR becomes highly correlated with ER, and this convergence is associated with sign... DisGeNET Detail
Recurrence or early metastasis remains the predominant cause of mortality in patients with estrogen ... DisGeNET Detail
Tpx2, the most highly connected gene within a proliferation network specifically prognostic for estr... DisGeNET Detail
Association of miR-1266 with recurrence/metastasis potential in estrogen receptor positive breast ca... DisGeNET Detail
Benzophenone-1 and nonylphenol stimulated MCF-7 breast cancer growth by regulating cell cycle and me... DisGeNET Detail
These results indicate that tamoxifen can significantly accelerate Twist1 degradation to suppress ca... DisGeNET Detail
Early identification of ESR1 mutations by liquid biopsy might allow for cessation of ineffective end... DisGeNET Detail
For these patients, Sanger sequencing identified four metastases with clear ESR1 mutation and one po... DisGeNET Detail
MicroRNAs associated with the development of distant metastasis were identified in a cohort of 92 ES... DisGeNET Detail
Autocrine human growth hormone stimulates the tumor initiating capacity and metastasis of estrogen r... DisGeNET Detail
In 224 adjuvant hormonal treatment-naïve estrogen receptor (ER, ESR1)-positive patients who received... DisGeNET Detail
Effect of fenhexamid and cyprodinil on the expression of cell cycle- and metastasis-related genes vi... DisGeNET Detail
Higher gelsolin expression correlated with lower tumor stage and grade, and slower cell proliferatio... DisGeNET Detail
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Both Esr1 and CYP19A1 overexpressing mice responded to letrozole with reduced hyperplastic alveolar ... DisGeNET Detail
Estrogen receptor (ER)α-regulated lipocalin 2 expression in adipose tissue links obesity with breast... DisGeNET Detail
Obesity is associated with a worse breast cancer prognosis, particularly in estrogen receptor alpha ... DisGeNET Detail
Obesity is associated with altered methylation overall, and with hypermethylation among ER-positive ... DisGeNET Detail
These results suggest that adipocytes can modify breast cancer cell ER gene expression through hypox... DisGeNET Detail
Being highly obese, however, was inversely associated with ESR1 expression (adjusted mean difference... DisGeNET Detail
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These genes all displayed estradiol (E2)-dependent induction in human fetal osteoblasts transfected ... DisGeNET Detail
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In this study, OS cell MG-63 was treated with low (1 nM) or high (100 nM) dose of 17β-Estradiol (E2)... DisGeNET Detail
Inhibitory effects of aromatase inhibitor on estrogen receptor-alpha positive ovarian cancer in mice... DisGeNET Detail
Importantly, this BTB mediated inhibition of ER activity is selective since BTB does not suppress th... DisGeNET Detail
BRCA mutations were detected in 26 of 92 patients (28%) with ovarian cancer, in 14 of 96 patients (1... DisGeNET Detail
E2-ERα activates all three arms of the UPR in breast and ovarian cancer cells in culture and in a mo... DisGeNET Detail
The mRNA level for FOXP1 and ERβ in ovarian carcinoma tissues decreased, while the expression level ... DisGeNET Detail
Using screening and functional validation, we identified BHPI, a potent noncompetitive small molecul... DisGeNET Detail
Effect of fenhexamid and cyprodinil on the expression of cell cycle- and metastasis-related genes vi... DisGeNET Detail
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Thus, we sought to determine the effects of polymorphisms in COMT and functionally related pain gene... DisGeNET Detail
Early stage of BC demonstrated higher HPV positivity, and BC positive for estrogen receptor (ER) sho... DisGeNET Detail
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Estrogen receptor αlpha gene (ESR1) PvuII and XbaI polymorphisms are associated to metabolic and pro... DisGeNET Detail
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Effect of estrogen receptor gene ESR1 polymorphism on development of premenstrual syndrome. DisGeNET Detail
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US abnormalities were independent of ePsA clinical indices (except erosions - even if represented on... DisGeNET Detail
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Reverse transcription-polymerase chain reaction (RT-PCR), flow cytometry, and enzyme-linked immuno s... DisGeNET Detail
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An unexpected finding concerns the relatively high numbers of ER-positive and non-TN tumors within C... DisGeNET Detail
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Our results suggested that both CYP17A1 and ESR1 polymorphisms may modulate the effects of phthalate... DisGeNET Detail
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Sex-specific association of estrogen receptor 2 polymorphisms with hepatitis C virus infection outco... DisGeNET Detail
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B cell lymphoma/leukemia-2 (Bcl-2) expression has generally been associated with estrogen receptor p... DisGeNET Detail
However, when this relation was assessed within strata based on estrogen-related factors, a few SNPs... DisGeNET Detail
However, when this relation was assessed within strata based on estrogen-related factors, a few SNPs... DisGeNET Detail
However, when this relation was assessed within strata based on estrogen-related factors, a few SNPs... DisGeNET Detail
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Importantly, tamoxifen also significantly inhibited invasive behavior in Matrigel and lung metastasi... DisGeNET Detail
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Impact of ESR1 Gene Polymorphisms on Migraine Susceptibility: A Meta-Analysis. DisGeNET Detail
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ERα is highly expressed in female hPASMCs from PAH patients and mediates oestrogen-induced prolifera... DisGeNET Detail
Global DNA Methylation Index (p = 0.02) and promoter methylation of SSBP2 (p = 0.01) and ESR1 (p = 0... DisGeNET Detail
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In line with these results and based on cDNA microarray data of breast cancer patients (n = 197), hi... DisGeNET Detail
Importantly, tamoxifen also significantly inhibited invasive behavior in Matrigel and lung metastasi... DisGeNET Detail
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MicroRNAs (miRNAs) are widely recognized as key players in cancer progression and drug resistance, b... DisGeNET Detail
The findings suggest that selective inhibitors of transactivation by ER may be more beneficial in re... DisGeNET Detail
These findings demonstrate that Slug, by regulation of ERα expression, contributes to tumor progress... DisGeNET Detail
The development of breast cancer is linked to the loss of estrogen receptor (ER) during the course o... DisGeNET Detail
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ECCCs had SCA-like features with rare expression of estrogen receptor/progesterone receptor (18.8%/6... DisGeNET Detail
Infiltrating lobular carcinoma had a higher ER positivity between groups (85.7%), whereas noninvasiv... DisGeNET Detail
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Estrogen receptor α protein was detected in juvenile angiofibroma tumors and mesenchymal cell lines. DisGeNET Detail
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AYA survival was worse for female breast cancer (regardless of estrogen receptor status), acute lymp... DisGeNET Detail
Global DNA Methylation Index (p = 0.02) and promoter methylation of SSBP2 (p = 0.01) and ESR1 (p = 0... DisGeNET Detail
After false discovery rate correction, we observed 53 significant associations between SNPs and our ... DisGeNET Detail
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Male breast cancer is a hormone-driven disease that often expresses the estrogen receptor, and antie... DisGeNET Detail
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Our investigation identified miR-219-5p as a negative regulator of PTC development through targeting... DisGeNET Detail
Estrogen receptor α induces prosurvival autophagy in papillary thyroid cancer via stimulating reacti... DisGeNET Detail
We studied the expression of estrogen receptor α (ERα or ESR1) and progesterone receptor (PR or PGR)... DisGeNET Detail
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Knockdown of MEP50 retarded cell growth and migration in selected lung cancer cell lines, which expr... DisGeNET Detail
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Male breast cancer is a hormone-driven disease that often expresses the estrogen receptor, and antie... DisGeNET Detail
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In estrogen receptor negative (ER-) metastatic breast cancer cells, equol induced elevated levels of... DisGeNET Detail
A multiplex allele-specific real-time PCR assay for screening of ESR1 mutations in metastatic breast... DisGeNET Detail
Noninvasive detection of activating estrogen receptor 1 (ESR1) mutations in estrogen receptor-positi... DisGeNET Detail
Short report: Monitoring ESR1 mutations by circulating tumor DNA in aromatase inhibitor resistant me... DisGeNET Detail
Tamoxifen has been used not only for the treatment or prevention of recurrence in patients with estr... DisGeNET Detail
Molecular aberrations affecting the PI3K pathway may play a role in the progression from high-grade ... DisGeNET Detail
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Pre- and on-treatment (after 2 weeks and 3 months) biopsies and surgical samples were obtained from ... DisGeNET Detail
Here, we evaluate telomere lengths within 48 primary ILCs with complete characterization of estrogen... DisGeNET Detail
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Activation of G-protein coupled estrogen receptor inhibits the proliferation of cervical cancer cell... DisGeNET Detail
Significantly, despite clinical, epidemiological, and animal model results linking estrogen and estr... DisGeNET Detail
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US abnormalities were independent of ePsA clinical indices (except erosions - even if represented on... DisGeNET Detail
Independent adverse prognostic significance was retained in multivariable analysis for absence of ne... DisGeNET Detail
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Nevertheless, on analyzing OCD subphenotypes, SNP rs34535804 in ESR1 and a five SNPs haplotype, loca... DisGeNET Detail
Nevertheless, on analyzing OCD subphenotypes, SNP rs34535804 in ESR1 and a five SNPs haplotype, loca... DisGeNET Detail
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Effect of estrogen receptor gene ESR1 polymorphism on development of premenstrual syndrome. DisGeNET Detail
In context of functional enrichment analysis, interestingly candidate disease-associated genes were ... DisGeNET Detail
Deciphering how this pathway is regulated and how FASTKD2 initiates the apoptotic response will allo... DisGeNET Detail
We used this strategy to screen several commercially-available chemical libraries, identifying thirt... DisGeNET Detail
While high doses of estrogen, in combination with androgens, can initiate prostate cancer (PCa) via ... DisGeNET Detail
The present study shows that Slug has an inverse relationship with ERα in breast and prostate cancer... DisGeNET Detail
Genistein has protective effects against prostate cancer (PCa) but whether this protection involves ... DisGeNET Detail
Here we report that a novel type of transfer RNA (tRNA)-derived small RNA, termed Sex HOrmone-depend... DisGeNET Detail
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Hypercoagulability in adolescent girls on oral contraceptives-global coagulation profile and estroge... DisGeNET Detail
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Association between the ESR1 -351A>G single nucleotide polymorphism (rs9340799) and adolescent idiop... DisGeNET Detail
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The expression of HuR and estrogen receptor alpha (ER-α) protein was examined by immunohistochemistr... DisGeNET Detail
To characterize model cell lines of endometrial cancer, we determined the expression profiles of the... DisGeNET Detail
Stimulation of peroxisome proliferator-activated receptor γ inhibits estrogen receptor α transcripti... DisGeNET Detail
Our study revealed novel molecular mechanisms underlying the regulation of ERα protein homeostasis i... DisGeNET Detail
HNRNP G and HTRA2-BETA1 regulate estrogen receptor alpha expression with potential impact on endomet... DisGeNET Detail
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Being highly obese, however, was inversely associated with ESR1 expression (adjusted mean difference... DisGeNET Detail
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In this case-control study (830 non-small cell lung carcinoma (NSCLC) patients; 1119 controls) we ev... DisGeNET Detail
In this study, OS cell MG-63 was treated with low (1 nM) or high (100 nM) dose of 17β-Estradiol (E2)... DisGeNET Detail
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The estrogen receptor α gene (XbaI, PvuII) polymorphisms and susceptibility to idiopathic scoliosis:... DisGeNET Detail
Estrogen receptor 2 gene polymorphism in idiopathic scoliosis. DisGeNET Detail
However, our results suggest that promoter usage of ERα may contribute to its expression in normal d... DisGeNET Detail
The BCL9-2 proto-oncogene governs estrogen receptor alpha expression in breast tumorigenesis. DisGeNET Detail
RIP140, a regulator of estrogen receptor, recently has been found to be involved in the tumorigenesi... DisGeNET Detail
Ctr9, a key subunit of PAFc, affects global estrogen signaling and drives ERα-positive breast tumori... DisGeNET Detail
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In context of functional enrichment analysis, interestingly candidate disease-associated genes were ... DisGeNET Detail
Deciphering how this pathway is regulated and how FASTKD2 initiates the apoptotic response will allo... DisGeNET Detail
We used this strategy to screen several commercially-available chemical libraries, identifying thirt... DisGeNET Detail
While high doses of estrogen, in combination with androgens, can initiate prostate cancer (PCa) via ... DisGeNET Detail
The present study shows that Slug has an inverse relationship with ERα in breast and prostate cancer... DisGeNET Detail
Genistein has protective effects against prostate cancer (PCa) but whether this protection involves ... DisGeNET Detail
Here we report that a novel type of transfer RNA (tRNA)-derived small RNA, termed Sex HOrmone-depend... DisGeNET Detail
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Interestingly, loss of PGC1α/TFAM and ERα was found also in a non-clear cell EOC cell line made high... DisGeNET Detail
The mRNA level for FOXP1 and ERβ in ovarian carcinoma tissues decreased, while the expression level ... DisGeNET Detail
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Knockdown of MEP50 retarded cell growth and migration in selected lung cancer cell lines, which expr... DisGeNET Detail
The overall analysis showed that higher expression of ALDH1A1 is associated with larger tumor size, ... DisGeNET Detail
In addition, significant associations were also observed between TNFRSF1A polymorphisms and lymph no... DisGeNET Detail
The reduced RASA1 expression was significantly associated with tumor lymph node metastasis (P=0.002)... DisGeNET Detail
LOH in THRB was associated with negative estrogen receptor (ER), negative progesterone receptor (PR)... DisGeNET Detail
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In contrast, E2 could exert protective effects in cancer cells by activating apoptosis when the ERβ ... DisGeNET Detail
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Estrogen receptor alpha prevents bladder cancer via INPP4B inhibited akt pathway in vitro and in viv... DisGeNET Detail
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We conclude that together with LHS, ER may be considered a useful tool for evaluating the progressio... DisGeNET Detail
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Genetic polymorphisms in ESR1 and ESR2 genes, and risk of hypospadias in a multiethnic study populat... DisGeNET Detail
The enhanced severity of anaphylaxis in female mice was eliminated after pretreatment with an estrog... DisGeNET Detail
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The differential regulation of miR-29b by S100A7 in ER-positive and ER-negative breast cancer is sup... DisGeNET Detail
These biomarkers are routinely tested for in all invasive breast carcinomas; ER testing is also perf... DisGeNET Detail
In this study, we analyzed TGFβ receptor type 2 (TGFBR2) expression and correlated it with ERα statu... DisGeNET Detail
Selection criteria for study/center inclusion were estrogen receptor (ER) status or grade data avail... DisGeNET Detail
Adjuvant treatment for early stage, estrogen receptor (ER) positive invasive breast cancer has been ... DisGeNET Detail
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With the purpose of evaluating their effect on breast cancer biology, o,p'-DDT, p,p'-DDE, and p,p'-D... DisGeNET Detail
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Molecular transitions from papillomavirus infection to cervical precancer and cancer: Role of stroma... DisGeNET Detail
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Microarray-based gene expression and Affymetrix SNP 6.0 gene copy number profiling, and RNA-sequenci... DisGeNET Detail
Pre- and on-treatment (after 2 weeks and 3 months) biopsies and surgical samples were obtained from ... DisGeNET Detail
We analyzed the changes in mitochondrial DNA (mtDNA) copy numbers and the shifting of mtDNA D310 seq... DisGeNET Detail
Inhibitory effects of aromatase inhibitor on estrogen receptor-alpha positive ovarian cancer in mice... DisGeNET Detail
Importantly, this BTB mediated inhibition of ER activity is selective since BTB does not suppress th... DisGeNET Detail
BRCA mutations were detected in 26 of 92 patients (28%) with ovarian cancer, in 14 of 96 patients (1... DisGeNET Detail
E2-ERα activates all three arms of the UPR in breast and ovarian cancer cells in culture and in a mo... DisGeNET Detail
Using screening and functional validation, we identified BHPI, a potent noncompetitive small molecul... DisGeNET Detail
Effect of fenhexamid and cyprodinil on the expression of cell cycle- and metastasis-related genes vi... DisGeNET Detail
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Aberrant promoter methylation of IGSF4, DAPK1, and ESR1 genes, known to be methylated in head and ne... DisGeNET Detail
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Estrogen receptor-alpha polymorphism in patients with and without degenerative disease of the tempor... DisGeNET Detail
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DNA methyltransferase 1/3a overexpression in sporadic breast cancer is associated with reduced expre... DisGeNET Detail
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The G-protein-coupled estrogen receptor (GPER/GPR30) in ovarian granulosa cell tumors. DisGeNET Detail
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Thus, a deeper analysis of ERs could elucidate the role of estrogen in age-related cognitive changes... DisGeNET Detail
Pre- and on-treatment (after 2 weeks and 3 months) biopsies and surgical samples were obtained from ... DisGeNET Detail
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Herein, we probed estrogen receptor-α (ER) and progesterone receptor (PR) cross-talk in breast cance... DisGeNET Detail
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Independent adverse prognostic significance was retained in multivariable analysis for absence of ne... DisGeNET Detail
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The aim of this study was to evaluate the association of CYP2D6*10 (c.100C>T and c.1039C>T), OATP1B1... DisGeNET Detail
ECCCs had SCA-like features with rare expression of estrogen receptor/progesterone receptor (18.8%/6... DisGeNET Detail
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Deciphering how this pathway is regulated and how FASTKD2 initiates the apoptotic response will allo... DisGeNET Detail
Accordingly, it decreased expression of ER-α target PS2 (P<0.01) and increased expression of ER-β ta... DisGeNET Detail
Genetic polymorphisms in ESR1 and ESR2 genes, and risk of hypospadias in a multiethnic study populat... DisGeNET Detail
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Estrogenic endocrine disruptors acting via estrogen receptors α (ESR1) and β (ESR2) have been implic... DisGeNET Detail
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To characterize model cell lines of endometrial cancer, we determined the expression profiles of the... DisGeNET Detail
Our study revealed novel molecular mechanisms underlying the regulation of ERα protein homeostasis i... DisGeNET Detail
HNRNP G and HTRA2-BETA1 regulate estrogen receptor alpha expression with potential impact on endomet... DisGeNET Detail
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AYA survival was worse for female breast cancer (regardless of estrogen receptor status), acute lymp... DisGeNET Detail
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Inhibition of hepatocellular carcinoma by fulvestrant involves the estrogen receptor α and Wnt pathw... DisGeNET Detail
Western blot analysis indicated that estrogen receptor-α (ERα) was downregulated in HCC tissues and ... DisGeNET Detail
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ERα is highly expressed in female hPASMCs from PAH patients and mediates oestrogen-induced prolifera... DisGeNET Detail
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Triple-negative breast cancers (TNBC) are defined as not having amplification of the estrogen recept... DisGeNET Detail
Triple-negative breast cancer (TNBC) is a distinct breast cancer subtype defined by the absence of e... DisGeNET Detail
Triple-negative breast cancer (TNBC) is a clinically aggressive subtype of breast cancer commonly re... DisGeNET Detail
Triple negative breast cancer (TNBC) and often basal-like cancers are defined as negative for estrog... DisGeNET Detail
Triple-negative breast cancer (TNBC) is defined by reduced expression of the estrogen receptor, prog... DisGeNET Detail
Triple-negative breast cancer (TNBC) is a subgroup of breast cancers that by definition lack express... DisGeNET Detail
Triple-negative breast cancers (TNBC), negative for estrogen receptor, progesterone receptor, and ER... DisGeNET Detail
Previous studies report an association between activation of the UPR and reduced sensitivity to anti... DisGeNET Detail
The reduced RASA1 expression was significantly associated with tumor lymph node metastasis (P=0.002)... DisGeNET Detail
Particularly breast cancers, which do not express estrogen receptor α (ERα) and progesterone recepto... DisGeNET Detail
Triple negative breast cancers (TNBCs) are defined by the lack of estrogen receptor (ER), progestero... DisGeNET Detail
Due to the lack of ERα, triple negative breast cancers (TNBCs) are not susceptible to endocrine ther... DisGeNET Detail
HDAC inhibition does not induce estrogen receptor in human triple-negative breast cancer cell lines ... DisGeNET Detail
Well-known risk factors for ER-positive cancers, such as reproductive history and hormonal factors, ... DisGeNET Detail
Despite these advances, vexing clinical challenges remain particularly related to the treatment of t... DisGeNET Detail
Triple-negative breast cancer (TNBC) is defined by the absence of expression of the estrogen recepto... DisGeNET Detail
Our results show that PSMC3IP and EPSTI1 are able to modulate the extrinsic apoptotic pathway in est... DisGeNET Detail
Triple negative breast cancer (TNBC) represents approximately 15% of breast cancers and is character... DisGeNET Detail
Of the 122 patients with subtypes available, 41 patients (31%) were classified as estrogen receptor ... DisGeNET Detail
Positive immunostaining for USP2 was detected in breast tumors and was correlated with estrogen rece... DisGeNET Detail
Triple negative breast cancer (TNBC) is a distinct breast cancer subtype, which is defined by the ab... DisGeNET Detail
Characterization of macrophage--cancer cell crosstalk in estrogen receptor positive and triple-negat... DisGeNET Detail
Furthermore, whereas MEL-18 loss in luminal breast cancer cells resulted in the downregulation of ex... DisGeNET Detail
High-throughput technologies allow deepening into the molecular architecture of breast cancer, integ... DisGeNET Detail
We applied DERA to identify key regulations in triple negative breast cancer (TNBC), which is charac... DisGeNET Detail
We examined the effect of a synthetic REV-ERB agonist, SR9011, on a range of estrogen receptor posit... DisGeNET Detail
Since TNBC lacks expression of ERα, PR and HER2, existing targeted treatments are not effective and ... DisGeNET Detail
As a result of the 2010 American Society of Clinical Oncology (ASCO)/College of American Pathologist... DisGeNET Detail
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ERα is highly expressed in female hPASMCs from PAH patients and mediates oestrogen-induced prolifera... DisGeNET Detail
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Twenty-one articles identified genes associated with DOR: one gene mutation (FMR1), three polymorphi... DisGeNET Detail
Estrogenic endocrine disruptors acting via estrogen receptors α (ESR1) and β (ESR2) have been implic... DisGeNET Detail
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In the validation study using Stage I of the 2,273 cases and 2,052 controls, seven GWAS-identified l... DisGeNET Detail
In the validation study using Stage I of the 2,273 cases and 2,052 controls, seven GWAS-identified l... DisGeNET Detail
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Some studies have shown that activation of estrogen and estrogen receptor α or β (ERα/β) promote ade... DisGeNET Detail
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Aromatase inhibitors (AIs) are the standard endocrine therapy for postmenopausal breast cancer; howe... DisGeNET Detail
Aromatase inhibitor (AI) treatment is first-line systemic treatment for the majority of postmenopaus... DisGeNET Detail
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G protein-coupled estrogen receptor protects from atherosclerosis. DisGeNET Detail
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G protein-coupled estrogen receptor protects from atherosclerosis. DisGeNET Detail
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Estrogen receptor alpha prevents bladder cancer via INPP4B inhibited akt pathway in vitro and in viv... DisGeNET Detail
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NA DisGeNET Detail
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In contrast, E2 could exert protective effects in cancer cells by activating apoptosis when the ERβ ... DisGeNET Detail
To characterize model cell lines of endometrial cancer, we determined the expression profiles of the... DisGeNET Detail
Our study revealed novel molecular mechanisms underlying the regulation of ERα protein homeostasis i... DisGeNET Detail
HNRNP G and HTRA2-BETA1 regulate estrogen receptor alpha expression with potential impact on endomet... DisGeNET Detail
AYA survival was worse for female breast cancer (regardless of estrogen receptor status), acute lymp... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
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Molecular aberrations affecting the PI3K pathway may play a role in the progression from high-grade ... DisGeNET Detail
These biomarkers are routinely tested for in all invasive breast carcinomas; ER testing is also perf... DisGeNET Detail
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Melatonin exhibits oncostatic activity in several cancers but does not lead to cytotoxicity in estro... DisGeNET Detail
Estrogen receptor 1 gene expression and its combination with estrogen receptor 2 or aromatase expres... DisGeNET Detail
SNAI2/SLUG and estrogen receptor mRNA expression are inversely correlated and prognostic of patient ... DisGeNET Detail
Microarray-based gene expression and Affymetrix SNP 6.0 gene copy number profiling, and RNA-sequenci... DisGeNET Detail
Expression analysis of the estrogen receptor target genes in renal cell carcinoma. DisGeNET Detail
The levels of Smad4 and forkhead box protein H1 (FOXH1) mRNA were reduced, while the levels of estro... DisGeNET Detail

Overlapped Transcript Coordinates

Gene Transcript ID Exon Number Chromosome Start Stop Type Amino Mutation Transcript Position Links

Overlapped Transcript

Gene Transcript ID Chromosome Start Stop Links
Gene
-
dbSNP
rs34535804 dbSNP
Genome
hg19
Position
chr6:152,011,631-152,450,754
Variant Type
snv
Genome browser