chr14:62162231:> Detail (hg19)
Information
Genome
| Assembly | Position |
|---|---|
| hg19 | chr14:62,162,231-62,214,977 |
| hg38 | chr14:61,695,513-61,748,259 |
HGVS
| Type | Transcript | Protein |
|---|---|---|
Summary
MGeND
| Clinical significance | |
| Variant entry | |
| GWAS entry | |
| Disease area statistics | Show details |
Frequency
[No Data.]
Prediction
[No Data.]
ClinVar
| Clinical Significance | |
| Review star | [No Data.] |
| Show details | |
Links
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
[No Data.]
CIViC
[No Data.]
DisGeNET
| Score | Disease name | Description | Source | Pubmed | Links |
|---|---|---|---|---|---|
| 0.015 | squamous cell carcinoma | Regulation of HIF-1 alpha by the proprotein convertases furin and PC7 in human s... | BeFree,GAD,LHGDN | 24436242 | Detail |
| 0.015 | squamous cell carcinoma | Our results show the potential use of LCP nanoparticles for efficient delivery o... | BeFree,GAD,LHGDN | 25596376 | Detail |
| 0.015 | squamous cell carcinoma | Epidermal growth factor receptor inhibition reduces angiogenesis via hypoxia-ind... | BeFree,GAD,LHGDN | 25723392 | Detail |
| 0.006 | Carcinoma, Transitional Cell | NA | BeFree,GAD,LHGDN | Detail | |
| 0.003 | Cardiovascular Diseases | NA | BeFree,GAD | Detail | |
| <0.001 | carotid stenosis | NA | BeFree | Detail | |
| <0.001 | celiac disease | NA | BeFree | Detail | |
| 0.002 | cellulitis | NA | GAD | Detail | |
| 0.001 | cerebral infarction | Mutant hypoxia-inducible factor 1α modified bone marrow mesenchymal stem cells a... | BeFree | 25270619 | Detail |
| 0.004 | Squamous cell carcinoma of the head and neck | We assessed the difference in transcription activity of two HIF-1alpha polymorph... | BeFree | 12919954 | Detail |
| 0.015 | Malignant neoplasm of pancreas | Our findings suggest that the HIF-1α A588T polymorphism is significantly associa... | BeFree | 24293391 | Detail |
| 0.015 | pancreatic carcinoma | Our findings suggest that the HIF-1α A588T polymorphism is significantly associa... | BeFree | 24293391 | Detail |
| <0.001 | Malignant neoplasm of gastrointestinal tract | To understand the role of HIF-1α P582S and A588T genotypes in digestive cancer d... | BeFree | 24293391 | Detail |
| 0.019 | prostate carcinoma | The current findings suggest that HIF1A P582S polymorphism correlates with urina... | BeFree | 23723982 | Detail |
| <0.001 | Cancer of Digestive System | HIF-1α P582S and A588T polymorphisms and digestive system cancer risk-a meta-ana... | BeFree | 24293391 | Detail |
| 0.022 | Tumor Progression | Hypoxia-inducible factor-1 (HIF-1) influences cancer progression and metastasis ... | BeFree | 24293391 | Detail |
| 0.027 | Malignant neoplasm of prostate | The current findings suggest that HIF1A P582S polymorphism correlates with urina... | BeFree | 23723982 | Detail |
| <0.001 | breast adenocarcinoma | We aimed to study the prevalence of Hypoxia inducible factor-1α (HIF-1α) P582S a... | BeFree | 23749907 | Detail |
| 0.037 | renal cell carcinoma | In previous studies, the C1772T (P582S) or the G1790A (A588T) polymorphisms of t... | BeFree | 18949419 | Detail |
| 0.027 | Malignant neoplasm of prostate | In previous studies, the C1772T (P582S) or the G1790A (A588T) polymorphisms of t... | BeFree | 18949419 | Detail |
| 0.051 | Neoplasm Metastasis | Hypoxia-inducible factor-1 (HIF-1) influences cancer progression and metastasis ... | BeFree | 24293391 | Detail |
| 0.200 | brain ischemia | NA | BeFree,CTD_human,RGD | Detail | |
| 0.080 | Transient ischemic attack | NA | RGD | Detail | |
| 0.120 | Cholangitis, Sclerosing | NA | CTD_human | Detail | |
| 0.004 | chondrosarcoma | The effects of hypoxia and hypoxia-inducible factor-1α (HIF-1α) transfection and... | BeFree,LHGDN | 25106798 | Detail |
| <0.001 | chordoma | NA | BeFree | Detail | |
| 0.001 | colitis | NA | BeFree | Detail | |
| 0.014 | Colonic Neoplasms | NA | BeFree,LHGDN | Detail | |
| 0.010 | colorectal carcinoma | Prognostic potential of DNA methylation and transcript levels of HIF1A and EPAS1... | BeFree | 24825851 | Detail |
| 0.010 | colorectal carcinoma | Taken together, our data demonstrate for the first time that inhibition of HSP90... | BeFree | 24861206 | Detail |
| 0.010 | colorectal carcinoma | Genetic variations in the HIF1A gene modulate response to adjuvant chemotherapy ... | BeFree | 24969897 | Detail |
| 0.010 | colorectal carcinoma | This article reviews the central role of HIF1α in CRC angiogenesis, metastasis, ... | BeFree | 26116902 | Detail |
| 0.010 | colorectal carcinoma | HIF-1α in colorectal carcinoma: review of the literature. | BeFree | 26214618 | Detail |
| 0.017 | Colorectal Neoplasms | NA | BeFree,LHGDN | Detail | |
| 0.002 | Coronary Arteriosclerosis | NA | BeFree | Detail | |
| 0.001 | Coronary heart disease | NA | BeFree | Detail | |
| <0.001 | Coronary Vessel Anomalies | NA | BeFree | Detail | |
| <0.001 | adenoid cystic carcinoma | The data indicate that the overexpression of survivin in AdCC is related to HIF-... | BeFree | 25485635 | Detail |
| 0.003 | cystic fibrosis | NA | BeFree,LHGDN | Detail | |
| 0.003 | Phyllodes Tumor | The purpose of this study is to investigate the expression of succinate dehydrog... | BeFree,LHGDN | 24807638 | Detail |
| 0.080 | Pressure Ulcer | NA | RGD | Detail | |
| 0.002 | Diabetes | NA | BeFree | Detail | |
| 0.002 | diabetes mellitus | NA | BeFree | Detail | |
| 0.080 | Diabetes Mellitus, Experimental | NA | RGD | Detail | |
| 0.086 | Diabetes Mellitus, Non-Insulin-Dependent | NA | BeFree,GAD,RGD | Detail | |
| 0.081 | Diabetic Nephropathy | NA | BeFree,RGD | Detail | |
| 0.083 | diabetic retinopathy | NA | BeFree,GAD,RGD | Detail | |
| <0.001 | eclampsia | We studied the effect of pre-eclampsia sera on the expression of placenta growth... | BeFree | 25132343 | Detail |
| 0.005 | Endometrial Neoplasms | NA | LHGDN | Detail | |
| <0.001 | endometriosis | This aberrant activation of pSTAT3 and HIF1A is confirmed by sequential analysis... | BeFree | 25750101 | Detail |
| <0.001 | epilepsy | We aimed to investigate the expression of HIF-1α and MDR1/P-glycoprotein in refr... | BeFree | 24590840 | Detail |
| <0.001 | Epilepsy, Temporal Lobe | These results demonstrated the overexpression of HIF-1α and MDR1/Pgp in hippocam... | BeFree | 24590840 | Detail |
| 0.003 | Esophageal Neoplasms | NA | BeFree,LHGDN | Detail | |
| <0.001 | Fatty Liver | NA | BeFree | Detail | |
| 0.001 | fibrosarcoma | NA | BeFree | Detail | |
| <0.001 | gastritis | Myeloid HIF-1 is protective in Helicobacter pylori-mediated gastritis. | BeFree | 25710915 | Detail |
| 0.134 | glioblastoma | Treating glioblastoma with siRNA targeting HIF-1α in vivo can significantly redu... | BeFree,CTD_human,LHGDN | 25423275 | Detail |
| 0.134 | glioblastoma | Given the role of HIF-1α in cell migration, we conclude that the attenuation of ... | BeFree,CTD_human,LHGDN | 25511738 | Detail |
| 0.134 | glioblastoma | Hypoxia enhances migration and invasion in glioblastoma by promoting a mesenchym... | BeFree,CTD_human,LHGDN | 25592037 | Detail |
| 0.134 | glioblastoma | Targeting Hypoxia-Inducible Factor 1α in a New Orthotopic Model of Glioblastoma ... | BeFree,CTD_human,LHGDN | 26083570 | Detail |
| 0.026 | Glioma | We used human glioma tissues and derived brain tumor stem cells (BTSCs) to study... | BeFree,LHGDN | 24366912 | Detail |
| 0.026 | Glioma | The IRS of HIF-1α in the tumour did not correlate with the SUVtumour of FMISO in... | BeFree,LHGDN | 24781871 | Detail |
| 0.026 | Glioma | Silencing of HIF-1α enhances the radiation sensitivity of human glioma growth in... | BeFree,LHGDN | 24859610 | Detail |
| 0.026 | Glioma | HIF-1α genetic variants and protein expression confer the susceptibility and pro... | BeFree,LHGDN | 24929654 | Detail |
| 0.026 | Glioma | miR-184 and HIF-1α protein levels were significantly upregulated in human glioma... | BeFree,LHGDN | 25277131 | Detail |
| 0.026 | Glioma | RNA interference targeting hypoxia-inducible factor 1α via a novel multifunction... | BeFree,LHGDN | 25423275 | Detail |
| 0.026 | Glioma | Given the role of HIF-1α in cell migration, we conclude that the attenuation of ... | BeFree,LHGDN | 25511738 | Detail |
| 0.026 | Glioma | The HIF-1α-p75NTR-EMT axis may play a central role in glioma tumorigenesis. | BeFree,LHGDN | 25527128 | Detail |
| 0.026 | Glioma | Hypoxia-inducible factor 1α (HIF-1α) activity is one of the major players in hyp... | BeFree,LHGDN | 25813354 | Detail |
| 0.080 | Glycogen Storage Disease Type V | NA | MGD | Detail | |
| 0.080 | Glycogen Storage Disease Type VII | NA | MGD | Detail | |
| <0.001 | Graves Disease | NA | BeFree | Detail | |
| 0.003 | Head and Neck Neoplasms | NA | LHGDN | Detail | |
| <0.001 | cardiac arrest | NA | BeFree | Detail | |
| 0.120 | congenital heart defects | NA | CTD_human | Detail | |
| 0.120 | Cardiomegaly | NA | CTD_human | Detail | |
| 0.201 | Heart failure | NA | BeFree,CTD_human,RGD | Detail | |
| 0.001 | congestive heart failure | NA | BeFree | Detail | |
| <0.001 | hemangioma | Moreover, the protein levels of VEGF, phosphorylated STAT3, total STAT3 and Bcl-... | BeFree | 25872592 | Detail |
| 0.080 | hepatic encephalopathy | NA | RGD | Detail | |
| 0.003 | hepatitis | NA | LHGDN | Detail | |
| 0.006 | hepatitis B | Two polymorphisms in the HIF-1a gene (rs11549465 and rs115494657>rs115494657) we... | BeFree,LHGDN | 25195037 | Detail |
| 0.006 | hepatitis B | Association between hypoxia-inducible factor-1α gene polymorphisms and risk of c... | BeFree,LHGDN | 25824382 | Detail |
| 0.005 | Von Hippel-Lindau syndrome | We performed immunohistochemical studies on 23 hemangioblastomas, 13 meningiomas... | BeFree | 25310734 | Detail |
| 0.005 | Von Hippel-Lindau syndrome | Low oxygen tension or von Hippel-Lindau (Vhl) tumor suppressor loss is known to ... | BeFree | 25440060 | Detail |
| 0.005 | Von Hippel-Lindau syndrome | In normoxia, knockdown of JMJD6 in JEG3 cells stabilized HIF1A with a concomitan... | BeFree | 26037477 | Detail |
| <0.001 | HIV Infections | NA | BeFree | Detail | |
| 0.003 | Hodgkin Disease | NA | BeFree,LHGDN | Detail | |
| 0.080 | Hyperalgesia | NA | RGD | Detail | |
| 0.002 | hyperglycemia | NA | BeFree | Detail | |
| <0.001 | hyperinsulinism | NA | BeFree | Detail | |
| 0.123 | Hyperplasia | NA | CTD_human,LHGDN | Detail | |
| 0.204 | Hypertensive disease | Dysregulation of HIF-1- and HIF-2-mediated transcription leads to imbalance of p... | BeFree,CTD_human,LHGDN,RGD | 25772710 | Detail |
| 0.204 | Hypertensive disease | Accumulation of hypoxia inducible factor-1α (HIF-1α) is commonly an acute and be... | BeFree,CTD_human,LHGDN,RGD | 25847948 | Detail |
| 0.202 | pulmonary hypertension | Hypoxia- or PDGF-BB-dependent paxillin tyrosine phosphorylation in pulmonary hyp... | BeFree,CTD_human,RGD | 25231004 | Detail |
| 0.202 | pulmonary hypertension | We revealed that overexpression of HEXIM1 prevented hypoxia-induced expression o... | BeFree,CTD_human,RGD | 25301555 | Detail |
| 0.202 | pulmonary hypertension | These observations suggest that altered glucose metabolism and G6PD overactivati... | BeFree,CTD_human,RGD | 25480333 | Detail |
| 0.202 | pulmonary hypertension | We also demonstrated that Pyk2 plays a crucial role in ROS generation during hyp... | BeFree,CTD_human,RGD | 25659487 | Detail |
| <0.001 | hypoglycemia | NA | BeFree | Detail | |
| 0.080 | Infarction | NA | RGD | Detail | |
| <0.001 | Mammary Ductal Carcinoma | To give a translational significance to the study, we took into consideration hu... | BeFree | 25447306 | Detail |
| 0.003 | Inflammation | NA | LHGDN | Detail | |
| <0.001 | Inflammatory Bowel Diseases | NA | BeFree | Detail | |
| <0.001 | intermittent claudication | NA | BeFree | Detail | |
| <0.001 | Intestinal Neoplasms | NA | BeFree | Detail | |
| 0.020 | ischemia | In present study, we determined the promotion of HIF-1α and survivin in brain sa... | BeFree,LHGDN | 25339014 | Detail |
| <0.001 | Keloid | In conclusion, the present findings demonstrate that the hypoxia/HIF-1α microenv... | BeFree | 25777304 | Detail |
| 0.001 | Kidney Diseases | NA | BeFree | Detail | |
| <0.001 | Kidney Failure, Acute | NA | BeFree | Detail | |
| 0.003 | Kidney Failure, Chronic | In a rat model of chronic renal failure, the known increase in hepatic OSTα expr... | BeFree,GAD | 24703425 | Detail |
| 0.006 | Kidney Neoplasm | NA | BeFree,GAD,LHGDN | Detail | |
| <0.001 | acute kidney tubular necrosis | NA | BeFree | Detail | |
| 0.080 | Polycystic Kidney Diseases | NA | RGD | Detail | |
| <0.001 | Fibroid Tumor | NA | BeFree | Detail | |
| 0.007 | leukemia | Modulation of mRNA expression of several hypoxia-related genes was also observed... | BeFree,LHGDN | 24160851 | Detail |
| 0.007 | leukemia | Thus high HIF1α expression serves as a reliable marker, which identifies patient... | BeFree,LHGDN | 25727291 | Detail |
| <0.001 | chronic lymphocytic leukemia | NA | BeFree | Detail | |
| <0.001 | Leukemia, Lymphocytic, Acute, L1 | In gene expression analysis, low oxygen levels promoted HIF1A activation in a ti... | BeFree | 24160851 | Detail |
| 0.002 | Leukemia, Myelocytic, Acute | Thus high HIF1α expression serves as a reliable marker, which identifies patient... | BeFree | 25727291 | Detail |
| <0.001 | Myeloid Leukemia, Chronic | NA | BeFree | Detail | |
| <0.001 | acute promyelocytic leukemia | NA | BeFree | Detail | |
| <0.001 | Leukoencephalopathy, Progressive Multifocal | NA | BeFree | Detail | |
| 0.003 | liver cirrhosis | Association between hypoxia-inducible factor-1α gene polymorphisms and risk of c... | BeFree,GAD | 25824382 | Detail |
| 0.120 | Biliary cirrhosis | NA | CTD_human | Detail | |
| 0.080 | Alcoholic Liver Diseases | NA | RGD | Detail | |
| 0.009 | Liver neoplasms | Of the ten miRNAs predicted by the 3'-UTR of HIF-1α mRNA, PPIX treatment increas... | BeFree,GAD | 25714015 | Detail |
| 0.120 | Lung diseases | NA | BeFree,CTD_human | Detail | |
| <0.001 | Chronic Obstructive Airway Disease | And this is the first time the HIF1A polymorphisms in COPD in a Chinese populati... | BeFree | 25565795 | Detail |
| 0.007 | Lung Neoplasms | NA | BeFree,LHGDN | Detail | |
| 0.003 | Lymphatic Metastasis | HIF-1α and Sema4D expression are closely related to lymphatic metastasis, specif... | BeFree,GAD | 25316231 | Detail |
| <0.001 | Lymphohistiocytosis, Hemophagocytic | NA | BeFree | Detail | |
| 0.004 | lymphoma | NA | BeFree,LHGDN | Detail | |
| <0.001 | Lymphoma, Non-Hodgkin | NA | BeFree | Detail | |
| 0.011 | Malignant neoplasm of stomach | Altered expression of hypoxia-inducible factor-1α (HIF-1α) and its regulatory ge... | BeFree | 24927122 | Detail |
| 0.011 | Malignant neoplasm of stomach | Overexpression of different PFKFB in pancreatic and gastric cancer cells under h... | BeFree | 25320508 | Detail |
| 0.080 | Mammary Neoplasms, Experimental | NA | RGD | Detail | |
| <0.001 | medulloblastoma | NA | BeFree | Detail | |
| <0.001 | Melanoma, Experimental | NA | BeFree | Detail | |
| 0.003 | meningioma | NA | LHGDN | Detail | |
| 0.003 | Mesothelioma | NA | LHGDN | Detail | |
| 0.003 | Metabolic Diseases | NA | LHGDN | Detail | |
| <0.001 | Mixed Salivary Gland Tumor | NA | BeFree | Detail | |
| 0.002 | Mouth Neoplasms | NA | GAD | Detail | |
| <0.001 | Mucocutaneous Lymph Node Syndrome | NA | BeFree | Detail | |
| 0.003 | multiple myeloma | In addition, the combination of VEGF siRNA and everolimus significantly reversed... | BeFree | 24903015 | Detail |
| 0.003 | multiple myeloma | Rosiglitazone suppresses angiogenesis in multiple myeloma via downregulation of ... | BeFree | 25050627 | Detail |
| 0.003 | multiple myeloma | We show the unprecedented role of the metabolic phenotype in inducing drug resis... | BeFree | 25769724 | Detail |
| <0.001 | multiple sclerosis | NA | BeFree | Detail | |
| <0.001 | Mycoses | Additionally, this work supports the strategy of exploring HIF1α as a therapeuti... | BeFree | 25255025 | Detail |
| 0.081 | myocardial infarction | NA | BeFree,RGD | Detail | |
| 0.200 | Myocardial Reperfusion Injury | NA | CTD_human,RGD | Detail | |
| 0.122 | Neoplasm Invasiveness | NA | CTD_human,GAD | Detail | |
| 0.051 | Neoplasm Metastasis | Furthermore, coexpression of HIF-1α and CXCR4 was significantly higher in patien... | BeFree,LHGDN | 24618817 | Detail |
| 0.051 | Neoplasm Metastasis | TNCL increased the expression of several oncogenes, including MMP9, anaplastic l... | BeFree,LHGDN | 24632608 | Detail |
| 0.051 | Neoplasm Metastasis | Epithelial to mesenchymal transition (EMT), invasion, and motility are essential... | BeFree,LHGDN | 24861206 | Detail |
| 0.051 | Neoplasm Metastasis | Hypoxia-inducible factor 1α (HIF-1α) plays an important role in regulating cell ... | BeFree,LHGDN | 24969897 | Detail |
| 0.051 | Neoplasm Metastasis | The results of this study reveal a novel role for miR-18a in targeting HIF1A and... | BeFree,LHGDN | 25069832 | Detail |
| 0.051 | Neoplasm Metastasis | Tumor microenvironmental hypoxia induces hypoxia inducible factor-1α (HIF-1α) ov... | BeFree,LHGDN | 25238333 | Detail |
| 0.051 | Neoplasm Metastasis | HIF-1α promotes HCC progression and metastasis by upregulating CXCL6 transcripti... | BeFree,LHGDN | 25323032 | Detail |
| 0.051 | Neoplasm Metastasis | They function differently in different cancers with specific mechanisms. p53 and... | BeFree,LHGDN | 25341508 | Detail |
| 0.051 | Neoplasm Metastasis | LASP1 is a HIF1α target gene critical for metastasis of pancreatic cancer. | BeFree,LHGDN | 25385028 | Detail |
| 0.051 | Neoplasm Metastasis | HIF-1α mediates hypoxia-induced expression of the chemokine receptor CXCR4 and c... | BeFree,LHGDN | 25444927 | Detail |
| 0.051 | Neoplasm Metastasis | We highlighted the importance of nuclear HIF-1α in the biology of metastasis for... | BeFree,LHGDN | 25447306 | Detail |
| 0.051 | Neoplasm Metastasis | Intratumoral hypoxia followed by stabilization/activation of hypoxia-inducible f... | BeFree,LHGDN | 25506893 | Detail |
| 0.051 | Neoplasm Metastasis | In this study, we investigated the relationship between the expression of p75NTR... | BeFree,LHGDN | 25527128 | Detail |
| 0.051 | Neoplasm Metastasis | Hypoxia inducible factor-1 alpha (HIF-1α) plays an important role in angiogenesi... | BeFree,LHGDN | 25603055 | Detail |
| 0.051 | Neoplasm Metastasis | Our recent investigations showed that polycomb chromobox 4 (Cbx4) promotes angio... | BeFree,LHGDN | 25766328 | Detail |
| 0.051 | Neoplasm Metastasis | Functional studies showed IL-24 inhibited tumor cell migration and invasion conc... | BeFree,LHGDN | 25775124 | Detail |
| 0.051 | Neoplasm Metastasis | The expression of the transcription factor, hypoxia-inducible factor-1α (HIF-1α)... | BeFree,LHGDN | 25777304 | Detail |
| 0.051 | Neoplasm Metastasis | HIF-1α drives miR-210's overexpression and the resultant alteration of cellular ... | BeFree,LHGDN | 25809609 | Detail |
| 0.051 | Neoplasm Metastasis | This leads to HIF1α-mediated sarcoma cell invasion and enhanced metastatic capac... | BeFree,LHGDN | 25965573 | Detail |
| 0.051 | Neoplasm Metastasis | Hypoxia inducible factor-1α: Its role in colorectal carcinogenesis and metastasi... | BeFree,LHGDN | 26116902 | Detail |
| 0.002 | Pathologic Neovascularization | NA | GAD | Detail | |
| <0.001 | nephrosclerosis | NA | BeFree | Detail | |
| 0.080 | Neuritis, Autoimmune, Experimental | NA | RGD | Detail | |
| 0.007 | neuroblastoma | The influence of intermittent hypoxia and HIF-1α siRNA on migration of neuroblas... | BeFree,LHGDN | 25148040 | Detail |
| 0.007 | neuroblastoma | Upregulation of HIF-1α by hypoxia protect neuroblastoma cells from apoptosis by ... | BeFree,LHGDN | 25339014 | Detail |
| 0.007 | neuroblastoma | Differential regulation of HIF-1α and HIF-2α in neuroblastoma: Estrogen-related ... | BeFree,LHGDN | 25912138 | Detail |
| <0.001 | Melanocytic nevus | NA | BeFree | Detail | |
| 0.005 | obesity | NA | BeFree,GAD | Detail | |
| <0.001 | Obesity, Morbid | NA | BeFree | Detail | |
| 0.003 | oral submucous fibrosis | NA | LHGDN | Detail | |
| 0.007 | Degenerative polyarthritis | NA | BeFree,LHGDN | Detail | |
| 0.005 | Bone necrosis | NA | GAD,LHGDN | Detail | |
| 0.080 | Osteoporosis, Postmenopausal | NA | RGD | Detail | |
| 0.009 | osteosarcoma | Hypoxia promotes migration and induces CXCR4 expression via HIF-1α activation in... | BeFree,LHGDN | 24618817 | Detail |
| 0.009 | osteosarcoma | Thus, HIF-1α may be a promising drug target of resveratrol in the context of dev... | BeFree,LHGDN | 25384583 | Detail |
| 0.010 | ovarian carcinoma | Reactive oxygen species promote ovarian cancer progression via the HIF-1α/LOX/E-... | BeFree | 25174950 | Detail |
| 0.010 | ovarian carcinoma | Succinate dehydrogenase subunit B inhibits the AMPK-HIF-1α pathway in human ovar... | BeFree | 25491408 | Detail |
| 0.010 | ovarian carcinoma | In this study, we found that the expressions of HIF-1α and HIF-2α were increased... | BeFree | 25619133 | Detail |
| 0.010 | ovarian carcinoma | To elucidate the characteristics of this troublesome cancer, we examined HIF-1α ... | BeFree | 25756515 | Detail |
| 0.143 | Pancreatic Neoplasm | The aim of study was to discuss the correlation and regulatory mechanism of HIF-... | BeFree,CTD_human,LHGDN | 25119596 | Detail |
| <0.001 | paraganglioma | NA | BeFree | Detail | |
| <0.001 | peritonitis | NA | BeFree | Detail | |
| 0.001 | pheochromocytoma | NA | BeFree | Detail | |
| 0.002 | pituitary adenoma | NA | BeFree | Detail | |
| <0.001 | Pituitary Neoplasms | NA | BeFree | Detail | |
| <0.001 | pneumonia | Taken together, our data demonstrate that HIF-1α acts downstream of TNF-α to inh... | BeFree | 25051011 | Detail |
| <0.001 | Pneumoperitoneum | NA | BeFree | Detail | |
| 0.002 | polycythemia | NA | BeFree | Detail | |
| <0.001 | Adenomatous Polyposis Coli | NA | BeFree | Detail | |
| 0.003 | pre-eclampsia | NA | LHGDN | Detail | |
| <0.001 | Precancerous Conditions | NA | BeFree | Detail | |
| <0.001 | Pregnancy Complications | NA | BeFree | Detail | |
| <0.001 | Prostatic Diseases | NA | BeFree | Detail | |
| 0.153 | Prostatic Neoplasms | A well-characterized murine model of prostate cancer was used to investigate the... | BeFree,CTD_human,LHGDN | 25349289 | Detail |
| 0.153 | Prostatic Neoplasms | KLF5 loss enhances tumor angiogenesis by attenuating PI3K/AKT signaling and subs... | BeFree,CTD_human,LHGDN | 25896712 | Detail |
| <0.001 | pulmonary edema | NA | BeFree | Detail | |
| <0.001 | pulmonary emphysema | NA | BeFree | Detail | |
| <0.001 | pulmonary fibrosis | Overexpression of angiogenic factors (activation of VEGF through HIF-1A) may pre... | BeFree | 26022899 | Detail |
| 0.083 | Reperfusion Injury | NA | LHGDN,RGD | Detail | |
| <0.001 | retinal degeneration | NA | BeFree | Detail | |
| 0.002 | Retinal Diseases | Beta-lapachone inhibits pathological retinal neovascularization in oxygen-induce... | BeFree | 24533641 | Detail |
| 0.001 | retinoblastoma | Inhibition of hypoxia inducible factor 1α by siRNA-induced apoptosis in human re... | BeFree | 24860939 | Detail |
| 0.001 | retinoblastoma | To the best of our knowledge, results of the present study provide the first evi... | BeFree | 25872572 | Detail |
| 0.003 | retinopathy of prematurity | Thus, strategies blocking HIF-1α in the developing eye in the pathological hypox... | BeFree,GAD | 24533641 | Detail |
| <0.001 | rhinitis | NA | BeFree | Detail | |
| <0.001 | sarcoidosis | These findings were in line with previous data on the role of HIF-1A/VEGF/ING-4 ... | BeFree | 26022899 | Detail |
| <0.001 | Kaposi sarcoma | NA | BeFree | Detail | |
| <0.001 | schizophrenia | NA | BeFree | Detail | |
| 0.003 | systemic scleroderma | NA | BeFree,GAD | Detail | |
| <0.001 | Age-related cataract | Effect of HSF4b on age related cataract may through its novel downstream target ... | BeFree | 25088997 | Detail |
| <0.001 | Septicemia | Mechanistically, hypoxia inducible factor-1α (HIF1α) mediated this functional re... | BeFree | 25746953 | Detail |
| <0.001 | sinusitis | NA | BeFree | Detail | |
| <0.001 | Skin Diseases, Infectious | NA | BeFree | Detail | |
| 0.120 | Skin Neoplasms | NA | CTD_human | Detail | |
| <0.001 | Spinal Cord Diseases | HIF-1α polymorphism in the susceptibility of cervical spondylotic myelopathy and... | BeFree | 25401740 | Detail |
| 0.023 | Stomach Neoplasms | NA | BeFree,GAD,LHGDN | Detail | |
| 0.003 | gastric ulcer | NA | BeFree,LHGDN | Detail | |
| 0.081 | Cerebrovascular accident | Collectively, these results demonstrate that NCX1 expression is regulated by the... | BeFree,RGD | 25972164 | Detail |
| <0.001 | Sturge-Weber syndrome | NA | BeFree | Detail | |
| 0.080 | Subarachnoid Hemorrhage | NA | RGD | Detail | |
| 0.080 | Temporomandibular Joint Disorders | NA | RGD | Detail | |
| <0.001 | teratoma | NA | BeFree | Detail | |
| <0.001 | tetralogy of Fallot | NA | BeFree | Detail | |
| 0.120 | Thyroid Neoplasm | NA | CTD_human | Detail | |
| 0.003 | Tongue Neoplasms | NA | LHGDN | Detail | |
| <0.001 | tonsillitis | NA | BeFree | Detail | |
| <0.001 | Transposition of Great Vessels | NA | BeFree | Detail | |
| 0.080 | Ulcer | NA | RGD | Detail | |
| <0.001 | ureteral obstruction | NA | BeFree | Detail | |
| <0.001 | Uterine Fibroids | NA | BeFree | Detail | |
| 0.080 | varicocele | NA | RGD | Detail | |
| <0.001 | Varicose Ulcer | NA | BeFree | Detail | |
| <0.001 | Varicosity | NA | BeFree | Detail | |
| <0.001 | Vascular Diseases | NA | BeFree | Detail | |
| <0.001 | Ichthyosis, X-Linked | NA | BeFree | Detail | |
| <0.001 | Lymphoma, Large-Cell, Follicular | NA | BeFree | Detail | |
| <0.001 | T-Cell Lymphoma | NA | BeFree | Detail | |
| <0.001 | Peripheral Vascular Diseases | NA | BeFree | Detail | |
| <0.001 | severe combined immunodeficiency | NA | BeFree | Detail | |
| <0.001 | angiodysplasia | NA | BeFree | Detail | |
| <0.001 | cataract | To identify if HSF4b play it role in cataract development through HIF1α, we tran... | BeFree | 25088997 | Detail |
| <0.001 | benign neoplasm | NA | BeFree | Detail | |
| <0.001 | Spontaneous pneumothorax | NA | BeFree | Detail | |
| <0.001 | Small cell carcinoma of lung | SOCS3 blocks HIF-1α expression to inhibit proliferation and angiogenesis of huma... | BeFree | 25695729 | Detail |
| <0.001 | Adenocarcinoma of rectum | NA | BeFree | Detail | |
| <0.001 | renal fibrosis | Genetic studies coupled with reverse transcription polymerase chain reaction pro... | BeFree | 25987665 | Detail |
| 0.084 | Myocardial Ischemia | NA | BeFree,GAD,RGD | Detail | |
| <0.001 | Ulcer of esophagus | NA | BeFree | Detail | |
| 0.003 | Adenocarcinoma of lung (disorder) | NA | BeFree | Detail | |
| 0.002 | esophageal carcinoma | HIF-1α induces VE-cadherin expression and modulates vasculogenic mimicry in esop... | BeFree | 25548487 | Detail |
| 0.002 | Idiopathic pulmonary hypertension | Furthermore, using a gain and loss of function approach, we showed that increase... | BeFree | 26084306 | Detail |
| 0.001 | Malignant neoplasm of mouth | Cobalt chloride (CoCl2), a HIF-1α activator, attenuated the IK-induced growth-in... | BeFree | 25105148 | Detail |
| 0.001 | Malignant neoplasm of mouth | This meta-analysis demonstrates that both the C1772T and G1790A polymorphisms in... | BeFree | 25496056 | Detail |
| <0.001 | Malignant neoplasm of gallbladder | In this study, we have investigated the role of HIF-1α in the pathobilogy of GBC... | BeFree | 25499970 | Detail |
| 0.002 | Secondary malignant neoplasm of lung | MicroRNA-18a inhibits hypoxia-inducible factor 1α activity and lung metastasis i... | BeFree | 25069832 | Detail |
| 0.002 | Secondary malignant neoplasm of bone | Hypoxia induced E-cadherin involving regulators of Hippo pathway due to HIF-1α s... | BeFree | 25447306 | Detail |
| 0.002 | Secondary malignant neoplasm of bone | Finally, significantly less Tip110, p53, and HIF-1α was detected in the hypoxic ... | BeFree | 25939381 | Detail |
| <0.001 | acute myocardial infarction | NA | BeFree | Detail | |
| <0.001 | allergic asthma | NA | BeFree | Detail | |
| 0.080 | Intervertebral disc disorder | NA | RGD | Detail | |
| 0.003 | Colitis, Ischemic | NA | BeFree,LHGDN | Detail | |
| <0.001 | Right Ventricular Hypertrophy | Recently, proangiogenic factors hypoxia-inducible factor-1 alpha (HIF-1α) and va... | BeFree | 25301555 | Detail |
| <0.001 | Aortic Aneurysm, Abdominal | In this study, the functional variants in genes involved in the hypoxia signalin... | BeFree | 24657063 | Detail |
| <0.001 | Aortic Aneurysm, Thoracic | BRG1 is overexpressed in the aortic media of thoracic aortic aneurysms and the i... | BeFree | 24875884 | Detail |
| 0.022 | Tumor Progression | Cellular adaptation to a hypoxic microenvironment is essential for tumor progres... | BeFree | 24618817 | Detail |
| 0.022 | Tumor Progression | Increased expression of HIF-1α has also been demonstrated to be involved in tumo... | BeFree | 24969897 | Detail |
| 0.022 | Tumor Progression | As one of the major mediators of hypoxic response, hypoxia inducible factor-1 (H... | BeFree | 25101278 | Detail |
| 0.022 | Tumor Progression | HIF-1-mediated suppression of acyl-CoA dehydrogenases and fatty acid oxidation i... | BeFree | 25242319 | Detail |
| 0.022 | Tumor Progression | Resveratrol inhibits hypoxia-inducible factor-1α-mediated androgen receptor sign... | BeFree | 25297617 | Detail |
| 0.022 | Tumor Progression | This review delineates the crucial role that HIF-1α plays in carcinogenesis, tum... | BeFree | 26214618 | Detail |
| 0.022 | Tumor Progression | Cinnamic aldehyde suppresses hypoxia-induced angiogenesis via inhibition of hypo... | BeFree | 26297910 | Detail |
| <0.001 | Pneumonia, Interstitial | NA | BeFree | Detail | |
| <0.001 | Giant Cell Tumor of Bone | NA | BeFree | Detail | |
| 0.003 | Adenocarcinoma, Clear Cell | NA | BeFree,LHGDN | Detail | |
| <0.001 | Carcinoma, Endometrioid | NA | BeFree | Detail | |
| <0.001 | subependymal glioma | NA | BeFree | Detail | |
| <0.001 | Strawberry nevus of skin | NA | BeFree | Detail | |
| 0.121 | hemangioblastoma | Expression of HIF-1 regulated proteins vascular endothelial growth factor, carbo... | BeFree,CTD_human | 25310734 | Detail |
| <0.001 | Melanoma, Amelanotic | NA | BeFree | Detail | |
| <0.001 | Adult Acute Myeloblastic Leukemia | NA | BeFree | Detail | |
| 0.001 | uveal melanoma | We found expression of hypoxia-inducible factor 1α (HIF-1α) protein in well-vasc... | BeFree | 25166211 | Detail |
| 0.001 | Lip and oral cavity carcinoma | Cobalt chloride (CoCl2), a HIF-1α activator, attenuated the IK-induced growth-in... | BeFree | 25105148 | Detail |
| 0.001 | Lip and oral cavity carcinoma | This meta-analysis demonstrates that both the C1772T and G1790A polymorphisms in... | BeFree | 25496056 | Detail |
| <0.001 | Fibrillation | NA | BeFree | Detail | |
| <0.001 | gallbladder carcinoma | In this study, we have investigated the role of HIF-1α in the pathobilogy of GBC... | BeFree | 25499970 | Detail |
| 0.015 | pancreatic carcinoma | Expression of HIF-1 in pancreatic cancer cells increased under the condition of ... | BeFree | 25119596 | Detail |
| 0.015 | pancreatic carcinoma | LASP1 is a HIF1α target gene critical for metastasis of pancreatic cancer. | BeFree | 25385028 | Detail |
| 0.015 | pancreatic carcinoma | Treatment with UBS109, EF31 or curcumin inhibited HSP90, NF-κB, and HIF-1α trans... | BeFree | 25497868 | Detail |
| 0.015 | pancreatic carcinoma | LB-1 Exerts Antitumor Activity in Pancreatic Cancer by Inhibiting HIF-1α and Sta... | BeFree | 25655308 | Detail |
| 0.015 | pancreatic carcinoma | Effects of hypoxia-inducible factor-1α silencing on drug resistance of human pan... | BeFree | 25699390 | Detail |
| 0.015 | pancreatic carcinoma | The effect of lentiviral vector-mediated RNA interference targeting hypoxia-indu... | BeFree | 25853522 | Detail |
| <0.001 | Carcinoma of male breast | NA | BeFree | Detail | |
| <0.001 | Gastrointestinal Stromal Tumors | NA | BeFree | Detail | |
| <0.001 | hemangioma of liver | NA | BeFree | Detail | |
| <0.001 | Acute mountain sickness | Two low oxygen sensors, Egl nine homolog 1 (EGLN1) and hypoxia-inducible factor ... | BeFree | 25431923 | Detail |
| 0.001 | Papillary thyroid carcinoma | NA | BeFree | Detail | |
| <0.001 | Anemia, severe | NA | BeFree | Detail | |
| <0.001 | bone destruction | NA | BeFree | Detail | |
| <0.001 | Interstitial fibrosis | NA | BeFree | Detail | |
| 0.001 | Iron deficiency | NA | BeFree | Detail | |
| 0.017 | Hypoxia | NA | GAD | Detail | |
| 0.011 | Malignant neoplasm of lung | Endometral carcinoma is the most common malignant tumor of the female genital tr... | BeFree,GAD | 25556481 | Detail |
| 0.011 | Malignant neoplasm of lung | Erlotinib-cisplatin combination inhibits growth and angiogenesis through c-MYC a... | BeFree,GAD | 25748238 | Detail |
| 0.011 | Malignant neoplasm of lung | In addition, PA-12 blocked the nuclear translocalization of PKM2 in lung cancer ... | BeFree,GAD | 25813626 | Detail |
| <0.001 | age related macular degeneration | HIF1A as a major vascular endothelial growth factor regulator: do its polymorphi... | BeFree | 24995509 | Detail |
| <0.001 | Residual Cancer | NA | BeFree | Detail | |
| 0.003 | Disease Progression | NA | LHGDN | Detail | |
| 0.003 | Hyperoxia | NA | LHGDN | Detail | |
| <0.001 | Malignant neoplasm of male breast | NA | BeFree | Detail | |
| <0.001 | Sepsis | Mechanistically, hypoxia inducible factor-1α (HIF1α) mediated this functional re... | BeFree | 25746953 | Detail |
| <0.001 | Carcinoma, Lewis Lung | NA | BeFree | Detail | |
| <0.001 | Degeneration of lumbar intervertebral disc | NA | BeFree | Detail | |
| <0.001 | Turcot syndrome (disorder) | NA | BeFree | Detail | |
| <0.001 | Acyanotic congenital heart disease | NA | BeFree | Detail | |
| <0.001 | Angiodysplasia of colon | NA | BeFree | Detail | |
| <0.001 | Xeroderma pigmentosum, group A | NA | BeFree | Detail | |
| 0.001 | Impaired glucose tolerance | NA | BeFree | Detail | |
| <0.001 | Qualitative abnormality of granulocyte | NA | BeFree | Detail | |
| <0.001 | Chronic mountain sickness | NA | BeFree | Detail | |
| 0.001 | Carcinoma breast stage IV | NA | BeFree | Detail | |
| <0.001 | Non-small cell lung cancer stage I | Of the 102 stage I NSCLC specimens analyzed, high RBP2 protein expression is clo... | BeFree | 25162518 | Detail |
| <0.001 | gastric adenocarcinoma | NA | BeFree | Detail | |
| <0.001 | Metastatic melanoma | NA | BeFree | Detail | |
| 0.001 | Cancer of Head and Neck | The contribution of glucose transporter (GLUT) and hypoxia-inducible factor-1α (... | BeFree | 25412955 | Detail |
| 0.001 | Cancer of Head and Neck | Nanoparticle delivery of HIF1α siRNA combined with photodynamic therapy as a pot... | BeFree | 25596376 | Detail |
| 0.002 | Liver and Intrahepatic Biliary Tract Carcinoma | The current meta-analysis suggests that the HIF-1α G1790A polymorphism may incre... | BeFree | 25158249 | Detail |
| 0.002 | Liver and Intrahepatic Biliary Tract Carcinoma | Here, we report that the FDA-approved HDACi Vorinostat/SAHA inhibits HIF-1α expr... | BeFree | 25166596 | Detail |
| 0.002 | Liver and Intrahepatic Biliary Tract Carcinoma | Pyruvate kinase M2 affects liver cancer cell behavior through up-regulation of H... | BeFree | 25661370 | Detail |
| 0.002 | Liver and Intrahepatic Biliary Tract Carcinoma | SIRT1 expression was associated with HIF1 protein accumulation in both the NBNC ... | BeFree | 25736100 | Detail |
| 0.122 | Squamous cell carcinoma of esophagus | HIF-1α may modulate VM in ESCC by regulating VE-cadherin expression, which affec... | BeFree,CTD_human | 25548487 | Detail |
| <0.001 | cervical adenocarcinoma | NA | BeFree | Detail | |
| <0.001 | Small cell carcinoma of the cervix | Our results indicate that radiation-induced HIF-1α upregulation was one mechanis... | BeFree | 25408479 | Detail |
| <0.001 | Transitional cell carcinoma of bladder | NA | BeFree | Detail | |
| 0.007 | Conventional (Clear Cell) Renal Cell Carcinoma | Many publications do not support a tumor suppressor role for HIF1α in ccRCC. | BeFree | 24916472 | Detail |
| 0.007 | Conventional (Clear Cell) Renal Cell Carcinoma | Taken together, these results suggest that HIF-1α-dependent inflammation and fib... | BeFree | 25023703 | Detail |
| 0.007 | Conventional (Clear Cell) Renal Cell Carcinoma | Expression and significance of FOXP1, HIF-1a and VEGF in renal clear cell carcin... | BeFree | 25778315 | Detail |
| 0.007 | Conventional (Clear Cell) Renal Cell Carcinoma | Analyses of the transcriptome and metabolome demonstrate that HIF1α mediates alt... | BeFree | 25830305 | Detail |
| 0.009 | Solid tumour | HIF-1α protein is over-expressed in multiple types of human cancer and is the ma... | BeFree | 24804733 | Detail |
| 0.009 | Solid tumour | Hypoxia-inducible factor-1 (HIF-1) is a key heterodimeric transcription factor f... | BeFree | 24916276 | Detail |
| <0.001 | Acute Undifferentiated Leukemia | TRIM62 loss was associated with altered expression of proteins involved in leuke... | BeFree | 25248926 | Detail |
| <0.001 | laryngeal squamous cell carcinoma | NA | BeFree | Detail | |
| 0.001 | Adenocarcinoma of pancreas | NA | BeFree | Detail | |
| <0.001 | Vascular Neoplasms | NA | BeFree | Detail | |
| <0.001 | MYELOMA, ENDOTHELIAL | NA | BeFree | Detail | |
| <0.001 | Chronic ulcer | NA | BeFree | Detail | |
| <0.001 | Nodular melanoma | NA | BeFree | Detail | |
| <0.001 | anaplastic astrocytoma | NA | BeFree | Detail | |
| <0.001 | pilocytic astrocytoma | NA | BeFree | Detail | |
| <0.001 | Adenocarcinoma of colon | The BH3-mimetic obatoclax reduces HIF-1α levels and HIF-1 transcriptional activi... | BeFree | 25979228 | Detail |
| <0.001 | Aortic Aneurysm, Thoracoabdominal | However, little is known about the role of IncRNA HIF 1 alpha-antisense RNA 1 (H... | BeFree | 26062299 | Detail |
| 0.120 | Complications of Diabetes Mellitus | NA | CTD_human | Detail | |
| 0.002 | Malignant neoplasm of liver | The current meta-analysis suggests that the HIF-1α G1790A polymorphism may incre... | BeFree | 25158249 | Detail |
| 0.002 | Malignant neoplasm of liver | Here, we report that the FDA-approved HDACi Vorinostat/SAHA inhibits HIF-1α expr... | BeFree | 25166596 | Detail |
| 0.002 | Malignant neoplasm of liver | Pyruvate kinase M2 affects liver cancer cell behavior through up-regulation of H... | BeFree | 25661370 | Detail |
| 0.002 | Malignant neoplasm of liver | SIRT1 expression was associated with HIF1 protein accumulation in both the NBNC ... | BeFree | 25736100 | Detail |
| <0.001 | intrahepatic cholangiocarcinoma | NA | BeFree | Detail | |
| <0.001 | Multiple fibrofolliculomas | NA | BeFree | Detail | |
| <0.001 | Breast Cancer, Familial | NA | BeFree | Detail | |
| <0.001 | Multiple malignancy | In this study, we reported for the first time that Celastrol could induce HIF-1α... | BeFree | 25383959 | Detail |
| 0.015 | Malignant neoplasm of pancreas | Expression of HIF-1 in pancreatic cancer cells increased under the condition of ... | BeFree | 25119596 | Detail |
| 0.015 | Malignant neoplasm of pancreas | LASP1 is a HIF1α target gene critical for metastasis of pancreatic cancer. | BeFree | 25385028 | Detail |
| 0.015 | Malignant neoplasm of pancreas | Treatment with UBS109, EF31 or curcumin inhibited HSP90, NF-κB, and HIF-1α trans... | BeFree | 25497868 | Detail |
| 0.015 | Malignant neoplasm of pancreas | LB-1 Exerts Antitumor Activity in Pancreatic Cancer by Inhibiting HIF-1α and Sta... | BeFree | 25655308 | Detail |
| 0.015 | Malignant neoplasm of pancreas | Effects of hypoxia-inducible factor-1α silencing on drug resistance of human pan... | BeFree | 25699390 | Detail |
| 0.015 | Malignant neoplasm of pancreas | The effect of lentiviral vector-mediated RNA interference targeting hypoxia-indu... | BeFree | 25853522 | Detail |
| 0.001 | Squamous cell carcinoma of tongue | Effect of HIF-1α on biological activation of human tongue squamous cell carcinom... | BeFree | 25816356 | Detail |
| <0.001 | Trichoepithelioma | We used immunohistochemical staining of formalin-fixed paraffin-embedded BCC (n ... | BeFree | 25181405 | Detail |
| <0.001 | Ischemic cardiomyopathy | Functional analysis of HIF1A target genes revealed that hypoxic and stress respo... | BeFree | 25884818 | Detail |
| <0.001 | Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site | Myeloid HIF-1 is protective in Helicobacter pylori-mediated gastritis. | BeFree | 25710915 | Detail |
| <0.001 | Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site | NA | BeFree | Detail | |
| 0.027 | Malignant neoplasm of prostate | Human selenium binding protein-1 (hSP56) is a negative regulator of HIF-1α and s... | BeFree,GAD | 24874852 | Detail |
| 0.027 | Malignant neoplasm of prostate | HIF1α Regulates mTOR Signaling and Viability of Prostate Cancer Stem Cells. | BeFree,GAD | 25349289 | Detail |
| 0.027 | Malignant neoplasm of prostate | In conclusion, the combination of enzalutamide with HIF-1α inhibition resulted i... | BeFree,GAD | 25829060 | Detail |
| <0.001 | Hashimoto's encephalitis | NA | BeFree | Detail | |
| 0.003 | endometrial carcinoma | Here we show that upregulation of SHARP1 suppressed tumor angiogenesis by decrea... | BeFree | 24918449 | Detail |
| 0.003 | endometrial carcinoma | Our results suggest that the C1772T polymorphism of the HIF-1a may be associated... | BeFree | 25556481 | Detail |
| 0.001 | Secondary malignant neoplasm of liver | NA | BeFree | Detail | |
| 0.002 | Sleep Apnea, Obstructive | NA | GAD | Detail | |
| <0.001 | Bilateral cataracts (disorder) | To identify if HSF4b play it role in cataract development through HIF1α, we tran... | BeFree | 25088997 | Detail |
| <0.001 | Neurodegenerative Disorders | NA | BeFree | Detail | |
| <0.001 | Hepatitis B, Chronic | Association between hypoxia-inducible factor-1α gene polymorphisms and risk of c... | BeFree | 25824382 | Detail |
| 0.003 | Malignant neoplasm of esophagus | NA | BeFree,GAD | Detail | |
| <0.001 | Thyroid carcinoma | Combining adjuvant HIF1α inhibitor chemotherapy with surgery might be an effecti... | BeFree | 25862859 | Detail |
| 0.002 | Malignant glioma | Correlation between ¹⁸F-fluoromisonidazole PET and expression of HIF-1α and VEGF... | BeFree | 24781871 | Detail |
| 0.002 | Malignant glioma | In this study, we investigated the relationship between the expression of p75NTR... | BeFree | 25527128 | Detail |
| <0.001 | primary sclerosing cholangitis | NA | BeFree | Detail | |
| <0.001 | Exercise-induced angina | NA | BeFree | Detail | |
| <0.001 | retroperitoneal sarcoma | NA | BeFree | Detail | |
| <0.001 | Squamous cell carcinoma of mouth | NA | BeFree | Detail | |
| 0.003 | Osteosarcoma of bone | Hypoxia promotes migration and induces CXCR4 expression via HIF-1α activation in... | BeFree | 24618817 | Detail |
| 0.003 | Osteosarcoma of bone | Thus, HIF-1α may be a promising drug target of resveratrol in the context of dev... | BeFree | 25384583 | Detail |
| <0.001 | Carcinoma of larynx | Gene and protein expression of glucose transporter 1 and glucose transporter 3 i... | BeFree | 25412955 | Detail |
| <0.001 | Leukemogenesis | AML1/ETO cooperates with HIF1α to promote leukemogenesis through DNMT3a transact... | BeFree | 25727291 | Detail |
| 0.019 | prostate carcinoma | Human selenium binding protein-1 (hSP56) is a negative regulator of HIF-1α and s... | BeFree | 24874852 | Detail |
| 0.019 | prostate carcinoma | HIF1α Regulates mTOR Signaling and Viability of Prostate Cancer Stem Cells. | BeFree | 25349289 | Detail |
| 0.019 | prostate carcinoma | In conclusion, the combination of enzalutamide with HIF-1α inhibition resulted i... | BeFree | 25829060 | Detail |
| 0.003 | Hot flushes | NA | BeFree,GAD | Detail | |
| <0.001 | toxic shock syndrome | NA | BeFree | Detail | |
| 0.002 | hepatopulmonary syndrome | NA | GAD | Detail | |
| 0.003 | Choroidal Neovascularization | NA | LHGDN | Detail | |
| 0.004 | Epithelial ovarian cancer | In the present study, we found that ROS accumulation in ovarian carcinoma cells ... | BeFree | 25174950 | Detail |
| <0.001 | Refractory cancer | NA | BeFree | Detail | |
| 0.025 | breast carcinoma | Inhibition or upregulation of HIF-1α affects breast cancer cell expression of BC... | BeFree | 24472707 | Detail |
| 0.025 | breast carcinoma | Analysis of the relationship between ultrasound of breast cancer DOT-SDI and the... | BeFree | 24659092 | Detail |
| 0.025 | breast carcinoma | MicroRNA-18a inhibits hypoxia-inducible factor 1α activity and lung metastasis i... | BeFree | 25069832 | Detail |
| 0.025 | breast carcinoma | These results clearly indicated that HIF-1α + COXIV + c-MYC (+ HER2 for HER2+ su... | BeFree | 25270118 | Detail |
| 0.025 | breast carcinoma | HIF-1α decoy oligodeoxynucleotides inhibit HIF-1α signaling and breast cancer pr... | BeFree | 25334080 | Detail |
| 0.025 | breast carcinoma | Hypoxia induced E-cadherin involving regulators of Hippo pathway due to HIF-1α s... | BeFree | 25447306 | Detail |
| 0.025 | breast carcinoma | Increased expression of HIF-1α or HIF target genes in breast cancer biopsies was... | BeFree | 25453096 | Detail |
| 0.025 | breast carcinoma | Associations between C1772T polymorphism in hypoxia-inducible factor-1α gene and... | BeFree | 25484025 | Detail |
| 0.025 | breast carcinoma | This meta-analysis demonstrates that both the C1772T and G1790A polymorphisms in... | BeFree | 25496056 | Detail |
| 0.025 | breast carcinoma | HIF-1α (1772C>T) polymorphism as marker for breast cancer development. | BeFree | 25510668 | Detail |
| 0.025 | breast carcinoma | No association of hypoxia inducible factor-1α gene polymorphisms with breast can... | BeFree | 25520138 | Detail |
| 0.025 | breast carcinoma | Furthermore, we show that up-regulated ΔNp73 levels are associated with increase... | BeFree | 25535357 | Detail |
| 0.025 | breast carcinoma | 4-Hydroxynonenal promotes growth and angiogenesis of breast cancer cells through... | BeFree | 25556440 | Detail |
| 0.025 | breast carcinoma | Human breast cancer database analysis revealed that increased expression (greate... | BeFree | 25587023 | Detail |
| 0.025 | breast carcinoma | Basal and therapy-driven hypoxia-inducible factor-1α confers resistance to endoc... | BeFree | 25929338 | Detail |
| 0.007 | Carcinoma of lung | Endometral carcinoma is the most common malignant tumor of the female genital tr... | BeFree | 25556481 | Detail |
| 0.007 | Carcinoma of lung | Erlotinib-cisplatin combination inhibits growth and angiogenesis through c-MYC a... | BeFree | 25748238 | Detail |
| 0.007 | Carcinoma of lung | In addition, PA-12 blocked the nuclear translocalization of PKM2 in lung cancer ... | BeFree | 25813626 | Detail |
| <0.001 | bacterial sepsis | NA | BeFree | Detail | |
| <0.001 | Malignant neoplasm of gastrointestinal tract | Common polymorphisms in the HIF-1α gene confer susceptibility to digestive cance... | BeFree | 25158249 | Detail |
| 0.005 | Secondary malignant neoplasm of lymph node | TP, EGFR, VEGF, and HIF1α gene expression levels were significantly higher in ly... | BeFree | 24651981 | Detail |
| 0.005 | Secondary malignant neoplasm of lymph node | FOXP1 expression was significantly correlated with the expression of HIF1 and VE... | BeFree | 25778315 | Detail |
| <0.001 | Cancer Relapse | NA | BeFree | Detail | |
| 0.010 | colon carcinoma | The anti-proliferative effect of L-carnosine correlates with a decreased express... | BeFree | 24804733 | Detail |
| 0.010 | colon carcinoma | HIF-1α inhibition reverses multidrug resistance in colon cancer cells via downre... | BeFree | 24901645 | Detail |
| 0.010 | colon carcinoma | Hypoxia-inducible factor-1α and semaphorin4D genes involved with tumor-associate... | BeFree | 25316231 | Detail |
| 0.010 | colon carcinoma | The stable knockdown of HIF-1α or HIF-2α expression induced negative effects on ... | BeFree | 25396735 | Detail |
| 0.010 | colon carcinoma | Colon cancer cell response to the BH3-mimetic was unmodified by HIF-1 activation... | BeFree | 25979228 | Detail |
| 0.012 | stomach carcinoma | Altered expression of hypoxia-inducible factor-1α (HIF-1α) and its regulatory ge... | BeFree | 24927122 | Detail |
| 0.012 | stomach carcinoma | Overexpression of different PFKFB in pancreatic and gastric cancer cells under h... | BeFree | 25320508 | Detail |
| 0.001 | Carcinoma of bladder | In bladder cancer specimens, expression levels of glycolysis-related genes [gluc... | BeFree | 25266796 | Detail |
| 0.005 | Central neuroblastoma | The influence of intermittent hypoxia and HIF-1α siRNA on migration of neuroblas... | BeFree | 25148040 | Detail |
| 0.005 | Central neuroblastoma | Upregulation of HIF-1α by hypoxia protect neuroblastoma cells from apoptosis by ... | BeFree | 25339014 | Detail |
| 0.005 | Central neuroblastoma | Differential regulation of HIF-1α and HIF-2α in neuroblastoma: Estrogen-related ... | BeFree | 25912138 | Detail |
| 0.005 | Malignant neoplasm of kidney | The impact of HIF1α on the Per2 circadian rhythm in renal cancer cell lines. | BeFree,GAD | 25333958 | Detail |
| <0.001 | allergic symptom | HIF-1alpha and vascular endothelial growth factor (VEGF) mRNA and protein expres... | BeFree | 24717944 | Detail |
| <0.001 | Cardiac defects | NA | BeFree | Detail | |
| <0.001 | Cancer of Neck | NA | BeFree | Detail | |
| <0.001 | early pregnancy | NA | BeFree | Detail | |
| <0.001 | Cancer of Digestive System | NA | BeFree | Detail | |
| <0.001 | Hypoxic-Ischemic Encephalopathy | Promotion of HIF-1α and survivin might be a valuable stragegy for therapeutic in... | BeFree | 25339014 | Detail |
| 0.200 | Hypoxia-Ischemia, Brain | NA | BeFree,CTD_human,RGD | Detail | |
| <0.001 | malignant pleural mesothelioma | NA | BeFree | Detail | |
| 0.002 | Invasive breast carcinoma | NA | BeFree | Detail | |
| <0.001 | Post MI | NA | BeFree | Detail | |
| <0.001 | breast adenocarcinoma | NA | BeFree | Detail | |
| <0.001 | latent infection | NA | BeFree | Detail | |
| <0.001 | Cardiomyopathies | NA | BeFree | Detail | |
| <0.001 | Hereditary Papillary Renal Carcinoma | NA | BeFree | Detail | |
| <0.001 | Stromal Neoplasm | NA | BeFree | Detail | |
| <0.001 | Carcinoma, Pancreatic Ductal | NA | BeFree | Detail | |
| 0.001 | Cerebral Ischemia | Mutant hypoxia-inducible factor 1α modified bone marrow mesenchymal stem cells a... | BeFree | 25270619 | Detail |
| 0.009 | ovarian neoplasm | NA | BeFree,LHGDN | Detail | |
| 0.002 | Microsatellite Instability | NA | GAD | Detail | |
| <0.001 | cancer recurrence | NA | BeFree | Detail | |
| <0.001 | Renal ischaemia | NA | BeFree | Detail | |
| <0.001 | myocardial hypoxia | Here we show that myocardial hypoxia actuates fructose metabolism in human and m... | BeFree | 26083752 | Detail |
| <0.001 | Metastatic Prostate Carcinoma | NA | BeFree | Detail | |
| 0.002 | Ischemic stroke | NA | GAD | Detail | |
| <0.001 | Colorectal cancer metastatic | NA | BeFree | Detail | |
| <0.001 | Arthritis, Collagen-Induced | In the joint tissues of mice with collagen-induced arthritis, treatment with ant... | BeFree | 25545169 | Detail |
| 0.080 | Arthritis, Experimental | NA | RGD | Detail | |
| <0.001 | Drug Resistant Epilepsy | HIF-1α may have a regulatory effect on MDR1 expression in refractory epilepsy, w... | BeFree | 24590840 | Detail |
| <0.001 | Invasive Ductal Breast Carcinoma | NA | BeFree | Detail | |
| 0.010 | Malignant neoplasm of ovary | Reactive oxygen species promote ovarian cancer progression via the HIF-1α/LOX/E-... | BeFree,GAD | 25174950 | Detail |
| 0.010 | Malignant neoplasm of ovary | Succinate dehydrogenase subunit B inhibits the AMPK-HIF-1α pathway in human ovar... | BeFree,GAD | 25491408 | Detail |
| 0.010 | Malignant neoplasm of ovary | In this study, we found that the expressions of HIF-1α and HIF-2α were increased... | BeFree,GAD | 25619133 | Detail |
| 0.010 | Malignant neoplasm of ovary | To elucidate the characteristics of this troublesome cancer, we examined HIF-1α ... | BeFree,GAD | 25756515 | Detail |
| <0.001 | endometrial adenocarcinoma | Lastly, we confirmed this IL-6 induction of both STAT3 phosphorylation and HIF1A... | BeFree | 25750101 | Detail |
| 0.004 | Squamous cell carcinoma of the head and neck | NA | BeFree | Detail | |
| 0.120 | Ductal Carcinoma | NA | CTD_human | Detail | |
| 0.003 | sarcoma | Translational Activation of HIF1α by YB-1 Promotes Sarcoma Metastasis. | BeFree | 25965573 | Detail |
| 0.003 | sarcoma | HIF-1 Alpha Regulates the Response of Primary Sarcomas to Radiation Therapy thro... | BeFree | 25973951 | Detail |
| <0.001 | Traditional Serrated Adenoma | NA | BeFree | Detail | |
| <0.001 | chromophobe renal cell carcinoma | NA | BeFree | Detail | |
| <0.001 | Mild cognitive disorder | NA | BeFree | Detail | |
| <0.001 | Inflammatory disorder | NA | BeFree | Detail | |
| <0.001 | Chronic inflammatory disorder | NA | BeFree | Detail | |
| <0.001 | Primary Effusion Lymphoma | NA | BeFree | Detail | |
| <0.001 | Adenoma of large intestine | NA | BeFree | Detail | |
| <0.001 | spindle cell hemangioma | NA | BeFree | Detail | |
| <0.001 | Astrocytoma, low grade | NA | BeFree | Detail | |
| <0.001 | Staphylococcus aureus infection | NA | BeFree | Detail | |
| <0.001 | Adenocarcinoma of large intestine | NA | BeFree | Detail | |
| <0.001 | Hereditary Paraganglioma | NA | BeFree | Detail | |
| <0.001 | Non-Hereditary Clear Cell Renal Cell Carcinoma | NA | BeFree | Detail | |
| 0.002 | pancreatic ductal adenocarcinoma | Overall, our results defined LASP1 as a direct target gene for HIF1α upregulatio... | BeFree | 25385028 | Detail |
| <0.001 | Sporadic Breast Carcinoma | NA | BeFree | Detail | |
| <0.001 | Papillary renal cell carcinoma, sporadic | NA | BeFree | Detail | |
| <0.001 | differentiated thyroid gland carcinoma | NA | BeFree | Detail | |
| <0.001 | Undifferentiated leukemia | TRIM62 loss was associated with altered expression of proteins involved in leuke... | BeFree | 25248926 | Detail |
| 0.005 | renal carcinoma | The impact of HIF1α on the Per2 circadian rhythm in renal cancer cell lines. | BeFree | 25333958 | Detail |
| <0.001 | Cardiac fibrosis | NA | BeFree | Detail | |
| <0.001 | Vascular lesions | NA | BeFree | Detail | |
| <0.001 | Cardiomyopathy, Familial Idiopathic | NA | BeFree | Detail | |
| 0.120 | Micronuclei, Chromosome-Defective | NA | CTD_human | Detail | |
| 0.169 | Mammary Neoplasms | OPN also regulates hypoxia-inducible factor-1α-dependent VEGF expression leading... | BeFree,CTD_human,GAD,LHGDN | 24899149 | Detail |
| 0.169 | Mammary Neoplasms | Analysis of previously published data revealed that higher expression of HIF1A a... | BeFree,CTD_human,GAD,LHGDN | 25069832 | Detail |
| <0.001 | Angiogenic Switch | NA | BeFree | Detail | |
| <0.001 | Hepatocarcinogenesis | NA | BeFree | Detail | |
| <0.001 | Primary Glioblastoma | NA | BeFree | Detail | |
| <0.001 | Malignant Conversion | NA | BeFree | Detail | |
| <0.001 | Salivary Gland Pleomorphic Adenoma | NA | BeFree | Detail | |
| <0.001 | Tumor-Associated Process | Third, MIR210 is regulated by hypoxia inducible factor 1α (HIF-1α), a key transc... | BeFree | 25618442 | Detail |
| 0.019 | Tumor Angiogenesis | Of the 102 stage I NSCLC specimens analyzed, high RBP2 protein expression is clo... | BeFree | 25162518 | Detail |
| 0.019 | Tumor Angiogenesis | Previous studies have shown that Histone Deacetylase Inhibitors (HDACi) block tu... | BeFree | 25166596 | Detail |
| 0.019 | Tumor Angiogenesis | Hypoxia promotes tumor angiogenesis and hypoxia-inducible factor-1 alpha (HIF-1α... | BeFree | 25316231 | Detail |
| 0.019 | Tumor Angiogenesis | Under hypoxic conditions, mARD1(225) autoacetylation inhibited tumor angiogenesi... | BeFree | 25338643 | Detail |
| 0.019 | Tumor Angiogenesis | TAp73 suppresses tumor angiogenesis through repression of proangiogenic cytokine... | BeFree | 25535357 | Detail |
| 0.019 | Tumor Angiogenesis | EGFR is involved in the tumor angiogenesis of HNSCC via the HIF-1α and Notch1 pa... | BeFree | 25723392 | Detail |
| 0.019 | Tumor Angiogenesis | To the best of our knowledge, results of the present study provide the first evi... | BeFree | 25872572 | Detail |
| 0.019 | Tumor Angiogenesis | During tumor progression, hypoxia-inducible factor 1 (HIF-1) plays a critical ro... | BeFree | 26297910 | Detail |
| <0.001 | Tumor Expansion | NA | BeFree | Detail | |
| 0.001 | Tumor Promotion | NA | BeFree | Detail | |
| <0.001 | Xenograft Model | NA | BeFree | Detail | |
| 0.017 | colorectal cancer | Prognostic potential of DNA methylation and transcript levels of HIF1A and EPAS1... | BeFree,GAD | 24825851 | Detail |
| 0.017 | colorectal cancer | Taken together, our data demonstrate for the first time that inhibition of HSP90... | BeFree,GAD | 24861206 | Detail |
| 0.017 | colorectal cancer | Genetic variations in the HIF1A gene modulate response to adjuvant chemotherapy ... | BeFree,GAD | 24969897 | Detail |
| 0.017 | colorectal cancer | This article reviews the central role of HIF1α in CRC angiogenesis, metastasis, ... | BeFree,GAD | 26116902 | Detail |
| 0.017 | colorectal cancer | Herein, an overview of the HIF-1α expression in CRC is presented. | BeFree,GAD | 26214618 | Detail |
| <0.001 | Ductal Breast Carcinoma | To give a translational significance to the study, we took into consideration hu... | BeFree | 25447306 | Detail |
| <0.001 | cancer angiogenesis | NA | BeFree | Detail | |
| 0.080 | Renal Insufficiency | NA | BeFree,RGD | Detail | |
| 0.002 | Glioblastoma multiforme | In cells and tumors that express EGFRvIII, SHP2 also antagonizes the phosphoryla... | BeFree | 24951116 | Detail |
| <0.001 | Cirrhosis | NA | BeFree | Detail | |
| 0.001 | androgen independent prostate cancer | NA | BeFree | Detail | |
| <0.001 | tumor vasculature | NA | BeFree | Detail | |
| <0.001 | Benign Prostatic Hyperplasia | NA | BeFree | Detail | |
| 0.003 | Peripheral Arterial Diseases | In contrast, the minor allele of the HIF1A 1772C>T polymorphism (1772T and 1772T... | BeFree,GAD | 24657063 | Detail |
| <0.001 | Hereditary leiomyomatosis and renal cell cancer | NA | BeFree | Detail | |
| <0.001 | Non-Neoplastic Disorder | The purpose of our study was to characterize LOX, BMP1 and HIF1A expression by r... | BeFree | 25790191 | Detail |
| <0.001 | SPEECH-SOUND DISORDER | SSD treatment inhibited STAT3 activation [phosphorylation of STAT3 (p‑STAT3)], r... | BeFree | 25231214 | Detail |
| <0.001 | ECTRODACTYLY, ECTODERMAL DYSPLASIA, AND CLEFT LIP/PALATE SYNDROME 1 | NA | BeFree | Detail | |
| <0.001 | BREAST CANCER 3 | NA | BeFree | Detail | |
| <0.001 | ABLEPHARON-MACROSTOMIA SYNDROME | Two low oxygen sensors, Egl nine homolog 1 (EGLN1) and hypoxia-inducible factor ... | BeFree | 25431923 | Detail |
| <0.001 | Breast Cancer, Familial Male | NA | BeFree | Detail | |
| <0.001 | PNEUMOTHORAX, PRIMARY SPONTANEOUS | NA | BeFree | Detail | |
| <0.001 | PHOTOPAROXYSMAL RESPONSE 1 | NA | BeFree | Detail | |
| 0.002 | uterine corpus cancer | Here we show that upregulation of SHARP1 suppressed tumor angiogenesis by decrea... | BeFree | 24918449 | Detail |
| 0.002 | uterine corpus cancer | Our results suggest that the C1772T polymorphism of the HIF-1a may be associated... | BeFree | 25556481 | Detail |
| 0.004 | coronary artery disease | NA | BeFree,LHGDN | Detail | |
| <0.001 | Epidermal growth factor receptor negative non-small cell lung cancer | NA | BeFree | Detail | |
| <0.001 | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | NA | BeFree | Detail | |
| <0.001 | Urothelial Carcinoma | NA | BeFree | Detail | |
| 0.118 | liver carcinoma | Recently, we reported that polycomb chromobox 4 (Cbx4) governs the transcription... | BeFree,GAD,LHGDN,RGD | 24916276 | Detail |
| 0.118 | liver carcinoma | Under hypoxic conditions, the mRNA and protein levels of ADM, as well as those o... | BeFree,GAD,LHGDN,RGD | 24927229 | Detail |
| 0.118 | liver carcinoma | Upregulation of BNIP3 mediated by ERK/HIF-1α pathway induces autophagy and contr... | BeFree,GAD,LHGDN,RGD | 25052749 | Detail |
| 0.118 | liver carcinoma | We also summarized the latest findings concerning the role of HIF-1 in the devel... | BeFree,GAD,LHGDN,RGD | 25101278 | Detail |
| 0.118 | liver carcinoma | Taken together, we show that HDAC activity regulates HIF-1α translation, with HD... | BeFree,GAD,LHGDN,RGD | 25166596 | Detail |
| 0.118 | liver carcinoma | Further investigations with a larger sample size may be required to validate the... | BeFree,GAD,LHGDN,RGD | 25195037 | Detail |
| 0.118 | liver carcinoma | Saikosaponin‑d suppresses the expression of cyclooxygenase‑2 through the phospho... | BeFree,GAD,LHGDN,RGD | 25231214 | Detail |
| 0.118 | liver carcinoma | The mechanistic study revealed that ANXA3-mediated maintenance of HCC CSCs/CICs ... | BeFree,GAD,LHGDN,RGD | 25267273 | Detail |
| 0.118 | liver carcinoma | HIF-1α plays a role in the chemotactic migration of hepatocarcinoma cells throug... | BeFree,GAD,LHGDN,RGD | 25323032 | Detail |
| 0.118 | liver carcinoma | Furthermore, miR-338-3p sensitized HCC cells to sorafenib in vitro and in a HCC ... | BeFree,GAD,LHGDN,RGD | 25531114 | Detail |
| 0.118 | liver carcinoma | This study suggests that γ-H2AX is associated with angiogenesis of HCC and γ-H2A... | BeFree,GAD,LHGDN,RGD | 25537504 | Detail |
| 0.118 | liver carcinoma | Our findings that reduced Beclin-1 and high HIF-1α expression are associated wit... | BeFree,GAD,LHGDN,RGD | 25596085 | Detail |
| 0.118 | liver carcinoma | Of the ten miRNAs predicted by the 3'-UTR of HIF-1α mRNA, PPIX treatment increas... | BeFree,GAD,LHGDN,RGD | 25714015 | Detail |
| 0.118 | liver carcinoma | Levels of OPN protein expression were significantly correlated with HIF-1α prote... | BeFree,GAD,LHGDN,RGD | 25749383 | Detail |
| 0.118 | liver carcinoma | Our recent investigations showed that polycomb chromobox 4 (Cbx4) promotes angio... | BeFree,GAD,LHGDN,RGD | 25766328 | Detail |
| 0.118 | liver carcinoma | Thus, NF-κB both positively and negatively fine-tuned HIF-1 in hypoxic hepatocar... | BeFree,GAD,LHGDN,RGD | 25823824 | Detail |
| 0.118 | liver carcinoma | Since chronic hepatitis B (CHB), liver cirrhosis (LC), and HCC are progressive s... | BeFree,GAD,LHGDN,RGD | 25824382 | Detail |
| <0.001 | Allergic rhinitis (disorder) | The role of hypoxia-inducible factor 1α in allergic rhinitis. | BeFree | 24717944 | Detail |
| 0.080 | Acute kidney injury | NA | RGD | Detail | |
| 0.001 | Nasopharyngeal carcinoma | NA | BeFree | Detail | |
| 0.001 | Clear-cell metastatic renal cell carcinoma | NA | BeFree | Detail | |
| 0.001 | limb ischemia | NA | BeFree | Detail | |
| <0.001 | aggressive cancer | NA | BeFree | Detail | |
| 0.002 | Pulmonary arterial hypertension | Furthermore, using a gain and loss of function approach, we showed that increase... | BeFree | 26084306 | Detail |
| <0.001 | Idiopathic pulmonary arterial hypertension | NA | BeFree | Detail | |
| <0.001 | Juvenile arthritis | NA | BeFree | Detail | |
| <0.001 | Discordant ventriculoarterial connection | NA | BeFree | Detail | |
| 0.002 | Triple Negative Breast Neoplasms | Treatment of TNBC cell lines with dutasteride was associated with a dose-depende... | BeFree | 25356777 | Detail |
| <0.001 | Chronic kidney disease due to hypertension | Elevated Endothelial Hypoxia-Inducible Factor-1α Contributes to Glomerular Injur... | BeFree | 25987665 | Detail |
| 0.003 | Infection | NA | LHGDN | Detail | |
| <0.001 | juvenile rheumatoid arthritis | NA | BeFree | Detail | |
| 0.002 | Pulmonary hypertension, primary, 1, with hereditary hemorrhagic telangiectasia | Furthermore, using a gain and loss of function approach, we showed that increase... | BeFree | 26084306 | Detail |
| <0.001 | Experimental Organism Basal Cell Carcinoma | We used immunohistochemical staining of formalin-fixed paraffin-embedded BCC (n ... | BeFree | 25181405 | Detail |
| <0.001 | Tumors in animals | NA | BeFree | Detail | |
| <0.001 | Cytogenetically normal acute myeloid leukemia | NA | BeFree | Detail | |
| <0.001 | Abscess | NA | BeFree | Detail | |
| 0.080 | Acute-Phase Reaction | NA | RGD | Detail | |
| 0.013 | adenocarcinoma | NA | BeFree,LHGDN | Detail | |
| 0.004 | adenoma | NA | BeFree,LHGDN | Detail | |
| <0.001 | Primary myelofibrosis | At baseline (before treatment) cyclo-oxygenase 2 (COX2) was significantly up-reg... | BeFree | 26408680 | Detail |
| 0.120 | Anaplasia | NA | BeFree,CTD_human | Detail | |
| 0.002 | anemia | NA | BeFree | Detail | |
| 0.001 | Anemia, Sickle Cell | Erythropoietin-mediated expression of placenta growth factor is regulated via ac... | BeFree | 25876995 | Detail |
| <0.001 | Angina, Unstable | NA | BeFree | Detail | |
| 0.089 | Anoxia | NA | GAD,LHGDN | Detail | |
| <0.001 | aortic aneurysm | This study identifies polymorphisms in the HIF1A and VEGF genes as potential gen... | BeFree | 24657063 | Detail |
| <0.001 | aortic aneurysm | Long noncoding RNA HIF1A-AS1A reduces apoptosis of vascular smooth muscle cells:... | BeFree | 26062299 | Detail |
| 0.001 | arteriosclerosis | This study identifies polymorphisms in the HIF1A and VEGF genes as potential gen... | BeFree | 24657063 | Detail |
| 0.001 | arteriosclerosis | Our findings identify HIF1α to antagonize APC activation and Th1 T cell polariza... | BeFree | 26404487 | Detail |
| 0.006 | rheumatoid arthritis | This is the first study to provide evidence of a functional link between HIF1α, ... | BeFree,LHGDN | 24525913 | Detail |
| 0.006 | rheumatoid arthritis | HMGB1 induces angiogenesis in rheumatoid arthritis via HIF-1α activation. | BeFree,LHGDN | 25545169 | Detail |
| 0.006 | rheumatoid arthritis | Overexpression of HIF-1α almost completely reversed the suppressive effects of a... | BeFree,LHGDN | 26141990 | Detail |
| 0.080 | Asphyxia | NA | RGD | Detail | |
| <0.001 | asthma | The role of HIF-1alpha in allergic airways has been investigated mainly in bronc... | BeFree | 24717944 | Detail |
| 0.001 | atherosclerosis | This study identifies polymorphisms in the HIF1A and VEGF genes as potential gen... | BeFree | 24657063 | Detail |
| 0.001 | atherosclerosis | Our findings identify HIF1α to antagonize APC activation and Th1 T cell polariza... | BeFree | 26404487 | Detail |
| <0.001 | Bacterial Infections | NA | BeFree | Detail | |
| 0.003 | Barrett esophagus | NA | LHGDN | Detail | |
| <0.001 | Benign Ovarian Neoplasm | NA | BeFree | Detail | |
| 0.001 | Malignant neoplasm of urinary bladder | In bladder cancer specimens, expression levels of glycolysis-related genes [gluc... | BeFree | 25266796 | Detail |
| 0.080 | bladder neck obstruction | NA | RGD | Detail | |
| 0.005 | Bladder Neoplasm | NA | BeFree,GAD,LHGDN | Detail | |
| 0.003 | Bone Diseases | NA | BeFree,LHGDN | Detail | |
| <0.001 | Bone Marrow Diseases | HIF-1α polymorphism in the susceptibility of cervical spondylotic myelopathy and... | BeFree | 25401740 | Detail |
| <0.001 | Bone neoplasms | NA | BeFree | Detail | |
| 0.004 | Brain Neoplasms | We used human glioma tissues and derived brain tumor stem cells (BTSCs) to study... | BeFree,LHGDN | 24366912 | Detail |
| 0.036 | Malignant neoplasm of breast | Inhibition or upregulation of HIF-1α affects breast cancer cell expression of BC... | BeFree,GAD | 24472707 | Detail |
| 0.036 | Malignant neoplasm of breast | Analysis of the relationship between ultrasound of breast cancer DOT-SDI and the... | BeFree,GAD | 24659092 | Detail |
| 0.036 | Malignant neoplasm of breast | MicroRNA-18a inhibits hypoxia-inducible factor 1α activity and lung metastasis i... | BeFree,GAD | 25069832 | Detail |
| 0.036 | Malignant neoplasm of breast | These results clearly indicated that HIF-1α + COXIV + c-MYC (+ HER2 for HER2+ su... | BeFree,GAD | 25270118 | Detail |
| 0.036 | Malignant neoplasm of breast | HIF-1α decoy oligodeoxynucleotides inhibit HIF-1α signaling and breast cancer pr... | BeFree,GAD | 25334080 | Detail |
| 0.036 | Malignant neoplasm of breast | Hypoxia induced E-cadherin involving regulators of Hippo pathway due to HIF-1α s... | BeFree,GAD | 25447306 | Detail |
| 0.036 | Malignant neoplasm of breast | Increased expression of HIF-1α or HIF target genes in breast cancer biopsies was... | BeFree,GAD | 25453096 | Detail |
| 0.036 | Malignant neoplasm of breast | Associations between C1772T polymorphism in hypoxia-inducible factor-1α gene and... | BeFree,GAD | 25484025 | Detail |
| 0.036 | Malignant neoplasm of breast | This meta-analysis demonstrates that both the C1772T and G1790A polymorphisms in... | BeFree,GAD | 25496056 | Detail |
| 0.036 | Malignant neoplasm of breast | HIF-1α (1772C>T) polymorphism as marker for breast cancer development. | BeFree,GAD | 25510668 | Detail |
| 0.036 | Malignant neoplasm of breast | No association of hypoxia inducible factor-1α gene polymorphisms with breast can... | BeFree,GAD | 25520138 | Detail |
| 0.036 | Malignant neoplasm of breast | Furthermore, we show that up-regulated ΔNp73 levels are associated with increase... | BeFree,GAD | 25535357 | Detail |
| 0.036 | Malignant neoplasm of breast | 4-Hydroxynonenal promotes growth and angiogenesis of breast cancer cells through... | BeFree,GAD | 25556440 | Detail |
| 0.036 | Malignant neoplasm of breast | Human breast cancer database analysis revealed that increased expression (greate... | BeFree,GAD | 25587023 | Detail |
| 0.036 | Malignant neoplasm of breast | Basal and therapy-driven hypoxia-inducible factor-1α confers resistance to endoc... | BeFree,GAD | 25929338 | Detail |
| <0.001 | bronchiolitis obliterans | NA | BeFree | Detail | |
| 0.080 | bronchopulmonary dysplasia | NA | RGD | Detail | |
| 0.008 | Malignant tumor of colon | The anti-proliferative effect of L-carnosine correlates with a decreased express... | BeFree | 24804733 | Detail |
| 0.008 | Malignant tumor of colon | HIF-1α inhibition reverses multidrug resistance in colon cancer cells via downre... | BeFree | 24901645 | Detail |
| 0.008 | Malignant tumor of colon | Hypoxia-inducible factor-1α and semaphorin4D genes involved with tumor-associate... | BeFree | 25316231 | Detail |
| 0.008 | Malignant tumor of colon | The stable knockdown of HIF-1α or HIF-2α expression induced negative effects on ... | BeFree | 25396735 | Detail |
| 0.008 | Malignant tumor of colon | Colon cancer cell response to the BH3-mimetic was unmodified by HIF-1 activation... | BeFree | 25979228 | Detail |
| 0.002 | Malignant neoplasm of endometrium | Here we show that upregulation of SHARP1 suppressed tumor angiogenesis by decrea... | BeFree | 24918449 | Detail |
| 0.002 | Malignant neoplasm of endometrium | Our results suggest that the C1772T polymorphism of the HIF-1a may be associated... | BeFree | 25556481 | Detail |
| <0.001 | Malignant neoplasm of larynx | Gene and protein expression of glucose transporter 1 and glucose transporter 3 i... | BeFree | 25412955 | Detail |
| <0.001 | Adenocarcinoma of prostate | NA | BeFree | Detail | |
| 0.002 | Rectal Carcinoma | Expression of VEGF, PlGF and HIF-1α protein was downregulated after NCRT in the ... | BeFree | 25241658 | Detail |
| <0.001 | Malignant neoplasm of thyroid | Combining adjuvant HIF1α inhibitor chemotherapy with surgery might be an effecti... | BeFree | 25862859 | Detail |
| 0.123 | Noninfiltrating Intraductal Carcinoma | NA | BeFree,CTD_human,GAD | Detail | |
| <0.001 | Carcinoma, Ehrlich Tumor | NA | BeFree | Detail | |
| <0.001 | mucinous adenocarcinoma | NA | BeFree | Detail | |
| 0.008 | Non-small cell lung carcinoma | Moreover, HPV-16 oncoproteins promoted HIF-1α protein stability possibly through... | BeFree | 25058399 | Detail |
| 0.008 | Non-small cell lung carcinoma | Retinoblastoma binding protein 2 (RBP2) promotes HIF-1α-VEGF-induced angiogenesi... | BeFree | 25162518 | Detail |
| <0.001 | Carcinoma, Papillary | NA | BeFree | Detail | |
| 0.037 | renal cell carcinoma | The role of HIF1α in renal cell carcinoma tumorigenesis. | BeFree,GAD,LHGDN | 24916472 | Detail |
| 0.037 | renal cell carcinoma | MOTIF analysis of aberrantly hypermethylated regions revealed enrichment for bin... | BeFree,GAD,LHGDN | 24916699 | Detail |
| 0.037 | renal cell carcinoma | In this study, we investigated the effect of SF1126 on hypoxic HIF-1α/HIF-2α sta... | BeFree,GAD,LHGDN | 25578041 | Detail |
Annotation
Annotations
| Descrption | Source | Links |
|---|---|---|
| Regulation of HIF-1 alpha by the proprotein convertases furin and PC7 in human squamous carcinoma ce... | DisGeNET | Detail |
| Our results show the potential use of LCP nanoparticles for efficient delivery of HIF1α siRNA into t... | DisGeNET | Detail |
| Epidermal growth factor receptor inhibition reduces angiogenesis via hypoxia-inducible factor-1α and... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Mutant hypoxia-inducible factor 1α modified bone marrow mesenchymal stem cells ameliorate cerebral i... | DisGeNET | Detail |
| We assessed the difference in transcription activity of two HIF-1alpha polymorphic variants (P582S a... | DisGeNET | Detail |
| Our findings suggest that the HIF-1α A588T polymorphism is significantly associated with higher canc... | DisGeNET | Detail |
| Our findings suggest that the HIF-1α A588T polymorphism is significantly associated with higher canc... | DisGeNET | Detail |
| To understand the role of HIF-1α P582S and A588T genotypes in digestive cancer development, we condu... | DisGeNET | Detail |
| The current findings suggest that HIF1A P582S polymorphism correlates with urinary cancers risk in C... | DisGeNET | Detail |
| HIF-1α P582S and A588T polymorphisms and digestive system cancer risk-a meta-analysis. | DisGeNET | Detail |
| Hypoxia-inducible factor-1 (HIF-1) influences cancer progression and metastasis through various mech... | DisGeNET | Detail |
| The current findings suggest that HIF1A P582S polymorphism correlates with urinary cancers risk in C... | DisGeNET | Detail |
| We aimed to study the prevalence of Hypoxia inducible factor-1α (HIF-1α) P582S and A588T polymorphis... | DisGeNET | Detail |
| In previous studies, the C1772T (P582S) or the G1790A (A588T) polymorphisms of the HIF-1alpha gene h... | DisGeNET | Detail |
| In previous studies, the C1772T (P582S) or the G1790A (A588T) polymorphisms of the HIF-1alpha gene h... | DisGeNET | Detail |
| Hypoxia-inducible factor-1 (HIF-1) influences cancer progression and metastasis through various mech... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| The effects of hypoxia and hypoxia-inducible factor-1α (HIF-1α) transfection and silencing with siRN... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Prognostic potential of DNA methylation and transcript levels of HIF1A and EPAS1 in colorectal cance... | DisGeNET | Detail |
| Taken together, our data demonstrate for the first time that inhibition of HSP90 downregulates both ... | DisGeNET | Detail |
| Genetic variations in the HIF1A gene modulate response to adjuvant chemotherapy after surgery in pat... | DisGeNET | Detail |
| This article reviews the central role of HIF1α in CRC angiogenesis, metastasis, and progression as w... | DisGeNET | Detail |
| HIF-1α in colorectal carcinoma: review of the literature. | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| The data indicate that the overexpression of survivin in AdCC is related to HIF-1α, TGF-β1 and TFE3. | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| The purpose of this study is to investigate the expression of succinate dehydrogenase (SDH)A, SDHB, ... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| We studied the effect of pre-eclampsia sera on the expression of placenta growth factor (PlGF), solu... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| This aberrant activation of pSTAT3 and HIF1A is confirmed by sequential analysis of eutopic endometr... | DisGeNET | Detail |
| We aimed to investigate the expression of HIF-1α and MDR1/P-glycoprotein in refractory epilepsy, to ... | DisGeNET | Detail |
| These results demonstrated the overexpression of HIF-1α and MDR1/Pgp in hippocampus and MTL/entorhin... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Myeloid HIF-1 is protective in Helicobacter pylori-mediated gastritis. | DisGeNET | Detail |
| Treating glioblastoma with siRNA targeting HIF-1α in vivo can significantly reduce tumor growth and ... | DisGeNET | Detail |
| Given the role of HIF-1α in cell migration, we conclude that the attenuation of HIF-1α-dependent gli... | DisGeNET | Detail |
| Hypoxia enhances migration and invasion in glioblastoma by promoting a mesenchymal shift mediated by... | DisGeNET | Detail |
| Targeting Hypoxia-Inducible Factor 1α in a New Orthotopic Model of Glioblastoma Recapitulating the H... | DisGeNET | Detail |
| We used human glioma tissues and derived brain tumor stem cells (BTSCs) to study the expression of H... | DisGeNET | Detail |
| The IRS of HIF-1α in the tumour did not correlate with the SUVtumour of FMISO in either newly diagno... | DisGeNET | Detail |
| Silencing of HIF-1α enhances the radiation sensitivity of human glioma growth in vitro and in vivo. | DisGeNET | Detail |
| HIF-1α genetic variants and protein expression confer the susceptibility and prognosis of gliomas. | DisGeNET | Detail |
| miR-184 and HIF-1α protein levels were significantly upregulated in human glioma cells. | DisGeNET | Detail |
| RNA interference targeting hypoxia-inducible factor 1α via a novel multifunctional surfactant attenu... | DisGeNET | Detail |
| Given the role of HIF-1α in cell migration, we conclude that the attenuation of HIF-1α-dependent gli... | DisGeNET | Detail |
| The HIF-1α-p75NTR-EMT axis may play a central role in glioma tumorigenesis. | DisGeNET | Detail |
| Hypoxia-inducible factor 1α (HIF-1α) activity is one of the major players in hypoxia-mediated glioma... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
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| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Moreover, the protein levels of VEGF, phosphorylated STAT3, total STAT3 and Bcl-2 were significantly... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Two polymorphisms in the HIF-1a gene (rs11549465 and rs115494657>rs115494657) were examined in 157 h... | DisGeNET | Detail |
| Association between hypoxia-inducible factor-1α gene polymorphisms and risk of chronic hepatitis B a... | DisGeNET | Detail |
| We performed immunohistochemical studies on 23 hemangioblastomas, 13 meningiomas and 4 hemangioperic... | DisGeNET | Detail |
| Low oxygen tension or von Hippel-Lindau (Vhl) tumor suppressor loss is known to stabilize hypoxia-in... | DisGeNET | Detail |
| In normoxia, knockdown of JMJD6 in JEG3 cells stabilized HIF1A with a concomitant decrease in von Hi... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Dysregulation of HIF-1- and HIF-2-mediated transcription leads to imbalance of pro-oxidant and anti-... | DisGeNET | Detail |
| Accumulation of hypoxia inducible factor-1α (HIF-1α) is commonly an acute and beneficial response to... | DisGeNET | Detail |
| Hypoxia- or PDGF-BB-dependent paxillin tyrosine phosphorylation in pulmonary hypertension is reverse... | DisGeNET | Detail |
| We revealed that overexpression of HEXIM1 prevented hypoxia-induced expression of HIF-1α protein and... | DisGeNET | Detail |
| These observations suggest that altered glucose metabolism and G6PD overactivation play a key role i... | DisGeNET | Detail |
| We also demonstrated that Pyk2 plays a crucial role in ROS generation during hypoxic stress and that... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| To give a translational significance to the study, we took into consideration human pair-matched duc... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| In present study, we determined the promotion of HIF-1α and survivin in brain samples of a mouse mod... | DisGeNET | Detail |
| In conclusion, the present findings demonstrate that the hypoxia/HIF-1α microenvironment provides a ... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| In a rat model of chronic renal failure, the known increase in hepatic OSTα expression was associate... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Modulation of mRNA expression of several hypoxia-related genes was also observed after hypoxic expos... | DisGeNET | Detail |
| Thus high HIF1α expression serves as a reliable marker, which identifies patients with a poor progno... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| In gene expression analysis, low oxygen levels promoted HIF1A activation in a time-dependent manner,... | DisGeNET | Detail |
| Thus high HIF1α expression serves as a reliable marker, which identifies patients with a poor progno... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Association between hypoxia-inducible factor-1α gene polymorphisms and risk of chronic hepatitis B a... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Of the ten miRNAs predicted by the 3'-UTR of HIF-1α mRNA, PPIX treatment increased miR-199a-5p, lead... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| And this is the first time the HIF1A polymorphisms in COPD in a Chinese population has been reported... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| HIF-1α and Sema4D expression are closely related to lymphatic metastasis, specific histological type... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Altered expression of hypoxia-inducible factor-1α (HIF-1α) and its regulatory genes in gastric cance... | DisGeNET | Detail |
| Overexpression of different PFKFB in pancreatic and gastric cancer cells under hypoxic condition is ... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
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| In addition, the combination of VEGF siRNA and everolimus significantly reversed P-glycoprotein expr... | DisGeNET | Detail |
| Rosiglitazone suppresses angiogenesis in multiple myeloma via downregulation of hypoxia-inducible fa... | DisGeNET | Detail |
| We show the unprecedented role of the metabolic phenotype in inducing drug resistance through LDHA a... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Additionally, this work supports the strategy of exploring HIF1α as a therapeutic target in specific... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Furthermore, coexpression of HIF-1α and CXCR4 was significantly higher in patients with distant meta... | DisGeNET | Detail |
| TNCL increased the expression of several oncogenes, including MMP9, anaplastic lymphoma kinase (ALK)... | DisGeNET | Detail |
| Epithelial to mesenchymal transition (EMT), invasion, and motility are essential steps in colorectal... | DisGeNET | Detail |
| Hypoxia-inducible factor 1α (HIF-1α) plays an important role in regulating cell survival and angioge... | DisGeNET | Detail |
| The results of this study reveal a novel role for miR-18a in targeting HIF1A and repressing metastas... | DisGeNET | Detail |
| Tumor microenvironmental hypoxia induces hypoxia inducible factor-1α (HIF-1α) overexpression, leadin... | DisGeNET | Detail |
| HIF-1α promotes HCC progression and metastasis by upregulating CXCL6 transcription in HCC cells, pro... | DisGeNET | Detail |
| They function differently in different cancers with specific mechanisms. p53 and HIF-1α appear to be... | DisGeNET | Detail |
| LASP1 is a HIF1α target gene critical for metastasis of pancreatic cancer. | DisGeNET | Detail |
| HIF-1α mediates hypoxia-induced expression of the chemokine receptor CXCR4 and contributes to metast... | DisGeNET | Detail |
| We highlighted the importance of nuclear HIF-1α in the biology of metastasis for the mesenchymal-epi... | DisGeNET | Detail |
| Intratumoral hypoxia followed by stabilization/activation of hypoxia-inducible factor 1 (HIF-1) and ... | DisGeNET | Detail |
| In this study, we investigated the relationship between the expression of p75NTR in malignant glioma... | DisGeNET | Detail |
| Hypoxia inducible factor-1 alpha (HIF-1α) plays an important role in angiogenesis and metastasis and... | DisGeNET | Detail |
| Our recent investigations showed that polycomb chromobox 4 (Cbx4) promotes angiogenesis and metastas... | DisGeNET | Detail |
| Functional studies showed IL-24 inhibited tumor cell migration and invasion concomitant with reducti... | DisGeNET | Detail |
| The expression of the transcription factor, hypoxia-inducible factor-1α (HIF-1α), is mainly induced ... | DisGeNET | Detail |
| HIF-1α drives miR-210's overexpression and the resultant alteration of cellular processes, including... | DisGeNET | Detail |
| This leads to HIF1α-mediated sarcoma cell invasion and enhanced metastatic capacity in vivo, highlig... | DisGeNET | Detail |
| Hypoxia inducible factor-1α: Its role in colorectal carcinogenesis and metastasis. | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| The influence of intermittent hypoxia and HIF-1α siRNA on migration of neuroblastoma cells and in vi... | DisGeNET | Detail |
| Upregulation of HIF-1α by hypoxia protect neuroblastoma cells from apoptosis by promoting survivin e... | DisGeNET | Detail |
| Differential regulation of HIF-1α and HIF-2α in neuroblastoma: Estrogen-related receptor alpha (ERRα... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Hypoxia promotes migration and induces CXCR4 expression via HIF-1α activation in human osteosarcoma. | DisGeNET | Detail |
| Thus, HIF-1α may be a promising drug target of resveratrol in the context of development of anticanc... | DisGeNET | Detail |
| Reactive oxygen species promote ovarian cancer progression via the HIF-1α/LOX/E-cadherin pathway. | DisGeNET | Detail |
| Succinate dehydrogenase subunit B inhibits the AMPK-HIF-1α pathway in human ovarian cancer in vitro. | DisGeNET | Detail |
| In this study, we found that the expressions of HIF-1α and HIF-2α were increased under hypoxia in se... | DisGeNET | Detail |
| To elucidate the characteristics of this troublesome cancer, we examined HIF-1α expression under nor... | DisGeNET | Detail |
| The aim of study was to discuss the correlation and regulatory mechanism of HIF-1 and miR-191 expres... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Taken together, our data demonstrate that HIF-1α acts downstream of TNF-α to inhibit VASP expression... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
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| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| A well-characterized murine model of prostate cancer was used to investigate the regulation of hypox... | DisGeNET | Detail |
| KLF5 loss enhances tumor angiogenesis by attenuating PI3K/AKT signaling and subsequent accumulation ... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Overexpression of angiogenic factors (activation of VEGF through HIF-1A) may predispose to chronic c... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Beta-lapachone inhibits pathological retinal neovascularization in oxygen-induced retinopathy via re... | DisGeNET | Detail |
| Inhibition of hypoxia inducible factor 1α by siRNA-induced apoptosis in human retinoblastoma cells. | DisGeNET | Detail |
| To the best of our knowledge, results of the present study provide the first evidence that miR-181b ... | DisGeNET | Detail |
| Thus, strategies blocking HIF-1α in the developing eye in the pathological hypoxia could serve as a ... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| These findings were in line with previous data on the role of HIF-1A/VEGF/ING-4 axis in the pathogen... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Effect of HSF4b on age related cataract may through its novel downstream target Hif1α. | DisGeNET | Detail |
| Mechanistically, hypoxia inducible factor-1α (HIF1α) mediated this functional re-programming of mono... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| HIF-1α polymorphism in the susceptibility of cervical spondylotic myelopathy and its outcome after a... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Collectively, these results demonstrate that NCX1 expression is regulated by the Sp3/REST/HDAC1/HDAC... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
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| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| To identify if HSF4b play it role in cataract development through HIF1α, we transfected SRA01/04 len... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| SOCS3 blocks HIF-1α expression to inhibit proliferation and angiogenesis of human small cell lung ca... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Genetic studies coupled with reverse transcription polymerase chain reaction profiling revealed that... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| HIF-1α induces VE-cadherin expression and modulates vasculogenic mimicry in esophageal carcinoma cel... | DisGeNET | Detail |
| Furthermore, using a gain and loss of function approach, we showed that increased hypoxia-inducible ... | DisGeNET | Detail |
| Cobalt chloride (CoCl2), a HIF-1α activator, attenuated the IK-induced growth-inhibiting and apoptos... | DisGeNET | Detail |
| This meta-analysis demonstrates that both the C1772T and G1790A polymorphisms in the HIF-1α gene lik... | DisGeNET | Detail |
| In this study, we have investigated the role of HIF-1α in the pathobilogy of GBC and effect of hispi... | DisGeNET | Detail |
| MicroRNA-18a inhibits hypoxia-inducible factor 1α activity and lung metastasis in basal breast cance... | DisGeNET | Detail |
| Hypoxia induced E-cadherin involving regulators of Hippo pathway due to HIF-1α stabilization/nuclear... | DisGeNET | Detail |
| Finally, significantly less Tip110, p53, and HIF-1α was detected in the hypoxic region of bone metas... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Recently, proangiogenic factors hypoxia-inducible factor-1 alpha (HIF-1α) and vascular endothelial g... | DisGeNET | Detail |
| In this study, the functional variants in genes involved in the hypoxia signaling pathway, hypoxia-i... | DisGeNET | Detail |
| BRG1 is overexpressed in the aortic media of thoracic aortic aneurysms and the interaction between B... | DisGeNET | Detail |
| Cellular adaptation to a hypoxic microenvironment is essential for tumor progression and is largely ... | DisGeNET | Detail |
| Increased expression of HIF-1α has also been demonstrated to be involved in tumor progression. | DisGeNET | Detail |
| As one of the major mediators of hypoxic response, hypoxia inducible factor-1 (HIF-1) has been shown... | DisGeNET | Detail |
| HIF-1-mediated suppression of acyl-CoA dehydrogenases and fatty acid oxidation is critical for cance... | DisGeNET | Detail |
| Resveratrol inhibits hypoxia-inducible factor-1α-mediated androgen receptor signaling and represses ... | DisGeNET | Detail |
| This review delineates the crucial role that HIF-1α plays in carcinogenesis, tumor angiogenesis and ... | DisGeNET | Detail |
| Cinnamic aldehyde suppresses hypoxia-induced angiogenesis via inhibition of hypoxia-inducible factor... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Expression of HIF-1 regulated proteins vascular endothelial growth factor, carbonic anhydrase IX and... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| We found expression of hypoxia-inducible factor 1α (HIF-1α) protein in well-vascularized tumor regio... | DisGeNET | Detail |
| Cobalt chloride (CoCl2), a HIF-1α activator, attenuated the IK-induced growth-inhibiting and apoptos... | DisGeNET | Detail |
| This meta-analysis demonstrates that both the C1772T and G1790A polymorphisms in the HIF-1α gene lik... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| In this study, we have investigated the role of HIF-1α in the pathobilogy of GBC and effect of hispi... | DisGeNET | Detail |
| Expression of HIF-1 in pancreatic cancer cells increased under the condition of chronic hypoxia, whi... | DisGeNET | Detail |
| LASP1 is a HIF1α target gene critical for metastasis of pancreatic cancer. | DisGeNET | Detail |
| Treatment with UBS109, EF31 or curcumin inhibited HSP90, NF-κB, and HIF-1α transcription in PC cell ... | DisGeNET | Detail |
| LB-1 Exerts Antitumor Activity in Pancreatic Cancer by Inhibiting HIF-1α and Stat3 Signaling. | DisGeNET | Detail |
| Effects of hypoxia-inducible factor-1α silencing on drug resistance of human pancreatic cancer cell ... | DisGeNET | Detail |
| The effect of lentiviral vector-mediated RNA interference targeting hypoxia-inducible factor 1α on t... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Two low oxygen sensors, Egl nine homolog 1 (EGLN1) and hypoxia-inducible factor 1-α inhibitor (HIF-1... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Endometral carcinoma is the most common malignant tumor of the female genital tract and the fourth m... | DisGeNET | Detail |
| Erlotinib-cisplatin combination inhibits growth and angiogenesis through c-MYC and HIF-1α in EGFR-mu... | DisGeNET | Detail |
| In addition, PA-12 blocked the nuclear translocalization of PKM2 in lung cancer cells, resulting in ... | DisGeNET | Detail |
| HIF1A as a major vascular endothelial growth factor regulator: do its polymorphisms have an associat... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Mechanistically, hypoxia inducible factor-1α (HIF1α) mediated this functional re-programming of mono... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Of the 102 stage I NSCLC specimens analyzed, high RBP2 protein expression is closely associated with... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| The contribution of glucose transporter (GLUT) and hypoxia-inducible factor-1α (HIF-1α) activity to ... | DisGeNET | Detail |
| Nanoparticle delivery of HIF1α siRNA combined with photodynamic therapy as a potential treatment str... | DisGeNET | Detail |
| The current meta-analysis suggests that the HIF-1α G1790A polymorphism may increase the risk of colo... | DisGeNET | Detail |
| Here, we report that the FDA-approved HDACi Vorinostat/SAHA inhibits HIF-1α expression in liver canc... | DisGeNET | Detail |
| Pyruvate kinase M2 affects liver cancer cell behavior through up-regulation of HIF-1α and Bcl-xL in ... | DisGeNET | Detail |
| SIRT1 expression was associated with HIF1 protein accumulation in both the NBNC liver and liver canc... | DisGeNET | Detail |
| HIF-1α may modulate VM in ESCC by regulating VE-cadherin expression, which affects VM formation thro... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Our results indicate that radiation-induced HIF-1α upregulation was one mechanism of radioresistance... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Many publications do not support a tumor suppressor role for HIF1α in ccRCC. | DisGeNET | Detail |
| Taken together, these results suggest that HIF-1α-dependent inflammation and fibrosis may be an earl... | DisGeNET | Detail |
| Expression and significance of FOXP1, HIF-1a and VEGF in renal clear cell carcinoma. | DisGeNET | Detail |
| Analyses of the transcriptome and metabolome demonstrate that HIF1α mediates altered tumor metabolis... | DisGeNET | Detail |
| HIF-1α protein is over-expressed in multiple types of human cancer and is the major cause of resista... | DisGeNET | Detail |
| Hypoxia-inducible factor-1 (HIF-1) is a key heterodimeric transcription factor for the cellular adap... | DisGeNET | Detail |
| TRIM62 loss was associated with altered expression of proteins involved in leukemia stem cell homeos... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| The BH3-mimetic obatoclax reduces HIF-1α levels and HIF-1 transcriptional activity and sensitizes hy... | DisGeNET | Detail |
| However, little is known about the role of IncRNA HIF 1 alpha-antisense RNA 1 (HIF1a-AS1) in regulat... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| The current meta-analysis suggests that the HIF-1α G1790A polymorphism may increase the risk of colo... | DisGeNET | Detail |
| Here, we report that the FDA-approved HDACi Vorinostat/SAHA inhibits HIF-1α expression in liver canc... | DisGeNET | Detail |
| Pyruvate kinase M2 affects liver cancer cell behavior through up-regulation of HIF-1α and Bcl-xL in ... | DisGeNET | Detail |
| SIRT1 expression was associated with HIF1 protein accumulation in both the NBNC liver and liver canc... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| In this study, we reported for the first time that Celastrol could induce HIF-1α protein accumulatio... | DisGeNET | Detail |
| Expression of HIF-1 in pancreatic cancer cells increased under the condition of chronic hypoxia, whi... | DisGeNET | Detail |
| LASP1 is a HIF1α target gene critical for metastasis of pancreatic cancer. | DisGeNET | Detail |
| Treatment with UBS109, EF31 or curcumin inhibited HSP90, NF-κB, and HIF-1α transcription in PC cell ... | DisGeNET | Detail |
| LB-1 Exerts Antitumor Activity in Pancreatic Cancer by Inhibiting HIF-1α and Stat3 Signaling. | DisGeNET | Detail |
| Effects of hypoxia-inducible factor-1α silencing on drug resistance of human pancreatic cancer cell ... | DisGeNET | Detail |
| The effect of lentiviral vector-mediated RNA interference targeting hypoxia-inducible factor 1α on t... | DisGeNET | Detail |
| Effect of HIF-1α on biological activation of human tongue squamous cell carcinoma SCC-15 cells in vi... | DisGeNET | Detail |
| We used immunohistochemical staining of formalin-fixed paraffin-embedded BCC (n = 45) and TE (n = 35... | DisGeNET | Detail |
| Functional analysis of HIF1A target genes revealed that hypoxic and stress response genes are activa... | DisGeNET | Detail |
| Myeloid HIF-1 is protective in Helicobacter pylori-mediated gastritis. | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Human selenium binding protein-1 (hSP56) is a negative regulator of HIF-1α and suppresses the malign... | DisGeNET | Detail |
| HIF1α Regulates mTOR Signaling and Viability of Prostate Cancer Stem Cells. | DisGeNET | Detail |
| In conclusion, the combination of enzalutamide with HIF-1α inhibition resulted in synergistic inhibi... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Here we show that upregulation of SHARP1 suppressed tumor angiogenesis by decreasing hypoxia-inducib... | DisGeNET | Detail |
| Our results suggest that the C1772T polymorphism of the HIF-1a may be associated with endometrial ca... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| To identify if HSF4b play it role in cataract development through HIF1α, we transfected SRA01/04 len... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Association between hypoxia-inducible factor-1α gene polymorphisms and risk of chronic hepatitis B a... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Combining adjuvant HIF1α inhibitor chemotherapy with surgery might be an effective therapeutic strat... | DisGeNET | Detail |
| Correlation between ¹⁸F-fluoromisonidazole PET and expression of HIF-1α and VEGF in newly diagnosed ... | DisGeNET | Detail |
| In this study, we investigated the relationship between the expression of p75NTR in malignant glioma... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Hypoxia promotes migration and induces CXCR4 expression via HIF-1α activation in human osteosarcoma. | DisGeNET | Detail |
| Thus, HIF-1α may be a promising drug target of resveratrol in the context of development of anticanc... | DisGeNET | Detail |
| Gene and protein expression of glucose transporter 1 and glucose transporter 3 in human laryngeal ca... | DisGeNET | Detail |
| AML1/ETO cooperates with HIF1α to promote leukemogenesis through DNMT3a transactivation. | DisGeNET | Detail |
| Human selenium binding protein-1 (hSP56) is a negative regulator of HIF-1α and suppresses the malign... | DisGeNET | Detail |
| HIF1α Regulates mTOR Signaling and Viability of Prostate Cancer Stem Cells. | DisGeNET | Detail |
| In conclusion, the combination of enzalutamide with HIF-1α inhibition resulted in synergistic inhibi... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| In the present study, we found that ROS accumulation in ovarian carcinoma cells upregulated HIF-1α e... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Inhibition or upregulation of HIF-1α affects breast cancer cell expression of BCRP; AI responsivenes... | DisGeNET | Detail |
| Analysis of the relationship between ultrasound of breast cancer DOT-SDI and the expression of MVD, ... | DisGeNET | Detail |
| MicroRNA-18a inhibits hypoxia-inducible factor 1α activity and lung metastasis in basal breast cance... | DisGeNET | Detail |
| These results clearly indicated that HIF-1α + COXIV + c-MYC (+ HER2 for HER2+ subtype) may be useful... | DisGeNET | Detail |
| HIF-1α decoy oligodeoxynucleotides inhibit HIF-1α signaling and breast cancer proliferation. | DisGeNET | Detail |
| Hypoxia induced E-cadherin involving regulators of Hippo pathway due to HIF-1α stabilization/nuclear... | DisGeNET | Detail |
| Increased expression of HIF-1α or HIF target genes in breast cancer biopsies was associated with dec... | DisGeNET | Detail |
| Associations between C1772T polymorphism in hypoxia-inducible factor-1α gene and breast cancer: a me... | DisGeNET | Detail |
| This meta-analysis demonstrates that both the C1772T and G1790A polymorphisms in the HIF-1α gene lik... | DisGeNET | Detail |
| HIF-1α (1772C>T) polymorphism as marker for breast cancer development. | DisGeNET | Detail |
| No association of hypoxia inducible factor-1α gene polymorphisms with breast cancer in North-West In... | DisGeNET | Detail |
| Furthermore, we show that up-regulated ΔNp73 levels are associated with increased angiogenesis in hu... | DisGeNET | Detail |
| 4-Hydroxynonenal promotes growth and angiogenesis of breast cancer cells through HIF-1α stabilizatio... | DisGeNET | Detail |
| Human breast cancer database analysis revealed that increased expression (greater than the median) o... | DisGeNET | Detail |
| Basal and therapy-driven hypoxia-inducible factor-1α confers resistance to endocrine therapy in estr... | DisGeNET | Detail |
| Endometral carcinoma is the most common malignant tumor of the female genital tract and the fourth m... | DisGeNET | Detail |
| Erlotinib-cisplatin combination inhibits growth and angiogenesis through c-MYC and HIF-1α in EGFR-mu... | DisGeNET | Detail |
| In addition, PA-12 blocked the nuclear translocalization of PKM2 in lung cancer cells, resulting in ... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Common polymorphisms in the HIF-1α gene confer susceptibility to digestive cancer: a meta-analysis. | DisGeNET | Detail |
| TP, EGFR, VEGF, and HIF1α gene expression levels were significantly higher in lymph node metastases ... | DisGeNET | Detail |
| FOXP1 expression was significantly correlated with the expression of HIF1 and VEGF (r=0.54, p<0.01 a... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| The anti-proliferative effect of L-carnosine correlates with a decreased expression of hypoxia induc... | DisGeNET | Detail |
| HIF-1α inhibition reverses multidrug resistance in colon cancer cells via downregulation of MDR1/P-g... | DisGeNET | Detail |
| Hypoxia-inducible factor-1α and semaphorin4D genes involved with tumor-associated macrophage-induced... | DisGeNET | Detail |
| The stable knockdown of HIF-1α or HIF-2α expression induced negative effects on the malignant phenot... | DisGeNET | Detail |
| Colon cancer cell response to the BH3-mimetic was unmodified by HIF-1 activation and OBX induced a d... | DisGeNET | Detail |
| Altered expression of hypoxia-inducible factor-1α (HIF-1α) and its regulatory genes in gastric cance... | DisGeNET | Detail |
| Overexpression of different PFKFB in pancreatic and gastric cancer cells under hypoxic condition is ... | DisGeNET | Detail |
| In bladder cancer specimens, expression levels of glycolysis-related genes [glucose transporter (GLU... | DisGeNET | Detail |
| The influence of intermittent hypoxia and HIF-1α siRNA on migration of neuroblastoma cells and in vi... | DisGeNET | Detail |
| Upregulation of HIF-1α by hypoxia protect neuroblastoma cells from apoptosis by promoting survivin e... | DisGeNET | Detail |
| Differential regulation of HIF-1α and HIF-2α in neuroblastoma: Estrogen-related receptor alpha (ERRα... | DisGeNET | Detail |
| The impact of HIF1α on the Per2 circadian rhythm in renal cancer cell lines. | DisGeNET | Detail |
| HIF-1alpha and vascular endothelial growth factor (VEGF) mRNA and protein expression were also evalu... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Promotion of HIF-1α and survivin might be a valuable stragegy for therapeutic intervention for hypox... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Mutant hypoxia-inducible factor 1α modified bone marrow mesenchymal stem cells ameliorate cerebral i... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Here we show that myocardial hypoxia actuates fructose metabolism in human and mouse models of patho... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| In the joint tissues of mice with collagen-induced arthritis, treatment with anti-HMGB1 neutralizing... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| HIF-1α may have a regulatory effect on MDR1 expression in refractory epilepsy, which is probably con... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Reactive oxygen species promote ovarian cancer progression via the HIF-1α/LOX/E-cadherin pathway. | DisGeNET | Detail |
| Succinate dehydrogenase subunit B inhibits the AMPK-HIF-1α pathway in human ovarian cancer in vitro. | DisGeNET | Detail |
| In this study, we found that the expressions of HIF-1α and HIF-2α were increased under hypoxia in se... | DisGeNET | Detail |
| To elucidate the characteristics of this troublesome cancer, we examined HIF-1α expression under nor... | DisGeNET | Detail |
| Lastly, we confirmed this IL-6 induction of both STAT3 phosphorylation and HIF1A mRNA expression in ... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Translational Activation of HIF1α by YB-1 Promotes Sarcoma Metastasis. | DisGeNET | Detail |
| HIF-1 Alpha Regulates the Response of Primary Sarcomas to Radiation Therapy through a Cell Autonomou... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Overall, our results defined LASP1 as a direct target gene for HIF1α upregulation that is critical f... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| TRIM62 loss was associated with altered expression of proteins involved in leukemia stem cell homeos... | DisGeNET | Detail |
| The impact of HIF1α on the Per2 circadian rhythm in renal cancer cell lines. | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| OPN also regulates hypoxia-inducible factor-1α-dependent VEGF expression leading to breast tumor gro... | DisGeNET | Detail |
| Analysis of previously published data revealed that higher expression of HIF1A and a panel of hypoxi... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Third, MIR210 is regulated by hypoxia inducible factor 1α (HIF-1α), a key transcription factor media... | DisGeNET | Detail |
| Of the 102 stage I NSCLC specimens analyzed, high RBP2 protein expression is closely associated with... | DisGeNET | Detail |
| Previous studies have shown that Histone Deacetylase Inhibitors (HDACi) block tumor angiogenesis thr... | DisGeNET | Detail |
| Hypoxia promotes tumor angiogenesis and hypoxia-inducible factor-1 alpha (HIF-1α) plays a pivotal ro... | DisGeNET | Detail |
| Under hypoxic conditions, mARD1(225) autoacetylation inhibited tumor angiogenesis by decreasing the ... | DisGeNET | Detail |
| TAp73 suppresses tumor angiogenesis through repression of proangiogenic cytokines and HIF-1α activit... | DisGeNET | Detail |
| EGFR is involved in the tumor angiogenesis of HNSCC via the HIF-1α and Notch1 pathways. | DisGeNET | Detail |
| To the best of our knowledge, results of the present study provide the first evidence that miR-181b ... | DisGeNET | Detail |
| During tumor progression, hypoxia-inducible factor 1 (HIF-1) plays a critical role in tumor angiogen... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Prognostic potential of DNA methylation and transcript levels of HIF1A and EPAS1 in colorectal cance... | DisGeNET | Detail |
| Taken together, our data demonstrate for the first time that inhibition of HSP90 downregulates both ... | DisGeNET | Detail |
| Genetic variations in the HIF1A gene modulate response to adjuvant chemotherapy after surgery in pat... | DisGeNET | Detail |
| This article reviews the central role of HIF1α in CRC angiogenesis, metastasis, and progression as w... | DisGeNET | Detail |
| Herein, an overview of the HIF-1α expression in CRC is presented. | DisGeNET | Detail |
| To give a translational significance to the study, we took into consideration human pair-matched duc... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| In cells and tumors that express EGFRvIII, SHP2 also antagonizes the phosphorylation of EGFRvIII and... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| In contrast, the minor allele of the HIF1A 1772C>T polymorphism (1772T and 1772T-1790G haplotype) wa... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| The purpose of our study was to characterize LOX, BMP1 and HIF1A expression by real-time PCR in astr... | DisGeNET | Detail |
| SSD treatment inhibited STAT3 activation [phosphorylation of STAT3 (p‑STAT3)], reduced the protein l... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Two low oxygen sensors, Egl nine homolog 1 (EGLN1) and hypoxia-inducible factor 1-α inhibitor (HIF-1... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Here we show that upregulation of SHARP1 suppressed tumor angiogenesis by decreasing hypoxia-inducib... | DisGeNET | Detail |
| Our results suggest that the C1772T polymorphism of the HIF-1a may be associated with endometrial ca... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Recently, we reported that polycomb chromobox 4 (Cbx4) governs the transcriptional activity of HIF-1... | DisGeNET | Detail |
| Under hypoxic conditions, the mRNA and protein levels of ADM, as well as those of the cancer‑promoti... | DisGeNET | Detail |
| Upregulation of BNIP3 mediated by ERK/HIF-1α pathway induces autophagy and contributes to anoikis re... | DisGeNET | Detail |
| We also summarized the latest findings concerning the role of HIF-1 in the development of HCC, which... | DisGeNET | Detail |
| Taken together, we show that HDAC activity regulates HIF-1α translation, with HDACis such as SAHA re... | DisGeNET | Detail |
| Further investigations with a larger sample size may be required to validate the genetic effects of ... | DisGeNET | Detail |
| Saikosaponin‑d suppresses the expression of cyclooxygenase‑2 through the phospho‑signal transducer a... | DisGeNET | Detail |
| The mechanistic study revealed that ANXA3-mediated maintenance of HCC CSCs/CICs activity was likely ... | DisGeNET | Detail |
| HIF-1α plays a role in the chemotactic migration of hepatocarcinoma cells through the modulation of ... | DisGeNET | Detail |
| Furthermore, miR-338-3p sensitized HCC cells to sorafenib in vitro and in a HCC subcutaneous nude mi... | DisGeNET | Detail |
| This study suggests that γ-H2AX is associated with angiogenesis of HCC and γ-H2AX or a combination o... | DisGeNET | Detail |
| Our findings that reduced Beclin-1 and high HIF-1α expression are associated with the development an... | DisGeNET | Detail |
| Of the ten miRNAs predicted by the 3'-UTR of HIF-1α mRNA, PPIX treatment increased miR-199a-5p, lead... | DisGeNET | Detail |
| Levels of OPN protein expression were significantly correlated with HIF-1α protein levels in HCC tum... | DisGeNET | Detail |
| Our recent investigations showed that polycomb chromobox 4 (Cbx4) promotes angiogenesis and metastas... | DisGeNET | Detail |
| Thus, NF-κB both positively and negatively fine-tuned HIF-1 in hypoxic hepatocarcinoma cells. | DisGeNET | Detail |
| Since chronic hepatitis B (CHB), liver cirrhosis (LC), and HCC are progressive stages of chronic HBV... | DisGeNET | Detail |
| The role of hypoxia-inducible factor 1α in allergic rhinitis. | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Furthermore, using a gain and loss of function approach, we showed that increased hypoxia-inducible ... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Treatment of TNBC cell lines with dutasteride was associated with a dose-dependent decrease in cell ... | DisGeNET | Detail |
| Elevated Endothelial Hypoxia-Inducible Factor-1α Contributes to Glomerular Injury and Promotes Hyper... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Furthermore, using a gain and loss of function approach, we showed that increased hypoxia-inducible ... | DisGeNET | Detail |
| We used immunohistochemical staining of formalin-fixed paraffin-embedded BCC (n = 45) and TE (n = 35... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| At baseline (before treatment) cyclo-oxygenase 2 (COX2) was significantly up-regulated, while chemok... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Erythropoietin-mediated expression of placenta growth factor is regulated via activation of hypoxia-... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| This study identifies polymorphisms in the HIF1A and VEGF genes as potential genetic markers that in... | DisGeNET | Detail |
| Long noncoding RNA HIF1A-AS1A reduces apoptosis of vascular smooth muscle cells: implications for th... | DisGeNET | Detail |
| This study identifies polymorphisms in the HIF1A and VEGF genes as potential genetic markers that in... | DisGeNET | Detail |
| Our findings identify HIF1α to antagonize APC activation and Th1 T cell polarization during atheroge... | DisGeNET | Detail |
| This is the first study to provide evidence of a functional link between HIF1α, STAT3 and Notch-1 si... | DisGeNET | Detail |
| HMGB1 induces angiogenesis in rheumatoid arthritis via HIF-1α activation. | DisGeNET | Detail |
| Overexpression of HIF-1α almost completely reversed the suppressive effects of andrographolide on th... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| The role of HIF-1alpha in allergic airways has been investigated mainly in bronchial asthma. | DisGeNET | Detail |
| This study identifies polymorphisms in the HIF1A and VEGF genes as potential genetic markers that in... | DisGeNET | Detail |
| Our findings identify HIF1α to antagonize APC activation and Th1 T cell polarization during atheroge... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| In bladder cancer specimens, expression levels of glycolysis-related genes [glucose transporter (GLU... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| HIF-1α polymorphism in the susceptibility of cervical spondylotic myelopathy and its outcome after a... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| We used human glioma tissues and derived brain tumor stem cells (BTSCs) to study the expression of H... | DisGeNET | Detail |
| Inhibition or upregulation of HIF-1α affects breast cancer cell expression of BCRP; AI responsivenes... | DisGeNET | Detail |
| Analysis of the relationship between ultrasound of breast cancer DOT-SDI and the expression of MVD, ... | DisGeNET | Detail |
| MicroRNA-18a inhibits hypoxia-inducible factor 1α activity and lung metastasis in basal breast cance... | DisGeNET | Detail |
| These results clearly indicated that HIF-1α + COXIV + c-MYC (+ HER2 for HER2+ subtype) may be useful... | DisGeNET | Detail |
| HIF-1α decoy oligodeoxynucleotides inhibit HIF-1α signaling and breast cancer proliferation. | DisGeNET | Detail |
| Hypoxia induced E-cadherin involving regulators of Hippo pathway due to HIF-1α stabilization/nuclear... | DisGeNET | Detail |
| Increased expression of HIF-1α or HIF target genes in breast cancer biopsies was associated with dec... | DisGeNET | Detail |
| Associations between C1772T polymorphism in hypoxia-inducible factor-1α gene and breast cancer: a me... | DisGeNET | Detail |
| This meta-analysis demonstrates that both the C1772T and G1790A polymorphisms in the HIF-1α gene lik... | DisGeNET | Detail |
| HIF-1α (1772C>T) polymorphism as marker for breast cancer development. | DisGeNET | Detail |
| No association of hypoxia inducible factor-1α gene polymorphisms with breast cancer in North-West In... | DisGeNET | Detail |
| Furthermore, we show that up-regulated ΔNp73 levels are associated with increased angiogenesis in hu... | DisGeNET | Detail |
| 4-Hydroxynonenal promotes growth and angiogenesis of breast cancer cells through HIF-1α stabilizatio... | DisGeNET | Detail |
| Human breast cancer database analysis revealed that increased expression (greater than the median) o... | DisGeNET | Detail |
| Basal and therapy-driven hypoxia-inducible factor-1α confers resistance to endocrine therapy in estr... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| The anti-proliferative effect of L-carnosine correlates with a decreased expression of hypoxia induc... | DisGeNET | Detail |
| HIF-1α inhibition reverses multidrug resistance in colon cancer cells via downregulation of MDR1/P-g... | DisGeNET | Detail |
| Hypoxia-inducible factor-1α and semaphorin4D genes involved with tumor-associated macrophage-induced... | DisGeNET | Detail |
| The stable knockdown of HIF-1α or HIF-2α expression induced negative effects on the malignant phenot... | DisGeNET | Detail |
| Colon cancer cell response to the BH3-mimetic was unmodified by HIF-1 activation and OBX induced a d... | DisGeNET | Detail |
| Here we show that upregulation of SHARP1 suppressed tumor angiogenesis by decreasing hypoxia-inducib... | DisGeNET | Detail |
| Our results suggest that the C1772T polymorphism of the HIF-1a may be associated with endometrial ca... | DisGeNET | Detail |
| Gene and protein expression of glucose transporter 1 and glucose transporter 3 in human laryngeal ca... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Expression of VEGF, PlGF and HIF-1α protein was downregulated after NCRT in the rectal cancer tissue... | DisGeNET | Detail |
| Combining adjuvant HIF1α inhibitor chemotherapy with surgery might be an effective therapeutic strat... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Moreover, HPV-16 oncoproteins promoted HIF-1α protein stability possibly through enhancing the inter... | DisGeNET | Detail |
| Retinoblastoma binding protein 2 (RBP2) promotes HIF-1α-VEGF-induced angiogenesis of non-small cell ... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| The role of HIF1α in renal cell carcinoma tumorigenesis. | DisGeNET | Detail |
| MOTIF analysis of aberrantly hypermethylated regions revealed enrichment for binding sites of AP2a, ... | DisGeNET | Detail |
| In this study, we investigated the effect of SF1126 on hypoxic HIF-1α/HIF-2α stability as well as on... | DisGeNET | Detail |
Overlapped Transcript Coordinates
| Gene | Transcript ID | Exon Number | Chromosome | Start | Stop | Type | Amino Mutation | Transcript Position | Links |
|---|
Overlapped Transcript
| Gene | Transcript ID | Chromosome | Start | Stop | Links |
|---|
- Gene
- -
- dbSNP
- rs386519031 dbSNP
- Genome
- hg19
- Position
- chr14:62,162,231-62,214,977
- Variant Type
- snv
Genome browser