chr7:87132333:> Detail (hg19)

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Summary
Information
Links
Disease area statistics
MGeND
ClinVar
CIViC
DisGeNET
Annotation
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Information

Genome

Assembly	Position
hg19	chr7:87,132,333-87,342,639
hg38	chr7:87,503,017-87,713,323

HGVS

RefSeq

Type	Transcript	Protein

Summary

MGeND

Clinical significance
Variant entry
GWAS entry
Disease area statistics	Show details

Frequency

[No Data.]

Prediction

[No Data.]

ClinVar

Clinical Significance
Review star	[No Data.]
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Links

Disease area statistics

[No Data.]

MGeND

[No Data.]

ClinVar

[No Data.]

CIViC

[No Data.]

DisGeNET

Score	Disease name	Description	Source	Pubmed	Links
0.006	squamous cell carcinoma	NA	BeFree,GAD		Detail
<0.001	Carcinoma, Transitional Cell	NA	BeFree		Detail
0.010	Cardiovascular Diseases	ATP binding cassette transporter 1 (ABCB1) plays a critical role in the developm...	BeFree,GAD	25118983	Detail
<0.001	celiac disease	NA	BeFree		Detail
0.002	Neoplastic Cell Transformation	NA	GAD		Detail
<0.001	Malignant tumor of cervix	NA	BeFree		Detail
0.001	Primary biliary cirrhosis	NA	BeFree		Detail
0.003	Cholangitis, Sclerosing	NA	BeFree,GAD		Detail
<0.001	cholestasis	NA	BeFree		Detail
<0.001	chordoma	NA	BeFree		Detail
0.002	Congenital chromosomal disease	NA	BeFree		Detail
<0.001	colitis	NA	BeFree		Detail
0.054	ulcerative colitis	Association of ABCB1 polymorphisms and ulcerative colitis susceptibility.	BeFree,GAD,LHGDN	25755800	Detail
0.011	Colonic Neoplasms	NA	BeFree,LHGDN		Detail
0.011	colorectal carcinoma	Chemoresistance in multidrug-resistant (MDR) cells over expressing P-glycoprotei...	BeFree	24901713	Detail
0.011	colorectal carcinoma	Colorectal cancer susceptibility: apparent gender-related modulation by ABCB1 ge...	BeFree	25355168	Detail
0.133	Colorectal Neoplasms	NA	BeFree,CTD_human,GAD,LHGDN		Detail
<0.001	Coronary Arteriosclerosis	NA	BeFree		Detail
0.001	Coronary heart disease	NA	BeFree		Detail
0.026	Crohn Disease	Polymorphisms of MDR1 are associated with patient's GC response and a predisposi...	BeFree,GAD,LHGDN	25346426	Detail
0.009	cystic fibrosis	NA	BeFree,GAD,LHGDN		Detail
0.009	Mental Depression	NA	BeFree,GAD		Detail
0.002	depressive disorder	NA	BeFree		Detail
0.005	diabetes mellitus	NA	BeFree,GAD		Detail
0.080	Diabetes Mellitus, Experimental	NA	RGD		Detail
0.003	Diabetes Mellitus, Non-Insulin-Dependent	NA	BeFree,GAD		Detail
0.001	diarrhea	NA	BeFree		Detail
0.003	Down syndrome	NA	LHGDN		Detail
0.005	drug allergy	NA	GAD		Detail
0.002	Dyskinesia, Drug-Induced	NA	GAD		Detail
0.080	encephalitis	NA	RGD		Detail
0.003	Endometrial Neoplasms	NA	LHGDN		Detail
<0.001	Ependymoma	NA	BeFree		Detail
0.003	Epilepsy, Generalized	NA	BeFree,GAD		Detail
<0.001	erythema multiforme	NA	BeFree		Detail
0.120	Escherichia coli Infections	NA	CTD_human		Detail
0.121	Esophageal Neoplasms	NA	BeFree,CTD_human		Detail
<0.001	Extrapyramidal Disorders	NA	BeFree		Detail
<0.001	Fatigue	NA	BeFree		Detail
0.005	Femur Head Necrosis	NA	GAD		Detail
<0.001	fibrosarcoma	NA	BeFree		Detail
<0.001	pathologic fistula	NA	BeFree		Detail
0.005	gastritis	NA	BeFree,GAD		Detail
<0.001	Gastrointestinal Diseases	NA	BeFree		Detail
0.012	glioblastoma	Temozolomide induces the production of epidermal growth factor to regulate MDR1 ...	BeFree,GAD,LHGDN	25053824	Detail
0.012	glioblastoma	Taken together, we confirmed P-gp targeting of TMZ, a crucial regulator of TMZ r...	BeFree,GAD,LHGDN	26208431	Detail
0.010	Glioma	NA	BeFree,LHGDN		Detail
<0.001	glomerulonephritis	NA	BeFree		Detail
0.005	Graft-vs-Host Disease	NA	GAD		Detail
<0.001	chronic granulomatous disease	NA	BeFree		Detail
0.003	Graves Disease	NA	BeFree,GAD		Detail
<0.001	Hallucinations	NA	BeFree		Detail
0.007	Head and Neck Neoplasms	NA	GAD		Detail
0.121	congenital heart defects	NA	BeFree,CTD_human		Detail
0.080	Heart Diseases	NA	CTD_mouse		Detail
0.003	Heart failure	NA	BeFree,GAD		Detail
<0.001	congestive heart failure	NA	BeFree		Detail
<0.001	Heart Septal Defects	Maternal medication use, fetal 3435 C>T polymorphism of the ABCB1 gene, and risk...	BeFree	24740628	Detail
<0.001	Ventricular Septal Defects	In conclusion, fetal 3435 C>T polymorphism in the ABCB1 gene increases the risk ...	BeFree	24740628	Detail
<0.001	hepatitis	NA	BeFree		Detail
<0.001	hepatitis A	NA	BeFree		Detail
<0.001	hepatitis B	NA	BeFree		Detail
0.003	heroin dependence	NA	BeFree,GAD		Detail
<0.001	Herpes Simplex Infections	NA	BeFree		Detail
0.083	HIV Infections	NA	BeFree,GAD		Detail
<0.001	Hodgkin Disease	NA	BeFree		Detail
<0.001	HTLV-I Infections	NA	BeFree		Detail
0.005	Hyperbilirubinemia	NA	BeFree,GAD		Detail
0.012	Hypercholesterolemia	NA	BeFree,GAD		Detail
<0.001	Hypercholesterolemia, Familial	The mRNA expression and function of OATP1B1, ABCB1 and ABCG2 were assessed in pe...	BeFree	25084202	Detail
0.002	Hyperlipidemia	NA	GAD		Detail
0.011	Hypertensive disease	We hypothesized that the C(3435)T polymorphism in MDR-1 could be associated with...	BeFree,GAD	23161145	Detail
0.011	Hypertensive disease	Recent data indicate that enzymes and transporters involved in CNI pharmacokinet...	BeFree,GAD	25141899	Detail
0.005	hyperthyroidism	NA	GAD,LHGDN		Detail
0.120	Hypotension, Orthostatic	NA	CTD_human		Detail
0.002	hypothyroidism	NA	GAD		Detail
0.003	male infertility	NA	BeFree,GAD		Detail
0.005	Inflammation	NA	GAD,LHGDN		Detail
0.022	Inflammatory Bowel Diseases	Contribution of MDR1 gene polymorphisms on IBD predisposition and response to gl...	BeFree,GAD,LHGDN	25346426	Detail
0.022	Inflammatory Bowel Diseases	More than 50 polymorphisms of the MDR-1 gene have been described; a subset of th...	BeFree,GAD,LHGDN	25712147	Detail
<0.001	influenza	NA	BeFree		Detail
<0.001	Intestinal Diseases	Multi-drug resistance gene 1 (ABCB1) is closely related to bowel diseases.	BeFree	25755800	Detail
<0.001	irritable bowel syndrome	Contribution of MDR1 gene polymorphisms on IBD predisposition and response to gl...	BeFree	25346426	Detail
0.003	Creutzfeldt-Jakob disease	NA	LHGDN		Detail
<0.001	kernicterus	NA	BeFree		Detail
0.003	Kidney Diseases	NA	BeFree,GAD		Detail
<0.001	Kidney Failure, Acute	NA	BeFree		Detail
0.083	Kidney Failure, Chronic	NA	BeFree,GAD,RGD		Detail
0.123	Kidney Neoplasm	NA	BeFree,CTD_human,GAD		Detail
0.083	HIV Infections	Prevalence of MDR1 C3435T and CYP2B6 G516T polymorphisms among HIV-1 infected So...	BeFree	22297601	Detail
0.003	leiomyosarcoma	NA	BeFree,LHGDN		Detail
0.055	leukemia	Resistance to daunorubicin, imatinib, or nilotinib depends on expression levels ...	BeFree,GAD,LHGDN	24954033	Detail
0.003	kidney failure	The purpose of this study is to compare the genotype frequency of C3435T and G11...	BeFree	17376299	Detail
0.003	Acute Erythroblastic Leukemia	NA	BeFree,GAD		Detail
0.007	lymphoid leukemia	NA	BeFree,GAD		Detail
0.010	Acute lymphocytic leukemia	NA	BeFree		Detail
0.002	Acute Megakaryocytic Leukemias	NA	GAD		Detail
0.002	acute monocytic leukemia	NA	GAD		Detail
0.073	Leukemia, Myelocytic, Acute	Low MDR1 and BAALC expression identifies a new subgroup of intermediate cytogene...	BeFree,GAD,LHGDN	24855032	Detail
0.073	Leukemia, Myelocytic, Acute	Influence of ABCB1 polymorphisms upon the effectiveness of standard treatment fo...	BeFree,GAD,LHGDN	25558979	Detail
0.073	Leukemia, Myelocytic, Acute	A median fluorescence intensity ratio (MFIR) which measures the efflux of mitoxa...	BeFree,GAD,LHGDN	26002514	Detail
0.006	myeloid leukemia	NA	BeFree,GAD,LHGDN		Detail
0.003	Leukemia, Myeloid, Chronic-Phase	ABCB1 haplotypes but not individual SNPs predict for optimal response/failure in...	BeFree,GAD	25301112	Detail
0.002	acute myelomonocytic leukemia	NA	GAD		Detail
<0.001	prolymphocytic leukemia	NA	BeFree		Detail
0.009	acute promyelocytic leukemia	NA	BeFree,GAD,LHGDN		Detail
<0.001	Adult T-Cell Lymphoma/Leukemia	NA	BeFree		Detail
0.006	leukopenia	With respect to hematological and nonhematological toxicities, SNPs in drug tran...	BeFree,GAD	25340731	Detail
<0.001	lipoma	NA	BeFree		Detail
<0.001	liposarcoma	These results show that bortezomib exhibits preferential cytotoxicity toward SW8...	BeFree	25576094	Detail
<0.001	liver cirrhosis	NA	BeFree		Detail
0.200	Liver Cirrhosis, Experimental	NA	CTD_human,CTD_mouse		Detail
0.005	Liver diseases	NA	GAD		Detail
0.007	Liver neoplasms	NA	BeFree,LHGDN		Detail
0.003	Chronic Obstructive Airway Disease	NA	BeFree,GAD		Detail
0.012	Lung Neoplasms	NA	BeFree,LHGDN		Detail
0.003	Lupus Erythematosus, Systemic	NA	BeFree,GAD		Detail
0.005	lupus nephritis	NA	GAD		Detail
<0.001	lymphadenitis	NA	BeFree		Detail
0.011	lymphoma	Steroid derivatives were studied for their growth-inhibitory effect, cytotoxicit...	BeFree,LHGDN	25862866	Detail
<0.001	Lymphoma, Follicular	NA	BeFree		Detail
0.003	Lymphoma, Non-Hodgkin	NA	BeFree,LHGDN		Detail
0.003	Lymphoproliferative Disorders	NA	BeFree,GAD		Detail
0.003	malaria	NA	BeFree,GAD		Detail
<0.001	Malaria, Falciparum	NA	BeFree		Detail
<0.001	Primary malignant neoplasm of liver	NA	BeFree		Detail
0.015	Malignant neoplasm of stomach	Establishment and partial characterization of an epirubicin-resistant gastric ca...	BeFree,GAD	25169536	Detail
0.015	Malignant neoplasm of stomach	Association between ABCB1 immunohistochemical expression and overall survival in...	BeFree,GAD	25169549	Detail
0.015	Malignant neoplasm of stomach	Is the ABCB1 gene associated with the increased risk of gastric cancer developme...	BeFree,GAD	25236528	Detail
0.015	Malignant neoplasm of stomach	Manganese superoxide dismutase (MnSOD) has been shown to be associated with doxo...	BeFree,GAD	25499851	Detail
0.015	Malignant neoplasm of stomach	Acquisition of doxorubicin resistance facilitates migrating and invasive potenti...	BeFree,GAD	25686905	Detail
0.122	Marijuana Abuse	NA	CTD_human,GAD		Detail
0.001	medulloblastoma	NA	BeFree		Detail
<0.001	meningioma	NA	BeFree		Detail
<0.001	Mesothelioma	NA	BeFree		Detail
<0.001	Monosomy	NA	BeFree		Detail
0.032	multiple myeloma	NA	BeFree,GAD,LHGDN		Detail
0.002	multiple sclerosis	NA	GAD		Detail
0.003	myasthenia gravis	NA	BeFree,GAD		Detail
<0.001	Myelodysplasia	NA	BeFree		Detail
<0.001	Myeloproliferative disease	NA	BeFree		Detail
0.002	Nasopharyngeal Neoplasms	NA	GAD		Detail
0.120	Nausea	NA	CTD_human		Detail
<0.001	Nausea and vomiting	NA	BeFree		Detail
<0.001	neonatal abstinence syndrome	NA	BeFree		Detail
0.125	Neoplasm Metastasis	NA	BeFree,CTD_human		Detail
0.002	Pathologic Neovascularization	NA	GAD		Detail
0.002	nephroblastoma	NA	BeFree		Detail
0.003	nephrotic syndrome	NA	BeFree,GAD		Detail
0.120	nervous system disorder	NA	BeFree,CTD_human		Detail
0.129	neuroblastoma	The purpose of this project was to determine if the development of doxorubicin r...	BeFree,CTD_human,LHGDN	25128389	Detail
0.130	neutropenia	With respect to hematological and nonhematological toxicities, SNPs in drug tran...	BeFree,CTD_human,GAD	25340731	Detail
0.005	obesity	NA	BeFree,GAD		Detail
0.010	Bone necrosis	NA	GAD,LHGDN		Detail
0.008	osteosarcoma	Stathmin is key in reversion of doxorubicin resistance by arsenic trioxide in os...	BeFree	25310700	Detail
0.008	osteosarcoma	MicroRNA-301a modulates doxorubicin resistance in osteosarcoma cells by targetin...	BeFree	25727016	Detail
0.008	osteosarcoma	In conclusion, icariin possesses a reversal effect on multidrug resistance in MG...	BeFree	25747987	Detail
0.015	ovarian carcinoma	Paclitaxel sensitivity in relation to ABCB1 expression, efflux and single nucleo...	BeFree	24810093	Detail
0.015	ovarian carcinoma	This research provides some new information about doxorubicin resistance, indica...	BeFree	25285166	Detail
0.015	ovarian carcinoma	MDR1 siRNA loaded hyaluronic acid-based CD44 targeted nanoparticle systems circu...	BeFree	25687880	Detail
0.015	ovarian carcinoma	Inhibition of mdr1 by G-quadruplex oligonucleotides and reversal of paclitaxel r...	BeFree	25801244	Detail
0.015	ovarian carcinoma	The MDR1 gene is a direct target of the Wnt/β-catenin signaling pathway, which p...	BeFree	26053275	Detail
0.121	Pain, Postoperative	NA	BeFree,CTD_human		Detail
0.003	Pancreatic Neoplasm	NA	BeFree,GAD		Detail
0.150	Parkinson disease	NA	BeFree,CTD_human,GAD,LHGDN		Detail
0.009	Peptic Ulcer	ABCB1 expression in peptic ulcer patients and its connection with H. pylori Infe...	BeFree,GAD	25117101	Detail
0.121	Peripheral neuropathy	Seventeen polymorphisms in regulatory and coding regions of genes controlling VC...	BeFree,CTD_human	25084203	Detail
0.003	Pituitary Neoplasms	NA	LHGDN		Detail
0.001	Adenomatous Polyposis Coli	NA	BeFree		Detail
0.002	Postoperative Complications	NA	GAD		Detail
0.001	Preleukemia	NA	BeFree		Detail
0.003	Prostatic Neoplasms	NA	BeFree,LHGDN		Detail
<0.001	psoriasis	A pharmacogenetic study of ABCB1 polymorphisms and cyclosporine treatment respon...	BeFree	24889923	Detail
<0.001	Psychotic Disorders	NA	BeFree		Detail
<0.001	pyruvate carboxylase deficiency disease	NA	BeFree		Detail
0.003	kidney failure	NA	BeFree,GAD		Detail
0.080	Reperfusion Injury	NA	CTD_mouse		Detail
0.002	Respiratory Distress Syndrome, Newborn	NA	GAD		Detail
<0.001	Retroviridae Infections	NA	BeFree		Detail
0.001	rhabdomyosarcoma	NA	BeFree		Detail
<0.001	schizoaffective disorder	NA	BeFree		Detail
0.014	schizophrenia	Effects of genetic polymorphisms of CYP2D6, CYP3A5, and ABCB1 on the steady-stat...	BeFree,GAD	24682161	Detail
0.164	Seizures	NA	BeFree,CTD_mouse,GAD,RGD		Detail
<0.001	organic sexual dysfunction	NA	BeFree		Detail
0.002	Skin Neoplasms	NA	GAD		Detail
<0.001	Splenic Neoplasms	NA	BeFree		Detail
0.080	status epilepticus	NA	CTD_mouse		Detail
0.020	Stomach Neoplasms	NA	GAD,LHGDN		Detail
0.008	Cerebrovascular accident	NA	BeFree,GAD		Detail
<0.001	Substance Withdrawal Syndrome	NA	BeFree		Detail
<0.001	synovial sarcoma	NA	BeFree		Detail
0.002	thrombosis	NA	GAD		Detail
<0.001	Thyroid Diseases	NA	BeFree		Detail
0.002	Tobacco use disorder	NA	GAD		Detail
0.120	Chromosomal translocation	NA	CTD_human		Detail
0.002	tuberculosis	NA	GAD		Detail
0.002	Tuberculosis, Pulmonary	NA	GAD		Detail
0.003	tuberous sclerosis	NA	BeFree,LHGDN		Detail
0.120	Adverse reaction to drug	NA	CTD_human		Detail
0.002	Genitourinary Neoplasms	NA	GAD		Detail
0.002	Urologic Neoplasms	NA	GAD		Detail
0.002	vasculitis	NA	GAD		Detail
<0.001	viral hepatitis	NA	BeFree		Detail
0.121	Vomiting	NA	BeFree,CTD_human		Detail
0.002	Weight Gain	NA	GAD		Detail
0.041	Malignant neoplasm of lung	Heterozygote carriers of SNPs in CYP1A2 1545T>C, -164C>A and -740T>G; C...	BeFree	17259654	Detail
0.009	Carcinoma of lung	Heterozygote carriers of SNPs in CYP1A2 1545T>C, -164C>A and -740T>G; C...	BeFree	17259654	Detail
0.012	Helicobacter Infections	NA	GAD		Detail
<0.001	Ichthyosis, X-Linked	NA	BeFree		Detail
<0.001	B-Cell Lymphomas	NA	BeFree		Detail
0.122	diffuse large B-cell lymphoma	P2RY12 and P2RY1 had the highest frequency for gene gain in LUSC (26.95 and 26.6...	BeFree,CTD_human	25379720	Detail
<0.001	Immunoblastic Large-Cell Lymphoma	NA	BeFree		Detail
0.003	T-Cell Lymphoma	NA	BeFree,LHGDN		Detail
0.002	Lymphoma, T-Cell, Cutaneous	NA	GAD		Detail
0.002	peripheral T-cell lymphoma	NA	GAD		Detail
<0.001	Lymphoma, AIDS-Related	NA	BeFree		Detail
<0.001	severe combined immunodeficiency	NA	BeFree		Detail
0.002	Ovarian Failure, Premature	NA	GAD		Detail
0.003	cerebral amyloid angiopathy	NA	LHGDN		Detail
<0.001	essential hypertension	ABCB1 polymorphism and gender affect the pharmacokinetics of amlodipine in Chine...	BeFree	24522199	Detail
<0.001	Encephalopathies	NA	BeFree		Detail
<0.001	Polydipsia	NA	BeFree		Detail
0.008	acute leukemia	ABCB1 polymorphisms correlate with susceptibility to adult acute leukemia and re...	BeFree	25921280	Detail
<0.001	Chronic gastritis	NA	BeFree		Detail
<0.001	Depressive Symptoms	NA	BeFree		Detail
<0.001	Withdrawal Symptoms	NA	BeFree		Detail
<0.001	Pancreatitis, Chronic	NA	BeFree		Detail
<0.001	Epstein-Barr Virus Infections	NA	BeFree		Detail
<0.001	Squamous cell carcinoma of lung	P2RY12 and P2RY1 had the highest frequency for gene gain in LUSC (26.95 and 26.6...	BeFree	25379720	Detail
0.004	Small cell carcinoma of lung	NA	BeFree		Detail
<0.001	Complex partial seizures	NA	BeFree		Detail
<0.001	Chronic pain	NA	BeFree		Detail
<0.001	Sensory neuropathy	With respect to hematological and nonhematological toxicities, SNPs in drug tran...	BeFree	25340731	Detail
<0.001	Central nervous system depression (disorder)	NA	BeFree		Detail
<0.001	renal fibrosis	We investigated whether genetic polymorphisms affecting CYP3A5 and ABCB1 influen...	BeFree	25521359	Detail
0.002	Abnormal renal function	NA	GAD		Detail
<0.001	Adenocarcinoma of lung (disorder)	NA	BeFree		Detail
<0.001	esophageal carcinoma	NA	BeFree		Detail
0.002	gastroparesis	NA	GAD		Detail
<0.001	Drug withdrawal syndrome	NA	BeFree		Detail
<0.001	Malignant neoplasm of mouth	NA	BeFree		Detail
<0.001	Malignant neoplasm of gallbladder	NA	BeFree		Detail
<0.001	Malignant tumor of peritoneum	NA	BeFree		Detail
<0.001	uterine cancer	NA	BeFree		Detail
0.002	Malignant neoplasm of brain	NA	GAD		Detail
<0.001	Secondary malignant neoplasm of lung	NA	BeFree		Detail
0.030	Malignant neoplasm of ovary	ABCB1 G1199A polymorphism and ovarian cancer response to paclitaxel.	BeFree	17828752	Detail
0.015	ovarian carcinoma	ABCB1 G1199A polymorphism and ovarian cancer response to paclitaxel.	BeFree	17828752	Detail
<0.001	acute myocardial infarction	NA	BeFree		Detail
<0.001	Dermatitis, Phototoxic	NA	BeFree		Detail
0.002	Tumor Progression	NA	BeFree		Detail
<0.001	Liposarcoma, Pleomorphic	NA	BeFree		Detail
0.002	hepatoblastoma	NA	BeFree		Detail
<0.001	Neuroectodermal Tumor, Primitive	NA	BeFree		Detail
0.120	adrenocortical carcinoma	NA	BeFree,CTD_human		Detail
<0.001	Carcinoma, Lobular	NA	BeFree		Detail
<0.001	mucoepidermoid carcinoma	NA	BeFree		Detail
0.002	Adult Acute Myeloblastic Leukemia	NA	BeFree		Detail
0.001	pediatric acute myeloblastic leukemia	NA	BeFree		Detail
<0.001	uveal melanoma	NA	BeFree		Detail
<0.001	Lip and oral cavity carcinoma	NA	BeFree		Detail
0.122	Neurotoxicity Syndromes	NA	CTD_human,GAD		Detail
<0.001	gallbladder carcinoma	NA	BeFree		Detail
0.002	pancreatic carcinoma	NA	BeFree		Detail
<0.001	Alcohol or Other Drugs use	ABCB1 has been implicated in substance use, and in post hoc tests we found that ...	BeFree	25918995	Detail
<0.001	pediatric AIDS	NA	BeFree		Detail
0.008	Gastrointestinal Stromal Tumors	NA	GAD,LHGDN		Detail
0.002	Cancer of Nasopharynx	NA	GAD		Detail
<0.001	Anaplastic thyroid carcinoma	NA	BeFree		Detail
<0.001	Interstitial fibrosis	In multivariate analysis, grafts carrying ABCB1 3435T allele(s) developed signif...	BeFree	25521359	Detail
0.003	Dyslipidemias	NA	BeFree,GAD		Detail
0.041	Malignant neoplasm of lung	Inherited variation in the ATP-binding cassette transporter ABCB1 and survival a...	BeFree,GAD	25122423	Detail
0.041	Malignant neoplasm of lung	Pulmonary expression of CYP2A13 and ABCB1 is regulated by FOXA2, and their genet...	BeFree,GAD	25667220	Detail
<0.001	Drug usage	NA	BeFree		Detail
0.003	Neoplasm, Residual	NA	BeFree,LHGDN		Detail
0.123	Disease Progression	NA	CTD_human,LHGDN		Detail
<0.001	parathyroid adenoma	NA	BeFree		Detail
<0.001	Xeroderma pigmentosum, group B	NA	BeFree		Detail
<0.001	5,10-Methylenetetrahydrofolate reductase deficiency	NA	BeFree		Detail
<0.001	Myoclonic Epilepsy, Juvenile	NA	BeFree		Detail
0.002	Carcinoma breast stage IV	NA	BeFree		Detail
<0.001	Metastatic Renal Cell Cancer	Efflux pump ABCB1 single nucleotide polymorphisms and dose reductions in patient...	BeFree	24874929	Detail
<0.001	Disseminated neuroblastoma	NA	BeFree		Detail
<0.001	Recurrent Endometrial Cancer	NA	BeFree		Detail
0.003	Cancer of Head and Neck	NA	BeFree,GAD		Detail
<0.001	Liver and Intrahepatic Biliary Tract Carcinoma	NA	BeFree		Detail
<0.001	Philadelphia chromosome positive chronic myelogenous leukemia	NA	BeFree		Detail
<0.001	Squamous cell carcinoma of esophagus	NA	BeFree		Detail
<0.001	extraosseous Ewings sarcoma-primitive neuroepithelial tumor	NA	BeFree		Detail
0.006	Solid tumour	NA	BeFree,GAD		Detail
<0.001	stage, ovarian epithelial cancer	NA	BeFree		Detail
0.002	secondary acute myeloid leukemia	NA	BeFree		Detail
<0.001	Papillary serous cystadenocarcinoma	NA	BeFree		Detail
<0.001	malignant fibrous histiocytoma	NA	BeFree		Detail
<0.001	anaplastic oligodendroglioma	NA	BeFree		Detail
0.001	Adenocarcinoma of colon	Reversal of ABCB1-related Multidrug Resistance of Colonic Adenocarcinoma Cells b...	BeFree	26026084	Detail
<0.001	uterine corpus sarcoma	In the present study, we used knockdown and overexpression approaches in the fol...	BeFree	25596698	Detail
<0.001	Impaired cognition	Cognitive impairment in major depressive disorder predicts poor treatment outcom...	BeFree	25815420	Detail
<0.001	Manic	NA	BeFree		Detail
<0.001	Absence of pain sensation	The aim of this study was to investigate the significance of UGT2B7, OPRM1 and A...	BeFree	24703092	Detail
0.004	Malignant neoplasm of liver	NA	BeFree,GAD		Detail
<0.001	Sarcoma of liver	NA	BeFree		Detail
<0.001	malignant mesothelioma	NA	BeFree		Detail
<0.001	Malignant neoplasm of adrenal cortex	NA	BeFree		Detail
0.002	Malignant neoplasm of pancreas	NA	BeFree		Detail
<0.001	Nonorganic psychosis	NA	BeFree		Detail
<0.001	Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site	NA	BeFree		Detail
0.011	Malignant neoplasm of prostate	EGFR mediates docetaxel resistance in human castration-resistant prostate cancer...	BeFree,GAD	24888374	Detail
0.011	Malignant neoplasm of prostate	Steroid derivatives were studied for their growth-inhibitory effect, cytotoxicit...	BeFree,GAD	25862866	Detail
<0.001	Hematopoietic Neoplasms	NA	BeFree		Detail
0.124	Hematologic Neoplasms	NA	BeFree,CTD_human		Detail
<0.001	Pouchitis	NA	BeFree		Detail
0.003	Pancreatitis, Alcoholic	NA	BeFree,GAD		Detail
<0.001	Steroid-sensitive nephrotic syndrome	NA	BeFree		Detail
<0.001	Steroid-resistant nephrotic syndrome	NA	BeFree		Detail
<0.001	Chronic Kidney Insufficiency	Genetic variance in ABCB1 and CYP3A5 does not contribute toward the development ...	BeFree	25014506	Detail
<0.001	neuropathy	NA	BeFree		Detail
0.003	endometrial carcinoma	NA	BeFree,GAD		Detail
<0.001	Secondary malignant neoplasm of liver	NA	BeFree		Detail
<0.001	hiv-infection/aids	NA	BeFree		Detail
0.080	Sleep Apnea, Obstructive	NA	RGD		Detail
<0.001	Postoperative Nausea	NA	BeFree		Detail
0.003	Postoperative Nausea and Vomiting	NA	BeFree,GAD		Detail
<0.001	Acute myeloid leukemia, minimal differentiation	NA	BeFree		Detail
<0.001	Pervasive Development Disorder	NA	BeFree		Detail
<0.001	Opiate Addiction	NA	BeFree		Detail
0.003	Malignant neoplasm of esophagus	NA	BeFree,GAD		Detail
<0.001	Palmar-plantar erythrodysesthesia syndrome	NA	BeFree		Detail
<0.001	Thyroid carcinoma	NA	BeFree		Detail
<0.001	sexual dysfunction	NA	BeFree		Detail
<0.001	Malignant melanoma of eye	NA	BeFree		Detail
<0.001	primary sclerosing cholangitis	NA	BeFree		Detail
0.002	Menopause present (finding)	NA	GAD		Detail
0.002	Methotrexate poisoning	NA	GAD		Detail
0.006	Osteosarcoma of bone	Stathmin is key in reversion of doxorubicin resistance by arsenic trioxide in os...	BeFree	25310700	Detail
0.006	Osteosarcoma of bone	MicroRNA-301a modulates doxorubicin resistance in osteosarcoma cells by targetin...	BeFree	25727016	Detail
0.006	Osteosarcoma of bone	In conclusion, icariin possesses a reversal effect on multidrug resistance in MG...	BeFree	25747987	Detail
0.003	Carcinogenesis	In conclusion, this study found that ABCC2 and ABCG2 expression levels were alte...	BeFree	25793771	Detail
<0.001	monocytic leukemia	NA	BeFree		Detail
<0.001	Tumor Initiation	NA	BeFree		Detail
0.004	prostate carcinoma	EGFR mediates docetaxel resistance in human castration-resistant prostate cancer...	BeFree	24888374	Detail
0.004	prostate carcinoma	Steroid derivatives were studied for their growth-inhibitory effect, cytotoxicit...	BeFree	25862866	Detail
<0.001	cocaine dependence	ABCB1 has been implicated in substance use, and in post hoc tests we found that ...	BeFree	25918995	Detail
<0.001	Carcinoma testes	NA	BeFree		Detail
0.002	Hashimoto Disease	NA	GAD		Detail
0.006	Epithelial ovarian cancer	NA	BeFree		Detail
<0.001	Progressive Neoplastic Disease	NA	BeFree		Detail
0.002	Refractory cancer	NA	BeFree		Detail
0.009	Carcinoma of lung	Inherited variation in the ATP-binding cassette transporter ABCB1 and survival a...	BeFree	25122423	Detail
0.009	Carcinoma of lung	Pulmonary expression of CYP2A13 and ABCB1 is regulated by FOXA2, and their genet...	BeFree	25667220	Detail
<0.001	Ewings sarcoma-primitive neuroectodermal tumor (PNET)	NA	BeFree		Detail
<0.001	Malignant neoplasm of gastrointestinal tract	NA	BeFree		Detail
0.001	Secondary malignant neoplasm of lymph node	NA	BeFree		Detail
0.013	colon carcinoma	The expression of HIF-1α and MDR1/P-gp can be used as a predictive marker for ch...	BeFree	24901645	Detail
0.013	colon carcinoma	Sinomenine sensitizes multidrug-resistant colon cancer cells (Caco-2) to doxorub...	BeFree	24901713	Detail
0.011	stomach carcinoma	Establishment and partial characterization of an epirubicin-resistant gastric ca...	BeFree	25169536	Detail
0.011	stomach carcinoma	Association between ABCB1 immunohistochemical expression and overall survival in...	BeFree	25169549	Detail
0.011	stomach carcinoma	Is the ABCB1 gene associated with the increased risk of gastric cancer developme...	BeFree	25236528	Detail
0.011	stomach carcinoma	Manganese superoxide dismutase (MnSOD) has been shown to be associated with doxo...	BeFree	25499851	Detail
0.011	stomach carcinoma	Acquisition of doxorubicin resistance facilitates migrating and invasive potenti...	BeFree	25686905	Detail
0.002	Carcinoma of bladder	NA	BeFree		Detail
0.006	Central neuroblastoma	The purpose of this project was to determine if the development of doxorubicin r...	BeFree	25128389	Detail
0.002	Disorder of macula of retina	NA	GAD		Detail
0.006	Malignant neoplasm of kidney	NA	BeFree,GAD		Detail
<0.001	cardiac event	NA	BeFree		Detail
<0.001	central nervous system lymphoma	NA	BeFree		Detail
<0.001	Febrile Neutropenia	NA	BeFree		Detail
<0.001	early pregnancy	NA	BeFree		Detail
<0.001	Sarcoma, metastatic	NA	BeFree		Detail
<0.001	Brain Tumor, Primary	NA	BeFree		Detail
<0.001	adult acute lymphocytic leukemia	NA	BeFree		Detail
<0.001	Malignant Squamous Cell Neoplasm	NA	BeFree		Detail
0.001	malignant peripheral nerve sheath tumor	NA	BeFree		Detail
<0.001	Schizophrenia and related disorders	NA	BeFree		Detail
0.007	Helicobacter pylori infection	ABCB1 expression in peptic ulcer patients and its connection with H. pylori Infe...	BeFree,GAD	25117101	Detail
<0.001	Sickle Cell Dactylitis	NA	BeFree		Detail
<0.001	Invasive breast carcinoma	NA	BeFree		Detail
0.001	Myelosuppression	NA	BeFree		Detail
<0.001	Undifferentiated (Embryonal) Sarcoma	NA	BeFree		Detail
<0.001	breast adenocarcinoma	NA	BeFree		Detail
0.202	Drug-Induced Liver Injury	NA	CTD_human,CTD_mouse,GAD		Detail
<0.001	Pancolitis	NA	BeFree		Detail
0.002	Cardiotoxicity	NA	GAD		Detail
<0.001	Advanced cancer	NA	BeFree		Detail
0.006	ovarian neoplasm	NA	BeFree,LHGDN		Detail
<0.001	Ischemic stroke	ABCB1 hypomethylation is associated with decreased antiplatelet effects of clopi...	BeFree	25997249	Detail
<0.001	Ovarian adenocarcinoma	NA	BeFree		Detail
<0.001	Colorectal cancer metastatic	NA	BeFree		Detail
0.002	coronary restenosis	NA	GAD		Detail
<0.001	Hurthle Cell Tumor	NA	BeFree		Detail
0.200	Arthritis, Experimental	NA	CTD_human,RGD		Detail
0.004	Drug Resistant Epilepsy	HIF-1α may have a regulatory effect on MDR1 expression in refractory epilepsy, w...	BeFree	24590840	Detail
<0.001	Stage 4S neuroblastoma	NA	BeFree		Detail
0.030	Malignant neoplasm of ovary	Paclitaxel sensitivity in relation to ABCB1 expression, efflux and single nucleo...	BeFree,GAD	24810093	Detail
0.030	Malignant neoplasm of ovary	This research provides some new information about doxorubicin resistance, indica...	BeFree,GAD	25285166	Detail
0.030	Malignant neoplasm of ovary	MDR1 siRNA loaded hyaluronic acid-based CD44 targeted nanoparticle systems circu...	BeFree,GAD	25687880	Detail
0.030	Malignant neoplasm of ovary	Inhibition of mdr1 by G-quadruplex oligonucleotides and reversal of paclitaxel r...	BeFree,GAD	25801244	Detail
0.030	Malignant neoplasm of ovary	The MDR1 gene is a direct target of the Wnt/β-catenin signaling pathway, which p...	BeFree,GAD	26053275	Detail
<0.001	Skin toxicity	NA	BeFree		Detail
<0.001	High-Grade Prostatic Intraepithelial Neoplasia	NA	BeFree		Detail
0.121	Squamous cell carcinoma of the head and neck	NA	BeFree,CTD_human		Detail
0.007	sarcoma	NA	BeFree,LHGDN		Detail
<0.001	Chronic leukemia (category)	NA	BeFree		Detail
<0.001	X-Linked Combined Immunodeficiency Diseases	NA	BeFree		Detail
<0.001	Precursor B-cell lymphoblastic leukemia	NA	BeFree		Detail
<0.001	Chronic myeloproliferative disorder	NA	BeFree		Detail
0.002	Adenoma of large intestine	NA	GAD		Detail
<0.001	M5b Acute differentiated monocytic leukemia	NA	BeFree		Detail
0.001	Adenocarcinoma of large intestine	NA	BeFree		Detail
<0.001	Acute Myeloid Leukemia Arising from Previous Myelodysplastic Syndrome	NA	BeFree		Detail
<0.001	Epithelioma	More than 50 polymorphisms of the MDR-1 gene have been described; a subset of th...	BeFree	25712147	Detail
<0.001	Undifferentiated leukemia	NA	BeFree		Detail
0.002	renal carcinoma	NA	BeFree		Detail
0.162	Mammary Neoplasms	Taken together, our data indicate that breast tumors with alveolar structures po...	BeFree,CTD_human,LHGDN	24736530	Detail
0.162	Mammary Neoplasms	Survivin family proteins as novel molecular determinants of doxorubicin resistan...	BeFree,CTD_human,LHGDN	24886669	Detail
<0.001	Hippocampal sclerosis	NA	BeFree		Detail
<0.001	Primary Peritoneal Carcinoma	NA	BeFree		Detail
<0.001	Xenograft Model	NA	BeFree		Detail
0.045	colorectal cancer	Chemoresistance in multidrug-resistant (MDR) cells over expressing P-glycoprotei...	BeFree,GAD	24901713	Detail
0.045	colorectal cancer	Colorectal cancer susceptibility: apparent gender-related modulation by ABCB1 ge...	BeFree,GAD	25355168	Detail
<0.001	Phototoxicity	NA	BeFree		Detail
<0.001	Neoplasms, Intracranial	NA	BeFree		Detail
<0.001	Chronic Kidney Diseases	Genetic variance in ABCB1 and CYP3A5 does not contribute toward the development ...	BeFree	25014506	Detail
0.003	Renal Insufficiency	NA	BeFree,GAD		Detail
<0.001	Sphenoid Wing Meningioma	NA	BeFree		Detail
0.005	Delayed Graft Function	NA	GAD		Detail
<0.001	Glioblastoma multiforme	Temozolomide resistance occurred through a biphasic response; first, by a confor...	BeFree	25053824	Detail
<0.001	Cirrhosis	NA	BeFree		Detail
<0.001	androgen independent prostate cancer	NA	BeFree		Detail
0.001	Benign Prostatic Hyperplasia	NA	BeFree		Detail
<0.001	Nephrotic Syndrome, Minimal Change	MDR1 polymorphisms and idiopathic nephrotic syndrome in Slovak children: prelimi...	BeFree	25559283	Detail
<0.001	prostatic hypertrophy	NA	BeFree		Detail
<0.001	MULTICYSTIC RENAL DYSPLASIA, BILATERAL	NA	BeFree		Detail
<0.001	Glucocorticoid Receptor Deficiency	NA	BeFree		Detail
<0.001	Nonmedullary thyroid carcinoma, with or without cell oxyphilia	NA	BeFree		Detail
<0.001	uterine corpus cancer	NA	BeFree		Detail
0.006	coronary artery disease	NA	BeFree,GAD		Detail
<0.001	Cardiac Carcinoma	NA	BeFree		Detail
<0.001	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	NA	BeFree		Detail
0.160	Precursor Cell Lymphoblastic Leukemia Lymphoma	NA	BeFree,CTD_human,GAD,LHGDN		Detail
<0.001	Acute postoperative pain	Our preliminary results support the evidence that OPRM1/ABCB1 genotypes along wi...	BeFree	25809606	Detail
0.143	liver carcinoma	Association between the c.1564A>T genetic polymorphism of the MDR1 gene and hepa...	BeFree,CTD_human,LHGDN	25177961	Detail
0.143	liver carcinoma	Yet median expression of OCT1, OCT3, and MDR1 in HCC was significantly lower (1....	BeFree,CTD_human,LHGDN	25231932	Detail
0.143	liver carcinoma	Taken together, we clarify that ZHX2 represses NF-Y-mediated activation of MDR1 ...	BeFree,CTD_human,LHGDN	25473899	Detail
0.200	inflammatory bowel disease 13	NA	CTD_human,MGD		Detail
0.002	Weight Gain Adverse Event	NA	GAD		Detail
0.002	Chronic ulcerative colitis	NA	GAD		Detail
<0.001	Clear-cell metastatic renal cell carcinoma	NA	BeFree		Detail
<0.001	Early-Stage Breast Carcinoma	NA	BeFree		Detail
0.002	Hypotension Adverse Event	NA	GAD		Detail
<0.001	Ischemic Cerebrovascular Accident	ABCB1 hypomethylation is associated with decreased antiplatelet effects of clopi...	BeFree	25997249	Detail
0.004	myelodysplastic syndrome	NA	BeFree,LHGDN		Detail
<0.001	plasmablastic lymphoma	NA	BeFree		Detail
<0.001	Juvenile arthritis	NA	BeFree		Detail
<0.001	Progressive cGVHD	NA	BeFree		Detail
<0.001	Triple Negative Breast Neoplasms	Mesenchymal stem cell-induced doxorubicin resistance in triple negative breast c...	BeFree	25140317	Detail
<0.001	Breast cancer, lobular	NA	BeFree		Detail
0.002	Infection	NA	GAD		Detail
<0.001	juvenile rheumatoid arthritis	NA	BeFree		Detail
<0.001	Cytogenetically normal acute myeloid leukemia	NA	BeFree		Detail
<0.001	Congenital Abnormality	NA	BeFree		Detail
0.005	acquired immunodeficiency syndrome	NA	GAD		Detail
0.002	Addison Disease	NA	GAD		Detail
0.015	adenocarcinoma	NA	BeFree,GAD,LHGDN		Detail
<0.001	adenoma	NA	BeFree		Detail
<0.001	Adult Antisocial Behavior	Genome-wide association data suggest ABCB1 and immune-related gene sets may be i...	BeFree	25918995	Detail
<0.001	agranulocytosis	NA	BeFree		Detail
0.002	Alcoholic Intoxication, Chronic	NA	GAD		Detail
0.002	Amnesia	NA	GAD		Detail
<0.001	Fabry disease	NA	BeFree		Detail
<0.001	anorexia nervosa	NA	BeFree		Detail
<0.001	Anxiety Disorders	NA	BeFree		Detail
0.134	rheumatoid arthritis	Multidrug resistance protein-1 expression, function and polymorphisms in patient...	BeFree,CTD_human,GAD	24734954	Detail
0.134	rheumatoid arthritis	ABCB1 genetic variant and its associated tacrolimus pharmacokinetics affect rena...	BeFree,CTD_human,GAD	25817604	Detail
<0.001	Asthenia	NA	BeFree		Detail
0.003	asthma	NA	BeFree,GAD		Detail
0.002	autistic disorder	NA	GAD		Detail
0.001	Autoimmune Diseases	NA	BeFree		Detail
0.003	Balkan nephropathy	NA	BeFree,LHGDN		Detail
0.120	Mental disorders	NA	CTD_human		Detail
<0.001	bipolar disorder	NA	BeFree		Detail
0.004	Malignant neoplasm of urinary bladder	NA	BeFree,GAD		Detail
<0.001	Blast Phase	NA	BeFree		Detail
0.002	Blood Coagulation Disorders	NA	GAD		Detail
0.005	Brain Neoplasms	NA	BeFree,GAD		Detail
<0.001	cannabis dependence	NA	BeFree		Detail
<0.001	Carcinoid Tumor	NA	BeFree		Detail
0.008	Malignant tumor of colon	The expression of HIF-1α and MDR1/P-gp can be used as a predictive marker for ch...	BeFree	24901645	Detail
0.008	Malignant tumor of colon	Sinomenine sensitizes multidrug-resistant colon cancer cells (Caco-2) to doxorub...	BeFree	24901713	Detail
<0.001	Malignant neoplasm of endometrium	NA	BeFree		Detail
<0.001	Bronchioloalveolar Adenocarcinoma	NA	BeFree		Detail
0.127	Non-small cell lung carcinoma	NA	BeFree,CTD_human		Detail
0.011	renal cell carcinoma	NA	BeFree,GAD,LHGDN		Detail

Annotation

Annotations

Descrption	Source	Links
NA	DisGeNET	Detail
NA	DisGeNET	Detail
ATP binding cassette transporter 1 (ABCB1) plays a critical role in the development and progression ...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
Association of ABCB1 polymorphisms and ulcerative colitis susceptibility.	DisGeNET	Detail
NA	DisGeNET	Detail
Chemoresistance in multidrug-resistant (MDR) cells over expressing P-glycoprotein (P-gp) encoded by ...	DisGeNET	Detail
Colorectal cancer susceptibility: apparent gender-related modulation by ABCB1 gene polymorphisms.	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
Polymorphisms of MDR1 are associated with patient's GC response and a predisposition to CD in Chines...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
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NA	DisGeNET	Detail
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NA	DisGeNET	Detail
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NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
Temozolomide induces the production of epidermal growth factor to regulate MDR1 expression in gliobl...	DisGeNET	Detail
Taken together, we confirmed P-gp targeting of TMZ, a crucial regulator of TMZ resistance in GBM.	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
Maternal medication use, fetal 3435 C>T polymorphism of the ABCB1 gene, and risk of isolated septal ...	DisGeNET	Detail
In conclusion, fetal 3435 C>T polymorphism in the ABCB1 gene increases the risk for isolated septal ...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
The mRNA expression and function of OATP1B1, ABCB1 and ABCG2 were assessed in peripheral blood monon...	DisGeNET	Detail
NA	DisGeNET	Detail
We hypothesized that the C(3435)T polymorphism in MDR-1 could be associated with resistant hypertens...	DisGeNET	Detail
Recent data indicate that enzymes and transporters involved in CNI pharmacokinetics and pharmacodyna...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
Contribution of MDR1 gene polymorphisms on IBD predisposition and response to glucocorticoids in IBD...	DisGeNET	Detail
More than 50 polymorphisms of the MDR-1 gene have been described; a subset of these has been shown t...	DisGeNET	Detail
NA	DisGeNET	Detail
Multi-drug resistance gene 1 (ABCB1) is closely related to bowel diseases.	DisGeNET	Detail
Contribution of MDR1 gene polymorphisms on IBD predisposition and response to glucocorticoids in IBD...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
Prevalence of MDR1 C3435T and CYP2B6 G516T polymorphisms among HIV-1 infected South African patients...	DisGeNET	Detail
NA	DisGeNET	Detail
Resistance to daunorubicin, imatinib, or nilotinib depends on expression levels of ABCB1 and ABCG2 i...	DisGeNET	Detail
The purpose of this study is to compare the genotype frequency of C3435T and G1199A polymorphisms in...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
Low MDR1 and BAALC expression identifies a new subgroup of intermediate cytogenetic risk acute myelo...	DisGeNET	Detail
Influence of ABCB1 polymorphisms upon the effectiveness of standard treatment for acute myeloid leuk...	DisGeNET	Detail
A median fluorescence intensity ratio (MFIR) which measures the efflux of mitoxantrone (an ATP Bindi...	DisGeNET	Detail
NA	DisGeNET	Detail
ABCB1 haplotypes but not individual SNPs predict for optimal response/failure in Egyptian patients w...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
With respect to hematological and nonhematological toxicities, SNPs in drug transporters (ABCB1 and ...	DisGeNET	Detail
NA	DisGeNET	Detail
These results show that bortezomib exhibits preferential cytotoxicity toward SW872-S cells possibly ...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
Steroid derivatives were studied for their growth-inhibitory effect, cytotoxicity, reversal of multi...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
Establishment and partial characterization of an epirubicin-resistant gastric cancer cell line with ...	DisGeNET	Detail
Association between ABCB1 immunohistochemical expression and overall survival in gastric cancer pati...	DisGeNET	Detail
Is the ABCB1 gene associated with the increased risk of gastric cancer development?--preliminary res...	DisGeNET	Detail
Manganese superoxide dismutase (MnSOD) has been shown to be associated with doxorubicin resistance i...	DisGeNET	Detail
Acquisition of doxorubicin resistance facilitates migrating and invasive potentials of gastric cance...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
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NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
The purpose of this project was to determine if the development of doxorubicin resistance is associa...	DisGeNET	Detail
With respect to hematological and nonhematological toxicities, SNPs in drug transporters (ABCB1 and ...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
Stathmin is key in reversion of doxorubicin resistance by arsenic trioxide in osteosarcoma cells.	DisGeNET	Detail
MicroRNA-301a modulates doxorubicin resistance in osteosarcoma cells by targeting AMP-activated prot...	DisGeNET	Detail
In conclusion, icariin possesses a reversal effect on multidrug resistance in MG-63/DOX cells throug...	DisGeNET	Detail
Paclitaxel sensitivity in relation to ABCB1 expression, efflux and single nucleotide polymorphisms i...	DisGeNET	Detail
This research provides some new information about doxorubicin resistance, indicating that mitochondr...	DisGeNET	Detail
MDR1 siRNA loaded hyaluronic acid-based CD44 targeted nanoparticle systems circumvent paclitaxel res...	DisGeNET	Detail
Inhibition of mdr1 by G-quadruplex oligonucleotides and reversal of paclitaxel resistance in human o...	DisGeNET	Detail
The MDR1 gene is a direct target of the Wnt/β-catenin signaling pathway, which plays an important ro...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
ABCB1 expression in peptic ulcer patients and its connection with H. pylori Infection.	DisGeNET	Detail
Seventeen polymorphisms in regulatory and coding regions of genes controlling VCR targets (TUBB1, MA...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
A pharmacogenetic study of ABCB1 polymorphisms and cyclosporine treatment response in patients with ...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
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NA	DisGeNET	Detail
NA	DisGeNET	Detail
Effects of genetic polymorphisms of CYP2D6, CYP3A5, and ABCB1 on the steady-state plasma concentrati...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
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NA	DisGeNET	Detail
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NA	DisGeNET	Detail
NA	DisGeNET	Detail
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NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
Heterozygote carriers of SNPs in CYP1A2 1545T>C, -164C>A and -740T>G; CYP2A6 -47A>C; MDR...	DisGeNET	Detail
Heterozygote carriers of SNPs in CYP1A2 1545T>C, -164C>A and -740T>G; CYP2A6 -47A>C; MDR...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
P2RY12 and P2RY1 had the highest frequency for gene gain in LUSC (26.95 and 26.68%, respectively) wh...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
ABCB1 polymorphism and gender affect the pharmacokinetics of amlodipine in Chinese patients with ess...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
ABCB1 polymorphisms correlate with susceptibility to adult acute leukemia and response to high-dose ...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
P2RY12 and P2RY1 had the highest frequency for gene gain in LUSC (26.95 and 26.68%, respectively) wh...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
With respect to hematological and nonhematological toxicities, SNPs in drug transporters (ABCB1 and ...	DisGeNET	Detail
NA	DisGeNET	Detail
We investigated whether genetic polymorphisms affecting CYP3A5 and ABCB1 influence EMT and kidney fi...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
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NA	DisGeNET	Detail
NA	DisGeNET	Detail
ABCB1 G1199A polymorphism and ovarian cancer response to paclitaxel.	DisGeNET	Detail
ABCB1 G1199A polymorphism and ovarian cancer response to paclitaxel.	DisGeNET	Detail
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ABCB1 has been implicated in substance use, and in post hoc tests we found that variation in ABCB1 w...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
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In multivariate analysis, grafts carrying ABCB1 3435T allele(s) developed significantly less EMT and...	DisGeNET	Detail
NA	DisGeNET	Detail
Inherited variation in the ATP-binding cassette transporter ABCB1 and survival after chemotherapy fo...	DisGeNET	Detail
Pulmonary expression of CYP2A13 and ABCB1 is regulated by FOXA2, and their genetic interaction is as...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
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Efflux pump ABCB1 single nucleotide polymorphisms and dose reductions in patients with metastatic re...	DisGeNET	Detail
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Reversal of ABCB1-related Multidrug Resistance of Colonic Adenocarcinoma Cells by Phenothiazines.	DisGeNET	Detail
In the present study, we used knockdown and overexpression approaches in the following set of uterin...	DisGeNET	Detail
Cognitive impairment in major depressive disorder predicts poor treatment outcome, but ABCB1 genetic...	DisGeNET	Detail
NA	DisGeNET	Detail
The aim of this study was to investigate the significance of UGT2B7, OPRM1 and ABCB1 polymorphisms f...	DisGeNET	Detail
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EGFR mediates docetaxel resistance in human castration-resistant prostate cancer through the Akt-dep...	DisGeNET	Detail
Steroid derivatives were studied for their growth-inhibitory effect, cytotoxicity, reversal of multi...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
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NA	DisGeNET	Detail
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Genetic variance in ABCB1 and CYP3A5 does not contribute toward the development of chronic kidney di...	DisGeNET	Detail
NA	DisGeNET	Detail
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NA	DisGeNET	Detail
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Stathmin is key in reversion of doxorubicin resistance by arsenic trioxide in osteosarcoma cells.	DisGeNET	Detail
MicroRNA-301a modulates doxorubicin resistance in osteosarcoma cells by targeting AMP-activated prot...	DisGeNET	Detail
In conclusion, icariin possesses a reversal effect on multidrug resistance in MG-63/DOX cells throug...	DisGeNET	Detail
In conclusion, this study found that ABCC2 and ABCG2 expression levels were altered already in mild/...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
EGFR mediates docetaxel resistance in human castration-resistant prostate cancer through the Akt-dep...	DisGeNET	Detail
Steroid derivatives were studied for their growth-inhibitory effect, cytotoxicity, reversal of multi...	DisGeNET	Detail
ABCB1 has been implicated in substance use, and in post hoc tests we found that variation in ABCB1 w...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
Inherited variation in the ATP-binding cassette transporter ABCB1 and survival after chemotherapy fo...	DisGeNET	Detail
Pulmonary expression of CYP2A13 and ABCB1 is regulated by FOXA2, and their genetic interaction is as...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
The expression of HIF-1α and MDR1/P-gp can be used as a predictive marker for chemotherapy resistanc...	DisGeNET	Detail
Sinomenine sensitizes multidrug-resistant colon cancer cells (Caco-2) to doxorubicin by downregulati...	DisGeNET	Detail
Establishment and partial characterization of an epirubicin-resistant gastric cancer cell line with ...	DisGeNET	Detail
Association between ABCB1 immunohistochemical expression and overall survival in gastric cancer pati...	DisGeNET	Detail
Is the ABCB1 gene associated with the increased risk of gastric cancer development?--preliminary res...	DisGeNET	Detail
Manganese superoxide dismutase (MnSOD) has been shown to be associated with doxorubicin resistance i...	DisGeNET	Detail
Acquisition of doxorubicin resistance facilitates migrating and invasive potentials of gastric cance...	DisGeNET	Detail
NA	DisGeNET	Detail
The purpose of this project was to determine if the development of doxorubicin resistance is associa...	DisGeNET	Detail
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NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
ABCB1 expression in peptic ulcer patients and its connection with H. pylori Infection.	DisGeNET	Detail
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NA	DisGeNET	Detail
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NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
ABCB1 hypomethylation is associated with decreased antiplatelet effects of clopidogrel in Chinese is...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
HIF-1α may have a regulatory effect on MDR1 expression in refractory epilepsy, which is probably con...	DisGeNET	Detail
NA	DisGeNET	Detail
Paclitaxel sensitivity in relation to ABCB1 expression, efflux and single nucleotide polymorphisms i...	DisGeNET	Detail
This research provides some new information about doxorubicin resistance, indicating that mitochondr...	DisGeNET	Detail
MDR1 siRNA loaded hyaluronic acid-based CD44 targeted nanoparticle systems circumvent paclitaxel res...	DisGeNET	Detail
Inhibition of mdr1 by G-quadruplex oligonucleotides and reversal of paclitaxel resistance in human o...	DisGeNET	Detail
The MDR1 gene is a direct target of the Wnt/β-catenin signaling pathway, which plays an important ro...	DisGeNET	Detail
NA	DisGeNET	Detail
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NA	DisGeNET	Detail
NA	DisGeNET	Detail
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NA	DisGeNET	Detail
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NA	DisGeNET	Detail
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NA	DisGeNET	Detail
More than 50 polymorphisms of the MDR-1 gene have been described; a subset of these has been shown t...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
Taken together, our data indicate that breast tumors with alveolar structures possess resistance to ...	DisGeNET	Detail
Survivin family proteins as novel molecular determinants of doxorubicin resistance in organotypic hu...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
Chemoresistance in multidrug-resistant (MDR) cells over expressing P-glycoprotein (P-gp) encoded by ...	DisGeNET	Detail
Colorectal cancer susceptibility: apparent gender-related modulation by ABCB1 gene polymorphisms.	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
Genetic variance in ABCB1 and CYP3A5 does not contribute toward the development of chronic kidney di...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
Temozolomide resistance occurred through a biphasic response; first, by a conformational change in P...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
MDR1 polymorphisms and idiopathic nephrotic syndrome in Slovak children: preliminary results.	DisGeNET	Detail
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Our preliminary results support the evidence that OPRM1/ABCB1 genotypes along with age, weight and d...	DisGeNET	Detail
Association between the c.1564A>T genetic polymorphism of the MDR1 gene and hepatocellular carcinoma...	DisGeNET	Detail
Yet median expression of OCT1, OCT3, and MDR1 in HCC was significantly lower (1.4-, 2.7-, and 2-fold...	DisGeNET	Detail
Taken together, we clarify that ZHX2 represses NF-Y-mediated activation of MDR1 transcription and, i...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
ABCB1 hypomethylation is associated with decreased antiplatelet effects of clopidogrel in Chinese is...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
Mesenchymal stem cell-induced doxorubicin resistance in triple negative breast cancer.	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
Genome-wide association data suggest ABCB1 and immune-related gene sets may be involved in adult ant...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
Multidrug resistance protein-1 expression, function and polymorphisms in patients with rheumatoid ar...	DisGeNET	Detail
ABCB1 genetic variant and its associated tacrolimus pharmacokinetics affect renal function in patien...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
The expression of HIF-1α and MDR1/P-gp can be used as a predictive marker for chemotherapy resistanc...	DisGeNET	Detail
Sinomenine sensitizes multidrug-resistant colon cancer cells (Caco-2) to doxorubicin by downregulati...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail

Overlapped Transcript Coordinates

Gene	Transcript ID	Exon Number	Chromosome	Start	Stop	Type	Amino Mutation	Transcript Position	Links

Overlapped Transcript

Gene	Transcript ID	Chromosome	Start	Stop	Links

Gene: -
dbSNP: rs386545618 dbSNP
Genome: hg19
Position: chr7:87,132,333-87,342,639
Variant Type: snv

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