Annotation Detail
Information
- Associated Genes
- ABCB1
- Associated Variants
-
ABCB1 MUTATION
ABCB1 MUTATION - Associated Disease
- Glioblastoma multiforme
- Source Database
- DisGeNET
- Description
- Temozolomide resistance occurred through a biphasic response; first, by a conformational change in P-gp into the active form and, second, by releasing EGF, which caused autocrine stimulation of GBM cells to induce MDR1.
- Pubmed
- 25053824
- Section of the abstract supporting the evidence
- ALL_TEXT_3/3
- Number of the section of the abstract supporting the evidence
- 3
- Number of the sentence supporting the evidence
- 13
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.00081432561624091
Drugs