chr22:22113946:> Detail (hg19)

Information

Genome

Assembly Position
hg19 chr22:22,113,946-22,221,970
hg38 chr22:21,759,657-21,867,680 

HGVS

Type Transcript Protein
Summary

MGeND

Clinical significance
Variant entry
GWAS entry
Disease area statistics Show details

Frequency

[No Data.]

Prediction

[No Data.]

ClinVar

Clinical Significance
Review star [No Data.]
Show details
Links
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
[No Data.]
CIViC
[No Data.]
DisGeNET
Score Disease name Description Source Pubmed Links
0.137 squamous cell carcinoma Licochalcone-A induces intrinsic and extrinsic apoptosis via ERK1/2 and p38 phos... BeFree,CTD_human,LHGDN 25572524 Detail
0.137 squamous cell carcinoma Upregulation of B-cell translocation gene 2 by epigallocatechin-3-gallate via p3... BeFree,CTD_human,LHGDN 25721086 Detail
<0.001 Cardiomyopathy, Dilated NA BeFree Detail
0.120 brain ischemia NA CTD_human Detail
<0.001 Malignant tumor of cervix NA BeFree Detail
<0.001 Developmental Disabilities NA BeFree Detail
0.003 cholesteatoma NA BeFree,LHGDN Detail
0.001 chondrosarcoma NA BeFree Detail
<0.001 chordoma NA BeFree Detail
<0.001 choriocarcinoma CXCL12-CXCR7 signaling activates ERK and Akt pathways in human choriocarcinoma c... BeFree 24450273 Detail
0.001 colitis In TNBS-induced mouse colitis models, we observed the up-regulation of VPS4B was... BeFree 25533544 Detail
0.001 ulcerative colitis NA BeFree Detail
0.014 Colonic Neoplasms Pharmacological inhibition of p38 MAPK reduces tumor growth in patient-derived x... BeFree,LHGDN 25890501 Detail
0.008 colorectal carcinoma Silencing of CXCR7 gene represses growth and invasion and induces apoptosis in c... BeFree 25051350 Detail
0.008 colorectal carcinoma Taken together, the present study demonstrated that BK increases IL-6 production... BeFree 25109623 Detail
0.008 colorectal carcinoma In conclusion, PXN promotes Bcl-2 phosphorylation at Serine 87 via PXN-mediated ... BeFree 25826088 Detail
0.008 colorectal carcinoma Taken together, our study's findings indicate that the deregulation of β-catenin... BeFree 26267535 Detail
0.006 Colorectal Neoplasms TRAP1 is involved in BRAF regulation and downstream attenuation of ERK phosphory... BeFree,LHGDN 25239454 Detail
0.006 Colorectal Neoplasms Paxillin promotes colorectal tumor invasion and poor patient outcomes via ERK-me... BeFree,LHGDN 25826088 Detail
0.002 Crohn Disease Vacuolar protein sorting 4B regulates apoptosis of intestinal epithelial cells v... BeFree 25533544 Detail
0.003 adenoid cystic carcinoma NA BeFree,LHGDN Detail
<0.001 cystic fibrosis NA BeFree Detail
<0.001 Cytomegalovirus Infections NA BeFree Detail
0.003 Cessation of life NA LHGDN Detail
<0.001 depressive disorder NA BeFree Detail
<0.001 Dermatitis, Atopic NA BeFree Detail
<0.001 scleroderma NA BeFree Detail
0.001 diabetes mellitus NA BeFree Detail
0.080 Diabetes Mellitus, Experimental NA RGD Detail
<0.001 Diabetes Mellitus, Insulin-Dependent NA BeFree Detail
<0.001 Diabetes Mellitus, Non-Insulin-Dependent Our results indicated the considerably aberrant MAPK signaling in both insulin-s... BeFree 25758573 Detail
<0.001 Diabetic Angiopathies Our results indicate that an MKP-3 pathway might regulate ERK dephosphorylation ... BeFree 25014566 Detail
<0.001 Diabetic Nephropathy NA BeFree Detail
<0.001 DiGeorge syndrome NA BeFree Detail
<0.001 Dwarfism NA BeFree Detail
<0.001 echinococcosis NA BeFree Detail
<0.001 Eczema NA BeFree Detail
0.001 Experimental Autoimmune Encephalomyelitis NA BeFree Detail
0.004 endometriosis Lipoxin A4 suppresses the development of endometriosis in an ALX receptor-depend... BeFree,LHGDN 24923883 Detail
0.004 endometriosis Up-regulation of Bcl-2 by CD147 Through ERK Activation Results in Abnormal Cell ... BeFree,LHGDN 25996258 Detail
<0.001 Enteritis NA BeFree Detail
<0.001 epidermodysplasia verruciformis NA BeFree Detail
<0.001 epilepsy NA BeFree Detail
0.004 Esophageal Neoplasms NA BeFree,LHGDN Detail
<0.001 Fanconi anemia NA BeFree Detail
<0.001 fibrodysplasia ossificans progressiva NA BeFree Detail
0.003 Fibrosis NA LHGDN Detail
0.007 glioblastoma Taken together, p38 MAPK-MK2-HuR signalling may enhance the potential of intrins... BeFree,LHGDN 25088200 Detail
0.007 glioblastoma Application of a specific extracellular-related kinase 1/2 (ERK1/2) inhibitor, b... BeFree,LHGDN 25213694 Detail
0.009 Glioma Here we propose that the blinding of cell-cell contact sensing in gliomas is cau... BeFree,LHGDN 24858041 Detail
0.009 Glioma Furthermore, AND did not induce apoptosis or activate ERK and p53 in primary cul... BeFree,LHGDN 25162007 Detail
0.009 Glioma Taken together, our findings showed that HDAC3 contributed to VM in gliomas, pos... BeFree,LHGDN 25940092 Detail
0.120 Gliosis NA CTD_human Detail
<0.001 glomerulonephritis NA BeFree Detail
0.120 IgA glomerulonephritis NA CTD_human Detail
0.120 Head and Neck Neoplasms NA CTD_human Detail
0.083 Cardiomegaly NA LHGDN,RGD Detail
0.002 Heart failure NA BeFree Detail
0.002 congestive heart failure NA BeFree Detail
<0.001 Severe Dengue Syk and ERK may serve as new therapeutic targets for interfering with ADE-induce... BeFree 26032420 Detail
<0.001 hepatitis B NA BeFree Detail
0.003 hepatitis C NA BeFree,LHGDN Detail
0.008 HIV Infections The results of BNDF research show that neurotrophins regulate miRNAs in at least... BeFree,GAD 25544363 Detail
0.120 Hyperalgesia NA CTD_human Detail
0.005 hyperglycemia The sEng, sFlt-1, and interleukin-6 were up-regulated, whereas the VEGF and PlGF... BeFree,LHGDN 24793974 Detail
0.005 hyperglycemia These results indicate that high AR expression in the context of hyperglycemia a... BeFree,LHGDN 25541468 Detail
0.005 hyperglycemia Our results indicated the considerably aberrant MAPK signaling in both insulin-s... BeFree,LHGDN 25758573 Detail
<0.001 hyperinsulinism Irisin treatment significantly increased insulin-like growth factor 1 and decrea... BeFree 24614098 Detail
<0.001 Hypertensive disease NA BeFree Detail
<0.001 Immune System Diseases NA BeFree Detail
0.120 Female infertility NA CTD_human Detail
<0.001 Inflammatory Bowel Diseases NA BeFree Detail
0.002 influenza Roles of p38 MAPK in the regulation of the inflammatory response to swine influe... BeFree 25518721 Detail
0.002 ischemia NA BeFree Detail
<0.001 arthropathy NA BeFree Detail
0.003 actinic keratosis NA LHGDN Detail
0.121 Kidney Neoplasm NA BeFree,CTD_human Detail
<0.001 Fibroid Tumor NA BeFree Detail
0.007 leukemia Tetraspanin Family Member, CD82, Regulates Expression of EZH2 via Inactivation o... BeFree,LHGDN 25955299 Detail
0.003 chronic lymphocytic leukemia We also found that blocking ET(A)R via BQ-123 interferes with ERK phosphorylatio... BeFree 24901342 Detail
0.003 chronic lymphocytic leukemia BRAF inhibitor-associated ERK activation drives development of chronic lymphocyt... BeFree 25329694 Detail
0.001 hairy cell leukemia NA BeFree Detail
<0.001 Acute lymphocytic leukemia NA BeFree Detail
0.002 Leukemia, Myelocytic, Acute NA BeFree Detail
0.002 Myeloid Leukemia, Chronic NA BeFree Detail
<0.001 Leukemia, Myelomonocytic, Chronic NA BeFree Detail
<0.001 acute promyelocytic leukemia NA BeFree Detail
0.002 Liver neoplasms NA BeFree Detail
0.127 Lung Neoplasms At the molecular level, reduced activation of ERK MAPK, but not Akt, was observe... BeFree,CTD_human,LHGDN 24727895 Detail
0.001 Lupus Vulgaris NA BeFree Detail
0.001 Lupus Erythematosus, Discoid NA BeFree Detail
0.003 Lupus Erythematosus, Systemic NA BeFree Detail
<0.001 Lyme disease NA BeFree Detail
0.005 lymphoma We discovered that YC-1 induces apoptosis and inhibits tumour growth of breast c... BeFree,LHGDN 24697523 Detail
0.005 lymphoma Mechanistically, SHP2/ERK inhibition impedes c-Myc transcriptional activity, whi... BeFree,LHGDN 25193962 Detail
<0.001 Lymphoma, Follicular NA BeFree Detail
<0.001 Lymphoma, Non-Hodgkin NA BeFree Detail
0.001 malaria NA BeFree Detail
0.009 Malignant neoplasm of stomach Resistin-induced stromal cell-derived factor-1 expression through Toll-like rece... BeFree 24929539 Detail
0.009 Malignant neoplasm of stomach Deactivation of phosphorylation of ERK protein is one of the mechanisms of soraf... BeFree 25136776 Detail
0.009 Malignant neoplasm of stomach These data suggest that heparanase facilitates invasion and migration of human g... BeFree 25337202 Detail
0.009 Malignant neoplasm of stomach Combined treatment with p38 activator partially blocked the antimetastatic effec... BeFree 25502212 Detail
0.009 Malignant neoplasm of stomach These results indicated that CARLo-5 might serve as a pro-oncogenic lncRNA that ... BeFree 25674211 Detail
0.009 Malignant neoplasm of stomach WISP-2 suppressed GC cell metastasis through reversing EMT and suppressing the e... BeFree 26291058 Detail
0.004 medulloblastoma NA BeFree,LHGDN Detail
<0.001 Mesothelioma Mesothelioma tumors are locally invasive and our results clearly suggest that ac... BeFree 25557874 Detail
<0.001 mitral valve stenosis NA BeFree Detail
0.007 multiple myeloma In summary, our results suggest that quercetin suppresses the proliferation of M... BeFree,LHGDN 24397597 Detail
0.080 Multiple Organ Failure NA RGD Detail
0.123 multiple sclerosis NA BeFree,GAD,GWASCAT Detail
<0.001 spinal muscular atrophy NA BeFree Detail
<0.001 myasthenia gravis MAPK1 and RAF1 were responsible for most of this crosstalk (80%), likely reflect... BeFree 25705681 Detail
<0.001 Mycobacterium Infections NA BeFree Detail
0.080 myocardial infarction NA RGD Detail
0.080 Myocardial Reperfusion Injury NA RGD Detail
0.002 narcolepsy NA GAD Detail
0.120 Neoplasm Invasiveness NA CTD_human Detail
0.141 Neoplasm Metastasis Mechanistically, knockdown of FAP inactivated PTEN/PI3K/AKT and Ras-ERK and its ... BeFree,CTD_human,LHGDN 24722280 Detail
0.141 Neoplasm Metastasis Ubc13 was dispensable for transforming growth factor β (TGFβ)-induced SMAD activ... BeFree,CTD_human,LHGDN 25189770 Detail
0.141 Neoplasm Metastasis The oncogene ABL1 was a direct miR-3127-5p target, and miR-3127-5p regulated the... BeFree,CTD_human,LHGDN 25284075 Detail
0.141 Neoplasm Metastasis In conclusion, these findings demonstrate that EMT can be regulated by the CCL19... BeFree,CTD_human,LHGDN 25359618 Detail
0.141 Neoplasm Metastasis In conclusion, this study suggested that EMT process can be triggered by the BMP... BeFree,CTD_human,LHGDN 25448881 Detail
0.141 Neoplasm Metastasis Glycyrrhetinic acid potently suppresses breast cancer invasion and metastasis by... BeFree,CTD_human,LHGDN 25828376 Detail
0.141 Neoplasm Metastasis We also show that mice that have tumors with intrinsically high levels of active... BeFree,CTD_human,LHGDN 25853295 Detail
0.141 Neoplasm Metastasis WISP-2 suppressed GC cell metastasis through reversing EMT and suppressing the e... BeFree,CTD_human,LHGDN 26291058 Detail
0.120 Nerve Degeneration NA CTD_human Detail
0.005 neuroblastoma CFM-4 and -5 induced apoptosis in NB cells in part by activating pro-apoptotic s... BeFree 25033461 Detail
0.005 neuroblastoma Moreover, the data show that inhibition of p38 MAPK signalling potentiates the a... BeFree 25086905 Detail
0.005 neuroblastoma A cell-based assay was developed using natively expressed ORL-1 receptors on mou... BeFree 25677767 Detail
0.005 neuroblastoma Mechanistically treatment of NBs with small molecule inhibitors of EGFR (erlotin... BeFree 25756510 Detail
0.005 neuroblastoma Furthermore, the amount of phosphorylation of the kinase ERK and neurite outgrow... BeFree 25921289 Detail
<0.001 neurofibroma NA BeFree Detail
<0.001 neurofibromatosis 1 Moving beyond BRAFV600 targeting, a number of other molecular subsets--such as m... BeFree 25993155 Detail
0.003 Noonan syndrome NA BeFree Detail
0.002 obesity Taking together, we demonstrate here for the first time that Arg-II causes eNOS-... BeFree 25034973 Detail
0.002 obesity Current data exclude a major function of these syntrophins in ABCA1 activity and... BeFree 25625330 Detail
<0.001 Opioid withdrawal Our data suggest that H2S prevents the development of opioid withdrawal-induced ... BeFree 24824948 Detail
0.002 Degenerative polyarthritis Our results showed that increased basal COL10A1 expression in OA hMSCs was signi... BeFree 25091567 Detail
0.003 osteoporosis NA LHGDN Detail
0.005 osteosarcoma Taken together, data show CTGF elevating MMPs expression and subsequently promot... BeFree,LHGDN 25003330 Detail
0.005 osteosarcoma Taken together, our data suggest that miR-143 inhibits EGFR signaling through it... BeFree,LHGDN 25227664 Detail
0.006 ovarian carcinoma These regulatory effects of EC on ovarian cancer cell proliferation, migration a... BeFree 24892518 Detail
0.006 ovarian carcinoma MicroRNA-497 suppresses angiogenesis by targeting vascular endothelial growth fa... BeFree 25176450 Detail
0.006 ovarian carcinoma In conclusion, bortezomib may induce ERK phosphorylation to suppress cathepsin B... BeFree 25375375 Detail
0.006 ovarian carcinoma We conclude that the carboxy-terminal portion of the MUC16/CA125 protein is onco... BeFree 25965947 Detail
0.003 Paget Disease Extramammary NA LHGDN Detail
0.004 Pancreatic Neoplasm NA BeFree,LHGDN Detail
<0.001 Parkinson disease ERK-mediated phosphorylation of TFAM downregulates mitochondrial transcription: ... BeFree 24768991 Detail
<0.001 pemphigus vulgaris NA BeFree Detail
<0.001 periodontitis NA BeFree Detail
<0.001 Peripheral neuropathy NA BeFree Detail
<0.001 pheochromocytoma NA BeFree Detail
<0.001 pituitary adenoma NA BeFree Detail
<0.001 Pituitary Neoplasms NA BeFree Detail
<0.001 polycythemia vera NA BeFree Detail
0.014 Prostatic Neoplasms NA LHGDN Detail
<0.001 pseudomyxoma peritonei We tested RDEA119, a specific MEK1/2 (MAPK extracellular signal-regulated kinase... BeFree 25890193 Detail
0.004 psoriasis NA BeFree,LHGDN Detail
<0.001 Reoviridae Infections NA BeFree Detail
<0.001 Respiratory Syncytial Virus Infections NA BeFree Detail
<0.001 retinoblastoma MEK/ERK inhibitors are also in clinical trials and the importance of pRB inactiv... BeFree 25070358 Detail
0.002 rhabdomyosarcoma NA BeFree Detail
<0.001 Kaposi sarcoma Taken together, our data suggest that miR99a inhibits MMP7 and MMP13 through PI3... BeFree 25234715 Detail
<0.001 schizophrenia NA BeFree Detail
0.004 systemic scleroderma NA BeFree,LHGDN Detail
<0.001 scrub typhus NA BeFree Detail
<0.001 Seizures NA BeFree Detail
0.120 Sezary syndrome NA CTD_human Detail
0.080 Shock, Hemorrhagic NA RGD Detail
<0.001 Dermatologic disorders NA BeFree Detail
0.128 Stomach Neoplasms NA CTD_human,LHGDN Detail
<0.001 pheochromocytoma When expressed in rat pheochromocytoma cell line cells, the R151C, R160W and D29... BeFree 19755124 Detail
<0.001 substance dependence NA BeFree Detail
0.120 Substance Withdrawal Syndrome NA CTD_human Detail
<0.001 synovial sarcoma NA BeFree Detail
<0.001 thyroiditis NA BeFree Detail
0.001 tuberculosis NA BeFree Detail
<0.001 tuberous sclerosis NA BeFree Detail
<0.001 Unipolar Depression Eighty percent of these genes were functionally associated with a key stress res... BeFree 25734512 Detail
0.080 urethral obstruction NA RGD Detail
0.080 Urinary Incontinence NA RGD Detail
<0.001 Uterine Fibroids NA BeFree Detail
0.003 vaccinia NA LHGDN Detail
<0.001 varicocele Subjects with varicocele demonstrated a significant negative correlation between... BeFree 26209830 Detail
0.002 Virus Diseases Increased activation of mitogen-activated protein kinase p38 and its substrate h... BeFree 25427614 Detail
<0.001 Werner syndrome NA BeFree Detail
<0.001 Dental White Spot NA BeFree Detail
<0.001 yellow fever MEK/ERK activation plays a decisive role in yellow fever virus replication: impl... BeFree 25241249 Detail
<0.001 AIDS-Associated Nephropathy NA BeFree Detail
0.002 B-Cell Lymphomas Reversion of apoptotic resistance of TP53-mutated Burkitt lymphoma B-cells to sp... BeFree 24787013 Detail
0.002 B-Cell Lymphomas Lupalbigenin treatment significantly down-regulated survival proteins, including... BeFree 25964563 Detail
<0.001 Lymphoma, Large-Cell, Follicular NA BeFree Detail
<0.001 Lymphoma, T-Cell, Cutaneous NA BeFree Detail
<0.001 Pleural Effusion, Malignant NA BeFree Detail
<0.001 severe combined immunodeficiency NA BeFree Detail
<0.001 Neurofibrillary degeneration (morphologic abnormality) NA BeFree Detail
<0.001 Polycystic Kidney, Autosomal Dominant NA BeFree Detail
<0.001 acute leukemia NA BeFree Detail
<0.001 Depressive Symptoms NA BeFree Detail
<0.001 Epstein-Barr Virus Infections NA BeFree Detail
<0.001 Small cell carcinoma of lung NA BeFree Detail
<0.001 renal fibrosis NA BeFree Detail
<0.001 Cutaneous Melanoma NA BeFree Detail
<0.001 Dry skin NA BeFree Detail
0.002 Adenocarcinoma of lung (disorder) LATS2 mRNA level was found to be a significant independent predictor for surviva... BeFree 24976335 Detail
0.002 Adenocarcinoma of lung (disorder) Genetic alterations affecting the MAPK/ERK pathway are common in lung adenocarci... BeFree 25351745 Detail
0.002 Adenocarcinoma of lung (disorder) To elucidate how EGFR signaling is linked to metabolic activity, we investigated... BeFree 26023239 Detail
<0.001 esophageal carcinoma NA BeFree Detail
<0.001 Idiopathic pulmonary hypertension NA BeFree Detail
<0.001 Malignant neoplasm of mouth A putative novel protein, DEPDC1B, is overexpressed in oral cancer patients, and... BeFree 25091805 Detail
<0.001 Malignant neoplasm of gallbladder ARB blocked A2-induced GBC cell growth and activated ERK. BeFree 25663464 Detail
<0.001 Secondary malignant neoplasm of lung NA BeFree Detail
<0.001 Secondary malignant neoplasm of bone NA BeFree Detail
0.120 Streptococcal pneumonia NA CTD_human Detail
<0.001 allergic asthma NA BeFree Detail
<0.001 Intervertebral Disc Degeneration NA BeFree Detail
<0.001 Dermatitis, Allergic Contact NA BeFree Detail
<0.001 Sotos' syndrome NA BeFree Detail
0.003 Tumor Progression Furthermore, while p53R2, a p53-inducible peptide involved in the synthesis of d... BeFree 25086499 Detail
0.003 Tumor Progression Given the multiple context-dependent roles for αvβ3 in angiogenesis and tumor pr... BeFree 25249331 Detail
<0.001 Dysplastic Nevus NA BeFree Detail
<0.001 alveolar rhabdomyosarcoma NA BeFree Detail
<0.001 Rhabdomyosarcoma, Embryonal Production of reactive oxygen species (ROS) and activation of p38 MAPK have a ce... BeFree 26153023 Detail
<0.001 teratocarcinoma NA BeFree Detail
<0.001 adrenocortical carcinoma NA BeFree Detail
0.003 mucoepidermoid carcinoma NA BeFree,LHGDN Detail
0.004 cholangiocarcinoma WWOX suppresses cell growth and induces cell apoptosis via inhibition of P38 nuc... BeFree,LHGDN 25502636 Detail
<0.001 Cystadenocarcinoma, Serous NA BeFree Detail
<0.001 verrucous carcinoma NA BeFree Detail
<0.001 Nerve Sheath Tumors NA BeFree Detail
<0.001 Neuroendocrine Tumors NA BeFree Detail
<0.001 uveal melanoma NA BeFree Detail
<0.001 Lip and oral cavity carcinoma A putative novel protein, DEPDC1B, is overexpressed in oral cancer patients, and... BeFree 25091805 Detail
0.080 Shprintzen syndrome NA BeFree,MGD Detail
<0.001 Intestinal carcinoma Role of ERK-MAPK signaling pathway in pentagastrin-regulated growth of large int... BeFree 25253956 Detail
<0.001 Pulsus trigeminus NA BeFree Detail
<0.001 Memory impairment NA BeFree Detail
<0.001 Extrapyramidal sign NA BeFree Detail
<0.001 gallbladder carcinoma ARB blocked A2-induced GBC cell growth and activated ERK. BeFree 25663464 Detail
0.007 pancreatic carcinoma Further analysis showed that Cyr61 seemed to activate phosphatidylinositol 3-kin... BeFree 25104090 Detail
0.007 pancreatic carcinoma ERK pathway knockdown suppressed pancreatic cancer cell proliferation, invasion,... BeFree 25646808 Detail
0.007 pancreatic carcinoma This fission is driven by Erk2-mediated phosphorylation of Drp1 on Serine 616, a... BeFree 25658205 Detail
0.007 pancreatic carcinoma We propose that dual PI3K/mTOR inhibitors suppress a novel negative feedback loo... BeFree 25673820 Detail
0.007 pancreatic carcinoma ERK kinase phosphorylates and destabilizes the tumor suppressor FBW7 in pancreat... BeFree 25753158 Detail
0.007 pancreatic carcinoma Selective inhibition of the p38 alternative activation pathway in infiltrating T... BeFree 26479921 Detail
0.120 Cocaine-Related Disorders NA CTD_human Detail
<0.001 Gastrointestinal Stromal Tumors Analysis of western blotting data showed that total protein isoforms of Raf, MEK... BeFree 24970355 Detail
<0.001 Anaplastic thyroid carcinoma NA BeFree Detail
<0.001 Medullary carcinoma of thyroid Our investigation of the molecular mechanisms underlying these effects revealed ... BeFree 25435367 Detail
0.002 Papillary thyroid carcinoma Moreover, our results also showed that downregulation of NOB1 was able to signif... BeFree 25231838 Detail
0.002 Papillary thyroid carcinoma In addition, Ad/sh-NOB1 combined with DOX treatment significantly increased acti... BeFree 25592304 Detail
<0.001 bone destruction By using specific small hairpin RNAs for MAPK11, we demonstrated that p38β-media... BeFree 25066918 Detail
<0.001 Fibrosis, Liver NA BeFree Detail
<0.001 Iron deficiency NA BeFree Detail
0.007 Malignant neoplasm of lung The expression of tumour suppressor genes was reduced in tumours from current ve... BeFree 24727895 Detail
0.007 Malignant neoplasm of lung The results indicated that Sorcin may be used as a potential therapeutic target ... BeFree 25394367 Detail
0.007 Malignant neoplasm of lung Here, we reported that the AKT inhibitor perifosine and the MEK\ERK inhibitor ME... BeFree 25697899 Detail
<0.001 Bare Lymphocyte Syndrome NA BeFree Detail
<0.001 Neoplasm, Residual NA BeFree Detail
0.120 Sepsis NA BeFree,CTD_human Detail
<0.001 Psoriasis vulgaris NA BeFree Detail
<0.001 Muckle-Wells syndrome NA BeFree Detail
<0.001 Isovaleryl-CoA dehydrogenase deficiency Guanine nucleotide binding protein alpha13 (GNA13) and protein tyrosine phosphat... BeFree 25193986 Detail
<0.001 Myelokathexis NA BeFree Detail
<0.001 Virchow's node (disorder) Genome-wide analyses have identified four major signaling nodes that are most fr... BeFree 25070358 Detail
<0.001 Disease due to Parvoviridae NA BeFree Detail
<0.001 Rhinovirus infection NA BeFree Detail
<0.001 Malignant neoplasm of colon stage IV NA BeFree Detail
<0.001 Carcinoma breast stage IV NA BeFree Detail
<0.001 Metastatic Renal Cell Cancer C5aR is frequently expressed in metastatic renal cell carcinoma and plays a cruc... BeFree 25682807 Detail
0.001 Metastatic melanoma In this article, Paul B. Chapman, MD, Memorial Sloan Kettering Cancer Center, su... BeFree 24857055 Detail
0.001 Liver and Intrahepatic Biliary Tract Carcinoma Msi1 confers resistance to TRAIL by activating ERK in liver cancer cells. BeFree 25747387 Detail
0.001 Squamous cell carcinoma of esophagus Diallyl disulfide induces G2/M arrest and promotes apoptosis through the p53/p21... BeFree 25175641 Detail
0.001 Squamous cell carcinoma of esophagus Cyr61 promotes CD204 expression and the migration of macrophages via MEK/ERK pat... BeFree 25620088 Detail
<0.001 Adenocarcinoma Of Esophagus NA BeFree Detail
<0.001 cervical squamous cell carcinoma The data indicate that CIN genomes harbor unfixed mutations in addition to human... BeFree 25738363 Detail
<0.001 Solid tumour In conclusion, bortezomib may induce ERK phosphorylation to suppress cathepsin B... BeFree 25375375 Detail
<0.001 Oligodendroglioma, Childhood Oncogenic KIAA1549-BRAF fusion with activation of the MAPK/ERK pathway in pediat... BeFree 25794445 Detail
0.001 Adenocarcinoma of pancreas NA BeFree Detail
0.001 cervix carcinoma NA BeFree Detail
<0.001 Hyperplastic Polyp NA BeFree Detail
<0.001 anaplastic astrocytoma NA BeFree Detail
0.001 pilocytic astrocytoma NA BeFree Detail
<0.001 Adenocarcinoma of colon NA BeFree Detail
0.001 Malignant neoplasm of liver Msi1 confers resistance to TRAIL by activating ERK in liver cancer cells. BeFree 25747387 Detail
<0.001 malignant mesothelioma Overexpression of activin-A and -B in malignant mesothelioma - attenuated Smad3 ... BeFree 25557874 Detail
<0.001 Malignant melanoma of choroid NA BeFree Detail
0.006 Malignant neoplasm of pancreas ERK pathway knockdown suppressed pancreatic cancer cell proliferation, invasion,... BeFree 25646808 Detail
0.006 Malignant neoplasm of pancreas This fission is driven by Erk2-mediated phosphorylation of Drp1 on Serine 616, a... BeFree 25658205 Detail
0.006 Malignant neoplasm of pancreas We propose that dual PI3K/mTOR inhibitors suppress a novel negative feedback loo... BeFree 25673820 Detail
0.006 Malignant neoplasm of pancreas ERK kinase phosphorylates and destabilizes the tumor suppressor FBW7 in pancreat... BeFree 25753158 Detail
0.006 Malignant neoplasm of pancreas Selective inhibition of the p38 alternative activation pathway in infiltrating T... BeFree 26479921 Detail
<0.001 juvenile myelomonocytic leukemia NA BeFree Detail
0.001 Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site Combined CagA expression, p-SHP-2 expression, and p-ERK expression showed an inc... BeFree 25871616 Detail
0.001 Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site NA BeFree Detail
0.011 Malignant neoplasm of prostate MEK/ERK inhibitors are also in clinical trials and the importance of pRB inactiv... BeFree 25070358 Detail
0.011 Malignant neoplasm of prostate Chloride intracellular channel 1 regulates prostate cancer cell proliferation an... BeFree 25279971 Detail
0.011 Malignant neoplasm of prostate Finally, the results demonstrated that AQP3 upregulated matrix metalloproteinase... BeFree 25515250 Detail
0.011 Malignant neoplasm of prostate BP significantly inhibited phosphorylation of Akt and ERK-1/2, JNK and p38 in PC... BeFree 25655200 Detail
<0.001 Hematopoietic Neoplasms NA BeFree Detail
<0.001 cardiac sarcoidosis NA BeFree Detail
<0.001 Lymphatic Abnormalities NA BeFree Detail
<0.001 Chronic Infantile Neurological, Cutaneous, and Articular Syndrome NA BeFree Detail
0.001 lupus erythematosus NA BeFree Detail
<0.001 Skeletal dysplasia NA BeFree Detail
0.002 endometrial carcinoma Functional bioinformatics analysis identified as downstream targets multiple sig... BeFree 25686835 Detail
<0.001 Secondary malignant neoplasm of liver NA BeFree Detail
<0.001 Recurrent tumor NA BeFree Detail
<0.001 Peritoneal Fibrosis NA BeFree Detail
<0.001 Neurodegenerative Disorders This research highlights new bioactivities for gracilins, such as BACE1 and ERK ... BeFree 25724081 Detail
<0.001 Hepatitis C, Chronic NA BeFree Detail
<0.001 Malignant neoplasm of esophagus NA BeFree Detail
0.003 Thyroid carcinoma These results suggest that the AMPK and p38 MAPK signaling pathways may be usefu... BeFree 25045295 Detail
<0.001 Squamous cell carcinoma of skin CXCR7 expression correlates with tumor depth in cutaneous squamous cell carcinom... BeFree 25256412 Detail
0.001 Malignant glioma NA BeFree Detail
<0.001 Periodic syndrome NA BeFree Detail
0.002 Osteosarcoma of bone Taken together, data show CTGF elevating MMPs expression and subsequently promot... BeFree 25003330 Detail
0.002 Osteosarcoma of bone Taken together, our data suggest that miR-143 inhibits EGFR signaling through it... BeFree 25227664 Detail
<0.001 Costello syndrome (disorder) NA BeFree Detail
<0.001 Leukemogenesis NA BeFree Detail
<0.001 Tumor Initiation NA BeFree Detail
0.011 prostate carcinoma MEK/ERK inhibitors are also in clinical trials and the importance of pRB inactiv... BeFree 25070358 Detail
0.011 prostate carcinoma Chloride intracellular channel 1 regulates prostate cancer cell proliferation an... BeFree 25279971 Detail
0.011 prostate carcinoma Finally, the results demonstrated that AQP3 upregulated matrix metalloproteinase... BeFree 25515250 Detail
0.011 prostate carcinoma BP significantly inhibited phosphorylation of Akt and ERK-1/2, JNK and p38 in PC... BeFree 25655200 Detail
<0.001 Hashimoto Disease Furthermore, BAG3 knockdown increased the HT-induced phosphorylation of ERK afte... BeFree 25471019 Detail
0.002 Epithelial ovarian cancer In conclusion, CrkL protein is required for TGF-β signal pathways through AKT an... BeFree 25307974 Detail
0.002 Epithelial ovarian cancer CXCR7 signaling induced epithelial-mesenchymal transition by AKT and ERK pathway... BeFree 25359618 Detail
<0.001 Refractory cancer By far, the most common clinical resistance mechanism involves reactivation of t... BeFree 25320010 Detail
0.019 breast carcinoma By using specific small hairpin RNAs for MAPK11, we demonstrated that p38β-media... BeFree 25066918 Detail
0.019 breast carcinoma As the MAPK pathway is an important target for treating triple-negative breast c... BeFree 25073112 Detail
0.019 breast carcinoma Western blot analysis data indicate that MAPK/ERK and PI3K/Akt signaling in brea... BeFree 25127034 Detail
0.019 breast carcinoma Activating transcription factor-2 (ATF-2) has been implicated as a tumour suppre... BeFree 25141981 Detail
0.019 breast carcinoma Ubc13 was dispensable for transforming growth factor β (TGFβ)-induced SMAD activ... BeFree 25189770 Detail
0.019 breast carcinoma 6,7-di-O-acetylsinococuline (FK-3000) induces G2/M phase arrest in breast carcin... BeFree 25384584 Detail
0.019 breast carcinoma DUSP4 and MAPK8 interacted with calories to alter breast cancer risk; MAPK1 inte... BeFree 25629224 Detail
0.019 breast carcinoma Computational design, chemical synthesis, and biological evaluation of a novel E... BeFree 25742792 Detail
0.019 breast carcinoma These results suggest that GA impairs the p38 MAPK-AP1 signaling axis, leading t... BeFree 25828376 Detail
0.019 breast carcinoma Requirement of ERα and basal activities of EGFR and Src kinase in Cd-induced act... BeFree 26006730 Detail
0.007 Carcinoma of lung The expression of tumour suppressor genes was reduced in tumours from current ve... BeFree 24727895 Detail
0.007 Carcinoma of lung The results indicated that Sorcin may be used as a potential therapeutic target ... BeFree 25394367 Detail
0.007 Carcinoma of lung Here, we reported that the AKT inhibitor perifosine and the MEK\ERK inhibitor ME... BeFree 25697899 Detail
<0.001 Malignant neoplasm of gastrointestinal tract NA BeFree Detail
0.001 Secondary malignant neoplasm of lymph node Cytoplasmic/membranous expression of IL-23 (p19 and p40 subunits) and IL-23R, re... BeFree 25015728 Detail
0.006 colon carcinoma Activation of Rac1-ERK pathway and consequent upregulation of MMP-7 production m... BeFree 25136657 Detail
0.006 colon carcinoma Thymoquinone induces caspase-independent, autophagic cell death in CPT-11-resist... BeFree 25611974 Detail
0.006 colon carcinoma Combined ginger extract & Gelam honey modulate Ras/ERK and PI3K/AKT pathway gene... BeFree 25889965 Detail
0.006 colon carcinoma Our results show the importance of p38 MAPK in human colon tumor growth using a ... BeFree 25890501 Detail
0.009 stomach carcinoma Resistin-induced stromal cell-derived factor-1 expression through Toll-like rece... BeFree 24929539 Detail
0.009 stomach carcinoma These data suggest that EGF-induced activation of MMP7 and MMP13 in GC is throug... BeFree 25085584 Detail
0.009 stomach carcinoma Deactivation of phosphorylation of ERK protein is one of the mechanisms of soraf... BeFree 25136776 Detail
0.009 stomach carcinoma These data suggest that heparanase facilitates invasion and migration of human g... BeFree 25337202 Detail
0.009 stomach carcinoma Combined treatment with p38 activator partially blocked the antimetastatic effec... BeFree 25502212 Detail
0.009 stomach carcinoma These results indicated that CARLo-5 might serve as a pro-oncogenic lncRNA that ... BeFree 25674211 Detail
0.009 stomach carcinoma WISP-2 suppressed GC cell metastasis through reversing EMT and suppressing the e... BeFree 26291058 Detail
0.001 Carcinoma of bladder NA BeFree Detail
0.005 Central neuroblastoma CFM-4 and -5 induced apoptosis in NB cells in part by activating pro-apoptotic s... BeFree 25033461 Detail
0.005 Central neuroblastoma Moreover, the data show that inhibition of p38 MAPK signalling potentiates the a... BeFree 25086905 Detail
0.005 Central neuroblastoma A cell-based assay was developed using natively expressed ORL-1 receptors on mou... BeFree 25677767 Detail
0.005 Central neuroblastoma Mechanistically treatment of NBs with small molecule inhibitors of EGFR (erlotin... BeFree 25756510 Detail
0.005 Central neuroblastoma Furthermore, the amount of phosphorylation of the kinase ERK and neurite outgrow... BeFree 25921289 Detail
<0.001 Malignant neoplasm of kidney NA BeFree Detail
<0.001 malignant peripheral nerve sheath tumor NA BeFree Detail
<0.001 Kabuki make-up syndrome RAP1-mediated MEK/ERK pathway defects in Kabuki syndrome. BeFree 26280580 Detail
<0.001 malignant pleural mesothelioma DSF-Cu exposure stimulated apoptosis in MPM cells that involved activation of st... BeFree 24690739 Detail
0.002 Rhabdoid Tumor of the Kidney NA BeFree Detail
<0.001 Endothelial dysfunction NA BeFree Detail
<0.001 breast adenocarcinoma Obacunone exhibits anti-proliferative and anti-aromatase activity in vitro by in... BeFree 24927687 Detail
<0.001 Advanced cancer NA BeFree Detail
0.120 Cardiomyopathies NA BeFree,CTD_human Detail
<0.001 Erdheim-Chester disease NA BeFree Detail
0.129 ovarian neoplasm NA BeFree,CTD_human,LHGDN Detail
<0.001 Renal ischaemia NA BeFree Detail
<0.001 Ischemic stroke NA BeFree Detail
<0.001 Primary infection NOS NA BeFree Detail
<0.001 Colorectal cancer metastatic NA BeFree Detail
0.080 coronary restenosis NA RGD Detail
<0.001 Tauopathies NA BeFree Detail
<0.001 Arthritis, Collagen-Induced NA BeFree Detail
0.008 Malignant neoplasm of ovary These regulatory effects of EC on ovarian cancer cell proliferation, migration a... BeFree,GAD 24892518 Detail
0.008 Malignant neoplasm of ovary MicroRNA-497 suppresses angiogenesis by targeting vascular endothelial growth fa... BeFree,GAD 25176450 Detail
0.008 Malignant neoplasm of ovary In conclusion, bortezomib may induce ERK phosphorylation to suppress cathepsin B... BeFree,GAD 25375375 Detail
0.008 Malignant neoplasm of ovary We conclude that the carboxy-terminal portion of the MUC16/CA125 protein is onco... BeFree,GAD 25965947 Detail
0.002 Squamous cell carcinoma of the head and neck One potential therapeutic target for HNSCC is the RAS/RAF/MEK/ERK cascade, which... BeFree 26053277 Detail
<0.001 Anemia, Diamond-Blackfan NA BeFree Detail
<0.001 sarcoma NA BeFree Detail
<0.001 major depressive disorder Eighty percent of these genes were functionally associated with a key stress res... BeFree 25734512 Detail
<0.001 Cardio-facio-cutaneous syndrome These results suggest that our new Braf knockin mice recapitulate major features... BeFree 25035421 Detail
<0.001 Inflammatory disorder NA BeFree Detail
<0.001 Adenocarcinoma of large intestine NA BeFree Detail
<0.001 Classical Hodgkin's Lymphoma Moreover, several signal transduction pathways that are critical for the prolife... BeFree 25953622 Detail
<0.001 pulmonary sclerosing hemangioma The significance of p40 expression in sclerosing hemangioma of lung. BeFree 25130377 Detail
0.001 pancreatic ductal adenocarcinoma Prdx1 associates with the formation of membrane protrusions through modulation o... BeFree 25426613 Detail
<0.001 renal carcinoma NA BeFree Detail
0.024 Mammary Neoplasms The data suggest that ERK activation by Nodal signaling regulates c-myc and p27 ... BeFree,LHGDN 25073112 Detail
0.024 Mammary Neoplasms Antroquinonol from Antrodia Camphorata suppresses breast tumor migration/invasio... BeFree,LHGDN 25656647 Detail
<0.001 drug dependence NA BeFree Detail
<0.001 Angiogenic Switch Given the multiple context-dependent roles for αvβ3 in angiogenesis and tumor pr... BeFree 25249331 Detail
<0.001 Hepatocarcinogenesis NA BeFree Detail
<0.001 Tumor Angiogenesis NA BeFree Detail
<0.001 Xenograft Model Although it had relatively short half-life in serum, it was shown to be highly s... BeFree 25438047 Detail
0.008 colorectal cancer Silencing of CXCR7 gene represses growth and invasion and induces apoptosis in c... BeFree 25051350 Detail
0.008 colorectal cancer Taken together, the present study demonstrated that BK increases IL-6 production... BeFree 25109623 Detail
0.008 colorectal cancer In conclusion, PXN promotes Bcl-2 phosphorylation at Serine 87 via PXN-mediated ... BeFree 25826088 Detail
0.008 colorectal cancer Taken together, our study's findings indicate that the deregulation of β-catenin... BeFree 26267535 Detail
<0.001 androgen independent prostate cancer BP significantly inhibited phosphorylation of Akt and ERK-1/2, JNK and p38 in PC... BeFree 25655200 Detail
<0.001 Invasive Skin Melanoma NA BeFree Detail
0.120 CEROID LIPOFUSCINOSIS, NEURONAL, 6 NA CTD_human Detail
0.001 uterine corpus cancer Functional bioinformatics analysis identified as downstream targets multiple sig... BeFree 25686835 Detail
<0.001 coronary artery disease NA BeFree Detail
<0.001 Parvovirus B19 (disease) NA BeFree Detail
<0.001 Philadelphia chromosome-positive acute lymphoblastic leukemia We have also shown that metformin activates the ERK pathway in Ph+ALL cells, SUP... BeFree 26186064 Detail
0.003 Precursor Cell Lymphoblastic Leukemia Lymphoma NA BeFree,LHGDN Detail
0.010 liver carcinoma Long non-coding RNA URHC regulates cell proliferation and apoptosis via ZAK thro... BeFree 25013376 Detail
0.010 liver carcinoma The CXCR7-ERK-HNF4α cascade represents a new target for the differentiation ther... BeFree 25242412 Detail
0.010 liver carcinoma These results provide the first evidence that up-regulation of the UII/UT system... BeFree 25514221 Detail
0.010 liver carcinoma These results suggest that SIRT6 is required for TGF-β1/H2O2/HOCl to enhance the... BeFree 25683165 Detail
0.010 liver carcinoma Shp2 SUMOylation promotes ERK activation and hepatocellular carcinoma developmen... BeFree 25823821 Detail
<0.001 Destructive Arthritis NA BeFree Detail
<0.001 Triple-negative breast carcinoma Cross-talk between endoplasmic reticulum (ER) stress and the MEK/ERK pathway pot... BeFree 25527500 Detail
0.120 chromosome 22q11.2 deletion syndrome, distal NA ORPHANET Detail
<0.001 Autosomal dominant focal segmental glomerulosclerosis NA BeFree Detail
<0.001 Cavernous Hemangioma of Brain NA BeFree Detail
<0.001 Bare lymphocyte syndrome 2 NA BeFree Detail
<0.001 Nasopharyngeal carcinoma NA BeFree Detail
<0.001 Central Nervous System Sensitization NA BeFree Detail
<0.001 Pulmonary arterial hypertension NA BeFree Detail
<0.001 Ischemic Cerebrovascular Accident NA BeFree Detail
0.005 myelodysplastic syndrome NA LHGDN Detail
<0.001 FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder) NA BeFree Detail
<0.001 Parkinson Disease, Familial, Type 1 NA BeFree Detail
0.120 Juvenile arthritis NA CTD_human Detail
<0.001 Triple Negative Breast Neoplasms In aggressive, triple-negative, basal-like breast cancers, most tumors display i... BeFree 25073112 Detail
<0.001 Triple Negative Breast Neoplasms In the present study we discerned the molecular mechanisms of potential interact... BeFree 25527500 Detail
0.014 Infection NA LHGDN Detail
<0.001 Pulmonary hypertension, primary, 1, with hereditary hemorrhagic telangiectasia NA BeFree Detail
<0.001 achondroplasia NA BeFree Detail
0.012 adenocarcinoma Of the 44 additional adenocarcinomas, 13 (30%) showed p63 expression; p40 was ne... BeFree,LHGDN 25189640 Detail
0.012 adenocarcinoma The small interfering RNA (siRNA) was used to suppress CrkL in serous papillary ... BeFree,LHGDN 25307974 Detail
<0.001 adenoma NA BeFree Detail
<0.001 Alcoholic Intoxication, Chronic NA BeFree Detail
0.003 Alzheimer's disease This research highlights new bioactivities for gracilins, such as BACE1 and ERK ... BeFree,LHGDN 25724081 Detail
<0.001 Anaplasia NA BeFree Detail
0.005 Anoxia NA LHGDN Detail
<0.001 anthrax disease NA BeFree Detail
0.001 arteriosclerosis NA BeFree Detail
<0.001 arthritis NA BeFree Detail
0.006 rheumatoid arthritis (D) PGC-1β mediated NF-κB transcription in RA-FLS, but did not affect ERK and p3... BeFree 25367151 Detail
0.006 rheumatoid arthritis An involvement of SR-B1 mediated p38 MAPK signaling pathway in serum amyloid A-i... BeFree 25932604 Detail
0.006 rheumatoid arthritis Sprouty2 suppresses the inflammatory responses in rheumatoid arthritis fibroblas... BeFree 26265114 Detail
<0.001 asbestosis NA BeFree Detail
0.002 asthma NA BeFree Detail
0.001 Astrocytoma NA BeFree Detail
<0.001 Ataxia NA BeFree Detail
0.001 atherosclerosis NA BeFree Detail
0.081 autistic disorder The 16p11.2 deletion mouse model of autism exhibits altered cortical progenitor ... BeFree,MGD 25698753 Detail
<0.001 Autoimmune Diseases NA BeFree Detail
<0.001 Mental disorders NA BeFree Detail
<0.001 bipolar disorder NA BeFree Detail
0.001 Malignant neoplasm of urinary bladder NA BeFree Detail
0.003 Bowen's Disease NA LHGDN Detail
<0.001 Brain Neoplasms The naturally secreted and O-GlcNAcylated MIF binds to EGFR, thereby inhibiting ... BeFree 26280537 Detail
0.021 Malignant neoplasm of breast By using specific small hairpin RNAs for MAPK11, we demonstrated that p38β-media... BeFree,GAD 25066918 Detail
0.021 Malignant neoplasm of breast Western blot analysis data indicate that MAPK/ERK and PI3K/Akt signaling in brea... BeFree,GAD 25127034 Detail
0.021 Malignant neoplasm of breast Activating transcription factor-2 (ATF-2) has been implicated as a tumour suppre... BeFree,GAD 25141981 Detail
0.021 Malignant neoplasm of breast Ubc13 was dispensable for transforming growth factor β (TGFβ)-induced SMAD activ... BeFree,GAD 25189770 Detail
0.021 Malignant neoplasm of breast 6,7-di-O-acetylsinococuline (FK-3000) induces G2/M phase arrest in breast carcin... BeFree,GAD 25384584 Detail
0.021 Malignant neoplasm of breast DUSP4 and MAPK8 interacted with calories to alter breast cancer risk; MAPK1 inte... BeFree,GAD 25629224 Detail
0.021 Malignant neoplasm of breast Computational design, chemical synthesis, and biological evaluation of a novel E... BeFree,GAD 25742792 Detail
0.021 Malignant neoplasm of breast These results suggest that GA impairs the p38 MAPK-AP1 signaling axis, leading t... BeFree,GAD 25828376 Detail
0.021 Malignant neoplasm of breast Requirement of ERα and basal activities of EGFR and Src kinase in Cd-induced act... BeFree,GAD 26006730 Detail
<0.001 Burkitt lymphoma Reversion of apoptotic resistance of TP53-mutated Burkitt lymphoma B-cells to sp... BeFree 24787013 Detail
0.005 Malignant tumor of colon Activation of Rac1-ERK pathway and consequent upregulation of MMP-7 production m... BeFree 25136657 Detail
0.005 Malignant tumor of colon Thymoquinone induces caspase-independent, autophagic cell death in CPT-11-resist... BeFree 25611974 Detail
0.005 Malignant tumor of colon Combined ginger extract & Gelam honey modulate Ras/ERK and PI3K/AKT pathway gene... BeFree 25889965 Detail
0.005 Malignant tumor of colon Our results show the importance of p38 MAPK in human colon tumor growth using a ... BeFree 25890501 Detail
0.001 Malignant neoplasm of endometrium Functional bioinformatics analysis identified as downstream targets multiple sig... BeFree 25686835 Detail
<0.001 Rectal Carcinoma NA BeFree Detail
<0.001 Malignant neoplasm of skin NA BeFree Detail
0.002 Malignant neoplasm of thyroid These results suggest that the AMPK and p38 MAPK signaling pathways may be usefu... BeFree 25045295 Detail
<0.001 Bronchioloalveolar Adenocarcinoma NA BeFree Detail
<0.001 mucinous adenocarcinoma NA BeFree Detail
0.007 Non-small cell lung carcinoma Reduced miR-3127-5p expression promotes NSCLC proliferation/invasion and contrib... BeFree 25284075 Detail
0.007 Non-small cell lung carcinoma KRAS is frequently mutated in non-small cell lung cancers (NSCLC), resulting in ... BeFree 25342139 Detail
0.007 Non-small cell lung carcinoma Mig-6 overcomes gefitinib resistance by inhibiting EGFR/ERK pathway in non-small... BeFree 25400829 Detail
0.007 Non-small cell lung carcinoma FOXM1 regulated by ERK pathway mediates TGF-β1-induced EMT in NSCLC. BeFree 25700356 Detail
0.002 renal cell carcinoma Downregulation of tNASP inhibits proliferation through regulating cell cycle-rel... BeFree 25669170 Detail
Annotation

Annotations

DescrptionSourceLinks
Licochalcone-A induces intrinsic and extrinsic apoptosis via ERK1/2 and p38 phosphorylation-mediated... DisGeNET Detail
Upregulation of B-cell translocation gene 2 by epigallocatechin-3-gallate via p38 and ERK signaling ... DisGeNET Detail
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CXCL12-CXCR7 signaling activates ERK and Akt pathways in human choriocarcinoma cells. DisGeNET Detail
In TNBS-induced mouse colitis models, we observed the up-regulation of VPS4B was accompanied with th... DisGeNET Detail
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Pharmacological inhibition of p38 MAPK reduces tumor growth in patient-derived xenografts from colon... DisGeNET Detail
Silencing of CXCR7 gene represses growth and invasion and induces apoptosis in colorectal cancer thr... DisGeNET Detail
Taken together, the present study demonstrated that BK increases IL-6 production via B2R and the ERK... DisGeNET Detail
In conclusion, PXN promotes Bcl-2 phosphorylation at Serine 87 via PXN-mediated ERK activation, and ... DisGeNET Detail
Taken together, our study's findings indicate that the deregulation of β-catenin by ERK2-activated C... DisGeNET Detail
TRAP1 is involved in BRAF regulation and downstream attenuation of ERK phosphorylation and cell-cycl... DisGeNET Detail
Paxillin promotes colorectal tumor invasion and poor patient outcomes via ERK-mediated stabilization... DisGeNET Detail
Vacuolar protein sorting 4B regulates apoptosis of intestinal epithelial cells via p38 MAPK in Crohn... DisGeNET Detail
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Our results indicated the considerably aberrant MAPK signaling in both insulin-sensitive tissues of ... DisGeNET Detail
Our results indicate that an MKP-3 pathway might regulate ERK dephosphorylation through Nox4 during ... DisGeNET Detail
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Lipoxin A4 suppresses the development of endometriosis in an ALX receptor-dependent manner via the p... DisGeNET Detail
Up-regulation of Bcl-2 by CD147 Through ERK Activation Results in Abnormal Cell Survival in Human En... DisGeNET Detail
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Taken together, p38 MAPK-MK2-HuR signalling may enhance the potential of intrinsic (EGFRvIII) and ex... DisGeNET Detail
Application of a specific extracellular-related kinase 1/2 (ERK1/2) inhibitor, but not application o... DisGeNET Detail
Here we propose that the blinding of cell-cell contact sensing in gliomas is caused by an unusual me... DisGeNET Detail
Furthermore, AND did not induce apoptosis or activate ERK and p53 in primary cultured astrocyte cell... DisGeNET Detail
Taken together, our findings showed that HDAC3 contributed to VM in gliomas, possibly through the PI... DisGeNET Detail
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Syk and ERK may serve as new therapeutic targets for interfering with ADE-induced cytokine expressio... DisGeNET Detail
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The results of BNDF research show that neurotrophins regulate miRNAs in at least three ways: (1) ERK... DisGeNET Detail
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The sEng, sFlt-1, and interleukin-6 were up-regulated, whereas the VEGF and PlGF were down-regulated... DisGeNET Detail
These results indicate that high AR expression in the context of hyperglycemia and insulin deficienc... DisGeNET Detail
Our results indicated the considerably aberrant MAPK signaling in both insulin-sensitive tissues of ... DisGeNET Detail
Irisin treatment significantly increased insulin-like growth factor 1 and decreased myostatin gene e... DisGeNET Detail
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Roles of p38 MAPK in the regulation of the inflammatory response to swine influenza virus-induced ac... DisGeNET Detail
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Tetraspanin Family Member, CD82, Regulates Expression of EZH2 via Inactivation of p38 MAPK Signaling... DisGeNET Detail
We also found that blocking ET(A)R via BQ-123 interferes with ERK phosphorylation and CLL pro-surviv... DisGeNET Detail
BRAF inhibitor-associated ERK activation drives development of chronic lymphocytic leukemia. DisGeNET Detail
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At the molecular level, reduced activation of ERK MAPK, but not Akt, was observed in lung tumours of... DisGeNET Detail
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We discovered that YC-1 induces apoptosis and inhibits tumour growth of breast cancer cells via down... DisGeNET Detail
Mechanistically, SHP2/ERK inhibition impedes c-Myc transcriptional activity, which results in the re... DisGeNET Detail
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Resistin-induced stromal cell-derived factor-1 expression through Toll-like receptor 4 and activatio... DisGeNET Detail
Deactivation of phosphorylation of ERK protein is one of the mechanisms of sorafenib inhibiting gast... DisGeNET Detail
These data suggest that heparanase facilitates invasion and migration of human gastric cancer cells ... DisGeNET Detail
Combined treatment with p38 activator partially blocked the antimetastatic effects of baicalein, whi... DisGeNET Detail
These results indicated that CARLo-5 might serve as a pro-oncogenic lncRNA that promotes proliferati... DisGeNET Detail
WISP-2 suppressed GC cell metastasis through reversing EMT and suppressing the expression and activi... DisGeNET Detail
NA DisGeNET Detail
Mesothelioma tumors are locally invasive and our results clearly suggest that acivins have a tumor-p... DisGeNET Detail
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In summary, our results suggest that quercetin suppresses the proliferation of MM cells by down-regu... DisGeNET Detail
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MAPK1 and RAF1 were responsible for most of this crosstalk (80%), likely reflecting their central ro... DisGeNET Detail
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Mechanistically, knockdown of FAP inactivated PTEN/PI3K/AKT and Ras-ERK and its downstream signaling... DisGeNET Detail
Ubc13 was dispensable for transforming growth factor β (TGFβ)-induced SMAD activation but was requir... DisGeNET Detail
The oncogene ABL1 was a direct miR-3127-5p target, and miR-3127-5p regulated the activation of the A... DisGeNET Detail
In conclusion, these findings demonstrate that EMT can be regulated by the CCL19/CXCR7 axis in epith... DisGeNET Detail
In conclusion, this study suggested that EMT process can be triggered by the BMP2/BMPR axis in gastr... DisGeNET Detail
Glycyrrhetinic acid potently suppresses breast cancer invasion and metastasis by impairing the p38 M... DisGeNET Detail
We also show that mice that have tumors with intrinsically high levels of active AKT and ERK are mor... DisGeNET Detail
WISP-2 suppressed GC cell metastasis through reversing EMT and suppressing the expression and activi... DisGeNET Detail
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CFM-4 and -5 induced apoptosis in NB cells in part by activating pro-apoptotic stress-activated kina... DisGeNET Detail
Moreover, the data show that inhibition of p38 MAPK signalling potentiates the anti-neuroblastoma ac... DisGeNET Detail
A cell-based assay was developed using natively expressed ORL-1 receptors on mouse neuroblastoma cel... DisGeNET Detail
Mechanistically treatment of NBs with small molecule inhibitors of EGFR (erlotinib, cetuximab) and E... DisGeNET Detail
Furthermore, the amount of phosphorylation of the kinase ERK and neurite outgrowth increased upon Cb... DisGeNET Detail
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Moving beyond BRAFV600 targeting, a number of other molecular subsets--such as mutations in MEK, NRA... DisGeNET Detail
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Taking together, we demonstrate here for the first time that Arg-II causes eNOS-uncoupling through a... DisGeNET Detail
Current data exclude a major function of these syntrophins in ABCA1 activity and insulin release but... DisGeNET Detail
Our data suggest that H2S prevents the development of opioid withdrawal-induced hyperalgesia via sup... DisGeNET Detail
Our results showed that increased basal COL10A1 expression in OA hMSCs was significantly suppressed ... DisGeNET Detail
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Taken together, data show CTGF elevating MMPs expression and subsequently promoting tumor metastasis... DisGeNET Detail
Taken together, our data suggest that miR-143 inhibits EGFR signaling through its downstream ERK/MAP... DisGeNET Detail
These regulatory effects of EC on ovarian cancer cell proliferation, migration and invasion were ass... DisGeNET Detail
MicroRNA-497 suppresses angiogenesis by targeting vascular endothelial growth factor A through the P... DisGeNET Detail
In conclusion, bortezomib may induce ERK phosphorylation to suppress cathepsin B and inhibit the cat... DisGeNET Detail
We conclude that the carboxy-terminal portion of the MUC16/CA125 protein is oncogenic in NIH/3T3 cel... DisGeNET Detail
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ERK-mediated phosphorylation of TFAM downregulates mitochondrial transcription: implications for Par... DisGeNET Detail
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We tested RDEA119, a specific MEK1/2 (MAPK extracellular signal-regulated kinase [ERK] kinase) inhib... DisGeNET Detail
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MEK/ERK inhibitors are also in clinical trials and the importance of pRB inactivation in prostate ca... DisGeNET Detail
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Taken together, our data suggest that miR99a inhibits MMP7 and MMP13 through PI3k/Akt and ERK/MAPK s... DisGeNET Detail
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When expressed in rat pheochromocytoma cell line cells, the R151C, R160W and D294H MC1R variants ass... DisGeNET Detail
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Eighty percent of these genes were functionally associated with a key stress response signalling cas... DisGeNET Detail
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Subjects with varicocele demonstrated a significant negative correlation between head morphological ... DisGeNET Detail
Increased activation of mitogen-activated protein kinase p38 and its substrate heat-shock protein 27... DisGeNET Detail
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MEK/ERK activation plays a decisive role in yellow fever virus replication: implication as an antivi... DisGeNET Detail
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Reversion of apoptotic resistance of TP53-mutated Burkitt lymphoma B-cells to spindle poisons by exo... DisGeNET Detail
Lupalbigenin treatment significantly down-regulated survival proteins, including protein kinase B (p... DisGeNET Detail
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LATS2 mRNA level was found to be a significant independent predictor for survival status (disease-fr... DisGeNET Detail
Genetic alterations affecting the MAPK/ERK pathway are common in lung adenocarcinoma (LAD). DisGeNET Detail
To elucidate how EGFR signaling is linked to metabolic activity, we investigated the involvement of ... DisGeNET Detail
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A putative novel protein, DEPDC1B, is overexpressed in oral cancer patients, and enhanced anchorage-... DisGeNET Detail
ARB blocked A2-induced GBC cell growth and activated ERK. DisGeNET Detail
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Furthermore, while p53R2, a p53-inducible peptide involved in the synthesis of dNTPs normally works ... DisGeNET Detail
Given the multiple context-dependent roles for αvβ3 in angiogenesis and tumor progression, our novel... DisGeNET Detail
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Production of reactive oxygen species (ROS) and activation of p38 MAPK have a central role in trigge... DisGeNET Detail
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WWOX suppresses cell growth and induces cell apoptosis via inhibition of P38 nuclear translocation i... DisGeNET Detail
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A putative novel protein, DEPDC1B, is overexpressed in oral cancer patients, and enhanced anchorage-... DisGeNET Detail
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Role of ERK-MAPK signaling pathway in pentagastrin-regulated growth of large intestinal carcinoma. DisGeNET Detail
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ARB blocked A2-induced GBC cell growth and activated ERK. DisGeNET Detail
Further analysis showed that Cyr61 seemed to activate phosphatidylinositol 3-kinase (PI3K) but not e... DisGeNET Detail
ERK pathway knockdown suppressed pancreatic cancer cell proliferation, invasion, and angiogenesis. DisGeNET Detail
This fission is driven by Erk2-mediated phosphorylation of Drp1 on Serine 616, and both this phospho... DisGeNET Detail
We propose that dual PI3K/mTOR inhibitors suppress a novel negative feedback loop mediated by mTORC2... DisGeNET Detail
ERK kinase phosphorylates and destabilizes the tumor suppressor FBW7 in pancreatic cancer. DisGeNET Detail
Selective inhibition of the p38 alternative activation pathway in infiltrating T cells inhibits panc... DisGeNET Detail
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Analysis of western blotting data showed that total protein isoforms of Raf, MEK and ERK were simila... DisGeNET Detail
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Our investigation of the molecular mechanisms underlying these effects revealed that mortalin deplet... DisGeNET Detail
Moreover, our results also showed that downregulation of NOB1 was able to significantly activate con... DisGeNET Detail
In addition, Ad/sh-NOB1 combined with DOX treatment significantly increased activation of the p38 MA... DisGeNET Detail
By using specific small hairpin RNAs for MAPK11, we demonstrated that p38β-mediated p38 activity in ... DisGeNET Detail
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The expression of tumour suppressor genes was reduced in tumours from current versus never-smoking l... DisGeNET Detail
The results indicated that Sorcin may be used as a potential therapeutic target for MDR through inhi... DisGeNET Detail
Here, we reported that the AKT inhibitor perifosine and the MEK\ERK inhibitor MEK-162 synergisticall... DisGeNET Detail
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Guanine nucleotide binding protein alpha13 (GNA13) and protein tyrosine phosphatase type IVA (PTP4A)... DisGeNET Detail
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Genome-wide analyses have identified four major signaling nodes that are most frequently altered in ... DisGeNET Detail
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C5aR is frequently expressed in metastatic renal cell carcinoma and plays a crucial role in cell inv... DisGeNET Detail
In this article, Paul B. Chapman, MD, Memorial Sloan Kettering Cancer Center, summarizes the recent ... DisGeNET Detail
Msi1 confers resistance to TRAIL by activating ERK in liver cancer cells. DisGeNET Detail
Diallyl disulfide induces G2/M arrest and promotes apoptosis through the p53/p21 and MEK-ERK pathway... DisGeNET Detail
Cyr61 promotes CD204 expression and the migration of macrophages via MEK/ERK pathway in esophageal s... DisGeNET Detail
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The data indicate that CIN genomes harbor unfixed mutations in addition to human papilloma virus inf... DisGeNET Detail
In conclusion, bortezomib may induce ERK phosphorylation to suppress cathepsin B and inhibit the cat... DisGeNET Detail
Oncogenic KIAA1549-BRAF fusion with activation of the MAPK/ERK pathway in pediatric oligodendrogliom... DisGeNET Detail
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Msi1 confers resistance to TRAIL by activating ERK in liver cancer cells. DisGeNET Detail
Overexpression of activin-A and -B in malignant mesothelioma - attenuated Smad3 signaling responses ... DisGeNET Detail
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ERK pathway knockdown suppressed pancreatic cancer cell proliferation, invasion, and angiogenesis. DisGeNET Detail
This fission is driven by Erk2-mediated phosphorylation of Drp1 on Serine 616, and both this phospho... DisGeNET Detail
We propose that dual PI3K/mTOR inhibitors suppress a novel negative feedback loop mediated by mTORC2... DisGeNET Detail
ERK kinase phosphorylates and destabilizes the tumor suppressor FBW7 in pancreatic cancer. DisGeNET Detail
Selective inhibition of the p38 alternative activation pathway in infiltrating T cells inhibits panc... DisGeNET Detail
NA DisGeNET Detail
Combined CagA expression, p-SHP-2 expression, and p-ERK expression showed an increased positive pred... DisGeNET Detail
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MEK/ERK inhibitors are also in clinical trials and the importance of pRB inactivation in prostate ca... DisGeNET Detail
Chloride intracellular channel 1 regulates prostate cancer cell proliferation and migration through ... DisGeNET Detail
Finally, the results demonstrated that AQP3 upregulated matrix metalloproteinase‑3 (MMP‑3) expressio... DisGeNET Detail
BP significantly inhibited phosphorylation of Akt and ERK-1/2, JNK and p38 in PC-3 (immunoblotting),... DisGeNET Detail
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Functional bioinformatics analysis identified as downstream targets multiple signaling pathways pote... DisGeNET Detail
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This research highlights new bioactivities for gracilins, such as BACE1 and ERK inhibition, and prov... DisGeNET Detail
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These results suggest that the AMPK and p38 MAPK signaling pathways may be useful therapeutic target... DisGeNET Detail
CXCR7 expression correlates with tumor depth in cutaneous squamous cell carcinoma skin lesions and p... DisGeNET Detail
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Taken together, data show CTGF elevating MMPs expression and subsequently promoting tumor metastasis... DisGeNET Detail
Taken together, our data suggest that miR-143 inhibits EGFR signaling through its downstream ERK/MAP... DisGeNET Detail
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MEK/ERK inhibitors are also in clinical trials and the importance of pRB inactivation in prostate ca... DisGeNET Detail
Chloride intracellular channel 1 regulates prostate cancer cell proliferation and migration through ... DisGeNET Detail
Finally, the results demonstrated that AQP3 upregulated matrix metalloproteinase‑3 (MMP‑3) expressio... DisGeNET Detail
BP significantly inhibited phosphorylation of Akt and ERK-1/2, JNK and p38 in PC-3 (immunoblotting),... DisGeNET Detail
Furthermore, BAG3 knockdown increased the HT-induced phosphorylation of ERK after HT treatment, and ... DisGeNET Detail
In conclusion, CrkL protein is required for TGF-β signal pathways through AKT and ERK pathway, which... DisGeNET Detail
CXCR7 signaling induced epithelial-mesenchymal transition by AKT and ERK pathways in epithelial ovar... DisGeNET Detail
By far, the most common clinical resistance mechanism involves reactivation of the MAPK (RAF/MEK/ERK... DisGeNET Detail
By using specific small hairpin RNAs for MAPK11, we demonstrated that p38β-mediated p38 activity in ... DisGeNET Detail
As the MAPK pathway is an important target for treating triple-negative breast cancers, upstream Nod... DisGeNET Detail
Western blot analysis data indicate that MAPK/ERK and PI3K/Akt signaling in breast cancer cells with... DisGeNET Detail
Activating transcription factor-2 (ATF-2) has been implicated as a tumour suppressor in breast cance... DisGeNET Detail
Ubc13 was dispensable for transforming growth factor β (TGFβ)-induced SMAD activation but was requir... DisGeNET Detail
6,7-di-O-acetylsinococuline (FK-3000) induces G2/M phase arrest in breast carcinomas through p38 MAP... DisGeNET Detail
DUSP4 and MAPK8 interacted with calories to alter breast cancer risk; MAPK1 interacted with DOBS, di... DisGeNET Detail
Computational design, chemical synthesis, and biological evaluation of a novel ERK inhibitor (BL-EI0... DisGeNET Detail
These results suggest that GA impairs the p38 MAPK-AP1 signaling axis, leading to the repression of ... DisGeNET Detail
Requirement of ERα and basal activities of EGFR and Src kinase in Cd-induced activation of MAPK/ERK ... DisGeNET Detail
The expression of tumour suppressor genes was reduced in tumours from current versus never-smoking l... DisGeNET Detail
The results indicated that Sorcin may be used as a potential therapeutic target for MDR through inhi... DisGeNET Detail
Here, we reported that the AKT inhibitor perifosine and the MEK\ERK inhibitor MEK-162 synergisticall... DisGeNET Detail
NA DisGeNET Detail
Cytoplasmic/membranous expression of IL-23 (p19 and p40 subunits) and IL-23R, respectively were over... DisGeNET Detail
Activation of Rac1-ERK pathway and consequent upregulation of MMP-7 production may contribute to the... DisGeNET Detail
Thymoquinone induces caspase-independent, autophagic cell death in CPT-11-resistant lovo colon cance... DisGeNET Detail
Combined ginger extract & Gelam honey modulate Ras/ERK and PI3K/AKT pathway genes in colon cancer HT... DisGeNET Detail
Our results show the importance of p38 MAPK in human colon tumor growth using a preclinical model, a... DisGeNET Detail
Resistin-induced stromal cell-derived factor-1 expression through Toll-like receptor 4 and activatio... DisGeNET Detail
These data suggest that EGF-induced activation of MMP7 and MMP13 in GC is through phosphatidylinosit... DisGeNET Detail
Deactivation of phosphorylation of ERK protein is one of the mechanisms of sorafenib inhibiting gast... DisGeNET Detail
These data suggest that heparanase facilitates invasion and migration of human gastric cancer cells ... DisGeNET Detail
Combined treatment with p38 activator partially blocked the antimetastatic effects of baicalein, whi... DisGeNET Detail
These results indicated that CARLo-5 might serve as a pro-oncogenic lncRNA that promotes proliferati... DisGeNET Detail
WISP-2 suppressed GC cell metastasis through reversing EMT and suppressing the expression and activi... DisGeNET Detail
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CFM-4 and -5 induced apoptosis in NB cells in part by activating pro-apoptotic stress-activated kina... DisGeNET Detail
Moreover, the data show that inhibition of p38 MAPK signalling potentiates the anti-neuroblastoma ac... DisGeNET Detail
A cell-based assay was developed using natively expressed ORL-1 receptors on mouse neuroblastoma cel... DisGeNET Detail
Mechanistically treatment of NBs with small molecule inhibitors of EGFR (erlotinib, cetuximab) and E... DisGeNET Detail
Furthermore, the amount of phosphorylation of the kinase ERK and neurite outgrowth increased upon Cb... DisGeNET Detail
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RAP1-mediated MEK/ERK pathway defects in Kabuki syndrome. DisGeNET Detail
DSF-Cu exposure stimulated apoptosis in MPM cells that involved activation of stress-activated prote... DisGeNET Detail
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Obacunone exhibits anti-proliferative and anti-aromatase activity in vitro by inhibiting the p38 MAP... DisGeNET Detail
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These regulatory effects of EC on ovarian cancer cell proliferation, migration and invasion were ass... DisGeNET Detail
MicroRNA-497 suppresses angiogenesis by targeting vascular endothelial growth factor A through the P... DisGeNET Detail
In conclusion, bortezomib may induce ERK phosphorylation to suppress cathepsin B and inhibit the cat... DisGeNET Detail
We conclude that the carboxy-terminal portion of the MUC16/CA125 protein is oncogenic in NIH/3T3 cel... DisGeNET Detail
One potential therapeutic target for HNSCC is the RAS/RAF/MEK/ERK cascade, which is one of the major... DisGeNET Detail
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Eighty percent of these genes were functionally associated with a key stress response signalling cas... DisGeNET Detail
These results suggest that our new Braf knockin mice recapitulate major features of RASopathies and ... DisGeNET Detail
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Moreover, several signal transduction pathways that are critical for the proliferation and survival ... DisGeNET Detail
The significance of p40 expression in sclerosing hemangioma of lung. DisGeNET Detail
Prdx1 associates with the formation of membrane protrusions through modulation of the activity of p3... DisGeNET Detail
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The data suggest that ERK activation by Nodal signaling regulates c-myc and p27 proteins post-transl... DisGeNET Detail
Antroquinonol from Antrodia Camphorata suppresses breast tumor migration/invasion through inhibiting... DisGeNET Detail
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Given the multiple context-dependent roles for αvβ3 in angiogenesis and tumor progression, our novel... DisGeNET Detail
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Although it had relatively short half-life in serum, it was shown to be highly significant anti-tumo... DisGeNET Detail
Silencing of CXCR7 gene represses growth and invasion and induces apoptosis in colorectal cancer thr... DisGeNET Detail
Taken together, the present study demonstrated that BK increases IL-6 production via B2R and the ERK... DisGeNET Detail
In conclusion, PXN promotes Bcl-2 phosphorylation at Serine 87 via PXN-mediated ERK activation, and ... DisGeNET Detail
Taken together, our study's findings indicate that the deregulation of β-catenin by ERK2-activated C... DisGeNET Detail
BP significantly inhibited phosphorylation of Akt and ERK-1/2, JNK and p38 in PC-3 (immunoblotting),... DisGeNET Detail
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NA DisGeNET Detail
Functional bioinformatics analysis identified as downstream targets multiple signaling pathways pote... DisGeNET Detail
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We have also shown that metformin activates the ERK pathway in Ph+ALL cells, SUP-B15, a side effect ... DisGeNET Detail
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Long non-coding RNA URHC regulates cell proliferation and apoptosis via ZAK through the ERK/MAPK sig... DisGeNET Detail
The CXCR7-ERK-HNF4α cascade represents a new target for the differentiation therapy of HCC. DisGeNET Detail
These results provide the first evidence that up-regulation of the UII/UT system may enhance prolife... DisGeNET Detail
These results suggest that SIRT6 is required for TGF-β1/H2O2/HOCl to enhance the tumorigenicity of H... DisGeNET Detail
Shp2 SUMOylation promotes ERK activation and hepatocellular carcinoma development. DisGeNET Detail
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Cross-talk between endoplasmic reticulum (ER) stress and the MEK/ERK pathway potentiates apoptosis i... DisGeNET Detail
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In aggressive, triple-negative, basal-like breast cancers, most tumors display increased MEK and ERK... DisGeNET Detail
In the present study we discerned the molecular mechanisms of potential interaction between the endo... DisGeNET Detail
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Of the 44 additional adenocarcinomas, 13 (30%) showed p63 expression; p40 was negative in all cases. DisGeNET Detail
The small interfering RNA (siRNA) was used to suppress CrkL in serous papillary cystic adenocarcinom... DisGeNET Detail
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NA DisGeNET Detail
This research highlights new bioactivities for gracilins, such as BACE1 and ERK inhibition, and prov... DisGeNET Detail
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NA DisGeNET Detail
NA DisGeNET Detail
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(D) PGC-1β mediated NF-κB transcription in RA-FLS, but did not affect ERK and p38. DisGeNET Detail
An involvement of SR-B1 mediated p38 MAPK signaling pathway in serum amyloid A-induced angiogenesis ... DisGeNET Detail
Sprouty2 suppresses the inflammatory responses in rheumatoid arthritis fibroblast-like synoviocytes ... DisGeNET Detail
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The 16p11.2 deletion mouse model of autism exhibits altered cortical progenitor proliferation and br... DisGeNET Detail
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The naturally secreted and O-GlcNAcylated MIF binds to EGFR, thereby inhibiting the binding of EGF t... DisGeNET Detail
By using specific small hairpin RNAs for MAPK11, we demonstrated that p38β-mediated p38 activity in ... DisGeNET Detail
Western blot analysis data indicate that MAPK/ERK and PI3K/Akt signaling in breast cancer cells with... DisGeNET Detail
Activating transcription factor-2 (ATF-2) has been implicated as a tumour suppressor in breast cance... DisGeNET Detail
Ubc13 was dispensable for transforming growth factor β (TGFβ)-induced SMAD activation but was requir... DisGeNET Detail
6,7-di-O-acetylsinococuline (FK-3000) induces G2/M phase arrest in breast carcinomas through p38 MAP... DisGeNET Detail
DUSP4 and MAPK8 interacted with calories to alter breast cancer risk; MAPK1 interacted with DOBS, di... DisGeNET Detail
Computational design, chemical synthesis, and biological evaluation of a novel ERK inhibitor (BL-EI0... DisGeNET Detail
These results suggest that GA impairs the p38 MAPK-AP1 signaling axis, leading to the repression of ... DisGeNET Detail
Requirement of ERα and basal activities of EGFR and Src kinase in Cd-induced activation of MAPK/ERK ... DisGeNET Detail
Reversion of apoptotic resistance of TP53-mutated Burkitt lymphoma B-cells to spindle poisons by exo... DisGeNET Detail
Activation of Rac1-ERK pathway and consequent upregulation of MMP-7 production may contribute to the... DisGeNET Detail
Thymoquinone induces caspase-independent, autophagic cell death in CPT-11-resistant lovo colon cance... DisGeNET Detail
Combined ginger extract & Gelam honey modulate Ras/ERK and PI3K/AKT pathway genes in colon cancer HT... DisGeNET Detail
Our results show the importance of p38 MAPK in human colon tumor growth using a preclinical model, a... DisGeNET Detail
Functional bioinformatics analysis identified as downstream targets multiple signaling pathways pote... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
These results suggest that the AMPK and p38 MAPK signaling pathways may be useful therapeutic target... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
Reduced miR-3127-5p expression promotes NSCLC proliferation/invasion and contributes to dasatinib se... DisGeNET Detail
KRAS is frequently mutated in non-small cell lung cancers (NSCLC), resulting in activation of the ME... DisGeNET Detail
Mig-6 overcomes gefitinib resistance by inhibiting EGFR/ERK pathway in non-small cell lung cancer ce... DisGeNET Detail
FOXM1 regulated by ERK pathway mediates TGF-β1-induced EMT in NSCLC. DisGeNET Detail
Downregulation of tNASP inhibits proliferation through regulating cell cycle-related proteins and in... DisGeNET Detail

Overlapped Transcript Coordinates

Gene Transcript ID Exon Number Chromosome Start Stop Type Amino Mutation Transcript Position Links

Overlapped Transcript

Gene Transcript ID Chromosome Start Stop Links
Gene
-
dbSNP
rs386505388 dbSNP
Genome
hg19
Position
chr22:22,113,946-22,221,970
Variant Type
snv
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