Annotation Detail
Information
- Associated Genes
- MAPK1
- Associated Variants
-
MAPK1 MUTATION
MAPK1 MUTATION - Associated Disease
- Malignant neoplasm of pancreas
- Source Database
- DisGeNET
- Description
- This fission is driven by Erk2-mediated phosphorylation of Drp1 on Serine 616, and both this phosphorylation and mitochondrial fragmentation are increased in human pancreatic cancer.
- Pubmed
- 25658205
- Section of the abstract supporting the evidence
- ALL_TEXT_2/3
- Number of the section of the abstract supporting the evidence
- 2
- Number of the sentence supporting the evidence
- 4
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.00624316305784698
Drugs